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4.4k
A0A1F6QPG0
MTSLIKSIQDIKNVIAKSAKPLALIPTMGSLHAGHISLIQTAKSECKTIIVYIFVNPLQFGPNEDFSEYPKDLASDLKTCEENNVDFVFAPEINEIYPDIESVKRNLITPPCELADILCGKTRENHFSGVATVIKRFFDIIEPDFAYFGEKDLQQLYIIKWLVKEFNLPVTVQSCPIVREHTGLAYSSRNKYLSADEKNIAASLYKALKLARGNTRSGIFPLNKAILESLIFLSHFPEIKVEYFEAKDKTNLANVHNDTKHGFYYLIAAKIKKVRLIDNIEVP
Pathway: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. Function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Catalytic Activity: (R)-pantoate + ATP + beta-alanine = (R)-...
A0A2R8BWP1
MGAILLTIICILGVGLGIGLYVSVTIGFTALGVGLIFSDRPVWDALSYLPYNAVTTVTLLALPLFILMGELLLRSGITERMYDTVSKWLNWLPGGLLHTNIVASGLFACVSGSSPATAATIGGVAIPYMSKRGYDQRMMLGSIAGGGTLGILIPPSIVMIVYAVLAGESIGQLYIAGVVPGLILLGLCLGVILIAARVRPALAPKEASTSWAEKLAGLVWLLPILGLIVAVLGSIYAGVATPTEAAAFGVTGALIIAAMTGRLSLSMLRETLLATAATTSMIMLILVGAFLLQFVMAFLGLPVAMARAIAAWDLSTLQIV...
Function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system. Subcellular Location: Cell inner membrane Sequence Length: 434 Sequence Mass (Da): 45589 Location Topology: Multi-pass membrane protein
A0A174FS72
MRKRTRKHRGTAGKMVGGFLAFFCLILLTAGMFWAIQGYVSYQKAVKEKPLAQAVEEARSGAQWASLEQVPDLYKKAVLAVEDHRYYTHHGIDWISMARAVVHDIRVMKPEQGGSTITQQLVKNMYYDQNKTFARKAAEAWTALYVERQLSKEEILELYINTIYFGDGYYGLKEASLGYFGKEPQELTDSEAVLLAGIPNAPSAYAPSRHADLALQREKQVLAAMVKYGYLEQSETDSLLWDAAADPVLAR
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. EC: 2.4.1.129 Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [...
A0A498K3H7
MALSDQTFFHNCLIALYLIAPPTFISLRFLQAPYGKHRRPGWGPTMSPPLAWFLMESPTLWLTLLLFPSGRHSSNPKALLLITPFLFHYFHRTCLYPLRLHRDTASSKSSAGGFPVSVAAMAFGFNLLNAYLQGRWISEYKDYESDGWFWWRFMGGLAVFGYGMGVNIWSDSVLVGLKKEGGGYKVPKGGWFELVSCPNYYGEIVEWAGWAVMTWSWVGLGFFLYTCANLVPRARANHRWYLEKFGEDYPKGRKAVLPFLY
Pathway: Plant hormone biosynthesis; brassinosteroid biosynthesis. Function: Involved in a reduction step in the biosynthesis of the plant steroid, brassinolide. Catalytic Activity: a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH EC: 1.3.1.22 Subcellular Location: Membrane Sequence Length: 26...
A0A8H4SME8
MANAQKSFKLSTGAEIPAIGLGTWQDEAAQEAAVLVALQAGYRHIDTARCYGTETAVGKAIKQSGVPRSEIFVTSKLWNNKHYPDDVEQALQMTLDDLGLEYLDLFLMHWPVAFKRGDDPFPSDKDGNLITDDIDYVDTYKAMEGLVKSGKAKAIGIANFSRKEVERLLANATIKPAVHQMELHPWLQQEEFHKFHQAQGIHVTQYSPFGNQNEIYGSREKHGQLVNDKTLVEIGKKVWKNFQSSRPRYVLPYFSMVIKLILIAAWGIAHGRSVIPKSKSPERIMQNFDIAFELAPTDIQKIDSIHKKLRFNDSSKDFGY...
Function: Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-p...
A0A2T2QZ35
MLKQPNRLRRQKDFARVFKHGDTVHMPAFSVKYHANHHPSRTRVAVVISSKVAKRAVIRNRTRRRFYGQIQLFWPRIRPGMDVVILLRRQATDLRGAQLAEQLRSCFHKAGILH
Function: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of...
A0A934MUS7
MKTTSLKGKITVQYSLLFLACMSIVGLLVYQVVADIVQNIAINYIHETIKQTNEKIDQTLTEVENSSSTTISNWYIQTLLNRHEKYLPLRDRVQVSEMVTSAANQNSYLKSLELYSPKFGFFGFNDSVLQAADINLHIMERRLPNTKLMNKMVWMTTEQGFDQQRYILGARTIPNFISDDNLGYVMAVLDGTLIEEDFRDIDIGQGGIIFLMNEEGQIVFASSSIQPQQKKLFSATLTKLKNEALDHDIFQVDGVRSLITYSHSNKSGWMTGAVLPVSSLTRQMAYIQKIIIWTNVVAIFFILLSAGVLSSRITKPIRKM...
Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC: 2.7.13.3 Subcellular Location: Membrane Sequence Length: 585 Sequence Mass (Da): 66938 Location Topology: Multi-pass membrane protein
A0A498J8H2
MTMSKQKVLLQPIILLIVIEVLLAAATSAQTQLASPPLPSPPPPSEVEVKPGCQDKCGNVSIPYPFGTKKGCYLNEDFLITCNSTHYEPPKPFFKKSYSTEVTNISVDGKLYITLYPAVICYDKSGQLTYEFTSSVNLSSFFISNTDNVYVAVGCDTYSYICGYKNEKYVYSGGCISYCAGIDDYVVNGSCNGFGCCQTRFTQGINYFEISAMSFKNHKDVYSFNPCSFSFVVQDGKFNFFSNMLGSDYLKNASLPVVLDWSVGSENCTNVVSKKNHPCKGNASCYDVENGSGYRCKCNDGFQGNPYLNGCHDIDECKVP...
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Subcellular Location: Membrane Sequence Length: 774 Sequence Mass (Da): 85610 Location Topology: Single-pass type I membrane protein
A0A7X8XWS8
MSGKKVFSLTKLNTSIGKHLNKVSGAFWIKAEIAQLNFRSGHVYLEFVEKEGDMIVAKSRATIWKGEYQVFEHRLGELLFQVLKQGAEIIAEVEISFHNVYGLSLNILDLDDSYTIGELERKRKLAIEKLYKEGKVELQGKLKLPIVPQRLAIISSAIAAGYEDFMHQLKNNQQGYKFKIDLFETAVQGDKATSMLIEQLKKIQLSNEDYDAIIIIRGGGAKMDLYAFDQYEIGKEISKASIPVITGIGHEKDETIADIVAFLNLKTPTAVAEFLINRVYTYDQNIEILLNNISDDIKDLVEDNRYSFELQVAKLFPKFS...
Catalytic Activity: Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. EC: 3.1.11.6 Subcellular Location: Cytoplasm Sequence Length: 456 Sequence Mass (Da): 52368
A0A831EBW4
MFDIGFGELLLVFIIGLVVLGPKRLPVAVRTVVGWIRALRSLATTVQNELTQELKLQEFQDSLKKVEKASLDNLTPELKESMDELRQAAESMKRTYSANDAEKASDEAHTIHNPVVKDYEAQHEGVTPGVAEHQVSAPQQAPQEVPEETAPAKISLAKTAAPVSDSTPSASDKS
Function: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding...
A0A979FJK0
MTTKVLRSLQVVKKSGSLQCVVCGSRRYSTSTNAESFSTNTSSNTSSTSTNSTNTSSTSTYSRKDAELFDIVVAGGGMAGFAMACSLGQSKVLSSLRVLVLEGGPHTDASLEALSAAPHDNRVCAIAPPSVRLLDKLGVWHDICGVRTGPVKRMQVWDSESDAMIAFGDGHRALAHIVENRVTVAALRARVPSSIEVRYGARVQSFDLPPPATDGLPLLTLRDGGHIRARLLVRGASVVRGASVVRGASVEHLEVWTVCRGGNTAARGTDSLPWWQHCSSRYGQSAVVATLQLEREENESNITAWQKFLPNGPLAILPLR...
Pathway: Cofactor biosynthesis; ubiquinone biosynthesis. Function: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation ...
A0A6B9LZA8
MFINRWXXXTNXXXXXXXXXLFGAWAGMVGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPSFXXXXASSMVEAGAGTGWTXYPPLAGNLAHAGASXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYQTPLFVWSVLITAXLXXXXLPVLAAGITMLLTDRNLNTTFFDPAGGGDPXXYQHLFXXXXXXXXXXXILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFXXXXXWAHHMFTVGMDVDTRAYXXXXXXXXXXPTGVKV...
Pathway: Energy metabolism; oxidative phosphorylation. Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytoc...
A0A1Q3RRL0
MIIDGNAIAKKIKDKARNCCSDCYRKPNVVAIMLGENPSSEAYLRMIERTCNSVEFGYRLDRFDTTLSEQDLLEHIRALNEDEEIDGILVQMPLPKQISEEKVIMAIAPEKDLDGFHPINAGRLFKGEKATRPCTPLAVITMFKELDIDLEGKYIVVIGRSNIVGKPLAVMLMENNATVTICHSRTVDLEEHTRKADIIIVAVGIANFLKKEMVSEKAIVIDVGMNEVDGKLVGDVDFDSMKDYVQMITPVPGGVGPVTNAVLLLNVIEHFKGVK
Pathway: One-carbon metabolism; tetrahydrofolate interconversion. Function: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate +...
A0A498KBC3
MATCPPYVGGQAKAPTPDCCTGFKQVVNNNKKCLCVIIKDRNDPELGLQMNVTLALGLPAVCKAPANVSKCPELLHLDPKSPEAQAFYQLEGNSTKTASSLAPSTTVEGPTIASMGSRSSSGAARQNIVGLLQ
Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues. Subcellular Location: Cell membrane Sequence Length: 133 Sequence Mass (Da): 138...
A0A1F6QPB5
MTRKIDVQVIIGSKSDELKIKPALDTLAEFGIAYDFKVASAHRSPSYVEEIIDSAVNGGVKVFITGAGMANHLSGAVAGRTTLPVIGVPFSGSSLGGMDSLFSTVQMPPGIPVATVAVDGAKNAAVLALEILSIENKDLQKKIIEFRHKETEKIRNAI
Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2. Function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucl...
A0A7R9FJH5
MGLIFDSLYVDVAVGAATLLVLICIFYSYAYGYWRRRNITYIPAPFSIFGNVGDMIFMKKTPALVMRDLYNKLDGEPYGGIFIGATPIMLIRDPEVIKQVFVKNFTSFMDRHLDINEKVNPVEENLFFMKGEKWRWLRSKLTPTFSSGKLKMMFQVLTECASEMNTYVESIASKQESIEMRELFAQYNTEIIGSCAFGIKFNTINNPKSEFRAIGRTIFDQSFFQMMKGLIITIFPGLAKCFTFTIFDLKTSRFFRGIVEDTIAHREKNEISRNDFLQLLIQLKKKGYVTEDSTQLKEDAYLYYKIGDEGSSVRKEFDKT...
Function: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. Subcellular Location: Endoplasmic reticulum membrane Sequence Length: 546 Sequence Mass (Da): 62704 Location Topology: Peripheral membrane protein
A0A7S0WGW1
MPPSTPLEEYLESVSGLPAKIQHNFTNLRELDEKSKKLHEELDQQVQQVWAPGPGQKRSRRTTVTDANAESKLEPFIKQCQQVTEGKVALAMQTYDLVDVHIQRLDKSLRKLEEVVKQRAEKEGVGAKDGQGSSGGSAFDAKRKGGDTDKRKKRDRLTTGGVSLQAPSYTDTGGGEKIDIDLPIDPNEPTYCVCNRVSFGEMIACDNNSCRIEWFHFECVGLSRDHKQKGKWYCPECAALKKKAKK
Function: Component of an histone acetyltransferase complex. Subcellular Location: Nucleus Sequence Length: 246 Domain: The PHD-type zinc finger mediates the binding to H3K4me3. Sequence Mass (Da): 27509
A0A834N216
MVAHILYNFNLEPVDELDNVKIMEDVLLRSSKTLQNNLIPAGSICNISIHNLHRTPEFCPNLDVFNPGRFLPKNIKERNLYSYSPFSAGPKNCIGQKFAVLRLKIIVAYILHNFYLKPVDKLDDVKMIGDFILGSPKPPRIKFISIK
Function: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. Subcellular Location: Endoplasmic reticulum membrane Sequence Length: 147 Sequence Mass (Da): 16795 Location Topology: Peripheral membrane protein
A0A165HE29
MAKTELQVLLENVPDPTDFPSADVAPGLRELDEALVCDVCREFYSGPMILECGHSFCSYCLRRAFSDRQECPKCRAPANEMRMKKNVELESVVSIWKSAARECILDLLKRNQELLIRLDEPAASGTDGVAEGPPQKRQRVDTEGSDDEVQFVSSPLKQPSIPSKVKVRPRNGHGRRPSGSSNSSSPGAPSSADGTNGLVNCPLCQKQVPLECINPHIDSGCQRFIGPGASSSAAASTQPGPKGKQKREWSKLLDGGNSVGQGSGVARKAKEKGKERERAGSMTPDPEYLPKEPYDIIKLSRLKELLQEHGLSTHDERNVL...
Pathway: Protein modification; protein ubiquitination. Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC: 2.3.2.27 Subcellular Location: Nucleus Sequence Length: 4...
A0A3M7SAF6
MSRFDLIERDPKKINNFVQIFFSDVVAEPEFTRSEDTLWSASIELFKCSKNSVYKLFSAVFSIVWSLFCGCCLGLSAFYNVWLWMPCIKYQSFLLRFFKKLNSILLAVCLAPITSVLGLYLSKIGSGSEDDRTPRRFSIQLERIFLPERNSTNLSSKSSTQTKAEFLRNEQENFFN
Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Subcellular Location: Cell membrane Sequence Length: 176 Sequence Mass (Da): 20400 Location Topology: Peripheral membrane protein
D7CUB9
MVFPLGRPARLAVLASGRGSNLRALAAAFPPGDPLGSVVLVLSNRRDAPVLALARDLGIEARFIPFGADRARFEREATAQLTAAGIDLVLLAGFMRVLSPAFTARYAGRLVNIHPSLLPRFPGLHAQRQALEAGARESGCTVHFVDAGVDTGPVILQRRVPVLPDDTEERLAARILAQEHRAYPEAVRRVLLGEARFEAPQNQEATP
Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1. Function: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), produc...
B2V8K6
MSKNLVVLISGRGSNLKAILEAIKSGKINAKVSLVLSNKKDAKGLEIAKEYGIKTKFIDPSFFETRRGYDIYIAELIKKENPDFVVLAGYMRILSDEFIDAFEGKIVNIHPSLVPAFQGKSAQRQALDYGSLITGCSVHFVTKELDNGPVIVQAVVPVLPEDTEESLSNRILEFEHKIYPQAIKWLVEDRVVVSGRKVIVKDAKYGTLPVNPSLEDF
Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1. Function: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), produc...
D7CTI5
MIVVVGSLNMDLVVRVPRAPRPGETLLGSGYETHPGGKGANQAVAAARFGAPVRMVGRVGRDAYGDPLAHRLAAEGIDLGFLEQTDDKTGVAFITVDEAGQNSIIVAPGANAALRPEDLTERVFEGAEVVLVQLEIPLKTALRAAALGRAAGARVLLNLAPAQALSAAQLGDVDLLLVNEHEAATLLGAPEVLGDLGAALAGLRRFVPAVVLTLGGRGAAWAGPEGSGLEPAHRVRVVDTTAAGDAFAGALAAELARGATLEAAVRYAGAAGALAVSRSGAQPSLPTREEAERLLRGAG
Cofactor: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. Pathway: Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step ...
A0A932R599
MLLTLKVGNTTIAAGIFAGEKLVADWSISARRDYTPDELGMILLNFLAAHKIKASQIEGFIVNSVVPPLNWAISKAAHKYFSTEAIFLNNRFGLVPLDVKEPESVGADRIADCIAGFRLYGGPLLIIDFGTATTFNLLSREGHFLGGAIAPTMELAAESLVKTTAQLFKVELSPPRSVIGKDTAENLQAGIVLGFLELVEGLIDRFEEEYPEGLRIISTGGRGSFFKDQIPAIEIHDEHLALKGLRIAWEERNREQKSL
Cofactor: A monovalent cation. Ammonium or potassium. Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. EC: 2.7.1.33 Subcellular Location: Cytoplasm Catalytic Activity: (R)-pant...
R7Y090
MSERLRPRDLAFLATESSRTPMHNATVEIFDPGESGFDYARLVELIADRIAFVPRYRQRLQWIPGRLATPVWVDDPEFELSYHVRRSALPRPGGHDQLRELVARIASRPLDRSRPLWETYFVEGLAGGRVAVLTKSHQILVDGRETVDIGQVLLDTEPDRPELGHDEWHPRGRPDALSLTLGAITDSIERPSTLVKTVQANTQSIVRTASSARHRASDVAGALAGRKPVASSPINGPLSRQRRFLMIHTQLDDYKRIRRVHGGTINDVILATLTGGLRGWLMTRTESMAGLKTIKAIVPMSVIDDELEPTSLGTQVAGHL...
Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis. EC: 2.3.1.20 Catalytic Activity: a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA Sequence Length: 485 Sequence Mass (Da): 53248
A0A089K729
MARVRSTAEKLKRWLADLSIQIKLIGAYIVIILVPVIVISNYLFTGFYQNTIKDIIKENRYQTDNEKQEIMSRIGVMEQSIGLLVSDRQLREYVTVESEPGLNDIKRFQEYSFTYLQTVLFNNSDIANIHFFVNNPWISELWPIIYHEERIKDKPFYTKMLNQTGNVLWEIQSEDAILQDSNAAVNQSLSSIVSLMAGVNQMNSQNLFQHLGIVKVDMPIGNFFKKAYNNSSDRDSRFYILDQQGNLHANSTDPLAGLDEADIQPAVAKYKEAGKSSLLLSHKGEDFLYLVEHIDKINAELINVISLHTTYSKIDQTRNT...
Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC: 2.7.13.3 Subcellular Location: Membrane Sequence Length: 636 Sequence Mass (Da): 72420 Location Topology: Multi-pass membrane protein
A0A5C5VEK7
MSEADHPDRAPLVDSFGRRHTSLRLSVTDRCNIRCVYCMPDEQLRFLPRQEVLTFEEIERFTRVAAWLGVRKVRLTGGEPLVRCDLPALVRRLAGIHGIDEVALTTNGVLLERHAAALQDAGLTRLNVSLDSVRQETFVRLTRRDVLPEVLAGIEAAQHAGFEPIRLNAIAMRGVTEEEVVPLGRFARERGLELRFIEYMPLDADANWRRDQVLSGDEILSRLEQAFGALEPTHREDPSQPARDYRFVDGGGVVGFINPVTQPFCGDCNRLRLTAEGQIRNCLFSTEEWDARAVMRSGGTDTQLAQQVRDAVAAKRAGHG...
Cofactor: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate. Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. Function: Catalyzes the cyclization of GTP...
A0A834JJN1
MRNYVQTRDATCTLYSRCFEDNATSDARTDDASFIAENVTDVNVDWGMVFRGMVVSSSQLFSVDNVVAGAVIYLAVLIYSPATAGFSFAGVFIGLELGAPHKEVFTGLWGFNCFLTGAALGGNLFVINVQTAAATLVAIVYTVVLQYVLRIIFGKIGLPFLTLPFVISTSLFLKLRSASSSAVFPKPLQSSYPEKQRHDYLINRKRILQENVDGGSGGGSGSGSSGRRCGVKCGGGRQAVVGRGACIRGGEELNASLPKRLPAQRTSLSATRQYSPQDTFYPVVTNNVLQRGGGFPRPLPPNDQKDKENKEENEVSRPGS...
Catalytic Activity: urea(in) = urea(out) Subcellular Location: Cell membrane Sequence Length: 322 Sequence Mass (Da): 34598 Location Topology: Multi-pass membrane protein
A0A351JX75
MAQGSRGEDRGRGSGGRGGGGQGSVRDRVPVPRDARPGPRGRRPNYPPGRADRLPEGGVRTVLHAALGRIRYGPALAIQHRLHALRREGKVGDVVLSLEHESVITIGRRGDEVHILASREDLERAGVEVFPVERGGDVTYHGPGQLVLYPILDLRERGKDLHRYVGEIEETMVVTARTFGVEAVRREGFPGVWHARGKLGSVGIHVRDWVTMHGLALNVDLDPDGFRWIVPCGIVGANAVSIADLAGVRISVAAARDAACAAFANVFGVELLPVDGEVIAGWTRESRTG
Pathway: Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2. Function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-A...
A0A3D0DVF7
IDAAVAAATAGSGAAPGPKATHVVPPKAELLIYPVMKIDRVPEAAGKQESELNALDVVEVVDHYELAYHVRTRMQRANKPLYFDTIVSAKDAHIIDRWSMLQTVIGVGKSQYNGEVPISTTQVGDTFQMRDPERGTGGAYGAMAITNANNTSNAGKMYTHTTNTWGDGKQYVRGGSTTDANGQTAAVNAMWGLMNTYDSLKNVLGWQSLDGHNTASYIAVHVNTAYDNAYYSDTCRCMFIGDGSTFSSLGAIDVIGHEMGHGVTAATSNLVYSGESGGLNESSSDIGGEIAEAYARAGGKGEAIPNGGNDWMLGSEIGRN...
Function: Extracellular zinc metalloprotease. EC: 3.4.24.- Subcellular Location: Secreted Sequence Length: 456 Sequence Mass (Da): 48664
A0A0H2XST3
MRRSGRPSQTETCSTSFSSPPEIPPNTGNVIRLCANTGAHLHLIEPLGFPLDDARMRRAGLDYHEYAQMRVHRDWDAFVAAETPDPARMFAFTTRGSGRFHDHAFLSGDWFVFGSETRGLPAELLERFPNEQRVRLPMRPDNRSLNLSNTVAVVVFEAWRQAGFEGGA
Function: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. Catalytic Activity: 5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adeno...
A0A7S0RYH0
MNEENCLLAQNLVSKAYISQGSDALARRNKLIKRLLSNRRLPPEGWDDATIEMFIQDCALMDSNNFVDVVGVGEREGRVASNLVAQRHYRLAHGIGRSGDLVAEQPKAAGSSLLAKLSNLLVMDALRVAGMEDLGAATILPMATGMAVTMVLLALRAKRPPTARYVLWPRIDQKTCAKAVATAGFELIAVPMCLEGDLLVTDVAALENEIHTRGADNILCVLTTTSCFAPRGPDDVIAVAKLCAKHGVGHVINHAYGVQARPLNAQVAAAWRRGRVDAVVQSTDKNFMVPVGGAVVAAGQSDPSLVQTVAQMYPGRGALT...
Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2. Function: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. EC: 2.9.1.2 Catalytic Activity: H2O + O-ph...
B9XP92
MILLAVETSCDETSVAIIRNGKVLSTIVSSQIKLHAEYGGVVPELAAREHLANLIPVANAAMTAAEVQSDQVDAIAATQGPGLPGALVVGLKAAQGMAFALNKPFFGINHHEAHLYSPWITGSPPVADFDSFQPNISLIVSGGHTMLIHVESELKHHVLGSTIDDAAGECFDKVAKLIGLPYPGGPEIDRLASAGNPKAYDFPRPMLRDASDDFSFSGLKTSVRYFIRDNPAVLDSLQKLQDLCASVQEAIVEVLVTKTVRAANRLQVKCVTASGGVTCNRALRSALETACKRKHLTLRLAEKSLCTDNAAMIGVLAERK...
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, togeth...
A0A2R8C282
MSVEAGVVTLEGRVADPAVSQDVAGIAERLEGVVAVDHALAASDDISQQINPAFERFRARADQFFARLPLFFLAAAAFAAIVVLGILLTGLRFWDRIAPNAFIAGIYRQAFRVLCGIVGIVVALDLLGAAALLGTILGAAGIVGLAIGFAVRDTVENFVASIMLSLRQPFRPNDLVEIEGDVGRVIRLTSRATILLSLDGNHIRIPNALVFKGRIVNYSQNPARRFSFDIGIDPDADPEATRVLAQAALKAQSFVLDDPEELVWIENITESGAILRVTGWIDQNETGFVTARGDAIRLVKAAIEAAGVSIPDTTYRIRLE...
Function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens con...
D7CY84
MNVLVYGLGRSGGAVARLLRRQGHAVWTFDAQHPQGEDLAALGCRATSAPLEVPAELCIAAPGVPWDAPDLAALRARGVETIGEVEWVYRTVDAPILGITGTAGKTTVTRWLSHTLTLAGLDAPAGGNVDPALAAVAAPGRVLVTELSSFQLERCPSLHPRVAVVLNLGRDHLDRHGSLAAYHAAKKRLIAHLTPEDTFVYNHDDPLVRAWAEASPARTWGFSAAPTPGSAAHLADGMLTLHGRPLVAVRALQLTGQHHRLNALAVALAAAAWGLGDEAIRAGLESFSGVPGRYSVVGEVAGVRFVEDSIATRTLAVQAA...
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Catalytic Activity: ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-...
A0A3B0PG01
MNNNQQKTNNNNQKNSVDKSENDNNKKKSEANQKQENLNPNNNNKKKEDSKNESNNIPLINKNISDQQIVKISNYIKDNYPVIYADLKEKNRLGFNSNLDDDKLIVYANYEDKDLELLLKKFKVVTNNIGLYEEALTHNSYANEMHLKYNYQRLEFLGDAIINKIVAEYLFNHSDSSEGEMTKDRIKIIQSNTLIKAATQLELINYIRVGEGLKIAPLSPKILEDIFEAFIGAMYLDQGEYAVRKILNYTIIGYYQKGQLTENTDYKSIFQEIIHSTGLNMKIHYERTYDRQKNLHTVSLYAGGIMYGEGKDSSTHKAEI...
Function: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the o...
A0A7V1KMZ7
MSWLNLLAVAALGYLVGGIPTAYLAGRLRGIDIRTQGSGNVGGTNALRVMGWRWGLPVMAVDVGKGYLATRLLPALSFSPLEGVHLAIAAGVGAVLGHIFSPYLAFRGGKGVATGAGMLLALIPGPVGICAVIFLAVAFGTGIVSLGSLSAGAALPLVTWLWGRGVTPVPPAVHWLTVALALLVFWTHRSNIRRLLQGRENRFRRPWERRS
Pathway: Lipid metabolism; phospholipid metabolism. Function: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. Catalytic Activity: an acyl pho...
D7CWV7
MTQRSFTGILVLGALLAAVLYLWQPWNTTGLPPLRLGLDLQGGLRVVLQSTTPNPAPEDLQAARRVIENRVNEFGVAEPLVQTAGGDRIIVELPGLSADEQDRAQDLIGQQAVLEFRLVRPQSVGMPVEAMTEADLEPPAFTGEILSGAQTGYDELGRPVVNFQVRGADAQAFGQFTGANVGRSMAIVLDGNVVSAPTINQRIDASGQISGRFTLEEASDLALVLRSGSLPIALQVQEIRAIGPTLGADSVAAGTRAGLIGAVAVVVTVLLFYGPLFGSVLTVGVLFALVLIFGMLAGLGAALTLPGLAGLVLTIGAAVD...
Function: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. Subcellular Location: Cell membrane Sequence Length: 740 Sequence Mass (Da): 77357 Location...
A0A830GDC3
MHVGVLGAGSMGSLFAGLLAADGAATTLLAHEGPHVDAIRERGLRIECVDGSSDAVGVEVVTDPAAAPSLDAALVFVKSHATADAADEWRGALADAHVATLQNGLGNAETLAGRFESVLAGTTSHGAVVADPGVVRHAGVGDTRLGRWDGPTDDAPARLAATLSVAGIDTAVVTDPRTALWHKVLVNVGINASTALARVENGALAEHASGSRLLRRAVAEAARVARAEGVDVGDPIAEAVTVAERTASNVSSMRQDVEAGRETEIEALHGAVVARAAEHDLPAPVNRTLADLVRLAQAASERGHP
Pathway: Cofactor biosynthesis; coenzyme A biosynthesis. Function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. EC: 1.1.1.169 Catalytic Activity: (R)-pantoate + NAD(+) = 2-dehydropantoate + H(+) + NADH Sequence Length: 305 Sequence Mass (Da): 30980
A0A3P1Y3L1
MQNDDVKRIKERLDILEVIGDRVRLHRAGRGYLGLCPFHDEKTPSFHVSQERQNYHCFGCGRGGDVFTFVMETEGLEFRQALELLADRAGVALTRPEGRRRTSGNLYEVMDLAEKFFRSLLTAPEGTAVRAYLTRRGLSLDDAARFGLGWSANSWDSLSRHLRGAGVTDREALDAGLVLEGQRGGVYDRFRGRMTFPIRDVAGRVIAFGGRLVDGEGAKYINSPEGAIYSKRRNLYLLHEARGSIRERGRSILVEGYMDAIRLHLNGYTETVASLGTSLTEEQARLLKRFGDRCYICYDSDTAGQEATLRGMYTLQGLGL...
Cofactor: Binds 1 zinc ion per monomer. Function: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. EC: 2.7.7.101 Catalytic Activity: ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate. Sequence Length: 576 Domain: Contains an N-termi...
A0A1Q3RDJ9
MDFHTHTNYSPDSKTDMKKSILTAIEKNITDLAFTDHVDFDADIDSGIGDWDFDRNKYEEEIKFYQAKFEDQINLYHGLEIGVQPHLTDRNRDVVKMNQYDFVIASLHSVERRDLYHKKYFENHSDIDAIRIYFESYFESVKTFKDYSVLGHLDLYVRYKEELENVAFHKYNDHVEALLRMVIEDGKGIEINTGGYRYGLKYANPNRSFLELYKELKGEILTIGSDAHTPDFLGHKYDETVHLLKEIGFKYVSIFEQLKPKFIKL
Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9. EC: 3.1.3.15 Catalytic Activity: H2O + L-histidinol phosphate = L-histidinol + phosphate Sequence Length: 265 Sequence Mass (Da): 31326
A0A2N7WPE5
MKIAAIETFEIRIPYRRNHTLSSGPLYGAHSVIVRLQTDEGLIGAGEASIPGGPVWSEESVSSVRAVIEEYLAAAVIGRDPLQCSDIAAVMSKAVRGNPFARAAIEMACFDVAGQALGVPVAQLVGGRRRSSVPMVWSLASGVVEQEIEEAQGVNQRFGISRFKVKVGHVDAAADLERVRTLMRNVPENFQIRLDANQGWNEMTANWALPRLQDLGVTILEQPLPKGDLAGMARLKQQGRVAIMADESAMNANDVINIIRNASADMIALKLAKAGGILGTLQSASVADAAGLPYYMGCMMDTGLGTAAYLQTASALKDMS...
Pathway: Aromatic compound metabolism; 3-chlorocatechol degradation. EC: 5.5.1.7 Catalytic Activity: (2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate + H(+) Sequence Length: 371 Sequence Mass (Da): 39483
A0A5C6MBV9
MSVAADCDRDTLLIQVLPRGPVCHLGTTTCFGDDSRSNFSAISQLEQTIEQRRKAGADNSYTAKLFIEGRDRITQKVGEEAVEVLIASKNPDDRQFIGECTDLIFHLTVLLVEHGLSWDSIYSELNKRSK
Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide EC: 3.6.1.31 Subcellular ...
A0A5C6M538
MVAVIDYGMGNLRSVFNAIEILGFSAELVKDPEKLQLYDHVILPGVGSFRVCMDNLQKTGFDQSIKEYVQTGNALMGICLGMQILATRGFEDGESLGLDIIPGVVEKINPLDAKIKIPHVGWNDVTFNSIGNPLIKSMKNSETFYFTHSYILKCDNLNYVFGETIYEKSFTSAVLKENVFATQFHPEKSQDVGLKLFKNFINWTP
Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthe...
A0A5C6MCQ3
MSTDPANPTRRELLSAFRTRTAAPSESARIAGPAPNGGATVRLTARLMGCDFTVVLNPGPEQVEVAGEALERISAVEAWLSHYRDDSQLSRLNQTGWPGPASISAELRDFLEFCRHCWQLTDGAFDVAAGALSQLWRHCRKAGRIPDDAAVAAAKACSGHSLVNMNPVGNTVCFSAAGISLDPGAVGKGWGLDDAAAWLLDRAEPLQNFLLSGGHSSLLAAGSHNGTGGWPVGLGNPLFTEKRIATILLMYQAMGTSGSNIQFFRHAGRRYGHVLDPRTGWPAEGMLSATVLADSAALADALSTAFFCDGSGKGG
Cofactor: Magnesium. Can also use manganese. EC: 2.7.1.180 Catalytic Activity: FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+) Sequence Length: 315 Sequence Mass (Da): 33073
A0A1W1UVF9
MKVNHLDYHVEVQGAGEPVLVLHGFSGSSKSFSKFSDLWSQDYQVILVDILGHGNSAKPADYRRYEMDKVAEDLKVILKNLNIAKTHLFGYSMGGRLALNFVFKYPQMIASLILESSSPGLENEEERELRREQDYELATFIEEKGIAEFVSYWDSLPLFNLKEIAKEKKNALHQERLNNDTKGLANSLRGMGTGRQKPLWHALQEIKVPVLLIVGEKDKKYCKIAAEMAKRLPNAQKEVVQEASHIVHLEKPHIFSNLILEFLQGRYKNDN
Pathway: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 3/7. Function: Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation...
A7SRZ2
RKSNFKITSWNVNGLRAWLKNNSKSFVSKEDPDVFCIQETKCALADIPKEAKLAGYHCYWNSAEQKGYSGVGLCSKKEPIKVSYGMGNKEHDKEGRVITAEYEDFHLVTSYVPNSGRGLPRLGYRQQWNKDFLSYLKKLDEIKPVILCGDLNVAHKDIDLANPKTNTRTAGFTKEERADFTTLLGEGFKDTFRELYPDKKSAYTFWSYMGGARAKNVGWRLDYFVVSDRLVPKVCDSIIRSRVMGSDHCPLSLLLSI
Cofactor: Probably binds two magnesium or manganese ions per subunit. EC: 3.1.-.- Catalytic Activity: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates. Sequence Length: 257 Sequence Mass (Da): 29231
A0A1C4IA83
MRQPAYPQGQDPYATPEAYPPPQPPGERGPQPPQAPTAQVAQAQTQAPAPERGEWDPDPDEPEHPFFASDGDAGRATGRRTKGRDDDRDDLADDEDGDGDGRAGRRGGERPKKRRGGCACLVVAVVLIGGGGGAAYYGYGLYQDRFGPPPDYAGEGSGTVVIEIPDGSTGIAMGNLLKDKGVVKSVEAFTAAQKANDKGTTLQSGFYTLHKGMSGKSAVELMLDPKSRKTLVIPEGYRNAWIYAQIDGRLGLKKGTTADVAKSDRKKLGLPKWADDDKDIKDPLEGFLYPSTYSVSKGQKPADVLRKMVAQANKQYEKID...
Function: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. EC: 4.2.2.- Subcellular Location: Cell membrane Sequence Length: 469 Sequence Mass (Da): 50612 Location Topology: Single-pass membrane protein
A0A6A2ZCF9
MRTGWADGPEFVTQCPIRPGGSYTYRFTVQGQQGTLWWHAHSSWLRATVYGALIIRPRDGESYPFPKPKRVTPILLGEWWDANPIDVAREATRTGATPNVSDAYTINVQPGRDLFKCSSEETTIVPIDFGETNLLRVIDAALNQPLFFKVASHKLTVVGADASYTKPFTTSVLMMGPGQTMDVLIQGDRPPSRYYVAARAYQSAQNSPFDNTTTTAILEYKSATYAAKNCKATTPVMPSLPAYNDTNRVTAFIQSFRSQQKVEVPTDIDESLFFTVGLGLNCPPNFHKRRCQGPNGNRFTASMNNFSFVLSRNFSLLQAH...
Cofactor: Binds 4 Cu cations per monomer. Function: Lignin degradation and detoxification of lignin-derived products. EC: 1.10.3.2 Catalytic Activity: 4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O Subcellular Location: Secreted Sequence Length: 451 Sequence Mass (Da): 49830
A0A932R794
MKNNSLGVVILAAGRGTRMGQITPKAFLLLEHKPVLLYSIDLLARVEYVDEIIIVVHPEDRQHLENKVLSSLSVKKRIHVVEGGAQRQDSSLSGVRATTSSWVAVHDAARPLFSSQLLDRVYRAAQEAQAAIPTLPVTESLRLVSKESLITTDVNRENLHLVQTPQCFARELLLRSLEQVCAERRYFTDEAGAVLAISGVRAKAVPGERANLKITLPEDLEWAEALLKIKSRAA
Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). EC: 2.7.7.60 Catalytic Ac...
A0A3A9JDS4
MRQKVMRRLPRRHLSMPRRYGLAALMVLAAGGIRLALPVIGPPYLFFIPPVMAVAFLLGNGPGLFATALATLLAVGLFIPPYYTLQIPFEQWTATALFALVAAALALVCSAFRRTLDARDADLAQLRQALADAADGRAAADASNAFLSGVLASSADCITVLDLDARLTFMSEGGRRSMEVANFATIHHAPWPELWQGEARAEAEAAVAEARAGRAARFQGLAHTMRGRPLWWDVAVTPMLDGDGQPERLLCVARDITAQRRLEEQQQLLNQELKHRLKNTLAMVQAVMNQTLRQSRSLPEAQEALEARLVALSGAHGGLL...
Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC: 2.7.13.3 Subcellular Location: Membrane Sequence Length: 470 Sequence Mass (Da): 50987 Location Topology: Multi-pass membrane protein
A0A1F3ITE7
MVRLFRKKIANELSKSIKNIFGFRPGNIFLYELAFMHKSAHAERNGREISNERLEYLGDAVISVIVADFLFKKFPFADEGNLTEMRSRVVSRNSLNKIAEKLGVGRLVTMSSVPVSNAYTGNALEAFFGAVYLDKGYSFAQNLLINFIFGRRIDVDAFINTETNFKSKLIEFCQKEKSSLDFSIVEEIQAGRKKQYVCEARINGEARSRGIDYSIKGAEQNAAEKALEVLRNGAE
Function: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the o...
B9XIP2
MKVLVIGGSGLVGSHVLKAALAAGHQAIGTYRRSPLSGLVPLDAGDAAAAGKLLDQEKPDAVVHAAGWTWVDGCEDDPKRAFAENAEQPANLARLCQKRGIHFTYFSTSYIFDGLDGPYDEDAKPNPINVYSQSKWEGEQRVQQETDGTALLPRIICVYGAEVQKKNFAYQVWNALREGKALTLPSDQCGNPTYAGDIARWLITLLEKRERGPWHLGGPWPTCTRPEWAEKLIAAFKAEGIISHPNFAVKTLPTADLRQKALRPLRAGMISMKAFGGEFESTEFNQTIRELVANSI
Pathway: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis. Function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. EC: 1.1.1.133 Catalytic Activity: dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH Sequence Length: 296 Sequence Mass (Da): 32417
A0A178MXK6
MFVLSAVGILLISAATVGYISFANSRDAIAVLASEFRRELANRVVDHLRVFLEAPQNILRENAANLAEGILPTDDPGAISRHFLRQSLIHPSLSSLYFGNTSGGLAVGGHDGRREVLYTITTDGFVAGRFNKYRADPDGSRQGLIQSLPNYDARTRPWYRSAMASGDGVWGPIYILFTGDDMALPPSRAVRDTSGRLLGVVGADLFVAQLSRFLSDLHSRAPGQTFIMEADGSLVASSTGEPPFTRSQEGQPGHRLKATASSNRLTAEAASLVLTEDKRSGHSLRLDSAQGRHFVEVTPFHDPRGIAWTIATVVPEHHYM...
Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC: 2.7.13.3 Subcellular Location: Membrane Sequence Length: 804 Sequence Mass (Da): 88012 Location Topology: Multi-pass membrane protein
A0A2H6K5L7
MHLIVGLGNPGSEYEGTRHNAGFMAADRFRVTRELGRTRRRYQGRWCEGRVCGRDVALLMPHTYMNNSGEAVRAAAVRKHISPEEIIVIHDDMDFPFGTVRVRAGGGTGGHKGLESIAALLGTTGFARVRIGIGRPENPFIAARDWVLSDMGVSGDELVAVLDTAADCAEAIIIDGMEAAMTRFNRRNDDKV
Function: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Catalytic Activity: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+) EC: 3.1.1.29 Subcellular Location: Cytoplasm Sequence Length: 192 Sequence Mass (Da): 20953
G9PE34
MLPPQPPVAGRQSASADPWRIWTIPNALSALRLAFIPVFALSIWQGHMLSAAIILVLASVTDFLDGVIARAFNQRSRLGRLLDPAADRLYIATALIMLAVVGALPWLVMVLLLARDVILAVHVPIFAHYGYAPISVNAAGKVGAFMLMSAFPLLLVRFAWVSTSIWAQITYSAGVATLIWGAGLYCWSAFIYLKQITRVLSEAVK
Pathway: Lipid metabolism; phospholipid metabolism. Subcellular Location: Membrane Sequence Length: 205 Sequence Mass (Da): 22301 Location Topology: Multi-pass membrane protein
A0A809RDA7
MNSIRQRLLLWLIVGMLISTGIAGLSMYLLAQDEANELFDYQIKQIALSLPGSSQLPVVTADDEDPEEDNVIQVWDAQGKPLFVSYPSRALPRYVATGLHTVNYRQQPWRLYNTQRRGQFIQVAQPMTVREELAAALALRMLMPFFVLIPLLAGLIWWSVGRSLRPMQDVTTALATRHADAMQPLDETDLPQEIKPMVIALNQLLMRLDQAMQSQRAFVADAAHELRSPLTALKLQLQLTERTSGDEQRTIAFTKLNQRVDRSIHLVQQLLTLARSEPRLEQAQFTDVDLSALAYEVAQDFMPLAEAHQTELRLELQPDV...
Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. EC: 2.7.13.3 Subcellular Location: Cell inner membrane Sequence Length: 432 Sequence Mass (Da): 48362 Location Topology: Multi-pass membrane protein
A0A6A2ZVH8
MPMATDVIASLDISFVSCCSLFRRGCRQRRVGGVVFYVLGVTSTSSCHRVAAWSNGVGKALSMQAHPDKEMAKELHKMNSNLYKDDNHKPEMALAVTTFTALCGFISLHELKQVLEGVHEIVQVVGIASAKQVMDIHDRGGAPTDEVKSALRSVFTQLMSASKEMTTTVISKLKSRLLVESQAGEALCLAANEPHAYLSGDCIECMATSDNVARAGLTPKHRDVQTLCSMLTYNQGYPEILSGLPLSPYITRYLPPFDEFEVDRCVLPTGSSAVFPAIPGPSVFLAFAGEGTLKTGSCGGIVTEGDVMFGPANTEITITA...
Cofactor: Binds 1 zinc ion per subunit. Pathway: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2. EC: 5.3.1.8 Catalytic Activity: D-mannose 6-phosphate = D-fructose 6-phosphate Sequence Length: 342 Sequence Mass (Da): 36736
A0A931LLF3
MNPTQIQREKKPWLSLLLALLAGTLTALSQPGYGLDWLSAFSLIPLFFALDNSRAKAAFFSSWLAGFVFFAILLYWLFFLSDWAGPWIALGYLVLCSYLALYWGVFGWLYSVLQKSVRGLHWLAVPALWVSLEFVRSLTHYGFTWGYLSDSLYAQPKLIQIASITGAWGVSFLIALVNLLFFWALKHRQVRFVLAGLGVITLALLTGYFLVNSEATQTVRSLEIAIVHSHVNQLDRSSPSQTDRLVELYASQVEQSVQGPVDLIVLPETILPAFILRNPEVFSRFSSLAIAKRAWMIVGTIDYRLDHPGALYNTAALLSP...
Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipopr...
A0A931LMB7
MARSKKSEWIEVFAPATVANCGPAFDTIGFSLDTLGDCLEARLVDKPGVHIAEITGTKGLSTDPTKNTAGIAAQETLKLAKSLSQGVEIRLHKQIPQGSGLGSSAASAVAGAYAVNILLGEPLSQEELLEPCLAAECAVSGYFADNVAPALLGGFVLIQNLKPLRLVRLPVPDKLIVTAVTPDYVLLTREARAVLPEKILLKQAVRQWANIGALVAALHQNDLKLLGEAMEDFIIEPVRAPLIPGFDRMKQAALAAGALGCAISGAGPTAFAITDDLTKAEKIAQRMQAGFAQVSLKSQAHIGRVSTQGARCLRGKNR
Pathway: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. Function: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate. Catalytic Activity: ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine EC: 2.7.1.39 Subcellular Location: Cytoplasm S...
C2MBE5
MDDLVISELIALLQAHGVRDVVLCPGSRNAPLVHALSHYLTRATCHSIIDERSAGFYALGLALATHREVVVCCTSGTAVANLHPAVAEAYYQGVPLVILSADRPERWIGQWAGQTLPQPGLFGSLVRKAVQLPEPHTDEERWYCNRLINEALLVALAPLPGPVQINVPISDPSVSLLPPTPAEQQSDPSDRRPIGMQSGRHIKQCCPCGVDAQAVKPLLERLATFERKMILVGQESWTATTSAGAVFPQSLREQFLCIGESLSNRPVTICSLDALLASLSEADRRALQPDLLITLGGHIVSNKIKQYLRNYPPRETWHLS...
Cofactor: Binds 1 thiamine pyrophosphate per subunit. Pathway: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7. Function: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting s...
A0A418XV42
MAKKTNKTPARSRGQAQRKKSPSRKKAAAPRRRWFSWAFVAKFSLVLLVIGAAGLAYLDAMVRERFDSHVWQLPARVYARPVELYEGRVLSREDMLKLLDLMRYRRDAAASTPGSFAVQGSRLLIHTRGFKDSDGGETPKRIRISLSGGQIRNLDAGGDGLARLEPLQIGSIHPQHAEDRVLVPLEQVPPLLVDMLVATEDQSFYEHHGISLRGLARAMVANVKAGGLVQGGSTLTQQLVKNFWLTSERTLSRKLLEMPMAILLELHYSKQEILEAYLNEVYLGQDGARAIHGMGLGAQFLFGRPLEELEPHQLATLVAL...
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-term...
A0A1I4C589
MTAYTATVTVRLKRGVLDPEAETTKRALDRLGFELQGLRATDRYEIDLDAADADAAEERASEMADRLLANPTIHDYEVEVEEAEE
Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. Function: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent ...
A0A0M4FVZ8
MEIYLDVIWLLNFCFDLLLLSLTGKILKRNVKKFRLVLGALIGSGIVLIMFTPFSWFVSHPAGKLAFSLLIVFAAFGFKRFRYFLQNWLTFFFVTFLLGGGIIGAHSLLQSDGQLENGALMTASSGFGDPISWIFVIIGFPILWIFSKKRIEDIEIRKIQFEEHVNVQVMIGGQEVFLKGLVDSGNQLYDPLTKTPVMIVYAECLKPIVGEAFLELVKTGDSVHALEQIDETFPFIDRLRLVPYRGVGQQNQFLLSIKPDDVLVYTKEEIISVEKCFVGISPSGLSSDDDFQAIVHPKMLSEKGIKHVS
Function: Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. EC: 3.4.23.- ...
A0A7C2UHX8
MADANARSLDIAELIRRHPAEIAEILAALREEEAVELLRRLYRRRAAAEPLGEMEPDEAARLLAELNREDAAHILSHMEPDDAVDLLAELPPNMVQDILSRLEAREAKELGELLAYPPDTAGGLMSTEVVALAEEMTAEEAIQELRARAEEAETVYYAYVVDDRGTLLGVLSLRDLVLARPDTPLRAIMKSDAVALPVTMDKEEVAHVFDKYNFLALPVVDEGRKLLGIVTIDDVIDVIREEATEDALRLGGIPAGEDHPLDPPQSSVRKRLPWLMGLVVLNMSVAGLISQFEATIAQIAFVASLMPLIADMSGNAAAQA...
Function: Acts as a magnesium transporter. Subcellular Location: Cell membrane Sequence Length: 438 Sequence Mass (Da): 47260 Location Topology: Multi-pass membrane protein
A0A5C6MAB6
MGYRFKDRAQLYQALTHRSAIMELSSSGVCSDALPWNERFEFLGDAVLGLAISRRLMDLGQGLVEGELSRIRAALVNEVSLAVVARTLDLGRFLVLGKGAAKSGGRKRDSLLADGLEAVIGAVFNDGGFAAAEAVVDVLFGNVLRGDLMHLVQTDFKTMLQELTQEKFKKVPSYEVLLETGPDHNKVFEVRVILGTEELGRGSGASKKRASQAAAQQAFSKLSNEGEGEETP
Function: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the o...
A0A1W1VM25
MDIRQQRKWDHLKLSLQADKGPLKTGFDDIYLIHQALANTNFNDVNCSIEIFKKKIDFPLIINAMTGGADGLDIINKKLANIARTCNVVLAVGSQTSGVLDRRTRHTYEVVRKTNPDGLILANVSALVDVKIALEAIEMIEANAIQLHLNVAQELAMDEGDREFEKLEENILKIKEKSNVPIIIKEVGFGLSKETIQKLTQYNINYFDIGGAGGTNFASIEVKRSKNPKDDIINWGIPTAISLVEALSVSKNINLFASGGIRSTLDMVKSLTLGAKGVGIAEPILKDVYINREKEVIVFLQEMKKQLKKLMILCGAKNIP...
Function: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). Catalytic Activity: isopentenyl diphosphate = dimethylallyl diphosphate EC: 5.3.3.2 Subcellular Location: Cytoplasm Sequ...
A0A1H2XLL5
MRLSTLAARCASIAAGVFTAGRAFADDQLPELPVIGAPVPGGMHFQQPVTGTMQSAVFLDNLLLWIIVPITIFVTGLLIWCIVRYNQRANPTPARFTHNTAIEVTWTIVPILILFVIGAFSLPILFKDQTIPQADVTIKATGYQWYWGYEYVDHDVEFSSFMLAREELEENGYAQSEYLLATDTAMVIPVNKTVVVQVTGADVIHSWAMPSFGVKQDGVPGRLAELWFMAEEEGIYFGQCSELCGISHAYMPITVKVVSEGEYLAWLERQGATNMAAAPGADTLRVAAAAD
Cofactor: Binds a copper A center. Function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). EC: 7.1.1.9 Catalytic Activity: 4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(...
A0A6A2YRR7
MLAEHIVQLIAAVKPPLARLRRDGLGWRWEANKSFTTKSAYHSFTQPEDSWLNWKIIWKVEAPQRSAEVWAMRLIDLLIVALIPVTKVLSVTGVGLFLALDHVYLLGPDARNHLNKLVFYVFGPSLVAINLAGTITFDSFLTLSSAFAWILIKITKLPSTFKAWSSAVVLLLPLILVPAVCEEPNNPFGDSSTCSANAGAYASLSLAVGAIFIWSYAYAIMRSYANSCKQDSLAITIDTFKETTSESFSENCRIDRRDSLAIRQLLNGADAPLRGANSCMHDLASGSKSSKGLKRTRHESFNYSAVRNILMPLFGVGVVR...
Function: Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling. Subcellular Location: Membrane Sequence Length: 391 Sequence Mass (Da): 43154 Location Topology: Multi-pass me...
A0A1Y5L7G9
MTAAAADRMSSLDAFFFYTEEDGVNHMHVGGFALVEGAAPTAIEVAQALLPKLDRIPRYRQIAQPVPLHLGRPVWVDASQFDVTRHVRSTVLPESSRAALRTELETFISQPLERTRPLWELLLIDAVDADHWCIAWKIHHSMVDGVSGTELLTILFDSAPSPSSPPTVLRAQEPRKLASKQAIVLSSVTDLVLGASRTVHSIRPATARKLSRVGQAYLGLVKQTIFPDLHSPLVGNIGPERSYDYCVVPFADIKEIRAGLGGTVNDVVLTAVLKGFSAVLTAHGTNVSGKSLQAMVPVALRPRDAQGRPLGDGTMETKAS...
Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis. EC: 2.3.1.20 Catalytic Activity: a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA Sequence Length: 469 Sequence Mass (Da): 50533
A0A1W1UZZ9
MRQAKVKTYAKINMVLNCLYKRDDGYHEISSIMQAISLHDNINLKPAGEIILNSNSTLIPLDEKNFAFKAAQLVISKYPSIKGVEIYIDKKIPIEAGLAGGSTNAAGVILGMNKLFNLKMTTSEMIEVAEQIGSDVPFGIIGPTALSTGRGTNVSPIPEAPLLWVVLLKPDFGVSTPKVYSNMKEQMFEKTDNIKGFLGALERKDQDYILGNLVNTLEKSTFALYPKVQEIKDFFIRNTKHSLMAGSGPTVFALFPNEIEAINFKDSIPPDYGKAYLAQTIDSKEIHERVIIDEKEN
Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. EC: 2.7.1.148 Catalytic Activity: 4-CDP-2-C...
A0A3M7SML3
MFKEIKISSPGKIILCGEHAVVYGKKALACSVDLRTTLTASHTSNNFFQLILINLNKTVEIKKEDFMSIRSSPISSEPNAIINHLEKVENDKIVSSLKFFILLDPDLEWSKIAGLQVLVSSEIPIASGLGSSASYSTCLSSLFFVLGSNRVFSESDLETINRNAYYIEKFFHGNPSGLDNSVSTYGNFVVFEKGQIREKFTSDQKLNVLIINSQIPKQTLEQVKKVRSLYEKHTAVLDSLMNTVDILVDKFVQSLKEKSSLDGIKDLVTINQGLLYALQISNQSLNSIVNICEKFGFGAKITGAGGGGCCITIFDHANRL...
Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3. Catalytic Activity: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+) EC: 2.7.1.36 Subcellular Location: Cytoplasm Sequence Length: 350 Sequence Mass (Da): 3872...
A0A8B7PJS2
MAGGSIPSKRPRLINKVVFWSLCLLTLLLLTLESYGPEGIVPYDSADVRFKAPEIFFELSDEIVLSSDEALKYHYNRSSTDEVANTDKIDVSYIADFDGVKPVPFNRSLLKTILVWNNGYGLPAEGLADGDERELERMGCPQPNCVIMSRKKQAQPVQTYDAIIFHFRATTPDDLPLMRTPSQRWVFRESEPASYVFQYPHTYNGLFNWTFTYRTDSDIVMSPGRYIPLSKEEISKPKSALETRPLPKPKMAAWFVSNCNAHSGRDRIARQLEKFFDVDVYGRCGPLKCGREDSVSCRRMLEENYKFYLAFENSLCKDYA...
Pathway: Protein modification; protein glycosylation. EC: 2.4.1.- Subcellular Location: Golgi apparatus Sequence Length: 400 Sequence Mass (Da): 46654 Location Topology: Single-pass type II membrane protein
A0A448MMZ9
MTNKVIVALDYETEAEALTLVDQIDPSLCRLKVGKEMFTTLGTNFVKQLHQRDLMFSLI
Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. Function: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). EC: 4.1.1.23 Sequence Length: 59 Sequence Mass (Da): 6730
A0A3M7SCX9
MSLKRNPSRSIINFSAGPSSLPYEVLEIAQRELVAYGETGLSVMEMSHRSATFSKIINNAEQLVRELLNVPVNYSVLFLQGGGNGQFACVPLNLMNLKPKKSADYVLTGYWSERAANEAKKYGAVNLVFPKPEKYSRIPPVQEWNLDPEASYVFVCDNETINGIEFQEDITQALNGVPLVADCSSNLFSRQIDVSKYGLIFAGAQKNFGPSGVTLVIIRNDLIGHAAKECPSIFDYKIQAGNNSLYQTPPTFSIYMCGLVFEWLKKHGGMESIDKVNRMKADAVYEVIDNSNGFYYSPISPKDRSRVTIPFRLCVDGKPN...
Pathway: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. Function: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. EC: 2.6.1.52 Catalytic Activity: 2-oxoglutarate + ...
A0A2T5AIY0
MTVAVLGVGVDTVDLGAFAASLAEPGTRFAGAFSATERRQCRERAEARGAGPGTSRADGDRPGGSRSDGDRSGADRSRGATSSSSDQSTPMARHLAARWAVKEAVVKAWSAALYGTPPPISPDLLVWSEIETVCDAWGRPAVRLSGEVARQVAATVGEGTRWNVSLSHDGDSAVAFVVLEGTPTG
Function: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. Catalytic Activity: apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP] EC: 2.7.8.7 Subcellular Location: Cytoplasm Sequence Length: 185 Sequence Mass (Da): 19081
A0A6A0HBR6
MTETYYGRKILIADREQVEVGAGDLLQSADVQDVALLVVGDPLSATTHSDLMLRAQALGIPVQVLSNASVLTSAATTGLKLERLGEVVSIPYWEENWQPESFYDKICTNLKHGLHTLCLLDIKVKEQTVENIIKNRKLFEPPRFMRTHEAAKQLLAIIEKREQQDNSCTEGTLRRDTTCIACVRLGTERQKNLVMTLQESAEADLGEPLHSMVVCAPLSDAETRDAAALASWYQGATKPASSCAGRLHLIGMGLTISDITVKGVEILLKTNHVFLDKASRQILNVLLGSRSIREIFSDVFNPDELDRLDAAFDVNKPSVS...
Pathway: Protein modification; peptidyl-diphthamide biosynthesis. Function: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive ...
A0A938WLP8
MRQRLLSAIGMAAMVWIGASAQSDVTLTRNGDSYKMSNGTVSVSIGSNGRISEMTFRGGPNVLASNGVYFDYTADKNDNLNPTTSKIVRQTADYAEVVFSNTTADLRFEQGFIMRKGVNGVYVYVVANGTPTSSGVNLREARVCTRLNSSFVNGYVDEVMNGKIPTNAEMAVAEREENVVQDATYRMADGSIYTKYDWAQYVVRDSLHGLMNVNSGVWNIPCSHEWLNGGPMRQELTVHATSKSPITIQMLQGEHFGASSQRYEDGERKIYGPFLIYLNRGSQQQMIADAKRQASQQQAEWPFAWFDHELYPLDRSTVRG...
Catalytic Activity: Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end...
A0A9E3K221
ILDQWSMLQTVTGVGHSQYNGDVPINTTLTDGKYRMIDDSRGTGGTFGAMAITNANHGTSAGSVYVNDTNTWGDGKQYVAGGPTTNANGQTAAVNAMWGLMNTYDTLKNVFNWLSLDGHNTATYIAAHVNTAYDNAYYSDACRCMFIGDGASFNSLGSIDVIGHEMGHGVTAATSNLTYSGESGGLNESSSDINGEAVEAYARGGGKGDSIPLAGNDWVMGKEISKSGTPLRWMYRPSKDGSSPDAWSNSIKRLDVHYSSGPNNRMFYFLAQGSNADKASDYYSKYLVKTPAAMTGIGLDKAFRIWFKANTTKFTSSTNY...
Function: Extracellular zinc metalloprotease. EC: 3.4.24.- Subcellular Location: Secreted Sequence Length: 370 Sequence Mass (Da): 39355
A0A7X8SPM1
MKIGILGIGGIGGFIASKMLQSKDKDEIILITKERQKRAIISEGLTLLDGDKSEKVHVIDVVSTNDKIEKLDILFIAIKSYDLKESLKNIRSSISDKTLIIPLLNGISIKNIICDTLNLSERQVIDGCIYIISNKINDSTIRHVGGPGRIIIGGENQTALNTLQTVLEKYDLDIGYHKDIKEILWKKFLFVSPISAISTANGVTFGALQDDAYLMIQCQSLMEEVILIAKKLGINLSHEDIKNTIEMLKKFPYEAKSSFQLDIEKNQKNEKNILIDDVISLGEKLDLDVINYISINQQIMDRYLCVQ
Pathway: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2. Function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. EC: 1.1.1.169 Catalytic Activity: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH Sequence Length: 307 Sequen...
A0A7X7PBR7
YESRPNVTIDAAALCLKSGNATILRGGSEAFHSNQALGAIIQEGLAQAGLPAHAVQVVDTTDRAAVGEMVTMTEYIDVIVPRGGKGLIERLSREARVPLIKHLDGNCHLYIDKAADPEKAHAIAVNAKTYRYGICGAMETLLVHADVAATILPRIAATLAEKGVELRGCERARAILPTALPATEEDWRTEYLEPILAIRIVDDLDQAVEHIERYSSQHTESIVTEDLGAATRFQREVDSSSVYVNLPTCFADGFEYGLGAEIGISTNRLHARGPVGLEGLTTMKWVLTGEGQLRG
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. Function: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. ...
A0A0E9NDL6
MSFRIPSLIPRVSAFARPSHIARPLRSAVRHASTTPPPPPRFPNFPNGRPRMSAEQAKNNESFIYYTLSVFIGAFGVTYAVVPLYRLICQTTGFAGTPNTDASRFTPDKLIPVKDAKRIKVTFVGTVSDALQWTFTPQQREVHVLPGETALAFFTATNRSSEDIIGIATYNVNPQQAAQYFSKIQCFCFEEQRLLAGETIDMPIFFFIDPDFADDPLMKDIRTVTLSYTFFKARYDNGMLVPATN
Function: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. Subcellular Location: Mitochondrion inner membrane Sequence Length: 245 Sequence Mass (Da): 27493 Location Topology: Single-pass membrane protein
A0A931PRT3
MTTRGKFARVLLKLSGEALGGEQGFGRDAETFQKLAEQISRARKQSKTQIAIVVGGGNIIRGSDIKGMDRVVADQIGMLATVQNAMALAEALEERDIPTIIQSAVQVAYARPINPKKARAYLDRGYIVIFAGGTGNPFVTTDTAAAVRAREIHADVLLKATNVEGVFTADPKKDKSAKLLKRVSYDEAYARGLEVMDLASLALCKEHSLPVIVFDLYKPKNLEKAIAGEPVGTWVSA
Pathway: Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1. Function: Catalyzes the reversible phosphorylation of UMP to UDP. Catalytic Activity: ATP + UMP = ADP + UDP EC: 2.7.4.22 Subcellular Location: Cytoplasm Sequence Length: 237 Sequence Mass (Da): 25544
A0A931LPT8
MPEPKLTSPTVIRHLLGQYQIHLKKSLGQNFLADENILELIVTHAQLSRDDIVIEIGAGMGTLTHKLSNEAKHIVAVEIDSRLMPLLTENLRHCSNVTLVNQDFLDVNLADLVRAQRATSVKIVGNLPYKITSPILERLIAHRSFIESACVMVQREVADKLIAEPGNREASAVTIFAQAYANVEFLIKVSHHVFFPKPEVDSALLRLNFLKEPRFRAPEEIFFRVVRAAFNLRRKTLKKALAQSPLSGLPSEIILKALVEAQIDPERRGETLSIDEFDRVAMALSKDYLARSVFF
Function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Catalytic Activity: adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) +...
A0A834NA71
MVSNTFWMLLTVFLTIFANSGSALRCWECSSHMNAMCGDPMNSTDHQAMFHVKECGRGPYASSKPICRKMVKRDGGDRVVIRSCAIPNHDETDITDGPCSPLMTNGRDMVESCHICSTDLCNSASGLLTTQSLYIAGLILIGYRFFESNYNRVM
Function: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excita...
A0A1G0LR29
MLTIAAPEELRALVRDRAKAGARVGFVPTMGYLHEGHLALVAEAQRQADVVVMSIFVNPLQFGPTEDFASYPRDPGRDTQRAQQAGVDLLWMPAREQMYPASPAVTVAPGPVGAILEGAVRPGHFAGVLTVVSKLFAIVDPDVAVFGRKDAQQAALVRMMIRDLSLRVRLIVAPTVRAHDGLALSSRNIYLTTEQRAQALALPRALA
Pathway: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. EC: 6.3.2.1 Catalytic Activity: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+) Sequence Length: 207 Sequence Mass (Da): 22325
E3NTF6
MQWTTAYTESVHTYANTINTHEGGTHEEGFRGALTTLVNRYAREKNILREKDDNLSGDDVREGLTAVISVKLGEPQFEGQTKTKLGNTEAKAFVQKVVGDQLGDWFERNPGPAKDIIRKAIQAATARLAARKARETARRKGLLESGGMPGKLSDCTSKDPTISEIFIVEGDSAGGSAKTGRNPHTQAILPLRGKILNVEKARLDRALNNTEVQAMITAFGAGIGEEFDPEKARYHKIVLMADADVDGQHITTLLLTLLFRYMRPLIDLGYVYLAQPPLYRIKWANAEHEYVFSDAERDERLTAGSQAGRRLVKESGVQRY...
Function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. EC: 5.6.2.2 Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Sequence Length: 875 Sequence Mass (Da): 96813
A0A368A5L1
MSNKILIDASHKEETRVVVTRGNRIEEIDFESEHKKQLKGNIYLARITRVEPSLQAAFVEYGGNRHGFLAFSEIHPDYYQIPVTDRLALLEAEEQATKLDNENSDFIISEIEQKKLGKEKSRTRTVVSDVVSEYPNSDRNDTLAVDNTNSEDTVEFIGAEDALEEVPTQRVQRRNYRIQEVIKRRQILLVQIMKEERGNKGAALTTYLSLAGRYSVLMPNTARGGGISRKITSIADRKRLREILKDLSVPKGMGIILRTAGANRTKAEVKRDYEYLMRLWENVRNLTLNSIAPSLVYEESSLIKRSIRDLYNKDIDEILV...
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. EC: 3.1.26.12 Catalytic Activity: Endonucleolytic cleavage of single-stra...
A0A5C5V7N4
MSSMPPGPDHPAMSVAELTAQIKGLVEESFPSVWVTGEVSNFARPASGHCYFTLKDQHAQIRAVVWKGSAARLKFDLTDGLEIVCHGRLDLYAPRGSYQLVIDQAQPQGVGSLELALRQLKEKLTAEGLFDADRKRPLPSFPRRVGFVTSPTGAAIRDFLEVARRRWSGTQVLVIPTRVQGDGAAEEIAAAVQLANRVRPALDVLVVGRGGGSIEDLWCFNEAPVVRAVAASEIPTVSAVGHEIDVTLCDLAADVRAFTPSEAAERVIPSGDEFAGRVQTLHNRLHGTARRATQLRRQRLEALASRRPLARPYSLIQDHS...
Function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. Catalytic Activity: Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. EC: 3.1.11.6 Subcellular...
A0A1Q3RDA8
MNKIIIIAGPTAVGKTDLSIELAKTLSTEIISADSVQIYEKLDIGSAKPTLEEMAGIKHHLIDVVSPFDSFSVSDYAKAAKAAIKGLHDQGKIPVIVGGTGLYINALLYEMDFSESAADPEFREAMEKLARESGGEVLYQRLCDIDPDAAKRVHPNNLKRVIRALEINHITGRPMADFASDPKPTEDYDVLLFGLTRDREQLYDRINRRVHIIFEQGLLKEVDGLKNLGLDDSFQSMQGIGYKEVLTYYKGGMTYDELVDAIQQGSRHYAKRQFTWFKRYDNIKWLDLDELSTGDAISEILKYL
Function: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). EC: 2.5.1.75 Catalytic Activity: adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylall...
A0A5B8ELR4
MRVCIVGAGAIGGWIGTRLAASGAAEVSALARGATLGALRTHGWRLDQDGVRTTAPARVSESTADLGEQDVVVLTVKATALAAVVDRLEPLLGADTVVLPFLNGVPWWFTHGSDLGSLESVDPGGRVAAAVPFERVLGGVVHASCAAVEPGLVRHHLGNGLIVGEPGGGASARVDAVAGVLGAAGFDVTSSTDVRRDAWYKLWGNMTMNPVTALTGATGDRVLDDPLVRGLCSSAMLEAQRIGDLVGCPVRETPEDRHVVTSRLGALRTSMLLDVEAGRPLELDALIGAVHELGRRLDVPTPAVDAIFGLTRLFGRVHGL...
Pathway: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2. Function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. EC: 1.1.1.169 Catalytic Activity: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH Sequence Length: 326 Sequen...
J0TPJ1
MQEIGILENLQKSLALKEGMLSYEMLGKSLSYNPYLPRVIPQTKNCVFVTPDEVLEKLLKENTHTDCVIVNFKGLYEIGAPSVFDLEVLGLLRRHASSLIVHEDFFISHYQLLESLVQGSDGVILDEELLKEDLKGMVEFAWRLGLGVFVETHKPDYTHLKDLGVLGVLEISPHSYNQKKVVFLD
Pathway: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. EC: 4.1.1.48 Catalytic Activity: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O Sequence Length: 185 Sequence Mass (Da): 20973
A0A662EYK6
MSDAIHRPVMRTEAVRFLAPDRGGIYVDGTVGLGGHAAAILAAGPEVRLIGIDRDPQALRYAAARLAQFGDRVRLVHGNYRDLAEILAGLGIEAIDGFLLDLGLSSLQLDAPERGFSFRADGPLDMRMDPTQGRSAADLVNAASVEELARILRDYGEERFAGRIARAIVAARPIETTRALAEIVRRAIPRRFHERRIDPATRTFQALRIAVNDELRNLQDGLAAGFAALRPGGVIVVISFHSLEDRIVKRFFRKLATPRYESLAPGPPLPPQAEVLTKKPLRPSEEEIGENPRARSAKLRACRKL
Function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. Catalytic Activity: cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine EC: 2.1.1.199 Subcellular Location: Cytoplasm Sequence Length: 305 Seque...
A0A662ES82
MLLAVDIGNLQVGLGVYDGREWRGRFRIRAVPEKTADEYTVLLEGLFSRVGISPRKISGAIIASVVPPLTETFRKLCKGSFGITALVVGPGVRTGLELRVDHPSEVGPDLVADAVAAYERCRSACIAVDFATATTFTCVNEKGALVGVSIAPGLKVAAEALAQRAAKLPKIPLTPPRRAIGKNTQEALQSGVILGGVGMVEGLIRALSAELGGNARVIATGPYAEPIMGLTELIHEHDPWLTLEGLRIIAERNRYPPAPR
Cofactor: A monovalent cation. Ammonium or potassium. Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. EC: 2.7.1.33 Subcellular Location: Cytoplasm Catalytic Activity: (R)-pant...
A0A519PFS9
MNLNATLFAQFAVFFILALFTMKFVWPPLMKALDERAERIANGLAAADRGKADLAAAEKRVQAEMAGARDEVQKRIADAEKRAAQIIEAAKATAAEEAARIVAAANADAEQQ
Function: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria. Subcellular Location: Membrane Sequence Length: 112 Sequence Mass (Da): 12060 Location Topology: Single-pass membrane p...
A0A2X4NAW7
METEIINISKSNNKEEIYNKLITYYKDNKLIAIPTETVYGLSADAMSDEAVCKIYEAKGRPSDNPLIVHFYEMNQLNDIVDYQDERVDKLIENFWPGPMTLILNAKENNGISKKVSAGLSTLAVRMPSNKTARQILKETKVLLAAPSANTSGKPSPTKFEHVYHDLNGKIDVIIEDEQSDIGLESTVIDCTRTPLVIARPGEITKEDIEGILGLGSVKYNDEVMVDTQTPIAPGMKYRHYSPEAELLYYEDSLEKALEFLKTKNKKTGFITYKSNEHLFENLNISVKYLADNEKSVEQSNKNLYNILREFDEEKVEEIYI...
Function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalytic Activity: ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate EC: 2.7.7.87 Subcellular Location: Cytoplasm Sequence Len...
E3NV34
MFETKNVDSVQSMNSVLMNIKDFRQSMEMLTKYDWVPIPIAYPQVVFLAVRVYFIICLISRQYLLSAPPTEAQSIVRIMTILQFVFFVGWMKVAEALLNPLGEDDDDFECNWLIDRNMSTGIEIVDTLS
Function: Forms chloride channels. Subcellular Location: Cell membrane Sequence Length: 129 Sequence Mass (Da): 14924 Location Topology: Multi-pass membrane protein
A0A1Q3RGM3
MNEQMKITPRYLHGILSMPPSKSISHRAIICAALSQGTSRVENLVLSEDIKASIAAMIQFGAKIELDYNPISNRYTANIWGIKEAVDRPLTIDCRESGSTARFLIPFFQLTKSKVTFVGAEGLMKRPFGPYLRLFESQKLQYQSHSGALPITVSGSWQPGEYELVGNVSSQFITGLLFVLPLLEGDSQIRIKPPFESVDYVKLTISCLKKFGIDIIWKDDLTLWINGHQSYHASDYWVEGDYSQAAFWLVANSIGSHIVIEGLNTASEQGDKRIIEIIEQVTKQSESEGYLEIDVSQCPDLVPIIAVLCTVKPGLFKITG...
Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. Function: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-ph...
A0A3M0G889
MRVVITRVAEASVTVDGDLVSQLPRPGLLVLVGIARGDGPQDARAVAAKTWSLRILRDERSASDTNAPILVISQFTLHAATRRGRRPSWSAAASGDVSEPLVELFCRELEALGAEVGRGRFGAEMQVASVNDGPITILIDTQDWR
Function: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active si...
A0A1F3J3C0
MRISYDISLKQYNTFGIDVKAVCMAEIENADDLIALSESSLPEPLFCIGQGSNLLFTRDFNGTLIRMNNTGWGVISSQGDEVTIRANAGCIWDELVEQTLIKGYFGFENLSHIPGTVGSTPVQNIGAYGAEASQFIVSVHAFDRESQKFFDIENKDCDFGYRHSIFKSKPAWIVVSVDYRLKSVAATSTHYKAVETFLQENNLDGSDPMVVRKAVIAIRESKLPDYKQIGNAGSFFRNPVVEKKVFDQLHKKFPEMPFYAEADEKFKIPAAWLIEKSGWKGFQGFHAGVHDKQPLILINLGGASGQEIKMLAEEIQTSIK...
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine EC: 1.3.1.98 Subcellular Location: Cytoplasm Sequence Length: 334 Sequence Mass (Da): 37349