drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01045 | DB09049 | 463 | 1,135 | [
"DDInter1590",
"DDInter1261"
] | Rifampicin | Naloxegol | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Major | 2 | [
[
[
463,
25,
1135
]
],
[
[
463,
25,
1406
],
[
1406,
62,
1135
]
],
[
[
463,
64,
1424
],
[
1424,
23,
1135
]
],
[
[
463,
24,
1069
],
[
1069,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
],
[
"Neratinib",
"{u} may ... | Rifampicin may lead to a major life threatening interaction when taken with Neratinib and Neratinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Rifampicin may lead to a major life threatening interaction when taken with Quinine and Quinine may cause a minor interaction that c... |
DB08870 | DB08896 | 850 | 292 | [
"DDInter228",
"DDInter1576"
] | Brentuximab vedotin | Regorafenib | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
850,
24,
292
]
],
[
[
850,
63,
79
],
[
79,
1,
292
]
],
[
[
850,
63,
549
],
[
549,
23,
292
]
],
[
[
850,
24,
327
],
[
327,
63,
... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafeni... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a minor in... |
DB00710 | DB01575 | 1,199 | 1,054 | [
"DDInter897",
"DDInter1005"
] | Ibandronate | Kaolin | Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatm... | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Moderate | 1 | [
[
[
1199,
24,
1054
]
],
[
[
1199,
1,
1008
],
[
1008,
24,
1054
]
],
[
[
1199,
40,
1485
],
[
1485,
24,
1054
]
],
[
[
1199,
1,
1008
],
[
1008... | [
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kaolin"
]
],
[
[
"Ibandronate",
"{u} (Compound) resembles {v} (Compound)",
"Risedronic acid"
],
[
"Risedronic acid",
"{u} may cause a... | Ibandronate (Compound) resembles Risedronic acid (Compound) and Risedronic acid may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Ibandronate (Compound) resembles Alendronic acid (Compound) and Alendronic acid may cause a moderate interaction that could exacerbate diseases when take... |
DB00553 | DB06290 | 92 | 1,449 | [
"DDInter1177",
"DDInter1673"
] | Methoxsalen | Simeprevir | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. | Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, an... | Moderate | 1 | [
[
[
92,
24,
1449
]
],
[
[
92,
6,
7950
],
[
7950,
45,
1449
]
],
[
[
92,
21,
28762
],
[
28762,
60,
1449
]
],
[
[
92,
24,
866
],
[
866,
... | [
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simeprevir"
]
],
[
[
"Methoxsalen",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)... | Methoxsalen (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Simeprevir (Compound)
Methoxsalen (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Simeprevir (Compound)
Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib and Co... |
DB01045 | DB09065 | 463 | 760 | [
"DDInter1590",
"DDInter424"
] | Rifampicin | Cobicistat | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
463,
25,
760
]
],
[
[
463,
62,
1101
],
[
1101,
23,
760
]
],
[
[
463,
25,
1374
],
[
1374,
23,
760
]
],
[
[
463,
63,
1041
],
[
1041,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Rifampicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",... | Rifampicin may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Rifampicin may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a ... |
DB00734 | DB06603 | 1,664 | 39 | [
"DDInter1605",
"DDInter1387"
] | Risperidone | Panobinostat | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1664,
25,
39
]
],
[
[
1664,
23,
112
],
[
112,
23,
39
]
],
[
[
1664,
24,
272
],
[
272,
24,
39
]
],
[
[
1664,
63,
506
],
[
506,
24... | [
[
[
"Risperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Risperidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Risperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramin... |
DB06603 | DB11796 | 39 | 1,612 | [
"DDInter1387",
"DDInter786"
] | Panobinostat | Fostemsavir | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Major | 2 | [
[
[
39,
25,
1612
]
],
[
[
39,
63,
1051
],
[
1051,
23,
1612
]
],
[
[
39,
24,
98
],
[
98,
23,
1612
]
],
[
[
39,
24,
1017
],
[
1017,
62... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
]
],
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
[
... | Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Soma... |
DB09073 | DB15822 | 951 | 69 | [
"DDInter1379",
"DDInter1504"
] | Palbociclib | Pralsetinib | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small... | Moderate | 1 | [
[
[
951,
24,
69
]
],
[
[
951,
24,
283
],
[
283,
24,
69
]
],
[
[
951,
63,
1446
],
[
1446,
24,
69
]
],
[
[
951,
64,
609
],
[
609,
25,
... | [
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pralsetinib"
]
],
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[... | Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Pralsetinib
Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide and Lan... |
DB08865 | DB12001 | 1,593 | 564 | [
"DDInter448",
"DDInter7"
] | Crizotinib | Abemaciclib | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
1593,
24,
564
]
],
[
[
1593,
63,
536
],
[
536,
24,
564
]
],
[
[
1593,
25,
868
],
[
868,
24,
564
]
],
[
[
1593,
64,
392
],
[
392,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
],
[... | Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Crizotinib may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may... |
DB00321 | DB01069 | 21 | 401 | [
"DDInter78",
"DDInter1533"
] | Amitriptyline | Promethazine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
21,
35,
401
]
],
[
[
21,
1,
11275
],
[
11275,
40,
401
]
],
[
[
21,
35,
1264
],
[
1264,
63,
401
]
],
[
[
21,
24,
649
],
[
649,
63... | [
[
[
"Amitriptyline",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Amitriptyline",
"{u} (Compound) resembles {v} (Compound)",
"Chlorprothixene"
],... | Amitriptyline (Compound) resembles Promethazine (Compound) and
Amitriptyline (Compound) resembles Chlorprothixene (Compound) and Chlorprothixene (Compound) resembles Promethazine (Compound)
Amitriptyline (Compound) resembles Doxepin (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate dis... |
DB00683 | DB06273 | 1,382 | 980 | [
"DDInter1212",
"DDInter1824"
] | Midazolam | Tocilizumab | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
1382,
24,
980
]
],
[
[
1382,
1,
902
],
[
902,
24,
980
]
],
[
[
1382,
62,
1031
],
[
1031,
24,
980
]
],
[
[
1382,
24,
629
],
[
629,
... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Midazolam",
"{u} (Compound) resembles {v} (Compound)",
"Clobazam"
],
[
"Clobazam",
"{u} may cause a moderate int... | Midazolam (Compound) resembles Clobazam (Compound) and Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Midazolam may cause a minor interaction that can limit clinical effects when taken with Theophylline and Theophylline may cause a moderate interaction that could ex... |
DB09048 | DB11703 | 555 | 405 | [
"DDInter1284",
"DDInter9"
] | Netupitant | Acalabrutinib | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
555,
25,
405
]
],
[
[
555,
63,
1324
],
[
1324,
24,
405
]
],
[
[
555,
62,
1101
],
[
1101,
24,
405
]
],
[
[
555,
24,
951
],
[
951,
... | [
[
[
"Netupitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Netupitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[
"Trogl... | Netupitant may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Netupitant may cause a minor interaction that can limit clinical effects when taken with Bexarotene and B... |
DB01157 | DB14443 | 304 | 987 | [
"DDInter1875",
"DDInter1931"
] | Trimetrexate | Vibrio cholerae CVD 103-HgR strain live antigen | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
304,
24,
987
]
],
[
[
304,
63,
305
],
[
305,
24,
987
]
],
[
[
304,
24,
259
],
[
259,
24,
987
]
],
[
[
304,
64,
581
],
[
581,
24,... | [
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with... | Trimetrexate may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Trimetrexate may cause a moderate i... |
DB00773 | DB01611 | 896 | 1,487 | [
"DDInter702",
"DDInter893"
] | Etoposide | Hydroxychloroquine | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
896,
24,
1487
]
],
[
[
896,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
896,
63,
663
],
[
663,
23,
1487
]
],
[
[
896,
63,
723
],
[
723,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Etoposide",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is ... | Etoposide (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with H... |
DB00443 | DB14006 | 251 | 972 | [
"DDInter195",
"DDInter370"
] | Betamethasone | Choline salicylate | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
251,
24,
972
]
],
[
[
251,
23,
771
],
[
771,
62,
972
]
],
[
[
251,
1,
1573
],
[
1573,
24,
972
]
],
[
[
251,
63,
176
],
[
176,
24... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Betamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
... | Betamethasone may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Choline salicylate
Betamethasone (Compound) resembles Prednisone (Compound) and Prednisone may cause a moderate intera... |
DB00580 | DB09472 | 311 | 1,383 | [
"DDInter1910",
"DDInter1693"
] | Valdecoxib | Sodium sulfate | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
311,
24,
1383
]
],
[
[
311,
24,
609
],
[
609,
24,
1383
]
],
[
[
311,
63,
600
],
[
600,
24,
1383
]
],
[
[
311,
24,
877
],
[
877,
... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Fluconazo... |
DB01166 | DB11718 | 477 | 927 | [
"DDInter379",
"DDInter640"
] | Cilostazol | Encorafenib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
477,
24,
927
]
],
[
[
477,
62,
112
],
[
112,
23,
927
]
],
[
[
477,
24,
720
],
[
720,
24,
927
]
],
[
[
477,
63,
216
],
[
216,
24,... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Cilostazol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Cilostazol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil and Mi... |
DB08815 | DB09268 | 154 | 1,662 | [
"DDInter1104",
"DDInter1464"
] | Lurasidone | Picosulfuric acid | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
154,
24,
1662
]
],
[
[
154,
24,
484
],
[
484,
63,
1662
]
],
[
[
154,
63,
597
],
[
597,
24,
1662
]
],
[
[
154,
25,
913
],
[
913,
... | [
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
],
... | Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Chlorampheni... |
DB00461 | DB00585 | 598 | 1,127 | [
"DDInter1254",
"DDInter1309"
] | Nabumetone | Nizatidine | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. | Minor | 0 | [
[
[
598,
23,
1127
]
],
[
[
598,
23,
1194
],
[
1194,
40,
1127
]
],
[
[
598,
6,
7720
],
[
7720,
46,
1127
]
],
[
[
598,
18,
2060
],
[
2060,
... | [
[
[
"Nabumetone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nizatidine"
]
],
[
[
"Nabumetone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
],
[
... | Nabumetone may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranitidine (Compound) resembles Nizatidine (Compound)
Nabumetone (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Nizatidine (Compound)
Nabumetone (Compound) downregulates PIK3CA (Gene) and PIK3CA (Ge... |
DB06203 | DB09381 | 1,002 | 192 | [
"DDInter51",
"DDInter678"
] | Alogliptin | Esterified estrogens | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
1002,
24,
192
]
],
[
[
1002,
24,
1019
],
[
1019,
63,
192
]
],
[
[
1002,
63,
1685
],
[
1685,
24,
192
]
],
[
[
1002,
24,
1040
],
[
1040,... | [
[
[
"Alogliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Alogliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
... | Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens
Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Insulin h... |
DB00333 | DB00526 | 576 | 1,555 | [
"DDInter1166",
"DDInter1355"
] | Methadone | Oxaliplatin | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Major | 2 | [
[
[
576,
25,
1555
]
],
[
[
576,
6,
7950
],
[
7950,
45,
1555
]
],
[
[
576,
1,
97
],
[
97,
63,
1555
]
],
[
[
576,
25,
79
],
[
79,
24,
... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Methadone",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"Oxalipla... | Methadone (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Oxaliplatin (Compound)
Methadone (Compound) resembles Oxaprozin (Compound) and Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Methadone may lead to a major life threatening interaction when take... |
DB00231 | DB01612 | 1,174 | 1,637 | [
"DDInter1761",
"DDInter92"
] | Temazepam | Amyl Nitrite | Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chem... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
1174,
24,
1637
]
],
[
[
1174,
1,
1216
],
[
1216,
24,
1637
]
],
[
[
1174,
25,
475
],
[
475,
24,
1637
]
],
[
[
1174,
24,
401
],
[
401,
... | [
[
[
"Temazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Temazepam",
"{u} (Compound) resembles {v} (Compound)",
"Flurazepam"
],
[
"Flurazepam",
"{u} may cause a moderat... | Temazepam (Compound) resembles Flurazepam (Compound) and Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Temazepam may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate disease... |
DB00033 | DB00099 | 342 | 440 | [
"DDInter949",
"DDInter735"
] | Interferon gamma-1b | Filgrastim | Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence ... | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Moderate | 1 | [
[
[
342,
24,
440
]
],
[
[
342,
25,
1101
],
[
1101,
63,
440
]
],
[
[
342,
24,
869
],
[
869,
63,
440
]
],
[
[
342,
63,
305
],
[
305,
2... | [
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Filgrastim"
]
],
[
[
"Interferon gamma-1b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[... | Interferon gamma-1b may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Filgrastim
Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topo... |
DB00497 | DB09046 | 828 | 1,094 | [
"DDInter1366",
"DDInter1201"
] | Oxycodone | Metreleptin | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Moderate | 1 | [
[
[
828,
24,
1094
]
],
[
[
828,
24,
578
],
[
578,
24,
1094
]
],
[
[
828,
24,
927
],
[
927,
63,
1094
]
],
[
[
828,
25,
384
],
[
384,
... | [
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
]
],
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
... | Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin
Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encora... |
DB01004 | DB04845 | 563 | 309 | [
"DDInter806",
"DDInter1001"
] | Ganciclovir | Ixabepilone | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
563,
24,
309
]
],
[
[
563,
21,
28736
],
[
28736,
60,
309
]
],
[
[
563,
24,
60
],
[
60,
23,
309
]
],
[
[
563,
63,
1419
],
[
1419,
... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Ganciclovir",
"{u} (Compound) causes {v} (Side Effect)",
"Dehydration"
],
[
"Dehydration",
"{u} (Side Effect) ... | Ganciclovir (Compound) causes Dehydration (Side Effect) and Dehydration (Side Effect) is caused by Ixabepilone (Compound)
Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Capecitabine and Capecitabine may cause a minor interaction that can limit clinical effects when taken wit... |
DB00418 | DB00620 | 536 | 175 | [
"DDInter1650",
"DDInter1855"
] | Secobarbital | Triamcinolone | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Moderate | 1 | [
[
[
536,
24,
175
]
],
[
[
536,
24,
1573
],
[
1573,
1,
175
]
],
[
[
536,
21,
28762
],
[
28762,
60,
175
]
],
[
[
536,
24,
1419
],
[
1419,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
]
],
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
... | Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Secobarbital (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Triamcinolone (Compound)
Secobarbital may cause a moderate in... |
DB00855 | DB01124 | 213 | 1,411 | [
"DDInter72",
"DDInter1828"
] | Aminolevulinic acid | Tolbutamide | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Major | 2 | [
[
[
213,
25,
1411
]
],
[
[
213,
25,
959
],
[
959,
40,
1411
]
],
[
[
213,
64,
245
],
[
245,
40,
1411
]
],
[
[
213,
6,
4610
],
[
4610,
... | [
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tolbutamide"
]
],
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glipizide"
],
[
"Glipizi... | Aminolevulinic acid may lead to a major life threatening interaction when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Aminolevulinic acid may lead to a major life threatening interaction when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound)
Aminolevul... |
DB00425 | DB01069 | 558 | 401 | [
"DDInter1970",
"DDInter1533"
] | Zolpidem | Promethazine | Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of s... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
558,
24,
401
]
],
[
[
558,
24,
1264
],
[
1264,
63,
401
]
],
[
[
558,
6,
12523
],
[
12523,
45,
401
]
],
[
[
558,
21,
28709
],
[
28709,
... | [
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
"... | Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Zolpidem (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Promethazine (Compound)
Zolpidem (Compound) caus... |
DB00651 | DB04861 | 746 | 1,592 | [
"DDInter613",
"DDInter1271"
] | Dyphylline | Nebivolol | Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Major | 2 | [
[
[
746,
25,
1592
]
],
[
[
746,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
746,
24,
144
],
[
144,
63,
1592
]
],
[
[
746,
23,
22
],
[
22,
... | [
[
[
"Dyphylline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nebivolol"
]
],
[
[
"Dyphylline",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by {v} (Compoun... | Dyphylline (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Dyphylline may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Nebivolol
... |
DB00006 | DB14276 | 942 | 1,631 | [
"DDInter217",
"DDInter1892"
] | Bivalirudin | Turmeric | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
942,
23,
1631
]
],
[
[
942,
25,
20
],
[
20,
23,
1631
]
],
[
[
942,
24,
1018
],
[
1018,
23,
1631
]
],
[
[
942,
64,
1578
],
[
1578,
... | [
[
[
"Bivalirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
]
],
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tenecteplase"
],
[
"Tenectepla... | Bivalirudin may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplase may cause a minor interaction that can limit clinical effects when taken with Turmeric
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticlopidine may ca... |
DB00574 | DB01142 | 121 | 1,264 | [
"DDInter717",
"DDInter593"
] | Fenfluramine | Doxepin | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
121,
24,
1264
]
],
[
[
121,
25,
1405
],
[
1405,
25,
1264
]
],
[
[
121,
63,
847
],
[
847,
23,
1264
]
],
[
[
121,
25,
413
],
[
413,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cyclobenzaprine"
],
[
"Cycl... | Fenfluramine may lead to a major life threatening interaction when taken with Cyclobenzaprine and Cyclobenzaprine may lead to a major life threatening interaction when taken with Doxepin
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine may cause a ... |
DB01041 | DB04844 | 770 | 843 | [
"DDInter1789",
"DDInter1778"
] | Thalidomide | Tetrabenazine | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Moderate | 1 | [
[
[
770,
24,
843
]
],
[
[
770,
63,
479
],
[
479,
40,
843
]
],
[
[
770,
18,
2357
],
[
2357,
57,
843
]
],
[
[
770,
21,
28698
],
[
28698,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil (Compound) resembles Tetrabenazine (Compound)
Thalidomide (Compound) downregulates GRB7 (Gene) and GRB7 (Gene) is downregulated by Tetrabenazine (Compound)
Thalidomide (Compound) causes Insomnia (Side Eff... |
DB00206 | DB01075 | 1,245 | 1,376 | [
"DDInter1582",
"DDInter569"
] | Reserpine | Diphenhydramine | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1245,
24,
1376
]
],
[
[
1245,
24,
401
],
[
401,
24,
1376
]
],
[
[
1245,
6,
8803
],
[
8803,
45,
1376
]
],
[
[
1245,
21,
28921
],
[
2892... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Reserpine (Compound) binds SLC22A2 (Gene) and SLC22A2 (Gene) is bound by Diphenhydramine (Compound)
Rese... |
DB00040 | DB01136 | 27 | 772 | [
"DDInter827",
"DDInter305"
] | Glucagon | Carvedilol | Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.[L7634,L7637,L7640,L7643,L8519] Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Minor | 0 | [
[
[
27,
23,
772
]
],
[
[
27,
23,
699
],
[
699,
5,
11590
],
[
11590,
44,
772
]
],
[
[
27,
23,
722
],
[
722,
24,
1276
],
[
1276,
63,
... | [
[
[
"Glucagon",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Carvedilol"
]
],
[
[
"Glucagon",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nadolol"
],
[
"Nadolo... | Glucagon may cause a minor interaction that can limit clinical effects when taken with Nadolol and Nadolol (Compound) treats hypertension (Disease) and hypertension (Disease) is treated by Carvedilol (Compound)
Glucagon may cause a minor interaction that can limit clinical effects when taken with Levobetaxolol and Levo... |
DB00582 | DB01069 | 1,622 | 401 | [
"DDInter1946",
"DDInter1533"
] | Voriconazole | Promethazine | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1622,
24,
401
]
],
[
[
1622,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1622,
6,
7603
],
[
7603,
45,
401
]
],
[
[
1622,
21,
28709
],
[
28709... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Voriconazole (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Promethazine (Compound)
Voriconazole (Co... |
DB00619 | DB01072 | 1,419 | 915 | [
"DDInter909",
"DDInter129"
] | Imatinib | Atazanavir | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Moderate | 1 | [
[
[
1419,
24,
915
]
],
[
[
1419,
24,
1327
],
[
1327,
1,
915
]
],
[
[
1419,
6,
4973
],
[
4973,
45,
915
]
],
[
[
1419,
21,
29051
],
[
29051,... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atazanavir"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Atazanavir (Compound)
Imatinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Atazanavir (Compound)
Imatinib (Compound) causes Fluid retention (Side Effect) and Fluid reten... |
DB00222 | DB01136 | 245 | 772 | [
"DDInter825",
"DDInter305"
] | Glimepiride | Carvedilol | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
245,
24,
772
]
],
[
[
245,
6,
6017
],
[
6017,
45,
772
]
],
[
[
245,
21,
28729
],
[
28729,
60,
772
]
],
[
[
245,
24,
542
],
[
542,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Glimepiride",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)... | Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Carvedilol (Compound)
Glimepiride (Compound) causes Pain in extremity (Side Effect) and Pain in extremity (Side Effect) is caused by Carvedilol (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00382 | DB12245 | 62 | 823 | [
"DDInter1734",
"DDInter1863"
] | Tacrine | Triclabendazole | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
62,
24,
823
]
],
[
[
62,
24,
112
],
[
112,
23,
823
]
],
[
[
62,
63,
1010
],
[
1010,
24,
823
]
],
[
[
62,
24,
77
],
[
77,
24,
... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mef... |
DB01219 | DB06691 | 716 | 849 | [
"DDInter473",
"DDInter1155"
] | Dantrolene | Mepyramine | Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
716,
24,
849
]
],
[
[
716,
63,
1594
],
[
1594,
24,
849
]
],
[
[
716,
24,
407
],
[
407,
63,
849
]
],
[
[
716,
24,
649
],
[
649,
2... | [
[
[
"Dantrolene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Dantrolene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Dantrolene may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Dantrolene may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may c... |
DB11915 | DB12245 | 1,293 | 823 | [
"DDInter1909",
"DDInter1863"
] | Valbenazine | Triclabendazole | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1293,
24,
823
]
],
[
[
1293,
62,
112
],
[
112,
23,
823
]
],
[
[
1293,
63,
1010
],
[
1010,
24,
823
]
],
[
[
1293,
24,
971
],
[
971,
... | [
[
[
"Valbenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Valbenazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Valbenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Valbenazine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine a... |
DB09237 | DB11130 | 1,586 | 407 | [
"DDInter1045",
"DDInter1344"
] | Levamlodipine | Opium | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1586,
24,
407
]
],
[
[
1586,
63,
104
],
[
104,
24,
407
]
],
[
[
1586,
62,
578
],
[
578,
24,
407
]
],
[
[
1586,
63,
1053
],
[
1053,
... | [
[
[
"Levamlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Levamlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[... | Levamlodipine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Levamlodipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor and Tic... |
DB00262 | DB00365 | 552 | 839 | [
"DDInter302",
"DDInter842"
] | Carmustine | Grepafloxacin | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Minor | 0 | [
[
[
552,
23,
839
]
],
[
[
552,
35,
37
],
[
37,
62,
839
]
],
[
[
552,
24,
1224
],
[
1224,
62,
839
]
],
[
[
552,
24,
329
],
[
329,
23,... | [
[
[
"Carmustine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Grepafloxacin"
]
],
[
[
"Carmustine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken ... | Carmustine (Compound) resembles Lomustine (Compound) and Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Carmustine may cause a moderate interaction that could e... |
DB00563 | DB06777 | 663 | 780 | [
"DDInter1174",
"DDInter348"
] | Methotrexate | Chenodeoxycholic acid | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decre... | Moderate | 1 | [
[
[
663,
24,
780
]
],
[
[
663,
21,
28957
],
[
28957,
60,
780
]
],
[
[
663,
24,
384
],
[
384,
63,
780
]
],
[
[
663,
24,
267
],
[
267,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chenodeoxycholic acid"
]
],
[
[
"Methotrexate",
"{u} (Compound) causes {v} (Side Effect)",
"Arthralgia"
],
[
"Arthralgia",
"{u} (Sid... | Methotrexate (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Chenodeoxycholic acid (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when t... |
DB00749 | DB01240 | 59 | 885 | [
"DDInter699",
"DDInter657"
] | Etodolac | Epoprostenol | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
59,
24,
885
]
],
[
[
59,
63,
1061
],
[
1061,
1,
885
]
],
[
[
59,
6,
6017
],
[
6017,
45,
885
]
],
[
[
59,
21,
28936
],
[
28936,
6... | [
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Etodolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
... | Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Etodolac (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Epoprostenol (Compound)
Etodolac (Compound) causes Hyperhidrosis (Side Effect) and Hyp... |
DB01105 | DB08816 | 222 | 578 | [
"DDInter1665",
"DDInter1802"
] | Sibutramine | Ticagrelor | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
222,
24,
578
]
],
[
[
222,
6,
8374
],
[
8374,
45,
578
]
],
[
[
222,
21,
28645
],
[
28645,
60,
578
]
],
[
[
222,
63,
1578
],
[
1578,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Sibutramine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Sibutramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ticagrelor (Compound)
Sibutramine (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Ticagrelor (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Lepirudin and Lepirudin ... |
DB00405 | DB01192 | 128 | 560 | [
"DDInter517",
"DDInter1372"
] | Dexbrompheniramine | Oxymorphone | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
128,
24,
560
]
],
[
[
128,
24,
828
],
[
828,
1,
560
]
],
[
[
128,
63,
421
],
[
421,
1,
560
]
],
[
[
128,
24,
1123
],
[
1123,
24,... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles O... |
DB00554 | DB11793 | 1,027 | 738 | [
"DDInter1478",
"DDInter1297"
] | Piroxicam | Niraparib | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
1027,
24,
738
]
],
[
[
1027,
25,
1213
],
[
1213,
24,
738
]
],
[
[
1027,
24,
1033
],
[
1033,
63,
738
]
],
[
[
1027,
63,
1578
],
[
1578,... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Piroxicam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib",
... | Piroxicam may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moder... |
DB08864 | DB09122 | 786 | 1,613 | [
"DDInter1595",
"DDInter1409"
] | Rilpivirine | Peginterferon beta-1a | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
786,
24,
1613
]
],
[
[
786,
63,
600
],
[
600,
24,
1613
]
],
[
[
786,
24,
1383
],
[
1383,
63,
1613
]
],
[
[
786,
25,
351
],
[
351,
... | [
[
[
"Rilpivirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Rilpivirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
... | Rilpivirine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Rilpivirine may cause a moderate interaction that could exacerbate diseases when taken with Sodium... |
DB00697 | DB00804 | 876 | 1,507 | [
"DDInter1821",
"DDInter543"
] | Tizanidine | Dicyclomine | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Moderate | 1 | [
[
[
876,
24,
1507
]
],
[
[
876,
21,
29231
],
[
29231,
60,
1507
]
],
[
[
876,
63,
1594
],
[
1594,
24,
1507
]
],
[
[
876,
24,
832
],
[
832,
... | [
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
]
],
[
[
"Tizanidine",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac disorder"
],
[
"Cardiac disorder",
"{u} (Side ... | Tizanidine (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Dicyclomine (Compound)
Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when tak... |
DB00562 | DB00572 | 1,014 | 85 | [
"DDInter188",
"DDInter136"
] | Benzthiazide | Atropine | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Minor | 0 | [
[
[
1014,
23,
85
]
],
[
[
1014,
62,
19
],
[
19,
24,
85
]
],
[
[
1014,
25,
1166
],
[
1166,
40,
85
]
],
[
[
1014,
40,
178
],
[
178,
62... | [
[
[
"Benzthiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Atropine"
]
],
[
[
"Benzthiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyoscyamine"
],
[
... | Benzthiazide may cause a minor interaction that can limit clinical effects when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Benzthiazide may lead to a major life threatening interaction when taken with Dolasetron and Dolasetron (Compoun... |
DB00005 | DB00108 | 1,057 | 1,066 | [
"DDInter687",
"DDInter1268"
] | Etanercept | Natalizumab | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Major | 2 | [
[
[
1057,
25,
1066
]
],
[
[
1057,
23,
1114
],
[
1114,
62,
1066
]
],
[
[
1057,
24,
949
],
[
949,
63,
1066
]
],
[
[
1057,
25,
375
],
[
375,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Natalizumab"
]
],
[
[
"Etanercept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
"Zinc sulf... | Etanercept may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Natalizumab
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani t... |
DB00703 | DB09135 | 997 | 1,211 | [
"DDInter1167",
"DDInter967"
] | Methazolamide | Ioxilan | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Moderate | 1 | [
[
[
997,
24,
1211
]
],
[
[
997,
40,
471
],
[
471,
24,
1211
]
],
[
[
997,
63,
1648
],
[
1648,
24,
1211
]
],
[
[
997,
63,
1287
],
[
1287,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioxilan"
]
],
[
[
"Methazolamide",
"{u} (Compound) resembles {v} (Compound)",
"Acetazolamide"
],
[
"Acetazolamide",
"{u} may cause ... | Methazolamide (Compound) resembles Acetazolamide (Compound) and Acetazolamide may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction... |
DB00515 | DB14409 | 589 | 1,129 | [
"DDInter387",
"DDInter867"
] | Cisplatin | Human adenovirus e serotype 4 strain cl-68578 antigen | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
589,
24,
1129
]
],
[
[
589,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
589,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
589,
63,
134
],
[
134,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Cisplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"E... | Cisplatin may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01234 | DB06186 | 1,220 | 1,439 | [
"DDInter513",
"DDInter969"
] | Dexamethasone | Ipilimumab | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Moderate | 1 | [
[
[
1220,
24,
1439
]
],
[
[
1220,
1,
617
],
[
617,
24,
1439
]
],
[
[
1220,
24,
1412
],
[
1412,
63,
1439
]
],
[
[
1220,
63,
1560
],
[
1560,... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
]
],
[
[
"Dexamethasone",
"{u} (Compound) resembles {v} (Compound)",
"Budesonide"
],
[
"Budesonide",
"{u} may cause a m... | Dexamethasone (Compound) resembles Budesonide (Compound) and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol and Calaspargase pegol may cause a moderate ... |
DB00652 | DB09472 | 234 | 1,383 | [
"DDInter1421",
"DDInter1693"
] | Pentazocine | Sodium sulfate | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
234,
24,
1383
]
],
[
[
234,
24,
1311
],
[
1311,
24,
1383
]
],
[
[
234,
25,
1133
],
[
1133,
24,
1383
]
],
[
[
234,
64,
1494
],
[
1494,
... | [
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]... | Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Pentazocine may lead to a major life threatening interaction when taken with Granisetron and Granis... |
DB00424 | DB01176 | 19 | 537 | [
"DDInter896",
"DDInter453"
] | Hyoscyamine | Cyclizine | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
19,
24,
537
]
],
[
[
19,
24,
1511
],
[
1511,
63,
537
]
],
[
[
19,
24,
104
],
[
104,
1,
537
]
],
[
[
19,
24,
13
],
[
13,
24,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and M... |
DB00288 | DB09038 | 1,103 | 1,450 | [
"DDInter63",
"DDInter636"
] | Amcinonide | Empagliflozin | Amcinonide is a corticosteroid. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Minor | 0 | [
[
[
1103,
23,
1450
]
],
[
[
1103,
62,
1179
],
[
1179,
24,
1450
]
],
[
[
1103,
40,
870
],
[
870,
24,
1450
]
],
[
[
1103,
23,
1296
],
[
1296... | [
[
[
"Amcinonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Empagliflozin"
]
],
[
[
"Amcinonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Insulin lispro"
],
[... | Amcinonide may cause a minor interaction that can limit clinical effects when taken with Insulin lispro and Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Amcinonide (Compound) resembles Fludrocortisone (Compound) and Fludrocortisone may cause a moderate int... |
DB06228 | DB11718 | 792 | 927 | [
"DDInter1609",
"DDInter640"
] | Rivaroxaban | Encorafenib | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
792,
24,
927
]
],
[
[
792,
63,
536
],
[
536,
24,
927
]
],
[
[
792,
64,
998
],
[
998,
24,
927
]
],
[
[
792,
24,
1491
],
[
1491,
2... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
],
... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Rivaroxaban may lead to a major life threatening interaction when taken with Phenylbutazone and Phenylbuta... |
DB00862 | DB00927 | 1,005 | 1,559 | [
"DDInter1918",
"DDInter712"
] | Vardenafil | Famotidine | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
1005,
24,
1559
]
],
[
[
1005,
21,
28787
],
[
28787,
60,
1559
]
],
[
[
1005,
24,
286
],
[
286,
62,
1559
]
],
[
[
1005,
24,
112
],
[
112... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Vardenafil",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is ca... | Vardenafil (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Famotidine (Compound)
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effects when ... |
DB00450 | DB05294 | 78 | 1,069 | [
"DDInter603",
"DDInter1917"
] | Droperidol | Vandetanib | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
78,
25,
1069
]
],
[
[
78,
21,
28921
],
[
28921,
60,
1069
]
],
[
[
78,
23,
112
],
[
112,
23,
1069
]
],
[
[
78,
24,
659
],
[
659,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Droperidol",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is caused by {v} (Comp... | Droperidol (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Vandetanib (Compound)
Droperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Vande... |
DB00439 | DB11158 | 289 | 1,452 | [
"DDInter341",
"DDInter1401"
] | Cerivastatin | Pectin | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Pectin is a heteropolysaccharide commercially derived from the cell wall of higher plants. It is composed of partially methylated polygalacturonic acid units linked in the positions 1-4. The carboxylic group of the constituents of pectin can exist in the form of esters, free acids, ammonium, potassium or sodium salts o... | Moderate | 1 | [
[
[
289,
24,
1452
]
],
[
[
289,
24,
467
],
[
467,
24,
1452
]
],
[
[
289,
24,
322
],
[
322,
63,
681
],
[
681,
24,
1452
]
],
[
[
289,
... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pectin"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
],
[
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Pectin
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epir... |
DB00307 | DB00990 | 1,101 | 1,547 | [
"DDInter202",
"DDInter705"
] | Bexarotene | Exemestane | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Moderate | 1 | [
[
[
1101,
24,
1547
]
],
[
[
1101,
24,
891
],
[
891,
40,
1547
]
],
[
[
1101,
63,
380
],
[
380,
24,
1547
]
],
[
[
1101,
24,
559
],
[
559,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exemestane"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone (Compound) resembles Exemestane (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens and Conjugated estrogens may cause a moderat... |
DB00443 | DB10989 | 251 | 496 | [
"DDInter195",
"DDInter858"
] | Betamethasone | Hepatitis A Vaccine | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
251,
24,
496
]
],
[
[
251,
24,
4
],
[
4,
24,
496
]
],
[
[
251,
1,
175
],
[
175,
24,
496
]
],
[
[
251,
63,
1101
],
[
1101,
24,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine ... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Betamethasone (Compound) resembles Triamcinolone (Compound) and Triamc... |
DB00400 | DB00705 | 353 | 441 | [
"DDInter843",
"DDInter496"
] | Griseofulvin | Delavirdine | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Moderate | 1 | [
[
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[
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[
[
353,
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303
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[
303,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delavirdine"
]
],
[
[
"Griseofulvin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Griseofulvin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Delavirdine (Compound)
Griseofulvin (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Delavirdine (Compound)
Griseofulvin may lead to a major life threatening interaction when taken with Medroxyprogesterone acetat... |
DB00757 | DB00816 | 1,166 | 1,674 | [
"DDInter581",
"DDInter1346"
] | Dolasetron | Orciprenaline | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Major | 2 | [
[
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1166,
25,
1674
]
],
[
[
1166,
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28921
],
[
28921,
60,
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[
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1166,
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[
1164,
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[
[
1166,
25,
819
],
[
8... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Orciprenaline"
]
],
[
[
"Dolasetron",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is caused by {v} (C... | Dolasetron (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orciprenaline (Compound)
Dolasetron may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline
D... |
DB01166 | DB11113 | 477 | 657 | [
"DDInter379",
"DDInter307"
] | Cilostazol | Castor oil | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
477,
24,
657
]
],
[
[
477,
24,
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],
[
1079,
24,
657
]
],
[
[
477,
24,
927
],
[
927,
63,
657
]
],
[
[
477,
25,
540
],
[
540,
2... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
],
[
... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Telavancin and Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encor... |
DB09065 | DB11652 | 760 | 1,155 | [
"DDInter424",
"DDInter1891"
] | Cobicistat | Tucatinib | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Moderate | 1 | [
[
[
760,
24,
1155
]
],
[
[
760,
62,
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],
[
1101,
23,
1155
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],
[
[
760,
63,
1424
],
[
1424,
24,
1155
]
],
[
[
760,
24,
659
],
[
659,
... | [
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tucatinib"
]
],
[
[
"Cobicistat",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
... | Cobicistat may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may ca... |
DB00668 | DB01159 | 874 | 419 | [
"DDInter652",
"DDInter854"
] | Epinephrine | Halothane | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Major | 2 | [
[
[
874,
25,
419
]
],
[
[
874,
25,
1280
],
[
1280,
1,
419
]
],
[
[
874,
6,
8374
],
[
8374,
45,
419
]
],
[
[
874,
24,
1148
],
[
1148,
... | [
[
[
"Epinephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halothane"
]
],
[
[
"Epinephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isoflurane"
],
[
"Isoflurane",
"{u} ... | Epinephrine may lead to a major life threatening interaction when taken with Isoflurane and Isoflurane (Compound) resembles Halothane (Compound)
Epinephrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Halothane (Compound)
Epinephrine may cause a moderate interaction that could exacerbate diseases when ... |
DB01168 | DB10429 | 1,053 | 200 | [
"DDInter1526",
"DDInter282"
] | Procarbazine | Candida albicans | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
1053,
24,
200
]
],
[
[
1053,
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],
[
1683,
24,
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]
],
[
[
1053,
25,
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[
976,
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]
],
[
[
1053,
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869
],
[
869,
... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Procarbazine may lead to a major life threatening interaction when taken with Tofacitinib and Tofaciti... |
DB00916 | DB06414 | 112 | 655 | [
"DDInter1202",
"DDInter703"
] | Metronidazole | Etravirine | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
112,
24,
655
]
],
[
[
112,
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],
[
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655
]
],
[
[
112,
6,
6017
],
[
6017,
45,
655
]
],
[
[
112,
21,
28883
],
[
28883,
... | [
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rilpivirine"
],
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rilpivirine and Rilpivirine (Compound) resembles Etravirine (Compound)
Metronidazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Etravirine (Compound)
Metronidazole (Compound) causes Skin disorder (Side Effect) ... |
DB01227 | DB01611 | 1,301 | 1,487 | [
"DDInter1043",
"DDInter893"
] | Levacetylmethadol | Hydroxychloroquine | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
1301,
25,
1487
]
],
[
[
1301,
64,
1520
],
[
1520,
25,
1487
]
],
[
[
1301,
64,
723
],
[
723,
24,
1487
]
],
[
[
1301,
24,
286
],
[
286,
... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
],
[
"Pri... | Levacetylmethadol may lead to a major life threatening interaction when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Levacetylmethadol may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant may cause a modera... |
DB00087 | DB06674 | 599 | 908 | [
"DDInter41",
"DDInter837"
] | Alemtuzumab | Golimumab | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
599,
24,
908
]
],
[
[
599,
63,
268
],
[
268,
24,
908
]
],
[
[
599,
24,
208
],
[
208,
24,
908
]
],
[
[
599,
24,
200
],
[
200,
63,... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00619 | DB00802 | 1,419 | 1,322 | [
"DDInter909",
"DDInter43"
] | Imatinib | Alfentanil | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Major | 2 | [
[
[
1419,
25,
1322
]
],
[
[
1419,
25,
704
],
[
704,
1,
1322
]
],
[
[
1419,
24,
1454
],
[
1454,
1,
1322
]
],
[
[
1419,
6,
6799
],
[
6799,
... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alfentanil"
]
],
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fentanyl"
],
[
"Fentanyl",
"{u} (Compound... | Imatinib may lead to a major life threatening interaction when taken with Fentanyl and Fentanyl (Compound) resembles Alfentanil (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Sufentanil and Sufentanil (Compound) resembles Alfentanil (Compound)
Imatinib (Compound) bin... |
DB01035 | DB01075 | 1,401 | 1,376 | [
"DDInter1524",
"DDInter569"
] | Procainamide | Diphenhydramine | A derivative of procaine with less CNS action. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1401,
24,
1376
]
],
[
[
1401,
64,
11
],
[
11,
1,
1376
]
],
[
[
1401,
25,
401
],
[
401,
24,
1376
]
],
[
[
1401,
64,
888
],
[
888,
... | [
[
[
"Procainamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
],
[
"T... | Procainamide may lead to a major life threatening interaction when taken with Toremifene and Toremifene (Compound) resembles Diphenhydramine (Compound)
Procainamide may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate disea... |
DB00851 | DB12674 | 611 | 975 | [
"DDInter463",
"DDInter1105"
] | Dacarbazine | Lurbinectedin | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
611,
24,
975
]
],
[
[
611,
24,
1488
],
[
1488,
24,
975
]
],
[
[
611,
63,
372
],
[
372,
24,
975
]
],
[
[
611,
64,
1648
],
[
1648,
... | [
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
... | Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine an... |
DB00026 | DB12498 | 1,184 | 76 | [
"DDInter94",
"DDInter1238"
] | Anakinra | Mogamulizumab | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Mogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become canc... | Moderate | 1 | [
[
[
1184,
24,
76
]
],
[
[
1184,
23,
1461
],
[
1461,
23,
76
]
],
[
[
1184,
24,
1531
],
[
1531,
24,
76
]
],
[
[
1184,
24,
987
],
[
987,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mogamulizumab"
]
],
[
[
"Anakinra",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Anakinra may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Mogamulizumab
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab ... |
DB08871 | DB12010 | 36 | 214 | [
"DDInter666",
"DDInter785"
] | Eribulin | Fostamatinib | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
36,
24,
214
]
],
[
[
36,
25,
976
],
[
976,
24,
214
]
],
[
[
36,
63,
51
],
[
51,
24,
214
]
],
[
[
36,
64,
924
],
[
924,
24,
... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Eribulin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitinib... | Eribulin may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may ca... |
DB00627 | DB08870 | 265 | 850 | [
"DDInter1286",
"DDInter228"
] | Niacin | Brentuximab vedotin | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
265,
24,
850
]
],
[
[
265,
24,
267
],
[
267,
24,
850
]
],
[
[
265,
63,
245
],
[
245,
24,
850
]
],
[
[
265,
24,
1344
],
[
1344,
6... | [
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
[
... | Niacin may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Niacin may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glim... |
DB00005 | DB15965 | 1,057 | 1,330 | [
"DDInter687",
"DDInter1270"
] | Etanercept | Naxitamab | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Major | 2 | [
[
[
1057,
25,
1330
]
],
[
[
1057,
23,
1193
],
[
1193,
23,
1330
]
],
[
[
1057,
25,
1532
],
[
1532,
24,
1330
]
],
[
[
1057,
24,
14
],
[
14,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naxitamab"
]
],
[
[
"Etanercept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc gluc... | Etanercept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Naxitamab
Etanercept may lead to a major life threatening interaction when taken with Ifosfamide and Ifosfamide may cau... |
DB00146 | DB00776 | 160 | 1,335 | [
"DDInter265",
"DDInter1360"
] | Calcifediol | Oxcarbazepine | The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties. | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
160,
24,
1335
]
],
[
[
160,
24,
1605
],
[
1605,
1,
1335
]
],
[
[
160,
36,
386
],
[
386,
24,
1335
]
],
[
[
160,
25,
1098
],
[
1098,
... | [
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
],
... | Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Oxcarbazepine (Compound)
Calcifediol (Compound) resembles Cholecalciferol (Compound) and Calcifediol may lead to a major life threatening interaction when taken with Cholecalciferol... |
DB00252 | DB00736 | 362 | 660 | [
"DDInter1460",
"DDInter676"
] | Phenytoin | Esomeprazole | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Moderate | 1 | [
[
[
362,
24,
660
]
],
[
[
362,
6,
8374
],
[
8374,
45,
660
]
],
[
[
362,
21,
28785
],
[
28785,
60,
660
]
],
[
[
362,
25,
263
],
[
263,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esomeprazole"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Phenytoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Esomeprazole (Compound)
Phenytoin (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Esomeprazole (Compound)
Phenytoin may lead to a major life threatening interaction when taken with Axitinib and Axitinib may... |
DB00264 | DB00959 | 88 | 1,486 | [
"DDInter1200",
"DDInter1191"
] | Metoprolol | Methylprednisolone | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
88,
24,
1486
]
],
[
[
88,
24,
175
],
[
175,
40,
1486
]
],
[
[
88,
24,
167
],
[
167,
1,
1486
]
],
[
[
88,
6,
4973
],
[
4973,
45,
... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles ... |
DB00039 | DB01229 | 1,253 | 973 | [
"DDInter1380",
"DDInter1378"
] | Palifermin | Paclitaxel (protein-bound) | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
1253,
24,
973
]
],
[
[
1253,
24,
310
],
[
310,
63,
973
]
],
[
[
1253,
24,
134
],
[
134,
24,
973
]
],
[
[
1253,
63,
491
],
[
491,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Paliferm... |
DB00692 | DB01143 | 274 | 923 | [
"DDInter1448",
"DDInter65"
] | Phentolamine | Amifostine | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
274,
24,
923
]
],
[
[
274,
18,
10375
],
[
10375,
57,
923
]
],
[
[
274,
21,
28921
],
[
28921,
60,
923
]
],
[
[
274,
24,
572
],
[
572,
... | [
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Phentolamine",
"{u} (Compound) downregulates {v} (Gene)",
"RPS4Y1"
],
[
"RPS4Y1",
"{u} (Gene) is downregulated... | Phentolamine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Amifostine (Compound)
Phentolamine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Amifostine (Compound)
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB11901 | DB12674 | 913 | 975 | [
"DDInter107",
"DDInter1105"
] | Apalutamide | Lurbinectedin | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements. It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resi... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Major | 2 | [
[
[
913,
25,
975
]
],
[
[
913,
25,
159
],
[
159,
63,
975
]
],
[
[
913,
63,
1532
],
[
1532,
24,
975
]
],
[
[
913,
64,
1362
],
[
1362,
... | [
[
[
"Apalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Apalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Larotrectinib"
],
[
"Larotrectinib",
... | Apalutamide may lead to a major life threatening interaction when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide... |
DB05015 | DB05679 | 1,077 | 1,683 | [
"DDInter174",
"DDInter1907"
] | Belinostat | Ustekinumab | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
1077,
24,
1683
]
],
[
[
1077,
24,
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],
[
1362,
63,
1683
]
],
[
[
1077,
63,
305
],
[
305,
24,
1683
]
],
[
[
1077,
25,
908
],
[
908,
... | [
[
[
"Belinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Belinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Belinostat may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Belinostat may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia... |
DB01396 | DB09481 | 1,482 | 460 | [
"DDInter553",
"DDInter1113"
] | Digitoxin | Magnesium carbonate | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
1482,
23,
460
]
],
[
[
1482,
40,
1252
],
[
1252,
23,
460
]
],
[
[
1482,
62,
752
],
[
752,
23,
460
]
],
[
[
1482,
63,
1620
],
[
1620,
... | [
[
[
"Digitoxin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Digitoxin",
"{u} (Compound) resembles {v} (Compound)",
"Digoxin"
],
[
"Digoxin",
"{u} may cause a minor in... | Digitoxin (Compound) resembles Digoxin (Compound) and Digoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Digitoxin may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit c... |
DB01602 | DB09481 | 339 | 460 | [
"DDInter159",
"DDInter1113"
] | Bacampicillin | Magnesium carbonate | Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal ac... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
339,
24,
460
]
],
[
[
339,
63,
752
],
[
752,
23,
460
]
],
[
[
339,
63,
1620
],
[
1620,
24,
460
]
],
[
[
339,
24,
286
],
[
286,
2... | [
[
[
"Bacampicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Bacampicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
... | Bacampicillin may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Bacampicillin may cause a moderate interaction that could exacerbate diseases when taken with Tetracyc... |
DB00280 | DB01124 | 494 | 1,411 | [
"DDInter575",
"DDInter1828"
] | Disopyramide | Tolbutamide | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
494,
24,
1411
]
],
[
[
494,
24,
959
],
[
959,
40,
1411
]
],
[
[
494,
63,
245
],
[
245,
40,
1411
]
],
[
[
494,
21,
29222
],
[
29222,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Comp... |
DB00374 | DB04899 | 1,061 | 1,549 | [
"DDInter1852",
"DDInter1282"
] | Treprostinil | Nesiritide | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is a 32 amino acid recombinant human B-type natriuretic peptide. | Moderate | 1 | [
[
[
1061,
24,
1549
]
],
[
[
1061,
24,
1344
],
[
1344,
63,
1549
]
],
[
[
1061,
24,
1053
],
[
1053,
24,
1549
]
],
[
[
1061,
63,
1214
],
[
12... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nesiritide"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nesiritide
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Procarbazin... |
DB00188 | DB00916 | 168 | 112 | [
"DDInter222",
"DDInter1202"
] | Bortezomib | Metronidazole | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Moderate | 1 | [
[
[
168,
24,
112
]
],
[
[
168,
24,
458
],
[
458,
40,
112
]
],
[
[
168,
6,
3486
],
[
3486,
45,
112
]
],
[
[
168,
21,
29028
],
[
29028,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
],
[... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole and Tinidazole (Compound) resembles Metronidazole (Compound)
Bortezomib (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Metronidazole (Compound)
Bortezomib (Compound) causes Encephalopathy (Side Effect) an... |
DB00445 | DB01033 | 322 | 328 | [
"DDInter655",
"DDInter1156"
] | Epirubicin | Mercaptopurine | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Moderate | 1 | [
[
[
322,
24,
328
]
],
[
[
322,
5,
11555
],
[
11555,
44,
328
]
],
[
[
322,
21,
29662
],
[
29662,
60,
328
]
],
[
[
322,
23,
1299
],
[
1299,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
]
],
[
[
"Epirubicin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Di... | Epirubicin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Mercaptopurine (Compound)
Epirubicin (Compound) causes Candida infection (Side Effect) and Candida infection (Side Effect) is caused by Mercaptopurine (Compound)
Epirubicin may cause a minor interaction that can lim... |
DB08881 | DB08899 | 868 | 129 | [
"DDInter1925",
"DDInter649"
] | Vemurafenib | Enzalutamide | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
868,
25,
129
]
],
[
[
868,
64,
918
],
[
918,
1,
129
]
],
[
[
868,
6,
8374
],
[
8374,
45,
129
]
],
[
[
868,
21,
29377
],
[
29377,
... | [
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
],
[
"Bicalutamide",
... | Vemurafenib may lead to a major life threatening interaction when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Vemurafenib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Vemurafenib (Compound) causes Musculoskeletal pain (Side Effect) and Mu... |
DB09280 | DB12457 | 1,604 | 1,180 | [
"DDInter1101",
"DDInter1598"
] | Lumacaftor | Rimegepant | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals. It received FDA approval on February 27, 2020 for the acute treatment migraine headache, and was subsequently approved by the European Commission in April 2022 for both the treatment and prevention of migraines. While several p... | Major | 2 | [
[
[
1604,
25,
1180
]
],
[
[
1604,
25,
741
],
[
741,
24,
1180
]
],
[
[
1604,
63,
292
],
[
292,
24,
1180
]
],
[
[
1604,
24,
1501
],
[
1501,
... | [
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rimegepant"
]
],
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rolapitant"
],
[
"Rolapitant",
"{u} m... | Lumacaftor may lead to a major life threatening interaction when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Rimegepant
Lumacaftor may cause a moderate interaction that could exacerbate diseases when taken with Regorafenib and Regorafenib may caus... |
DB00069 | DB00444 | 367 | 63 | [
"DDInter946",
"DDInter1765"
] | Interferon alfacon-1 | Teniposide | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Moderate | 1 | [
[
[
367,
24,
63
]
],
[
[
367,
24,
147
],
[
147,
62,
63
]
],
[
[
367,
24,
1191
],
[
1191,
63,
63
]
],
[
[
367,
25,
1477
],
[
1477,
63... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teniposide"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblas... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Teniposide
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with L... |
DB00910 | DB09098 | 1,041 | 98 | [
"DDInter1394",
"DDInter1700"
] | Paricalcitol | Somatrem | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1041,
24,
98
]
],
[
[
1041,
24,
159
],
[
159,
63,
98
]
],
[
[
1041,
24,
609
],
[
609,
24,
98
]
],
[
[
1041,
63,
690
],
[
690,
24... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Clarithromyci... |
DB00486 | DB01403 | 1,614 | 9 | [
"DDInter1253",
"DDInter1175"
] | Nabilone | Methotrimeprazine | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
1614,
24,
9
]
],
[
[
1614,
24,
1178
],
[
1178,
40,
9
]
],
[
[
1614,
24,
1164
],
[
1164,
1,
9
]
],
[
[
1614,
24,
401
],
[
401,
24... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
],
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Metho... |
DB08895 | DB11703 | 976 | 405 | [
"DDInter1825",
"DDInter9"
] | Tofacitinib | Acalabrutinib | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
976,
25,
405
]
],
[
[
976,
63,
1051
],
[
1051,
24,
405
]
],
[
[
976,
64,
139
],
[
139,
24,
405
]
],
[
[
976,
25,
951
],
[
951,
2... | [
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Tofacitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
[
... | Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Tofacitinib may lead to a major life threatening interaction when taken with Zidovudine and Zi... |
DB00470 | DB00881 | 530 | 954 | [
"DDInter601",
"DDInter1554"
] | Dronabinol | Quinapril | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Moderate | 1 | [
[
[
530,
24,
954
]
],
[
[
530,
24,
1638
],
[
1638,
1,
954
]
],
[
[
530,
24,
1523
],
[
1523,
40,
954
]
],
[
[
530,
25,
675
],
[
675,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Quinapril (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Quinapril (Compound)
... |
DB06718 | DB09100 | 1,687 | 320 | [
"DDInter1709",
"DDInter1799"
] | Stanozolol | Thyroid, porcine | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
1687,
24,
320
]
],
[
[
1687,
63,
1144
],
[
1144,
24,
320
]
],
[
[
1687,
24,
1296
],
[
1296,
63,
320
]
],
[
[
1687,
64,
126
],
[
126,
... | [
[
[
"Stanozolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Stanozolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
... | Stanozolol may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Thyroid, porcine
Stanozolol may cause a moderate interaction that could exacerbate diseases when taken with Insulin deglu... |
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