drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00013 | DB00814 | 1,255 | 1,171 | [
"DDInter1905",
"DDInter1143"
] | Urokinase | Meloxicam | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Moderate | 1 | [
[
[
1255,
24,
1171
]
],
[
[
1255,
24,
1027
],
[
1027,
40,
1171
]
],
[
[
1255,
25,
936
],
[
936,
63,
1171
]
],
[
[
1255,
24,
477
],
[
477,
... | [
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
]
],
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piroxicam"
],
[
... | Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam and Piroxicam (Compound) resembles Meloxicam (Compound)
Urokinase may lead to a major life threatening interaction when taken with Cangrelor and Cangrelor may cause a moderate interaction that could exacerbate diseases w... |
DB00620 | DB01023 | 175 | 409 | [
"DDInter1855",
"DDInter716"
] | Triamcinolone | Felodipine | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Moderate | 1 | [
[
[
175,
24,
409
]
],
[
[
175,
63,
376
],
[
376,
40,
409
]
],
[
[
175,
24,
1081
],
[
1081,
40,
409
]
],
[
[
175,
63,
1428
],
[
1428,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Felodipine (Compound)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Felodipine (Co... |
DB00774 | DB01246 | 1,577 | 820 | [
"DDInter889",
"DDInter45"
] | Hydroflumethiazide | Alimemazine | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1577,
24,
820
]
],
[
[
1577,
24,
104
],
[
104,
40,
820
]
],
[
[
1577,
24,
401
],
[
401,
24,
820
]
],
[
[
1577,
21,
28741
],
[
28741,
... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazi... | Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a modera... |
DB00087 | DB11767 | 599 | 1,583 | [
"DDInter41",
"DDInter1643"
] | Alemtuzumab | Sarilumab | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
599,
24,
1583
]
],
[
[
599,
24,
1186
],
[
1186,
24,
1583
]
],
[
[
599,
24,
287
],
[
287,
63,
1583
]
],
[
[
599,
63,
305
],
[
305,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 dichloride and Radium Ra 223 dichloride may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when tak... |
DB00414 | DB00446 | 590 | 597 | [
"DDInter16",
"DDInter351"
] | Acetohexamide | Chloramphenicol | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Moderate | 1 | [
[
[
590,
24,
597
]
],
[
[
590,
63,
1101
],
[
1101,
23,
597
]
],
[
[
590,
24,
318
],
[
318,
62,
597
]
],
[
[
590,
24,
932
],
[
932,
6... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram... |
DB00414 | DB00621 | 590 | 1,026 | [
"DDInter16",
"DDInter1357"
] | Acetohexamide | Oxandrolone | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | A synthetic hormone with anabolic and androgenic properties. | Moderate | 1 | [
[
[
590,
24,
1026
]
],
[
[
590,
24,
1546
],
[
1546,
1,
1026
]
],
[
[
590,
63,
989
],
[
989,
1,
1026
]
],
[
[
590,
24,
1019
],
[
1019,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxandrolone"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Oxandrolone (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Progesterone and Progesterone (Compound) resem... |
DB00163 | DB00432 | 1,461 | 1,083 | [
"DDInter1943",
"DDInter1868"
] | Vitamin E | Trifluridine | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine] . It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activit... | Moderate | 1 | [
[
[
1461,
24,
1083
]
],
[
[
1461,
24,
141
],
[
141,
1,
1083
]
],
[
[
1461,
23,
270
],
[
270,
63,
1083
]
],
[
[
1461,
62,
58
],
[
58,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluridine"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Floxuridine"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine (Compound) resembles Trifluridine (Compound)
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that cou... |
DB00393 | DB00902 | 854 | 104 | [
"DDInter1295",
"DDInter1168"
] | Nimodipine | Methdilazine | Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction ... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
854,
24,
104
]
],
[
[
854,
24,
820
],
[
820,
1,
104
]
],
[
[
854,
24,
401
],
[
401,
63,
104
]
],
[
[
854,
1,
1081
],
[
1081,
24,... | [
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
[... | Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine (Compound) resembles Methdilazine (Compound)
Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction th... |
DB00398 | DB01601 | 79 | 833 | [
"DDInter1702",
"DDInter1089"
] | Sorafenib | Lopinavir | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to ... | Moderate | 1 | [
[
[
79,
24,
833
]
],
[
[
79,
25,
1327
],
[
1327,
40,
833
]
],
[
[
79,
6,
4973
],
[
4973,
45,
833
]
],
[
[
79,
7,
7374
],
[
7374,
46,... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lopinavir"
]
],
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
],
[
"Saquinavir",
... | Sorafenib may lead to a major life threatening interaction when taken with Saquinavir and Saquinavir (Compound) resembles Lopinavir (Compound)
Sorafenib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lopinavir (Compound)
Sorafenib (Compound) upregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Lopina... |
DB04855 | DB11057 | 540 | 720 | [
"DDInter602",
"DDInter1223"
] | Dronedarone | Mineral oil | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
540,
24,
720
]
],
[
[
540,
25,
927
],
[
927,
63,
720
]
],
[
[
540,
64,
1151
],
[
1151,
24,
720
]
],
[
[
540,
25,
1069
],
[
1069,
... | [
[
[
"Dronedarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encora... | Dronedarone may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Dronedarone may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib may cause a moderate i... |
DB00414 | DB01390 | 590 | 1,117 | [
"DDInter16",
"DDInter1683"
] | Acetohexamide | Sodium bicarbonate | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Moderate | 1 | [
[
[
590,
24,
1117
]
],
[
[
590,
24,
1220
],
[
1220,
23,
1117
]
],
[
[
590,
24,
972
],
[
972,
63,
1117
]
],
[
[
590,
63,
362
],
[
362,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbonate
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Cho... |
DB01050 | DB01124 | 848 | 1,411 | [
"DDInter900",
"DDInter1828"
] | Ibuprofen | Tolbutamide | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
848,
24,
1411
]
],
[
[
848,
24,
959
],
[
959,
40,
1411
]
],
[
[
848,
62,
824
],
[
824,
24,
1411
]
],
[
[
848,
63,
245
],
[
245,
... | [
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Ibuprofen may cause a minor interaction that can limit clinical effects when taken with Probenecid and Probenecid may cause a moderate interaction that could exac... |
DB01087 | DB06288 | 1,520 | 607 | [
"DDInter1520",
"DDInter77"
] | Primaquine | Amisulpride | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Major | 2 | [
[
[
1520,
25,
607
]
],
[
[
1520,
21,
28722
],
[
28722,
60,
607
]
],
[
[
1520,
62,
112
],
[
112,
23,
607
]
],
[
[
1520,
63,
1559
],
[
1559,... | [
[
[
"Primaquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amisulpride"
]
],
[
[
"Primaquine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} (Compound)... | Primaquine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Amisulpride (Compound)
Primaquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Amisulprid... |
DB00307 | DB11581 | 1,101 | 1,456 | [
"DDInter202",
"DDInter1926"
] | Bexarotene | Venetoclax | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
1101,
24,
1456
]
],
[
[
1101,
24,
1135
],
[
1135,
23,
1456
]
],
[
[
1101,
23,
536
],
[
536,
24,
1456
]
],
[
[
1101,
24,
259
],
[
259,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Secobarbital and Secobarbit... |
DB00848 | DB10795 | 281 | 221 | [
"DDInter1044",
"DDInter1486"
] | Levamisole | Poliovirus type 1 antigen (formaldehyde inactivated) | Levamisole is an antihelminthic drug that was commonly used for the treatment of parasitic, viral, and bacterial infections. It was manufactured by _Janssen_ and first used in 1969 as an agent to treat worm infestations Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer. Prior to this,... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
281,
24,
221
]
],
[
[
281,
64,
581
],
[
581,
24,
221
]
],
[
[
281,
63,
599
],
[
599,
24,
221
]
],
[
[
281,
24,
1531
],
[
1531,
2... | [
[
[
"Levamisole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Levamisole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"... | Levamisole may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Levamisole may cause a moderate interaction that could exacerbate diseases when taken... |
DB00039 | DB00848 | 1,253 | 281 | [
"DDInter1380",
"DDInter1044"
] | Palifermin | Levamisole | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Levamisole is an antihelminthic drug that was commonly used for the treatment of parasitic, viral, and bacterial infections. It was manufactured by _Janssen_ and first used in 1969 as an agent to treat worm infestations Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer. Prior to this,... | Moderate | 1 | [
[
[
1253,
24,
281
]
],
[
[
1253,
24,
599
],
[
599,
24,
281
]
],
[
[
1253,
24,
4
],
[
4,
63,
281
]
],
[
[
1253,
24,
1064
],
[
1064,
2... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamisole"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Levamisole
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuc... |
DB00367 | DB09038 | 566 | 1,450 | [
"DDInter1061",
"DDInter636"
] | Levonorgestrel | Empagliflozin | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
566,
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],
[
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[
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[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin lispro"
... | Levonorgestrel may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro and Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Levonorgestrel may cause a moderate interaction that could exacerbate diseases when taken with Lo... |
DB00668 | DB01367 | 874 | 1,163 | [
"DDInter652",
"DDInter1572"
] | Epinephrine | Rasagiline | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
874,
24,
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]
],
[
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[
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[
590,
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[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Epinephrine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)... | Epinephrine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Rasagiline (Compound)
Epinephrine (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Rasagiline (Compound)
Epinephrine may cause a moderate interaction that could exacerbate diseases when tak... |
DB00006 | DB00574 | 942 | 121 | [
"DDInter217",
"DDInter717"
] | Bivalirudin | Fenfluramine | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Moderate | 1 | [
[
[
942,
24,
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[
[
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[
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[
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[
291,
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],
[
[
942,
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958
],
[
958,
63,... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eptifibatide"
],
... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Eptifibatide and Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Bivalirudin may lead to a major life threatening interaction when taken with Argatroban and Argatroban ma... |
DB00341 | DB01105 | 1,242 | 222 | [
"DDInter343",
"DDInter1665"
] | Cetirizine | Sibutramine | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1242,
24,
222
]
],
[
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[
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46,
222
]
],
[
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29356
],
[
29356,
60,
222
]
],
[
[
1242,
24,
1563
],
[
1563... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Cetirizine",
"{u} (Compound) upregulates {v} (Gene)",
"CDK6"
],
[
"CDK6",
"{u} (Gene) is upregulated by {v} (Co... | Cetirizine (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Sibutramine (Compound)
Cetirizine (Compound) causes Salivary hypersecretion (Side Effect) and Salivary hypersecretion (Side Effect) is caused by Sibutramine (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseas... |
DB00026 | DB00888 | 1,184 | 1,001 | [
"DDInter94",
"DDInter1133"
] | Anakinra | Mechlorethamine | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Moderate | 1 | [
[
[
1184,
24,
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]
],
[
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1184,
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[
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[
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[
126,
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[
[
1184,
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],
[
51,
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[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mechlorethamine"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclophosphamide"
],
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Cyclophosphamide and Cyclophosphamide (Compound) resembles Mechlorethamine (Compound)
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that... |
DB00046 | DB14731 | 1,179 | 1,518 | [
"DDInter940",
"DDInter1741"
] | Insulin lispro | Tagraxofusp | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Tagraxofusp is a CD123-directed cytotoxin. It is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in _Escherichia coli_.[A253762, A253887, L43702] Tagraxofusp received its first global approval by t... | Moderate | 1 | [
[
[
1179,
24,
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[
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[
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[
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1179,
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695
],
[
695,
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1518
]
],
[
[
1179,
24,
123
],
[
123,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tagraxofusp"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
],
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Tagraxofusp
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and ... |
DB06168 | DB14711 | 1,531 | 779 | [
"DDInter281",
"DDInter1680"
] | Canakinumab | Smallpox (Vaccinia) Vaccine, Live | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
1531,
25,
779
]
],
[
[
1531,
64,
1064
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[
1064,
25,
779
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[
[
1531,
63,
478
],
[
478,
25,
779
]
],
[
[
1531,
25,
1259
],
[
1259,
... | [
[
[
"Canakinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Canakinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"... | Canakinumab may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib ma... |
DB14724 | DB14783 | 48 | 287 | [
"DDInter634",
"DDInter574"
] | Emapalumab | Diroximel fumarate | Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
48,
24,
287
]
],
[
[
48,
63,
1456
],
[
1456,
24,
287
]
],
[
[
48,
63,
713
],
[
713,
25,
287
]
],
[
[
48,
63,
1456
],
[
1456,
63,... | [
[
[
"Emapalumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Emapalumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
],
... | Emapalumab may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax and Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Emapalumab may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fuma... |
DB00999 | DB06655 | 504 | 5 | [
"DDInter883",
"DDInter1077"
] | Hydrochlorothiazide | Liraglutide | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
504,
24,
5
]
],
[
[
504,
63,
870
],
[
870,
24,
5
]
],
[
[
504,
1,
1326
],
[
1326,
24,
5
]
],
[
[
504,
24,
708
],
[
708,
24,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludroco... | Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Hydrochlorothiazide (Compound) resembles Diclofenamide (Compound) and Diclofenamide may caus... |
DB00655 | DB12130 | 559 | 1,017 | [
"DDInter682",
"DDInter1094"
] | Estrone | Lorlatinib | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
559,
24,
1017
]
],
[
[
559,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
559,
63,
175
],
[
175,
24,
1017
]
],
[
[
559,
24,
126
],
[
126,
... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"B... | Estrone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Estrone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolo... |
DB01175 | DB06704 | 318 | 247 | [
"DDInter672",
"DDInter951"
] | Escitalopram | Iobenguane (I-123) | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
318,
24,
247
]
],
[
[
318,
6,
7390
],
[
7390,
45,
247
]
],
[
[
318,
21,
28787
],
[
28787,
60,
247
]
],
[
[
318,
25,
820
],
[
820,
... | [
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iobenguane"
]
],
[
[
"Escitalopram",
"{u} (Compound) binds {v} (Gene)",
"SLC6A2"
],
[
"SLC6A2",
"{u} (Gene) is bound by {v} (Compoun... | Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Escitalopram (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Escitalopram (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iobenguane (Compound)
... |
DB01576 | DB09481 | 93 | 460 | [
"DDInter526",
"DDInter1113"
] | Dextroamphetamine | Magnesium carbonate | Dextroamphetamine is the dextrorotatory enantiomer of amphetamine. Dextroamphetamine was approved by the FDA in 2001 for the treatment of attention deficit hyperactivity disorder[L6010,Label]. | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
93,
24,
460
]
],
[
[
93,
63,
401
],
[
401,
23,
460
]
],
[
[
93,
1,
80
],
[
80,
24,
460
]
],
[
[
93,
63,
542
],
[
542,
24,
... | [
[
[
"Dextroamphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Dextroamphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prom... | Dextroamphetamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Dextroamphetamine (Compound) resembles Amphetamine (Compound) and Amphetamine may cause a mode... |
DB00563 | DB01149 | 663 | 851 | [
"DDInter1174",
"DDInter1274"
] | Methotrexate | Nefazodone | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Moderate | 1 | [
[
[
663,
24,
851
]
],
[
[
663,
6,
4973
],
[
4973,
45,
851
]
],
[
[
663,
18,
3390
],
[
3390,
57,
851
]
],
[
[
663,
21,
29366
],
[
29366,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
]
],
[
[
"Methotrexate",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)... | Methotrexate (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nefazodone (Compound)
Methotrexate (Compound) downregulates RPN1 (Gene) and RPN1 (Gene) is downregulated by Nefazodone (Compound)
Methotrexate (Compound) causes Dysuria (Side Effect) and Dysuria (Side Effect) is caused by Nefazodone (Compound)
Meth... |
DB00543 | DB01218 | 87 | 1,493 | [
"DDInter82",
"DDInter852"
] | Amoxapine | Halofantrine | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
87,
25,
1493
]
],
[
[
87,
6,
12523
],
[
12523,
45,
1493
]
],
[
[
87,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
87,
23,
112
],
[
112,
... | [
[
[
"Amoxapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Amoxapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Halofan... | Amoxapine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Halofantrine (Compound)
Amoxapine (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Amoxapine may cause a minor interaction that can limit clinical effects when taken w... |
DB09331 | DB10316 | 745 | 334 | [
"DDInter478",
"DDInter1248"
] | Daratumumab | Mumps virus strain B level jeryl lynn live antigen | Daratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of its kind. Daratumumab was granted FDA approval on 16 November 2015. It is approved for the trea... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
745,
25,
334
]
],
[
[
745,
64,
1057
],
[
1057,
25,
334
]
],
[
[
745,
63,
599
],
[
599,
25,
334
]
],
[
[
745,
25,
1259
],
[
1259,
... | [
[
[
"Daratumumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Daratumumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Daratumumab may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Daratumumab may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzum... |
DB00902 | DB01324 | 104 | 178 | [
"DDInter1168",
"DDInter1490"
] | Methdilazine | Polythiazide | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
104,
24,
178
]
],
[
[
104,
24,
504
],
[
504,
40,
178
]
],
[
[
104,
63,
359
],
[
359,
40,
178
]
],
[
[
104,
63,
85
],
[
85,
23,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Polythiazide (Compound)
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) ... |
DB00023 | DB10276 | 305 | 1,624 | [
"DDInter127",
"DDInter1623"
] | Asparaginase Escherichia coli | Rotavirus vaccine | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
305,
25,
1624
]
],
[
[
305,
24,
617
],
[
617,
24,
1624
]
],
[
[
305,
24,
552
],
[
552,
25,
1624
]
],
[
[
305,
25,
770
],
[
770,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate d... |
DB00595 | DB00703 | 1,545 | 997 | [
"DDInter1374",
"DDInter1167"
] | Oxytetracycline | Methazolamide | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Minor | 0 | [
[
[
1545,
23,
997
]
],
[
[
1545,
23,
471
],
[
471,
1,
997
]
],
[
[
1545,
6,
10612
],
[
10612,
45,
997
]
],
[
[
1545,
40,
1572
],
[
1572,
... | [
[
[
"Oxytetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Methazolamide"
]
],
[
[
"Oxytetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetazolamide"
... | Oxytetracycline may cause a minor interaction that can limit clinical effects when taken with Acetazolamide and Acetazolamide (Compound) resembles Methazolamide (Compound)
Oxytetracycline (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Methazolamide (Compound)
Oxytetracycline (Compound) resembles Demeclo... |
DB00023 | DB01438 | 305 | 585 | [
"DDInter127",
"DDInter1438"
] | Asparaginase Escherichia coli | Phenazopyridine | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Phenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management of urinary tract irritation and its associated unpleasant symptoms such as burning and pain during urination. In the USA, this drug was previously marked by Roche but has been discontinued by the FDA. It is still us... | Moderate | 1 | [
[
[
305,
24,
585
]
],
[
[
305,
24,
384
],
[
384,
63,
585
]
],
[
[
305,
24,
372
],
[
372,
24,
585
]
],
[
[
305,
25,
1510
],
[
1510,
6... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenazopyridine"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wi... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Phenazopyridine
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate dis... |
DB00619 | DB00801 | 1,419 | 1,563 | [
"DDInter909",
"DDInter850"
] | Imatinib | Halazepam | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.[A1212, A178114] It has been shown to be less toxic than chlordiazepoxide or diazepam. This drug is no longer marketed in the United States, and was withdrawn by _Schering_, its manufacturer, in 2009... | Moderate | 1 | [
[
[
1419,
24,
1563
]
],
[
[
1419,
63,
902
],
[
902,
40,
1563
]
],
[
[
1419,
63,
523
],
[
523,
1,
1563
]
],
[
[
1419,
24,
1216
],
[
1216,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halazepam"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clobazam"
],
[
"Cl... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Halazepam (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam (Compound) resembles Halazepam (Compound)
Imatinib m... |
DB06595 | DB09472 | 1,491 | 1,383 | [
"DDInter1214",
"DDInter1693"
] | Midostaurin | Sodium sulfate | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1491,
24,
1383
]
],
[
[
1491,
63,
1252
],
[
1252,
23,
1383
]
],
[
[
1491,
64,
609
],
[
609,
24,
1383
]
],
[
[
1491,
63,
521
],
[
521,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Sodium sulfate
Midostaurin may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may ... |
DB01577 | DB06704 | 1,529 | 247 | [
"DDInter1161",
"DDInter952"
] | Metamfetamine | Iobenguane (I-131) | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Major | 2 | [
[
[
1529,
37,
247
]
],
[
[
1529,
6,
7390
],
[
7390,
45,
247
]
],
[
[
1529,
21,
28921
],
[
28921,
60,
247
]
],
[
[
1529,
63,
820
],
[
820,
... | [
[
[
"Metamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Metamfetamine",
"{u} (Compound) binds {v} (Gene)",
"... | Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Metamfetamine may lead to a major life threatening interaction when taken with Iobenguane
Metamfetamine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Metamfetamine (Compound)... |
DB00497 | DB01259 | 828 | 392 | [
"DDInter1366",
"DDInter1024"
] | Oxycodone | Lapatinib | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
828,
24,
392
]
],
[
[
828,
6,
8374
],
[
8374,
45,
392
]
],
[
[
828,
21,
29429
],
[
29429,
60,
392
]
],
[
[
828,
24,
918
],
[
918,
... | [
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Oxycodone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Oxycodone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Oxycodone (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Lapatinib (Compound)
Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide... |
DB00819 | DB01088 | 471 | 714 | [
"DDInter15",
"DDInter908"
] | Acetazolamide | Iloprost | One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its ... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
471,
24,
714
]
],
[
[
471,
25,
1479
],
[
1479,
24,
714
]
],
[
[
471,
63,
1648
],
[
1648,
24,
714
]
],
[
[
471,
24,
1450
],
[
1450,
... | [
[
[
"Acetazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Acetazolamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acetylsalicylic acid"
],
[
... | Acetazolamide may lead to a major life threatening interaction when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Acetazolamide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin ... |
DB01265 | DB05773 | 1,477 | 1,047 | [
"DDInter1757",
"DDInter1848"
] | Telbivudine | Trastuzumab emtansine | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
1477,
24,
1047
]
],
[
[
1477,
63,
848
],
[
848,
24,
1047
]
],
[
[
1477,
24,
375
],
[
375,
63,
1047
]
],
[
[
1477,
64,
491
],
[
491,
... | [
[
[
"Telbivudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Telbivudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
... | Telbivudine may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Telbivudine may cause a moderate interaction that could exacerbate diseases when taken with Certolizum... |
DB06688 | DB11703 | 1,430 | 405 | [
"DDInter1677",
"DDInter9"
] | Sipuleucel-T | Acalabrutinib | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
1430,
24,
405
]
],
[
[
1430,
63,
139
],
[
139,
24,
405
]
],
[
[
1430,
24,
951
],
[
951,
24,
405
]
],
[
[
1430,
24,
1619
],
[
1619,
... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
],
... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib an... |
DB00365 | DB11901 | 839 | 913 | [
"DDInter842",
"DDInter107"
] | Grepafloxacin | Apalutamide | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
839,
25,
913
]
],
[
[
839,
23,
112
],
[
112,
23,
913
]
],
[
[
839,
64,
600
],
[
600,
24,
913
]
],
[
[
839,
24,
303
],
[
303,
24,... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Me... | Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Grepafloxacin may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole... |
DB00476 | DB04837 | 109 | 649 | [
"DDInter608",
"DDInter407"
] | Duloxetine | Clofedanol | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
109,
24,
649
]
],
[
[
109,
24,
1376
],
[
1376,
24,
649
]
],
[
[
109,
40,
11247
],
[
11247,
40,
649
]
],
[
[
109,
63,
701
],
[
701,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Duloxetine (Compound) resembles Naftifine (Compound) and Naftifine (Compound) resembles Clofedanol (Co... |
DB01168 | DB01192 | 1,053 | 560 | [
"DDInter1526",
"DDInter1372"
] | Procarbazine | Oxymorphone | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Major | 2 | [
[
[
1053,
25,
560
]
],
[
[
1053,
64,
828
],
[
828,
1,
560
]
],
[
[
1053,
21,
28936
],
[
28936,
60,
560
]
],
[
[
1053,
63,
104
],
[
104,
... | [
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oxymorphone"
]
],
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oxycodone"
],
[
"Oxycodone",
"{u... | Procarbazine may lead to a major life threatening interaction when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Procarbazine (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Oxymorphone (Compound)
Procarbazine may cause a moderate interaction t... |
DB00290 | DB00888 | 329 | 1,001 | [
"DDInter219",
"DDInter1133"
] | Bleomycin | Mechlorethamine | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Moderate | 1 | [
[
[
329,
24,
1001
]
],
[
[
329,
24,
450
],
[
450,
1,
1001
]
],
[
[
329,
5,
11555
],
[
11555,
44,
1001
]
],
[
[
329,
21,
28725
],
[
28725,
... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mechlorethamine"
]
],
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclophosphamide"
],... | Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Cyclophosphamide and Cyclophosphamide (Compound) resembles Mechlorethamine (Compound)
Bleomycin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Mechlorethamine (Compound)
Bleomycin (Co... |
DB08907 | DB09112 | 1,344 | 1,455 | [
"DDInter280",
"DDInter1306"
] | Canagliflozin | Nitrous acid | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
1344,
24,
1455
]
],
[
[
1344,
63,
312
],
[
312,
24,
1455
]
],
[
[
1344,
24,
947
],
[
947,
24,
1455
]
],
[
[
1344,
24,
1586
],
[
1586,
... | [
[
[
"Canagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Canagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eplerenone"
],
... | Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Riociguat and... |
DB00780 | DB01114 | 551 | 272 | [
"DDInter1440",
"DDInter362"
] | Phenelzine | Chlorpheniramine | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
551,
24,
272
]
],
[
[
551,
24,
849
],
[
849,
63,
272
]
],
[
[
551,
63,
128
],
[
128,
24,
272
]
],
[
[
551,
6,
8374
],
[
8374,
45... | [
[
[
"Phenelzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Phenelzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Phenelzine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Phenelzine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniram... |
DB00554 | DB00731 | 1,027 | 1,144 | [
"DDInter1478",
"DDInter1269"
] | Piroxicam | Nateglinide | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
1027,
24,
1144
]
],
[
[
1027,
6,
1829
],
[
1829,
45,
1144
]
],
[
[
1027,
24,
121
],
[
121,
24,
1144
]
],
[
[
1027,
24,
1033
],
[
1033,... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Piroxicam",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
... | Piroxicam (Compound) binds ALB (Gene) and ALB (Gene) is bound by Nateglinide (Compound)
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide
Piroxicam may cause ... |
DB00853 | DB14444 | 1,686 | 151 | [
"DDInter1762",
"DDInter924"
] | Temozolomide | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1686,
24,
151
]
],
[
[
1686,
63,
66
],
[
66,
24,
151
]
],
[
[
1686,
24,
850
],
[
850,
24,
151
]
],
[
[
1686,
25,
375
],
[
375,
2... | [
[
[
"Temozolomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Temozolomide",
"{u} may cause a moderate interaction that cou... | Temozolomide may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Temozolomide may cause a moderate i... |
DB00197 | DB08899 | 1,324 | 129 | [
"DDInter1881",
"DDInter649"
] | Troglitazone | Enzalutamide | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1324,
24,
129
]
],
[
[
1324,
23,
271
],
[
271,
23,
129
]
],
[
[
1324,
23,
1459
],
[
1459,
62,
129
]
],
[
[
1324,
24,
1060
],
[
1060,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Troglitazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
... | Troglitazone may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Enzalutamide
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Dolutegravir and Dolu... |
DB00159 | DB06754 | 940 | 707 | [
"DDInter903",
"DDInter471"
] | Icosapent | Danaparoid | Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conve... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Moderate | 1 | [
[
[
940,
24,
707
]
],
[
[
940,
24,
235
],
[
235,
64,
707
]
],
[
[
940,
24,
702
],
[
702,
25,
707
]
],
[
[
940,
63,
1271
],
[
1271,
2... | [
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danaparoid"
]
],
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desirudin"
],
[
... | Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Desirudin and Desirudin may lead to a major life threatening interaction when taken with Danaparoid
Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Anagrelide and Anagrelide may lead to a ... |
DB00798 | DB01135 | 1,132 | 648 | [
"DDInter815",
"DDInter590"
] | Gentamicin | Doxacurium | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration. | Major | 2 | [
[
[
1132,
25,
648
]
],
[
[
1132,
25,
1319
],
[
1319,
40,
648
]
],
[
[
1132,
64,
1441
],
[
1441,
24,
648
]
],
[
[
1132,
63,
1287
],
[
1287,... | [
[
[
"Gentamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxacurium"
]
],
[
[
"Gentamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mivacurium"
],
[
"Mivacurium",
"{u} (... | Gentamicin may lead to a major life threatening interaction when taken with Mivacurium and Mivacurium (Compound) resembles Doxacurium (Compound)
Gentamicin may lead to a major life threatening interaction when taken with Bacitracin and Bacitracin may cause a moderate interaction that could exacerbate diseases when take... |
DB00495 | DB05679 | 139 | 1,683 | [
"DDInter1961",
"DDInter1907"
] | Zidovudine | Ustekinumab | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
139,
24,
1683
]
],
[
[
139,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
139,
24,
281
],
[
281,
24,
1683
]
],
[
[
139,
63,
305
],
[
305,
... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Levamisole and Levamisol... |
DB00364 | DB01132 | 417 | 1,130 | [
"DDInter1717",
"DDInter1472"
] | Sucralfate | Pioglitazone | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
417,
24,
1130
]
],
[
[
417,
21,
28845
],
[
28845,
60,
1130
]
],
[
[
417,
23,
1072
],
[
1072,
24,
1130
]
],
[
[
417,
63,
362
],
[
362,
... | [
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Sucralfate",
"{u} (Compound) causes {v} (Side Effect)",
"Oedema"
],
[
"Oedema",
"{u} (Side Effect) is caused b... | Sucralfate (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Pioglitazone (Compound)
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Isoniazid and Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone
Su... |
DB00307 | DB10583 | 1,101 | 949 | [
"DDInter202",
"DDInter415"
] | Bexarotene | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
1101,
24,
949
]
],
[
[
1101,
25,
1377
],
[
1377,
24,
949
]
],
[
[
1101,
63,
58
],
[
58,
24,
949
]
],
[
[
1101,
24,
663
],
[
663,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",... | Bexarotene may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Bexarotene may cause a moderate interaction that could exacerbate diseases ... |
DB00675 | DB01232 | 888 | 1,327 | [
"DDInter1744",
"DDInter1640"
] | Tamoxifen | Saquinavir | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Major | 2 | [
[
[
888,
25,
1327
]
],
[
[
888,
63,
798
],
[
798,
40,
1327
]
],
[
[
888,
6,
10215
],
[
10215,
45,
1327
]
],
[
[
888,
21,
28936
],
[
28936,... | [
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
"Nelfinavir",... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Tamoxifen (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Saquinavir (Compound)
Tamoxifen (Compound) causes Hyperhidrosis (Side Effect) and Hyperh... |
DB00421 | DB09075 | 443 | 498 | [
"DDInter1707",
"DDInter621"
] | Spironolactone | Edoxaban | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
443,
25,
498
]
],
[
[
443,
24,
222
],
[
222,
24,
498
]
],
[
[
443,
24,
738
],
[
738,
63,
498
]
],
[
[
443,
25,
1456
],
[
1456,
6... | [
[
[
"Spironolactone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sib... | Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and... |
DB00818 | DB08912 | 898 | 1,040 | [
"DDInter1538",
"DDInter462"
] | Propofol | Dabrafenib | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
898,
24,
1040
]
],
[
[
898,
6,
3486
],
[
3486,
45,
1040
]
],
[
[
898,
18,
7247
],
[
7247,
46,
1040
]
],
[
[
898,
21,
28900
],
[
28900,... | [
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Propofol",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Propofol (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Dabrafenib (Compound)
Propofol (Compound) downregulates NPDC1 (Gene) and NPDC1 (Gene) is upregulated by Dabrafenib (Compound)
Propofol (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
... |
DB00427 | DB14575 | 1,233 | 733 | [
"DDInter1879",
"DDInter674"
] | Triprolidine | Eslicarbazepine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
1233,
24,
733
]
],
[
[
1233,
24,
1264
],
[
1264,
24,
733
]
],
[
[
1233,
63,
1594
],
[
1594,
24,
733
]
],
[
[
1233,
24,
1264
],
[
1264,... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Eslicarbazepine
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Dox... |
DB00196 | DB00700 | 600 | 312 | [
"DDInter743",
"DDInter656"
] | Fluconazole | Eplerenone | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone c... | Major | 2 | [
[
[
600,
25,
312
]
],
[
[
600,
24,
167
],
[
167,
63,
312
]
],
[
[
600,
24,
989
],
[
989,
1,
312
]
],
[
[
600,
24,
1561
],
[
1561,
40... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eplerenone"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
[
"Hydr... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Progesteron... |
DB11793 | DB11828 | 738 | 1,406 | [
"DDInter1297",
"DDInter1281"
] | Niraparib | Neratinib | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
738,
24,
1406
]
],
[
[
738,
64,
1510
],
[
1510,
24,
1406
]
],
[
[
738,
24,
710
],
[
710,
63,
1406
]
],
[
[
738,
63,
985
],
[
985,
... | [
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Niraparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
],
[
"Teriflunom... | Niraparib may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib and Binimetinib may c... |
DB01254 | DB08827 | 1,213 | 990 | [
"DDInter484",
"DDInter1085"
] | Dasatinib | Lomitapide | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Moderate | 1 | [
[
[
1213,
24,
990
]
],
[
[
1213,
64,
1080
],
[
1080,
1,
990
]
],
[
[
1213,
6,
8374
],
[
8374,
45,
990
]
],
[
[
1213,
21,
28701
],
[
28701,... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomitapide"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
],
[
"Conivaptan",... | Dasatinib may lead to a major life threatening interaction when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Dasatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Dasatinib (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) i... |
DB00574 | DB11823 | 121 | 858 | [
"DDInter717",
"DDInter673"
] | Fenfluramine | Esketamine | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. Eske... | Major | 2 | [
[
[
121,
25,
858
]
],
[
[
121,
64,
506
],
[
506,
24,
858
]
],
[
[
121,
24,
1264
],
[
1264,
24,
858
]
],
[
[
121,
63,
13
],
[
13,
24,... | [
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Esketamine"
]
],
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextromethorphan"
],
[
"Dextromethorpha... | Fenfluramine may lead to a major life threatening interaction when taken with Dextromethorphan and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Esketamine
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin ... |
DB00831 | DB11130 | 1,178 | 407 | [
"DDInter1866",
"DDInter1344"
] | Trifluoperazine | Opium | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1178,
24,
407
]
],
[
[
1178,
63,
662
],
[
662,
24,
407
]
],
[
[
1178,
35,
104
],
[
104,
24,
407
]
],
[
[
1178,
24,
849
],
[
849,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Trifluoperazine (Compound) resembles Methdilazine (Compound) and Trifluoperazine may cause a moderate inte... |
DB00794 | DB08895 | 759 | 976 | [
"DDInter1521",
"DDInter1825"
] | Primidone | Tofacitinib | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
759,
25,
976
]
],
[
[
759,
25,
214
],
[
214,
63,
976
]
],
[
[
759,
63,
723
],
[
723,
24,
976
]
],
[
[
759,
24,
407
],
[
407,
63,... | [
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
],
[
"Fostamatinib",
"{u... | Primidone may lead to a major life threatening interaction when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cau... |
DB05541 | DB06282 | 801 | 516 | [
"DDInter239",
"DDInter1053"
] | Brivaracetam | Levocetirizine | Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam. It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016. | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
801,
24,
516
]
],
[
[
801,
63,
701
],
[
701,
24,
516
]
],
[
[
801,
24,
407
],
[
407,
63,
516
]
],
[
[
801,
63,
701
],
[
701,
23,... | [
[
[
"Brivaracetam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Brivaracetam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Brivaracetam may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Brivaracetam may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opi... |
DB00564 | DB11921 | 1,236 | 1,019 | [
"DDInter293",
"DDInter492"
] | Carbamazepine | Deflazacort | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
1236,
25,
1019
]
],
[
[
1236,
24,
270
],
[
270,
63,
1019
]
],
[
[
1236,
24,
761
],
[
761,
24,
1019
]
],
[
[
1236,
25,
629
],
[
629,
... | [
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
],
[
"Oc... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin ... |
DB00526 | DB04953 | 1,555 | 495 | [
"DDInter1355",
"DDInter708"
] | Oxaliplatin | Ezogabine | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Moderate | 1 | [
[
[
1555,
24,
495
]
],
[
[
1555,
24,
112
],
[
112,
23,
495
]
],
[
[
1555,
63,
1494
],
[
1494,
24,
495
]
],
[
[
1555,
24,
1148
],
[
1148,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ezogabine"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ezogabine
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Palonosetron and... |
DB00563 | DB01362 | 663 | 497 | [
"DDInter1174",
"DDInter960"
] | Methotrexate | Iohexol | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
663,
25,
497
]
],
[
[
663,
25,
258
],
[
258,
40,
497
]
],
[
[
663,
18,
6929
],
[
6929,
57,
497
]
],
[
[
663,
21,
28681
],
[
28681,
... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
],
[
"Iodixanol",
"{u} (C... | Methotrexate may lead to a major life threatening interaction when taken with Iodixanol and Iodixanol (Compound) resembles Iohexol (Compound)
Methotrexate (Compound) downregulates ITGAE (Gene) and ITGAE (Gene) is downregulated by Iohexol (Compound)
Methotrexate (Compound) causes Hypersensitivity (Side Effect) and Hyper... |
DB00108 | DB11581 | 1,066 | 1,456 | [
"DDInter1268",
"DDInter1926"
] | Natalizumab | Venetoclax | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
1066,
25,
1456
]
],
[
[
1066,
25,
259
],
[
259,
24,
1456
]
],
[
[
1066,
24,
1129
],
[
1129,
63,
1456
]
],
[
[
1066,
25,
1476
],
[
1476... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilonacept"
],
[
"Rilonacept",
"{u}... | Natalizumab may lead to a major life threatening interaction when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Natalizumab may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 stra... |
DB00655 | DB14723 | 559 | 159 | [
"DDInter682",
"DDInter1026"
] | Estrone | Larotrectinib | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
559,
24,
159
]
],
[
[
559,
24,
1619
],
[
1619,
24,
159
]
],
[
[
559,
1,
35
],
[
35,
24,
159
]
],
[
[
559,
63,
1419
],
[
1419,
24... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[
... | Estrone may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Estrone (Compound) resembles Quinestrol (Compound) and Quinestrol may cause a moderate interaction that could exac... |
DB00661 | DB11978 | 122 | 124 | [
"DDInter1928",
"DDInter822"
] | Verapamil | Glasdegib | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
122,
24,
124
]
],
[
[
122,
25,
1135
],
[
1135,
23,
124
]
],
[
[
122,
23,
466
],
[
466,
62,
124
]
],
[
[
122,
62,
475
],
[
475,
2... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Verapamil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Verapamil may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Verapamil may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a min... |
DB00986 | DB13913 | 1,192 | 1,536 | [
"DDInter834",
"DDInter175"
] | Glycopyrronium | Belladonna | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family _Solanaceae_. Its roots, leaves and fruits contain , , and mostly, . These alkaloids are naturally-occurring muscarinic antagonists. is a non-selective muscarinic antagonist that is mainly used as ... | Moderate | 1 | [
[
[
1192,
24,
1536
]
],
[
[
1192,
24,
849
],
[
849,
24,
1536
]
],
[
[
1192,
63,
128
],
[
128,
24,
1536
]
],
[
[
1192,
74,
352
],
[
352,
... | [
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belladonna"
]
],
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Belladonna
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Dexbromphenir... |
DB00275 | DB01142 | 217 | 1,264 | [
"DDInter1330",
"DDInter593"
] | Olmesartan | Doxepin | Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, w... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
217,
24,
1264
]
],
[
[
217,
24,
401
],
[
401,
24,
1264
]
],
[
[
217,
21,
29226
],
[
29226,
60,
1264
]
],
[
[
217,
63,
1648
],
[
1648,
... | [
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Olmesartan (Compound) causes Sinusitis (Side Effect) and Sinusitis (Side Effect) is caused by Doxepin (Compound... |
DB00282 | DB00994 | 641 | 361 | [
"DDInter1383",
"DDInter1277"
] | Pamidronic acid | Neomycin | Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid]. Pamidronic acid was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic ... | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Moderate | 1 | [
[
[
641,
24,
361
]
],
[
[
641,
21,
28722
],
[
28722,
60,
361
]
],
[
[
641,
24,
1132
],
[
1132,
24,
361
]
],
[
[
641,
1,
1485
],
[
1485,
... | [
[
[
"Pamidronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neomycin"
]
],
[
[
"Pamidronic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is ca... | Pamidronic acid (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Neomycin (Compound)
Pamidronic acid may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin and Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Neomy... |
DB06663 | DB08881 | 1,154 | 868 | [
"DDInter1398",
"DDInter1925"
] | Pasireotide | Vemurafenib | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1154,
25,
868
]
],
[
[
1154,
21,
29106
],
[
29106,
60,
868
]
],
[
[
1154,
63,
608
],
[
608,
23,
868
]
],
[
[
1154,
62,
112
],
[
112,
... | [
[
[
"Pasireotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Pasireotide",
"{u} (Compound) causes {v} (Side Effect)",
"Myalgia"
],
[
"Myalgia",
"{u} (Side Effect) is caused by {v} (Compo... | Pasireotide (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Vemurafenib (Compound)
Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Vemurafenib
... |
DB00775 | DB01381 | 1,226 | 958 | [
"DDInter1818",
"DDInter819"
] | Tirofiban | Ginkgo biloba | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
1226,
24,
958
]
],
[
[
1226,
64,
1347
],
[
1347,
24,
958
]
],
[
[
1226,
25,
1317
],
[
1317,
24,
958
]
],
[
[
1226,
63,
121
],
[
121,
... | [
[
[
"Tirofiban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Tirofiban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clopidogrel"
],
[
"Clopidog... | Tirofiban may lead to a major life threatening interaction when taken with Clopidogrel and Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Tirofiban may lead to a major life threatening interaction when taken with Dipyridamole and Dipyridamole may cause a modera... |
DB01159 | DB12332 | 419 | 1,619 | [
"DDInter854",
"DDInter1626"
] | Halothane | Rucaparib | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
419,
24,
1619
]
],
[
[
419,
62,
112
],
[
112,
23,
1619
]
],
[
[
419,
24,
1662
],
[
1662,
24,
1619
]
],
[
[
419,
63,
888
],
[
888,
... | [
[
[
"Halothane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Halothane",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Halothane may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Halothane may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and ... |
DB00451 | DB09481 | 542 | 460 | [
"DDInter1064",
"DDInter1113"
] | Levothyroxine | Magnesium carbonate | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
542,
24,
460
]
],
[
[
542,
63,
1252
],
[
1252,
23,
460
]
],
[
[
542,
62,
461
],
[
461,
23,
460
]
],
[
[
542,
23,
752
],
[
752,
2... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Timolol and Timo... |
DB00731 | DB08882 | 1,144 | 1,281 | [
"DDInter1269",
"DDInter1070"
] | Nateglinide | Linagliptin | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
1144,
24,
1281
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],
[
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[
1002,
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[
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[
11640,
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[
[
1144,
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[
837... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
[... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Nateglinide (Compound) treats type 2 diabetes mellitus (Disease) and type 2 diabetes mellitus (Disease) is treated by Linagliptin (Compound)
Nateglinide (Comp... |
DB00704 | DB11130 | 267 | 407 | [
"DDInter1263",
"DDInter1344"
] | Naltrexone | Opium | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Major | 2 | [
[
[
267,
25,
407
]
],
[
[
267,
63,
556
],
[
556,
24,
407
]
],
[
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267,
25,
1454
],
[
1454,
24,
407
]
],
[
[
267,
64,
576
],
[
576,
2... | [
[
[
"Naltrexone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Opium"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valproic acid"
],
[
"Valproic aci... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Valproic acid and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Opium
Naltrexone may lead to a major life threatening interaction when taken with Sufentanil and Sufentanil may cause... |
DB08815 | DB11901 | 154 | 913 | [
"DDInter1104",
"DDInter107"
] | Lurasidone | Apalutamide | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
154,
25,
913
]
],
[
[
154,
64,
600
],
[
600,
24,
913
]
],
[
[
154,
24,
1320
],
[
1320,
63,
913
]
],
[
[
154,
63,
1250
],
[
1250,
... | [
[
[
"Lurasidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Lurasidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
"Fluconazole",
"{u... | Lurasidone may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a... |
DB09407 | DB11110 | 853 | 603 | [
"DDInter1114",
"DDInter1115"
] | Magnesium chloride | Magnesium citrate | Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water. | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
853,
24,
603
]
],
[
[
853,
63,
246
],
[
246,
24,
603
]
],
[
[
853,
24,
933
],
[
933,
63,
603
]
],
[
[
853,
64,
1459
],
[
1459,
2... | [
[
[
"Magnesium chloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Magnesium chloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gati... | Magnesium chloride may cause a moderate interaction that could exacerbate diseases when taken with Gatifloxacin and Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Magnesium chloride may cause a moderate interaction that could exacerbate diseases when taken... |
DB00026 | DB06372 | 1,184 | 259 | [
"DDInter94",
"DDInter1594"
] | Anakinra | Rilonacept | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
1184,
24,
259
]
],
[
[
1184,
23,
1114
],
[
1114,
62,
259
]
],
[
[
1184,
23,
1461
],
[
1461,
23,
259
]
],
[
[
1184,
24,
0
],
[
0,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Anakinra",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
... | Anakinra may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Anakinra may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may... |
DB00673 | DB01591 | 723 | 667 | [
"DDInter112",
"DDInter1696"
] | Aprepitant | Solifenacin | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
723,
24,
667
]
],
[
[
723,
6,
8374
],
[
8374,
45,
667
]
],
[
[
723,
21,
28723
],
[
28723,
60,
667
]
],
[
[
723,
63,
1324
],
[
1324,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Aprepitant (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Solifenacin (Compound)
Aprepitant (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Solifenacin (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Troglitazon... |
DB01015 | DB01218 | 1,247 | 1,493 | [
"DDInter1724",
"DDInter852"
] | Sulfamethoxazole | Halofantrine | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Minor | 0 | [
[
[
1247,
23,
1493
]
],
[
[
1247,
6,
3486
],
[
3486,
45,
1493
]
],
[
[
1247,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
1247,
62,
112
],
[
11... | [
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Halofantrine"
]
],
[
[
"Sulfamethoxazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} ... | Sulfamethoxazole (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Halofantrine (Compound)
Sulfamethoxazole (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Sulfamethoxazole may cause a minor interaction that can limit clinical... |
DB01059 | DB01218 | 956 | 1,493 | [
"DDInter1313",
"DDInter852"
] | Norfloxacin | Halofantrine | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
956,
25,
1493
]
],
[
[
956,
6,
8374
],
[
8374,
45,
1493
]
],
[
[
956,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
956,
62,
112
],
[
112,
... | [
[
[
"Norfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Norfloxacin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Hal... | Norfloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Halofantrine (Compound)
Norfloxacin (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Norfloxacin may cause a minor interaction that can limit clinical effects when t... |
DB00564 | DB01501 | 1,236 | 1,118 | [
"DDInter293",
"DDInter549"
] | Carbamazepine | Difenoxin | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a ... | Moderate | 1 | [
[
[
1236,
24,
1118
]
],
[
[
1236,
24,
1688
],
[
1688,
40,
1118
]
],
[
[
1236,
63,
506
],
[
506,
24,
1118
]
],
[
[
1236,
1,
1335
],
[
1335,... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Difenoxin"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenoxylate"
],
... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Diphenoxylate and Diphenoxylate (Compound) resembles Difenoxin (Compound)
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate... |
DB08865 | DB08903 | 1,593 | 996 | [
"DDInter448",
"DDInter170"
] | Crizotinib | Bedaquiline | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Major | 2 | [
[
[
1593,
25,
996
]
],
[
[
1593,
6,
8374
],
[
8374,
45,
996
]
],
[
[
1593,
21,
29282
],
[
29282,
60,
996
]
],
[
[
1593,
63,
112
],
[
112,
... | [
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
]
],
[
[
"Crizotinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Bedaqu... | Crizotinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound)
Crizotinib (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Bedaquiline (Compound)
Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole a... |
DB12141 | DB14723 | 971 | 159 | [
"DDInter817",
"DDInter1026"
] | Gilteritinib | Larotrectinib | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
971,
24,
159
]
],
[
[
971,
63,
479
],
[
479,
23,
159
]
],
[
[
971,
64,
318
],
[
318,
23,
159
]
],
[
[
971,
23,
466
],
[
466,
23,... | [
[
[
"Gilteritinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Gilteritinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
... | Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Gilteritinib may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may... |
DB00196 | DB11853 | 600 | 230 | [
"DDInter743",
"DDInter1577"
] | Fluconazole | Relugolix | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under th... | Moderate | 1 | [
[
[
600,
24,
230
]
],
[
[
600,
24,
129
],
[
129,
23,
230
]
],
[
[
600,
23,
112
],
[
112,
23,
230
]
],
[
[
600,
25,
1476
],
[
1476,
6... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Relugolix"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Relugolix
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Me... |
DB00005 | DB00069 | 1,057 | 367 | [
"DDInter687",
"DDInter946"
] | Etanercept | Interferon alfacon-1 | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Moderate | 1 | [
[
[
1057,
24,
367
]
],
[
[
1057,
25,
450
],
[
450,
62,
367
]
],
[
[
1057,
24,
467
],
[
467,
63,
367
]
],
[
[
1057,
25,
305
],
[
305,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon alfacon-1"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cyclophosphamide"
],
[
... | Etanercept may lead to a major life threatening interaction when taken with Cyclophosphamide and Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Interferon alfacon-1
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and ... |
DB00373 | DB06663 | 461 | 1,154 | [
"DDInter1809",
"DDInter1398"
] | Timolol | Pasireotide | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Moderate | 1 | [
[
[
461,
24,
1154
]
],
[
[
461,
63,
966
],
[
966,
40,
1154
]
],
[
[
461,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
461,
24,
959
],
[
959,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
[
"... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Timolol (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Timolol may cause a moderate interacti... |
DB00490 | DB11186 | 946 | 1,609 | [
"DDInter254",
"DDInter1427"
] | Buspirone | Pentoxyverine | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
946,
24,
1609
]
],
[
[
946,
24,
104
],
[
104,
24,
1609
]
],
[
[
946,
63,
999
],
[
999,
24,
1609
]
],
[
[
946,
25,
1264
],
[
1264,
... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[... | Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine... |
DB10276 | DB14004 | 1,624 | 398 | [
"DDInter1623",
"DDInter1806"
] | Rotavirus vaccine | Tildrakizumab | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Tildrakizumab is a high-affinity, humanized, IgG1 κ antibody targeting interleukin 23 p19 that shows promise in the evolution of treatment strategy in chronic plaque psoriasis . The Food and Drug Administration (FDA) approved ILUMYA (tildrakizumab-asmn) for the treatment of adults with moderate-to-severe plaque psorias... | Major | 2 | [
[
[
1624,
25,
398
]
],
[
[
1624,
64,
58
],
[
58,
24,
398
]
],
[
[
1624,
25,
270
],
[
270,
24,
398
]
],
[
[
1624,
64,
375
],
[
375,
2... | [
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tildrakizumab"
]
],
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alefacept"
],
[
"Alefacept... | Rotavirus vaccine may lead to a major life threatening interaction when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Tildrakizumab
Rotavirus vaccine may lead to a major life threatening interaction when taken with Ocrelizumab and Ocrelizumab may caus... |
DB01181 | DB11160 | 1,532 | 337 | [
"DDInter906",
"DDInter1459"
] | Ifosfamide | Phenyltoloxamine | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Moderate | 1 | [
[
[
1532,
24,
337
]
],
[
[
1532,
24,
820
],
[
820,
24,
337
]
],
[
[
1532,
63,
999
],
[
999,
24,
337
]
],
[
[
1532,
64,
770
],
[
770,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Phenyltoloxamine
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperaz... |
DB00621 | DB04951 | 1,026 | 187 | [
"DDInter1357",
"DDInter1477"
] | Oxandrolone | Pirfenidone | A synthetic hormone with anabolic and androgenic properties. | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Moderate | 1 | [
[
[
1026,
24,
187
]
],
[
[
1026,
24,
637
],
[
637,
63,
187
]
],
[
[
1026,
63,
663
],
[
663,
24,
187
]
],
[
[
1026,
24,
372
],
[
372,
... | [
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pirfenidone"
]
],
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chr... | Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi and Asparaginase Erwinia chrysanthemi may cause a moderate interaction that could exacerbate diseases when taken with Pirfenidone
Oxandrolone may cause a moderate interaction that could exacerba... |
DB00331 | DB14730 | 1,645 | 1,412 | [
"DDInter1164",
"DDInter264"
] | Metformin | Calaspargase pegol | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1645,
24,
1412
]
],
[
[
1645,
24,
1144
],
[
1144,
24,
1412
]
],
[
[
1645,
62,
1647
],
[
1647,
24,
1412
]
],
[
[
1645,
63,
1685
],
[
16... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Metformin may cause a minor interaction that can limit clinical effects when taken with Acarbose and Ac... |
DB00860 | DB06688 | 891 | 1,430 | [
"DDInter1513",
"DDInter1677"
] | Prednisolone | Sipuleucel-T | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
891,
24,
1430
]
],
[
[
891,
1,
175
],
[
175,
24,
1430
]
],
[
[
891,
25,
676
],
[
676,
63,
1430
]
],
[
[
891,
24,
1531
],
[
1531,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Prednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Triamcinolone"
],
[
"Triamcinolone",
"{u} may cau... | Prednisolone (Compound) resembles Triamcinolone (Compound) and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Prednisolone may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a moderate interaction that coul... |
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