drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00674 | DB01166 | 1,516 | 477 | [
"DDInter802",
"DDInter379"
] | Galantamine | Cilostazol | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
1516,
24,
477
]
],
[
[
1516,
6,
8374
],
[
8374,
45,
477
]
],
[
[
1516,
21,
28919
],
[
28919,
60,
477
]
],
[
[
1516,
24,
112
],
[
112,
... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Galantamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Galantamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Galantamine (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Cilostazol (Compound)
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole an... |
DB00757 | DB09082 | 1,166 | 659 | [
"DDInter581",
"DDInter1934"
] | Dolasetron | Vilanterol | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1166,
24,
659
]
],
[
[
1166,
64,
1570
],
[
1570,
24,
659
]
],
[
[
1166,
25,
927
],
[
927,
63,
659
]
],
[
[
1166,
25,
1069
],
[
1069,
... | [
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azithromycin"
],
[
"Azithrom... | Dolasetron may lead to a major life threatening interaction when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Dolasetron may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderat... |
DB00041 | DB00876 | 1,648 | 1,414 | [
"DDInter38",
"DDInter658"
] | Aldesleukin | Eprosartan | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced. | Moderate | 1 | [
[
[
1648,
24,
1414
]
],
[
[
1648,
24,
240
],
[
240,
40,
1414
]
],
[
[
1648,
24,
1264
],
[
1264,
63,
1414
]
],
[
[
1648,
24,
175
],
[
175,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eprosartan"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Losartan"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) resembles Eprosartan (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerb... |
DB00818 | DB01246 | 898 | 820 | [
"DDInter1538",
"DDInter45"
] | Propofol | Alimemazine | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
898,
24,
820
]
],
[
[
898,
24,
401
],
[
401,
24,
820
]
],
[
[
898,
6,
8374
],
[
8374,
45,
820
]
],
[
[
898,
21,
29339
],
[
29339,
... | [
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Propofol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Propofol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Propofol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Alimemazine (Compound)
Propofol (Compou... |
DB00857 | DB01096 | 1,387 | 678 | [
"DDInter1768",
"DDInter1356"
] | Terbinafine | Oxamniquine | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Ex... | Moderate | 1 | [
[
[
1387,
24,
678
]
],
[
[
1387,
6,
12523
],
[
12523,
45,
678
]
],
[
[
1387,
23,
211
],
[
211,
23,
678
]
],
[
[
1387,
62,
479
],
[
479,
... | [
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxamniquine"
]
],
[
[
"Terbinafine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound... | Terbinafine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Oxamniquine (Compound)
Terbinafine may cause a minor interaction that can limit clinical effects when taken with Tolterodine and Tolterodine may cause a minor interaction that can limit clinical effects when taken with Oxamniquine
Terbinafine may ... |
DB00204 | DB11837 | 228 | 1,297 | [
"DDInter580",
"DDInter1351"
] | Dofetilide | Osilodrostat | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
228,
25,
1297
]
],
[
[
228,
23,
112
],
[
112,
23,
1297
]
],
[
[
228,
24,
578
],
[
578,
24,
1297
]
],
[
[
228,
25,
401
],
[
401,
... | [
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Dofetilide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Dofetilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Dofetilide may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ti... |
DB09074 | DB10795 | 1,362 | 221 | [
"DDInter1327",
"DDInter1486"
] | Olaparib | Poliovirus type 1 antigen (formaldehyde inactivated) | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
1362,
24,
221
]
],
[
[
1362,
63,
36
],
[
36,
24,
221
]
],
[
[
1362,
64,
581
],
[
581,
24,
221
]
],
[
[
1362,
25,
351
],
[
351,
6... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Olaparib may lead to a major life threatening interaction when taken with In... |
DB01599 | DB08875 | 1,232 | 1,618 | [
"DDInter1523",
"DDInter262"
] | Probucol | Cabozantinib | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1232,
25,
1618
]
],
[
[
1232,
62,
112
],
[
112,
23,
1618
]
],
[
[
1232,
24,
1662
],
[
1662,
63,
1618
]
],
[
[
1232,
63,
480
],
[
480,
... | [
[
[
"Probucol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Probucol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazo... | Probucol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Probucol may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and... |
DB05773 | DB06209 | 1,047 | 256 | [
"DDInter1848",
"DDInter1508"
] | Trastuzumab emtansine | Prasugrel | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Major | 2 | [
[
[
1047,
25,
256
]
],
[
[
1047,
63,
901
],
[
901,
24,
256
]
],
[
[
1047,
24,
1427
],
[
1427,
63,
256
]
],
[
[
1047,
64,
1479
],
[
1479,
... | [
[
[
"Trastuzumab emtansine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
]
],
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
],
... | Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran may cause a moderate interaction that could exacerbate diseases when taken with Prasugrel
Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB09498 | DB11767 | 810 | 1,583 | [
"DDInter1715",
"DDInter1643"
] | Strontium chloride Sr-89 | Sarilumab | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
810,
24,
1583
]
],
[
[
810,
63,
1186
],
[
1186,
24,
1583
]
],
[
[
810,
24,
738
],
[
738,
63,
1583
]
],
[
[
810,
24,
1456
],
[
1456,
... | [
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 dichloride and Radium Ra 223 dichloride may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Strontium chloride Sr-89 may cause a moderate interaction that could ex... |
DB00647 | DB01041 | 675 | 770 | [
"DDInter528",
"DDInter1789"
] | Dextropropoxyphene | Thalidomide | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
675,
25,
770
]
],
[
[
675,
6,
6017
],
[
6017,
45,
770
]
],
[
[
675,
21,
28789
],
[
28789,
60,
770
]
],
[
[
675,
24,
609
],
[
609,
... | [
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Dextropropoxyphene",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)... | Dextropropoxyphene (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Thalidomide (Compound)
Dextropropoxyphene (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Thalidomide (Compound)
Dextropropoxyphene may cause a moderate interaction that could exace... |
DB00893 | DB06782 | 1,656 | 1,575 | [
"DDInter976",
"DDInter563"
] | Iron Dextran | Dimercaprol | Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron Dextran is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible. | Dimercaprol is a traditional chelating agent developed by British biochemists at Oxford University during World War II. It was developed as an experimental antidote against the arsenic-based poison gas Lewisite. It has been used clinically since 1949 in arsenic, cadmium and mercury poisoning. In addition, it has in the... | Major | 2 | [
[
[
1656,
25,
1575
]
],
[
[
1656,
24,
1596
],
[
1596,
25,
1575
]
],
[
[
1656,
24,
428
],
[
428,
64,
1575
]
],
[
[
1656,
24,
1596
],
[
1596... | [
[
[
"Iron Dextran",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dimercaprol"
]
],
[
[
"Iron Dextran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
],
[
"Iron",
... | Iron Dextran may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may lead to a major life threatening interaction when taken with Dimercaprol
Iron Dextran may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous fumarate may l... |
DB00342 | DB00647 | 1,181 | 675 | [
"DDInter1770",
"DDInter528"
] | Terfenadine | Dextropropoxyphene | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Moderate | 1 | [
[
[
1181,
24,
675
]
],
[
[
1181,
24,
888
],
[
888,
64,
675
]
],
[
[
1181,
64,
494
],
[
494,
1,
675
]
],
[
[
1181,
24,
307
],
[
307,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
],... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may lead to a major life threatening interaction when taken with Dextropropoxyphene
Terfenadine may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) re... |
DB06589 | DB11057 | 1,250 | 720 | [
"DDInter1400",
"DDInter1223"
] | Pazopanib | Mineral oil | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
1250,
24,
720
]
],
[
[
1250,
24,
927
],
[
927,
63,
720
]
],
[
[
1250,
63,
1151
],
[
1151,
24,
720
]
],
[
[
1250,
64,
1069
],
[
1069,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[
... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Suniti... |
DB05578 | DB08896 | 330 | 292 | [
"DDInter1566",
"DDInter1576"
] | Ramucirumab | Regorafenib | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Major | 2 | [
[
[
330,
25,
292
]
],
[
[
330,
24,
643
],
[
643,
24,
292
]
],
[
[
330,
63,
901
],
[
901,
24,
292
]
],
[
[
330,
24,
384
],
[
384,
63,... | [
[
[
"Ramucirumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
]
],
[
[
"Ramucirumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
],
[
"Des... | Ramucirumab may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Regorafenib
Ramucirumab may cause a moderate interaction that could exacerbate diseases when taken with Milnacipra... |
DB00060 | DB00108 | 912 | 1,066 | [
"DDInter947",
"DDInter1268"
] | Interferon beta-1a | Natalizumab | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Major | 2 | [
[
[
912,
25,
1066
]
],
[
[
912,
24,
267
],
[
267,
63,
1066
]
],
[
[
912,
24,
1011
],
[
1011,
64,
1066
]
],
[
[
912,
25,
1510
],
[
1510,
... | [
[
[
"Interferon beta-1a",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Natalizumab"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
[
... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Natalizumab
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Fing... |
DB00280 | DB01233 | 494 | 1,311 | [
"DDInter575",
"DDInter1197"
] | Disopyramide | Metoclopramide | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
494,
24,
1311
]
],
[
[
494,
25,
1151
],
[
1151,
40,
1311
]
],
[
[
494,
6,
7992
],
[
7992,
45,
1311
]
],
[
[
494,
21,
28691
],
[
28691,... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sunitinib"
],
[
"Sun... | Disopyramide may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib (Compound) resembles Metoclopramide (Compound)
Disopyramide (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Metoclopramide (Compound)
Disopyramide (Compound) causes Somnolence (Side Effect) and Somnolence (S... |
DB00013 | DB00574 | 1,255 | 121 | [
"DDInter1905",
"DDInter717"
] | Urokinase | Fenfluramine | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Moderate | 1 | [
[
[
1255,
24,
121
]
],
[
[
1255,
25,
366
],
[
366,
24,
121
]
],
[
[
1255,
24,
24
],
[
24,
24,
121
]
],
[
[
1255,
24,
958
],
[
958,
6... | [
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
]
],
[
[
"Urokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eptifibatide"
],
[
"Eptifiba... | Urokinase may lead to a major life threatening interaction when taken with Eptifibatide and Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Tolmetin and Tolmetin may cause ... |
DB00030 | DB00584 | 1,685 | 610 | [
"DDInter934",
"DDInter638"
] | Insulin human | Enalapril | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Moderate | 1 | [
[
[
1685,
24,
610
]
],
[
[
1685,
24,
743
],
[
743,
1,
610
]
],
[
[
1685,
24,
954
],
[
954,
40,
610
]
],
[
[
1685,
24,
170
],
[
170,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril (Compound) resembles Enalapril (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Enalapril (Compound... |
DB08880 | DB15982 | 1,510 | 1,339 | [
"DDInter1771",
"DDInter193"
] | Teriflunomide | Berotralstat | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Major | 2 | [
[
[
1510,
25,
1339
]
],
[
[
1510,
64,
1101
],
[
1101,
23,
1339
]
],
[
[
1510,
25,
283
],
[
283,
23,
1339
]
],
[
[
1510,
64,
1213
],
[
1213... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Berotralstat"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",
... | Teriflunomide may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Teriflunomide may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a minor i... |
DB00026 | DB01229 | 1,184 | 973 | [
"DDInter94",
"DDInter1377"
] | Anakinra | Paclitaxel | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
1184,
24,
973
]
],
[
[
1184,
24,
310
],
[
310,
63,
973
]
],
[
[
1184,
24,
134
],
[
134,
24,
973
]
],
[
[
1184,
25,
980
],
[
980,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorel... |
DB00738 | DB00877 | 485 | 629 | [
"DDInter1420",
"DDInter1678"
] | Pentamidine | Sirolimus | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Major | 2 | [
[
[
485,
25,
629
]
],
[
[
485,
6,
7524
],
[
7524,
45,
629
]
],
[
[
485,
7,
3603
],
[
3603,
46,
629
]
],
[
[
485,
18,
2947
],
[
2947,
... | [
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
]
],
[
[
"Pentamidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
"Siroli... | Pentamidine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Sirolimus (Compound)
Pentamidine (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) is upregulated by Sirolimus (Compound)
Pentamidine (Compound) downregulates DECR1 (Gene) and DECR1 (Gene) is upregulated by Sirolimus (Compound)
Pentamidine (Com... |
DB00911 | DB11652 | 458 | 1,155 | [
"DDInter1811",
"DDInter1891"
] | Tinidazole | Tucatinib | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Moderate | 1 | [
[
[
458,
24,
1155
]
],
[
[
458,
63,
1101
],
[
1101,
23,
1155
]
],
[
[
458,
63,
522
],
[
522,
24,
1155
]
],
[
[
458,
24,
309
],
[
309,
... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tucatinib"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirluk... |
DB00745 | DB01058 | 307 | 978 | [
"DDInter1236",
"DDInter1510"
] | Modafinil | Praziquantel | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infecti... | Moderate | 1 | [
[
[
307,
24,
978
]
],
[
[
307,
6,
7524
],
[
7524,
45,
978
]
],
[
[
307,
21,
28709
],
[
28709,
60,
978
]
],
[
[
307,
62,
752
],
[
752,
... | [
[
[
"Modafinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Praziquantel"
]
],
[
[
"Modafinil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",... | Modafinil (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Praziquantel (Compound)
Modafinil (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Praziquantel (Compound)
Modafinil may cause a minor interaction that can limit clinical effects when taken with Ci... |
DB00252 | DB12130 | 362 | 1,017 | [
"DDInter1460",
"DDInter1094"
] | Phenytoin | Lorlatinib | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Major | 2 | [
[
[
362,
25,
1017
]
],
[
[
362,
23,
608
],
[
608,
23,
1017
]
],
[
[
362,
24,
590
],
[
590,
24,
1017
]
],
[
[
362,
25,
976
],
[
976,
... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
]
],
[
[
"Phenytoin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lidocaine"
],
[
"Lidocaine",
... | Phenytoin may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexami... |
DB01018 | DB09046 | 1,364 | 1,094 | [
"DDInter847",
"DDInter1201"
] | Guanfacine | Metreleptin | Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approva... | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Moderate | 1 | [
[
[
1364,
24,
1094
]
],
[
[
1364,
24,
578
],
[
578,
24,
1094
]
],
[
[
1364,
24,
927
],
[
927,
63,
1094
]
],
[
[
1364,
25,
384
],
[
384,
... | [
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
]
],
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
... | Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin
Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Enco... |
DB00682 | DB09278 | 126 | 852 | [
"DDInter1951",
"DDInter24"
] | Warfarin | Activated charcoal | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Moderate | 1 | [
[
[
126,
24,
852
]
],
[
[
126,
63,
21
],
[
21,
24,
852
]
],
[
[
126,
24,
1411
],
[
1411,
24,
852
]
],
[
[
126,
62,
1647
],
[
1647,
2... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Activated charcoal"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amitriptyline"
],
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Activated charcoal
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide... |
DB00747 | DB01010 | 1,442 | 61 | [
"DDInter1647",
"DDInter622"
] | Scopolamine | Edrophonium | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. | Moderate | 1 | [
[
[
1442,
24,
61
]
],
[
[
1442,
63,
1636
],
[
1636,
1,
61
]
],
[
[
1442,
24,
768
],
[
768,
40,
61
]
],
[
[
1442,
24,
1372
],
[
1372,
... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edrophonium"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine (Compound) resembles Edrophonium (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Tapentadol and Tapentadol (Compound) resembles Edrophonium (... |
DB01229 | DB11988 | 973 | 270 | [
"DDInter1377",
"DDInter1321"
] | Paclitaxel | Ocrelizumab | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
973,
24,
270
]
],
[
[
973,
63,
1461
],
[
1461,
23,
270
]
],
[
[
973,
24,
1060
],
[
1060,
63,
270
]
],
[
[
973,
63,
134
],
[
134,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and E... |
DB00900 | DB06674 | 45 | 908 | [
"DDInter544",
"DDInter837"
] | Didanosine | Golimumab | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
45,
24,
908
]
],
[
[
45,
63,
268
],
[
268,
24,
908
]
],
[
[
45,
24,
458
],
[
458,
24,
908
]
],
[
[
45,
24,
1434
],
[
1434,
63,
... | [
[
[
"Didanosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Didanosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
]... | Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Didanosine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00924 | DB01619 | 1,405 | 830 | [
"DDInter454",
"DDInter1441"
] | Cyclobenzaprine | Phenindamine | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1405,
24,
830
]
],
[
[
1405,
24,
537
],
[
537,
40,
830
]
],
[
[
1405,
40,
114
],
[
114,
1,
830
]
],
[
[
1405,
63,
1219
],
[
1219,
... | [
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
... | Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Cyclobenzaprine (Compound) resembles Nortriptyline (Compound) and Nortriptyline (Compound) resembles Phenindamine (Compound)
Cyclobenzaprine may cause a mo... |
DB00394 | DB13139 | 218 | 1,032 | [
"DDInter168",
"DDInter1063"
] | Beclomethasone dipropionate | Levosalbutamol | Beclomethasone dipropionate is a second-generation synthetic corticosteroid and diester of beclomethasone, which is structurally similar to [dexamethasone]. It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP) which acts on the glucocorticoid receptor to mediates its therapeutic action. Bec... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Minor | 0 | [
[
[
218,
23,
1032
]
],
[
[
218,
1,
1220
],
[
1220,
23,
1032
]
],
[
[
218,
23,
659
],
[
659,
24,
1032
]
],
[
[
218,
1,
1220
],
[
1220,
... | [
[
[
"Beclomethasone dipropionate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Beclomethasone dipropionate",
"{u} (Compound) resembles {v} (Compound)",
"Dexamethasone"
],
[
"Dexa... | Beclomethasone dipropionate (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Beclomethasone dipropionate may cause a minor interaction that can limit clinical effects when taken with Vilanterol and Vilanterol may... |
DB00531 | DB14761 | 450 | 242 | [
"DDInter456",
"DDInter1578"
] | Cyclophosphamide | Remdesivir | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
450,
24,
242
]
],
[
[
450,
25,
1377
],
[
1377,
24,
242
]
],
[
[
450,
24,
129
],
[
129,
24,
242
]
],
[
[
450,
62,
367
],
[
367,
2... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Cyclophosphamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
],
[
... | Cyclophosphamide may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzal... |
DB00377 | DB00734 | 1,494 | 1,664 | [
"DDInter1382",
"DDInter1605"
] | Palonosetron | Risperidone | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Moderate | 1 | [
[
[
1494,
24,
1664
]
],
[
[
1494,
25,
924
],
[
924,
40,
1664
]
],
[
[
1494,
24,
519
],
[
519,
40,
1664
]
],
[
[
1494,
6,
12523
],
[
12523,... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]
],
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloperidone"
],
[
"Ilop... | Palonosetron may lead to a major life threatening interaction when taken with Iloperidone and Iloperidone (Compound) resembles Risperidone (Compound)
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Risperidone (Compound)
Pal... |
DB08880 | DB09073 | 1,510 | 951 | [
"DDInter1771",
"DDInter1379"
] | Teriflunomide | Palbociclib | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
1510,
25,
951
]
],
[
[
1510,
24,
496
],
[
496,
63,
951
]
],
[
[
1510,
25,
1476
],
[
1476,
63,
951
]
],
[
[
1510,
64,
259
],
[
259,
... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
],
[
... | Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Teriflunomide may lead to a major life threatening interaction when taken with Brigatinib ... |
DB11760 | DB11978 | 119 | 124 | [
"DDInter1742",
"DDInter822"
] | Talazoparib | Glasdegib | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
119,
24,
124
]
],
[
[
119,
24,
466
],
[
466,
62,
124
]
],
[
[
119,
63,
79
],
[
79,
24,
124
]
],
[
[
119,
24,
1339
],
[
1339,
63,... | [
[
[
"Talazoparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Talazoparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[... | Talazoparib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Talazoparib may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sora... |
DB00261 | DB00280 | 702 | 494 | [
"DDInter93",
"DDInter575"
] | Anagrelide | Disopyramide | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Major | 2 | [
[
[
702,
25,
494
]
],
[
[
702,
25,
675
],
[
675,
40,
494
]
],
[
[
702,
25,
576
],
[
576,
1,
494
]
],
[
[
702,
21,
28658
],
[
28658,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Disopyramide"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextropropoxyphene"
],
[
"Dextropropoxyph... | Anagrelide may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Disopyramide (Compound)
Anagrelide may lead to a major life threatening interaction when taken with Methadone and Methadone (Compound) resembles Disopyramide (Compound)
Anagrelide (... |
DB00193 | DB00682 | 534 | 126 | [
"DDInter1841",
"DDInter1951"
] | Tramadol | Warfarin | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
534,
24,
126
]
],
[
[
534,
24,
1376
],
[
1376,
40,
126
]
],
[
[
534,
6,
8374
],
[
8374,
45,
126
]
],
[
[
534,
25,
1053
],
[
1053,
... | [
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[
... | Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Warfarin (Compound)
Tramadol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Warfarin (Compound)
Tramadol may lead to a major life threatening interaction when t... |
DB00014 | DB08864 | 521 | 786 | [
"DDInter839",
"DDInter1595"
] | Goserelin | Rilpivirine | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Moderate | 1 | [
[
[
521,
24,
786
]
],
[
[
521,
21,
28734
],
[
28734,
60,
786
]
],
[
[
521,
23,
112
],
[
112,
23,
786
]
],
[
[
521,
24,
594
],
[
594,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
]
],
[
[
"Goserelin",
"{u} (Compound) causes {v} (Side Effect)",
"Immune system disorder"
],
[
"Immune system disorder",
"... | Goserelin (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Rilpivirine (Compound)
Goserelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effe... |
DB00443 | DB09098 | 251 | 98 | [
"DDInter195",
"DDInter1700"
] | Betamethasone | Somatrem | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
251,
24,
98
]
],
[
[
251,
24,
336
],
[
336,
24,
98
]
],
[
[
251,
24,
159
],
[
159,
63,
98
]
],
[
[
251,
1,
1573
],
[
1573,
24,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and... |
DB00836 | DB01100 | 543 | 1,568 | [
"DDInter1088",
"DDInter1470"
] | Loperamide | Pimozide | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
543,
24,
1568
]
],
[
[
543,
1,
1413
],
[
1413,
40,
1568
]
],
[
[
543,
63,
78
],
[
78,
40,
1568
]
],
[
[
543,
63,
1557
],
[
1557,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Loperamide",
"{u} (Compound) resembles {v} (Compound)",
"Fexofenadine"
],
[
"Fexofenadine",
"{u} (Compound) resemb... | Loperamide (Compound) resembles Fexofenadine (Compound) and Fexofenadine (Compound) resembles Pimozide (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Loperamide may cause a moderate interaction that... |
DB00054 | DB15233 | 1,432 | 1,650 | [
"DDInter6",
"DDInter142"
] | Abciximab | Avapritinib | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
1432,
25,
1650
]
],
[
[
1432,
24,
557
],
[
557,
24,
1650
]
],
[
[
1432,
24,
1512
],
[
1512,
25,
1650
]
],
[
[
1432,
25,
4
],
[
4,
... | [
[
[
"Abciximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deoxycholic acid"
],
[
"Deoxy... | Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid and Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac... |
DB00582 | DB09098 | 1,622 | 98 | [
"DDInter1946",
"DDInter1700"
] | Voriconazole | Somatrem | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1622,
24,
98
]
],
[
[
1622,
63,
608
],
[
608,
23,
98
]
],
[
[
1622,
24,
284
],
[
284,
24,
98
]
],
[
[
1622,
25,
159
],
[
159,
63... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Somatrem
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Finasteride and Finaste... |
DB01319 | DB01611 | 34 | 1,487 | [
"DDInter777",
"DDInter893"
] | Fosamprenavir | Hydroxychloroquine | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
34,
24,
1487
]
],
[
[
34,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
34,
63,
723
],
[
723,
24,
1487
]
],
[
[
34,
25,
1468
],
[
1468,
... | [
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Fosamprenavir",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Eff... | Fosamprenavir (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00011 | DB09074 | 1,451 | 1,362 | [
"DDInter944",
"DDInter1327"
] | Interferon alfa-n1 | Olaparib | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
1451,
24,
1362
]
],
[
[
1451,
24,
896
],
[
896,
24,
1362
]
],
[
[
1451,
25,
139
],
[
139,
24,
1362
]
],
[
[
1451,
23,
450
],
[
450,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Interferon alfa-n1 may lead to a major life threatening interaction when taken with Zidovudine and Zidovudin... |
DB01410 | DB11932 | 423 | 327 | [
"DDInter375",
"DDInter3"
] | Ciclesonide | Abametapir (topical) | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
423,
24,
327
]
],
[
[
423,
62,
455
],
[
455,
24,
327
]
],
[
[
423,
24,
384
],
[
384,
24,
327
]
],
[
[
423,
23,
659
],
[
659,
24,... | [
[
[
"Ciclesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Ciclesonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Salmeterol"
],
[
... | Ciclesonide may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Ciclesonide may cause a minor interaction that can limit clinical effects when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Ciclesonid... |
DB00981 | DB01400 | 1,528 | 1,372 | [
"DDInter1462",
"DDInter1279"
] | Physostigmine | Neostigmine | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. | Moderate | 1 | [
[
[
1528,
24,
1372
]
],
[
[
1528,
63,
751
],
[
751,
40,
1372
]
],
[
[
1528,
24,
61
],
[
61,
24,
1372
]
],
[
[
1528,
6,
10558
],
[
10558,
... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neostigmine"
]
],
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pyridostigmine"
... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Pyridostigmine and Pyridostigmine (Compound) resembles Neostigmine (Compound)
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Edrophonium and Edrophonium may cause a moderate inter... |
DB01227 | DB09272 | 1,301 | 412 | [
"DDInter1043",
"DDInter632"
] | Levacetylmethadol | Eluxadoline | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
1301,
24,
412
]
],
[
[
1301,
75,
1594
],
[
1594,
24,
412
]
],
[
[
1301,
74,
543
],
[
543,
24,
412
]
],
[
[
1301,
25,
849
],
[
849,
... | [
[
[
"Levacetylmethadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Levacetylmethadol",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken w... | Levacetylmethadol (Compound) resembles Doxylamine (Compound) and Levacetylmethadol may lead to a major life threatening interaction when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Levacetylmethadol (Compound) resembles Loperamide (Com... |
DB00880 | DB01101 | 359 | 60 | [
"DDInter360",
"DDInter285"
] | Chlorothiazide | Capecitabine | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Moderate | 1 | [
[
[
359,
24,
60
]
],
[
[
359,
21,
28921
],
[
28921,
60,
60
]
],
[
[
359,
24,
286
],
[
286,
62,
60
]
],
[
[
359,
40,
1577
],
[
1577,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capecitabine"
]
],
[
[
"Chlorothiazide",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effec... | Chlorothiazide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Capecitabine (Compound)
Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effec... |
DB00264 | DB01268 | 88 | 1,151 | [
"DDInter1200",
"DDInter1731"
] | Metoprolol | Sunitinib | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
88,
24,
1151
]
],
[
[
88,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
88,
21,
29269
],
[
29269,
60,
1151
]
],
[
[
88,
24,
1148
],
[
1148,
... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Metoprolol",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Metoprolol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Metoprolol (Compound) causes Menopausal symptoms (Side Effect) and Menopausal symptoms (Side Effect) is caused by Sunitinib (Compound)
Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Iso... |
DB00700 | DB09054 | 312 | 384 | [
"DDInter656",
"DDInter905"
] | Eplerenone | Idelalisib | Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone c... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
312,
25,
384
]
],
[
[
312,
24,
891
],
[
891,
24,
384
]
],
[
[
312,
63,
1512
],
[
1512,
24,
384
]
],
[
[
312,
64,
600
],
[
600,
2... | [
[
[
"Eplerenone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Eplerenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
],
[
"Predniso... | Eplerenone may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Eplerenone may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Di... |
DB01128 | DB08903 | 918 | 996 | [
"DDInter204",
"DDInter170"
] | Bicalutamide | Bedaquiline | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Major | 2 | [
[
[
918,
25,
996
]
],
[
[
918,
6,
8374
],
[
8374,
45,
996
]
],
[
[
918,
21,
29282
],
[
29282,
60,
996
]
],
[
[
918,
62,
112
],
[
112,
... | [
[
[
"Bicalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
]
],
[
[
"Bicalutamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Be... | Bicalutamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound)
Bicalutamide (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Bedaquiline (Compound)
Bicalutamide may cause a minor interaction that can limit clinical effects when taken with Metronidazo... |
DB00381 | DB09098 | 376 | 98 | [
"DDInter79",
"DDInter1700"
] | Amlodipine | Somatrem | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
376,
24,
98
]
],
[
[
376,
1,
336
],
[
336,
24,
98
]
],
[
[
376,
24,
159
],
[
159,
63,
98
]
],
[
[
376,
24,
1573
],
[
1573,
24,
... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Amlodipine",
"{u} (Compound) resembles {v} (Compound)",
"Nifedipine"
],
[
"Nifedipine",
"{u} may cause a moderate ... | Amlodipine (Compound) resembles Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Amlodipine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that c... |
DB04946 | DB12130 | 924 | 1,017 | [
"DDInter907",
"DDInter1094"
] | Iloperidone | Lorlatinib | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
924,
24,
1017
]
],
[
[
924,
63,
590
],
[
590,
24,
1017
]
],
[
[
924,
25,
1491
],
[
1491,
24,
1017
]
],
[
[
924,
64,
888
],
[
888,
... | [
[
[
"Iloperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Iloperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
],
... | Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Iloperidone may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin ... |
DB06779 | DB12364 | 365 | 1,421 | [
"DDInter470",
"DDInter200"
] | Dalteparin | Betrixaban | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
365,
25,
1421
]
],
[
[
365,
23,
297
],
[
297,
23,
1421
]
],
[
[
365,
23,
1631
],
[
1631,
62,
1421
]
],
[
[
365,
24,
992
],
[
992,
... | [
[
[
"Dalteparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Dalteparin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u... | Dalteparin may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Betrixaban
Dalteparin may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a min... |
DB01177 | DB08871 | 77 | 36 | [
"DDInter904",
"DDInter666"
] | Idarubicin | Eribulin | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
77,
24,
36
]
],
[
[
77,
5,
11579
],
[
11579,
44,
36
]
],
[
[
77,
63,
122
],
[
122,
23,
36
]
],
[
[
77,
62,
1247
],
[
1247,
23,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Idarubicin",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is treate... | Idarubicin (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Eribulin (Compound)
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Verapamil may cause a minor interaction that can limit clinical effects when taken with Eribulin
Ida... |
DB00163 | DB09030 | 1,461 | 840 | [
"DDInter1943",
"DDInter1945"
] | Vitamin E | Vorapaxar | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Moderate | 1 | [
[
[
1461,
24,
840
]
],
[
[
1461,
24,
885
],
[
885,
24,
840
]
],
[
[
1461,
24,
500
],
[
500,
25,
840
]
],
[
[
1461,
63,
1578
],
[
1578,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vorapaxar"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin and Enoxa... |
DB00526 | DB15091 | 1,555 | 676 | [
"DDInter1355",
"DDInter1901"
] | Oxaliplatin | Upadacitinib | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1555,
25,
676
]
],
[
[
1555,
63,
1461
],
[
1461,
23,
676
]
],
[
[
1555,
24,
1430
],
[
1430,
24,
676
]
],
[
[
1555,
25,
1593
],
[
1593,... | [
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipu... |
DB00374 | DB01021 | 1,061 | 674 | [
"DDInter1852",
"DDInter1861"
] | Treprostinil | Trichlormethiazide | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Moderate | 1 | [
[
[
1061,
24,
674
]
],
[
[
1061,
24,
1014
],
[
1014,
40,
674
]
],
[
[
1061,
24,
178
],
[
178,
1,
674
]
],
[
[
1061,
18,
8358
],
[
8358,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazide"
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles Tr... |
DB00188 | DB00241 | 168 | 288 | [
"DDInter222",
"DDInter257"
] | Bortezomib | Butalbital | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Minor | 0 | [
[
[
168,
23,
288
]
],
[
[
168,
23,
1023
],
[
1023,
1,
288
]
],
[
[
168,
23,
536
],
[
536,
40,
288
]
],
[
[
168,
23,
1101
],
[
1101,
... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Butalbital"
]
],
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pentobarbital"
],
[
... | Bortezomib may cause a minor interaction that can limit clinical effects when taken with Pentobarbital and Pentobarbital (Compound) resembles Butalbital (Compound)
Bortezomib may cause a minor interaction that can limit clinical effects when taken with Secobarbital and Secobarbital (Compound) resembles Butalbital (Comp... |
DB00277 | DB13139 | 1,031 | 1,032 | [
"DDInter1791",
"DDInter1063"
] | Theophylline | Levosalbutamol | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
1031,
24,
1032
]
],
[
[
1031,
24,
1573
],
[
1573,
23,
1032
]
],
[
[
1031,
24,
985
],
[
985,
24,
1032
]
],
[
[
1031,
23,
22
],
[
22,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib and... |
DB09381 | DB14568 | 192 | 982 | [
"DDInter678",
"DDInter1000"
] | Esterified estrogens | Ivosidenib | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
192,
24,
982
]
],
[
[
192,
63,
1101
],
[
1101,
23,
982
]
],
[
[
192,
64,
770
],
[
770,
24,
982
]
],
[
[
192,
24,
1476
],
[
1476,
... | [
[
[
"Esterified estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Esterified estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarot... | Esterified estrogens may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Esterified estrogens may lead to a major life threatening interaction when taken with Thalidomide and Th... |
DB11988 | DB12332 | 270 | 1,619 | [
"DDInter1321",
"DDInter1626"
] | Ocrelizumab | Rucaparib | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
270,
24,
1619
]
],
[
[
270,
63,
259
],
[
259,
24,
1619
]
],
[
[
270,
24,
151
],
[
151,
63,
1619
]
],
[
[
270,
24,
1476
],
[
1476,
... | [
[
[
"Ocrelizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Ocrelizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
[
... | Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/... |
DB00281 | DB00607 | 608 | 1,249 | [
"DDInter1066",
"DDInter1256"
] | Lidocaine | Nafcillin | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Minor | 0 | [
[
[
608,
23,
1249
]
],
[
[
608,
6,
7950
],
[
7950,
45,
1249
]
],
[
[
608,
21,
28792
],
[
28792,
60,
1249
]
],
[
[
608,
23,
1101
],
[
1101,... | [
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nafcillin"
]
],
[
[
"Lidocaine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Lidocaine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nafcillin (Compound)
Lidocaine (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Nafcillin (Compound)
Lidocaine may cause a minor interaction that can limit clinical effects when taken... |
DB00444 | DB06688 | 63 | 1,430 | [
"DDInter1765",
"DDInter1677"
] | Teniposide | Sipuleucel-T | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
63,
24,
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]
],
[
[
63,
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[
869,
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[
[
63,
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],
[
676,
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]
],
[
[
63,
24,
310
],
[
310,
63,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
],
[
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Teniposide may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may ca... |
DB00405 | DB00765 | 128 | 1,266 | [
"DDInter517",
"DDInter1205"
] | Dexbrompheniramine | Metyrosine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed) | Moderate | 1 | [
[
[
128,
24,
1266
]
],
[
[
128,
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662
],
[
662,
24,
1266
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],
[
[
128,
24,
401
],
[
401,
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1266
]
],
[
[
128,
63,
999
],
[
999,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metyrosine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxami... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Metyrosine
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00454 | DB06209 | 1,349 | 256 | [
"DDInter1150",
"DDInter1508"
] | Meperidine | Prasugrel | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Moderate | 1 | [
[
[
1349,
24,
256
]
],
[
[
1349,
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10215
],
[
10215,
45,
256
]
],
[
[
1349,
21,
28681
],
[
28681,
60,
256
]
],
[
[
1349,
24,
752
],
[
752... | [
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prasugrel"
]
],
[
[
"Meperidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)"... | Meperidine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Prasugrel (Compound)
Meperidine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Prasugrel (Compound)
Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Cimet... |
DB00731 | DB00819 | 1,144 | 471 | [
"DDInter1269",
"DDInter15"
] | Nateglinide | Acetazolamide | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its ... | Moderate | 1 | [
[
[
1144,
24,
471
]
],
[
[
1144,
63,
997
],
[
997,
40,
471
]
],
[
[
1144,
6,
8374
],
[
8374,
45,
471
]
],
[
[
1144,
21,
28972
],
[
28972,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetazolamide"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methazolamide"
],
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Methazolamide and Methazolamide (Compound) resembles Acetazolamide (Compound)
Nateglinide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Acetazolamide (Compound)
Nateglinide (Compound) causes Urine output increased... |
DB08881 | DB12035 | 868 | 943 | [
"DDInter1925",
"DDInter1641"
] | Vemurafenib | Sarecycline | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
868,
24,
943
]
],
[
[
868,
23,
1135
],
[
1135,
23,
943
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],
[
[
868,
64,
1181
],
[
1181,
24,
943
]
],
[
[
868,
25,
1456
],
[
1456,
... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Vemurafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Vemurafenib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Sarecycline
Vemurafenib may lead to a major life threatening interaction when taken with Terfenadine and Terfenadine may cause a... |
DB00400 | DB14881 | 353 | 180 | [
"DDInter843",
"DDInter1329"
] | Griseofulvin | Oliceridine | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
353,
24,
180
]
],
[
[
353,
24,
124
],
[
124,
24,
180
]
],
[
[
353,
63,
1010
],
[
1010,
24,
180
]
],
[
[
353,
62,
1101
],
[
1101,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
],
... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mef... |
DB01238 | DB11986 | 673 | 484 | [
"DDInter118",
"DDInter648"
] | Aripiprazole | Entrectinib | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
673,
24,
484
]
],
[
[
673,
62,
112
],
[
112,
23,
484
]
],
[
[
673,
63,
222
],
[
222,
23,
484
]
],
[
[
673,
24,
774
],
[
774,
24,... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Aripiprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Aripiprazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine an... |
DB00372 | DB00421 | 999 | 443 | [
"DDInter1793",
"DDInter1707"
] | Thiethylperazine | Spironolactone | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Moderate | 1 | [
[
[
999,
24,
443
]
],
[
[
999,
24,
312
],
[
312,
40,
443
]
],
[
[
999,
24,
1374
],
[
1374,
63,
443
]
],
[
[
999,
25,
593
],
[
593,
6... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Spironolactone"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eplerenone"... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone (Compound) resembles Spironolactone (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a moderate inte... |
DB00621 | DB06404 | 1,026 | 1,514 | [
"DDInter1357",
"DDInter869"
] | Oxandrolone | Human C1-esterase inhibitor | A synthetic hormone with anabolic and androgenic properties. | C1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways.[L16586, L16606] This drug is indicated for prophylaxis and... | Moderate | 1 | [
[
[
1026,
24,
1514
]
],
[
[
1026,
40,
984
],
[
984,
24,
1514
]
],
[
[
1026,
40,
1546
],
[
1546,
63,
1514
]
],
[
[
1026,
25,
350
],
[
350,
... | [
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human C1-esterase inhibitor"
]
],
[
[
"Oxandrolone",
"{u} (Compound) resembles {v} (Compound)",
"Danazol"
],
[
"Danazol",
"{u} may ca... | Oxandrolone (Compound) resembles Danazol (Compound) and Danazol may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Oxandrolone (Compound) resembles Methyltestosterone (Compound) and Methyltestosterone may cause a moderate interaction that could exacerbate disease... |
DB00261 | DB00749 | 702 | 59 | [
"DDInter93",
"DDInter699"
] | Anagrelide | Etodolac | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Moderate | 1 | [
[
[
702,
24,
59
]
],
[
[
702,
21,
29187
],
[
29187,
60,
59
]
],
[
[
702,
24,
1559
],
[
1559,
62,
59
]
],
[
[
702,
24,
752
],
[
752,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etodolac"
]
],
[
[
"Anagrelide",
"{u} (Compound) causes {v} (Side Effect)",
"Rhinitis"
],
[
"Rhinitis",
"{u} (Side Effect) is caused b... | Anagrelide (Compound) causes Rhinitis (Side Effect) and Rhinitis (Side Effect) is caused by Etodolac (Compound)
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Famotidine and Famotidine may cause a minor interaction that can limit clinical effects when taken with Etodolac
Anag... |
DB01166 | DB06176 | 477 | 1,342 | [
"DDInter379",
"DDInter1616"
] | Cilostazol | Romidepsin | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
477,
24,
1342
]
],
[
[
477,
62,
1247
],
[
1247,
23,
1342
]
],
[
[
477,
63,
336
],
[
336,
24,
1342
]
],
[
[
477,
24,
1616
],
[
1616,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Cilostazol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Cilostazol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine an... |
DB01069 | DB06702 | 401 | 573 | [
"DDInter1533",
"DDInter731"
] | Promethazine | Fesoterodine | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
401,
24,
573
]
],
[
[
401,
63,
211
],
[
211,
1,
573
]
],
[
[
401,
64,
494
],
[
494,
1,
573
]
],
[
[
401,
6,
12523
],
[
12523,
45... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Promethazine may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) resembles Fesoterodine (Compound)
P... |
DB00834 | DB11113 | 932 | 657 | [
"DDInter1215",
"DDInter307"
] | Mifepristone | Castor oil | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
932,
24,
657
]
],
[
[
932,
25,
927
],
[
927,
63,
657
]
],
[
[
932,
25,
1491
],
[
1491,
24,
657
]
],
[
[
932,
64,
1181
],
[
1181,
... | [
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encor... | Mifepristone may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Mifepristone may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cause a moder... |
DB06077 | DB12267 | 879 | 1,476 | [
"DDInter1102",
"DDInter233"
] | Lumateperone | Brigatinib | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
879,
25,
1476
]
],
[
[
879,
63,
629
],
[
629,
24,
1476
]
],
[
[
879,
24,
951
],
[
951,
24,
1476
]
],
[
[
879,
24,
1385
],
[
1385,
... | [
[
[
"Lumateperone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
],
[
"Sirolim... | Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Pal... |
DB00075 | DB01381 | 541 | 958 | [
"DDInter1250",
"DDInter819"
] | Muromonab | Ginkgo biloba | Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type... | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
541,
24,
958
]
],
[
[
541,
25,
593
],
[
593,
24,
958
]
],
[
[
541,
24,
1503
],
[
1503,
24,
958
]
],
[
[
541,
25,
593
],
[
593,
6... | [
[
[
"Muromonab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Muromonab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
],
[
"Bupropion"... | Muromonab may lead to a major life threatening interaction when taken with Bupropion and Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Muromonab may cause a moderate interaction that could exacerbate diseases when taken with Lindane and Lindane may cause a moder... |
DB06372 | DB11760 | 259 | 119 | [
"DDInter1594",
"DDInter1742"
] | Rilonacept | Talazoparib | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
259,
24,
119
]
],
[
[
259,
63,
66
],
[
66,
24,
119
]
],
[
[
259,
24,
1129
],
[
1129,
63,
119
]
],
[
[
259,
24,
713
],
[
713,
24,... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"
],
[
... | Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e s... |
DB00263 | DB00682 | 1,029 | 126 | [
"DDInter1727",
"DDInter1951"
] | Sulfisoxazole | Warfarin | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Major | 2 | [
[
[
1029,
25,
126
]
],
[
[
1029,
6,
6017
],
[
6017,
45,
126
]
],
[
[
1029,
24,
663
],
[
663,
23,
126
]
],
[
[
1029,
24,
1411
],
[
1411,
... | [
[
[
"Sulfisoxazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
]
],
[
[
"Sulfisoxazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"War... | Sulfisoxazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Warfarin (Compound)
Sulfisoxazole may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Warfarin
Sulfisoxazole ... |
DB01132 | DB08886 | 1,130 | 637 | [
"DDInter1472",
"DDInter126"
] | Pioglitazone | Asparaginase Erwinia chrysanthemi | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
1130,
24,
637
]
],
[
[
1130,
24,
392
],
[
392,
24,
637
]
],
[
[
1130,
63,
167
],
[
167,
24,
637
]
],
[
[
1130,
24,
159
],
[
159,
... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00470 | DB00575 | 530 | 1,020 | [
"DDInter601",
"DDInter412"
] | Dronabinol | Clonidine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974. | Moderate | 1 | [
[
[
530,
24,
1020
]
],
[
[
530,
24,
1617
],
[
1617,
40,
1020
]
],
[
[
530,
6,
8374
],
[
8374,
45,
1020
]
],
[
[
530,
21,
28810
],
[
28810,... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Clonidine (Compound)
Dronabinol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clonidine (Compound)
Dronabinol (Compound) causes Gastrointestinal pain (Side Effec... |
DB00951 | DB06292 | 1,072 | 549 | [
"DDInter986",
"DDInter474"
] | Isoniazid | Dapagliflozin | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1072,
24,
549
]
],
[
[
1072,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1072,
6,
8717
],
[
8717,
45,
549
]
],
[
[
1072,
21,
28882
],
[
28882... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Isoniazid (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Dapagliflozin (Compound)
Isoniazid (Compound) causes Body temperature increased (... |
DB06414 | DB06697 | 655 | 436 | [
"DDInter703",
"DDInter121"
] | Etravirine | Artemether | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Major | 2 | [
[
[
655,
25,
436
]
],
[
[
655,
6,
6017
],
[
6017,
45,
436
]
],
[
[
655,
63,
353
],
[
353,
24,
436
]
],
[
[
655,
25,
283
],
[
283,
63... | [
[
[
"Etravirine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Artemether"
]
],
[
[
"Etravirine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Artemet... | Etravirine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Artemether (Compound)
Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Artemether
Etravirine may... |
DB00461 | DB00758 | 598 | 1,347 | [
"DDInter1254",
"DDInter413"
] | Nabumetone | Clopidogrel | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Moderate | 1 | [
[
[
598,
24,
1347
]
],
[
[
598,
63,
1018
],
[
1018,
25,
1347
]
],
[
[
598,
6,
7950
],
[
7950,
45,
1347
]
],
[
[
598,
18,
16229
],
[
16229,... | [
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
]
],
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticlopidine"
],
[
... | Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticlopidine may lead to a major life threatening interaction when taken with Clopidogrel
Nabumetone (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Clopidogrel (Compound)
Nabumetone (Compound) downreg... |
DB09054 | DB09074 | 384 | 1,362 | [
"DDInter905",
"DDInter1327"
] | Idelalisib | Olaparib | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
384,
25,
1362
]
],
[
[
384,
24,
725
],
[
725,
63,
1362
]
],
[
[
384,
63,
896
],
[
896,
24,
1362
]
],
[
[
384,
64,
588
],
[
588,
... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Satralizumab"
],
[
"Satralizum... | Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab and Satralizumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etopo... |
DB00692 | DB00697 | 274 | 876 | [
"DDInter1448",
"DDInter1821"
] | Phentolamine | Tizanidine | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an extremely painful and debi... | Major | 2 | [
[
[
274,
25,
876
]
],
[
[
274,
63,
1020
],
[
1020,
1,
876
]
],
[
[
274,
6,
10811
],
[
10811,
45,
876
]
],
[
[
274,
21,
28900
],
[
28900,
... | [
[
[
"Phentolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tizanidine"
]
],
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
[
"Clonidi... | Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine (Compound) resembles Tizanidine (Compound)
Phentolamine (Compound) binds NISCH (Gene) and NISCH (Gene) is bound by Tizanidine (Compound)
Phentolamine (Compound) causes Abdominal pain (Side Effect) and Ab... |
DB00704 | DB08896 | 267 | 292 | [
"DDInter1263",
"DDInter1576"
] | Naltrexone | Regorafenib | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
267,
24,
292
]
],
[
[
267,
63,
79
],
[
79,
1,
292
]
],
[
[
267,
6,
15705
],
[
15705,
45,
292
]
],
[
[
267,
21,
28890
],
[
28890,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Naltrexone (Compound) binds UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Regorafenib (Compound)
Naltrexone (Compound) causes Myocardial infarction (Side Effect) a... |
DB01176 | DB01267 | 537 | 519 | [
"DDInter453",
"DDInter1381"
] | Cyclizine | Paliperidone | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
537,
24,
519
]
],
[
[
537,
63,
1664
],
[
1664,
1,
519
]
],
[
[
537,
24,
924
],
[
924,
1,
519
]
],
[
[
537,
6,
10104
],
[
10104,
... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
... | Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone and Iloperidone (Compound) resembles Paliperidone (Comp... |
DB00231 | DB00372 | 1,174 | 999 | [
"DDInter1761",
"DDInter1793"
] | Temazepam | Thiethylperazine | Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chem... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Moderate | 1 | [
[
[
1174,
24,
999
]
],
[
[
1174,
23,
460
],
[
460,
62,
999
]
],
[
[
1174,
24,
1614
],
[
1614,
63,
999
]
],
[
[
1174,
1,
523
],
[
523,
... | [
[
[
"Temazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Temazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
... | Temazepam may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate and Magnesium carbonate may cause a minor interaction that can limit clinical effects when taken with Thiethylperazine
Temazepam may cause a moderate interaction that could exacerbate diseases when taken with Nab... |
DB00158 | DB00795 | 356 | 50 | [
"DDInter771",
"DDInter1725"
] | Folic acid | Sulfasalazine | Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic aci... | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Minor | 0 | [
[
[
356,
23,
50
]
],
[
[
356,
24,
161
],
[
161,
1,
50
]
],
[
[
356,
6,
16081
],
[
16081,
45,
50
]
],
[
[
356,
24,
697
],
[
697,
62,
... | [
[
[
"Folic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Folic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfadiazine"
],
[... | Folic acid may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine (Compound) resembles Sulfasalazine (Compound)
Folic acid (Compound) binds SLC46A1 (Gene) and SLC46A1 (Gene) is bound by Sulfasalazine (Compound)
Folic acid may cause a moderate interaction that could... |
DB00241 | DB00471 | 288 | 201 | [
"DDInter257",
"DDInter1242"
] | Butalbital | Montelukast | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Moderate | 1 | [
[
[
288,
24,
201
]
],
[
[
288,
24,
1220
],
[
1220,
63,
201
]
],
[
[
288,
40,
1023
],
[
1023,
24,
201
]
],
[
[
288,
1,
536
],
[
536,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Montelukast"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Montelukast
Butalbital (Compound) resembles Pentobarbital (Compound) and Pentobarbital may cause a moderate interacti... |
DB00812 | DB01105 | 998 | 222 | [
"DDInter1451",
"DDInter1665"
] | Phenylbutazone | Sibutramine | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
998,
24,
222
]
],
[
[
998,
6,
8374
],
[
8374,
45,
222
]
],
[
[
998,
24,
384
],
[
384,
62,
222
]
],
[
[
998,
63,
723
],
[
723,
23... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Phenylbutazone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Co... | Phenylbutazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Sibutramine
Phenylbuta... |
DB00470 | DB01242 | 530 | 1,237 | [
"DDInter601",
"DDInter410"
] | Dronabinol | Clomipramine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
530,
24,
1237
]
],
[
[
530,
24,
684
],
[
684,
1,
1237
]
],
[
[
530,
63,
902
],
[
902,
40,
1237
]
],
[
[
530,
24,
272
],
[
272,
2... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
],
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Clomipramine (Compou... |
DB01101 | DB10276 | 60 | 1,624 | [
"DDInter285",
"DDInter1623"
] | Capecitabine | Rotavirus vaccine | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
60,
25,
1624
]
],
[
[
60,
63,
1307
],
[
1307,
25,
1624
]
],
[
[
60,
64,
770
],
[
770,
25,
1624
]
],
[
[
60,
25,
375
],
[
375,
25... | [
[
[
"Capecitabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
],
[
"... | Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan may lead to a major life threatening interaction when taken with Rotavirus vaccine
Capecitabine may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may lead to a ... |
DB00242 | DB00787 | 1,064 | 387 | [
"DDInter392",
"DDInter25"
] | Cladribine | Acyclovir | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young a... | Moderate | 1 | [
[
[
1064,
24,
387
]
],
[
[
1064,
40,
1524
],
[
1524,
40,
387
]
],
[
[
1064,
25,
248
],
[
248,
40,
387
]
],
[
[
1064,
24,
1295
],
[
1295,
... | [
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acyclovir"
]
],
[
[
"Cladribine",
"{u} (Compound) resembles {v} (Compound)",
"Entecavir"
],
[
"Entecavir",
"{u} (Compound) resembles {... | Cladribine (Compound) resembles Entecavir (Compound) and Entecavir (Compound) resembles Acyclovir (Compound)
Cladribine may lead to a major life threatening interaction when taken with Valganciclovir and Valganciclovir (Compound) resembles Acyclovir (Compound)
Cladribine may cause a moderate interaction that could exac... |
DB00207 | DB00539 | 1,570 | 11 | [
"DDInter157",
"DDInter1837"
] | Azithromycin | Toremifene | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Major | 2 | [
[
[
1570,
25,
11
]
],
[
[
1570,
6,
4973
],
[
4973,
45,
11
]
],
[
[
1570,
21,
28936
],
[
28936,
60,
11
]
],
[
[
1570,
23,
112
],
[
112,
... | [
[
[
"Azithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Torem... | Azithromycin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Toremifene (Compound)
Azithromycin (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Toremifene (Compound)
Azithromycin may cause a minor interaction that can limit clinical effects when taken with Metronida... |
DB08882 | DB09100 | 1,281 | 320 | [
"DDInter1070",
"DDInter1799"
] | Linagliptin | Thyroid, porcine | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin w... | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
1281,
24,
320
]
],
[
[
1281,
63,
417
],
[
417,
23,
320
]
],
[
[
1281,
63,
1324
],
[
1324,
24,
320
]
],
[
[
1281,
40,
1002
],
[
1002,
... | [
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralfate"
],
... | Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Thyroid, porcine
Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone an... |
DB00065 | DB00593 | 581 | 1,464 | [
"DDInter923",
"DDInter695"
] | Infliximab | Ethosuximide | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. | Moderate | 1 | [
[
[
581,
24,
1464
]
],
[
[
581,
64,
1184
],
[
1184,
24,
1464
]
],
[
[
581,
25,
1303
],
[
1303,
63,
1464
]
],
[
[
581,
24,
1487
],
[
1487,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethosuximide"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anakinra"
],
[
"Anakinra",... | Infliximab may lead to a major life threatening interaction when taken with Anakinra and Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Ethosuximide
Infliximab may lead to a major life threatening interaction when taken with Guselkumab and Guselkumab may cause a moderate intera... |
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