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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
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int64
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1,948
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C
C
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1
1,950
G
A
T
C
C
T
G
G
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A
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A
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C
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A
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A
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C
A
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A
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1
1,951
T
C
C
T
A
T
C
T
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C
A
C
A
G
A
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C
A
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C
A
C
C
C
T
G
A
G
G
G
A
T
T
A
C
A
T
C
C
C
C
A
G
G
A
T
C
C
T
G
G
G
A
C
C
C
G
A
G
G
C
C
T
T
C
G
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1
1,952
C
C
T
C
C
T
C
A
C
C
A
G
C
G
G
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T
G
G
A
T
C
G
T
G
G
C
A
T
G
G
C
C
G
A
A
G
C
G
G
A
A
G
G
C
G
G
C
T
G
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G
G
A
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A
C
A
C
G
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T
G
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T
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0.021526
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0.02544
1
1,953
C
A
T
G
A
G
G
T
G
T
G
C
A
A
G
G
G
A
A
G
G
A
A
C
T
G
G
C
A
G
A
C
C
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G
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G
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C
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T
G
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C
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C
C
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A
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0.033268
1
1,954
T
C
C
C
A
A
T
G
A
G
A
C
A
G
G
C
A
A
A
C
A
G
G
G
G
C
C
C
T
G
T
C
C
G
A
G
C
C
C
T
G
G
G
G
A
G
G
A
A
G
T
T
T
T
C
A
G
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A
A
G
C
C
T
T
0.021526
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1
1,955
A
G
A
G
G
C
G
T
G
A
G
C
T
G
G
A
G
A
A
G
C
A
C
T
C
C
C
T
G
T
C
T
C
G
G
G
T
C
A
T
C
T
G
T
G
A
C
A
A
C
A
C
T
G
G
C
C
T
C
A
C
C
A
G
G
T
0.029354
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1
1,956
G
T
G
G
C
A
G
G
G
G
G
G
G
T
G
G
G
C
A
C
C
G
T
C
T
G
C
A
C
A
C
T
C
G
T
T
C
A
C
A
T
C
T
G
C
C
A
G
A
C
A
C
A
C
A
A
G
G
C
C
A
C
A
C
A
T
0.02544
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0.04501
0.048924
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0.005871
0.007828
0.029354
1
1,957
C
C
A
G
G
A
G
C
G
G
G
G
C
C
C
G
C
T
G
C
A
T
G
T
T
C
T
T
C
G
T
G
C
G
C
T
C
C
A
G
C
C
C
T
G
T
G
T
G
C
G
G
C
A
G
C
G
G
C
A
T
G
A
C
T
T
0
0.017613
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0.041096
0.021526
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0.07045
0.056751
0.046967
0.009785
0
0.027397
1
1,958
T
A
A
C
A
A
C
C
T
G
C
A
G
C
A
C
C
C
C
A
T
G
T
G
G
G
G
C
G
C
C
T
C
G
C
T
G
A
C
C
G
C
C
T
T
C
G
A
G
C
G
C
C
T
G
C
T
G
A
A
A
T
C
C
G
T
0.007828
0.02544
0.017613
0.007828
0.039139
0.060665
0.037182
0.019569
0.015656
0.027397
0.04501
0
0.013699
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0.064579
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1
1,959
G
C
G
G
C
G
C
C
C
G
G
G
G
C
C
C
C
T
G
G
A
G
C
G
C
T
T
G
G
C
C
A
T
G
G
C
C
G
A
C
G
G
C
G
C
G
G
A
C
G
G
A
C
G
C
T
C
G
G
A
C
G
C
A
C
C
0
0.005871
0.009785
0.001957
0.015656
0.017613
0.033268
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0.013699
0.050881
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0
0.011742
0.021526
0.005871
0.041096
0.048924
0.046967
0.11546
0.105675
0.021526
0.109589
0
0.039139
0.011742
0.023483
0.046967
0.117417
0.043053
0
0
0.007828
1
1,960
T
T
G
G
G
A
G
C
T
G
G
T
G
G
C
C
A
G
C
A
T
A
C
T
T
C
G
A
A
T
G
C
T
T
T
T
G
T
C
C
G
C
C
A
G
G
G
G
G
C
A
G
C
C
A
G
A
C
A
G
A
C
T
G
T
C
0.113503
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0.072407
0.054795
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0.027397
0.021526
0.017613
0.054795
0.027397
1
1,961
C
C
C
C
A
C
T
C
C
G
G
G
C
T
G
C
A
C
G
G
G
G
C
G
C
G
G
G
C
A
T
G
T
C
A
A
C
A
G
C
A
A
C
A
G
G
A
A
C
T
C
C
C
A
C
C
G
A
A
G
G
T
A
A
G
A
0.033268
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0.054795
0.043053
0.048924
0.013699
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0.027397
1
1,962
T
T
C
T
G
G
A
G
G
G
A
C
C
C
T
A
T
C
T
T
T
G
T
G
C
G
G
G
C
A
T
C
C
G
G
A
C
A
G
G
C
T
G
C
G
G
T
G
A
T
G
T
G
G
G
T
A
C
A
G
C
C
C
A
G
T
0.04501
0.02544
0.046967
0.023483
0.04501
0.039139
0.011742
0.023483
0.048924
0.027397
0.033268
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0.027397
0.029354
0.033268
0.035225
0.02544
0.019569
0.029354
0.035225
1
1,963
T
A
G
A
C
T
T
C
C
T
G
G
G
C
G
G
C
A
G
A
C
A
A
A
C
C
A
A
A
G
A
G
C
G
G
A
A
A
T
T
C
A
T
G
T
A
A
G
T
T
A
T
C
A
G
A
T
A
C
G
T
T
T
A
A
T
0.11546
0.031311
0.039139
0.066536
0.04501
0.011742
0.007828
0.037182
0.060665
0.013699
0.021526
0.07045
0.021526
0.029354
0.035225
0.023483
0.029354
0.015656
0.015656
0.005871
0.001957
0.003914
0.033268
0.031311
0.052838
0.011742
0.017613
0.011742
0.015656
0.035225
0.048924
0.039139
1
1,964
A
G
G
A
G
G
A
G
A
A
G
C
G
C
T
A
C
G
C
G
G
A
C
G
C
C
C
A
G
C
T
G
T
C
C
T
G
C
C
A
G
G
G
C
C
G
C
G
G
G
G
G
C
A
C
G
C
T
G
A
G
C
A
T
G
C
0.005871
0.013699
0.031311
0.003914
0.029354
0.023483
0.031311
0.013699
0.019569
0.043053
0.066536
0.003914
0.011742
0.023483
0.027397
0.041096
0.060665
0.04501
0.060665
0.04501
0.021526
0.054795
0.005871
0.04501
0.015656
0.02544
0.056751
0.09589
0.035225
0.015656
0.005871
0.021526
1
1,965
G
A
A
G
G
C
G
C
C
C
T
C
C
T
T
C
T
C
C
A
G
G
T
C
G
T
T
G
A
T
G
C
C
G
A
T
G
A
A
G
A
C
A
C
G
G
G
C
C
A
G
G
C
C
G
G
C
T
T
G
C
G
C
C
A
T
0.007828
0.019569
0.033268
0.005871
0.04501
0.027397
0.027397
0.017613
0.019569
0.039139
0.056751
0.003914
0.011742
0.041096
0.031311
0.050881
0.052838
0.054795
0.050881
0.029354
0.019569
0.04501
0.005871
0.041096
0.019569
0.027397
0.046967
0.082192
0.031311
0.019569
0.005871
0.029354
1
1,966
G
G
A
C
C
A
T
A
C
C
A
T
G
A
A
C
G
C
G
T
T
C
A
T
C
G
G
C
C
G
C
T
T
G
A
T
G
T
G
G
C
C
C
G
A
C
G
C
C
G
T
C
T
T
G
C
A
C
C
A
G
T
C
T
G
G
0.015656
0.015656
0.035225
0.007828
0.013699
0.029354
0.021526
0.013699
0.027397
0.052838
0.037182
0.001957
0.02544
0.035225
0.033268
0.019569
0.043053
0.054795
0.064579
0.064579
0.027397
0.046967
0.003914
0.050881
0.02544
0.033268
0.04501
0.064579
0.062622
0.009785
0
0.017613
1
1,967
T
T
G
G
A
C
C
A
T
A
C
C
A
T
G
A
A
C
G
C
G
T
T
C
A
T
C
G
G
C
C
G
C
T
T
G
A
T
G
T
G
G
C
C
C
G
A
C
G
C
C
G
T
C
T
T
G
C
A
C
C
A
G
T
C
G
0.015656
0.015656
0.035225
0.007828
0.013699
0.029354
0.021526
0.013699
0.027397
0.054795
0.037182
0.001957
0.02544
0.035225
0.033268
0.019569
0.043053
0.054795
0.064579
0.062622
0.027397
0.046967
0.003914
0.050881
0.02544
0.033268
0.04501
0.064579
0.062622
0.009785
0
0.017613
1
1,968
T
C
A
A
G
C
G
G
C
C
G
A
T
G
A
A
C
G
C
G
T
T
C
A
T
G
G
T
A
T
G
G
T
C
C
A
A
G
A
T
C
G
A
A
C
G
C
A
G
G
A
A
G
A
T
C
A
T
G
G
A
G
C
A
G
C
0.013699
0.013699
0.031311
0.007828
0.013699
0.027397
0.021526
0.009785
0.035225
0.058708
0.031311
0.001957
0.02544
0.035225
0.027397
0.017613
0.04501
0.056751
0.064579
0.07045
0.02544
0.054795
0.003914
0.054795
0.02544
0.031311
0.039139
0.07045
0.058708
0.009785
0
0.017613
1
1,969
T
G
A
A
C
G
C
G
T
T
C
A
T
G
G
T
A
T
G
G
T
C
C
A
A
G
A
T
C
G
A
A
C
G
C
A
G
G
A
A
G
A
T
C
A
T
G
G
A
G
C
A
G
T
C
T
C
C
G
G
A
C
A
T
G
G
0.013699
0.013699
0.031311
0.007828
0.013699
0.02544
0.021526
0.009785
0.035225
0.058708
0.029354
0.001957
0.02544
0.035225
0.027397
0.015656
0.04501
0.052838
0.060665
0.076321
0.02544
0.060665
0.003914
0.052838
0.02544
0.031311
0.039139
0.076321
0.056751
0.009785
0
0.017613
1
1,970
C
T
C
G
C
T
G
T
C
C
T
T
C
A
G
C
A
T
T
T
T
C
C
A
G
C
G
C
T
T
G
C
C
C
A
G
C
C
T
C
T
T
G
G
A
G
A
T
C
T
C
G
G
C
G
T
T
G
T
G
C
A
T
G
T
G
0.015656
0.011742
0.037182
0.009785
0.013699
0.023483
0.017613
0.009785
0.037182
0.056751
0.027397
0.001957
0.02544
0.037182
0.033268
0.015656
0.039139
0.052838
0.046967
0.078278
0.023483
0.072407
0.003914
0.050881
0.027397
0.027397
0.041096
0.082192
0.052838
0.009785
0
0.017613
1
1,971
A
G
G
G
G
T
C
C
A
T
T
T
T
G
G
G
C
T
T
T
T
T
C
C
G
G
G
G
C
C
G
G
T
A
C
T
T
G
T
A
G
T
C
G
G
G
G
T
A
G
T
C
G
G
C
C
A
T
G
T
G
C
T
T
G
G
0.015656
0.009785
0.039139
0.005871
0.011742
0.017613
0.023483
0.015656
0.033268
0.048924
0.02544
0.001957
0.021526
0.029354
0.033268
0.011742
0.037182
0.048924
0.064579
0.084149
0.02544
0.09002
0.007828
0.039139
0.021526
0.033268
0.033268
0.099804
0.041096
0.013699
0
0.015656
1
1,972
C
T
G
G
T
G
T
A
C
T
G
A
T
A
A
G
A
G
G
A
A
T
G
G
T
G
T
C
A
T
T
A
T
A
G
C
G
G
G
A
T
A
C
T
G
T
G
T
A
G
A
A
G
G
G
A
C
A
C
T
T
G
C
C
A
C
0.062622
0.019569
0.043053
0.052838
0.050881
0.021526
0.007828
0.029354
0.04501
0.031311
0.033268
0.037182
0.035225
0.046967
0.031311
0.037182
0.041096
0.029354
0.015656
0.007828
0
0.003914
0.029354
0.02544
0.041096
0.021526
0.027397
0.019569
0.029354
0.029354
0.04501
0.048924
1
1,973
G
G
C
C
T
T
G
T
T
C
T
G
G
T
T
T
T
T
T
G
T
C
T
G
C
T
A
A
A
A
A
T
C
C
C
A
T
A
A
C
C
T
G
T
A
A
A
A
A
A
A
A
A
A
T
A
C
T
T
G
A
A
G
A
A
T
0.103718
0.046967
0.04501
0.050881
0.041096
0.02544
0.001957
0.039139
0.041096
0.017613
0.029354
0.046967
0.023483
0.043053
0.039139
0.021526
0.037182
0.027397
0.011742
0.001957
0.003914
0.003914
0.027397
0.017613
0.048924
0.017613
0.029354
0.015656
0.017613
0.021526
0.056751
0.04501
1
1,974
C
T
G
T
C
T
T
A
A
T
A
G
C
C
T
T
T
C
T
A
G
T
C
A
T
C
T
C
T
T
T
A
C
G
G
G
C
T
T
C
C
A
C
A
G
A
C
A
G
C
T
T
A
A
A
A
A
A
A
A
G
A
A
T
A
T
0.099804
0.029354
0.066536
0.052838
0.02544
0.019569
0.003914
0.041096
0.058708
0.033268
0.023483
0.054795
0.02544
0.031311
0.031311
0.027397
0.033268
0.021526
0.009785
0.001957
0.001957
0
0.031311
0.02544
0.058708
0.011742
0.029354
0.011742
0.015656
0.021526
0.056751
0.04501
1
1,975
T
T
A
T
G
A
A
G
C
C
A
G
G
T
G
T
G
A
T
G
T
A
A
C
T
C
T
A
A
C
C
C
T
G
A
A
A
G
A
A
C
T
C
C
A
G
C
A
G
A
T
G
A
A
A
G
A
C
A
T
T
G
A
A
A
G
0.105675
0.043053
0.041096
0.066536
0.043053
0.02544
0
0.046967
0.043053
0.013699
0.017613
0.068493
0.021526
0.039139
0.035225
0.023483
0.033268
0.027397
0.003914
0.001957
0.003914
0.001957
0.02544
0.019569
0.04501
0.017613
0.02544
0.001957
0.019569
0.031311
0.07045
0.037182
1
1,976
A
C
T
C
A
A
A
G
C
C
G
G
C
C
C
T
G
A
C
T
C
G
G
G
G
G
C
C
G
C
C
A
T
G
T
T
C
G
C
C
G
A
G
G
A
C
T
C
A
G
G
C
A
G
C
G
G
A
G
G
A
G
T
G
T
G
0.019569
0.02544
0.037182
0.013699
0.035225
0.027397
0.019569
0.035225
0.035225
0.035225
0.048924
0.015656
0.015656
0.021526
0.035225
0.035225
0.037182
0.039139
0.041096
0.043053
0.017613
0.02544
0.027397
0.052838
0.027397
0.037182
0.023483
0.056751
0.046967
0.019569
0.015656
0.033268
1
1,977
G
G
A
C
A
T
C
T
G
G
A
A
G
A
A
G
T
T
T
G
A
G
C
T
G
C
T
G
C
C
C
A
C
G
C
C
C
C
C
G
C
T
G
T
C
G
C
C
C
A
G
C
C
G
T
G
G
C
T
T
C
G
C
G
G
T
0.009785
0.017613
0.031311
0.001957
0.011742
0.02544
0.027397
0.017613
0.027397
0.068493
0.023483
0.001957
0.013699
0.021526
0.011742
0.027397
0.04501
0.037182
0.09589
0.080235
0.043053
0.048924
0.005871
0.054795
0.035225
0.029354
0.037182
0.074364
0.043053
0.007828
0.003914
0.019569
1
1,978
G
C
T
G
G
C
G
C
T
C
C
A
G
G
A
T
G
T
T
G
T
G
G
T
T
T
C
T
G
C
G
A
C
G
C
T
C
A
C
T
G
T
C
C
T
C
C
G
A
G
T
C
A
G
A
G
T
T
T
C
G
G
G
G
G
T
0.043053
0.019569
0.041096
0.011742
0.019569
0.023483
0.029354
0.027397
0.033268
0.056751
0.041096
0.005871
0.017613
0.019569
0.033268
0.041096
0.046967
0.046967
0.048924
0.02544
0.019569
0.035225
0.011742
0.058708
0.031311
0.033268
0.039139
0.037182
0.052838
0.005871
0.007828
0.035225
1
1,979
G
T
C
G
C
A
G
A
A
A
C
C
A
C
A
A
C
A
T
C
C
T
G
G
A
G
C
G
C
C
A
G
C
G
C
C
G
C
A
A
C
G
A
C
C
T
T
C
G
G
T
C
C
A
G
C
T
T
T
C
T
C
A
C
G
A
0.048924
0.019569
0.041096
0.011742
0.019569
0.021526
0.02544
0.033268
0.033268
0.054795
0.041096
0.005871
0.015656
0.017613
0.035225
0.041096
0.048924
0.046967
0.04501
0.02544
0.019569
0.031311
0.011742
0.060665
0.029354
0.035225
0.041096
0.037182
0.052838
0.005871
0.007828
0.035225
1
1,980
G
C
G
T
G
A
G
A
A
A
G
C
T
G
G
A
C
C
G
A
A
G
G
T
C
G
T
T
G
C
G
G
C
G
C
T
G
G
C
G
C
T
C
C
A
G
G
A
T
G
T
T
G
T
G
G
T
T
T
C
T
G
C
G
A
T
0.048924
0.019569
0.041096
0.011742
0.021526
0.021526
0.02544
0.033268
0.033268
0.054795
0.039139
0.005871
0.015656
0.017613
0.035225
0.041096
0.048924
0.046967
0.04501
0.02544
0.019569
0.031311
0.011742
0.060665
0.029354
0.035225
0.041096
0.037182
0.052838
0.005871
0.007828
0.035225
1
1,981
T
G
A
G
C
G
T
G
A
G
A
A
A
G
C
T
G
G
A
C
C
G
A
A
G
G
T
C
G
T
T
G
C
G
G
C
G
C
T
G
G
C
G
C
T
C
C
A
G
G
A
T
G
T
T
G
T
G
G
T
T
T
C
T
G
T
0.050881
0.019569
0.041096
0.013699
0.021526
0.021526
0.02544
0.033268
0.033268
0.054795
0.039139
0.005871
0.015656
0.019569
0.035225
0.041096
0.046967
0.04501
0.043053
0.02544
0.019569
0.031311
0.011742
0.060665
0.029354
0.035225
0.041096
0.037182
0.052838
0.005871
0.007828
0.035225
1
1,982
G
C
A
A
G
G
A
C
A
C
C
G
T
G
T
T
T
G
C
A
T
A
C
A
C
T
G
C
A
C
A
T
C
C
A
G
A
A
T
T
G
A
T
A
C
T
C
A
G
T
G
A
T
T
G
G
G
C
T
T
C
C
T
G
T
A
0.117417
0.037182
0.041096
0.062622
0.048924
0.007828
0.005871
0.041096
0.023483
0.019569
0.019569
0.093933
0.015656
0.048924
0.031311
0.02544
0.031311
0.021526
0.013699
0.003914
0
0.001957
0.015656
0.015656
0.041096
0.007828
0.031311
0.017613
0.019569
0.033268
0.068493
0.037182
1
1,983
T
A
G
A
C
T
G
T
T
A
A
C
A
C
T
C
A
T
T
T
C
T
T
G
T
T
T
T
T
A
C
C
T
C
A
G
G
A
T
C
C
A
A
G
T
T
T
C
T
G
A
A
A
A
C
A
T
A
C
A
T
T
C
T
T
C
0.105675
0.041096
0.04501
0.060665
0.037182
0.009785
0.009785
0.037182
0.060665
0.013699
0.023483
0.050881
0.031311
0.033268
0.043053
0.011742
0.031311
0.02544
0.009785
0.007828
0.005871
0
0.029354
0.029354
0.052838
0.019569
0.023483
0.013699
0.033268
0.021526
0.048924
0.033268
1
1,984
T
C
G
T
G
A
A
T
C
T
G
G
C
A
C
C
A
T
T
C
A
G
A
G
A
T
A
C
A
G
T
C
T
A
C
C
T
A
A
T
G
T
T
G
G
T
T
T
G
A
T
T
C
A
A
A
A
A
T
A
T
T
C
C
C
C
0.088063
0.033268
0.033268
0.09002
0.04501
0.021526
0.009785
0.035225
0.039139
0.013699
0.019569
0.062622
0.029354
0.048924
0.037182
0.015656
0.02544
0.023483
0.009785
0
0.005871
0.003914
0.035225
0.013699
0.037182
0.019569
0.015656
0.009785
0.011742
0.041096
0.082192
0.043053
1
1,985
T
T
G
A
C
A
C
T
G
G
C
A
T
G
T
A
C
G
T
A
G
T
A
G
G
C
A
T
C
C
A
G
T
G
G
A
A
C
C
A
C
A
T
G
G
G
C
A
G
C
G
T
G
T
T
A
G
C
T
G
T
G
G
C
A
C
0.103718
0.037182
0.041096
0.037182
0.046967
0.013699
0.019569
0.035225
0.037182
0.017613
0.035225
0.02544
0.033268
0.041096
0.029354
0.037182
0.033268
0.029354
0.017613
0.013699
0.001957
0.007828
0.027397
0.023483
0.039139
0.011742
0.02544
0.033268
0.031311
0.029354
0.046967
0.037182
1
1,986
T
A
C
T
T
T
G
G
T
C
A
T
T
C
T
C
A
T
G
T
C
T
C
A
T
T
A
T
T
T
G
G
C
A
T
C
T
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C
C
A
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T
A
T
C
A
A
A
G
C
A
A
A
C
A
G
C
A
A
G
G
C
A
A
T
0.121331
0.021526
0.023483
0.066536
0.029354
0.015656
0.011742
0.033268
0.039139
0.031311
0.027397
0.035225
0.017613
0.029354
0.039139
0.027397
0.04501
0.039139
0.013699
0.007828
0.009785
0.005871
0.027397
0.035225
0.037182
0.015656
0.035225
0.037182
0.021526
0.02544
0.037182
0.037182
1
1,987
C
T
T
A
A
A
A
G
A
A
A
T
T
G
A
A
T
G
A
C
T
C
A
C
C
A
C
T
A
T
G
A
C
C
T
T
C
A
A
G
A
G
T
C
T
G
A
T
T
C
A
T
A
G
A
A
A
G
G
T
T
A
C
T
G
T
0.097847
0.035225
0.037182
0.064579
0.039139
0.023483
0.003914
0.037182
0.037182
0.015656
0.023483
0.066536
0.023483
0.060665
0.037182
0.013699
0.02544
0.023483
0.027397
0
0.003914
0
0.031311
0.017613
0.035225
0.013699
0.033268
0.017613
0.005871
0.041096
0.064579
0.043053
1
1,988
A
A
G
G
A
T
A
C
A
C
C
T
T
G
A
A
T
G
C
C
G
A
C
A
A
G
A
A
A
A
C
G
T
G
T
T
C
A
G
G
T
G
A
G
G
C
C
T
G
T
G
T
A
G
G
G
G
G
C
C
G
T
G
A
C
A
0.076321
0.027397
0.046967
0.023483
0.041096
0.02544
0.013699
0.043053
0.031311
0.035225
0.043053
0.02544
0.023483
0.02544
0.031311
0.04501
0.050881
0.037182
0.027397
0.007828
0.005871
0.003914
0.023483
0.031311
0.037182
0.02544
0.027397
0.027397
0.035225
0.02544
0.031311
0.04501
1
1,989
T
C
G
G
G
C
C
C
A
A
G
C
A
T
C
T
G
G
T
A
T
T
G
A
G
C
T
C
T
A
T
G
C
T
G
T
G
G
G
C
G
T
G
G
A
C
C
G
G
G
C
A
G
A
C
A
T
G
G
C
G
T
C
C
C
A
0.037182
0.023483
0.035225
0.031311
0.037182
0.031311
0.011742
0.021526
0.046967
0.029354
0.050881
0.02544
0.023483
0.043053
0.029354
0.033268
0.04501
0.060665
0.039139
0.009785
0.011742
0.005871
0.027397
0.041096
0.039139
0.029354
0.019569
0.050881
0.039139
0.015656
0.021526
0.033268
1
1,990
C
T
C
T
T
C
T
A
A
C
A
T
C
C
C
T
A
A
G
G
T
G
G
C
C
A
T
C
A
T
T
G
T
T
A
C
A
G
A
T
G
G
G
A
G
G
C
C
C
C
A
G
G
A
C
C
A
G
G
T
G
A
A
T
G
A
0.013699
0.023483
0.031311
0.019569
0.039139
0.031311
0.013699
0.02544
0.041096
0.035225
0.050881
0.017613
0.027397
0.043053
0.02544
0.043053
0.048924
0.062622
0.041096
0.013699
0.021526
0.009785
0.033268
0.039139
0.035225
0.033268
0.02544
0.058708
0.037182
0.009785
0.013699
0.035225
1
1,991
C
T
G
G
A
G
T
T
G
G
A
A
C
T
C
G
A
T
C
T
T
C
A
C
A
G
T
G
C
T
A
G
C
A
T
A
G
T
T
C
A
C
C
A
C
T
G
C
C
A
C
C
C
G
C
G
T
G
T
C
G
G
C
T
G
G
0.019569
0.021526
0.033268
0.029354
0.037182
0.031311
0.011742
0.027397
0.035225
0.031311
0.052838
0.009785
0.033268
0.031311
0.035225
0.04501
0.056751
0.058708
0.037182
0.015656
0.023483
0.007828
0.021526
0.035225
0.033268
0.029354
0.039139
0.058708
0.037182
0.011742
0.015656
0.033268
1
1,992
G
A
C
A
G
T
G
A
A
A
T
A
T
T
A
T
G
A
A
C
T
T
G
A
A
G
A
A
A
A
G
A
T
A
G
T
C
A
G
T
C
T
G
A
T
C
A
A
G
A
A
C
C
T
G
T
T
A
G
T
T
G
C
T
C
C
0.056751
0.029354
0.066536
0.068493
0.019569
0.007828
0.005871
0.037182
0.056751
0.02544
0.023483
0.064579
0.046967
0.027397
0.04501
0.015656
0.041096
0.029354
0.007828
0.001957
0.009785
0.001957
0.011742
0.023483
0.066536
0.013699
0.02544
0.017613
0.029354
0.013699
0.054795
0.054795
1
1,993
G
T
T
A
C
A
G
C
A
G
A
T
C
C
A
T
C
A
A
T
A
C
A
T
T
A
T
G
G
C
C
C
T
T
C
G
T
G
A
A
G
A
A
T
A
T
T
T
T
G
A
T
C
C
A
A
G
T
A
T
A
G
T
T
G
C
0.056751
0.035225
0.07045
0.066536
0.02544
0.007828
0.003914
0.037182
0.058708
0.02544
0.023483
0.064579
0.048924
0.031311
0.046967
0.011742
0.037182
0.023483
0.007828
0.001957
0.005871
0
0.015656
0.023483
0.068493
0.013699
0.019569
0.009785
0.031311
0.013699
0.054795
0.058708
1
1,994
A
A
C
A
A
G
A
G
C
T
G
A
C
A
T
T
T
G
C
C
A
T
G
G
A
G
A
G
A
G
T
T
C
C
A
G
G
G
T
G
G
C
T
T
T
G
C
T
T
G
T
A
T
G
T
T
C
T
C
C
G
T
T
G
G
T
0.054795
0.02544
0.060665
0.037182
0.02544
0.027397
0.007828
0.031311
0.04501
0.035225
0.04501
0.023483
0.019569
0.031311
0.041096
0.033268
0.04501
0.052838
0.019569
0.009785
0.007828
0.001957
0.017613
0.033268
0.068493
0.021526
0.031311
0.029354
0.050881
0.011742
0.013699
0.041096
1
1,995
T
T
T
T
G
G
A
A
G
T
G
C
C
C
T
G
C
A
G
C
T
T
C
A
C
T
G
A
A
G
A
C
C
G
T
G
T
G
C
T
C
T
T
G
G
A
A
T
T
C
A
A
G
T
A
A
G
T
G
T
T
G
G
C
C
A
0.052838
0.029354
0.064579
0.039139
0.02544
0.027397
0.007828
0.041096
0.043053
0.043053
0.033268
0.023483
0.013699
0.035225
0.050881
0.027397
0.033268
0.048924
0.015656
0.009785
0.005871
0.003914
0.019569
0.043053
0.062622
0.017613
0.027397
0.019569
0.04501
0.027397
0.019569
0.043053
1
1,996
A
A
T
T
T
G
T
T
G
C
T
C
A
G
A
G
A
C
A
G
A
G
C
T
G
T
G
G
C
T
A
A
C
T
T
C
A
A
T
C
C
C
C
T
T
T
T
T
C
T
T
G
T
C
A
A
T
C
T
T
G
T
G
G
T
G
0.066536
0.023483
0.050881
0.07045
0.041096
0.023483
0.001957
0.035225
0.04501
0.031311
0.023483
0.029354
0.02544
0.039139
0.058708
0.029354
0.035225
0.041096
0.013699
0.001957
0.001957
0.001957
0.017613
0.031311
0.052838
0.019569
0.027397
0.013699
0.029354
0.029354
0.033268
0.054795
1
1,997
G
A
G
G
T
T
A
A
T
G
G
A
G
T
G
A
A
C
A
T
C
T
T
G
G
T
T
T
T
T
A
T
C
A
T
A
C
T
T
T
A
C
A
A
A
A
G
C
A
A
C
A
A
T
T
G
T
A
A
A
T
T
C
T
T
A
0.064579
0.035225
0.039139
0.062622
0.037182
0.015656
0.009785
0.039139
0.048924
0.033268
0.019569
0.027397
0.029354
0.033268
0.062622
0.021526
0.037182
0.041096
0.021526
0.001957
0.005871
0.001957
0.015656
0.048924
0.035225
0.019569
0.027397
0.019569
0.027397
0.027397
0.039139
0.050881
1
1,998
C
T
G
G
G
G
A
T
G
A
A
G
A
T
T
A
C
A
C
C
T
A
T
T
T
G
A
T
T
C
T
G
C
G
G
G
T
A
A
T
C
T
C
A
G
T
C
T
T
T
T
A
T
A
T
G
A
C
A
T
A
C
A
T
C
T
0.07045
0.02544
0.048924
0.052838
0.029354
0.027397
0
0.029354
0.046967
0.035225
0.033268
0.031311
0.033268
0.043053
0.035225
0.015656
0.054795
0.04501
0.02544
0.003914
0
0.003914
0.017613
0.02544
0.050881
0.02544
0.027397
0.013699
0.041096
0.019569
0.041096
0.046967
1
1,999
G
G
T
G
A
G
T
G
T
G
C
A
A
G
G
C
C
G
C
G
G
T
G
G
C
C
G
C
G
T
G
A
C
A
A
G
C
C
T
G
C
G
C
T
A
C
C
A
G
T
G
C
G
C
C
C
G
C
C
G
G
C
C
A
G
T
0.021526
0.017613
0.035225
0.003914
0.023483
0.050881
0.015656
0.019569
0.019569
0.031311
0.048924
0.003914
0.02544
0.017613
0.029354
0.050881
0.035225
0.050881
0.056751
0.064579
0.023483
0.066536
0.007828
0.041096
0.017613
0.023483
0.039139
0.066536
0.04501
0.017613
0.009785
0.019569
1
2,000
C
C
G
C
C
A
C
C
T
C
T
T
C
G
C
T
C
C
G
C
T
G
A
A
G
G
A
G
T
A
T
T
T
T
G
C
G
T
G
T
G
T
G
T
A
A
G
G
G
A
C
A
T
G
G
G
G
G
C
A
A
A
C
T
G
C
0.080235
0.035225
0.031311
0.019569
0.04501
0.033268
0.009785
0.02544
0.035225
0.029354
0.043053
0.019569
0.011742
0.027397
0.033268
0.037182
0.050881
0.04501
0.041096
0.027397
0.009785
0.019569
0.007828
0.043053
0.031311
0.029354
0.033268
0.039139
0.043053
0.013699
0.021526
0.027397
1
2,001
G
T
C
A
T
G
G
A
G
C
G
T
G
C
C
A
G
T
C
A
T
C
C
G
C
C
A
C
C
T
C
T
T
C
G
C
T
C
C
G
C
T
G
A
A
G
G
A
G
T
A
T
T
T
T
G
C
G
T
G
T
G
T
G
T
C
0.068493
0.033268
0.031311
0.017613
0.04501
0.035225
0.011742
0.02544
0.037182
0.029354
0.043053
0.017613
0.011742
0.027397
0.033268
0.041096
0.052838
0.046967
0.043053
0.027397
0.009785
0.021526
0.005871
0.046967
0.031311
0.029354
0.033268
0.039139
0.043053
0.013699
0.017613
0.029354
1
2,002
A
T
G
A
C
C
G
G
C
C
C
A
G
C
A
G
T
C
T
C
T
G
C
C
T
C
G
C
C
A
A
G
C
G
G
C
T
C
A
T
G
T
T
G
G
A
G
A
C
G
T
C
A
G
T
A
T
A
G
T
G
G
A
C
T
A
0.060665
0.037182
0.029354
0.013699
0.04501
0.037182
0.011742
0.029354
0.041096
0.029354
0.039139
0.019569
0.011742
0.021526
0.029354
0.04501
0.056751
0.046967
0.041096
0.033268
0.009785
0.019569
0.007828
0.046967
0.029354
0.029354
0.035225
0.041096
0.041096
0.013699
0.021526
0.02544
1
2,003
C
A
G
T
C
C
A
C
T
A
T
A
C
T
G
A
C
G
T
C
T
C
C
A
A
C
A
T
G
A
G
C
C
G
C
T
T
G
G
C
G
A
G
G
C
A
G
A
G
A
C
T
G
C
T
G
G
G
C
C
G
G
T
C
A
T
0.060665
0.037182
0.029354
0.013699
0.04501
0.039139
0.011742
0.029354
0.041096
0.029354
0.039139
0.019569
0.011742
0.021526
0.029354
0.04501
0.056751
0.046967
0.041096
0.033268
0.009785
0.019569
0.007828
0.04501
0.029354
0.029354
0.035225
0.041096
0.041096
0.013699
0.021526
0.02544
1
2,004
C
A
G
T
C
C
A
C
T
A
T
A
C
T
G
A
C
G
T
C
T
C
C
A
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A
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A
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T
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G
A
G
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A
G
A
G
A
C
T
G
C
T
G
G
G
C
C
G
G
T
C
A
G
0.060665
0.037182
0.029354
0.013699
0.04501
0.039139
0.011742
0.029354
0.041096
0.029354
0.039139
0.019569
0.011742
0.021526
0.029354
0.04501
0.056751
0.046967
0.041096
0.033268
0.009785
0.019569
0.007828
0.04501
0.029354
0.029354
0.035225
0.041096
0.041096
0.013699
0.021526
0.02544
1
2,005
A
A
A
C
C
A
A
G
G
T
T
G
C
T
G
G
C
T
A
T
A
C
C
T
C
G
A
G
A
A
A
T
C
G
C
G
A
G
A
T
G
T
C
C
C
T
C
T
T
G
T
C
A
C
T
A
A
C
G
C
C
C
A
T
G
T
0.017613
0.015656
0.046967
0.011742
0.02544
0.035225
0.005871
0.019569
0.052838
0.043053
0.054795
0.009785
0.021526
0.031311
0.027397
0.035225
0.052838
0.056751
0.058708
0.023483
0.017613
0.015656
0.021526
0.052838
0.039139
0.027397
0.037182
0.056751
0.043053
0.007828
0.007828
0.027397
1
2,006
T
G
C
A
T
G
A
T
G
C
G
C
G
G
C
C
C
A
A
G
G
A
G
G
G
A
G
A
T
G
A
T
C
G
C
C
C
C
T
T
C
T
T
C
T
G
G
C
T
C
T
T
T
G
A
G
A
A
T
G
T
G
G
T
G
T
0.017613
0.011742
0.048924
0.011742
0.02544
0.027397
0.005871
0.015656
0.048924
0.050881
0.060665
0.015656
0.02544
0.033268
0.02544
0.029354
0.056751
0.054795
0.056751
0.019569
0.015656
0.017613
0.021526
0.048924
0.041096
0.02544
0.039139
0.056751
0.050881
0.009785
0.005871
0.02544
1
2,007
C
T
C
C
C
T
C
C
T
T
G
G
G
C
C
G
C
G
C
A
T
C
A
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G
C
A
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G
A
G
G
C
G
G
T
A
G
A
A
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T
C
A
A
A
G
A
A
G
A
G
C
C
G
G
C
C
A
G
T
G
C
C
C
T
0.015656
0.011742
0.04501
0.011742
0.02544
0.031311
0.009785
0.015656
0.046967
0.050881
0.056751
0.013699
0.02544
0.035225
0.029354
0.029354
0.054795
0.054795
0.056751
0.021526
0.019569
0.019569
0.019569
0.048924
0.035225
0.027397
0.041096
0.056751
0.04501
0.013699
0.003914
0.027397
1
2,008
C
C
T
A
C
C
G
T
A
G
A
G
G
C
C
C
T
T
G
C
G
A
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C
A
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G
G
T
T
G
A
C
G
A
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G
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G
A
G
G
T
C
A
T
T
G
C
A
G
G
G
A
C
T
G
C
C
C
C
C
A
A
T
0.019569
0.015656
0.041096
0.013699
0.027397
0.031311
0.017613
0.017613
0.052838
0.039139
0.062622
0.013699
0.029354
0.021526
0.029354
0.029354
0.062622
0.048924
0.056751
0.021526
0.017613
0.005871
0.017613
0.048924
0.035225
0.039139
0.043053
0.04501
0.056751
0.009785
0.005871
0.023483
1
2,009
A
C
G
G
T
G
C
T
G
T
C
T
G
C
T
G
G
C
T
G
G
T
G
C
A
G
G
G
C
T
C
C
T
G
G
T
G
C
T
G
A
A
G
G
A
C
T
T
G
G
G
C
A
T
T
C
A
G
G
T
G
G
A
C
C
C
0.027397
0.011742
0.037182
0.009785
0.031311
0.033268
0.017613
0.019569
0.031311
0.039139
0.062622
0.009785
0.023483
0.043053
0.023483
0.039139
0.066536
0.052838
0.04501
0.021526
0.011742
0.011742
0.009785
0.041096
0.027397
0.035225
0.056751
0.052838
0.052838
0.015656
0.007828
0.031311
1
2,010
G
C
C
G
C
A
G
C
A
G
C
C
C
G
T
A
G
G
T
A
C
C
C
T
T
G
T
G
C
C
C
G
C
A
C
A
T
G
T
A
G
C
A
G
T
T
C
C
A
G
G
G
G
T
C
T
T
C
C
T
T
A
A
T
G
A
0.007828
0.009785
0.02544
0.009785
0.031311
0.046967
0.005871
0.011742
0.031311
0.056751
0.064579
0.001957
0.003914
0.015656
0.019569
0.048924
0.066536
0.072407
0.088063
0.033268
0.009785
0.033268
0.015656
0.056751
0.017613
0.027397
0.035225
0.07045
0.052838
0.009785
0.007828
0.011742
1
2,011
G
C
C
C
G
T
A
G
G
T
A
C
C
C
T
T
G
T
G
C
C
C
G
C
A
C
A
T
G
T
A
G
C
A
G
T
T
C
C
A
G
G
G
G
T
C
T
T
C
C
T
T
A
A
T
G
G
C
T
G
C
C
T
G
G
T
0.007828
0.007828
0.027397
0.009785
0.027397
0.046967
0.005871
0.011742
0.033268
0.058708
0.064579
0.001957
0.003914
0.015656
0.017613
0.046967
0.064579
0.072407
0.088063
0.033268
0.009785
0.033268
0.017613
0.058708
0.017613
0.027397
0.033268
0.07045
0.054795
0.009785
0.009785
0.011742
1
2,012
C
A
C
C
A
T
C
T
G
C
T
G
T
G
G
G
G
G
C
C
G
T
G
A
G
G
T
G
C
T
C
A
T
G
T
G
C
G
G
A
A
A
C
A
A
C
A
A
C
T
G
C
T
G
C
A
G
G
T
G
A
G
G
C
T
A
0.013699
0.013699
0.027397
0.001957
0.029354
0.052838
0.019569
0.019569
0.037182
0.04501
0.07045
0
0.005871
0.015656
0.011742
0.052838
0.072407
0.066536
0.07045
0.027397
0.007828
0.015656
0.019569
0.050881
0.02544
0.041096
0.035225
0.052838
0.058708
0.013699
0.005871
0.019569
1
2,013
C
C
A
G
G
G
T
A
A
C
A
T
T
G
A
G
G
C
T
C
C
C
A
C
A
G
G
A
G
A
T
G
C
A
G
A
T
G
T
C
T
G
G
A
A
A
G
C
A
G
A
G
G
G
A
G
G
G
G
A
T
G
G
G
G
G
0.031311
0.017613
0.031311
0.005871
0.043053
0.043053
0.011742
0.017613
0.043053
0.035225
0.054795
0
0.017613
0.031311
0.021526
0.058708
0.060665
0.056751
0.066536
0.029354
0.009785
0.007828
0.003914
0.054795
0.033268
0.027397
0.039139
0.050881
0.046967
0.013699
0.001957
0.033268
1
2,014
G
C
C
G
A
G
C
A
G
C
T
G
A
A
G
G
C
A
C
C
C
G
C
T
G
G
G
T
C
A
T
G
T
G
G
T
T
C
G
G
A
G
A
C
G
G
C
A
A
A
T
T
C
T
C
A
G
T
G
G
T
A
A
G
T
C
0.017613
0.021526
0.023483
0.021526
0.023483
0.043053
0.007828
0.019569
0.029354
0.048924
0.048924
0.003914
0.021526
0.023483
0.02544
0.046967
0.07045
0.082192
0.09589
0.023483
0.005871
0.005871
0.019569
0.033268
0.031311
0.015656
0.035225
0.066536
0.04501
0.009785
0.009785
0.023483
1
2,015
A
C
T
G
C
G
G
G
G
C
T
T
C
T
C
C
T
G
G
T
G
G
C
C
A
G
G
C
C
G
C
A
T
T
G
T
G
T
C
T
T
G
G
T
G
G
A
T
G
A
C
G
G
G
C
C
G
G
A
G
C
C
G
A
G
A
0.017613
0.017613
0.02544
0.023483
0.023483
0.04501
0.009785
0.015656
0.035225
0.041096
0.046967
0.001957
0.021526
0.023483
0.029354
0.04501
0.066536
0.076321
0.103718
0.029354
0.009785
0.005871
0.007828
0.039139
0.029354
0.021526
0.037182
0.064579
0.043053
0.009785
0.007828
0.02544
1
2,016
G
C
C
T
G
G
C
C
A
C
C
A
G
G
A
G
A
A
G
C
C
C
C
G
C
A
G
T
T
T
C
C
C
C
C
A
C
A
C
C
A
G
C
T
C
C
C
C
A
A
T
G
C
C
A
A
A
G
C
C
C
C
G
G
C
A
0.017613
0.015656
0.021526
0.019569
0.021526
0.039139
0.011742
0.015656
0.041096
0.043053
0.04501
0
0.021526
0.02544
0.027397
0.043053
0.064579
0.076321
0.103718
0.033268
0.011742
0.009785
0.003914
0.054795
0.02544
0.021526
0.035225
0.068493
0.04501
0.007828
0.003914
0.02544
1
2,017
G
T
C
T
T
T
G
G
A
A
G
T
T
T
T
C
T
C
G
G
T
C
G
T
G
A
T
A
A
T
C
T
C
C
A
G
C
A
G
C
T
G
C
A
T
C
T
T
G
T
C
C
A
C
G
G
G
A
G
A
G
A
A
G
T
G
0.056751
0.031311
0.04501
0.029354
0.029354
0.037182
0.005871
0.031311
0.046967
0.039139
0.039139
0.035225
0.02544
0.031311
0.039139
0.029354
0.050881
0.048924
0.031311
0.009785
0.005871
0.001957
0.021526
0.039139
0.041096
0.027397
0.035225
0.013699
0.046967
0.015656
0.02544
0.033268
1
2,018
A
A
T
G
A
C
C
A
A
A
G
A
A
T
C
A
A
A
G
G
C
C
T
T
G
A
T
G
G
G
A
C
T
C
T
A
C
C
A
T
G
G
T
C
A
G
G
T
C
C
T
G
T
G
C
A
A
G
A
A
G
A
A
T
A
C
0.064579
0.029354
0.068493
0.029354
0.039139
0.017613
0.003914
0.04501
0.066536
0.029354
0.041096
0.013699
0.023483
0.027397
0.035225
0.02544
0.050881
0.023483
0.029354
0.001957
0
0.001957
0.021526
0.041096
0.058708
0.02544
0.029354
0.017613
0.033268
0.02544
0.033268
0.046967
1
2,019
T
G
C
C
A
T
G
A
C
T
A
T
T
C
C
A
T
T
T
G
T
C
A
G
G
C
A
A
C
A
G
G
T
T
T
A
C
A
A
A
A
A
A
G
T
G
G
A
A
G
A
A
A
A
A
G
T
G
C
G
A
A
A
G
C
A
0.086106
0.021526
0.056751
0.060665
0.033268
0.015656
0.001957
0.039139
0.039139
0.031311
0.035225
0.076321
0.019569
0.041096
0.029354
0.023483
0.027397
0.021526
0.013699
0
0.001957
0.003914
0.037182
0.023483
0.041096
0.013699
0.033268
0.017613
0.023483
0.031311
0.066536
0.033268
1
2,020
A
A
G
A
T
T
T
T
T
A
A
A
G
G
G
G
T
A
A
G
T
C
A
A
G
A
T
A
G
T
C
A
T
T
C
T
G
G
A
A
T
C
T
A
A
A
A
A
G
A
G
A
A
G
A
A
C
A
A
A
A
G
T
A
T
C
0.093933
0.035225
0.033268
0.074364
0.039139
0.019569
0.001957
0.029354
0.048924
0.02544
0.021526
0.054795
0.043053
0.043053
0.037182
0.011742
0.035225
0.033268
0.015656
0
0.003914
0.001957
0.035225
0.021526
0.035225
0.011742
0.019569
0.011742
0.023483
0.031311
0.072407
0.035225
1
2,021
T
C
A
T
T
T
C
A
C
C
T
G
G
T
A
C
T
T
T
G
A
A
G
G
G
T
A
C
C
A
C
A
T
C
A
G
A
A
A
G
G
A
G
T
C
C
T
T
C
A
T
C
C
T
G
T
G
C
C
T
T
C
T
T
G
C
0.074364
0.043053
0.039139
0.041096
0.043053
0.027397
0
0.037182
0.041096
0.027397
0.037182
0.035225
0.027397
0.037182
0.029354
0.033268
0.046967
0.035225
0.011742
0.013699
0.005871
0.007828
0.021526
0.035225
0.04501
0.013699
0.033268
0.017613
0.039139
0.017613
0.046967
0.035225
1
2,022
T
G
C
A
A
A
C
C
A
A
T
C
A
G
A
A
T
C
C
A
T
G
G
C
T
T
T
A
A
A
A
T
T
T
G
C
C
A
A
A
A
T
C
T
G
A
C
C
C
T
G
G
A
A
G
A
G
A
A
A
A
T
A
A
T
C
0.107632
0.039139
0.054795
0.068493
0.02544
0.031311
0.009785
0.023483
0.054795
0.015656
0.029354
0.041096
0.02544
0.029354
0.035225
0.021526
0.027397
0.037182
0.013699
0.003914
0.007828
0.005871
0.021526
0.019569
0.062622
0.011742
0.013699
0.019569
0.019569
0.017613
0.068493
0.037182
1
2,023
C
T
T
C
C
A
G
G
G
T
C
A
G
A
T
T
T
T
G
G
C
A
A
A
T
T
T
T
A
A
A
G
C
C
A
T
G
G
A
T
T
C
T
G
A
T
T
G
G
T
T
T
G
C
A
G
A
A
A
A
C
T
A
C
A
T
0.109589
0.039139
0.054795
0.07045
0.02544
0.031311
0.009785
0.023483
0.054795
0.015656
0.029354
0.041096
0.02544
0.029354
0.035225
0.021526
0.027397
0.037182
0.013699
0.003914
0.007828
0.005871
0.021526
0.017613
0.064579
0.011742
0.013699
0.019569
0.019569
0.017613
0.064579
0.037182
1
2,024
C
T
A
A
G
C
C
A
T
A
C
T
G
G
C
C
T
C
C
T
T
C
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C
C
G
T
A
A
T
C
T
G
T
T
G
G
C
A
G
C
A
G
C
C
A
T
G
A
C
C
A
A
C
C
T
G
C
A
G
C
C
A
T
0.097847
0.027397
0.04501
0.037182
0.031311
0.023483
0.017613
0.039139
0.048924
0.029354
0.031311
0.027397
0.02544
0.023483
0.037182
0.021526
0.048924
0.048924
0.037182
0.001957
0.001957
0.001957
0.019569
0.033268
0.02544
0.027397
0.023483
0.023483
0.035225
0.035225
0.046967
0.02544
1
2,025
A
T
T
A
C
G
G
A
A
A
G
A
A
G
G
A
G
G
C
C
A
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A
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C
T
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A
G
T
G
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C
T
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C
G
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C
A
G
C
T
G
G
A
G
G
G
C
A
G
G
T
A
C
G
T
T
G
0.086106
0.029354
0.039139
0.035225
0.031311
0.029354
0.017613
0.035225
0.046967
0.031311
0.033268
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0.02544
0.02544
0.035225
0.02544
0.052838
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0.001957
0.001957
0.019569
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0.02544
0.027397
0.02544
0.023483
0.037182
0.031311
0.041096
0.027397
1
2,026
G
C
T
C
C
C
C
T
A
A
G
G
G
A
G
T
G
C
T
A
G
A
A
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G
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C
T
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T
G
C
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C
G
T
C
C
A
C
A
C
C
A
T
C
T
G
C
A
A
C
A
G
0.086106
0.043053
0.043053
0.029354
0.056751
0.023483
0.005871
0.037182
0.033268
0.027397
0.035225
0.035225
0.033268
0.031311
0.037182
0.041096
0.043053
0.048924
0.02544
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0.001957
0.001957
0.027397
0.019569
0.039139
0.015656
0.021526
0.019569
0.04501
0.023483
0.039139
0.027397
1
2,027
G
C
T
C
A
T
G
T
T
G
G
G
G
C
T
C
T
T
C
C
T
C
T
A
C
A
G
C
C
T
C
C
C
T
G
G
C
T
A
C
A
T
G
G
T
C
A
A
A
A
A
G
C
T
C
C
T
T
G
G
G
G
C
A
T
G
0.015656
0.007828
0.039139
0.001957
0.017613
0.019569
0.007828
0.021526
0.027397
0.062622
0.058708
0
0.015656
0.033268
0.027397
0.023483
0.07045
0.066536
0.091977
0.033268
0.007828
0.021526
0.003914
0.056751
0.021526
0.023483
0.039139
0.09002
0.050881
0.011742
0
0.031311
1
2,028
G
G
T
T
G
A
G
G
A
A
C
C
A
G
A
C
G
A
A
G
G
C
C
G
T
G
T
C
G
G
G
C
C
G
G
C
T
G
G
G
A
A
G
T
G
G
A
A
G
A
G
A
G
G
A
G
C
C
G
G
T
C
A
G
C
T
0.031311
0.013699
0.04501
0.007828
0.015656
0.02544
0.005871
0.02544
0.031311
0.062622
0.048924
0.001957
0.021526
0.039139
0.031311
0.021526
0.056751
0.064579
0.078278
0.027397
0.009785
0.011742
0.015656
0.050881
0.02544
0.017613
0.043053
0.066536
0.048924
0.019569
0.009785
0.02544
1
2,029
G
G
T
T
C
A
G
G
A
A
C
C
A
G
A
T
G
A
A
G
C
T
C
G
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G
T
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G
G
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C
C
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G
C
T
G
G
A
G
T
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T
G
A
A
G
G
G
T
A
G
A
G
A
G
C
G
C
A
G
A
G
G
T
0.015656
0.013699
0.041096
0.005871
0.031311
0.023483
0.007828
0.021526
0.050881
0.056751
0.074364
0.009785
0.013699
0.013699
0.021526
0.037182
0.068493
0.056751
0.050881
0.011742
0.015656
0.019569
0.02544
0.068493
0.037182
0.017613
0.037182
0.066536
0.052838
0.013699
0.001957
0.017613
1
2,030
T
G
T
T
C
T
C
C
T
G
G
G
A
C
G
A
G
A
C
C
G
A
G
T
A
C
A
A
G
A
T
C
C
C
C
G
C
G
C
G
G
C
T
C
A
C
C
C
T
G
C
A
G
A
T
C
T
G
G
G
A
T
G
C
G
G
0
0.019569
0.031311
0.001957
0.027397
0.039139
0.013699
0.02544
0.04501
0.02544
0.064579
0
0.027397
0.017613
0.019569
0.033268
0.07045
0.060665
0.088063
0.029354
0.015656
0.031311
0.011742
0.046967
0.031311
0.041096
0.031311
0.052838
0.064579
0.009785
0.001957
0.021526
1
2,031
C
C
A
G
T
G
C
C
T
C
A
G
G
G
C
C
A
A
C
A
G
C
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C
C
A
C
A
T
G
C
T
C
G
T
C
T
G
T
G
G
G
C
T
T
C
C
T
C
T
G
A
C
C
T
G
T
G
G
G
T
G
C
C
G
T
0.013699
0.015656
0.043053
0.003914
0.033268
0.037182
0.005871
0.021526
0.041096
0.048924
0.060665
0.003914
0.009785
0.02544
0.031311
0.043053
0.074364
0.060665
0.064579
0.019569
0.009785
0.019569
0.011742
0.043053
0.027397
0.035225
0.052838
0.066536
0.037182
0.007828
0.003914
0.027397
1
2,032
C
C
C
G
C
C
T
C
T
G
C
A
A
A
G
A
C
G
G
C
A
A
A
G
T
G
G
A
C
G
G
C
C
C
C
C
A
C
T
T
T
G
G
G
C
C
C
C
C
T
G
G
G
A
G
A
G
T
G
A
A
G
G
T
G
A
0.011742
0.017613
0.023483
0.007828
0.02544
0.029354
0.013699
0.023483
0.039139
0.043053
0.068493
0.003914
0.019569
0.019569
0.019569
0.039139
0.080235
0.068493
0.097847
0.015656
0.003914
0.009785
0.017613
0.050881
0.019569
0.031311
0.02544
0.082192
0.041096
0.003914
0.009785
0.037182
1
2,033
T
G
A
G
A
C
C
C
T
G
T
G
T
C
C
C
A
C
C
T
G
G
G
A
C
C
A
G
A
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G
C
T
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G
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G
T
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C
G
A
C
A
A
C
C
T
G
G
A
G
C
T
C
T
A
T
G
G
T
G
A
A
G
C
0.011742
0.011742
0.027397
0.021526
0.039139
0.04501
0.005871
0.011742
0.031311
0.050881
0.056751
0.015656
0.023483
0.037182
0.027397
0.050881
0.072407
0.068493
0.078278
0.005871
0.007828
0.007828
0.009785
0.041096
0.027397
0.035225
0.039139
0.039139
0.046967
0.003914
0.007828
0.041096
1
2,034
C
C
C
C
A
C
A
G
A
G
A
A
G
C
A
G
G
C
G
T
T
C
C
A
G
C
T
C
C
G
A
G
C
G
C
A
C
A
T
G
T
A
C
C
A
G
G
C
C
C
G
C
A
G
C
C
T
C
T
T
T
G
C
C
G
A
0.009785
0.011742
0.029354
0.001957
0.033268
0.029354
0.005871
0.019569
0.029354
0.054795
0.084149
0.001957
0.007828
0.011742
0.015656
0.046967
0.093933
0.052838
0.072407
0.023483
0.007828
0.021526
0.001957
0.062622
0.02544
0.021526
0.043053
0.088063
0.043053
0.009785
0.001957
0.037182
1
2,035
C
T
C
A
T
C
C
A
G
C
A
G
C
G
T
G
T
A
G
T
T
A
C
G
T
G
T
G
G
A
G
C
C
G
T
A
C
A
T
G
T
T
C
A
C
C
C
A
G
G
C
T
G
G
G
C
C
C
A
G
T
G
T
G
G
T
0.013699
0.013699
0.021526
0.005871
0.037182
0.033268
0.015656
0.017613
0.027397
0.058708
0.066536
0.001957
0.011742
0.019569
0.007828
0.058708
0.084149
0.066536
0.09589
0.013699
0.005871
0.011742
0.005871
0.058708
0.029354
0.019569
0.033268
0.062622
0.052838
0.011742
0.003914
0.033268
1
2,036
G
C
C
C
A
C
C
A
C
G
G
C
A
A
C
G
T
C
A
C
A
C
T
T
C
A
C
G
T
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G
C
C
C
T
T
C
A
G
C
C
C
C
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A
G
G
A
G
A
T
G
T
C
A
T
C
G
G
G
G
T
C
A
G
G
0.005871
0.009785
0.02544
0.007828
0.02544
0.041096
0.017613
0.019569
0.043053
0.04501
0.056751
0.001957
0.015656
0.021526
0.027397
0.050881
0.066536
0.058708
0.111546
0.019569
0.011742
0.005871
0.013699
0.060665
0.015656
0.039139
0.043053
0.058708
0.035225
0.003914
0
0.041096
1
2,037
G
G
G
C
G
G
G
A
C
G
A
T
G
A
A
G
C
G
G
C
A
G
A
A
C
G
T
G
C
G
C
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C
G
C
T
G
G
C
G
C
T
C
A
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C
G
T
G
T
G
C
A
C
C
T
T
C
A
C
C
T
A
C
C
A
0
0.003914
0.017613
0
0.007828
0.02544
0.021526
0.005871
0.007828
0.072407
0.031311
0
0.011742
0.011742
0.005871
0.035225
0.048924
0.027397
0.080235
0.11546
0.027397
0.136986
0.007828
0.043053
0.015656
0.013699
0.04501
0.123288
0.027397
0.007828
0
0.021526
1
2,038
C
T
T
G
C
C
G
C
C
A
T
C
C
G
T
G
C
T
G
G
G
T
G
C
C
G
C
G
T
G
C
C
C
G
T
A
G
C
C
T
G
G
G
G
G
A
A
A
G
T
G
G
G
A
A
A
G
A
G
G
A
G
A
A
A
T
0.019569
0.013699
0.04501
0.005871
0.033268
0.031311
0.027397
0.011742
0.033268
0.041096
0.046967
0.007828
0.017613
0.043053
0.021526
0.056751
0.039139
0.050881
0.060665
0.029354
0.013699
0.054795
0.013699
0.033268
0.039139
0.015656
0.054795
0.056751
0.039139
0.017613
0.003914
0.021526
1
2,039
T
G
G
C
G
C
G
G
T
G
C
A
G
C
A
G
G
T
A
C
C
T
C
A
C
C
A
A
G
G
T
G
T
T
G
A
T
G
C
G
C
T
C
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C
C
C
A
G
G
C
T
C
T
G
G
A
A
C
A
T
G
A
C
G
C
0.015656
0.013699
0.039139
0.001957
0.021526
0.035225
0.029354
0.015656
0.031311
0.043053
0.043053
0.001957
0.019569
0.039139
0.015656
0.054795
0.048924
0.058708
0.060665
0.033268
0.019569
0.060665
0.013699
0.031311
0.037182
0.017613
0.058708
0.064579
0.035225
0.017613
0.001957
0.019569
1
2,040
C
G
A
A
G
C
C
G
A
T
G
G
T
G
G
T
G
A
G
G
G
T
G
A
T
G
A
A
G
C
A
G
T
A
G
T
A
G
T
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G
G
C
C
T
G
G
A
A
G
A
A
G
G
T
C
C
A
G
T
G
C
T
C
G
C
0
0.015656
0.035225
0
0.015656
0.035225
0.043053
0.013699
0.023483
0.048924
0.04501
0
0.017613
0.04501
0.011742
0.04501
0.046967
0.041096
0.029354
0.043053
0.033268
0.091977
0.013699
0.035225
0.035225
0.023483
0.058708
0.072407
0.021526
0.023483
0.001957
0.033268
1
2,041
G
G
C
C
T
G
G
T
C
C
T
T
C
T
G
C
A
G
C
G
C
C
A
C
G
T
A
G
T
C
G
C
C
G
A
A
G
C
C
G
A
T
G
G
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G
G
T
G
A
G
G
G
T
G
A
T
G
A
A
G
C
A
G
T
G
0
0.011742
0.033268
0
0.015656
0.035225
0.043053
0.015656
0.019569
0.046967
0.04501
0
0.019569
0.043053
0.011742
0.050881
0.043053
0.041096
0.027397
0.046967
0.033268
0.09589
0.013699
0.037182
0.031311
0.02544
0.054795
0.072407
0.02544
0.023483
0.001957
0.035225
1
2,042
G
G
G
C
C
T
G
G
T
C
C
T
T
C
T
G
C
A
G
C
G
C
C
A
C
G
T
A
G
T
C
G
C
C
G
A
A
G
C
C
G
A
T
G
G
T
G
G
T
G
A
G
G
G
T
G
A
T
G
A
A
G
C
A
G
T
0
0.011742
0.033268
0
0.015656
0.035225
0.04501
0.015656
0.019569
0.046967
0.04501
0
0.019569
0.041096
0.011742
0.050881
0.043053
0.041096
0.027397
0.046967
0.033268
0.09589
0.013699
0.037182
0.031311
0.02544
0.054795
0.072407
0.02544
0.023483
0.001957
0.035225
1
2,043
G
C
C
C
G
T
A
A
G
G
A
T
G
T
A
G
A
C
G
A
A
G
C
T
G
A
A
G
G
C
C
A
C
G
T
A
C
T
G
C
G
G
C
T
G
C
G
T
C
T
G
C
A
G
G
G
C
C
T
G
G
T
C
C
T
G
0
0.009785
0.035225
0
0.011742
0.035225
0.046967
0.017613
0.019569
0.04501
0.043053
0
0.015656
0.035225
0.009785
0.050881
0.043053
0.035225
0.02544
0.060665
0.029354
0.101761
0.015656
0.031311
0.031311
0.02544
0.062622
0.080235
0.02544
0.02544
0.001957
0.029354
1
2,044
A
G
A
T
C
C
A
G
C
A
C
C
A
G
C
T
G
C
A
G
C
T
C
C
T
G
G
A
C
A
C
C
C
G
C
G
T
C
T
C
C
A
C
C
C
A
C
G
A
C
C
A
G
G
A
G
C
T
G
G
G
T
C
A
C
T
0.001957
0.011742
0.015656
0.001957
0.013699
0.029354
0.013699
0.009785
0.021526
0.088063
0.07045
0
0.011742
0.017613
0.015656
0.029354
0.109589
0.050881
0.062622
0.039139
0.007828
0.033268
0.003914
0.062622
0.013699
0.02544
0.080235
0.072407
0.058708
0
0
0.027397
1
2,045
G
A
G
A
A
C
G
G
T
G
C
A
G
G
A
G
T
T
G
G
A
C
G
C
G
T
T
G
C
C
T
C
C
G
C
G
C
T
G
C
C
A
T
C
T
C
T
G
G
G
A
C
A
A
A
C
A
C
C
T
G
C
A
A
A
T
0.015656
0.017613
0.029354
0.013699
0.033268
0.019569
0.013699
0.015656
0.035225
0.054795
0.062622
0.005871
0.017613
0.029354
0.027397
0.02544
0.072407
0.054795
0.080235
0.023483
0.005871
0.019569
0.013699
0.052838
0.02544
0.023483
0.046967
0.064579
0.056751
0.015656
0.007828
0.019569
1
2,046
G
A
G
C
A
G
G
G
A
G
A
G
A
A
C
G
G
T
G
C
A
G
G
A
G
T
T
G
G
A
C
G
C
G
T
T
G
C
C
T
C
C
G
C
G
C
T
G
C
C
A
T
C
T
C
T
G
G
G
A
C
A
A
A
C
T
0.013699
0.015656
0.027397
0.013699
0.033268
0.019569
0.015656
0.013699
0.037182
0.054795
0.062622
0.005871
0.017613
0.029354
0.027397
0.027397
0.07045
0.056751
0.080235
0.023483
0.005871
0.021526
0.013699
0.054795
0.021526
0.023483
0.046967
0.068493
0.054795
0.015656
0.007828
0.019569
1