drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00099 | DB00526 | 440 | 1,555 | [
"DDInter735",
"DDInter1355"
] | Filgrastim | Oxaliplatin | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
440,
24,
1555
]
],
[
[
440,
24,
141
],
[
141,
24,
1555
]
],
[
[
440,
24,
1213
],
[
1213,
63,
1555
]
],
[
[
440,
63,
305
],
[
305,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Floxuridine"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasa... |
DB00342 | DB01242 | 1,181 | 1,237 | [
"DDInter1770",
"DDInter410"
] | Terfenadine | Clomipramine | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
1181,
24,
1237
]
],
[
[
1181,
25,
684
],
[
684,
1,
1237
]
],
[
[
1181,
24,
1164
],
[
1164,
1,
1237
]
],
[
[
1181,
24,
401
],
[
401,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
"Thio... | Terfenadine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (Compound)
T... |
DB00197 | DB01211 | 1,324 | 609 | [
"DDInter1881",
"DDInter393"
] | Troglitazone | Clarithromycin | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1324,
24,
609
]
],
[
[
1324,
24,
1601
],
[
1601,
23,
609
]
],
[
[
1324,
23,
1101
],
[
1101,
23,
609
]
],
[
[
1324,
24,
1627
],
[
1627,... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loratadine"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Loratadine and Loratadine may cause a minor interaction that can limit clinical effects when taken with Clarithromycin
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Be... |
DB00436 | DB00910 | 323 | 1,041 | [
"DDInter179",
"DDInter1394"
] | Bendroflumethiazide | Paricalcitol | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Moderate | 1 | [
[
[
323,
24,
1041
]
],
[
[
323,
63,
386
],
[
386,
25,
1041
]
],
[
[
323,
21,
28785
],
[
28785,
60,
1041
]
],
[
[
323,
40,
1577
],
[
1577,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paricalcitol"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choleca... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Paricalcitol
Bendroflumethiazide (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is cause... |
DB01320 | DB06228 | 651 | 792 | [
"DDInter783",
"DDInter1609"
] | Fosphenytoin | Rivaroxaban | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
651,
25,
792
]
],
[
[
651,
6,
8374
],
[
8374,
45,
792
]
],
[
[
651,
21,
28703
],
[
28703,
60,
792
]
],
[
[
651,
40,
307
],
[
307,
... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Fosphenytoin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Ri... | Fosphenytoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rivaroxaban (Compound)
Fosphenytoin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Fosphenytoin (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that ca... |
DB00196 | DB00370 | 600 | 1,251 | [
"DDInter743",
"DDInter1230"
] | Fluconazole | Mirtazapine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Moderate | 1 | [
[
[
600,
24,
1251
]
],
[
[
600,
6,
6017
],
[
6017,
45,
1251
]
],
[
[
600,
21,
29250
],
[
29250,
60,
1251
]
],
[
[
600,
23,
112
],
[
112,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirtazapine"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound... | Fluconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Mirtazapine (Compound)
Fluconazole (Compound) causes Polyuria (Side Effect) and Polyuria (Side Effect) is caused by Mirtazapine (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and ... |
DB00163 | DB00290 | 1,461 | 329 | [
"DDInter1943",
"DDInter219"
] | Vitamin E | Bleomycin | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Moderate | 1 | [
[
[
1461,
24,
329
]
],
[
[
1461,
62,
58
],
[
58,
24,
329
]
],
[
[
1461,
24,
372
],
[
372,
63,
329
]
],
[
[
1461,
23,
270
],
[
270,
6... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bleomycin"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Alefacept"
],
[
"A... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Bleomycin
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine ... |
DB09100 | DB11126 | 320 | 900 | [
"DDInter1799",
"DDInter276"
] | Thyroid, porcine | Calcium gluconate | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Moderate | 1 | [
[
[
320,
24,
900
]
],
[
[
320,
63,
1231
],
[
1231,
24,
900
]
],
[
[
320,
63,
1283
],
[
1283,
62,
729
],
[
729,
24,
900
]
],
[
[
320,
... | [
[
[
"Thyroid, porcine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Thyroid, porcine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolevame... | Thyroid, porcine may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer and Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Thyroid, porcine may cause a moderate interaction that could exacerbate diseases when taken with Magn... |
DB00222 | DB00489 | 245 | 17 | [
"DDInter825",
"DDInter1704"
] | Glimepiride | Sotalol | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Moderate | 1 | [
[
[
245,
24,
17
]
],
[
[
245,
24,
88
],
[
88,
40,
17
]
],
[
[
245,
21,
29012
],
[
29012,
60,
17
]
],
[
[
245,
24,
417
],
[
417,
23,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoprolol"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Sotalol (Compound)
Glimepiride (Compound) causes Vasodilation procedure (Side Effect) and Vasodilation procedure (Side Effect) is caused by Sotalol (Compound)
Glimepiride may cause ... |
DB01142 | DB06663 | 1,264 | 1,154 | [
"DDInter593",
"DDInter1398"
] | Doxepin | Pasireotide | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
1264,
25,
1154
]
],
[
[
1264,
63,
1314
],
[
1314,
40,
1154
]
],
[
[
1264,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
1264,
62,
112
],
[
1... | [
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desmopressin"
],
[
"Desmopressin"... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin (Compound) resembles Pasireotide (Compound)
Doxepin (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Doxepin may cause a minor interact... |
DB00569 | DB01009 | 553 | 935 | [
"DDInter775",
"DDInter1009"
] | Fondaparinux | Ketoprofen | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Major | 2 | [
[
[
553,
25,
935
]
],
[
[
553,
25,
1274
],
[
1274,
24,
935
]
],
[
[
553,
25,
1263
],
[
1263,
1,
935
]
],
[
[
553,
64,
886
],
[
886,
... | [
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ketoprofen"
]
],
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Flurbiprofen"
],
[
"Flurbiprofen",
... | Fondaparinux may lead to a major life threatening interaction when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen
Fondaparinux may lead to a major life threatening interaction when taken with Bromfenac and Bromfenac (Compound) resemble... |
DB00005 | DB00379 | 1,057 | 143 | [
"DDInter687",
"DDInter1206"
] | Etanercept | Mexiletine | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. | Moderate | 1 | [
[
[
1057,
24,
143
]
],
[
[
1057,
25,
980
],
[
980,
63,
143
]
],
[
[
1057,
24,
608
],
[
608,
24,
143
]
],
[
[
1057,
25,
581
],
[
581,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mexiletine"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tocilizumab"
],
[
"Tocilizum... | Etanercept may lead to a major life threatening interaction when taken with Tocilizumab and Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Mexiletine
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause ... |
DB00531 | DB01165 | 450 | 1,539 | [
"DDInter456",
"DDInter1325"
] | Cyclophosphamide | Ofloxacin | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Minor | 0 | [
[
[
450,
23,
1539
]
],
[
[
450,
62,
1467
],
[
1467,
1,
1539
]
],
[
[
450,
23,
945
],
[
945,
40,
1539
]
],
[
[
450,
23,
739
],
[
739,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ofloxacin"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enoxacin"
],
... | Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Comp... |
DB00363 | DB01259 | 695 | 392 | [
"DDInter419",
"DDInter1024"
] | Clozapine | Lapatinib | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Major | 2 | [
[
[
695,
25,
392
]
],
[
[
695,
6,
4973
],
[
4973,
45,
392
]
],
[
[
695,
23,
112
],
[
112,
23,
392
]
],
[
[
695,
25,
918
],
[
918,
24... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lapatinib"
]
],
[
[
"Clozapine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Lapatinib"
... | Clozapine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Clozapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lapatinib
Clozapine may lead to ... |
DB00831 | DB09080 | 1,178 | 144 | [
"DDInter1866",
"DDInter1331"
] | Trifluoperazine | Olodaterol | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
1178,
24,
144
]
],
[
[
1178,
25,
1011
],
[
1011,
24,
144
]
],
[
[
1178,
1,
695
],
[
695,
24,
144
]
],
[
[
1178,
64,
11
],
[
11,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Trifluoperazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
"... | Trifluoperazine may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Trifluoperazine (Compound) resembles Clozapine (Compound) and Clozapine may cause a moderate interaction that could exacer... |
DB00652 | DB00757 | 234 | 1,166 | [
"DDInter1421",
"DDInter581"
] | Pentazocine | Dolasetron | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
234,
25,
1166
]
],
[
[
234,
63,
19
],
[
19,
40,
1166
]
],
[
[
234,
63,
85
],
[
85,
1,
1166
]
],
[
[
234,
21,
29196
],
[
29196,
6... | [
[
[
"Pentazocine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hyoscya... | Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Dolasetron (Compound)
Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Dolasetron (Compound)
... |
DB09122 | DB11952 | 1,613 | 800 | [
"DDInter1409",
"DDInter612"
] | Peginterferon beta-1a | Duvelisib | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
1613,
24,
800
]
],
[
[
1613,
63,
467
],
[
467,
24,
800
]
],
[
[
1613,
24,
564
],
[
564,
63,
800
]
],
[
[
1613,
24,
351
],
[
351,
... | [
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Peginterferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvas... | Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00704 | DB01076 | 267 | 700 | [
"DDInter1263",
"DDInter133"
] | Naltrexone | Atorvastatin | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Moderate | 1 | [
[
[
267,
24,
700
]
],
[
[
267,
24,
788
],
[
788,
1,
700
]
],
[
[
267,
6,
4973
],
[
4973,
45,
700
]
],
[
[
267,
18,
15501
],
[
15501,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atorvastatin"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin (Compound) resembles Atorvastatin (Compound)
Naltrexone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Atorvastatin (Compound)
Naltrexone (Compound) downregulates CCDC86 (Gene) and CCDC86... |
DB01076 | DB08912 | 700 | 1,040 | [
"DDInter133",
"DDInter462"
] | Atorvastatin | Dabrafenib | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
700,
24,
1040
]
],
[
[
700,
6,
13478
],
[
13478,
45,
1040
]
],
[
[
700,
7,
2969
],
[
2969,
46,
1040
]
],
[
[
700,
18,
1870
],
[
1870,
... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Atorvastatin",
"{u} (Compound) binds {v} (Gene)",
"SLCO1B3"
],
[
"SLCO1B3",
"{u} (Gene) is bound by {v} (Compo... | Atorvastatin (Compound) binds SLCO1B3 (Gene) and SLCO1B3 (Gene) is bound by Dabrafenib (Compound)
Atorvastatin (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Dabrafenib (Compound)
Atorvastatin (Compound) downregulates MYC (Gene) and MYC (Gene) is downregulated by Dabrafenib (Compound)
Atorvast... |
DB00570 | DB15982 | 147 | 1,339 | [
"DDInter1936",
"DDInter193"
] | Vinblastine | Berotralstat | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
147,
24,
1339
]
],
[
[
147,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
147,
24,
283
],
[
283,
23,
1339
]
],
[
[
147,
24,
1213
],
[
1213,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedr... |
DB00480 | DB11791 | 1,668 | 785 | [
"DDInter1035",
"DDInter287"
] | Lenalidomide | Capmatinib | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
1668,
24,
785
]
],
[
[
1668,
63,
482
],
[
482,
24,
785
]
],
[
[
1668,
24,
1320
],
[
1320,
63,
785
]
],
[
[
1668,
24,
850
],
[
850,
... | [
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
],
... | Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Capmatinib
Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elag... |
DB00275 | DB01246 | 217 | 820 | [
"DDInter1330",
"DDInter45"
] | Olmesartan | Alimemazine | Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, w... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
217,
24,
820
]
],
[
[
217,
24,
104
],
[
104,
40,
820
]
],
[
[
217,
24,
401
],
[
401,
24,
820
]
],
[
[
217,
21,
28666
],
[
28666,
... | [
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[... | Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction t... |
DB00281 | DB01589 | 608 | 481 | [
"DDInter1066",
"DDInter1552"
] | Lidocaine | Quazepam | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors a... | Moderate | 1 | [
[
[
608,
24,
481
]
],
[
[
608,
24,
1216
],
[
1216,
1,
481
]
],
[
[
608,
63,
905
],
[
905,
40,
481
]
],
[
[
608,
63,
1174
],
[
1174,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quazepam"
]
],
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
],
[
... | Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Quazepam (Compound)
Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Lorazepam and Lorazepam (Compound) resembles Quazepam (Compound)
Lidocain... |
DB00637 | DB04948 | 1,557 | 1,084 | [
"DDInter128",
"DDInter1083"
] | Astemizole | Lofexidine | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
1557,
24,
1084
]
],
[
[
1557,
23,
112
],
[
112,
23,
1084
]
],
[
[
1557,
24,
774
],
[
774,
63,
1084
]
],
[
[
1557,
24,
688
],
[
688,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Astemizole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Astemizole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lofexidine
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and Degar... |
DB09065 | DB14975 | 760 | 988 | [
"DDInter424",
"DDInter1949"
] | Cobicistat | Voxelotor | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Major | 2 | [
[
[
760,
25,
988
]
],
[
[
760,
24,
466
],
[
466,
23,
988
]
],
[
[
760,
63,
251
],
[
251,
24,
988
]
],
[
[
760,
64,
629
],
[
629,
24,... | [
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voxelotor"
]
],
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Darolutam... | Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Voxelotor
Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Be... |
DB00980 | DB01142 | 969 | 1,264 | [
"DDInter1564",
"DDInter593"
] | Ramelteon | Doxepin | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
969,
24,
1264
]
],
[
[
969,
24,
401
],
[
401,
24,
1264
]
],
[
[
969,
63,
832
],
[
832,
24,
1264
]
],
[
[
969,
24,
649
],
[
649,
... | [
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tri... |
DB01044 | DB13074 | 246 | 877 | [
"DDInter809",
"DDInter1110"
] | Gatifloxacin | Macimorelin | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
246,
25,
877
]
],
[
[
246,
62,
112
],
[
112,
23,
877
]
],
[
[
246,
63,
1479
],
[
1479,
24,
877
]
],
[
[
246,
25,
913
],
[
913,
2... | [
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Gatifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicyli... |
DB00570 | DB11952 | 147 | 800 | [
"DDInter1936",
"DDInter612"
] | Vinblastine | Duvelisib | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
147,
24,
800
]
],
[
[
147,
24,
310
],
[
310,
24,
800
]
],
[
[
147,
24,
1476
],
[
1476,
63,
800
]
],
[
[
147,
63,
663
],
[
663,
2... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Bri... |
DB00603 | DB14568 | 303 | 982 | [
"DDInter1137",
"DDInter1000"
] | Medroxyprogesterone acetate | Ivosidenib | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
303,
24,
982
]
],
[
[
303,
64,
1101
],
[
1101,
23,
982
]
],
[
[
303,
23,
700
],
[
700,
24,
982
]
],
[
[
303,
40,
989
],
[
989,
2... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarote... | Medroxyprogesterone acetate may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Medroxyprogesterone acetate may cause a minor interaction that can limit clinical effects when taken with Atorva... |
DB00026 | DB00294 | 1,184 | 1,336 | [
"DDInter94",
"DDInter701"
] | Anakinra | Etonogestrel | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Moderate | 1 | [
[
[
1184,
24,
1336
]
],
[
[
1184,
24,
566
],
[
566,
1,
1336
]
],
[
[
1184,
24,
873
],
[
873,
40,
1336
]
],
[
[
1184,
25,
581
],
[
581,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etonogestrel"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonorgestrel"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel and Levonorgestrel (Compound) resembles Etonogestrel (Compound)
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Norgestimate and Norgestimate (Compound) resembles Etonogestrel... |
DB00030 | DB01211 | 1,685 | 609 | [
"DDInter934",
"DDInter393"
] | Insulin human | Clarithromycin | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1685,
24,
609
]
],
[
[
1685,
24,
1101
],
[
1101,
23,
609
]
],
[
[
1685,
24,
34
],
[
34,
62,
609
]
],
[
[
1685,
24,
52
],
[
52,
6... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
]... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Clarithromycin
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Fosamprenavir... |
DB00734 | DB09104 | 1,664 | 286 | [
"DDInter1605",
"DDInter1118"
] | Risperidone | Magnesium hydroxide | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1664,
24,
286
]
],
[
[
1664,
24,
820
],
[
820,
23,
286
]
],
[
[
1664,
62,
752
],
[
752,
23,
286
]
],
[
[
1664,
63,
999
],
[
999,
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Risperidone may cause a minor interaction that can limit clinical effects when taken with Cimetidine a... |
DB08908 | DB12240 | 713 | 110 | [
"DDInter564",
"DDInter1485"
] | Dimethyl fumarate | Polatuzumab vedotin | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
713,
24,
110
]
],
[
[
713,
63,
1419
],
[
1419,
24,
110
]
],
[
[
713,
24,
951
],
[
951,
24,
110
]
],
[
[
713,
24,
1619
],
[
1619,
... | [
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imat... | Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedotin
Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Pa... |
DB00563 | DB09061 | 663 | 1,627 | [
"DDInter1174",
"DDInter284"
] | Methotrexate | Cannabidiol | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
663,
24,
1627
]
],
[
[
663,
25,
660
],
[
660,
23,
1627
]
],
[
[
663,
24,
609
],
[
609,
23,
1627
]
],
[
[
663,
63,
600
],
[
600,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Esomeprazole"
],
[
"Eso... | Methotrexate may lead to a major life threatening interaction when taken with Esomeprazole and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithrom... |
DB00197 | DB00877 | 1,324 | 629 | [
"DDInter1881",
"DDInter1678"
] | Troglitazone | Sirolimus | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1324,
24,
629
]
],
[
[
1324,
24,
907
],
[
907,
62,
629
]
],
[
[
1324,
24,
1215
],
[
1215,
24,
629
]
],
[
[
1324,
24,
1476
],
[
1476,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doravirine"
],
[... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Sirolimus
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lan... |
DB08820 | DB08881 | 1,478 | 868 | [
"DDInter997",
"DDInter1925"
] | Ivacaftor | Vemurafenib | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
1478,
24,
868
]
],
[
[
1478,
6,
8374
],
[
8374,
45,
868
]
],
[
[
1478,
54,
19133
],
[
19133,
15,
868
]
],
[
[
1478,
21,
29106
],
[
291... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Ivacaftor",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Ivacaftor (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Ivacaftor (Compound) is included by P-Glycoprotein Inhibitors (Pharmacologic Class) and P-Glycoprotein Inhibitors (Pharmacologic Class) includes Vemurafenib (Compound)
Ivacaftor (Compound) causes Myalgia (Side Effect) and Myal... |
DB04865 | DB06655 | 4 | 5 | [
"DDInter1335",
"DDInter1077"
] | Omacetaxine mepesuccinate | Liraglutide | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
4,
24,
5
]
],
[
[
4,
63,
870
],
[
870,
24,
5
]
],
[
[
4,
24,
637
],
[
637,
63,
5
]
],
[
[
4,
24,
1491
],
[
1491,
24,
5
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate disea... |
DB08880 | DB12026 | 1,510 | 791 | [
"DDInter1771",
"DDInter1950"
] | Teriflunomide | Voxilaprevir | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most c... | Moderate | 1 | [
[
[
1510,
24,
791
]
],
[
[
1510,
25,
26
],
[
26,
24,
791
]
],
[
[
1510,
64,
866
],
[
866,
24,
791
]
],
[
[
1510,
64,
14
],
[
14,
25,... | [
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voxilaprevir"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Afatinib"
],
[
"Afat... | Teriflunomide may lead to a major life threatening interaction when taken with Afatinib and Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Voxilaprevir
Teriflunomide may lead to a major life threatening interaction when taken with Cobimetinib and Cobimetinib may cause a moderat... |
DB01169 | DB11642 | 57 | 938 | [
"DDInter120",
"DDInter1480"
] | Arsenic trioxide | Pitolisant | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Major | 2 | [
[
[
57,
25,
938
]
],
[
[
57,
62,
112
],
[
112,
23,
938
]
],
[
[
57,
24,
28
],
[
28,
24,
938
]
],
[
[
57,
64,
600
],
[
600,
24,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pitolisant"
]
],
[
[
"Arsenic trioxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Bisacod... |
DB00103 | DB05018 | 1,471 | 1,368 | [
"DDInter34",
"DDInter1216"
] | Agalsidase beta | Migalastat | Agalsidase beta is a recombinant human α-galactosidase A similar to [agalsidase alfa]. While patients generally do not experience a clinically significant difference in outcomes between the two drugs, some patients may experience greater benefit with agalsidase beta.[A220228,A220233] Use of agalsidase beta has decrease... | Fabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A). This enzyme is responsible for breaking down glycosphingolipid substrate that, when deficient in patients with Fabry disease, builds up in the blood ves... | Moderate | 1 | [
[
[
1471,
24,
1368
]
]
] | [
[
[
"Agalsidase beta",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Migalastat"
]
]
] | |
DB00056 | DB06372 | 816 | 259 | [
"DDInter814",
"DDInter1594"
] | Gemtuzumab ozogamicin | Rilonacept | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
816,
24,
259
]
],
[
[
816,
24,
1367
],
[
1367,
63,
259
]
],
[
[
816,
24,
482
],
[
482,
24,
259
]
],
[
[
816,
25,
770
],
[
770,
2... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepat... | Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant) and Hepatitis B Vaccine (Recombinant) may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Gemtuzumab ozogamicin may cause a moderate interaction ... |
DB00631 | DB00790 | 372 | 664 | [
"DDInter405",
"DDInter1431"
] | Clofarabine | Perindopril | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Moderate | 1 | [
[
[
372,
24,
664
]
],
[
[
372,
63,
1638
],
[
1638,
1,
664
]
],
[
[
372,
24,
954
],
[
954,
40,
664
]
],
[
[
372,
24,
1058
],
[
1058,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perindopril"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Perindopril (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Perindopril (Comp... |
DB06626 | DB08903 | 263 | 996 | [
"DDInter147",
"DDInter170"
] | Axitinib | Bedaquiline | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Moderate | 1 | [
[
[
263,
24,
996
]
],
[
[
263,
24,
1613
],
[
1613,
63,
996
]
],
[
[
263,
63,
353
],
[
353,
24,
996
]
],
[
[
263,
25,
760
],
[
760,
6... | [
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
]
],
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
],
... | Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline
Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Gr... |
DB00011 | DB00227 | 1,451 | 1,463 | [
"DDInter944",
"DDInter1098"
] | Interferon alfa-n1 | Lovastatin | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Moderate | 1 | [
[
[
1451,
24,
1463
]
],
[
[
1451,
24,
681
],
[
681,
1,
1463
]
],
[
[
1451,
24,
1626
],
[
1626,
63,
1463
]
],
[
[
1451,
24,
1560
],
[
1560,... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lovastatin"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pravastatin... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Pravastatin and Pravastatin (Compound) resembles Lovastatin (Compound)
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab and Elotuzumab may cause a moderate inte... |
DB00727 | DB01075 | 685 | 1,376 | [
"DDInter1304",
"DDInter569"
] | Nitroglycerin | Diphenhydramine | Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure ex... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
685,
24,
1376
]
],
[
[
685,
24,
401
],
[
401,
24,
1376
]
],
[
[
685,
21,
28921
],
[
28921,
60,
1376
]
],
[
[
685,
63,
530
],
[
530,
... | [
[
[
"Nitroglycerin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Nitroglycerin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
... | Nitroglycerin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Nitroglycerin (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Dip... |
DB00046 | DB01136 | 1,179 | 772 | [
"DDInter940",
"DDInter305"
] | Insulin lispro | Carvedilol | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
1179,
24,
772
]
],
[
[
1179,
24,
542
],
[
542,
23,
772
]
],
[
[
1179,
24,
891
],
[
891,
24,
772
]
],
[
[
1179,
24,
1033
],
[
1033,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Carvedilol
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Prednisol... |
DB00860 | DB01001 | 891 | 688 | [
"DDInter1513",
"DDInter1632"
] | Prednisolone | Salbutamol | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Minor | 0 | [
[
[
891,
23,
688
]
],
[
[
891,
23,
455
],
[
455,
24,
688
]
],
[
[
891,
23,
1148
],
[
1148,
63,
688
]
],
[
[
891,
5,
11649
],
[
11649,
... | [
[
[
"Prednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Salbutamol"
]
],
[
[
"Prednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Salmeterol"
],
[
... | Prednisolone may cause a minor interaction that can limit clinical effects when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Prednisolone may cause a minor interaction that can limit clinical effects when taken with Isoprenaline and Isop... |
DB00225 | DB01203 | 457 | 699 | [
"DDInter794",
"DDInter1255"
] | Gadodiamide | Nadolol | Gadodiamide is a linear, non-ionic gadolinium-based contrast agent (GBCA) that is used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels.[A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than nonionic iodinated contrast agent... | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Moderate | 1 | [
[
[
457,
24,
699
]
],
[
[
457,
24,
668
],
[
668,
1,
699
]
],
[
[
457,
21,
28882
],
[
28882,
60,
699
]
],
[
[
457,
40,
808
],
[
808,
... | [
[
[
"Gadodiamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nadolol"
]
],
[
[
"Gadodiamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levobunolol"
],
[
... | Gadodiamide may cause a moderate interaction that could exacerbate diseases when taken with Levobunolol and Levobunolol (Compound) resembles Nadolol (Compound)
Gadodiamide (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Nadolol (Compound)
Gadodiamide ... |
DB00332 | DB01618 | 1,089 | 776 | [
"DDInter970",
"DDInter1239"
] | Ipratropium | Molindone | Ipratropium is a quaternary ammonium derivative of [atropine] that acts as an anticholinergic agent. It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its... | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Moderate | 1 | [
[
[
1089,
24,
776
]
],
[
[
1089,
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],
[
7992,
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],
[
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[
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],
[
[
1089,
18,
12106
],
[
12106,... | [
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Molindone"
]
],
[
[
"Ipratropium",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound)",
... | Ipratropium (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Molindone (Compound)
Ipratropium (Compound) upregulates TIAM1 (Gene) and TIAM1 (Gene) is upregulated by Molindone (Compound)
Ipratropium (Compound) downregulates NT5DC2 (Gene) and NT5DC2 (Gene) is upregulated by Molindone (Compound)
Ipratropium (Com... |
DB00759 | DB09473 | 1,620 | 884 | [
"DDInter1783",
"DDInter918"
] | Tetracycline | Indium In-111 oxyquinoline | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detecte... | Moderate | 1 | [
[
[
1620,
24,
884
]
],
[
[
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1,
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],
[
1572,
24,
884
]
],
[
[
1620,
24,
319
],
[
319,
24,
884
]
],
[
[
1620,
1,
1572
],
[
1572,
... | [
[
[
"Tetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indium In-111 oxyquinoline"
]
],
[
[
"Tetracycline",
"{u} (Compound) resembles {v} (Compound)",
"Demeclocycline"
],
[
"Demeclocycline",
... | Tetracycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Indium In-111 oxyquinoline
Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Amoxicillin and Amoxicillin may cause a m... |
DB00421 | DB00712 | 443 | 1,274 | [
"DDInter1707",
"DDInter763"
] | Spironolactone | Flurbiprofen | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
443,
24,
1274
]
],
[
[
443,
21,
28769
],
[
28769,
60,
1274
]
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[
[
443,
24,
1619
],
[
1619,
63,
1274
]
],
[
[
443,
24,
175
],
[
175,
... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Spironolactone",
"{u} (Compound) causes {v} (Side Effect)",
"Feeling abnormal"
],
[
"Feeling abnormal",
"{... | Spironolactone (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Flurbiprofen (Compound)
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases w... |
DB01177 | DB08901 | 77 | 1,468 | [
"DDInter904",
"DDInter1492"
] | Idarubicin | Ponatinib | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
77,
24,
1468
]
],
[
[
77,
25,
478
],
[
478,
24,
1468
]
],
[
[
77,
6,
12523
],
[
12523,
45,
1468
]
],
[
[
77,
18,
2030
],
[
2030,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
],
[
"Nilotinib",
... | Idarubicin may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Idarubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ponatinib (Compound)
Idarubicin (Compound) downregulates A... |
DB01344 | DB13257 | 1,231 | 260 | [
"DDInter1830",
"DDInter727"
] | Tolevamer | Ferrous sulfate anhydrous | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age. This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation of erythrocytes, also known as red blood cells. Ferrous sulfate is a sy... | Moderate | 1 | [
[
[
1231,
24,
260
]
],
[
[
1231,
24,
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],
[
1114,
23,
260
]
],
[
[
1231,
63,
837
],
[
837,
24,
260
]
],
[
[
1231,
25,
460
],
[
460,
... | [
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous sulfate anhydrous"
]
],
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc sulfate"
... | Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Ferrous sulfate anhydrous
Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Pantop... |
DB06772 | DB08860 | 310 | 788 | [
"DDInter259",
"DDInter1479"
] | Cabazitaxel | Pitavastatin | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
310,
24,
788
]
],
[
[
310,
63,
671
],
[
671,
1,
788
]
],
[
[
310,
63,
700
],
[
700,
40,
788
]
],
[
[
310,
6,
17404
],
[
17404,
4... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastatin (Compound) resembles Pitavastatin... |
DB00013 | DB00691 | 1,255 | 1,058 | [
"DDInter1905",
"DDInter1237"
] | Urokinase | Moexipril | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Moderate | 1 | [
[
[
1255,
24,
1058
]
],
[
[
1255,
24,
1638
],
[
1638,
1,
1058
]
],
[
[
1255,
24,
954
],
[
954,
40,
1058
]
],
[
[
1255,
24,
714
],
[
714,
... | [
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Moexipril"
]
],
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
[
... | Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Moexipril (Compound)
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Moexipril (Compound)
Ur... |
DB00434 | DB01080 | 13 | 855 | [
"DDInter459",
"DDInter1933"
] | Cyproheptadine | Vigabatrin | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Moderate | 1 | [
[
[
13,
24,
855
]
],
[
[
13,
21,
28975
],
[
28975,
60,
855
]
],
[
[
13,
24,
407
],
[
407,
63,
855
]
],
[
[
13,
24,
401
],
[
401,
24,... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vigabatrin"
]
],
[
[
"Cyproheptadine",
"{u} (Compound) causes {v} (Side Effect)",
"Tension"
],
[
"Tension",
"{u} (Side Effect) is ... | Cyproheptadine (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Vigabatrin (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Vigabatrin
Cy... |
DB04855 | DB11978 | 540 | 124 | [
"DDInter602",
"DDInter822"
] | Dronedarone | Glasdegib | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
540,
25,
124
]
],
[
[
540,
25,
1135
],
[
1135,
23,
124
]
],
[
[
540,
62,
112
],
[
112,
23,
124
]
],
[
[
540,
23,
466
],
[
466,
6... | [
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} ma... | Dronedarone may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Dronedarone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause... |
DB00845 | DB11986 | 1,490 | 484 | [
"DDInter406",
"DDInter648"
] | Clofazimine | Entrectinib | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1490,
24,
484
]
],
[
[
1490,
23,
112
],
[
112,
23,
484
]
],
[
[
1490,
24,
774
],
[
774,
24,
484
]
],
[
[
1490,
63,
1674
],
[
1674,
... | [
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Clofazimine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Clofazimine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Clofazimine may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and De... |
DB00321 | DB01181 | 21 | 1,532 | [
"DDInter78",
"DDInter906"
] | Amitriptyline | Ifosfamide | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
21,
24,
1532
]
],
[
[
21,
6,
3486
],
[
3486,
45,
1532
]
],
[
[
21,
21,
28956
],
[
28956,
60,
1532
]
],
[
[
21,
63,
1648
],
[
1648,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Amitriptyline",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compo... | Amitriptyline (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ifosfamide (Compound)
Amitriptyline (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Alde... |
DB00556 | DB01254 | 1,262 | 1,213 | [
"DDInter1429",
"DDInter484"
] | Perflutren | Dasatinib | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1262,
24,
1213
]
],
[
[
1262,
21,
28882
],
[
28882,
60,
1213
]
],
[
[
1262,
23,
112
],
[
112,
23,
1213
]
],
[
[
1262,
24,
1133
],
[
11... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Perflutren",
"{u} (Compound) causes {v} (Side Effect)",
"Body temperature increased"
],
[
"Body temperature increased",... | Perflutren (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasatinib (Compound)
Perflutren may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clini... |
DB00927 | DB01128 | 1,559 | 918 | [
"DDInter712",
"DDInter204"
] | Famotidine | Bicalutamide | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
1559,
24,
918
]
],
[
[
1559,
24,
129
],
[
129,
40,
918
]
],
[
[
1559,
6,
10215
],
[
10215,
45,
918
]
],
[
[
1559,
21,
28642
],
[
28642... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Famotidine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Bicalutamide (Compound)
Famotidine (Compound) causes Shock (Side Effect) and Sho... |
DB08868 | DB08881 | 1,011 | 868 | [
"DDInter737",
"DDInter1925"
] | Fingolimod | Vemurafenib | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1011,
25,
868
]
],
[
[
1011,
6,
8374
],
[
8374,
45,
868
]
],
[
[
1011,
21,
28847
],
[
28847,
60,
868
]
],
[
[
1011,
63,
479
],
[
479,
... | [
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Fingolimod",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vemura... | Fingolimod (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Fingolimod (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Vemurafenib (Compound)
Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Donepezil a... |
DB01309 | DB06292 | 1,254 | 549 | [
"DDInter933",
"DDInter474"
] | Insulin glulisine | Dapagliflozin | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1254,
24,
549
]
],
[
[
1254,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1254,
62,
1103
],
[
1103,
23,
549
]
],
[
[
1254,
63,
1630
],
[
1630,... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflo... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Insulin glulisine may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor inte... |
DB00461 | DB06754 | 598 | 707 | [
"DDInter1254",
"DDInter471"
] | Nabumetone | Danaparoid | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Major | 2 | [
[
[
598,
25,
707
]
],
[
[
598,
24,
121
],
[
121,
24,
707
]
],
[
[
598,
63,
1560
],
[
1560,
24,
707
]
],
[
[
598,
24,
738
],
[
738,
6... | [
[
[
"Nabumetone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
]
],
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
],
[
"Fenflura... | Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and ... |
DB04844 | DB06663 | 843 | 1,154 | [
"DDInter1778",
"DDInter1398"
] | Tetrabenazine | Pasireotide | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
843,
25,
1154
]
],
[
[
843,
21,
28898
],
[
28898,
60,
1154
]
],
[
[
843,
62,
112
],
[
112,
23,
1154
]
],
[
[
843,
24,
1662
],
[
1662,
... | [
[
[
"Tetrabenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Tetrabenazine",
"{u} (Compound) causes {v} (Side Effect)",
"Constipation"
],
[
"Constipation",
"{u} (Side Effect) is caused... | Tetrabenazine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Pasireotide (Compound)
Tetrabenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when tak... |
DB00630 | DB01082 | 1,485 | 1,448 | [
"DDInter42",
"DDInter1713"
] | Alendronic acid | Streptomycin | Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
1485,
24,
1448
]
],
[
[
1485,
21,
28882
],
[
28882,
60,
1448
]
],
[
[
1485,
24,
361
],
[
361,
24,
1448
]
],
[
[
1485,
1,
1008
],
[
100... | [
[
[
"Alendronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Alendronic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Body temperature increased"
],
[
"Body temperatur... | Alendronic acid (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Streptomycin (Compound)
Alendronic acid may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin may cause a moderate interaction that could e... |
DB00959 | DB06655 | 1,486 | 5 | [
"DDInter1191",
"DDInter1077"
] | Methylprednisolone | Liraglutide | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
1486,
24,
5
]
],
[
[
1486,
63,
743
],
[
743,
23,
5
]
],
[
[
1486,
25,
915
],
[
915,
24,
5
]
],
[
[
1486,
24,
651
],
[
651,
24,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Methylprednisolone may lead to a major life threatening interaction when taken with Atazanavir and Atazan... |
DB00674 | DB06788 | 1,516 | 1,616 | [
"DDInter802",
"DDInter864"
] | Galantamine | Histrelin | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
1516,
24,
1616
]
],
[
[
1516,
24,
112
],
[
112,
23,
1616
]
],
[
[
1516,
24,
1342
],
[
1342,
24,
1616
]
],
[
[
1516,
24,
927
],
[
927,
... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and R... |
DB00581 | DB12245 | 355 | 823 | [
"DDInter1018",
"DDInter1863"
] | Lactulose | Triclabendazole | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
355,
24,
823
]
],
[
[
355,
24,
1612
],
[
1612,
24,
823
]
],
[
[
355,
63,
1010
],
[
1010,
24,
823
]
],
[
[
355,
24,
180
],
[
180,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a moderate interaction that could exacerbate diseases when taken with Triclabendazole
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and M... |
DB00059 | DB04854 | 1,560 | 1,291 | [
"DDInter1404",
"DDInter713"
] | Pegaspargase | Febuxostat | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout. In the following year, the FDA for approved febuxostat for use in the chronic management of hyperuricemia in adult pat... | Moderate | 1 | [
[
[
1560,
24,
1291
]
],
[
[
1560,
24,
372
],
[
372,
24,
1291
]
],
[
[
1560,
24,
384
],
[
384,
63,
1291
]
],
[
[
1560,
25,
1377
],
[
1377,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Febuxostat"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Febuxostat
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and ... |
DB06589 | DB12674 | 1,250 | 975 | [
"DDInter1400",
"DDInter1105"
] | Pazopanib | Lurbinectedin | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
1250,
24,
975
]
],
[
[
1250,
24,
1613
],
[
1613,
24,
975
]
],
[
[
1250,
24,
159
],
[
159,
63,
975
]
],
[
[
1250,
63,
372
],
[
372,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00282 | DB12015 | 641 | 1,033 | [
"DDInter1383",
"DDInter53"
] | Pamidronic acid | Alpelisib | Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid]. Pamidronic acid was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic ... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
641,
24,
1033
]
],
[
[
641,
25,
629
],
[
629,
24,
1033
]
],
[
[
641,
1,
1485
],
[
1485,
24,
1033
]
],
[
[
641,
24,
50
],
[
50,
2... | [
[
[
"Pamidronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Pamidronic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
],
[
"Si... | Pamidronic acid may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Pamidronic acid (Compound) resembles Alendronic acid (Compound) and Alendronic acid may cause a moderate interaction that cou... |
DB01035 | DB01087 | 1,401 | 1,520 | [
"DDInter1524",
"DDInter1520"
] | Procainamide | Primaquine | A derivative of procaine with less CNS action. | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Major | 2 | [
[
[
1401,
25,
1520
]
],
[
[
1401,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
1401,
6,
12523
],
[
12523,
45,
1520
]
],
[
[
1401,
21,
28722
],
[
... | [
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
]
],
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
"Hydroxychloro... | Procainamide may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Procainamide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound)
Procainamide (Compound) caus... |
DB00006 | DB09293 | 942 | 116 | [
"DDInter217",
"DDInter954"
] | Bivalirudin | Iodide I-131 | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
942,
24,
116
]
],
[
[
942,
24,
1004
],
[
1004,
63,
116
]
],
[
[
942,
25,
365
],
[
365,
24,
116
]
],
[
[
942,
25,
235
],
[
235,
6... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl salicylate may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Bivalirudin may lead to a major life threatening interaction when taken with Dalteparin and Dal... |
DB04861 | DB09133 | 1,592 | 1,527 | [
"DDInter1271",
"DDInter965"
] | Nebivolol | Iothalamic acid | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Moderate | 1 | [
[
[
1592,
24,
1527
]
],
[
[
1592,
24,
278
],
[
278,
63,
1527
]
],
[
[
1592,
24,
512
],
[
512,
24,
1527
]
],
[
[
1592,
63,
1648
],
[
1648,
... | [
[
[
"Nebivolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Nebivolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopodic acid"
],
... | Nebivolol may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid and Iopodic acid may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Nebivolol may cause a moderate interaction that could exacerbate diseases when taken with Iopanoic acid ... |
DB00604 | DB12010 | 1,425 | 214 | [
"DDInter385",
"DDInter785"
] | Cisapride | Fostamatinib | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1425,
24,
214
]
],
[
[
1425,
25,
723
],
[
723,
24,
214
]
],
[
[
1425,
64,
322
],
[
322,
24,
214
]
],
[
[
1425,
24,
307
],
[
307,
... | [
[
[
"Cisapride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aprepitant"
],
[
"Aprepitant... | Cisapride may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Cisapride may lead to a major life threatening interaction when taken with Epirubicin and Epirubicin may cause a moderate inte... |
DB00227 | DB06273 | 1,463 | 980 | [
"DDInter1098",
"DDInter1824"
] | Lovastatin | Tocilizumab | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
1463,
24,
980
]
],
[
[
1463,
24,
309
],
[
309,
24,
980
]
],
[
[
1463,
24,
850
],
[
850,
63,
980
]
],
[
[
1463,
35,
467
],
[
467,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
[
... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedoti... |
DB00738 | DB05294 | 485 | 1,069 | [
"DDInter1420",
"DDInter1917"
] | Pentamidine | Vandetanib | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
485,
25,
1069
]
],
[
[
485,
6,
8374
],
[
8374,
45,
1069
]
],
[
[
485,
7,
2065
],
[
2065,
45,
1069
]
],
[
[
485,
21,
29343
],
[
29343,
... | [
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Pentamidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vande... | Pentamidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound)
Pentamidine (Compound) upregulates SRC (Gene) and SRC (Gene) is bound by Vandetanib (Compound)
Pentamidine (Compound) causes Blood creatinine increased (Side Effect) and Blood creatinine increased (Side Effect) is caused by V... |
DB01004 | DB06603 | 563 | 39 | [
"DDInter806",
"DDInter1387"
] | Ganciclovir | Panobinostat | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
563,
24,
39
]
],
[
[
563,
24,
869
],
[
869,
24,
39
]
],
[
[
563,
24,
850
],
[
850,
63,
39
]
],
[
[
563,
63,
482
],
[
482,
24,
... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
],
[... | Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin... |
DB00843 | DB01050 | 479 | 848 | [
"DDInter583",
"DDInter900"
] | Donepezil | Ibuprofen | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Minor | 0 | [
[
[
479,
23,
848
]
],
[
[
479,
6,
6017
],
[
6017,
45,
848
]
],
[
[
479,
21,
28773
],
[
28773,
60,
848
]
],
[
[
479,
63,
752
],
[
752,
... | [
[
[
"Donepezil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ibuprofen"
]
],
[
[
"Donepezil",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Donepezil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ibuprofen (Compound)
Donepezil (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Ibuprofen (Compound)
Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Cimetidi... |
DB06210 | DB08827 | 72 | 990 | [
"DDInter631",
"DDInter1085"
] | Eltrombopag | Lomitapide | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
72,
25,
990
]
],
[
[
72,
24,
1476
],
[
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63,
990
]
],
[
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63,
322
],
[
322,
24,
990
]
],
[
[
72,
24,
1491
],
[
1491,
24,... | [
[
[
"Eltrombopag",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
"Brigatin... | Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Lomitapide
Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epir... |
DB01191 | DB11166 | 1,039 | 18 | [
"DDInter518",
"DDInter104"
] | Dexfenfluramine | Antithrombin Alfa | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Antithrombin Alfa is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations. | Moderate | 1 | [
[
[
1039,
24,
18
]
],
[
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],
[
714,
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[
[
1039,
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[
578,
24... | [
[
[
"Dexfenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Antithrombin Alfa"
]
],
[
[
"Dexfenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
... | Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Antithrombin Alfa
Dexfenfluramine may lead to a major life threatening interaction when taken with Fenfluramine and Fenflu... |
DB11095 | DB15035 | 235 | 503 | [
"DDInter505",
"DDInter1959"
] | Desirudin | Zanubrutinib | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
235,
25,
503
]
],
[
[
235,
63,
222
],
[
222,
24,
503
]
],
[
[
235,
24,
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],
[
738,
24,
503
]
],
[
[
235,
64,
39
],
[
39,
25,
... | [
[
[
"Desirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Desirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutrami... | Desirudin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Desirudin may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Nirap... |
DB00501 | DB08880 | 752 | 1,510 | [
"DDInter380",
"DDInter1771"
] | Cimetidine | Teriflunomide | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Moderate | 1 | [
[
[
752,
24,
1510
]
],
[
[
752,
63,
608
],
[
608,
23,
1510
]
],
[
[
752,
25,
1406
],
[
1406,
63,
1510
]
],
[
[
752,
23,
43
],
[
43,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teriflunomide"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Cimetidine may lead to a major life threatening interaction when taken with Neratinib and Neratinib may cause a m... |
DB06655 | DB06791 | 5 | 1,446 | [
"DDInter1077",
"DDInter1021"
] | Liraglutide | Lanreotide | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Moderate | 1 | [
[
[
5,
24,
1446
]
],
[
[
5,
24,
154
],
[
154,
63,
1446
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],
[
[
5,
63,
1685
],
[
1685,
24,
1446
]
],
[
[
5,
62,
1252
],
[
1252,
24,
... | [
[
[
"Liraglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanreotide"
]
],
[
[
"Liraglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
],
[
... | Liraglutide may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone and Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide
Liraglutide may cause a moderate interaction that could exacerbate diseases when taken with Insulin human and I... |
DB00539 | DB00818 | 11 | 898 | [
"DDInter1837",
"DDInter1538"
] | Toremifene | Propofol | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Moderate | 1 | [
[
[
11,
24,
898
]
],
[
[
11,
6,
7950
],
[
7950,
45,
898
]
],
[
[
11,
21,
30038
],
[
30038,
60,
898
]
],
[
[
11,
23,
112
],
[
112,
62... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propofol"
]
],
[
[
"Toremifene",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Toremifene (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Propofol (Compound)
Toremifene (Compound) causes Thrombosis (Side Effect) and Thrombosis (Side Effect) is caused by Propofol (Compound)
Toremifene may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metro... |
DB01041 | DB14730 | 770 | 1,412 | [
"DDInter1789",
"DDInter264"
] | Thalidomide | Calaspargase pegol | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Major | 2 | [
[
[
770,
25,
1412
]
],
[
[
770,
24,
1439
],
[
1439,
24,
1412
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],
[
[
770,
64,
322
],
[
322,
24,
1412
]
],
[
[
770,
63,
268
],
[
268,
... | [
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
],
[
"... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab and Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Thalidomide may lead to a major life threatening interaction when taken with Epirubicin and Epirubicin ... |
DB00460 | DB01240 | 612 | 885 | [
"DDInter1929",
"DDInter657"
] | Verteporfin | Epoprostenol | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
612,
24,
885
]
],
[
[
612,
63,
1061
],
[
1061,
1,
885
]
],
[
[
612,
21,
28684
],
[
28684,
60,
885
]
],
[
[
612,
24,
1512
],
[
1512,
... | [
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Verteporfin (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Epoprostenol (Compound)
Verteporfin may cause a mo... |
DB00023 | DB12364 | 305 | 1,421 | [
"DDInter127",
"DDInter200"
] | Asparaginase Escherichia coli | Betrixaban | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
305,
24,
1421
]
],
[
[
305,
24,
1151
],
[
1151,
24,
1421
]
],
[
[
305,
25,
990
],
[
990,
24,
1421
]
],
[
[
305,
24,
1056
],
[
1056,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Asparaginase Escherichia coli may lead to a major life threatening interaction when taken with ... |
DB10989 | DB11921 | 496 | 1,019 | [
"DDInter858",
"DDInter492"
] | Hepatitis A Vaccine | Deflazacort | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
496,
24,
1019
]
],
[
[
496,
24,
270
],
[
270,
63,
1019
]
],
[
[
496,
63,
629
],
[
629,
24,
1019
]
],
[
[
496,
24,
1316
],
[
1316,
... | [
[
[
"Hepatitis A Vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Hepatitis A Vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizu... | Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00798 | DB00945 | 1,132 | 1,479 | [
"DDInter815",
"DDInter20"
] | Gentamicin | Acetylsalicylic acid | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
1132,
24,
1479
]
],
[
[
1132,
24,
1338
],
[
1338,
24,
1479
]
],
[
[
1132,
6,
10612
],
[
10612,
45,
1479
]
],
[
[
1132,
21,
28751
],
[
... | [
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid... | Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Gentamicin (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Acetylsalicyli... |
DB00252 | DB00619 | 362 | 1,419 | [
"DDInter1460",
"DDInter909"
] | Phenytoin | Imatinib | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Major | 2 | [
[
[
362,
25,
1419
]
],
[
[
362,
6,
4973
],
[
4973,
45,
1419
]
],
[
[
362,
21,
29084
],
[
29084,
60,
1419
]
],
[
[
362,
24,
222
],
[
222,
... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Imatinib"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Imatinib"
... | Phenytoin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Imatinib (Compound)
Phenytoin (Compound) causes Lymphadenopathy (Side Effect) and Lymphadenopathy (Side Effect) is caused by Imatinib (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and ... |
DB09407 | DB11943 | 853 | 255 | [
"DDInter1114",
"DDInter495"
] | Magnesium chloride | Delafloxacin | Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water. | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
853,
24,
255
]
],
[
[
853,
63,
1283
],
[
1283,
24,
255
]
],
[
[
853,
24,
460
],
[
460,
24,
255
]
],
[
[
853,
24,
1473
],
[
1473,
... | [
[
[
"Magnesium chloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Magnesium chloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium... | Magnesium chloride may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxide and Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Delafloxacin
Magnesium chloride may cause a moderate interaction that could exacerbate diseases when take... |
DB06176 | DB11718 | 1,342 | 927 | [
"DDInter1616",
"DDInter640"
] | Romidepsin | Encorafenib | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1342,
24,
927
]
],
[
[
1342,
62,
112
],
[
112,
23,
927
]
],
[
[
1342,
24,
720
],
[
720,
24,
927
]
],
[
[
1342,
63,
216
],
[
216,
... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Romidepsin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Romidepsin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil and Mi... |
DB00843 | DB09280 | 479 | 1,604 | [
"DDInter583",
"DDInter1101"
] | Donepezil | Lumacaftor | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Moderate | 1 | [
[
[
479,
24,
1604
]
],
[
[
479,
25,
593
],
[
593,
24,
1604
]
],
[
[
479,
62,
522
],
[
522,
24,
1604
]
],
[
[
479,
24,
1194
],
[
1194,
... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
]
],
[
[
"Donepezil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
],
[
"Bupropion",
... | Donepezil may lead to a major life threatening interaction when taken with Bupropion and Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Donepezil may cause a minor interaction that can limit clinical effects when taken with Zafirlukast and Zafirlukast may cause a mo... |
DB01220 | DB12010 | 1,088 | 214 | [
"DDInter1593",
"DDInter785"
] | Rifaximin | Fostamatinib | Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduc... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1088,
24,
214
]
],
[
[
1088,
40,
690
],
[
690,
24,
214
]
],
[
[
1088,
63,
79
],
[
79,
24,
214
]
],
[
[
1088,
24,
1155
],
[
1155,
... | [
[
[
"Rifaximin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Rifaximin",
"{u} (Compound) resembles {v} (Compound)",
"Rifabutin"
],
[
"Rifabutin",
"{u} may cause a moderate ... | Rifaximin (Compound) resembles Rifabutin (Compound) and Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Rifaximin may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exa... |
DB00196 | DB01182 | 600 | 371 | [
"DDInter743",
"DDInter1534"
] | Fluconazole | Propafenone | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
600,
24,
371
]
],
[
[
600,
24,
847
],
[
847,
1,
371
]
],
[
[
600,
25,
704
],
[
704,
1,
371
]
],
[
[
600,
24,
772
],
[
772,
40,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
],
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Propafenone (Compound)
Fluconazole may lead to a major life threatening interaction when taken with Fentanyl and Fentanyl (Compound) resembles Propafenone (Compound)
Fluconazole m... |
DB00619 | DB11796 | 1,419 | 1,612 | [
"DDInter909",
"DDInter786"
] | Imatinib | Fostemsavir | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
1419,
24,
1612
]
],
[
[
1419,
63,
1051
],
[
1051,
23,
1612
]
],
[
[
1419,
24,
98
],
[
98,
23,
1612
]
],
[
[
1419,
25,
1476
],
[
1476,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and... |
DB00278 | DB00461 | 291 | 598 | [
"DDInter117",
"DDInter1254"
] | Argatroban | Nabumetone | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Moderate | 1 | [
[
[
291,
24,
598
]
],
[
[
291,
21,
28810
],
[
28810,
60,
598
]
],
[
[
291,
64,
1271
],
[
1271,
24,
598
]
],
[
[
291,
24,
1512
],
[
1512,
... | [
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabumetone"
]
],
[
[
"Argatroban",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal pain"
],
[
"Gastrointestinal pain",
"{... | Argatroban (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Nabumetone (Compound)
Argatroban may lead to a major life threatening interaction when taken with Alteplase and Alteplase may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00552 | DB05679 | 1,238 | 1,683 | [
"DDInter1425",
"DDInter1907"
] | Pentostatin | Ustekinumab | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
1238,
24,
1683
]
],
[
[
1238,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
1238,
24,
1307
],
[
1307,
24,
1683
]
],
[
[
1238,
63,
589
],
[
589... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphala... |
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