drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00712 | DB09068 | 1,274 | 1,427 | [
"DDInter763",
"DDInter1948"
] | Flurbiprofen | Vortioxetine | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
1274,
24,
1427
]
],
[
[
1274,
63,
25
],
[
25,
24,
1427
]
],
[
[
1274,
25,
256
],
[
256,
24,
1427
]
],
[
[
1274,
24,
477
],
[
477,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anistreplase"
],
... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Flurbiprofen may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel ma... |
DB02546 | DB11827 | 137 | 433 | [
"DDInter1947",
"DDInter669"
] | Vorinostat | Ertugliflozin | Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new clas... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
137,
24,
433
]
],
[
[
137,
63,
959
],
[
959,
24,
433
]
],
[
[
137,
24,
1296
],
[
1296,
24,
433
]
],
[
[
137,
63,
959
],
[
959,
6... | [
[
[
"Vorinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Vorinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Vorinostat may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Vorinostat may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and... |
DB00612 | DB09133 | 1,121 | 1,527 | [
"DDInter216",
"DDInter965"
] | Bisoprolol | Iothalamic acid | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Moderate | 1 | [
[
[
1121,
24,
1527
]
],
[
[
1121,
24,
278
],
[
278,
63,
1527
]
],
[
[
1121,
1,
887
],
[
887,
24,
1527
]
],
[
[
1121,
24,
512
],
[
512,
... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopodic acid"
],
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid and Iopodic acid may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Bisoprolol (Compound) resembles Pindolol (Compound) and Pindolol may cause a moderate interaction that ... |
DB00420 | DB04843 | 508 | 1,511 | [
"DDInter1532",
"DDInter1149"
] | Promazine | Mepenzolate | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
508,
24,
1511
]
],
[
[
508,
24,
1192
],
[
1192,
24,
1511
]
],
[
[
508,
63,
352
],
[
352,
24,
1511
]
],
[
[
508,
40,
649
],
[
649,
... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
],
[... | Promazine may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium and Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and T... |
DB11581 | DB11901 | 1,456 | 913 | [
"DDInter1926",
"DDInter107"
] | Venetoclax | Apalutamide | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
1456,
25,
913
]
],
[
[
1456,
64,
271
],
[
271,
23,
913
]
],
[
[
1456,
64,
600
],
[
600,
24,
913
]
],
[
[
1456,
24,
1320
],
[
1320,
... | [
[
[
"Venetoclax",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Venetoclax",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mirabegron"
],
[
"Mirabegron",
"{u} ... | Venetoclax may lead to a major life threatening interaction when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Venetoclax may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate int... |
DB00472 | DB00526 | 758 | 1,555 | [
"DDInter758",
"DDInter1355"
] | Fluoxetine | Oxaliplatin | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
758,
24,
1555
]
],
[
[
758,
6,
7950
],
[
7950,
45,
1555
]
],
[
[
758,
63,
79
],
[
79,
24,
1555
]
],
[
[
758,
24,
1213
],
[
1213,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Fluoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)"... | Fluoxetine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Oxaliplatin (Compound)
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Fluoxetine may cau... |
DB06643 | DB12015 | 1,136 | 1,033 | [
"DDInter500",
"DDInter53"
] | Denosumab | Alpelisib | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1136,
24,
1033
]
],
[
[
1136,
24,
738
],
[
738,
24,
1033
]
],
[
[
1136,
63,
322
],
[
322,
24,
1033
]
],
[
[
1136,
64,
1064
],
[
1064,
... | [
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
[
... | Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin ... |
DB00719 | DB14740 | 1,219 | 771 | [
"DDInter149",
"DDInter881"
] | Azatadine | Hyaluronidase | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
1219,
23,
771
]
],
[
[
1219,
24,
849
],
[
849,
23,
771
]
],
[
[
1219,
63,
1242
],
[
1242,
23,
771
]
],
[
[
1219,
1,
1601
],
[
1601,
... | [
[
[
"Azatadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetiriz... |
DB00358 | DB00607 | 1,010 | 1,249 | [
"DDInter1140",
"DDInter1256"
] | Mefloquine | Nafcillin | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Moderate | 1 | [
[
[
1010,
24,
1249
]
],
[
[
1010,
23,
339
],
[
339,
1,
1249
]
],
[
[
1010,
6,
8374
],
[
8374,
45,
1249
]
],
[
[
1010,
21,
28792
],
[
28792... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nafcillin"
]
],
[
[
"Mefloquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bacampicillin"
],
[
... | Mefloquine may cause a minor interaction that can limit clinical effects when taken with Bacampicillin and Bacampicillin (Compound) resembles Nafcillin (Compound)
Mefloquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nafcillin (Compound)
Mefloquine (Compound) causes Gastrointestinal disorder (Side Eff... |
DB01165 | DB01309 | 1,539 | 1,254 | [
"DDInter1325",
"DDInter933"
] | Ofloxacin | Insulin glulisine | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Major | 2 | [
[
[
1539,
25,
1254
]
],
[
[
1539,
63,
1424
],
[
1424,
24,
1254
]
],
[
[
1539,
64,
167
],
[
167,
24,
1254
]
],
[
[
1539,
25,
1220
],
[
1220... | [
[
[
"Ofloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
[
"Quinine"... | Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Ofloxacin may lead to a major life threatening interaction when taken with Hydrocortisone and Hydrocortisone may... |
DB08895 | DB08913 | 976 | 1,186 | [
"DDInter1825",
"DDInter1561"
] | Tofacitinib | Radium Ra 223 dichloride | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
976,
24,
1186
]
],
[
[
976,
64,
37
],
[
37,
24,
1186
]
],
[
[
976,
25,
1583
],
[
1583,
63,
1186
]
],
[
[
976,
25,
1468
],
[
1468,
... | [
[
[
"Tofacitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomustine"
],
[
... | Tofacitinib may lead to a major life threatening interaction when taken with Lomustine and Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 dichloride
Tofacitinib may lead to a major life threatening interaction when taken with Sarilumab and Sarilumab may cause a m... |
DB00035 | DB00476 | 1,314 | 109 | [
"DDInter507",
"DDInter608"
] | Desmopressin | Duloxetine | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Moderate | 1 | [
[
[
1314,
24,
109
]
],
[
[
1314,
24,
758
],
[
758,
1,
109
]
],
[
[
1314,
21,
28783
],
[
28783,
60,
109
]
],
[
[
1314,
24,
1574
],
[
1574,
... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
]
],
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
],
... | Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fluoxetine (Compound) resembles Duloxetine (Compound)
Desmopressin (Compound) causes Oropharyngeal pain (Side Effect) and Oropharyngeal pain (Side Effect) is caused by Duloxetine (Compound)
Desmopressin may cause... |
DB00001 | DB01138 | 1,578 | 804 | [
"DDInter1037",
"DDInter1726"
] | Lepirudin | Sulfinpyrazone | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Major | 2 | [
[
[
1578,
25,
804
]
],
[
[
1578,
24,
998
],
[
998,
1,
804
]
],
[
[
1578,
25,
582
],
[
582,
24,
804
]
],
[
[
1578,
24,
1274
],
[
1274,
... | [
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sulfinpyrazone"
]
],
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
],
[
"Phen... | Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Sulfinpyrazone (Compound)
Lepirudin may lead to a major life threatening interaction when taken with Reteplase and Reteplase may cause a moderate interaction that could exacer... |
DB00420 | DB06655 | 508 | 5 | [
"DDInter1532",
"DDInter1077"
] | Promazine | Liraglutide | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
508,
24,
5
]
],
[
[
508,
24,
870
],
[
870,
24,
5
]
],
[
[
508,
63,
245
],
[
245,
24,
5
]
],
[
[
508,
40,
1630
],
[
1630,
24,
... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Promazine may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride ... |
DB01067 | DB14731 | 959 | 1,518 | [
"DDInter826",
"DDInter1741"
] | Glipizide | Tagraxofusp | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Tagraxofusp is a CD123-directed cytotoxin. It is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in _Escherichia coli_.[A253762, A253887, L43702] Tagraxofusp received its first global approval by t... | Moderate | 1 | [
[
[
959,
24,
1518
]
],
[
[
959,
24,
123
],
[
123,
24,
1518
]
],
[
[
959,
63,
176
],
[
176,
24,
1518
]
],
[
[
959,
40,
1411
],
[
1411,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tagraxofusp"
]
],
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
],
[
... | Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Tagraxofusp
Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Ins... |
DB01174 | DB01176 | 697 | 537 | [
"DDInter1442",
"DDInter453"
] | Phenobarbital | Cyclizine | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
697,
24,
537
]
],
[
[
697,
63,
1242
],
[
1242,
24,
537
]
],
[
[
697,
63,
104
],
[
104,
1,
537
]
],
[
[
697,
24,
830
],
[
830,
1,... | [
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],
... | Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and... |
DB00814 | DB09135 | 1,171 | 1,211 | [
"DDInter1143",
"DDInter967"
] | Meloxicam | Ioxilan | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Major | 2 | [
[
[
1171,
25,
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[
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[
372,
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[
[
1171,
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629
],
[
629,
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[
[
"Meloxicam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioxilan"
]
],
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],
[
"Olsalazine",
... | Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine may lead to a major life threatening interaction when taken with Ioxilan
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may lead to a... |
DB00444 | DB01320 | 63 | 651 | [
"DDInter1765",
"DDInter783"
] | Teniposide | Fosphenytoin | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
63,
24,
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]
],
[
[
63,
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[
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[
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362,
1,
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],
[
[
63,
6,
6017
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[
6017,
45,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Teniposide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Teniposide may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Fosphenytoin (Compound)
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Te... |
DB00656 | DB12141 | 827 | 971 | [
"DDInter1851",
"DDInter817"
] | Trazodone | Gilteritinib | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
827,
24,
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]
],
[
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],
[
112,
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[
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24,
485
],
[
485,
24,
971
]
],
[
[
827,
24,
823
],
[
823,
63,... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Trazodone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Trazodone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pen... |
DB00331 | DB09128 | 1,645 | 1,241 | [
"DDInter1164",
"DDInter231"
] | Metformin | Brexpiprazole | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
1645,
24,
1241
]
],
[
[
1645,
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],
[
1647,
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]
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[
[
1645,
24,
1296
],
[
1296,
63,
1241
]
],
[
[
1645,
63,
1179
],
[
11... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Metformin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acarbose"
],
[
... | Metformin may cause a minor interaction that can limit clinical effects when taken with Acarbose and Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Insul... |
DB00005 | DB11817 | 1,057 | 1,259 | [
"DDInter687",
"DDInter165"
] | Etanercept | Baricitinib | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
1057,
25,
1259
]
],
[
[
1057,
23,
1193
],
[
1193,
23,
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],
[
[
1057,
24,
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],
[
949,
24,
1259
]
],
[
[
1057,
25,
563
],
[
563,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Etanercept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc gl... | Etanercept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Clostridium teta... |
DB00489 | DB08895 | 17 | 976 | [
"DDInter1704",
"DDInter1825"
] | Sotalol | Tofacitinib | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
17,
24,
976
]
],
[
[
17,
25,
982
],
[
982,
63,
976
]
],
[
[
17,
24,
407
],
[
407,
63,
976
]
],
[
[
17,
63,
475
],
[
475,
24,
... | [
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Sotalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
],
[
"Ivosidenib",
... | Sotalol may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate inte... |
DB00026 | DB09330 | 1,184 | 985 | [
"DDInter94",
"DDInter1352"
] | Anakinra | Osimertinib | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
1184,
24,
985
]
],
[
[
1184,
24,
168
],
[
168,
23,
985
]
],
[
[
1184,
24,
134
],
[
134,
24,
985
]
],
[
[
1184,
24,
119
],
[
119,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbin... |
DB00480 | DB00539 | 1,668 | 11 | [
"DDInter1035",
"DDInter1837"
] | Lenalidomide | Toremifene | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Major | 2 | [
[
[
1668,
25,
11
]
],
[
[
1668,
6,
4973
],
[
4973,
45,
11
]
],
[
[
1668,
18,
20113
],
[
20113,
46,
11
]
],
[
[
1668,
21,
28646
],
[
28646,... | [
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
]
],
[
[
"Lenalidomide",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Torem... | Lenalidomide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Toremifene (Compound)
Lenalidomide (Compound) downregulates IER3 (Gene) and IER3 (Gene) is upregulated by Toremifene (Compound)
Lenalidomide (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disord... |
DB00539 | DB01324 | 11 | 178 | [
"DDInter1837",
"DDInter1490"
] | Toremifene | Polythiazide | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
11,
24,
178
]
],
[
[
11,
24,
674
],
[
674,
40,
178
]
],
[
[
11,
63,
323
],
[
323,
40,
178
]
],
[
[
11,
21,
28852
],
[
28852,
60,... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]... | Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Bendroflumethiazide and Bendroflumethiazide (Compou... |
DB00302 | DB09389 | 335 | 517 | [
"DDInter1844",
"DDInter1315"
] | Tranexamic acid | Norgestrel | Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986. | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Major | 2 | [
[
[
335,
25,
517
]
],
[
[
335,
25,
350
],
[
350,
25,
517
]
],
[
[
335,
21,
28661
],
[
28661,
60,
1130
],
[
1130,
23,
517
]
],
[
[
335,
... | [
[
[
"Tranexamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Norgestrel"
]
],
[
[
"Tranexamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carfilzomib"
],
[
"Carfilzomib",
... | Tranexamic acid may lead to a major life threatening interaction when taken with Carfilzomib and Carfilzomib may lead to a major life threatening interaction when taken with Norgestrel
Tranexamic acid (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Pioglita... |
DB01254 | DB11575 | 1,213 | 1,676 | [
"DDInter484",
"DDInter841"
] | Dasatinib | Grazoprevir | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common i... | Moderate | 1 | [
[
[
1213,
24,
1676
]
],
[
[
1213,
63,
723
],
[
723,
24,
1676
]
],
[
[
1213,
25,
868
],
[
868,
24,
1676
]
],
[
[
1213,
24,
1478
],
[
1478,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Grazoprevir"
]
],
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Grazoprevir
Dasatinib may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause... |
DB00349 | DB00372 | 902 | 999 | [
"DDInter401",
"DDInter1793"
] | Clobazam | Thiethylperazine | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Moderate | 1 | [
[
[
902,
24,
999
]
],
[
[
902,
23,
460
],
[
460,
62,
999
]
],
[
[
902,
24,
1614
],
[
1614,
63,
999
]
],
[
[
902,
40,
523
],
[
523,
6... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Clobazam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
],... | Clobazam may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate and Magnesium carbonate may cause a minor interaction that can limit clinical effects when taken with Thiethylperazine
Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Nabil... |
DB00227 | DB11967 | 1,463 | 710 | [
"DDInter1098",
"DDInter210"
] | Lovastatin | Binimetinib | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
1463,
24,
710
]
],
[
[
1463,
24,
1593
],
[
1593,
24,
710
]
],
[
[
1463,
24,
1619
],
[
1619,
63,
710
]
],
[
[
1463,
25,
760
],
[
760,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[
... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucapa... |
DB01115 | DB09065 | 336 | 760 | [
"DDInter1291",
"DDInter424"
] | Nifedipine | Cobicistat | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
336,
24,
760
]
],
[
[
336,
63,
1101
],
[
1101,
23,
760
]
],
[
[
336,
63,
723
],
[
723,
24,
760
]
],
[
[
336,
24,
761
],
[
761,
2... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepita... |
DB00398 | DB12141 | 79 | 971 | [
"DDInter1702",
"DDInter817"
] | Sorafenib | Gilteritinib | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
79,
24,
971
]
],
[
[
79,
23,
1135
],
[
1135,
23,
971
]
],
[
[
79,
24,
485
],
[
485,
24,
971
]
],
[
[
79,
24,
730
],
[
730,
63,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Sorafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Sorafenib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine... |
DB01619 | DB09128 | 830 | 1,241 | [
"DDInter1441",
"DDInter231"
] | Phenindamine | Brexpiprazole | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
830,
24,
1241
]
],
[
[
830,
24,
407
],
[
407,
63,
1241
]
],
[
[
830,
63,
543
],
[
543,
24,
1241
]
],
[
[
830,
1,
1219
],
[
1219,
... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamid... |
DB00861 | DB06822 | 914 | 802 | [
"DDInter551",
"DDInter1812"
] | Diflunisal | Tinzaparin | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Major | 2 | [
[
[
914,
25,
802
]
],
[
[
914,
24,
222
],
[
222,
24,
802
]
],
[
[
914,
24,
738
],
[
738,
63,
802
]
],
[
[
914,
63,
121
],
[
121,
24,... | [
[
[
"Diflunisal",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
]
],
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutrami... | Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Tinzaparin
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Nirap... |
DB00794 | DB08899 | 759 | 129 | [
"DDInter1521",
"DDInter649"
] | Primidone | Enzalutamide | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
759,
24,
129
]
],
[
[
759,
6,
8374
],
[
8374,
45,
129
]
],
[
[
759,
21,
28921
],
[
28921,
60,
129
]
],
[
[
759,
24,
112
],
[
112,
... | [
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Primidone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Primidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Primidone (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Enzalutamide (Compound)
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and ... |
DB01142 | DB01611 | 1,264 | 1,487 | [
"DDInter593",
"DDInter893"
] | Doxepin | Hydroxychloroquine | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
1264,
25,
1487
]
],
[
[
1264,
63,
1520
],
[
1520,
25,
1487
]
],
[
[
1264,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
1264,
21,
28658
],
[
... | [
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
"Primaqui... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Doxepin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Doxepin (Compound) caus... |
DB01259 | DB09381 | 392 | 192 | [
"DDInter1024",
"DDInter678"
] | Lapatinib | Esterified estrogens | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
392,
24,
192
]
],
[
[
392,
63,
752
],
[
752,
23,
192
]
],
[
[
392,
63,
1051
],
[
1051,
24,
192
]
],
[
[
392,
24,
913
],
[
913,
6... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],
... | Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Esterified estrogens
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimi... |
DB01285 | DB11627 | 708 | 1,367 | [
"DDInter445",
"DDInter860"
] | Corticotropin | Hepatitis B Vaccine (Recombinant) | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
708,
24,
1367
]
],
[
[
708,
63,
1648
],
[
1648,
24,
1367
]
],
[
[
708,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
708,
24,
259
],
[
259,
... | [
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Corticotropin may lead to a major life threatening interaction when taken with Cladr... |
DB00741 | DB00816 | 167 | 1,674 | [
"DDInter885",
"DDInter1346"
] | Hydrocortisone | Orciprenaline | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Minor | 0 | [
[
[
167,
23,
1674
]
],
[
[
167,
5,
11649
],
[
11649,
44,
1674
]
],
[
[
167,
7,
6858
],
[
6858,
46,
1674
]
],
[
[
167,
21,
28921
],
[
28921... | [
[
[
"Hydrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Orciprenaline"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) treats {v} (Disease)",
"asthma"
],
[
"asthma",
"{u} (Disease) is treated b... | Hydrocortisone (Compound) treats asthma (Disease) and asthma (Disease) is treated by Orciprenaline (Compound)
Hydrocortisone (Compound) upregulates LPL (Gene) and LPL (Gene) is upregulated by Orciprenaline (Compound)
Hydrocortisone (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orcip... |
DB00048 | DB06441 | 1,595 | 936 | [
"DDInter435",
"DDInter283"
] | Collagenase clostridium histolyticum | Cangrelor | Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ... | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Moderate | 1 | [
[
[
1595,
24,
936
]
],
[
[
1595,
24,
477
],
[
477,
24,
936
]
],
[
[
1595,
63,
1271
],
[
1271,
25,
936
]
],
[
[
1595,
24,
1167
],
[
1167,
... | [
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cangrelor"
]
],
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when ... | Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Cangrelor
Collagenase clostridium histolyticum may cause a moderate interaction that could exacer... |
DB00242 | DB12674 | 1,064 | 975 | [
"DDInter392",
"DDInter1105"
] | Cladribine | Lurbinectedin | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Major | 2 | [
[
[
1064,
25,
975
]
],
[
[
1064,
36,
1488
],
[
1488,
24,
975
]
],
[
[
1064,
24,
1613
],
[
1613,
24,
975
]
],
[
[
1064,
25,
372
],
[
372,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Cladribine",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",
"Fludarabin... | Cladribine (Compound) resembles Fludarabine (Compound) and Cladribine may lead to a major life threatening interaction when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Cladribine may cause a moderate interaction that could exacerba... |
DB00586 | DB00774 | 1,512 | 1,577 | [
"DDInter537",
"DDInter889"
] | Diclofenac | Hydroflumethiazide | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Moderate | 1 | [
[
[
1512,
24,
1577
]
],
[
[
1512,
24,
359
],
[
359,
40,
1577
]
],
[
[
1512,
63,
323
],
[
323,
40,
1577
]
],
[
[
1512,
24,
504
],
[
504,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorothiazide"
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Hydroflumethiazide (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Bendroflumethiazide and Bendroflumethiazide (Compound... |
DB00622 | DB12332 | 1,081 | 1,619 | [
"DDInter1287",
"DDInter1626"
] | Nicardipine | Rucaparib | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1081,
24,
1619
]
],
[
[
1081,
24,
259
],
[
259,
24,
1619
]
],
[
[
1081,
40,
84
],
[
84,
24,
1619
]
],
[
[
1081,
63,
1419
],
[
1419,
... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
[
... | Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Nicardipine (Compound) resembles Nisoldipine (Compound) and Nisoldipine may cause a moderate interaction that co... |
DB01174 | DB11569 | 697 | 1,093 | [
"DDInter1442",
"DDInter1003"
] | Phenobarbital | Ixekizumab | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Moderate | 1 | [
[
[
697,
24,
1093
]
],
[
[
697,
62,
608
],
[
608,
24,
1093
]
],
[
[
697,
63,
134
],
[
134,
24,
1093
]
],
[
[
697,
24,
1683
],
[
1683,
... | [
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
]
],
[
[
"Phenobarbital",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lidocaine"
],
[... | Phenobarbital may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab
Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vin... |
DB00222 | DB00991 | 245 | 97 | [
"DDInter825",
"DDInter1358"
] | Glimepiride | Oxaprozin | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
[
245,
24,
97
]
],
[
[
245,
24,
939
],
[
939,
40,
97
]
],
[
[
245,
24,
362
],
[
362,
1,
97
]
],
[
[
245,
24,
1274
],
[
1274,
24,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Oxaprozin (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Oxaprozin (Compou... |
DB00771 | DB00934 | 262 | 413 | [
"DDInter397",
"DDInter1124"
] | Clidinium | Maprotiline | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Moderate | 1 | [
[
[
262,
24,
413
]
],
[
[
262,
63,
1302
],
[
1302,
40,
413
]
],
[
[
262,
6,
7992
],
[
7992,
45,
413
]
],
[
[
262,
24,
832
],
[
832,
... | [
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
]
],
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
],
[
... | Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Maprotiline (Compound)
Clidinium (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Maprotiline (Compound)
Clidinium may cause a moderate interaction that could exacerba... |
DB01235 | DB06317 | 1,191 | 1,626 | [
"DDInter1054",
"DDInter630"
] | Levodopa | Elotuzumab | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
1191,
24,
1626
]
],
[
[
1191,
63,
973
],
[
973,
24,
1626
]
],
[
[
1191,
24,
310
],
[
310,
63,
1626
]
],
[
[
1191,
24,
1487
],
[
1487,
... | [
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitax... |
DB00065 | DB10989 | 581 | 496 | [
"DDInter923",
"DDInter858"
] | Infliximab | Hepatitis A Vaccine | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
581,
24,
496
]
],
[
[
581,
25,
1093
],
[
1093,
63,
496
]
],
[
[
581,
25,
4
],
[
4,
24,
496
]
],
[
[
581,
64,
1560
],
[
1560,
24,... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixekizumab"
],
[
"I... | Infliximab may lead to a major life threatening interaction when taken with Ixekizumab and Ixekizumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Infliximab may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine ... |
DB00618 | DB01060 | 1,572 | 319 | [
"DDInter498",
"DDInter83"
] | Demeclocycline | Amoxicillin | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin. Amoxicillin was granted FDA approval on 18 January 1974. | Moderate | 1 | [
[
[
1572,
24,
319
]
],
[
[
1572,
63,
1249
],
[
1249,
40,
319
]
],
[
[
1572,
24,
950
],
[
950,
1,
319
]
],
[
[
1572,
24,
1138
],
[
1138,
... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amoxicillin"
]
],
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nafcillin"
],
... | Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin (Compound) resembles Amoxicillin (Compound)
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Cloxacillin and Cloxacillin (Compound) resembles Amoxicillin (... |
DB06788 | DB08903 | 1,616 | 996 | [
"DDInter864",
"DDInter170"
] | Histrelin | Bedaquiline | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Major | 2 | [
[
[
1616,
25,
996
]
],
[
[
1616,
62,
112
],
[
112,
23,
996
]
],
[
[
1616,
63,
355
],
[
355,
24,
996
]
],
[
[
1616,
24,
144
],
[
144,
... | [
[
[
"Histrelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
]
],
[
[
"Histrelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Histrelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Bedaquiline
Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and Lactul... |
DB01035 | DB11767 | 1,401 | 1,583 | [
"DDInter1524",
"DDInter1643"
] | Procainamide | Sarilumab | A derivative of procaine with less CNS action. | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
1401,
24,
1583
]
],
[
[
1401,
24,
4
],
[
4,
24,
1583
]
],
[
[
1401,
63,
58
],
[
58,
24,
1583
]
],
[
[
1401,
24,
270
],
[
270,
63... | [
[
[
"Procainamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Procainamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinat... | Procainamide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Procainamide may cause a moderate interaction that could exacerbate diseases when... |
DB00087 | DB11627 | 599 | 1,367 | [
"DDInter41",
"DDInter860"
] | Alemtuzumab | Hepatitis B Vaccine (Recombinant) | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
599,
24,
1367
]
],
[
[
599,
24,
1083
],
[
1083,
24,
1367
]
],
[
[
599,
63,
1648
],
[
1648,
24,
1367
]
],
[
[
599,
25,
1064
],
[
1064,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tr... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when tak... |
DB00238 | DB06626 | 188 | 263 | [
"DDInter1285",
"DDInter147"
] | Nevirapine | Axitinib | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Moderate | 1 | [
[
[
188,
24,
263
]
],
[
[
188,
24,
379
],
[
379,
23,
263
]
],
[
[
188,
24,
322
],
[
322,
24,
263
]
],
[
[
188,
24,
1593
],
[
1593,
6... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Axitinib"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
],
[
... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole may cause a minor interaction that can limit clinical effects when taken with Axitinib
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubic... |
DB00224 | DB01309 | 215 | 1,254 | [
"DDInter917",
"DDInter933"
] | Indinavir | Insulin glulisine | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
215,
24,
1254
]
],
[
[
215,
24,
1424
],
[
1424,
24,
1254
]
],
[
[
215,
63,
168
],
[
168,
24,
1254
]
],
[
[
215,
24,
1450
],
[
1450,
... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
[
... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezo... |
DB00857 | DB04861 | 1,387 | 1,592 | [
"DDInter1768",
"DDInter1271"
] | Terbinafine | Nebivolol | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
1387,
24,
1592
]
],
[
[
1387,
7,
3576
],
[
3576,
45,
1592
]
],
[
[
1387,
6,
12523
],
[
12523,
45,
1592
]
],
[
[
1387,
21,
28762
],
[
2... | [
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Terbinafine",
"{u} (Compound) upregulates {v} (Gene)",
"ADRB2"
],
[
"ADRB2",
"{u} (Gene) is bound by {v} (Compou... | Terbinafine (Compound) upregulates ADRB2 (Gene) and ADRB2 (Gene) is bound by Nebivolol (Compound)
Terbinafine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Nebivolol (Compound)
Terbinafine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Terbinafine ma... |
DB00026 | DB00401 | 1,184 | 84 | [
"DDInter94",
"DDInter1298"
] | Anakinra | Nisoldipine | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Moderate | 1 | [
[
[
1184,
24,
84
]
],
[
[
1184,
24,
854
],
[
854,
1,
84
]
],
[
[
1184,
24,
376
],
[
376,
40,
84
]
],
[
[
1184,
24,
1031
],
[
1031,
2... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nisoldipine"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nimodipine"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Nimodipine and Nimodipine (Compound) resembles Nisoldipine (Compound)
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Nisoldipine (Compound)
An... |
DB01181 | DB14509 | 1,532 | 1,399 | [
"DDInter906",
"DDInter1081"
] | Ifosfamide | Lithium carbonate | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
1532,
24,
1399
]
],
[
[
1532,
63,
589
],
[
589,
23,
1399
]
],
[
[
1532,
24,
820
],
[
820,
24,
1399
]
],
[
[
1532,
63,
1555
],
[
1555,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
],
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Al... |
DB00615 | DB06626 | 690 | 263 | [
"DDInter1589",
"DDInter147"
] | Rifabutin | Axitinib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Major | 2 | [
[
[
690,
25,
263
]
],
[
[
690,
24,
392
],
[
392,
24,
263
]
],
[
[
690,
25,
1593
],
[
1593,
63,
263
]
],
[
[
690,
24,
214
],
[
214,
6... | [
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Axitinib"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
[
"Lapatinib",
... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Axitinib
Rifabutin may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a mode... |
DB00761 | DB01036 | 1,621 | 211 | [
"DDInter1497",
"DDInter1832"
] | Potassium chloride | Tolterodine | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Major | 2 | [
[
[
1621,
25,
211
]
],
[
[
1621,
25,
358
],
[
358,
40,
211
]
],
[
[
1621,
64,
494
],
[
494,
40,
211
]
],
[
[
1621,
64,
128
],
[
128,
... | [
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tolterodine"
]
],
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Orphenadrine"
],
[
"Orphen... | Potassium chloride may lead to a major life threatening interaction when taken with Orphenadrine and Orphenadrine (Compound) resembles Tolterodine (Compound)
Potassium chloride may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) resembles Tolterodine (Compound)
Pota... |
DB00285 | DB00366 | 1,100 | 1,594 | [
"DDInter1927",
"DDInter600"
] | Venlafaxine | Doxylamine | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Moderate | 1 | [
[
[
1100,
24,
1594
]
],
[
[
1100,
25,
11
],
[
11,
1,
1594
]
],
[
[
1100,
24,
662
],
[
662,
63,
1594
]
],
[
[
1100,
25,
1264
],
[
1264,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
]
],
[
[
"Venlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
],
[
"Toremife... | Venlafaxine may lead to a major life threatening interaction when taken with Toremifene and Toremifene (Compound) resembles Doxylamine (Compound)
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacer... |
DB01233 | DB04855 | 1,311 | 540 | [
"DDInter1197",
"DDInter602"
] | Metoclopramide | Dronedarone | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Moderate | 1 | [
[
[
1311,
24,
540
]
],
[
[
1311,
6,
12523
],
[
12523,
45,
540
]
],
[
[
1311,
21,
28787
],
[
28787,
60,
540
]
],
[
[
1311,
63,
629
],
[
629... | [
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
]
],
[
[
"Metoclopramide",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Co... | Metoclopramide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dronedarone (Compound)
Metoclopramide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Dronedarone (Compound)
Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Sir... |
DB01166 | DB06228 | 477 | 792 | [
"DDInter379",
"DDInter1609"
] | Cilostazol | Rivaroxaban | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
477,
25,
792
]
],
[
[
477,
6,
7524
],
[
7524,
45,
792
]
],
[
[
477,
18,
5901
],
[
5901,
57,
792
]
],
[
[
477,
21,
28703
],
[
28703,
... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Cilostazol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
"Rivaro... | Cilostazol (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Rivaroxaban (Compound)
Cilostazol (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Rivaroxaban (Compound)
Cilostazol (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Cil... |
DB00286 | DB08912 | 380 | 1,040 | [
"DDInter439",
"DDInter462"
] | Conjugated estrogens | Dabrafenib | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
380,
24,
1040
]
],
[
[
380,
6,
13478
],
[
13478,
45,
1040
]
],
[
[
380,
7,
8587
],
[
8587,
57,
1040
]
],
[
[
380,
6,
12977
],
[
12977,... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Conjugated estrogens",
"{u} (Compound) binds {v} (Gene)",
"SLCO1B3"
],
[
"SLCO1B3",
"{u} (Gene) is bou... | Conjugated estrogens (Compound) binds SLCO1B3 (Gene) and SLCO1B3 (Gene) is bound by Dabrafenib (Compound)
Conjugated estrogens (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is downregulated by Dabrafenib (Compound)
Conjugated estrogens (Compound) binds SLCO4A1 (Gene) and SLCO4A1 (Gene) is downregulated by Dabrafen... |
DB09061 | DB09570 | 1,627 | 1,480 | [
"DDInter284",
"DDInter1002"
] | Cannabidiol | Ixazomib | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
1627,
24,
1480
]
],
[
[
1627,
63,
268
],
[
268,
24,
1480
]
],
[
[
1627,
24,
214
],
[
214,
63,
1480
]
],
[
[
1627,
62,
1593
],
[
1593,
... | [
[
[
"Cannabidiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Cannabidiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
... | Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00556 | DB09082 | 1,262 | 659 | [
"DDInter1429",
"DDInter1934"
] | Perflutren | Vilanterol | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1262,
24,
659
]
],
[
[
1262,
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[
927,
63,
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[
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[
1069,
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[
[
1262,
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485
],
[
485,
... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[
... | Perflutren may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Perflutren may lead to a major life threatening interaction when taken with Vandetanib and Vandetanib may caus... |
DB09034 | DB09073 | 1,313 | 951 | [
"DDInter1733",
"DDInter1379"
] | Suvorexant | Palbociclib | Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1313,
24,
951
]
],
[
[
1313,
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1476
],
[
1476,
63,
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[
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1313,
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[
467,
24,
951
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],
[
[
1313,
25,
283
],
[
283,
... | [
[
[
"Suvorexant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Suvorexant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Suvorexant may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Suvorexant may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simv... |
DB09074 | DB11691 | 1,362 | 1,499 | [
"DDInter1327",
"DDInter1258"
] | Olaparib | Naldemedine | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Moderate | 1 | [
[
[
1362,
24,
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[
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[
307,
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[
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932
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[
932,
24,
1499
]
],
[
[
1362,
64,
723
],
[
723,
... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naldemedine"
]
],
[
[
"Olaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Modafinil"
],
[
"Modafinil",
... | Olaparib may lead to a major life threatening interaction when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Naldemedine
Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Mifepristone and Mifepristone may cause a m... |
DB01227 | DB06699 | 1,301 | 774 | [
"DDInter1043",
"DDInter493"
] | Levacetylmethadol | Degarelix | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Major | 2 | [
[
[
1301,
25,
774
]
],
[
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1301,
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[
521,
1,
774
]
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[
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1301,
62,
112
],
[
112,
23,
774
]
],
[
[
1301,
75,
888
],
[
888,
... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Degarelix"
]
],
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Goserelin"
],
[
"Goserelin",
... | Levacetylmethadol may lead to a major life threatening interaction when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Levacetylmethadol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limi... |
DB00280 | DB06372 | 494 | 259 | [
"DDInter575",
"DDInter1594"
] | Disopyramide | Rilonacept | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
494,
24,
259
]
],
[
[
494,
25,
1619
],
[
1619,
63,
259
]
],
[
[
494,
24,
1573
],
[
1573,
24,
259
]
],
[
[
494,
25,
478
],
[
478,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rucaparib"
],
[
"Rucapar... | Disopyramide may lead to a major life threatening interaction when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may caus... |
DB00486 | DB06077 | 1,614 | 879 | [
"DDInter1253",
"DDInter1102"
] | Nabilone | Lumateperone | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
1614,
24,
879
]
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[
[
1614,
24,
407
],
[
407,
63,
879
]
],
[
[
1614,
24,
537
],
[
537,
24,
879
]
],
[
[
1614,
63,
999
],
[
999,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
"Op... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause... |
DB00014 | DB08903 | 521 | 996 | [
"DDInter839",
"DDInter170"
] | Goserelin | Bedaquiline | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Major | 2 | [
[
[
521,
25,
996
]
],
[
[
521,
21,
29282
],
[
29282,
60,
996
]
],
[
[
521,
23,
112
],
[
112,
23,
996
]
],
[
[
521,
24,
355
],
[
355,
... | [
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
]
],
[
[
"Goserelin",
"{u} (Compound) causes {v} (Side Effect)",
"Arrhythmia"
],
[
"Arrhythmia",
"{u} (Side Effect) is caused by {v} (Com... | Goserelin (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Bedaquiline (Compound)
Goserelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Beda... |
DB00544 | DB01005 | 970 | 995 | [
"DDInter757",
"DDInter894"
] | Fluorouracil | Hydroxyurea | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Moderate | 1 | [
[
[
970,
24,
995
]
],
[
[
970,
5,
11629
],
[
11629,
44,
995
]
],
[
[
970,
21,
29429
],
[
29429,
60,
995
]
],
[
[
970,
23,
1299
],
[
1299,
... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyurea"
]
],
[
[
"Fluorouracil",
"{u} (Compound) treats {v} (Disease)",
"head and neck cancer"
],
[
"head and neck cancer",
"{u... | Fluorouracil (Compound) treats head and neck cancer (Disease) and head and neck cancer (Disease) is treated by Hydroxyurea (Compound)
Fluorouracil (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Hydroxyurea (Compound)
Fluorouracil may cause a minor interaction that can lim... |
DB00633 | DB11130 | 614 | 407 | [
"DDInter520",
"DDInter1344"
] | Dexmedetomidine | Opium | An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
614,
24,
407
]
],
[
[
614,
24,
662
],
[
662,
24,
407
]
],
[
[
614,
63,
1233
],
[
1233,
24,
407
]
],
[
[
614,
24,
1609
],
[
1609,
... | [
[
[
"Dexmedetomidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Dexmedetomidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Dexmedetomidine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Dexmedetomidine may cause a moderate interaction that could exacerbate diseases when taken with Triprolidi... |
DB00361 | DB00582 | 134 | 1,622 | [
"DDInter1939",
"DDInter1946"
] | Vinorelbine | Voriconazole | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Major | 2 | [
[
[
134,
25,
1622
]
],
[
[
134,
6,
8374
],
[
8374,
45,
1622
]
],
[
[
134,
21,
28957
],
[
28957,
60,
1622
]
],
[
[
134,
24,
112
],
[
112,
... | [
[
[
"Vinorelbine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voriconazole"
]
],
[
[
"Vinorelbine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vor... | Vinorelbine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Voriconazole (Compound)
Vinorelbine (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Voriconazole (Compound)
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Metronidaz... |
DB01234 | DB11057 | 1,220 | 720 | [
"DDInter513",
"DDInter1223"
] | Dexamethasone | Mineral oil | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
1220,
24,
720
]
],
[
[
1220,
25,
927
],
[
927,
63,
720
]
],
[
[
1220,
1,
175
],
[
175,
24,
720
]
],
[
[
1220,
24,
1151
],
[
1151,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"En... | Dexamethasone may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Dexamethasone (Compound) resembles Triamcinolone (Compound) and Triamcinolone may cause a moderate interaction that could... |
DB00434 | DB00557 | 13 | 252 | [
"DDInter459",
"DDInter895"
] | Cyproheptadine | Hydroxyzine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Moderate | 1 | [
[
[
13,
24,
252
]
],
[
[
13,
24,
851
],
[
851,
1,
252
]
],
[
[
13,
24,
623
],
[
623,
40,
252
]
],
[
[
13,
40,
465
],
[
465,
1,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
],... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Hydroxyzine (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Hydroxyzine (... |
DB00759 | DB05528 | 1,620 | 1,070 | [
"DDInter1783",
"DDInter1228"
] | Tetracycline | Mipomersen | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
1620,
25,
1070
]
],
[
[
1620,
25,
1517
],
[
1517,
25,
1070
]
],
[
[
1620,
24,
384
],
[
384,
64,
1070
]
],
[
[
1620,
1,
1572
],
[
1572,... | [
[
[
"Tetracycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Tetracycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isotretinoin"
],
[
"Isotretinoin",
... | Tetracycline may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin may lead to a major life threatening interaction when taken with Mipomersen
Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may lead to a maj... |
DB00603 | DB09098 | 303 | 98 | [
"DDInter1137",
"DDInter1700"
] | Medroxyprogesterone acetate | Somatrem | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
303,
24,
98
]
],
[
[
303,
24,
1671
],
[
1671,
24,
98
]
],
[
[
303,
24,
159
],
[
159,
63,
98
]
],
[
[
303,
25,
34
],
[
34,
24,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin and Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases whe... |
DB00861 | DB01082 | 914 | 1,448 | [
"DDInter551",
"DDInter1713"
] | Diflunisal | Streptomycin | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
914,
24,
1448
]
],
[
[
914,
6,
10612
],
[
10612,
45,
1448
]
],
[
[
914,
21,
29327
],
[
29327,
60,
1448
]
],
[
[
914,
24,
1272
],
[
127... | [
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Diflunisal",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound by {v} (Compoun... | Diflunisal (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Streptomycin (Compound)
Diflunisal (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Streptomycin (Compound)
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Flucy... |
DB00820 | DB09112 | 402 | 1,455 | [
"DDInter1736",
"DDInter1306"
] | Tadalafil | Nitrous acid | Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibito... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
402,
24,
1455
]
],
[
[
402,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
402,
23,
885
],
[
885,
24,
1455
]
],
[
[
402,
62,
1214
],
[
1214,
... | [
[
[
"Tadalafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Tadalafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
[... | Tadalafil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Tadalafil may cause a minor interaction that can limit clinical effects when taken with Epoprostenol and ... |
DB00023 | DB00367 | 305 | 566 | [
"DDInter127",
"DDInter1061"
] | Asparaginase Escherichia coli | Levonorgestrel | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Moderate | 1 | [
[
[
305,
24,
566
]
],
[
[
305,
24,
873
],
[
873,
40,
566
]
],
[
[
305,
24,
1197
],
[
1197,
1,
566
]
],
[
[
305,
24,
1130
],
[
1130,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonorgestrel"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wit... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Norgestimate and Norgestimate (Compound) resembles Levonorgestrel (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and Nore... |
DB00222 | DB01276 | 245 | 123 | [
"DDInter825",
"DDInter706"
] | Glimepiride | Exenatide | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
245,
24,
123
]
],
[
[
245,
23,
1103
],
[
1103,
23,
123
]
],
[
[
245,
24,
532
],
[
532,
24,
123
]
],
[
[
245,
24,
1518
],
[
1518,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Glimepiride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
[
... | Glimepiride may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Exenatide
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine and Dobutamin... |
DB00408 | DB01409 | 1,408 | 1,415 | [
"DDInter1099",
"DDInter1815"
] | Loxapine | Tiotropium | An antipsychotic agent used in schizophrenia. [PubChem] | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
1408,
24,
1415
]
],
[
[
1408,
6,
4304
],
[
4304,
45,
1415
]
],
[
[
1408,
21,
28880
],
[
28880,
60,
1415
]
],
[
[
1408,
63,
1594
],
[
1... | [
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Loxapine",
"{u} (Compound) binds {v} (Gene)",
"CHRM2"
],
[
"CHRM2",
"{u} (Gene) is bound by {v} (Compound)",
... | Loxapine (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Tiotropium (Compound)
Loxapine (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Tiotropium (Compound)
Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine... |
DB00719 | DB00765 | 1,219 | 1,266 | [
"DDInter149",
"DDInter1205"
] | Azatadine | Metyrosine | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed) | Moderate | 1 | [
[
[
1219,
24,
1266
]
],
[
[
1219,
24,
662
],
[
662,
24,
1266
]
],
[
[
1219,
24,
401
],
[
401,
63,
1266
]
],
[
[
1219,
40,
830
],
[
830,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metyrosine"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Metyrosine
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and ... |
DB00738 | DB01028 | 485 | 1,332 | [
"DDInter1420",
"DDInter1179"
] | Pentamidine | Methoxyflurane | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular... | Moderate | 1 | [
[
[
485,
24,
1332
]
],
[
[
485,
6,
7950
],
[
7950,
45,
1332
]
],
[
[
485,
24,
50
],
[
50,
24,
1332
]
],
[
[
485,
24,
123
],
[
123,
6... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methoxyflurane"
]
],
[
[
"Pentamidine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compo... | Pentamidine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Methoxyflurane (Compound)
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Pe... |
DB09133 | DB14598 | 1,527 | 183 | [
"DDInter965",
"DDInter619"
] | Iothalamic acid | Edetate calcium disodium anhydrous | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Edetate calcium disodium is a metal ion chelator used to reduce blood concentrations and depot stores of lead from the body. It is on the World Health Organization Model List of Essential Medicines. Edetate calcium disodium was granted FDA approval on 16 July 1953. | Major | 2 | [
[
[
1527,
25,
183
]
],
[
[
1527,
64,
372
],
[
372,
24,
183
]
],
[
[
1527,
64,
789
],
[
789,
24,
372
],
[
372,
24,
183
]
],
[
[
1527,
... | [
[
[
"Iothalamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edetate calcium disodium anhydrous"
]
],
[
[
"Iothalamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clofarabine"
],
... | Iothalamic acid may lead to a major life threatening interaction when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Edetate calcium disodium anhydrous
Iothalamic acid may lead to a major life threatening interaction when taken with Foscarnet and F... |
DB01390 | DB08901 | 1,117 | 1,468 | [
"DDInter1683",
"DDInter1492"
] | Sodium bicarbonate | Ponatinib | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Minor | 0 | [
[
[
1117,
23,
1468
]
],
[
[
1117,
24,
478
],
[
478,
24,
1468
]
],
[
[
1117,
21,
28695
],
[
28695,
60,
1468
]
],
[
[
1117,
62,
1194
],
[
11... | [
[
[
"Sodium bicarbonate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ponatinib"
]
],
[
[
"Sodium bicarbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
... | Sodium bicarbonate may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Sodium bicarbonate (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Ponatin... |
DB00491 | DB00741 | 127 | 167 | [
"DDInter1217",
"DDInter885"
] | Miglitol | Hydrocortisone | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
127,
24,
167
]
],
[
[
127,
24,
1220
],
[
1220,
40,
167
]
],
[
[
127,
24,
870
],
[
870,
1,
167
]
],
[
[
127,
63,
251
],
[
251,
40... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Hydroc... |
DB00994 | DB01028 | 361 | 1,332 | [
"DDInter1277",
"DDInter1179"
] | Neomycin | Methoxyflurane | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular... | Moderate | 1 | [
[
[
361,
24,
1332
]
],
[
[
361,
24,
1448
],
[
1448,
63,
1332
]
],
[
[
361,
63,
589
],
[
589,
24,
1332
]
],
[
[
361,
25,
1527
],
[
1527,
... | [
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methoxyflurane"
]
],
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
],
[
... | Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin and Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cis... |
DB00586 | DB09135 | 1,512 | 1,211 | [
"DDInter537",
"DDInter967"
] | Diclofenac | Ioxilan | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Major | 2 | [
[
[
1512,
25,
1211
]
],
[
[
1512,
63,
17
],
[
17,
24,
1211
]
],
[
[
1512,
24,
863
],
[
863,
24,
1211
]
],
[
[
1512,
24,
242
],
[
242,
... | [
[
[
"Diclofenac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioxilan"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
],
[
"Sotalol",
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Amiloride and Amiloride may ca... |
DB00627 | DB01309 | 265 | 1,254 | [
"DDInter1286",
"DDInter933"
] | Niacin | Insulin glulisine | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
265,
24,
1254
]
],
[
[
265,
63,
1645
],
[
1645,
24,
1254
]
],
[
[
265,
24,
170
],
[
170,
24,
1254
]
],
[
[
265,
24,
1450
],
[
1450,
... | [
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
],
[
... | Niacin may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Niacin may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitaglip... |
DB00812 | DB11581 | 998 | 1,456 | [
"DDInter1451",
"DDInter1926"
] | Phenylbutazone | Venetoclax | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
998,
24,
1456
]
],
[
[
998,
24,
1135
],
[
1135,
23,
1456
]
],
[
[
998,
24,
1476
],
[
1476,
63,
1456
]
],
[
[
998,
24,
1683
],
[
1683,
... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Br... |
DB00916 | DB01208 | 112 | 945 | [
"DDInter1202",
"DDInter1705"
] | Metronidazole | Sparfloxacin | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Minor | 0 | [
[
[
112,
23,
945
]
],
[
[
112,
23,
739
],
[
739,
1,
945
]
],
[
[
112,
62,
1176
],
[
1176,
1,
945
]
],
[
[
112,
21,
28787
],
[
28787,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxac... |
DB00683 | DB14568 | 1,382 | 982 | [
"DDInter1212",
"DDInter1000"
] | Midazolam | Ivosidenib | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
1382,
24,
982
]
],
[
[
1382,
63,
1101
],
[
1101,
23,
982
]
],
[
[
1382,
24,
770
],
[
770,
24,
982
]
],
[
[
1382,
23,
286
],
[
286,
... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomi... |
DB00881 | DB08880 | 954 | 1,510 | [
"DDInter1554",
"DDInter1771"
] | Quinapril | Teriflunomide | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
954,
25,
1510
]
],
[
[
954,
63,
1144
],
[
1144,
24,
1510
]
],
[
[
954,
24,
1450
],
[
1450,
63,
1510
]
],
[
[
954,
24,
473
],
[
473,
... | [
[
[
"Quinapril",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Quinapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
[
"Nateglin... | Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and ... |
DB00365 | DB01041 | 839 | 770 | [
"DDInter842",
"DDInter1789"
] | Grepafloxacin | Thalidomide | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
839,
24,
770
]
],
[
[
839,
25,
609
],
[
609,
63,
770
]
],
[
[
839,
64,
521
],
[
521,
24,
770
]
],
[
[
839,
25,
79
],
[
79,
24,
... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
... | Grepafloxacin may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Grepafloxacin may lead to a major life threatening interaction when taken with Goserelin and Goserelin may cause a ... |
DB00035 | DB00394 | 1,314 | 218 | [
"DDInter507",
"DDInter168"
] | Desmopressin | Beclomethasone dipropionate | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Beclomethasone dipropionate is a second-generation synthetic corticosteroid and diester of beclomethasone, which is structurally similar to [dexamethasone]. It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP) which acts on the glucocorticoid receptor to mediates its therapeutic action. Bec... | Major | 2 | [
[
[
1314,
25,
218
]
],
[
[
1314,
25,
1220
],
[
1220,
40,
218
]
],
[
[
1314,
21,
28719
],
[
28719,
60,
218
]
],
[
[
1314,
24,
1148
],
[
114... | [
[
[
"Desmopressin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Beclomethasone dipropionate"
]
],
[
[
"Desmopressin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
],
[
"D... | Desmopressin may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone (Compound) resembles Beclomethasone dipropionate (Compound)
Desmopressin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Beclomethasone dipropionate (Compound)
Desmopressin may cause a ... |
DB08916 | DB11986 | 26 | 484 | [
"DDInter32",
"DDInter648"
] | Afatinib | Entrectinib | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
26,
24,
484
]
],
[
[
26,
24,
466
],
[
466,
62,
484
]
],
[
[
26,
63,
322
],
[
322,
24,
484
]
],
[
[
26,
24,
1320
],
[
1320,
24,
... | [
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Afatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubi... |
DB00604 | DB06663 | 1,425 | 1,154 | [
"DDInter385",
"DDInter1398"
] | Cisapride | Pasireotide | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
1425,
25,
1154
]
],
[
[
1425,
23,
112
],
[
112,
23,
1154
]
],
[
[
1425,
25,
1662
],
[
1662,
63,
1154
]
],
[
[
1425,
24,
1017
],
[
1017... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Cisapride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Cisapride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pasireotide
Cisapride may lead to a major life threatening interaction when taken with Picosulfuric acid and Picosulfuric ... |
DB00620 | DB01390 | 175 | 1,117 | [
"DDInter1855",
"DDInter1683"
] | Triamcinolone | Sodium bicarbonate | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Minor | 0 | [
[
[
175,
23,
1117
]
],
[
[
175,
21,
29093
],
[
29093,
60,
1117
]
],
[
[
175,
40,
1220
],
[
1220,
23,
1117
]
],
[
[
175,
62,
1018
],
[
1018... | [
[
[
"Triamcinolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Triamcinolone",
"{u} (Compound) causes {v} (Side Effect)",
"Fatigue"
],
[
"Fatigue",
"{u} (Side Effect)... | Triamcinolone (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Sodium bicarbonate (Compound)
Triamcinolone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbonate
Triamcinolone may caus... |
DB00916 | DB06317 | 112 | 1,626 | [
"DDInter1202",
"DDInter630"
] | Metronidazole | Elotuzumab | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
112,
24,
1626
]
],
[
[
112,
24,
973
],
[
973,
24,
1626
]
],
[
[
112,
63,
1463
],
[
1463,
24,
1626
]
],
[
[
112,
24,
310
],
[
310,
... | [
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
... | Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and ... |
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