drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00312 | DB09291 | 1,023 | 741 | [
"DDInter1423",
"DDInter1615"
] | Pentobarbital | Rolapitant | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
1023,
24,
741
]
],
[
[
1023,
24,
1135
],
[
1135,
23,
741
]
],
[
[
1023,
24,
506
],
[
506,
24,
741
]
],
[
[
1023,
24,
159
],
[
159,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Rolapitant
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan an... |
DB00334 | DB00637 | 867 | 1,557 | [
"DDInter1326",
"DDInter128"
] | Olanzapine | Astemizole | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Moderate | 1 | [
[
[
867,
24,
1557
]
],
[
[
867,
6,
8374
],
[
8374,
45,
1557
]
],
[
[
867,
23,
112
],
[
112,
62,
1557
]
],
[
[
867,
24,
770
],
[
770,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Astemizole"
]
],
[
[
"Olanzapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Olanzapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Astemizole (Compound)
Olanzapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Astemizole
Olanzapine may c... |
DB00288 | DB00491 | 1,103 | 127 | [
"DDInter63",
"DDInter1217"
] | Amcinonide | Miglitol | Amcinonide is a corticosteroid. | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Minor | 0 | [
[
[
1103,
23,
127
]
],
[
[
1103,
21,
28787
],
[
28787,
60,
127
]
],
[
[
1103,
1,
1573
],
[
1573,
63,
127
]
],
[
[
1103,
62,
245
],
[
245,
... | [
[
[
"Amcinonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Miglitol"
]
],
[
[
"Amcinonide",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is caused... | Amcinonide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Miglitol (Compound)
Amcinonide (Compound) resembles Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Miglitol
Amcinonide may cause a minor interaction that ... |
DB00889 | DB01015 | 1,133 | 1,247 | [
"DDInter840",
"DDInter1724"
] | Granisetron | Sulfamethoxazole | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Minor | 0 | [
[
[
1133,
23,
1247
]
],
[
[
1133,
6,
8374
],
[
8374,
45,
1247
]
],
[
[
1133,
18,
10375
],
[
10375,
57,
1247
]
],
[
[
1133,
21,
28709
],
[
... | [
[
[
"Granisetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Granisetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sulfamethoxazole (Compound)
Granisetron (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Sulfamethoxazole (Compound)
Granisetron (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is... |
DB00004 | DB00827 | 669 | 646 | [
"DDInter499",
"DDInter383"
] | Denileukin diftitox | Cinoxacin | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Minor | 0 | [
[
[
669,
23,
646
]
],
[
[
669,
23,
1176
],
[
1176,
21,
28845
],
[
28845,
60,
646
]
],
[
[
669,
23,
1467
],
[
1467,
23,
1686
],
[
1686,
6... | [
[
[
"Denileukin diftitox",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cinoxacin"
]
],
[
[
"Denileukin diftitox",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Moxifloxacin"
... | Denileukin diftitox may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Cinoxacin (Compound)
Denileukin diftitox may cause a minor interaction that can limit clinical effects when taken w... |
DB01037 | DB01246 | 1,161 | 820 | [
"DDInter1653",
"DDInter45"
] | Selegiline | Alimemazine | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1161,
24,
820
]
],
[
[
1161,
63,
104
],
[
104,
40,
820
]
],
[
[
1161,
24,
401
],
[
401,
24,
820
]
],
[
[
1161,
40,
939
],
[
939,
... | [
[
[
"Selegiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Selegiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[... | Selegiline may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Selegiline may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction t... |
DB11057 | DB11986 | 720 | 484 | [
"DDInter1223",
"DDInter648"
] | Mineral oil | Entrectinib | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
720,
24,
484
]
],
[
[
720,
63,
1539
],
[
1539,
24,
484
]
],
[
[
720,
24,
180
],
[
180,
63,
484
]
],
[
[
720,
24,
927
],
[
927,
2... | [
[
[
"Mineral oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Mineral oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
],
[
... | Mineral oil may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin and Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Mineral oil may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine and Olic... |
DB00196 | DB01136 | 600 | 772 | [
"DDInter743",
"DDInter305"
] | Fluconazole | Carvedilol | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
600,
24,
772
]
],
[
[
600,
24,
371
],
[
371,
1,
772
]
],
[
[
600,
6,
4973
],
[
4973,
45,
772
]
],
[
[
600,
21,
29224
],
[
29224,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
],
[... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Propafenone and Propafenone (Compound) resembles Carvedilol (Compound)
Fluconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Carvedilol (Compound)
Fluconazole (Compound) causes Rash erythematous (Side Effect) an... |
DB11837 | DB12887 | 1,297 | 1,598 | [
"DDInter1351",
"DDInter1750"
] | Osilodrostat | Tazemetostat | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
1297,
24,
1598
]
],
[
[
1297,
63,
608
],
[
608,
23,
1598
]
],
[
[
1297,
63,
594
],
[
594,
24,
1598
]
],
[
[
1297,
64,
985
],
[
985,
... | [
[
[
"Osilodrostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Osilodrostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
... | Osilodrostat may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Tazemetostat
Osilodrostat may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosut... |
DB00501 | DB12010 | 752 | 214 | [
"DDInter380",
"DDInter785"
] | Cimetidine | Fostamatinib | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
752,
24,
214
]
],
[
[
752,
63,
1428
],
[
1428,
24,
214
]
],
[
[
752,
24,
723
],
[
723,
24,
214
]
],
[
[
752,
24,
861
],
[
861,
6... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Apre... |
DB08881 | DB11915 | 868 | 1,293 | [
"DDInter1925",
"DDInter1909"
] | Vemurafenib | Valbenazine | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Major | 2 | [
[
[
868,
25,
1293
]
],
[
[
868,
62,
112
],
[
112,
23,
1293
]
],
[
[
868,
24,
710
],
[
710,
63,
1293
]
],
[
[
868,
64,
521
],
[
521,
... | [
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Valbenazine"
]
],
[
[
"Vemurafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Vemurafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib and ... |
DB00302 | DB00367 | 335 | 566 | [
"DDInter1844",
"DDInter1061"
] | Tranexamic acid | Levonorgestrel | Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986. | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Major | 2 | [
[
[
335,
25,
566
]
],
[
[
335,
64,
1336
],
[
1336,
40,
566
]
],
[
[
335,
25,
35
],
[
35,
40,
566
]
],
[
[
335,
25,
1197
],
[
1197,
1... | [
[
[
"Tranexamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levonorgestrel"
]
],
[
[
"Tranexamic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etonogestrel"
],
[
"Etonogest... | Tranexamic acid may lead to a major life threatening interaction when taken with Etonogestrel and Etonogestrel (Compound) resembles Levonorgestrel (Compound)
Tranexamic acid may lead to a major life threatening interaction when taken with Quinestrol and Quinestrol (Compound) resembles Levonorgestrel (Compound)
Tranexam... |
DB00776 | DB01229 | 1,335 | 973 | [
"DDInter1360",
"DDInter1377"
] | Oxcarbazepine | Paclitaxel | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
1335,
24,
973
]
],
[
[
1335,
24,
310
],
[
310,
63,
973
]
],
[
[
1335,
6,
7524
],
[
7524,
45,
973
]
],
[
[
1335,
21,
28779
],
[
28779,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
... | Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Oxcarbazepine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Paclitaxel (Compound)
Oxcarbazep... |
DB01149 | DB12332 | 851 | 1,619 | [
"DDInter1274",
"DDInter1626"
] | Nefazodone | Rucaparib | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
851,
24,
1619
]
],
[
[
851,
64,
222
],
[
222,
23,
1619
]
],
[
[
851,
25,
1135
],
[
1135,
23,
1619
]
],
[
[
851,
24,
309
],
[
309,
... | [
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutramin... | Nefazodone may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Nefazodone may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interactio... |
DB00277 | DB00365 | 1,031 | 839 | [
"DDInter1791",
"DDInter842"
] | Theophylline | Grepafloxacin | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Moderate | 1 | [
[
[
1031,
24,
839
]
],
[
[
1031,
63,
1684
],
[
1684,
24,
839
]
],
[
[
1031,
24,
659
],
[
659,
63,
839
]
],
[
[
1031,
23,
1096
],
[
1096,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Grepafloxacin"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Caffeine"
],
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Caffeine and Caffeine may cause a moderate interaction that could exacerbate diseases when taken with Grepafloxacin
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vil... |
DB00349 | DB01075 | 902 | 1,376 | [
"DDInter401",
"DDInter569"
] | Clobazam | Diphenhydramine | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
902,
24,
1376
]
],
[
[
902,
24,
649
],
[
649,
63,
1376
]
],
[
[
902,
24,
128
],
[
128,
24,
1376
]
],
[
[
902,
40,
998
],
[
998,
... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine a... |
DB06448 | DB12941 | 171 | 466 | [
"DDInter1087",
"DDInter481"
] | Lonafarnib | Darolutamide | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
171,
24,
466
]
],
[
[
171,
63,
1374
],
[
1374,
23,
466
]
],
[
[
171,
25,
1446
],
[
1446,
23,
466
]
],
[
[
171,
64,
600
],
[
600,
... | [
[
[
"Lonafarnib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Lonafarnib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
[... | Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Lonafarnib may lead to a major life threatening interaction when taken with Lanreotide and Lanreotide may caus... |
DB00443 | DB01170 | 251 | 1,150 | [
"DDInter195",
"DDInter846"
] | Betamethasone | Guanethidine | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem] | Moderate | 1 | [
[
[
251,
24,
1150
]
],
[
[
251,
6,
8374
],
[
8374,
45,
1150
]
],
[
[
251,
24,
1344
],
[
1344,
63,
1150
]
],
[
[
251,
1,
617
],
[
617,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guanethidine"
]
],
[
[
"Betamethasone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Com... | Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Guanethidine (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Guanethidine
Be... |
DB00264 | DB11827 | 88 | 433 | [
"DDInter1200",
"DDInter669"
] | Metoprolol | Ertugliflozin | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
88,
24,
433
]
],
[
[
88,
40,
1121
],
[
1121,
24,
433
]
],
[
[
88,
24,
959
],
[
959,
24,
433
]
],
[
[
88,
23,
1152
],
[
1152,
24,... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Metoprolol",
"{u} (Compound) resembles {v} (Compound)",
"Bisoprolol"
],
[
"Bisoprolol",
"{u} may cause a mode... | Metoprolol (Compound) resembles Bisoprolol (Compound) and Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that coul... |
DB00477 | DB11113 | 216 | 657 | [
"DDInter363",
"DDInter307"
] | Chlorpromazine | Castor oil | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
216,
24,
657
]
],
[
[
216,
24,
927
],
[
927,
63,
657
]
],
[
[
216,
24,
1491
],
[
1491,
24,
657
]
],
[
[
216,
25,
985
],
[
985,
2... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin... |
DB00683 | DB06282 | 1,382 | 516 | [
"DDInter1212",
"DDInter1053"
] | Midazolam | Levocetirizine | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
1382,
24,
516
]
],
[
[
1382,
62,
1031
],
[
1031,
23,
516
]
],
[
[
1382,
24,
1074
],
[
1074,
63,
516
]
],
[
[
1382,
63,
701
],
[
701,
... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Midazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Theophylline"
],
[
... | Midazolam may cause a minor interaction that can limit clinical effects when taken with Theophylline and Theophylline may cause a minor interaction that can limit clinical effects when taken with Levocetirizine
Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123 and Io... |
DB01021 | DB09104 | 674 | 286 | [
"DDInter1861",
"DDInter1118"
] | Trichlormethiazide | Magnesium hydroxide | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
674,
24,
286
]
],
[
[
674,
24,
401
],
[
401,
23,
286
]
],
[
[
674,
63,
355
],
[
355,
23,
286
]
],
[
[
674,
40,
1326
],
[
1326,
2... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pr... | Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken... |
DB00631 | DB01039 | 372 | 535 | [
"DDInter405",
"DDInter718"
] | Clofarabine | Fenofibrate | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993. | Moderate | 1 | [
[
[
372,
24,
535
]
],
[
[
372,
63,
831
],
[
831,
1,
535
]
],
[
[
372,
21,
28936
],
[
28936,
60,
535
]
],
[
[
372,
63,
522
],
[
522,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenofibrate"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indomethacin"
],
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) resembles Fenofibrate (Compound)
Clofarabine (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Fenofibrate (Compound)
Clofarabine may cause a mode... |
DB00227 | DB00736 | 1,463 | 660 | [
"DDInter1098",
"DDInter676"
] | Lovastatin | Esomeprazole | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Moderate | 1 | [
[
[
1463,
24,
660
]
],
[
[
1463,
24,
1215
],
[
1215,
40,
660
]
],
[
[
1463,
63,
837
],
[
837,
1,
660
]
],
[
[
1463,
6,
8374
],
[
8374,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esomeprazole"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Esomeprazole (Compound)
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Pantoprazole and Pantoprazole (Compound) resembles Esomeprazole... |
DB01072 | DB09481 | 915 | 460 | [
"DDInter129",
"DDInter1113"
] | Atazanavir | Magnesium carbonate | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
915,
24,
460
]
],
[
[
915,
64,
752
],
[
752,
23,
460
]
],
[
[
915,
25,
1468
],
[
1468,
23,
460
]
],
[
[
915,
25,
594
],
[
594,
2... | [
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cimetidine"
],
[
"C... | Atazanavir may lead to a major life threatening interaction when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Atazanavir may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a minor in... |
DB04575 | DB08882 | 35 | 1,281 | [
"DDInter1555",
"DDInter1070"
] | Quinestrol | Linagliptin | The 3-cyclopentyl ether of ethinyl estradiol. | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
35,
24,
1281
]
],
[
[
35,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
35,
63,
251
],
[
251,
24,
1281
]
],
[
[
35,
24,
1320
],
[
1320,
6... | [
[
[
"Quinestrol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Quinestrol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
[
... | Quinestrol may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Quinestrol may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone may cause a moderate interaction tha... |
DB00850 | DB06203 | 1,630 | 1,002 | [
"DDInter1432",
"DDInter51"
] | Perphenazine | Alogliptin | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
1630,
24,
1002
]
],
[
[
1630,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
1630,
6,
12523
],
[
12523,
45,
1002
]
],
[
[
1630,
21,
28778
],
[
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Perphenazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Alogliptin (Compound)
Perphenazine (Compound) causes Anaphylactic shock (Side Effe... |
DB11793 | DB15965 | 738 | 1,330 | [
"DDInter1297",
"DDInter1270"
] | Niraparib | Naxitamab | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Moderate | 1 | [
[
[
738,
24,
1330
]
],
[
[
738,
63,
1532
],
[
1532,
24,
1330
]
],
[
[
738,
24,
270
],
[
270,
24,
1330
]
],
[
[
738,
64,
375
],
[
375,
... | [
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naxitamab"
]
],
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[
... | Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab
Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizu... |
DB00218 | DB00305 | 1,176 | 377 | [
"DDInter1247",
"DDInter1232"
] | Moxifloxacin | Mitomycin | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Minor | 0 | [
[
[
1176,
23,
377
]
],
[
[
1176,
6,
3199
],
[
3199,
57,
377
]
],
[
[
1176,
21,
28680
],
[
28680,
60,
377
]
],
[
[
1176,
1,
246
],
[
246,
... | [
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mitomycin"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) binds {v} (Gene)",
"TOP2A"
],
[
"TOP2A",
"{u} (Gene) is downregulated by {v} (Comp... | Moxifloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Mitomycin (Compound)
Moxifloxacin (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Mitomycin (Compound)
Moxifloxacin (Compound) resembles Gatifloxacin (Compound) and Gatifloxacin may cause a minor interaction that ca... |
DB00184 | DB00501 | 763 | 752 | [
"DDInter1290",
"DDInter380"
] | Nicotine | Cimetidine | Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Minor | 0 | [
[
[
763,
23,
752
]
],
[
[
763,
6,
9752
],
[
9752,
45,
752
]
],
[
[
763,
21,
29134
],
[
29134,
60,
752
]
],
[
[
763,
23,
1684
],
[
1684,
... | [
[
[
"Nicotine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
]
],
[
[
"Nicotine",
"{u} (Compound) binds {v} (Gene)",
"SLC22A4"
],
[
"SLC22A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Nicotine (Compound) binds SLC22A4 (Gene) and SLC22A4 (Gene) is bound by Cimetidine (Compound)
Nicotine (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Cimetidine (Compound)
Nicotine may cause a minor interaction that can limit clinical effects when taken with Caffeine and Caffeine m... |
DB00059 | DB00598 | 1,560 | 1,523 | [
"DDInter1404",
"DDInter1013"
] | Pegaspargase | Labetalol | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Moderate | 1 | [
[
[
1560,
24,
1523
]
],
[
[
1560,
24,
935
],
[
935,
1,
1523
]
],
[
[
1560,
24,
1274
],
[
1274,
63,
1523
]
],
[
[
1560,
24,
578
],
[
578,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
[... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Labetalol (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction tha... |
DB00222 | DB00252 | 245 | 362 | [
"DDInter825",
"DDInter1460"
] | Glimepiride | Phenytoin | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Moderate | 1 | [
[
[
245,
24,
362
]
],
[
[
245,
24,
126
],
[
126,
63,
362
]
],
[
[
245,
24,
97
],
[
97,
40,
362
]
],
[
[
245,
6,
6017
],
[
6017,
45,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin ... |
DB00095 | DB12498 | 66 | 76 | [
"DDInter623",
"DDInter1238"
] | Efalizumab | Mogamulizumab | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Mogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become canc... | Moderate | 1 | [
[
[
66,
24,
76
]
],
[
[
66,
23,
1461
],
[
1461,
23,
76
]
],
[
[
66,
24,
1531
],
[
1531,
24,
76
]
],
[
[
66,
63,
58
],
[
58,
24,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mogamulizumab"
]
],
[
[
"Efalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Efalizumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Mogamulizumab
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinu... |
DB00570 | DB11569 | 147 | 1,093 | [
"DDInter1936",
"DDInter1003"
] | Vinblastine | Ixekizumab | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Moderate | 1 | [
[
[
147,
24,
1093
]
],
[
[
147,
63,
1461
],
[
1461,
23,
1093
]
],
[
[
147,
63,
66
],
[
66,
24,
1093
]
],
[
[
147,
24,
496
],
[
496,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ixekizumab
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizum... |
DB01166 | DB11703 | 477 | 405 | [
"DDInter379",
"DDInter9"
] | Cilostazol | Acalabrutinib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
477,
25,
405
]
],
[
[
477,
63,
383
],
[
383,
24,
405
]
],
[
[
477,
24,
643
],
[
643,
24,
405
]
],
[
[
477,
25,
982
],
[
982,
63,... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
],
[
... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00069 | DB01100 | 367 | 1,568 | [
"DDInter946",
"DDInter1470"
] | Interferon alfacon-1 | Pimozide | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
367,
24,
1568
]
],
[
[
367,
24,
112
],
[
112,
23,
1568
]
],
[
[
367,
24,
1503
],
[
1503,
24,
1568
]
],
[
[
367,
63,
1451
],
[
1451,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronida... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pimozide
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00655 | DB08907 | 559 | 1,344 | [
"DDInter682",
"DDInter280"
] | Estrone | Canagliflozin | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
559,
24,
1344
]
],
[
[
559,
24,
549
],
[
549,
1,
1344
]
],
[
[
559,
6,
4973
],
[
4973,
45,
1344
]
],
[
[
559,
21,
28873
],
[
28873,
... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
[
... | Estrone may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Estrone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Canagliflozin (Compound)
Estrone (Compound) causes Pancreatitis (Side Effect) and Pancr... |
DB00163 | DB00544 | 1,461 | 970 | [
"DDInter1943",
"DDInter757"
] | Vitamin E | Fluorouracil | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Moderate | 1 | [
[
[
1461,
24,
970
]
],
[
[
1461,
24,
132
],
[
132,
1,
970
]
],
[
[
1461,
7,
2384
],
[
2384,
46,
970
]
],
[
[
1461,
18,
3307
],
[
3307,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluorouracil"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Uracil mustard"
],
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Uracil mustard and Uracil mustard (Compound) resembles Fluorouracil (Compound)
Vitamin E (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Fluorouracil (Compound)
Vitamin E (Compound) downregulates PTPRO (Gene) ... |
DB00553 | DB00808 | 92 | 1,605 | [
"DDInter1177",
"DDInter916"
] | Methoxsalen | Indapamide | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Moderate | 1 | [
[
[
92,
24,
1605
]
],
[
[
92,
63,
811
],
[
811,
1,
1605
]
],
[
[
92,
6,
8374
],
[
8374,
45,
1605
]
],
[
[
92,
21,
29135
],
[
29135,
... | [
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
]
],
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
],
[
... | Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound)
Methoxsalen (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Indapamide (Compound)
Methoxsalen (Compound) causes Blister (Side Effect) and Blister ... |
DB01249 | DB06704 | 258 | 247 | [
"DDInter958",
"DDInter952"
] | Iodixanol | Iobenguane (I-131) | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Major | 2 | [
[
[
258,
25,
247
]
],
[
[
258,
21,
28787
],
[
28787,
60,
247
]
],
[
[
258,
64,
1199
],
[
1199,
24,
247
]
],
[
[
258,
24,
242
],
[
242,
... | [
[
[
"Iodixanol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Iodixanol",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is caused by {v} (Comp... | Iodixanol may lead to a major life threatening interaction when taken with Iobenguane
Iodixanol (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iobenguane (Compound)
Iodixanol may lead to a major life threatening interaction when taken with Ibandronate and Ibandronate may cause a mo... |
DB00108 | DB08886 | 1,066 | 637 | [
"DDInter1268",
"DDInter126"
] | Natalizumab | Asparaginase Erwinia chrysanthemi | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
1066,
24,
637
]
],
[
[
1066,
64,
491
],
[
491,
24,
637
]
],
[
[
1066,
25,
250
],
[
250,
63,
637
]
],
[
[
1066,
25,
167
],
[
167,
... | [
[
[
"Natalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Peginterferon alf... | Natalizumab may lead to a major life threatening interaction when taken with Peginterferon alfa-2a and Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Natalizumab may lead to a major life threatening interaction when taken with Blin... |
DB00578 | DB01024 | 703 | 1,096 | [
"DDInter295",
"DDInter1252"
] | Carbenicillin | Mycophenolic acid | Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function. | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Moderate | 1 | [
[
[
703,
24,
1096
]
],
[
[
703,
21,
28779
],
[
28779,
60,
1096
]
],
[
[
703,
1,
1124
],
[
1124,
63,
1096
]
],
[
[
703,
23,
609
],
[
609,
... | [
[
[
"Carbenicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Carbenicillin",
"{u} (Compound) causes {v} (Side Effect)",
"Dry mouth"
],
[
"Dry mouth",
"{u} (Side Ef... | Carbenicillin (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Mycophenolic acid (Compound)
Carbenicillin (Compound) resembles Cefamandole (Compound) and Cefamandole may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid
Carbenicillin may caus... |
DB00682 | DB08820 | 126 | 1,478 | [
"DDInter1951",
"DDInter997"
] | Warfarin | Ivacaftor | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
126,
24,
1478
]
],
[
[
126,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
126,
35,
307
],
[
307,
23,
1478
]
],
[
[
126,
24,
318
],
[
318,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Warfarin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Warfarin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Warfarin (Compound) resembles Modafinil (Compound) and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects... |
DB00774 | DB01105 | 1,577 | 222 | [
"DDInter889",
"DDInter1665"
] | Hydroflumethiazide | Sibutramine | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1577,
24,
222
]
],
[
[
1577,
18,
2114
],
[
2114,
57,
222
]
],
[
[
1577,
21,
28852
],
[
28852,
60,
222
]
],
[
[
1577,
24,
659
],
[
659,... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Hydroflumethiazide",
"{u} (Compound) downregulates {v} (Gene)",
"MIF"
],
[
"MIF",
"{u} (Gene) is downre... | Hydroflumethiazide (Compound) downregulates MIF (Gene) and MIF (Gene) is downregulated by Sibutramine (Compound)
Hydroflumethiazide (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Sibutramine (Compound)
Hydroflumethiazide may cause a moderate interaction that could exacerbate diseas... |
DB06788 | DB11915 | 1,616 | 1,293 | [
"DDInter864",
"DDInter1909"
] | Histrelin | Valbenazine | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
1616,
24,
1293
]
],
[
[
1616,
62,
112
],
[
112,
23,
1293
]
],
[
[
1616,
63,
401
],
[
401,
24,
1293
]
],
[
[
1616,
24,
603
],
[
603,
... | [
[
[
"Histrelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Histrelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Histrelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Pro... |
DB00647 | DB00938 | 675 | 455 | [
"DDInter528",
"DDInter1635"
] | Dextropropoxyphene | Salmeterol | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
675,
24,
455
]
],
[
[
675,
24,
688
],
[
688,
63,
455
]
],
[
[
675,
40,
371
],
[
371,
63,
455
]
],
[
[
675,
6,
6799
],
[
6799,
45... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"... | Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Dextropropoxyphene (Compound) resembles Propafenone (Compound) and Propafenone may cause a moderate inte... |
DB00197 | DB06589 | 1,324 | 1,250 | [
"DDInter1881",
"DDInter1400"
] | Troglitazone | Pazopanib | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1324,
24,
1250
]
],
[
[
1324,
24,
307
],
[
307,
23,
1250
]
],
[
[
1324,
24,
907
],
[
907,
62,
1250
]
],
[
[
1324,
24,
1630
],
[
1630,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Pazopanib
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Doravirine and Doravir... |
DB01124 | DB09038 | 1,411 | 1,450 | [
"DDInter1828",
"DDInter636"
] | Tolbutamide | Empagliflozin | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1411,
24,
1450
]
],
[
[
1411,
62,
1103
],
[
1103,
23,
1450
]
],
[
[
1411,
63,
461
],
[
461,
24,
1450
]
],
[
[
1411,
24,
659
],
[
659,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Tolbutamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
[... | Tolbutamide may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Empagliflozin
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol ... |
DB06626 | DB09054 | 263 | 384 | [
"DDInter147",
"DDInter905"
] | Axitinib | Idelalisib | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
263,
25,
384
]
],
[
[
263,
24,
1627
],
[
1627,
62,
384
]
],
[
[
263,
24,
555
],
[
555,
23,
384
]
],
[
[
263,
64,
307
],
[
307,
2... | [
[
[
"Axitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
[
"Cannabidiol",... | Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Netupitant and Netupitant... |
DB00175 | DB00526 | 681 | 1,555 | [
"DDInter1509",
"DDInter1355"
] | Pravastatin | Oxaliplatin | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
681,
24,
1555
]
],
[
[
681,
6,
17404
],
[
17404,
45,
1555
]
],
[
[
681,
24,
384
],
[
384,
63,
1555
]
],
[
[
681,
24,
10
],
[
10,
... | [
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Pravastatin",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)"... | Pravastatin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Oxaliplatin (Compound)
Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Pravastatin may ... |
DB00598 | DB00804 | 1,523 | 1,507 | [
"DDInter1013",
"DDInter543"
] | Labetalol | Dicyclomine | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Moderate | 1 | [
[
[
1523,
24,
1507
]
],
[
[
1523,
21,
28817
],
[
28817,
60,
1507
]
],
[
[
1523,
40,
1188
],
[
1188,
63,
1507
]
],
[
[
1523,
63,
475
],
[
4... | [
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
]
],
[
[
"Labetalol",
"{u} (Compound) causes {v} (Side Effect)",
"Vision blurred"
],
[
"Vision blurred",
"{u} (Side Effect... | Labetalol (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Dicyclomine (Compound)
Labetalol (Compound) resembles Arbutamine (Compound) and Arbutamine may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine
Labetalol may cause a moderate int... |
DB01377 | DB13257 | 1,283 | 260 | [
"DDInter1119",
"DDInter727"
] | Magnesium oxide | Ferrous sulfate anhydrous | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age. This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation of erythrocytes, also known as red blood cells. Ferrous sulfate is a sy... | Moderate | 1 | [
[
[
1283,
24,
260
]
],
[
[
1283,
62,
752
],
[
752,
23,
260
]
],
[
[
1283,
63,
1096
],
[
1096,
23,
260
]
],
[
[
1283,
63,
1620
],
[
1620,
... | [
[
[
"Magnesium oxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous sulfate anhydrous"
]
],
[
[
"Magnesium oxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cime... | Magnesium oxide may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Ferrous sulfate anhydrous
Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB01009 | DB06228 | 935 | 792 | [
"DDInter1009",
"DDInter1609"
] | Ketoprofen | Rivaroxaban | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
935,
25,
792
]
],
[
[
935,
18,
5901
],
[
5901,
57,
792
]
],
[
[
935,
21,
28703
],
[
28703,
60,
792
]
],
[
[
935,
40,
307
],
[
307,
... | [
[
[
"Ketoprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Ketoprofen",
"{u} (Compound) downregulates {v} (Gene)",
"GJA1"
],
[
"GJA1",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Ketoprofen (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Rivaroxaban (Compound)
Ketoprofen (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Ketoprofen (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction t... |
DB01222 | DB06643 | 617 | 1,136 | [
"DDInter246",
"DDInter500"
] | Budesonide | Denosumab | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
617,
24,
1136
]
],
[
[
617,
24,
1213
],
[
1213,
24,
1136
]
],
[
[
617,
24,
1316
],
[
1316,
63,
1136
]
],
[
[
617,
63,
1419
],
[
1419,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Durvalumab and Durvaluma... |
DB00370 | DB11979 | 1,251 | 1,320 | [
"DDInter1230",
"DDInter625"
] | Mirtazapine | Elagolix | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1251,
24,
1320
]
],
[
[
1251,
24,
1297
],
[
1297,
24,
1320
]
],
[
[
1251,
25,
877
],
[
877,
63,
1320
]
],
[
[
1251,
24,
484
],
[
484,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
],
[
... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and Osilodrostat may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Mirtazapine may lead to a major life threatening interaction when taken with Macimorelin and Macimorelin may ... |
DB00852 | DB01261 | 1,445 | 170 | [
"DDInter1545",
"DDInter1679"
] | Pseudoephedrine | Sitagliptin | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1445,
24,
170
]
],
[
[
1445,
21,
28921
],
[
28921,
60,
170
]
],
[
[
1445,
24,
52
],
[
52,
62,
170
]
],
[
[
1445,
63,
1252
],
[
1252,
... | [
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Pseudoephedrine",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effe... | Pseudoephedrine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Sitagliptin (Compound)
Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when taken w... |
DB00443 | DB14443 | 251 | 987 | [
"DDInter195",
"DDInter1931"
] | Betamethasone | Vibrio cholerae CVD 103-HgR strain live antigen | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
251,
24,
987
]
],
[
[
251,
1,
1220
],
[
1220,
24,
987
]
],
[
[
251,
24,
351
],
[
351,
24,
987
]
],
[
[
251,
63,
305
],
[
305,
24... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Betamethasone",
"{u} (Compound) resembles {v} (Compound)",
"Dexamethasone"
],
[
... | Betamethasone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Riboc... |
DB00526 | DB00987 | 1,555 | 1,224 | [
"DDInter1355",
"DDInter460"
] | Oxaliplatin | Cytarabine | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Moderate | 1 | [
[
[
1555,
24,
1224
]
],
[
[
1555,
24,
1585
],
[
1585,
1,
1224
]
],
[
[
1555,
6,
8803
],
[
8803,
45,
1224
]
],
[
[
1555,
24,
872
],
[
872,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cytarabine"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Adenosine"
],
[
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Adenosine and Adenosine (Compound) resembles Cytarabine (Compound)
Oxaliplatin (Compound) binds SLC22A2 (Gene) and SLC22A2 (Gene) is bound by Cytarabine (Compound)
Oxaliplatin may cause a moderate interaction that could exacerba... |
DB00060 | DB00598 | 912 | 1,523 | [
"DDInter947",
"DDInter1013"
] | Interferon beta-1a | Labetalol | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Moderate | 1 | [
[
[
912,
24,
1523
]
],
[
[
912,
24,
935
],
[
935,
1,
1523
]
],
[
[
912,
24,
1274
],
[
1274,
63,
1523
]
],
[
[
912,
24,
126
],
[
126,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Labetalol (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate int... |
DB00501 | DB01023 | 752 | 409 | [
"DDInter380",
"DDInter716"
] | Cimetidine | Felodipine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Moderate | 1 | [
[
[
752,
24,
409
]
],
[
[
752,
24,
1081
],
[
1081,
40,
409
]
],
[
[
752,
63,
1428
],
[
1428,
1,
409
]
],
[
[
752,
6,
3486
],
[
3486,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nicardipine"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Felodipine (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Felodipine (Compound... |
DB00471 | DB06414 | 201 | 655 | [
"DDInter1242",
"DDInter703"
] | Montelukast | Etravirine | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
201,
24,
655
]
],
[
[
201,
6,
6017
],
[
6017,
45,
655
]
],
[
[
201,
21,
28740
],
[
28740,
60,
655
]
],
[
[
201,
63,
1101
],
[
1101,
... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Montelukast",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)... | Montelukast (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Etravirine (Compound)
Montelukast (Compound) causes Disturbance in attention (Side Effect) and Disturbance in attention (Side Effect) is caused by Etravirine (Compound)
Montelukast may cause a moderate interaction that could exacerbate diseases wh... |
DB01105 | DB12364 | 222 | 1,421 | [
"DDInter1665",
"DDInter200"
] | Sibutramine | Betrixaban | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
222,
24,
1421
]
],
[
[
222,
62,
1091
],
[
1091,
24,
1421
]
],
[
[
222,
24,
1017
],
[
1017,
24,
1421
]
],
[
[
222,
64,
529
],
[
529,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Sibutramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amprenavir"
],
[
... | Sibutramine may cause a minor interaction that can limit clinical effects when taken with Amprenavir and Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlat... |
DB01118 | DB09020 | 33 | 28 | [
"DDInter76",
"DDInter212"
] | Amiodarone | Bisacodyl | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
33,
24,
28
]
],
[
[
33,
7,
5998
],
[
5998,
46,
28
]
],
[
[
33,
6,
9842
],
[
9842,
46,
28
]
],
[
[
33,
7,
5509
],
[
5509,
57,
... | [
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Amiodarone",
"{u} (Compound) upregulates {v} (Gene)",
"HMOX1"
],
[
"HMOX1",
"{u} (Gene) is upregulated by {v} (Co... | Amiodarone (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Bisacodyl (Compound)
Amiodarone (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is upregulated by Bisacodyl (Compound)
Amiodarone (Compound) upregulates FDFT1 (Gene) and FDFT1 (Gene) is downregulated by Bisacodyl (Compound)
Amiodarone (C... |
DB00526 | DB05273 | 1,555 | 507 | [
"DDInter1355",
"DDInter1638"
] | Oxaliplatin | Samarium (153Sm) lexidronam | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Major | 2 | [
[
[
1555,
25,
507
]
],
[
[
1555,
24,
789
],
[
789,
24,
507
]
],
[
[
1555,
24,
270
],
[
270,
63,
507
]
],
[
[
1555,
24,
110
],
[
110,
... | [
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Samarium (153Sm) lexidronam"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Foscarnet"
],
[... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet and Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Ocre... |
DB06754 | DB09293 | 707 | 116 | [
"DDInter471",
"DDInter954"
] | Danaparoid | Iodide I-131 | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans. The active constituents are heparan, dermatan and, and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity tha... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
707,
24,
116
]
],
[
[
707,
24,
1004
],
[
1004,
63,
116
]
],
[
[
707,
25,
365
],
[
365,
24,
116
]
],
[
[
707,
64,
834
],
[
834,
2... | [
[
[
"Danaparoid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Danaparoid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
],... | Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl salicylate may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Danaparoid may lead to a major life threatening interaction when taken with Dalteparin and Dalte... |
DB11730 | DB12500 | 351 | 283 | [
"DDInter1588",
"DDInter714"
] | Ribociclib | Fedratinib | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Minor | 0 | [
[
[
351,
23,
283
]
],
[
[
351,
62,
271
],
[
271,
23,
283
]
],
[
[
351,
23,
907
],
[
907,
23,
283
]
],
[
[
351,
23,
466
],
[
466,
62,... | [
[
[
"Ribociclib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fedratinib"
]
],
[
[
"Ribociclib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
... | Ribociclib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Ribociclib may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravirine m... |
DB08826 | DB15035 | 1,292 | 503 | [
"DDInter489",
"DDInter1959"
] | Deferiprone | Zanubrutinib | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1292,
25,
503
]
],
[
[
1292,
25,
951
],
[
951,
24,
503
]
],
[
[
1292,
64,
66
],
[
66,
24,
503
]
],
[
[
1292,
64,
39
],
[
39,
25,... | [
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
],
[
"Palbociclib",
... | Deferiprone may lead to a major life threatening interaction when taken with Palbociclib and Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Deferiprone may lead to a major life threatening interaction when taken with Efalizumab and Efalizumab may cause a moderat... |
DB00574 | DB01168 | 121 | 1,053 | [
"DDInter717",
"DDInter1526"
] | Fenfluramine | Procarbazine | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Major | 2 | [
[
[
121,
25,
1053
]
],
[
[
121,
24,
848
],
[
848,
40,
1053
]
],
[
[
121,
24,
126
],
[
126,
23,
1053
]
],
[
[
121,
24,
480
],
[
480,
... | [
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procarbazine"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
"Ibupr... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limi... |
DB01394 | DB06273 | 1,554 | 980 | [
"DDInter431",
"DDInter1824"
] | Colchicine | Tocilizumab | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
1554,
24,
980
]
],
[
[
1554,
24,
309
],
[
309,
24,
980
]
],
[
[
1554,
63,
973
],
[
973,
24,
980
]
],
[
[
1554,
24,
850
],
[
850,
... | [
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
[
... | Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Pac... |
DB00916 | DB08899 | 112 | 129 | [
"DDInter1202",
"DDInter649"
] | Metronidazole | Enzalutamide | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Minor | 0 | [
[
[
112,
23,
129
]
],
[
[
112,
23,
918
],
[
918,
1,
129
]
],
[
[
112,
6,
8374
],
[
8374,
45,
129
]
],
[
[
112,
21,
28703
],
[
28703,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enzalutamide"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bicalutamide"
],
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Metronidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Metronidazole (Compound) causes Pruritus (Side Effect)... |
DB01036 | DB01087 | 211 | 1,520 | [
"DDInter1832",
"DDInter1520"
] | Tolterodine | Primaquine | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Minor | 0 | [
[
[
211,
23,
1520
]
],
[
[
211,
23,
1487
],
[
1487,
64,
1520
]
],
[
[
211,
6,
12523
],
[
12523,
45,
1520
]
],
[
[
211,
21,
28900
],
[
2890... | [
[
[
"Tolterodine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Primaquine"
]
],
[
[
"Tolterodine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroxychloroquine"
],
... | Tolterodine may cause a minor interaction that can limit clinical effects when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Tolterodine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound)
Tolterodine (Comp... |
DB01234 | DB06702 | 1,220 | 573 | [
"DDInter513",
"DDInter731"
] | Dexamethasone | Fesoterodine | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
1220,
24,
573
]
],
[
[
1220,
63,
494
],
[
494,
1,
573
]
],
[
[
1220,
6,
12523
],
[
12523,
45,
573
]
],
[
[
1220,
21,
28921
],
[
28921,... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
]... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Fesoterodine (Compound)
Dexamethasone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fesoterodine (Compound)
Dexamethasone (Compound) causes Dizziness (Side Effe... |
DB01225 | DB06228 | 500 | 792 | [
"DDInter645",
"DDInter1609"
] | Enoxaparin | Rivaroxaban | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
500,
25,
792
]
],
[
[
500,
6,
2832
],
[
2832,
45,
792
]
],
[
[
500,
21,
28703
],
[
28703,
60,
792
]
],
[
[
500,
23,
944
],
[
944,
... | [
[
[
"Enoxaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Enoxaparin",
"{u} (Compound) binds {v} (Gene)",
"F10"
],
[
"F10",
"{u} (Gene) is bound by {v} (Compound)",
"Rivaroxaban"... | Enoxaparin (Compound) binds F10 (Gene) and F10 (Gene) is bound by Rivaroxaban (Compound)
Enoxaparin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Enoxaparin may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may... |
DB00703 | DB01284 | 997 | 1,042 | [
"DDInter1167",
"DDInter1782"
] | Methazolamide | Tetracosactide | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
997,
24,
1042
]
],
[
[
997,
24,
455
],
[
455,
23,
1042
]
],
[
[
997,
24,
659
],
[
659,
62,
1042
]
],
[
[
997,
24,
761
],
[
761,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]... | Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol an... |
DB00501 | DB00909 | 752 | 306 | [
"DDInter380",
"DDInter1971"
] | Cimetidine | Zonisamide | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Moderate | 1 | [
[
[
752,
24,
306
]
],
[
[
752,
6,
8374
],
[
8374,
45,
306
]
],
[
[
752,
18,
3682
],
[
3682,
57,
306
]
],
[
[
752,
21,
28691
],
[
28691,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zonisamide"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Cimetidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zonisamide (Compound)
Cimetidine (Compound) downregulates PIN1 (Gene) and PIN1 (Gene) is downregulated by Zonisamide (Compound)
Cimetidine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Zonisamide (Compound)
Ci... |
DB00697 | DB00792 | 876 | 832 | [
"DDInter1821",
"DDInter1878"
] | Tizanidine | Tripelennamine | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
876,
24,
832
]
],
[
[
876,
24,
100
],
[
100,
63,
832
]
],
[
[
876,
24,
649
],
[
649,
1,
832
]
],
[
[
876,
63,
1594
],
[
1594,
24... | [
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
],... | Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Clofeda... |
DB00321 | DB00662 | 21 | 717 | [
"DDInter78",
"DDInter1873"
] | Amitriptyline | Trimethobenzamide | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Moderate | 1 | [
[
[
21,
24,
717
]
],
[
[
21,
25,
1425
],
[
1425,
40,
717
]
],
[
[
21,
21,
29648
],
[
29648,
60,
717
]
],
[
[
21,
35,
1594
],
[
1594,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethobenzamide"
]
],
[
[
"Amitriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisapride"
],
[
... | Amitriptyline may lead to a major life threatening interaction when taken with Cisapride and Cisapride (Compound) resembles Trimethobenzamide (Compound)
Amitriptyline (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Trimethobenzamide (Compound)
Amitriptyline (Compound) resemb... |
DB00331 | DB00440 | 1,645 | 1,548 | [
"DDInter1164",
"DDInter1874"
] | Metformin | Trimethoprim | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in comb... | Moderate | 1 | [
[
[
1645,
24,
1548
]
],
[
[
1645,
21,
29232
],
[
29232,
60,
1548
]
],
[
[
1645,
24,
473
],
[
473,
63,
1548
]
],
[
[
1645,
21,
29232
],
[
2... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethoprim"
]
],
[
[
"Metformin",
"{u} (Compound) causes {v} (Side Effect)",
"Urticaria"
],
[
"Urticaria",
"{u} (Side Effect) is caus... | Metformin (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Trimethoprim (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Trime... |
DB01611 | DB09020 | 1,487 | 28 | [
"DDInter893",
"DDInter212"
] | Hydroxychloroquine | Bisacodyl | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1487,
24,
28
]
],
[
[
1487,
21,
28666
],
[
28666,
60,
28
]
],
[
[
1487,
64,
739
],
[
739,
24,
28
]
],
[
[
1487,
25,
540
],
[
540,
... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Hydroxychloroquine",
"{u} (Compound) causes {v} (Side Effect)",
"Nervous system disorder"
],
[
"Nervous system ... | Hydroxychloroquine (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Bisacodyl (Compound)
Hydroxychloroquine may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin may cause a moderate interaction that could exacerbate ... |
DB00023 | DB06688 | 305 | 1,430 | [
"DDInter127",
"DDInter1677"
] | Asparaginase Escherichia coli | Sipuleucel-T | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
305,
24,
1430
]
],
[
[
305,
24,
175
],
[
175,
24,
1430
]
],
[
[
305,
25,
676
],
[
676,
63,
1430
]
],
[
[
305,
63,
491
],
[
491,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Asparaginase Escherichia coli may lead to a major life threatening interaction when t... |
DB00655 | DB12267 | 559 | 1,476 | [
"DDInter682",
"DDInter233"
] | Estrone | Brigatinib | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
559,
24,
1476
]
],
[
[
559,
24,
629
],
[
629,
24,
1476
]
],
[
[
559,
63,
176
],
[
176,
24,
1476
]
],
[
[
559,
24,
1385
],
[
1385,
... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
],
[
"Si... | Estrone may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Estrone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin ... |
DB00196 | DB11978 | 600 | 124 | [
"DDInter743",
"DDInter822"
] | Fluconazole | Glasdegib | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
600,
24,
124
]
],
[
[
600,
25,
1135
],
[
1135,
23,
124
]
],
[
[
600,
23,
1247
],
[
1247,
23,
124
]
],
[
[
600,
23,
466
],
[
466,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol"... | Fluconazole may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may... |
DB01133 | DB13749 | 1,104 | 1,473 | [
"DDInter1808",
"DDInter1116"
] | Tiludronic acid | Magnesium gluconate | Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and [clodronic acid].[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described ... | Magnesium gluconate is a magnesium salt of gluconate. It demonstrates the highest oral bioavailability of magnesium salts and is used as a mineral supplement. Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to other food products, available as a dietary supplement and used as an... | Moderate | 1 | [
[
[
1104,
24,
1473
]
],
[
[
1104,
63,
544
],
[
544,
24,
1473
]
],
[
[
1104,
24,
853
],
[
853,
24,
1473
]
],
[
[
1104,
63,
544
],
[
544,
... | [
[
[
"Tiludronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium gluconate"
]
],
[
[
"Tiludronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesiu... | Tiludronic acid may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate and Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium gluconate
Tiludronic acid may cause a moderate interaction that could exacerbate diseases when... |
DB01176 | DB01221 | 537 | 1,190 | [
"DDInter453",
"DDInter1007"
] | Cyclizine | Ketamine | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic... | Moderate | 1 | [
[
[
537,
24,
1190
]
],
[
[
537,
6,
6017
],
[
6017,
45,
1190
]
],
[
[
537,
21,
28719
],
[
28719,
60,
1190
]
],
[
[
537,
24,
407
],
[
407,
... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketamine"
]
],
[
[
"Cyclizine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Cyclizine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ketamine (Compound)
Cyclizine (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Ketamine (Compound)
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate... |
DB00451 | DB11126 | 542 | 900 | [
"DDInter1064",
"DDInter276"
] | Levothyroxine | Calcium gluconate | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Moderate | 1 | [
[
[
542,
24,
900
]
],
[
[
542,
23,
729
],
[
729,
24,
900
]
],
[
[
542,
40,
624
],
[
624,
24,
900
]
],
[
[
542,
62,
461
],
[
461,
24,... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Penbutolol"
... | Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Penbutolol and Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Levothyroxine (Compound) resembles Liotrix (Compound) and Liotrix may cause a moderate interaction that ... |
DB00023 | DB01067 | 305 | 959 | [
"DDInter127",
"DDInter826"
] | Asparaginase Escherichia coli | Glipizide | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
305,
24,
959
]
],
[
[
305,
24,
245
],
[
245,
40,
959
]
],
[
[
305,
24,
1411
],
[
1411,
1,
959
]
],
[
[
305,
24,
1551
],
[
1551,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (C... |
DB00738 | DB00836 | 485 | 543 | [
"DDInter1420",
"DDInter1088"
] | Pentamidine | Loperamide | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
485,
24,
543
]
],
[
[
485,
63,
675
],
[
675,
24,
543
]
],
[
[
485,
64,
1300
],
[
1300,
24,
543
]
],
[
[
485,
6,
8374
],
[
8374,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
]... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Pentamidine may lead to a major life threatening interaction when taken with Haloperidol and Ha... |
DB00637 | DB12141 | 1,557 | 971 | [
"DDInter128",
"DDInter817"
] | Astemizole | Gilteritinib | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1557,
24,
971
]
],
[
[
1557,
23,
1247
],
[
1247,
23,
971
]
],
[
[
1557,
24,
485
],
[
485,
24,
971
]
],
[
[
1557,
24,
730
],
[
730,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Astemizole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Astemizole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine... |
DB01082 | DB11071 | 1,448 | 1,004 | [
"DDInter1713",
"DDInter1449"
] | Streptomycin | Phenyl salicylate | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
1448,
24,
1004
]
],
[
[
1448,
63,
837
],
[
837,
23,
1004
]
],
[
[
1448,
24,
101
],
[
101,
23,
1004
]
],
[
[
1448,
35,
416
],
[
416,
... | [
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pantoprazole"
... | Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Pantoprazole and Pantoprazole may cause a minor interaction that can limit clinical effects when taken with Phenyl salicylate
Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Dexlanso... |
DB00316 | DB09054 | 474 | 384 | [
"DDInter14",
"DDInter905"
] | Acetaminophen | Idelalisib | Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the ... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
474,
24,
384
]
],
[
[
474,
63,
305
],
[
305,
24,
384
]
],
[
[
474,
24,
322
],
[
322,
24,
384
]
],
[
[
474,
24,
1619
],
[
1619,
6... | [
[
[
"Acetaminophen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Acetaminophen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escheric... | Acetaminophen may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Acetaminophen may cause a moderate interaction that could exacerbate di... |
DB01101 | DB10343 | 60 | 962 | [
"DDInter285",
"DDInter160"
] | Capecitabine | Bacillus calmette-guerin substrain tice live antigen | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
60,
25,
962
]
],
[
[
60,
64,
1057
],
[
1057,
25,
962
]
],
[
[
60,
24,
270
],
[
270,
64,
962
]
],
[
[
60,
24,
1362
],
[
1362,
25,... | [
[
[
"Capecitabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Capecitabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"... | Capecitabine may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Ocrel... |
DB00470 | DB00722 | 530 | 743 | [
"DDInter601",
"DDInter1079"
] | Dronabinol | Lisinopril | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | Moderate | 1 | [
[
[
530,
24,
743
]
],
[
[
530,
24,
610
],
[
610,
40,
743
]
],
[
[
530,
24,
1638
],
[
1638,
1,
743
]
],
[
[
530,
6,
4973
],
[
4973,
4... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Lisinopril (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Lisinopril (Compound... |
DB00060 | DB00238 | 912 | 188 | [
"DDInter947",
"DDInter1285"
] | Interferon beta-1a | Nevirapine | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Moderate | 1 | [
[
[
912,
24,
188
]
],
[
[
912,
24,
168
],
[
168,
23,
188
]
],
[
[
912,
24,
1101
],
[
1101,
62,
188
]
],
[
[
912,
24,
1374
],
[
1374,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nevirapine"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Nevirapine
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Bexarot... |
DB01105 | DB13928 | 222 | 1,385 | [
"DDInter1665",
"DDInter1660"
] | Sibutramine | Semaglutide | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
222,
24,
1385
]
],
[
[
222,
25,
1399
],
[
1399,
63,
1385
]
],
[
[
222,
62,
839
],
[
839,
24,
1385
]
],
[
[
222,
24,
280
],
[
280,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lithium carbonate"
],
[
"... | Sibutramine may lead to a major life threatening interaction when taken with Lithium carbonate and Lithium carbonate may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Sibutramine may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin and Gre... |
DB00196 | DB14730 | 600 | 1,412 | [
"DDInter743",
"DDInter264"
] | Fluconazole | Calaspargase pegol | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
600,
24,
1412
]
],
[
[
600,
24,
792
],
[
792,
24,
1412
]
],
[
[
600,
25,
1347
],
[
1347,
24,
1412
]
],
[
[
600,
23,
14
],
[
14,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban and Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Fluconazole may lead to a major life threatening interaction when taken with Clopidogrel and Clopidog... |
DB00188 | DB01261 | 168 | 170 | [
"DDInter222",
"DDInter1679"
] | Bortezomib | Sitagliptin | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
168,
24,
170
]
],
[
[
168,
6,
3486
],
[
3486,
45,
170
]
],
[
[
168,
7,
7849
],
[
7849,
57,
170
]
],
[
[
168,
18,
4112
],
[
4112,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Bortezomib",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)"... | Bortezomib (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sitagliptin (Compound)
Bortezomib (Compound) upregulates FRS2 (Gene) and FRS2 (Gene) is downregulated by Sitagliptin (Compound)
Bortezomib (Compound) downregulates AURKB (Gene) and AURKB (Gene) is downregulated by Sitagliptin (Compound)
Bortezomib ... |
DB00250 | DB00446 | 10 | 597 | [
"DDInter475",
"DDInter351"
] | Dapsone | Chloramphenicol | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Moderate | 1 | [
[
[
10,
24,
597
]
],
[
[
10,
6,
7524
],
[
7524,
45,
597
]
],
[
[
10,
18,
4930
],
[
4930,
57,
597
]
],
[
[
10,
21,
28745
],
[
28745,
... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
]
],
[
[
"Dapsone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
... | Dapsone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Chloramphenicol (Compound)
Dapsone (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Chloramphenicol (Compound)
Dapsone (Compound) causes Neuropathy peripheral (Side Effect) and Neuropathy peripheral (Side Effect) is caused by Chl... |
DB00719 | DB01036 | 1,219 | 211 | [
"DDInter149",
"DDInter1832"
] | Azatadine | Tolterodine | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Moderate | 1 | [
[
[
1219,
24,
211
]
],
[
[
1219,
24,
358
],
[
358,
40,
211
]
],
[
[
1219,
63,
494
],
[
494,
40,
211
]
],
[
[
1219,
63,
128
],
[
128,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine (Compound) resembles Tolterodine (Compound)
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Tolterodine (Co... |
DB00712 | DB00927 | 1,274 | 1,559 | [
"DDInter763",
"DDInter712"
] | Flurbiprofen | Famotidine | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Minor | 0 | [
[
[
1274,
23,
1559
]
],
[
[
1274,
18,
4930
],
[
4930,
57,
1559
]
],
[
[
1274,
21,
28826
],
[
28826,
60,
1559
]
],
[
[
1274,
64,
886
],
[
8... | [
[
[
"Flurbiprofen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Famotidine"
]
],
[
[
"Flurbiprofen",
"{u} (Compound) downregulates {v} (Gene)",
"DLD"
],
[
"DLD",
"{u} (Gene) is downregulated by {v} ... | Flurbiprofen (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Famotidine (Compound)
Flurbiprofen (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Famotidine (Compound)
Flurbiprofen may lead to a major life threatening interaction when taken with Ketorolac and Ketoro... |
DB00812 | DB12010 | 998 | 214 | [
"DDInter1451",
"DDInter785"
] | Phenylbutazone | Fostamatinib | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
998,
24,
214
]
],
[
[
998,
24,
976
],
[
976,
24,
214
]
],
[
[
998,
63,
723
],
[
723,
24,
214
]
],
[
[
998,
40,
307
],
[
307,
24,... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitan... |
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