drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00206 | DB01156 | 1,245 | 593 | [
"DDInter1582",
"DDInter252"
] | Reserpine | Bupropion | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Moderate | 1 | [
[
[
1245,
24,
593
]
],
[
[
1245,
7,
4519
],
[
4519,
57,
593
]
],
[
[
1245,
18,
6718
],
[
6718,
57,
593
]
],
[
[
1245,
21,
28952
],
[
28952... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
]
],
[
[
"Reserpine",
"{u} (Compound) upregulates {v} (Gene)",
"HDAC6"
],
[
"HDAC6",
"{u} (Gene) is downregulated by {v} (Co... | Reserpine (Compound) upregulates HDAC6 (Gene) and HDAC6 (Gene) is downregulated by Bupropion (Compound)
Reserpine (Compound) downregulates USP22 (Gene) and USP22 (Gene) is downregulated by Bupropion (Compound)
Reserpine (Compound) causes Nightmare (Side Effect) and Nightmare (Side Effect) is caused by Bupropion (Compou... |
DB05294 | DB11952 | 1,069 | 800 | [
"DDInter1917",
"DDInter612"
] | Vandetanib | Duvelisib | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
1069,
24,
800
]
],
[
[
1069,
63,
372
],
[
372,
24,
800
]
],
[
[
1069,
64,
11
],
[
11,
24,
800
]
],
[
[
1069,
25,
1374
],
[
1374,
... | [
[
[
"Vandetanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Vandetanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[
... | Vandetanib may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Vandetanib may lead to a major life threatening interaction when taken with Toremifene and Toremifene may cause... |
DB00443 | DB00712 | 251 | 1,274 | [
"DDInter195",
"DDInter763"
] | Betamethasone | Flurbiprofen | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
251,
24,
1274
]
],
[
[
251,
24,
935
],
[
935,
63,
1274
]
],
[
[
251,
24,
1523
],
[
1523,
24,
1274
]
],
[
[
251,
6,
7720
],
[
7720,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and... |
DB09068 | DB09564 | 1,427 | 1,296 | [
"DDInter1948",
"DDInter930"
] | Vortioxetine | Insulin degludec | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1427,
24,
1296
]
],
[
[
1427,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
1427,
64,
73
],
[
73,
24,
1296
]
],
[
[
1427,
24,
98
],
[
98,
... | [
[
[
"Vortioxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Vortioxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
... | Vortioxetine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Vortioxetine may lead to a major life threatening interaction when taken with Phentermine and Phenterm... |
DB00563 | DB14711 | 663 | 779 | [
"DDInter1174",
"DDInter1680"
] | Methotrexate | Smallpox (Vaccinia) Vaccine, Live | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
663,
25,
779
]
],
[
[
663,
64,
1064
],
[
1064,
25,
779
]
],
[
[
663,
24,
478
],
[
478,
25,
779
]
],
[
[
663,
25,
1377
],
[
1377,
... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
... | Methotrexate may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib ... |
DB00748 | DB00906 | 662 | 1,567 | [
"DDInter297",
"DDInter1801"
] | Carbinoxamine | Tiagabine | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. | Moderate | 1 | [
[
[
662,
24,
1567
]
],
[
[
662,
6,
8374
],
[
8374,
45,
1567
]
],
[
[
662,
21,
28658
],
[
28658,
60,
1567
]
],
[
[
662,
63,
530
],
[
530,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiagabine"
]
],
[
[
"Carbinoxamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Carbinoxamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tiagabine (Compound)
Carbinoxamine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Tiagabine (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and... |
DB01242 | DB09472 | 1,237 | 1,383 | [
"DDInter410",
"DDInter1693"
] | Clomipramine | Sodium sulfate | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1237,
24,
1383
]
],
[
[
1237,
63,
609
],
[
609,
24,
1383
]
],
[
[
1237,
1,
146
],
[
146,
24,
1383
]
],
[
[
1237,
24,
1342
],
[
1342,
... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
... | Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Clomipramine (Compound) resembles Propiomazine (Compound) and Propiomazine may cause a moderate in... |
DB00443 | DB00594 | 251 | 863 | [
"DDInter195",
"DDInter68"
] | Betamethasone | Amiloride | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions... | Moderate | 1 | [
[
[
251,
24,
863
]
],
[
[
251,
18,
2730
],
[
2730,
45,
863
]
],
[
[
251,
21,
29196
],
[
29196,
60,
863
]
],
[
[
251,
63,
1648
],
[
1648,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiloride"
]
],
[
[
"Betamethasone",
"{u} (Compound) downregulates {v} (Gene)",
"PLAU"
],
[
"PLAU",
"{u} (Gene) is bound by {v} (Co... | Betamethasone (Compound) downregulates PLAU (Gene) and PLAU (Gene) is bound by Amiloride (Compound)
Betamethasone (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Amiloride (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Al... |
DB00060 | DB01211 | 912 | 609 | [
"DDInter947",
"DDInter393"
] | Interferon beta-1a | Clarithromycin | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
912,
24,
609
]
],
[
[
912,
24,
1570
],
[
1570,
24,
609
]
],
[
[
912,
24,
600
],
[
600,
23,
609
]
],
[
[
912,
24,
1627
],
[
1627,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithro... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00582 | DB04868 | 1,622 | 478 | [
"DDInter1946",
"DDInter1293"
] | Voriconazole | Nilotinib | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1622,
25,
478
]
],
[
[
1622,
25,
1468
],
[
1468,
63,
478
]
],
[
[
1622,
6,
6017
],
[
6017,
45,
478
]
],
[
[
1622,
21,
28963
],
[
28963... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
],
[
"Ponatinib",
"{u} ... | Voriconazole may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Voriconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Voriconazole (Compound) causes An... |
DB01367 | DB09241 | 1,163 | 1,629 | [
"DDInter1572",
"DDInter1186"
] | Rasagiline | Methylene blue | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1163,
25,
1629
]
],
[
[
1163,
63,
1148
],
[
1148,
24,
1629
]
],
[
[
1163,
24,
31
],
[
31,
24,
1629
]
],
[
[
1163,
63,
73
],
[
73,
... | [
[
[
"Rasagiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Rasagiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
"Isop... | Rasagiline may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Rasagiline may cause a moderate interaction that could exacerbate diseases when taken with Xylometazolin... |
DB01377 | DB06410 | 1,283 | 1,196 | [
"DDInter1119",
"DDInter595"
] | Magnesium oxide | Doxercalciferol | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. Doxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney d... | Moderate | 1 | [
[
[
1283,
24,
1196
]
],
[
[
1283,
63,
362
],
[
362,
24,
1196
]
],
[
[
1283,
24,
853
],
[
853,
63,
1196
]
],
[
[
1283,
62,
1252
],
[
1252,
... | [
[
[
"Magnesium oxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxercalciferol"
]
],
[
[
"Magnesium oxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
... | Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Doxercalciferol
Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesiu... |
DB06343 | DB11827 | 1,379 | 433 | [
"DDInter1766",
"DDInter669"
] | Teprotumumab | Ertugliflozin | Teprotumumab is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor. Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016 and was approved by th... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1379,
24,
433
]
],
[
[
1379,
63,
959
],
[
959,
24,
433
]
],
[
[
1379,
24,
1296
],
[
1296,
24,
433
]
],
[
[
1379,
63,
959
],
[
959,
... | [
[
[
"Teprotumumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Teprotumumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Teprotumumab may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Teprotumumab may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec... |
DB00252 | DB08901 | 362 | 1,468 | [
"DDInter1460",
"DDInter1492"
] | Phenytoin | Ponatinib | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
362,
24,
1468
]
],
[
[
362,
25,
478
],
[
478,
24,
1468
]
],
[
[
362,
6,
3486
],
[
3486,
45,
1468
]
],
[
[
362,
7,
18446
],
[
18446,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
],
[
"Nilotinib",
... | Phenytoin may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Phenytoin (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ponatinib (Compound)
Phenytoin (Compound) upregulates IL1R2 ... |
DB00486 | DB04953 | 1,614 | 495 | [
"DDInter1253",
"DDInter708"
] | Nabilone | Ezogabine | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Moderate | 1 | [
[
[
1614,
24,
495
]
],
[
[
1614,
21,
28997
],
[
28997,
60,
495
]
],
[
[
1614,
24,
662
],
[
662,
24,
495
]
],
[
[
1614,
63,
13
],
[
13,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ezogabine"
]
],
[
[
"Nabilone",
"{u} (Compound) causes {v} (Side Effect)",
"Ill-defined disorder"
],
[
"Ill-defined disorder",
"{u} (Sid... | Nabilone (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Ezogabine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases ... |
DB00313 | DB00682 | 556 | 126 | [
"DDInter1913",
"DDInter1951"
] | Valproic acid | Warfarin | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
556,
24,
126
]
],
[
[
556,
24,
1376
],
[
1376,
40,
126
]
],
[
[
556,
6,
3486
],
[
3486,
45,
126
]
],
[
[
556,
62,
168
],
[
168,
... | [
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],... | Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Warfarin (Compound)
Valproic acid (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Warfarin (Compound)
Valproic acid may cause a minor interaction that can l... |
DB00599 | DB00795 | 682 | 50 | [
"DDInter1795",
"DDInter1725"
] | Thiopental | Sulfasalazine | A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does no... | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Minor | 0 | [
[
[
682,
23,
50
]
],
[
[
682,
24,
1074
],
[
1074,
63,
50
]
],
[
[
682,
25,
126
],
[
126,
25,
50
]
],
[
[
682,
24,
1074
],
[
1074,
63... | [
[
[
"Thiopental",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Thiopental",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
],
[... | Thiopental may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123 and Iodide I-123 may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine
Thiopental may lead to a major life threatening interaction when taken with Warfarin and Warfarin may lea... |
DB00582 | DB00860 | 1,622 | 891 | [
"DDInter1946",
"DDInter1513"
] | Voriconazole | Prednisolone | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
1622,
24,
891
]
],
[
[
1622,
63,
1351
],
[
1351,
40,
891
]
],
[
[
1622,
25,
175
],
[
175,
40,
891
]
],
[
[
1622,
24,
167
],
[
167,
... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flunisolide"
],
... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Flunisolide and Flunisolide (Compound) resembles Prednisolone (Compound)
Voriconazole may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)... |
DB00417 | DB09420 | 1,667 | 1,074 | [
"DDInter1445",
"DDInter953"
] | Phenoxymethylpenicillin | Iodide I-123 | Phenoxymethylpenicillin is a narrow spectrum antibiotic also commonly referred to as Penicillin V or Penicillin VK. It is a phenoxymethyl analog of Penicillin G, or [benzylpenicillin]. An orally active naturally penicillin, phenoxymethylpenicillin is used to treat mild to moderate infections in the respiratory tract, s... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1667,
24,
1074
]
],
[
[
1667,
40,
339
],
[
339,
24,
1074
]
],
[
[
1667,
24,
126
],
[
126,
24,
1074
]
],
[
[
1667,
1,
1681
],
[
1681,
... | [
[
[
"Phenoxymethylpenicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Phenoxymethylpenicillin",
"{u} (Compound) resembles {v} (Compound)",
"Bacampicillin"
],
[
"Bacampicilli... | Phenoxymethylpenicillin (Compound) resembles Bacampicillin (Compound) and Bacampicillin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Phenoxymethylpenicillin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a m... |
DB00687 | DB10989 | 870 | 496 | [
"DDInter747",
"DDInter858"
] | Fludrocortisone | Hepatitis A Vaccine | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
870,
24,
496
]
],
[
[
870,
24,
4
],
[
4,
24,
496
]
],
[
[
870,
1,
175
],
[
175,
24,
496
]
],
[
[
870,
63,
1101
],
[
1101,
24,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetax... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Fludrocortisone (Compound) resembles Triamcinolone (Compound) and Tr... |
DB04951 | DB08820 | 187 | 1,478 | [
"DDInter1477",
"DDInter997"
] | Pirfenidone | Ivacaftor | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
187,
24,
1478
]
],
[
[
187,
24,
271
],
[
271,
62,
1478
]
],
[
[
187,
24,
985
],
[
985,
63,
1478
]
],
[
[
187,
63,
482
],
[
482,
... | [
[
[
"Pirfenidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Pirfenidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirabegron"
],
[
... | Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ivacaftor
Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib and Osimer... |
DB00748 | DB01219 | 662 | 716 | [
"DDInter297",
"DDInter473"
] | Carbinoxamine | Dantrolene | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin. | Moderate | 1 | [
[
[
662,
24,
716
]
],
[
[
662,
6,
8374
],
[
8374,
45,
716
]
],
[
[
662,
21,
28698
],
[
28698,
60,
716
]
],
[
[
662,
24,
1609
],
[
1609,
... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dantrolene"
]
],
[
[
"Carbinoxamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Carbinoxamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dantrolene (Compound)
Carbinoxamine (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Dantrolene (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverin... |
DB00872 | DB09065 | 1,080 | 760 | [
"DDInter438",
"DDInter424"
] | Conivaptan | Cobicistat | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
1080,
25,
760
]
],
[
[
1080,
62,
1101
],
[
1101,
23,
760
]
],
[
[
1080,
23,
1374
],
[
1374,
23,
760
]
],
[
[
1080,
63,
1195
],
[
1195,... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Conivaptan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",... | Conivaptan may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Conivaptan may cause a minor interaction that can limit clinical effects when taken with Abiraterone and Abiraterone... |
DB00682 | DB06718 | 126 | 1,687 | [
"DDInter1951",
"DDInter1709"
] | Warfarin | Stanozolol | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Major | 2 | [
[
[
126,
25,
1687
]
],
[
[
126,
25,
1546
],
[
1546,
1,
1687
]
],
[
[
126,
64,
1561
],
[
1561,
40,
1687
]
],
[
[
126,
25,
984
],
[
984,
... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Stanozolol"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methyltestosterone"
],
[
"Methyltestosterone",
... | Warfarin may lead to a major life threatening interaction when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Stanozolol (Compound)
Warfarin may lead to a major life threatening interaction when taken with Testosterone and Testosterone (Compound) resembles Stanozolol (Compound)
Warfarin may l... |
DB00500 | DB04932 | 24 | 1,564 | [
"DDInter1831",
"DDInter491"
] | Tolmetin | Defibrotide | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Moderate | 1 | [
[
[
24,
24,
1564
]
],
[
[
24,
24,
1039
],
[
1039,
24,
1564
]
],
[
[
24,
40,
886
],
[
886,
24,
1564
]
],
[
[
24,
24,
738
],
[
738,
63... | [
[
[
"Tolmetin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Defibrotide"
]
],
[
[
"Tolmetin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
],
[
... | Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Defibrotide
Tolmetin (Compound) resembles Ketorolac (Compound) and Ketorolac may cause a moderate interaction that ... |
DB00604 | DB01059 | 1,425 | 956 | [
"DDInter385",
"DDInter1313"
] | Cisapride | Norfloxacin | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Major | 2 | [
[
[
1425,
25,
956
]
],
[
[
1425,
25,
872
],
[
872,
40,
956
]
],
[
[
1425,
64,
1176
],
[
1176,
1,
956
]
],
[
[
1425,
25,
1539
],
[
1539,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Norfloxacin"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gemifloxacin"
],
[
"Gemifloxacin",
"{u... | Cisapride may lead to a major life threatening interaction when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Cisapride may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (Compound)
Cisapride may lead to ... |
DB00959 | DB01265 | 1,486 | 1,477 | [
"DDInter1191",
"DDInter1757"
] | Methylprednisolone | Telbivudine | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Moderate | 1 | [
[
[
1486,
24,
1477
]
],
[
[
1486,
63,
139
],
[
139,
1,
1477
]
],
[
[
1486,
21,
28745
],
[
28745,
60,
1477
]
],
[
[
1486,
40,
1220
],
[
122... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telbivudine"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine (Compound) resembles Telbivudine (Compound)
Methylprednisolone (Compound) causes Neuropathy peripheral (Side Effect) and Neuropathy peripheral (Side Effect) is caused by Telbivudine (Compound)
Me... |
DB01309 | DB02546 | 1,254 | 137 | [
"DDInter933",
"DDInter1947"
] | Insulin glulisine | Vorinostat | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new clas... | Moderate | 1 | [
[
[
1254,
24,
137
]
],
[
[
1254,
63,
127
],
[
127,
24,
137
]
],
[
[
1254,
24,
1344
],
[
1344,
63,
137
]
],
[
[
1254,
63,
127
],
[
127,
... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vorinostat"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Miglitol and Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Vorinostat
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Canaglifloz... |
DB00570 | DB08889 | 147 | 350 | [
"DDInter1936",
"DDInter299"
] | Vinblastine | Carfilzomib | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
147,
24,
350
]
],
[
[
147,
18,
6538
],
[
6538,
45,
350
]
],
[
[
147,
6,
4973
],
[
4973,
45,
350
]
],
[
[
147,
21,
28762
],
[
28762,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Vinblastine",
"{u} (Compound) downregulates {v} (Gene)",
"PSMB10"
],
[
"PSMB10",
"{u} (Gene) is bound by {v} (... | Vinblastine (Compound) downregulates PSMB10 (Gene) and PSMB10 (Gene) is bound by Carfilzomib (Compound)
Vinblastine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Carfilzomib (Compound)
Vinblastine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Vinbla... |
DB00564 | DB09278 | 1,236 | 852 | [
"DDInter293",
"DDInter24"
] | Carbamazepine | Activated charcoal | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Moderate | 1 | [
[
[
1236,
24,
852
]
],
[
[
1236,
1,
1302
],
[
1302,
24,
852
]
],
[
[
1236,
40,
1164
],
[
1164,
24,
852
]
],
[
[
1236,
63,
964
],
[
964,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Activated charcoal"
]
],
[
[
"Carbamazepine",
"{u} (Compound) resembles {v} (Compound)",
"Protriptyline"
],
[
"Protriptyline",
"{u}... | Carbamazepine (Compound) resembles Protriptyline (Compound) and Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Activated charcoal
Carbamazepine (Compound) resembles Trimipramine (Compound) and Trimipramine may cause a moderate interaction that could exacerbate diseases whe... |
DB00580 | DB12015 | 311 | 1,033 | [
"DDInter1910",
"DDInter53"
] | Valdecoxib | Alpelisib | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
311,
24,
1033
]
],
[
[
311,
24,
1144
],
[
1144,
24,
1033
]
],
[
[
311,
25,
1510
],
[
1510,
24,
1033
]
],
[
[
311,
63,
1645
],
[
1645,
... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
[
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Valdecoxib may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may... |
DB00283 | DB00647 | 701 | 675 | [
"DDInter395",
"DDInter528"
] | Clemastine | Dextropropoxyphene | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Major | 2 | [
[
[
701,
25,
675
]
],
[
[
701,
63,
494
],
[
494,
1,
675
]
],
[
[
701,
35,
1511
],
[
1511,
63,
675
]
],
[
[
701,
24,
649
],
[
649,
1,... | [
[
[
"Clemastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextropropoxyphene"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
],
[
"... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Dextropropoxyphene (Compound)
Clemastine (Compound) resembles Mepenzolate (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00443 | DB01045 | 251 | 463 | [
"DDInter195",
"DDInter1590"
] | Betamethasone | Rifampicin | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
251,
24,
463
]
],
[
[
251,
24,
690
],
[
690,
40,
463
]
],
[
[
251,
6,
4973
],
[
4973,
45,
463
]
],
[
[
251,
18,
6665
],
[
6665,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin (Compound) resembles Rifampicin (Compound)
Betamethasone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rifampicin (Compound)
Betamethasone (Compound) downregulates TIMP1 (Gene) and TIMP1 (G... |
DB01173 | DB09488 | 358 | 103 | [
"DDInter1349",
"DDInter23"
] | Orphenadrine | Acrivastine | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
358,
24,
103
]
],
[
[
358,
1,
1405
],
[
1405,
24,
103
]
],
[
[
358,
63,
85
],
[
85,
24,
103
]
],
[
[
358,
74,
1264
],
[
1264,
24... | [
[
[
"Orphenadrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Orphenadrine",
"{u} (Compound) resembles {v} (Compound)",
"Cyclobenzaprine"
],
[
"Cyclobenzaprine",
"{u} may ... | Orphenadrine (Compound) resembles Cyclobenzaprine (Compound) and Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction... |
DB00422 | DB01364 | 895 | 22 | [
"DDInter1189",
"DDInter650"
] | Methylphenidate | Ephedrine | Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cogni... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
895,
24,
22
]
],
[
[
895,
40,
904
],
[
904,
1,
22
]
],
[
[
895,
24,
1445
],
[
1445,
1,
22
]
],
[
[
895,
6,
7390
],
[
7390,
45,
... | [
[
[
"Methylphenidate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Methylphenidate",
"{u} (Compound) resembles {v} (Compound)",
"Cyclandelate"
],
[
"Cyclandelate",
"{u} (Compo... | Methylphenidate (Compound) resembles Cyclandelate (Compound) and Cyclandelate (Compound) resembles Ephedrine (Compound)
Methylphenidate may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine (Compound) resembles Ephedrine (Compound)
Methylphenidate (Compound)... |
DB01276 | DB15093 | 123 | 1,654 | [
"DDInter706",
"DDInter1698"
] | Exenatide | Somapacitan | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
123,
24,
1654
]
],
[
[
123,
63,
168
],
[
168,
23,
1654
]
],
[
[
123,
63,
176
],
[
176,
24,
1654
]
],
[
[
123,
24,
1019
],
[
1019,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Ins... |
DB01259 | DB12015 | 392 | 1,033 | [
"DDInter1024",
"DDInter53"
] | Lapatinib | Alpelisib | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
392,
24,
1033
]
],
[
[
392,
23,
1135
],
[
1135,
23,
1033
]
],
[
[
392,
24,
154
],
[
154,
24,
1033
]
],
[
[
392,
64,
576
],
[
576,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Lapatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"N... | Lapatinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Alpelisib
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone and Lurasidone may ... |
DB00065 | DB00916 | 581 | 112 | [
"DDInter923",
"DDInter1202"
] | Infliximab | Metronidazole | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Moderate | 1 | [
[
[
581,
24,
112
]
],
[
[
581,
24,
458
],
[
458,
40,
112
]
],
[
[
581,
24,
996
],
[
996,
62,
112
]
],
[
[
581,
25,
51
],
[
51,
23,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
],
[... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole and Tinidazole (Compound) resembles Metronidazole (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline and Bedaquiline may cause a minor interaction that can... |
DB00278 | DB01009 | 291 | 935 | [
"DDInter117",
"DDInter1009"
] | Argatroban | Ketoprofen | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
291,
24,
935
]
],
[
[
291,
24,
1274
],
[
1274,
24,
935
]
],
[
[
291,
24,
1263
],
[
1263,
1,
935
]
],
[
[
291,
21,
28821
],
[
28821,
... | [
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[
... | Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen
Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bro... |
DB00418 | DB00539 | 536 | 11 | [
"DDInter1650",
"DDInter1837"
] | Secobarbital | Toremifene | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Moderate | 1 | [
[
[
536,
24,
11
]
],
[
[
536,
63,
1594
],
[
1594,
40,
11
]
],
[
[
536,
24,
1376
],
[
1376,
40,
11
]
],
[
[
536,
6,
7950
],
[
7950,
4... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Toremifene"
]
],
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine (Compound) resembles Toremifene (Compound)
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Toremife... |
DB00445 | DB00982 | 322 | 1,517 | [
"DDInter655",
"DDInter991"
] | Epirubicin | Isotretinoin | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Moderate | 1 | [
[
[
322,
24,
1517
]
],
[
[
322,
24,
640
],
[
640,
25,
1517
]
],
[
[
322,
5,
11618
],
[
11618,
44,
1517
]
],
[
[
322,
7,
5182
],
[
5182,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isotretinoin"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acitretin"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Acitretin and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin
Epirubicin (Compound) treats peripheral nervous system neoplasm (Disease) and peripheral nervous system neoplasm (Disease) is t... |
DB00776 | DB11703 | 1,335 | 405 | [
"DDInter1360",
"DDInter9"
] | Oxcarbazepine | Acalabrutinib | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
1335,
24,
405
]
],
[
[
1335,
63,
1324
],
[
1324,
24,
405
]
],
[
[
1335,
62,
1101
],
[
1101,
24,
405
]
],
[
[
1335,
24,
951
],
[
951,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
... | Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Oxcarbazepine may cause a minor interaction that can limit clinical effects when taken with Bexarotene... |
DB00352 | DB01206 | 482 | 37 | [
"DDInter1814",
"DDInter1086"
] | Tioguanine | Lomustine | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
482,
24,
37
]
],
[
[
482,
5,
11555
],
[
11555,
44,
37
]
],
[
[
482,
21,
28722
],
[
28722,
60,
37
]
],
[
[
482,
63,
1176
],
[
1176,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Tioguanine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease... | Tioguanine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Lomustine (Compound)
Tioguanine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lomustine (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken... |
DB06718 | DB09061 | 1,687 | 1,627 | [
"DDInter1709",
"DDInter284"
] | Stanozolol | Cannabidiol | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
1687,
24,
1627
]
],
[
[
1687,
24,
384
],
[
384,
23,
1627
]
],
[
[
1687,
24,
1613
],
[
1613,
63,
1627
]
],
[
[
1687,
63,
267
],
[
267,
... | [
[
[
"Stanozolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Stanozolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
... | Stanozolol may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Stanozolol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a ... |
DB00081 | DB00374 | 273 | 1,061 | [
"DDInter1838",
"DDInter1852"
] | Tositumomab | Treprostinil | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Major | 2 | [
[
[
273,
25,
1061
]
],
[
[
273,
25,
885
],
[
885,
40,
1061
]
],
[
[
273,
23,
539
],
[
539,
62,
1061
]
],
[
[
273,
64,
582
],
[
582,
... | [
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Treprostinil"
]
],
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epoprostenol"
],
[
"Epoprostenol",
... | Tositumomab may lead to a major life threatening interaction when taken with Epoprostenol and Epoprostenol (Compound) resembles Treprostinil (Compound)
Tositumomab may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical ef... |
DB00250 | DB01612 | 10 | 1,637 | [
"DDInter475",
"DDInter92"
] | Dapsone | Amyl Nitrite | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
10,
24,
1637
]
],
[
[
10,
24,
612
],
[
612,
24,
1637
]
],
[
[
10,
25,
695
],
[
695,
24,
1637
]
],
[
[
10,
25,
490
],
[
490,
25,
... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verteporfin"
],
[
... | Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Verteporfin and Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Dapsone may lead to a major life threatening interaction when taken with Clozapine and Clozapine may cause a mo... |
DB00402 | DB01075 | 1,407 | 1,376 | [
"DDInter685",
"DDInter569"
] | Eszopiclone | Diphenhydramine | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1407,
24,
1376
]
],
[
[
1407,
24,
649
],
[
649,
63,
1376
]
],
[
[
1407,
24,
128
],
[
128,
24,
1376
]
],
[
[
1407,
63,
1594
],
[
1594,
... | [
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
... | Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Dexbromphenira... |
DB00424 | DB01142 | 19 | 1,264 | [
"DDInter896",
"DDInter593"
] | Hyoscyamine | Doxepin | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
19,
24,
1264
]
],
[
[
19,
63,
508
],
[
508,
24,
1264
]
],
[
[
19,
24,
401
],
[
401,
24,
1264
]
],
[
[
19,
24,
1405
],
[
1405,
25... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Prometh... |
DB06176 | DB09065 | 1,342 | 760 | [
"DDInter1616",
"DDInter424"
] | Romidepsin | Cobicistat | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1342,
24,
760
]
],
[
[
1342,
63,
479
],
[
479,
23,
760
]
],
[
[
1342,
64,
1230
],
[
1230,
23,
760
]
],
[
[
1342,
24,
938
],
[
938,
... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
... | Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Romidepsin may lead to a major life threatening interaction when taken with Citalopram and Citalopram may cause a mi... |
DB11113 | DB11915 | 657 | 1,293 | [
"DDInter307",
"DDInter1909"
] | Castor oil | Valbenazine | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of, which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic,... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
657,
24,
1293
]
],
[
[
657,
63,
521
],
[
521,
24,
1293
]
],
[
[
657,
24,
927
],
[
927,
24,
1293
]
],
[
[
657,
24,
484
],
[
484,
... | [
[
[
"Castor oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Castor oil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Castor oil may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine
Castor oil may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encora... |
DB00357 | DB04855 | 1,051 | 540 | [
"DDInter71",
"DDInter602"
] | Aminoglutethimide | Dronedarone | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Moderate | 1 | [
[
[
1051,
24,
540
]
],
[
[
1051,
6,
8374
],
[
8374,
45,
540
]
],
[
[
1051,
21,
28703
],
[
28703,
60,
540
]
],
[
[
1051,
24,
466
],
[
466,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {... | Aminoglutethimide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dronedarone (Compound)
Aminoglutethimide (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Dronedarone (Compound)
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00188 | DB00834 | 168 | 932 | [
"DDInter222",
"DDInter1215"
] | Bortezomib | Mifepristone | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Moderate | 1 | [
[
[
168,
24,
932
]
],
[
[
168,
6,
12523
],
[
12523,
45,
932
]
],
[
[
168,
18,
2884
],
[
2884,
46,
932
]
],
[
[
168,
7,
7669
],
[
7669,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mifepristone"
]
],
[
[
"Bortezomib",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)... | Bortezomib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mifepristone (Compound)
Bortezomib (Compound) downregulates ECH1 (Gene) and ECH1 (Gene) is upregulated by Mifepristone (Compound)
Bortezomib (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Mifepristone (Compound)
Bortezomib (... |
DB00490 | DB01114 | 946 | 272 | [
"DDInter254",
"DDInter362"
] | Buspirone | Chlorpheniramine | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
946,
24,
272
]
],
[
[
946,
24,
849
],
[
849,
63,
272
]
],
[
[
946,
63,
128
],
[
128,
24,
272
]
],
[
[
946,
6,
12523
],
[
12523,
... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramin... |
DB00488 | DB10343 | 196 | 962 | [
"DDInter57",
"DDInter160"
] | Altretamine | Bacillus calmette-guerin substrain tice live antigen | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
196,
25,
962
]
],
[
[
196,
64,
1057
],
[
1057,
25,
962
]
],
[
[
196,
24,
270
],
[
270,
64,
962
]
],
[
[
196,
24,
1362
],
[
1362,
... | [
[
[
"Altretamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Altretamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Altretamine may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Altretamine may cause a moderate interaction that could exacerbate diseases when taken with Ocreliz... |
DB00969 | DB13179 | 2 | 68 | [
"DDInter52",
"DDInter1882"
] | Alosetron | Troleandomycin | Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US marke... | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
2,
24,
68
]
],
[
[
2,
24,
412
],
[
412,
24,
68
]
],
[
[
2,
63,
723
],
[
723,
24,
68
]
],
[
[
2,
24,
985
],
[
985,
25,
68
... | [
[
[
"Alosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Alosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
],
[... | Alosetron may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline and Eluxadoline may cause a moderate interaction that could exacerbate diseases when taken with Troleandomycin
Alosetron may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Ap... |
DB05676 | DB11932 | 1,513 | 327 | [
"DDInter111",
"DDInter3"
] | Apremilast | Abametapir (topical) | Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
1513,
24,
327
]
],
[
[
1513,
24,
124
],
[
124,
63,
327
]
],
[
[
1513,
63,
1101
],
[
1101,
24,
327
]
],
[
[
1513,
24,
868
],
[
868,
... | [
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
],
[
... | Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Apremilast m... |
DB00373 | DB00712 | 461 | 1,274 | [
"DDInter1809",
"DDInter763"
] | Timolol | Flurbiprofen | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
461,
24,
1274
]
],
[
[
461,
21,
28769
],
[
28769,
60,
1274
]
],
[
[
461,
24,
752
],
[
752,
23,
1274
]
],
[
[
461,
24,
1411
],
[
1411,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Timolol",
"{u} (Compound) causes {v} (Side Effect)",
"Feeling abnormal"
],
[
"Feeling abnormal",
"{u} (Side Effec... | Timolol (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Flurbiprofen (Compound)
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with... |
DB09143 | DB12332 | 313 | 1,619 | [
"DDInter1701",
"DDInter1626"
] | Sonidegib | Rucaparib | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
313,
24,
1619
]
],
[
[
313,
64,
307
],
[
307,
23,
1619
]
],
[
[
313,
64,
1419
],
[
1419,
24,
1619
]
],
[
[
313,
63,
1213
],
[
1213,
... | [
[
[
"Sonidegib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Sonidegib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Modafinil"
],
[
"Modafinil",
... | Sonidegib may lead to a major life threatening interaction when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Sonidegib may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a moderate interaction tha... |
DB00697 | DB08871 | 876 | 36 | [
"DDInter1821",
"DDInter666"
] | Tizanidine | Eribulin | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
876,
24,
36
]
],
[
[
876,
63,
1424
],
[
1424,
24,
36
]
],
[
[
876,
24,
820
],
[
820,
24,
36
]
],
[
[
876,
64,
268
],
[
268,
24,
... | [
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
[
"... | Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine m... |
DB00350 | DB00962 | 1,214 | 1,639 | [
"DDInter1226",
"DDInter1957"
] | Minoxidil | Zaleplon | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Zaleplon is a sedative/hypnotic, mainly used for insomnia. It is known as a nonbenzodiazepine hypnotic. Zaleplon interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Zaleplon is a schedule IV drug in the United States. | Moderate | 1 | [
[
[
1214,
24,
1639
]
],
[
[
1214,
24,
891
],
[
891,
23,
1639
]
],
[
[
1214,
24,
1220
],
[
1220,
62,
1639
]
],
[
[
1214,
24,
530
],
[
530,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zaleplon"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone may cause a minor interaction that can limit clinical effects when taken with Zaleplon
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexam... |
DB01230 | DB08870 | 795 | 850 | [
"DDInter1416",
"DDInter228"
] | Pemoline | Brentuximab vedotin | In 2005, the Food and Drug Administration (FDA) withdrew approval for pemoline. In March 2005, Abbott Laboratories (Cylert marketer) had discontinued the production of Cylert arguing economic reasons. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
795,
24,
850
]
],
[
[
795,
63,
267
],
[
267,
24,
850
]
],
[
[
795,
24,
384
],
[
384,
63,
850
]
],
[
[
795,
64,
593
],
[
593,
24,... | [
[
[
"Pemoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Pemoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
... | Pemoline may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Pemoline may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and I... |
DB00615 | DB09054 | 690 | 384 | [
"DDInter1589",
"DDInter905"
] | Rifabutin | Idelalisib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
690,
24,
384
]
],
[
[
690,
25,
1618
],
[
1618,
24,
384
]
],
[
[
690,
24,
891
],
[
891,
24,
384
]
],
[
[
690,
63,
600
],
[
600,
2... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
],
[
"Cabozantin... | Rifabutin may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone may ... |
DB06694 | DB09241 | 31 | 1,629 | [
"DDInter1952",
"DDInter1186"
] | Xylometazoline (nasal) | Methylene blue | Xylometazoline is an alkylbenzene. | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Moderate | 1 | [
[
[
31,
24,
1629
]
],
[
[
31,
63,
1148
],
[
1148,
24,
1629
]
],
[
[
31,
24,
1032
],
[
1032,
63,
1629
]
],
[
[
31,
24,
659
],
[
659,
... | [
[
[
"Xylometazoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylene blue"
]
],
[
[
"Xylometazoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
... | Xylometazoline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Xylometazoline may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methy... |
DB00405 | DB01320 | 128 | 651 | [
"DDInter517",
"DDInter783"
] | Dexbrompheniramine | Fosphenytoin | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
128,
24,
651
]
],
[
[
128,
63,
362
],
[
362,
1,
651
]
],
[
[
128,
63,
999
],
[
999,
24,
651
]
],
[
[
128,
24,
1264
],
[
1264,
24... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may cause a mod... |
DB08881 | DB11901 | 868 | 913 | [
"DDInter1925",
"DDInter107"
] | Vemurafenib | Apalutamide | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
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[
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[
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[
1322,
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[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Vemurafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Vemurafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Vemurafenib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mir... |
DB01050 | DB12130 | 848 | 1,017 | [
"DDInter900",
"DDInter1094"
] | Ibuprofen | Lorlatinib | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
848,
24,
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],
[
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[
590,
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[
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[
976,
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[
[
848,
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],
[
1421,
... | [
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
],
[
... | Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and T... |
DB00472 | DB08901 | 758 | 1,468 | [
"DDInter758",
"DDInter1492"
] | Fluoxetine | Ponatinib | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
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[
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[
12523,
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[
[
758,
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14549
],
[
14549,... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Fluoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
],
[
"Nilotinib",
... | Fluoxetine may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Fluoxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ponatinib (Compound)
Fluoxetine (Compound) downregulates G... |
DB00215 | DB05294 | 1,230 | 1,069 | [
"DDInter388",
"DDInter1917"
] | Citalopram | Vandetanib | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
1230,
25,
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]
],
[
[
1230,
6,
8374
],
[
8374,
45,
1069
]
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[
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1230,
21,
28719
],
[
28719,
60,
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]
],
[
[
1230,
25,
660
],
[
66... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vandeta... | Citalopram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound)
Citalopram (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Vandetanib (Compound)
Citalopram may lead to a major life threatening interaction when taken with Esomeprazole and Esomeprazole may cause a mi... |
DB00881 | DB00912 | 954 | 473 | [
"DDInter1554",
"DDInter1581"
] | Quinapril | Repaglinide | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
954,
24,
473
]
],
[
[
954,
21,
28873
],
[
28873,
60,
473
]
],
[
[
954,
63,
1512
],
[
1512,
24,
473
]
],
[
[
954,
40,
664
],
[
664,
... | [
[
[
"Quinapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Quinapril",
"{u} (Compound) causes {v} (Side Effect)",
"Pancreatitis"
],
[
"Pancreatitis",
"{u} (Side Effect) is... | Quinapril (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Repaglinide (Compound)
Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Re... |
DB00328 | DB00731 | 831 | 1,144 | [
"DDInter921",
"DDInter1269"
] | Indomethacin | Nateglinide | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
831,
24,
1144
]
],
[
[
831,
6,
1829
],
[
1829,
45,
1144
]
],
[
[
831,
21,
28787
],
[
28787,
60,
1144
]
],
[
[
831,
24,
121
],
[
121,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Indomethacin",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
... | Indomethacin (Compound) binds ALB (Gene) and ALB (Gene) is bound by Nateglinide (Compound)
Indomethacin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Nateglinide (Compound)
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine an... |
DB00652 | DB00771 | 234 | 262 | [
"DDInter1421",
"DDInter397"
] | Pentazocine | Clidinium | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Moderate | 1 | [
[
[
234,
24,
262
]
],
[
[
234,
24,
1511
],
[
1511,
63,
262
]
],
[
[
234,
63,
19
],
[
19,
24,
262
]
],
[
[
234,
1,
1359
],
[
1359,
63... | [
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clidinium"
]
],
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hy... |
DB00163 | DB00853 | 1,461 | 1,686 | [
"DDInter1943",
"DDInter1762"
] | Vitamin E | Temozolomide | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Moderate | 1 | [
[
[
1461,
24,
1686
]
],
[
[
1461,
18,
10496
],
[
10496,
57,
1686
]
],
[
[
1461,
24,
970
],
[
970,
24,
1686
]
],
[
[
1461,
24,
37
],
[
37,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Temozolomide"
]
],
[
[
"Vitamin E",
"{u} (Compound) downregulates {v} (Gene)",
"ATP6V1D"
],
[
"ATP6V1D",
"{u} (Gene) is downregulated b... | Vitamin E (Compound) downregulates ATP6V1D (Gene) and ATP6V1D (Gene) is downregulated by Temozolomide (Compound)
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Fluorouracil and Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Temozol... |
DB06228 | DB09030 | 792 | 840 | [
"DDInter1609",
"DDInter1945"
] | Rivaroxaban | Vorapaxar | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
792,
25,
840
]
],
[
[
792,
23,
944
],
[
944,
62,
840
]
],
[
[
792,
63,
765
],
[
765,
24,
840
]
],
[
[
792,
64,
885
],
[
885,
24,... | [
[
[
"Rivaroxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Rivaroxaban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Rivaroxaban may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Vorapaxar
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause ... |
DB00092 | DB06043 | 58 | 1,644 | [
"DDInter40",
"DDInter1328"
] | Alefacept | Olaratumab | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity and blocks ligand binding. It is composed of two heavy chain molecule fragments and 2 light chain fragments. Stu... | Moderate | 1 | [
[
[
58,
24,
1644
]
],
[
[
58,
24,
1531
],
[
1531,
63,
1644
]
],
[
[
58,
63,
1184
],
[
1184,
24,
1644
]
],
[
[
58,
24,
66
],
[
66,
24... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaratumab"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Olaratumab
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra... |
DB00622 | DB09038 | 1,081 | 1,450 | [
"DDInter1287",
"DDInter636"
] | Nicardipine | Empagliflozin | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1081,
24,
1450
]
],
[
[
1081,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
1081,
24,
1486
],
[
1486,
24,
1450
]
],
[
[
1081,
40,
84
],
[
84,
... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Methylpredni... |
DB00662 | DB01200 | 717 | 469 | [
"DDInter1873",
"DDInter243"
] | Trimethobenzamide | Bromocriptine | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Moderate | 1 | [
[
[
717,
24,
469
]
],
[
[
717,
21,
28785
],
[
28785,
60,
469
]
],
[
[
717,
24,
401
],
[
401,
24,
469
]
],
[
[
717,
63,
701
],
[
701,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromocriptine"
]
],
[
[
"Trimethobenzamide",
"{u} (Compound) causes {v} (Side Effect)",
"Muscle spasms"
],
[
"Muscle spasms",
"... | Trimethobenzamide (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Bromocriptine (Compound)
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate dis... |
DB01211 | DB06402 | 609 | 1,079 | [
"DDInter393",
"DDInter1756"
] | Clarithromycin | Telavancin | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Moderate | 1 | [
[
[
609,
24,
1079
]
],
[
[
609,
21,
28680
],
[
28680,
60,
1079
]
],
[
[
609,
62,
112
],
[
112,
23,
1079
]
],
[
[
609,
24,
657
],
[
657,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
]
],
[
[
"Clarithromycin",
"{u} (Compound) causes {v} (Side Effect)",
"Rash"
],
[
"Rash",
"{u} (Side Effect) is caused... | Clarithromycin (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Telavancin (Compound)
Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Telavan... |
DB00041 | DB01165 | 1,648 | 1,539 | [
"DDInter38",
"DDInter1325"
] | Aldesleukin | Ofloxacin | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Minor | 0 | [
[
[
1648,
23,
1539
]
],
[
[
1648,
23,
1467
],
[
1467,
1,
1539
]
],
[
[
1648,
23,
945
],
[
945,
40,
1539
]
],
[
[
1648,
24,
1238
],
[
1238,... | [
[
[
"Aldesleukin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ofloxacin"
]
],
[
[
"Aldesleukin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enoxacin"
],
[
"... | Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Alde... |
DB08868 | DB10343 | 1,011 | 962 | [
"DDInter737",
"DDInter160"
] | Fingolimod | Bacillus calmette-guerin substrain tice live antigen | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
1011,
25,
962
]
],
[
[
1011,
64,
617
],
[
617,
24,
962
]
],
[
[
1011,
64,
1057
],
[
1057,
25,
962
]
],
[
[
1011,
25,
270
],
[
270,
... | [
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Budesonide"
... | Fingolimod may lead to a major life threatening interaction when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Bacillus calmette-guerin substrain tice live antigen
Fingolimod may lead to a major life threatening interaction when taken with Etanercep... |
DB00023 | DB00446 | 305 | 597 | [
"DDInter127",
"DDInter351"
] | Asparaginase Escherichia coli | Chloramphenicol | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Moderate | 1 | [
[
[
305,
24,
597
]
],
[
[
305,
25,
1101
],
[
1101,
23,
597
]
],
[
[
305,
24,
1627
],
[
1627,
62,
597
]
],
[
[
305,
24,
599
],
[
599,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Asparaginase Escherichia coli may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01149 | DB04868 | 851 | 478 | [
"DDInter1274",
"DDInter1293"
] | Nefazodone | Nilotinib | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
851,
25,
478
]
],
[
[
851,
25,
1468
],
[
1468,
63,
478
]
],
[
[
851,
6,
4973
],
[
4973,
45,
478
]
],
[
[
851,
7,
4759
],
[
4759,
... | [
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
],
[
"Ponatinib",
"{u} may ... | Nefazodone may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Nefazodone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nilotinib (Compound)
Nefazodone (Compound) upregulates SERPI... |
DB01095 | DB08889 | 671 | 350 | [
"DDInter769",
"DDInter299"
] | Fluvastatin | Carfilzomib | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
671,
24,
350
]
],
[
[
671,
18,
5795
],
[
5795,
45,
350
]
],
[
[
671,
21,
28762
],
[
28762,
60,
350
]
],
[
[
671,
63,
482
],
[
482,
... | [
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Fluvastatin",
"{u} (Compound) downregulates {v} (Gene)",
"PSMB8"
],
[
"PSMB8",
"{u} (Gene) is bound by {v} (Co... | Fluvastatin (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is bound by Carfilzomib (Compound)
Fluvastatin (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine... |
DB00641 | DB00951 | 467 | 1,072 | [
"DDInter1675",
"DDInter986"
] | Simvastatin | Isoniazid | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
467,
24,
1072
]
],
[
[
467,
6,
8374
],
[
8374,
45,
1072
]
],
[
[
467,
21,
28722
],
[
28722,
60,
1072
]
],
[
[
467,
63,
912
],
[
912,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Simvastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Simvastatin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Isoniazid (Compound)
Simvastatin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Isoniazid (Compound)
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and I... |
DB00023 | DB00584 | 305 | 610 | [
"DDInter127",
"DDInter638"
] | Asparaginase Escherichia coli | Enalapril | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Moderate | 1 | [
[
[
305,
24,
610
]
],
[
[
305,
24,
743
],
[
743,
1,
610
]
],
[
[
305,
24,
954
],
[
954,
40,
610
]
],
[
[
305,
24,
1144
],
[
1144,
63... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril (Compound) resembles Enalapril (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compoun... |
DB10343 | DB11921 | 962 | 1,019 | [
"DDInter160",
"DDInter492"
] | Bacillus calmette-guerin substrain tice live antigen | Deflazacort | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
962,
25,
1019
]
],
[
[
962,
25,
270
],
[
270,
63,
1019
]
],
[
[
962,
64,
629
],
[
629,
24,
1019
]
],
[
[
962,
25,
1316
],
[
1316,
... | [
[
[
"Bacillus calmette-guerin substrain tice live antigen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Bacillus calmette-guerin substrain tice live antigen",
"{u} may lead to a major life threatening interaction w... | Bacillus calmette-guerin substrain tice live antigen may lead to a major life threatening interaction when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Bacillus calmette-guerin substrain tice live antigen may lead to a major life thre... |
DB05676 | DB12035 | 1,513 | 943 | [
"DDInter111",
"DDInter1641"
] | Apremilast | Sarecycline | Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July... | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
1513,
24,
943
]
],
[
[
1513,
24,
1421
],
[
1421,
63,
943
]
],
[
[
1513,
24,
868
],
[
868,
24,
943
]
],
[
[
1513,
24,
1421
],
[
1421,
... | [
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
],
[
... | Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban and Betrixaban may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemu... |
DB00687 | DB01357 | 870 | 890 | [
"DDInter747",
"DDInter1160"
] | Fludrocortisone | Mestranol | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
870,
24,
890
]
],
[
[
870,
24,
35
],
[
35,
40,
890
]
],
[
[
870,
63,
380
],
[
380,
40,
890
]
],
[
[
870,
35,
1546
],
[
1546,
40,... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
],... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol and Quinestrol (Compound) resembles Mestranol (Compound)
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens and Conjugated estrogens (Compound) res... |
DB10429 | DB11730 | 200 | 351 | [
"DDInter282",
"DDInter1588"
] | Candida albicans | Ribociclib | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
200,
24,
351
]
],
[
[
200,
63,
310
],
[
310,
24,
351
]
],
[
[
200,
24,
738
],
[
738,
63,
351
]
],
[
[
200,
24,
1259
],
[
1259,
6... | [
[
[
"Candida albicans",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Candida albicans",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
... | Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib
Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Nirapar... |
DB00834 | DB00836 | 932 | 543 | [
"DDInter1215",
"DDInter1088"
] | Mifepristone | Loperamide | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
932,
24,
543
]
],
[
[
932,
64,
888
],
[
888,
24,
543
]
],
[
[
932,
6,
8374
],
[
8374,
45,
543
]
],
[
[
932,
7,
6314
],
[
6314,
4... | [
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tamoxifen"
],
[
"Tamoxif... | Mifepristone may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Mifepristone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Loperamide (Compound)
Mifepristone (Compound) upregul... |
DB05239 | DB08904 | 866 | 375 | [
"DDInter425",
"DDInter342"
] | Cobimetinib | Certolizumab pegol | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
866,
25,
375
]
],
[
[
866,
24,
200
],
[
200,
63,
375
]
],
[
[
866,
25,
1593
],
[
1593,
24,
375
]
],
[
[
866,
63,
66
],
[
66,
24,... | [
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
],
[
... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Cobimetinib may lead to a major life threatening interaction when taken with Crizotinib and... |
DB00047 | DB04575 | 176 | 35 | [
"DDInter932",
"DDInter1555"
] | Insulin glargine | Quinestrol | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | The 3-cyclopentyl ether of ethinyl estradiol. | Moderate | 1 | [
[
[
176,
24,
35
]
],
[
[
176,
24,
566
],
[
566,
1,
35
]
],
[
[
176,
24,
984
],
[
984,
40,
35
]
],
[
[
176,
24,
1021
],
[
1021,
24,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonorgestrel"... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel and Levonorgestrel (Compound) resembles Quinestrol (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol (Compound) resembles Quinestr... |
DB00619 | DB10316 | 1,419 | 334 | [
"DDInter909",
"DDInter1248"
] | Imatinib | Mumps virus strain B level jeryl lynn live antigen | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1419,
25,
334
]
],
[
[
1419,
24,
617
],
[
617,
24,
334
]
],
[
[
1419,
25,
594
],
[
594,
25,
334
]
],
[
[
1419,
64,
1057
],
[
1057,
... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budeso... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Mumps virus strain B level jeryl lynn live antigen
Imatinib may lead to a major life threatening interaction when taken with ... |
DB00041 | DB00322 | 1,648 | 141 | [
"DDInter38",
"DDInter742"
] | Aldesleukin | Floxuridine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | Moderate | 1 | [
[
[
1648,
24,
141
]
],
[
[
1648,
25,
1064
],
[
1064,
25,
141
]
],
[
[
1648,
23,
872
],
[
872,
62,
141
]
],
[
[
1648,
23,
1176
],
[
1176,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Floxuridine"
]
],
[
[
"Aldesleukin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cladrib... | Aldesleukin may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Floxuridine
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin may cause a minor in... |
DB00153 | DB00615 | 1,331 | 690 | [
"DDInter662",
"DDInter1589"
] | Ergocalciferol | Rifabutin | Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolat... | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Moderate | 1 | [
[
[
1331,
24,
690
]
],
[
[
1331,
24,
463
],
[
463,
1,
690
]
],
[
[
1331,
6,
8374
],
[
8374,
45,
690
]
],
[
[
1331,
21,
28803
],
[
28803,
... | [
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
]
],
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
],
... | Ergocalciferol may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rifampicin (Compound) resembles Rifabutin (Compound)
Ergocalciferol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rifabutin (Compound)
Ergocalciferol (Compound) causes Anaemia (Side Effect) and A... |
DB00814 | DB01249 | 1,171 | 258 | [
"DDInter1143",
"DDInter958"
] | Meloxicam | Iodixanol | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Major | 2 | [
[
[
1171,
25,
258
]
],
[
[
1171,
25,
497
],
[
497,
1,
258
]
],
[
[
1171,
21,
28748
],
[
28748,
60,
258
]
],
[
[
1171,
24,
712
],
[
712,
... | [
[
[
"Meloxicam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
]
],
[
[
"Meloxicam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
],
[
"Iohexol",
"{u} (Compound)... | Meloxicam may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Meloxicam (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Iodixanol (Compound)
Meloxicam may cause a moderate interaction that could exacerbate diseases... |
DB01206 | DB08826 | 37 | 1,292 | [
"DDInter1086",
"DDInter489"
] | Lomustine | Deferiprone | An alkylating agent of value against both hematologic malignancies and solid tumors. | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
37,
25,
1292
]
],
[
[
37,
21,
29549
],
[
29549,
60,
1292
]
],
[
[
37,
63,
482
],
[
482,
25,
1292
]
],
[
[
37,
24,
4
],
[
4,
25,
... | [
[
[
"Lomustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Lomustine",
"{u} (Compound) causes {v} (Side Effect)",
"Osteoarthritis"
],
[
"Osteoarthritis",
"{u} (Side Effect) is caused by ... | Lomustine (Compound) causes Osteoarthritis (Side Effect) and Osteoarthritis (Side Effect) is caused by Deferiprone (Compound)
Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may lead to a major life threatening interaction when taken with Deferiprone
L... |
DB01238 | DB06176 | 673 | 1,342 | [
"DDInter118",
"DDInter1616"
] | Aripiprazole | Romidepsin | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
673,
24,
1342
]
],
[
[
673,
62,
112
],
[
112,
23,
1342
]
],
[
[
673,
63,
485
],
[
485,
24,
1342
]
],
[
[
673,
24,
1616
],
[
1616,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Aripiprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Aripiprazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and... |
DB04845 | DB12010 | 309 | 214 | [
"DDInter1001",
"DDInter785"
] | Ixabepilone | Fostamatinib | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
309,
24,
214
]
],
[
[
309,
25,
976
],
[
976,
24,
214
]
],
[
[
309,
63,
723
],
[
723,
24,
214
]
],
[
[
309,
24,
861
],
[
861,
63,... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Ixabepilone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofac... | Ixabepilone may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may ... |
DB00624 | DB01124 | 1,561 | 1,411 | [
"DDInter1775",
"DDInter1828"
] | Testosterone | Tolbutamide | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1561,
24,
1411
]
],
[
[
1561,
24,
959
],
[
959,
40,
1411
]
],
[
[
1561,
63,
245
],
[
245,
40,
1411
]
],
[
[
1561,
6,
10215
],
[
10215,... | [
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Comp... |
DB04896 | DB06605 | 901 | 1,409 | [
"DDInter1220",
"DDInter108"
] | Milnacipran | Apixaban | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
901,
24,
1409
]
],
[
[
901,
21,
28787
],
[
28787,
60,
1409
]
],
[
[
901,
40,
41
],
[
41,
63,
1409
]
],
[
[
901,
63,
1560
],
[
1560,
... | [
[
[
"Milnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Milnacipran",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is ca... | Milnacipran (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Apixaban (Compound)
Milnacipran (Compound) resembles Levomilnacipran (Compound) and Levo
Milnacipran may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a ... |
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