drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00056 | DB14761 | 816 | 242 | [
"DDInter814",
"DDInter1578"
] | Gemtuzumab ozogamicin | Remdesivir | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
816,
24,
242
]
],
[
[
816,
25,
1377
],
[
1377,
24,
242
]
],
[
[
816,
24,
384
],
[
384,
24,
242
]
],
[
[
816,
63,
305
],
[
305,
2... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
],
... | Gemtuzumab ozogamicin may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib a... |
DB00215 | DB00983 | 1,230 | 480 | [
"DDInter388",
"DDInter776"
] | Citalopram | Formoterol | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
1230,
24,
480
]
],
[
[
1230,
25,
1148
],
[
1148,
63,
480
]
],
[
[
1230,
6,
10215
],
[
10215,
45,
480
]
],
[
[
1230,
21,
28963
],
[
289... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isoprenaline"
],
[
"Isoprena... | Citalopram may lead to a major life threatening interaction when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Citalopram (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Formoterol (Compound)
Citalopram (Compound) cause... |
DB00029 | DB11793 | 25 | 738 | [
"DDInter99",
"DDInter1297"
] | Anistreplase | Niraparib | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
25,
24,
738
]
],
[
[
25,
25,
1213
],
[
1213,
24,
738
]
],
[
[
25,
64,
1578
],
[
1578,
24,
738
]
],
[
[
25,
24,
848
],
[
848,
24,... | [
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Anistreplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatini... | Anistreplase may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Anistreplase may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate inter... |
DB00701 | DB06605 | 1,091 | 1,409 | [
"DDInter90",
"DDInter108"
] | Amprenavir | Apixaban | Amprenavir is a protease inhibitor used to treat HIV infection. | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
1091,
24,
1409
]
],
[
[
1091,
6,
3486
],
[
3486,
45,
1409
]
],
[
[
1091,
21,
28787
],
[
28787,
60,
1409
]
],
[
[
1091,
25,
1670
],
[
1... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Amprenavir",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Amprenavir (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Apixaban (Compound)
Amprenavir (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Apixaban (Compound)
Amprenavir may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may cause ... |
DB00775 | DB01009 | 1,226 | 935 | [
"DDInter1818",
"DDInter1009"
] | Tirofiban | Ketoprofen | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
1226,
24,
935
]
],
[
[
1226,
63,
1274
],
[
1274,
24,
935
]
],
[
[
1226,
63,
886
],
[
886,
1,
935
]
],
[
[
1226,
21,
28890
],
[
28890,
... | [
[
[
"Tirofiban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Tirofiban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[
... | Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen
Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketor... |
DB00390 | DB00480 | 1,252 | 1,668 | [
"DDInter554",
"DDInter1035"
] | Digoxin | Lenalidomide | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Moderate | 1 | [
[
[
1252,
24,
1668
]
],
[
[
1252,
24,
770
],
[
770,
40,
1668
]
],
[
[
1252,
7,
7720
],
[
7720,
45,
1668
]
],
[
[
1252,
6,
4973
],
[
4973,
... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenalidomide"
]
],
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
],
[
... | Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide (Compound) resembles Lenalidomide (Compound)
Digoxin (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Lenalidomide (Compound)
Digoxin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is boun... |
DB01050 | DB01088 | 848 | 714 | [
"DDInter900",
"DDInter908"
] | Ibuprofen | Iloprost | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
848,
24,
714
]
],
[
[
848,
6,
2556
],
[
2556,
45,
714
]
],
[
[
848,
63,
1638
],
[
1638,
24,
714
]
],
[
[
848,
64,
1479
],
[
1479,
... | [
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Ibuprofen",
"{u} (Compound) binds {v} (Gene)",
"PLAT"
],
[
"PLAT",
"{u} (Gene) is bound by {v} (Compound)",
"... | Ibuprofen (Compound) binds PLAT (Gene) and PLAT (Gene) is bound by Iloprost (Compound)
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Ibuprofen may lead to a ... |
DB00491 | DB00685 | 127 | 1,299 | [
"DDInter1217",
"DDInter1887"
] | Miglitol | Trovafloxacin | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Moderate | 1 | [
[
[
127,
24,
1299
]
],
[
[
127,
24,
872
],
[
872,
40,
1299
]
],
[
[
127,
63,
1467
],
[
1467,
40,
1299
]
],
[
[
127,
21,
28809
],
[
28809,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trovafloxacin"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
],
[
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin (Compound) resembles Trovafloxacin (Compound... |
DB09293 | DB14006 | 116 | 972 | [
"DDInter954",
"DDInter370"
] | Iodide I-131 | Choline salicylate | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
116,
24,
972
]
],
[
[
116,
63,
553
],
[
553,
24,
972
]
],
[
[
116,
24,
1019
],
[
1019,
24,
972
]
],
[
[
116,
63,
553
],
[
553,
6... | [
[
[
"Iodide I-131",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Iodide I-131",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fondaparinux"
... | Iodide I-131 may cause a moderate interaction that could exacerbate diseases when taken with Fondaparinux and Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Iodide I-131 may cause a moderate interaction that could exacerbate diseases when taken with Defla... |
DB00912 | DB01144 | 473 | 1,326 | [
"DDInter1581",
"DDInter540"
] | Repaglinide | Diclofenamide | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. | Moderate | 1 | [
[
[
473,
24,
1326
]
],
[
[
473,
24,
504
],
[
504,
1,
1326
]
],
[
[
473,
63,
359
],
[
359,
40,
1326
]
],
[
[
473,
24,
674
],
[
674,
4... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenamide"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Diclofenamide (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) r... |
DB00549 | DB09061 | 522 | 1,627 | [
"DDInter1955",
"DDInter284"
] | Zafirlukast | Cannabidiol | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
522,
24,
1627
]
],
[
[
522,
24,
723
],
[
723,
23,
1627
]
],
[
[
522,
24,
351
],
[
351,
62,
1627
]
],
[
[
522,
63,
597
],
[
597,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Riboc... |
DB08899 | DB11837 | 129 | 1,297 | [
"DDInter649",
"DDInter1351"
] | Enzalutamide | Osilodrostat | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
129,
25,
1297
]
],
[
[
129,
25,
1135
],
[
1135,
23,
1297
]
],
[
[
129,
62,
112
],
[
112,
23,
1297
]
],
[
[
129,
25,
466
],
[
466,
... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{... | Enzalutamide may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may ... |
DB00065 | DB00081 | 581 | 273 | [
"DDInter923",
"DDInter1838"
] | Infliximab | Tositumomab | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Major | 2 | [
[
[
581,
25,
273
]
],
[
[
581,
24,
1270
],
[
1270,
63,
273
]
],
[
[
581,
25,
869
],
[
869,
63,
273
]
],
[
[
581,
64,
1184
],
[
1184,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tositumomab"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Tositumomab
Infliximab may lead to a major life threatening interac... |
DB00708 | DB14724 | 1,454 | 48 | [
"DDInter1718",
"DDInter634"
] | Sufentanil | Emapalumab | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority... | Moderate | 1 | [
[
[
1454,
24,
48
]
],
[
[
1454,
1,
704
],
[
704,
24,
48
]
],
[
[
1454,
6,
8374
],
[
8374,
45,
1463
],
[
1463,
24,
48
]
],
[
[
1454,
... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Emapalumab"
]
],
[
[
"Sufentanil",
"{u} (Compound) resembles {v} (Compound)",
"Fentanyl"
],
[
"Fentanyl",
"{u} may cause a moderate in... | Sufentanil (Compound) resembles Fentanyl (Compound) and Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Emapalumab
Sufentanil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lovastatin (Compound) and Lovastatin may cause a moderate interaction that could exacerbate ... |
DB00631 | DB10429 | 372 | 200 | [
"DDInter405",
"DDInter282"
] | Clofarabine | Candida albicans | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
372,
24,
200
]
],
[
[
372,
24,
1683
],
[
1683,
24,
200
]
],
[
[
372,
25,
976
],
[
976,
24,
200
]
],
[
[
372,
63,
168
],
[
168,
2... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Clofarabine may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitini... |
DB00365 | DB09043 | 839 | 135 | [
"DDInter842",
"DDInter36"
] | Grepafloxacin | Albiglutide | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
839,
24,
135
]
],
[
[
839,
25,
126
],
[
126,
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[
1647,
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],
[
[
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467
],
[
467,
2... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
],
[
"Warfa... | Grepafloxacin may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a m... |
DB00827 | DB11248 | 646 | 1,193 | [
"DDInter383",
"DDInter1965"
] | Cinoxacin | Zinc gluconate | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Moderate | 1 | [
[
[
646,
24,
1193
]
],
[
[
646,
24,
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],
[
1096,
23,
1193
]
],
[
[
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167
],
[
167,
23,
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]
],
[
[
646,
23,
1307
],
[
1307,
... | [
[
[
"Cinoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Cinoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
],... | Cinoxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Cinoxacin may lead to a major life threatening interaction when taken with Hydrocortisone and Hyd... |
DB00841 | DB09038 | 532 | 1,450 | [
"DDInter577",
"DDInter636"
] | Dobutamine | Empagliflozin | A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
532,
24,
1450
]
],
[
[
532,
24,
659
],
[
659,
63,
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]
],
[
[
532,
63,
1179
],
[
1179,
24,
1450
]
],
[
[
532,
24,
688
],
[
688,
... | [
[
[
"Dobutamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Dobutamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],
[... | Dobutamine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Dobutamine may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro and... |
DB00776 | DB04845 | 1,335 | 309 | [
"DDInter1360",
"DDInter1001"
] | Oxcarbazepine | Ixabepilone | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
1335,
24,
309
]
],
[
[
1335,
6,
8374
],
[
8374,
45,
309
]
],
[
[
1335,
21,
29269
],
[
29269,
60,
309
]
],
[
[
1335,
40,
307
],
[
307,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Oxcarbazepine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Oxcarbazepine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Oxcarbazepine (Compound) causes Menopausal symptoms (Side Effect) and Menopausal symptoms (Side Effect) is caused by Ixabepilone (Compound)
Oxcarbazepine (Compound) resembles Modafinil (Compound) and Modafinil may cause a ... |
DB00682 | DB06700 | 126 | 643 | [
"DDInter1951",
"DDInter511"
] | Warfarin | Desvenlafaxine | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
126,
24,
643
]
],
[
[
126,
63,
1100
],
[
1100,
1,
643
]
],
[
[
126,
6,
8374
],
[
8374,
45,
643
]
],
[
[
126,
63,
752
],
[
752,
2... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Warfarin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Desvenlafaxine (Compound)
Warfarin may cause a moderate interaction that could exacerb... |
DB00647 | DB00675 | 675 | 888 | [
"DDInter528",
"DDInter1744"
] | Dextropropoxyphene | Tamoxifen | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Major | 2 | [
[
[
675,
25,
888
]
],
[
[
675,
40,
11392
],
[
11392,
40,
888
]
],
[
[
675,
25,
832
],
[
832,
40,
888
]
],
[
[
675,
75,
1594
],
[
1594,
... | [
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tamoxifen"
]
],
[
[
"Dextropropoxyphene",
"{u} (Compound) resembles {v} (Compound)",
"Methadyl Acetate"
],
[
"Methadyl Acetate",
"{u} (Compou... | Dextropropoxyphene (Compound) resembles Methadyl Acetate (Compound) and Methadyl Acetate (Compound) resembles Tamoxifen (Compound)
Dextropropoxyphene may lead to a major life threatening interaction when taken with Tripelennamine and Tripelennamine (Compound) resembles Tamoxifen (Compound)
Dextropropoxyphene (Compound)... |
DB00346 | DB01218 | 472 | 1,493 | [
"DDInter44",
"DDInter852"
] | Alfuzosin | Halofantrine | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
472,
25,
1493
]
],
[
[
472,
6,
8374
],
[
8374,
45,
1493
]
],
[
[
472,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
472,
23,
112
],
[
112,
... | [
[
[
"Alfuzosin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Alfuzosin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Halofan... | Alfuzosin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Halofantrine (Compound)
Alfuzosin (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Alfuzosin may cause a minor interaction that can limit clinical effects when taken w... |
DB00539 | DB00656 | 11 | 827 | [
"DDInter1837",
"DDInter1851"
] | Toremifene | Trazodone | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Major | 2 | [
[
[
11,
25,
827
]
],
[
[
11,
25,
623
],
[
623,
40,
827
]
],
[
[
11,
25,
1630
],
[
1630,
1,
827
]
],
[
[
11,
24,
673
],
[
673,
1,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trazodone"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quetiapine"
],
[
"Quetiapine",
"{u} (C... | Toremifene may lead to a major life threatening interaction when taken with Quetiapine and Quetiapine (Compound) resembles Trazodone (Compound)
Toremifene may lead to a major life threatening interaction when taken with Perphenazine and Perphenazine (Compound) resembles Trazodone (Compound)
Toremifene may cause a moder... |
DB00001 | DB12364 | 1,578 | 1,421 | [
"DDInter1037",
"DDInter200"
] | Lepirudin | Betrixaban | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
1578,
25,
1421
]
],
[
[
1578,
23,
297
],
[
297,
23,
1421
]
],
[
[
1578,
23,
1631
],
[
1631,
62,
1421
]
],
[
[
1578,
24,
992
],
[
992,
... | [
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Lepirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u} ... | Lepirudin may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Betrixaban
Lepirudin may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor... |
DB14409 | DB15091 | 1,129 | 676 | [
"DDInter867",
"DDInter1901"
] | Human adenovirus e serotype 4 strain cl-68578 antigen | Upadacitinib | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Moderate | 1 | [
[
[
1129,
24,
676
]
],
[
[
1129,
63,
1184
],
[
1184,
25,
676
]
],
[
[
1129,
24,
994
],
[
994,
25,
676
]
],
[
[
1129,
63,
1184
],
[
1184,
... | [
[
[
"Human adenovirus e serotype 4 strain cl-68578 antigen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Upadacitinib"
]
],
[
[
"Human adenovirus e serotype 4 strain cl-68578 antigen",
"{u} may cause a moderate interaction... | Human adenovirus e serotype 4 strain cl-68578 antigen may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra may lead to a major life threatening interaction when taken with Upadacitinib
Human adenovirus e serotype 4 strain cl-68578 antigen may cause a moderate interaction... |
DB00312 | DB00762 | 1,023 | 613 | [
"DDInter1423",
"DDInter973"
] | Pentobarbital | Irinotecan | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Moderate | 1 | [
[
[
1023,
24,
613
]
],
[
[
1023,
6,
8374
],
[
8374,
45,
613
]
],
[
[
1023,
18,
7630
],
[
7630,
46,
613
]
],
[
[
1023,
7,
2940
],
[
2940,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
]
],
[
[
"Pentobarbital",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Pentobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Irinotecan (Compound)
Pentobarbital (Compound) downregulates TXLNA (Gene) and TXLNA (Gene) is upregulated by Irinotecan (Compound)
Pentobarbital (Compound) upregulates BUB1B (Gene) and BUB1B (Gene) is downregulated by Irinotecan (Compound)
Pento... |
DB01128 | DB13139 | 918 | 1,032 | [
"DDInter204",
"DDInter1063"
] | Bicalutamide | Levosalbutamol | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
918,
24,
1032
]
],
[
[
918,
24,
617
],
[
617,
23,
1032
]
],
[
[
918,
25,
1618
],
[
1618,
24,
1032
]
],
[
[
918,
24,
124
],
[
124,
... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
],
... | Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Bicalutamide may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib ... |
DB00401 | DB00741 | 84 | 167 | [
"DDInter1298",
"DDInter885"
] | Nisoldipine | Hydrocortisone | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
84,
24,
167
]
],
[
[
84,
24,
1220
],
[
1220,
40,
167
]
],
[
[
84,
24,
870
],
[
870,
1,
167
]
],
[
[
84,
6,
8374
],
[
8374,
45,
... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],... | Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles ... |
DB00431 | DB01364 | 1,503 | 22 | [
"DDInter1072",
"DDInter650"
] | Lindane | Ephedrine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
1503,
24,
22
]
],
[
[
1503,
63,
80
],
[
80,
24,
22
]
],
[
[
1503,
24,
1529
],
[
1529,
63,
22
]
],
[
[
1503,
21,
28762
],
[
28762,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphetamine"
],
[
"A... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfet... |
DB00195 | DB00789 | 726 | 1,431 | [
"DDInter198",
"DDInter796"
] | Betaxolol (ophthalmic) | Gadopentetic acid | Betaxolol is a propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment... | A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706) | Moderate | 1 | [
[
[
726,
24,
1431
]
],
[
[
726,
24,
457
],
[
457,
40,
1431
]
],
[
[
726,
21,
28987
],
[
28987,
60,
1431
]
],
[
[
726,
1,
887
],
[
887,
... | [
[
[
"Betaxolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadopentetic acid"
]
],
[
[
"Betaxolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadodiamide"
],
... | Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Gadopentetic acid
Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Gadodiamide and Gadodiamide (Compound) resembles Gadopentetic acid (Compound)
Betaxolol (Compound) causes Chills (Side Eff... |
DB01285 | DB06688 | 708 | 1,430 | [
"DDInter445",
"DDInter1677"
] | Corticotropin | Sipuleucel-T | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
708,
24,
1430
]
],
[
[
708,
25,
676
],
[
676,
63,
1430
]
],
[
[
708,
24,
1531
],
[
1531,
24,
1430
]
],
[
[
708,
63,
589
],
[
589,
... | [
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Corticotropin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
],
[
"... | Corticotropin may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinu... |
DB00675 | DB01059 | 888 | 956 | [
"DDInter1744",
"DDInter1313"
] | Tamoxifen | Norfloxacin | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Moderate | 1 | [
[
[
888,
24,
956
]
],
[
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888,
24,
872
],
[
872,
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956
]
],
[
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64,
1176
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[
1176,
1,
956
]
],
[
[
888,
24,
1539
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[
1539,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Tamoxifen may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (Compound)
Tamoxif... |
DB01097 | DB16582 | 1,377 | 899 | [
"DDInter1033",
"DDInter1080"
] | Leflunomide | Lisocabtagene maraleucel | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Lisocabtagene maraleucel is a chimeric antigen receptor (CAR) T-cell therapy, similar to [brexucabtagene autoleucel] and [axicabtagene ciloleucel].[A228493,L31588] Lisocabtagene maraleucel is a genetically modified autologous T-cell therapy that targets CD19, the B-lymphocyte surface antigen B4. CAR T-cell therapy has ... | Major | 2 | [
[
[
1377,
25,
899
]
],
[
[
1377,
64,
869
],
[
869,
24,
899
]
],
[
[
1377,
25,
1683
],
[
1683,
24,
899
]
],
[
[
1377,
24,
1430
],
[
1430,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lisocabtagene maraleucel"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Topotecan"
],
[
"Topotecan"... | Leflunomide may lead to a major life threatening interaction when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Lisocabtagene maraleucel
Leflunomide may lead to a major life threatening interaction when taken with Ustekinumab and Ustekinumab may cause... |
DB00358 | DB05812 | 1,010 | 1,374 | [
"DDInter1140",
"DDInter8"
] | Mefloquine | Abiraterone | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
1010,
24,
1374
]
],
[
[
1010,
6,
12523
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[
12523,
45,
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],
[
[
1010,
21,
28809
],
[
28809,
60,
1374
]
],
[
[
1010,
23,
112
],
[
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)"... | Mefloquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Mefloquine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Abiraterone (Compound)
Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and M... |
DB00033 | DB04865 | 342 | 4 | [
"DDInter949",
"DDInter1335"
] | Interferon gamma-1b | Omacetaxine mepesuccinate | Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence ... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
342,
24,
4
]
],
[
[
342,
24,
713
],
[
713,
63,
4
]
],
[
[
342,
63,
305
],
[
305,
24,
4
]
],
[
[
342,
24,
1253
],
[
1253,
24,
... | [
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Interferon gamma-1b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Interferon gamma-1b may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Interferon gamma-1b may cause a moderate interaction that could exacerbate... |
DB01155 | DB11126 | 872 | 900 | [
"DDInter813",
"DDInter276"
] | Gemifloxacin | Calcium gluconate | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Moderate | 1 | [
[
[
872,
24,
900
]
],
[
[
872,
1,
945
],
[
945,
24,
900
]
],
[
[
872,
40,
1176
],
[
1176,
24,
900
]
],
[
[
872,
1,
945
],
[
945,
40,... | [
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Gemifloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Sparfloxacin"
],
[
"Sparfloxacin",
"{u} may ... | Gemifloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Gemifloxacin (Compound) resembles Moxifloxacin (Compound) and Moxifloxacin may cause a moderate interaction that could exacerbate diseases when tak... |
DB00981 | DB08868 | 1,528 | 1,011 | [
"DDInter1462",
"DDInter737"
] | Physostigmine | Fingolimod | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Moderate | 1 | [
[
[
1528,
24,
1011
]
],
[
[
1528,
21,
28653
],
[
28653,
60,
1011
]
],
[
[
1528,
63,
867
],
[
867,
24,
1011
]
],
[
[
1528,
24,
61
],
[
61,
... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
]
],
[
[
"Physostigmine",
"{u} (Compound) causes {v} (Side Effect)",
"Bradycardia"
],
[
"Bradycardia",
"{u} (Side Effec... | Physostigmine (Compound) causes Bradycardia (Side Effect) and Bradycardia (Side Effect) is caused by Fingolimod (Compound)
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Olanzapine and Olanzapine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00539 | DB00757 | 11 | 1,166 | [
"DDInter1837",
"DDInter581"
] | Toremifene | Dolasetron | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
11,
25,
1166
]
],
[
[
11,
6,
8374
],
[
8374,
45,
1166
]
],
[
[
11,
7,
6952
],
[
6952,
46,
1166
]
],
[
[
11,
21,
29027
],
[
29027,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Toremifene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Dolaset... | Toremifene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dolasetron (Compound)
Toremifene (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Dolasetron (Compound)
Toremifene (Compound) causes Ataxia (Side Effect) and Ataxia (Side Effect) is caused by Dolasetron (Compound)
Toremifene... |
DB06817 | DB13749 | 809 | 1,473 | [
"DDInter1563",
"DDInter1116"
] | Raltegravir | Magnesium gluconate | Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval. | Magnesium gluconate is a magnesium salt of gluconate. It demonstrates the highest oral bioavailability of magnesium salts and is used as a mineral supplement. Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to other food products, available as a dietary supplement and used as an... | Moderate | 1 | [
[
[
809,
24,
1473
]
],
[
[
809,
63,
544
],
[
544,
24,
1473
]
],
[
[
809,
24,
853
],
[
853,
24,
1473
]
],
[
[
809,
63,
544
],
[
544,
... | [
[
[
"Raltegravir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium gluconate"
]
],
[
[
"Raltegravir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium sulfat... | Raltegravir may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate and Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium gluconate
Raltegravir may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00927 | DB01166 | 1,559 | 477 | [
"DDInter712",
"DDInter379"
] | Famotidine | Cilostazol | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
1559,
24,
477
]
],
[
[
1559,
6,
10215
],
[
10215,
45,
477
]
],
[
[
1559,
21,
29340
],
[
29340,
60,
477
]
],
[
[
1559,
62,
112
],
[
112... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Famotidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)... | Famotidine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Cilostazol (Compound)
Famotidine (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Cilostazol (Compound)
Famotidine may cause a minor interaction that can limit clinical effects when ... |
DB04868 | DB09074 | 478 | 1,362 | [
"DDInter1293",
"DDInter1327"
] | Nilotinib | Olaparib | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
478,
24,
1362
]
],
[
[
478,
24,
627
],
[
627,
63,
1362
]
],
[
[
478,
63,
896
],
[
896,
24,
1362
]
],
[
[
478,
64,
576
],
[
576,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bictegravir"
],
[
... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir and Bictegravir may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide... |
DB00054 | DB01404 | 1,432 | 757 | [
"DDInter6",
"DDInter820"
] | Abciximab | Ginseng | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Moderate | 1 | [
[
[
1432,
24,
757
]
],
[
[
1432,
64,
25
],
[
25,
24,
757
]
],
[
[
1432,
24,
578
],
[
578,
63,
757
]
],
[
[
1432,
25,
553
],
[
553,
2... | [
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginseng"
]
],
[
[
"Abciximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anistreplase"
],
[
"Anistreplase"... | Abciximab may lead to a major life threatening interaction when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Ginseng
Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a... |
DB00087 | DB14711 | 599 | 779 | [
"DDInter41",
"DDInter1680"
] | Alemtuzumab | Smallpox (Vaccinia) Vaccine, Live | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
599,
25,
779
]
],
[
[
599,
25,
1064
],
[
1064,
25,
779
]
],
[
[
599,
24,
478
],
[
478,
25,
779
]
],
[
[
599,
24,
994
],
[
994,
6... | [
[
[
"Alemtuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Alemtuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"... | Alemtuzumab may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib ma... |
DB00489 | DB13074 | 17 | 877 | [
"DDInter1704",
"DDInter1110"
] | Sotalol | Macimorelin | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
17,
25,
877
]
],
[
[
17,
23,
112
],
[
112,
23,
877
]
],
[
[
17,
24,
85
],
[
85,
24,
877
]
],
[
[
17,
23,
1479
],
[
1479,
24,
... | [
[
[
"Sotalol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Sotalol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazole"... | Sotalol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine ma... |
DB00574 | DB06203 | 121 | 1,002 | [
"DDInter717",
"DDInter51"
] | Fenfluramine | Alogliptin | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
121,
24,
1002
]
],
[
[
121,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
121,
25,
1529
],
[
1529,
24,
1002
]
],
[
[
121,
24,
1674
],
[
1674,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Fenfluramine may lead to a major life threatening interaction when taken with Metamfetamine and Metamfetamine may cause a moderate interaction that could ex... |
DB11793 | DB13007 | 738 | 1,060 | [
"DDInter1297",
"DDInter642"
] | Niraparib | Enfortumab vedotin | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
738,
24,
1060
]
],
[
[
738,
63,
129
],
[
129,
23,
1060
]
],
[
[
738,
24,
913
],
[
913,
23,
1060
]
],
[
[
738,
24,
270
],
[
270,
... | [
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Enfortumab vedotin
Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide a... |
DB00047 | DB00166 | 176 | 333 | [
"DDInter932",
"DDInter1076"
] | Insulin glargine | Lipoic acid | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | A vitamin-like antioxidant. | Minor | 0 | [
[
[
176,
23,
333
]
],
[
[
176,
24,
1645
],
[
1645,
62,
333
]
],
[
[
176,
24,
1645
],
[
1645,
24,
1144
],
[
1144,
62,
333
]
],
[
[
176,
... | [
[
[
"Insulin glargine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lipoic acid"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
]... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a minor interaction that can limit clinical effects when taken with Lipoic acid
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Metformin an... |
DB01067 | DB02546 | 959 | 137 | [
"DDInter826",
"DDInter1947"
] | Glipizide | Vorinostat | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new clas... | Moderate | 1 | [
[
[
959,
24,
137
]
],
[
[
959,
18,
3439
],
[
3439,
46,
137
]
],
[
[
959,
18,
2114
],
[
2114,
57,
137
]
],
[
[
959,
21,
28709
],
[
28709,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vorinostat"
]
],
[
[
"Glipizide",
"{u} (Compound) downregulates {v} (Gene)",
"GRN"
],
[
"GRN",
"{u} (Gene) is upregulated by {v} (Compo... | Glipizide (Compound) downregulates GRN (Gene) and GRN (Gene) is upregulated by Vorinostat (Compound)
Glipizide (Compound) downregulates MIF (Gene) and MIF (Gene) is downregulated by Vorinostat (Compound)
Glipizide (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Vorin... |
DB00047 | DB00621 | 176 | 1,026 | [
"DDInter932",
"DDInter1357"
] | Insulin glargine | Oxandrolone | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | A synthetic hormone with anabolic and androgenic properties. | Moderate | 1 | [
[
[
176,
24,
1026
]
],
[
[
176,
24,
1546
],
[
1546,
1,
1026
]
],
[
[
176,
24,
1019
],
[
1019,
63,
1026
]
],
[
[
176,
24,
1152
],
[
1152,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxandrolone"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestoste... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Oxandrolone (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a ... |
DB00046 | DB01404 | 1,179 | 757 | [
"DDInter940",
"DDInter820"
] | Insulin lispro | Ginseng | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Moderate | 1 | [
[
[
1179,
24,
757
]
],
[
[
1179,
24,
245
],
[
245,
24,
757
]
],
[
[
1179,
24,
1344
],
[
1344,
63,
757
]
],
[
[
1179,
24,
245
],
[
245,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginseng"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Ginseng
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin ... |
DB00719 | DB01080 | 1,219 | 855 | [
"DDInter149",
"DDInter1933"
] | Azatadine | Vigabatrin | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Moderate | 1 | [
[
[
1219,
24,
855
]
],
[
[
1219,
24,
407
],
[
407,
63,
855
]
],
[
[
1219,
24,
401
],
[
401,
24,
855
]
],
[
[
1219,
63,
1594
],
[
1594,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vigabatrin"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
"Op... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Vigabatrin
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may... |
DB00222 | DB00736 | 245 | 660 | [
"DDInter825",
"DDInter676"
] | Glimepiride | Esomeprazole | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Minor | 0 | [
[
[
245,
23,
660
]
],
[
[
245,
21,
28779
],
[
28779,
60,
660
]
],
[
[
245,
24,
972
],
[
972,
62,
660
]
],
[
[
245,
63,
168
],
[
168,
... | [
[
[
"Glimepiride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Esomeprazole"
]
],
[
[
"Glimepiride",
"{u} (Compound) causes {v} (Side Effect)",
"Dry mouth"
],
[
"Dry mouth",
"{u} (Side Effect) is ca... | Glimepiride (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Esomeprazole (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate and Choline salicylate may cause a minor interaction that can limit clinical effects when ... |
DB00619 | DB01242 | 1,419 | 1,237 | [
"DDInter909",
"DDInter410"
] | Imatinib | Clomipramine | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
1419,
24,
1237
]
],
[
[
1419,
25,
684
],
[
684,
1,
1237
]
],
[
[
1419,
24,
1164
],
[
1164,
1,
1237
]
],
[
[
1419,
63,
902
],
[
902,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
"Thioridazi... | Imatinib may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (Compound)
Imatini... |
DB01268 | DB04861 | 1,151 | 1,592 | [
"DDInter1731",
"DDInter1271"
] | Sunitinib | Nebivolol | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
1151,
24,
1592
]
],
[
[
1151,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
1151,
24,
286
],
[
286,
62,
1592
]
],
[
[
1151,
63,
1685
],
[
16... | [
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Sunitinib",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by... | Sunitinib (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken w... |
DB01181 | DB11793 | 1,532 | 738 | [
"DDInter906",
"DDInter1297"
] | Ifosfamide | Niraparib | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
1532,
24,
738
]
],
[
[
1532,
24,
1033
],
[
1033,
63,
738
]
],
[
[
1532,
63,
663
],
[
663,
24,
738
]
],
[
[
1532,
24,
496
],
[
496,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
],
[
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotr... |
DB00802 | DB11730 | 1,322 | 351 | [
"DDInter43",
"DDInter1588"
] | Alfentanil | Ribociclib | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
1322,
24,
351
]
],
[
[
1322,
25,
222
],
[
222,
23,
351
]
],
[
[
1322,
25,
283
],
[
283,
62,
351
]
],
[
[
1322,
63,
597
],
[
597,
... | [
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Alfentanil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutrami... | Alfentanil may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Alfentanil may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a minor interac... |
DB00819 | DB11057 | 471 | 720 | [
"DDInter15",
"DDInter1223"
] | Acetazolamide | Mineral oil | One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its ... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
471,
24,
720
]
],
[
[
471,
63,
175
],
[
175,
24,
720
]
],
[
[
471,
24,
1486
],
[
1486,
24,
720
]
],
[
[
471,
1,
997
],
[
997,
24... | [
[
[
"Acetazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Acetazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
]... | Acetazolamide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Acetazolamide may cause a moderate interaction that could exacerbate diseases when taken with Methylpr... |
DB00630 | DB11248 | 1,485 | 1,193 | [
"DDInter42",
"DDInter1965"
] | Alendronic acid | Zinc gluconate | Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Moderate | 1 | [
[
[
1485,
24,
1193
]
],
[
[
1485,
24,
1596
],
[
1596,
23,
1193
]
],
[
[
1485,
24,
428
],
[
428,
62,
1193
]
],
[
[
1485,
1,
1008
],
[
1008,... | [
[
[
"Alendronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Alendronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
],
... | Alendronic acid may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Alendronic acid may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and ... |
DB00307 | DB00794 | 1,101 | 759 | [
"DDInter202",
"DDInter1521"
] | Bexarotene | Primidone | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Minor | 0 | [
[
[
1101,
23,
759
]
],
[
[
1101,
23,
697
],
[
697,
40,
759
]
],
[
[
1101,
62,
362
],
[
362,
1,
759
]
],
[
[
1101,
6,
6017
],
[
6017,
... | [
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Primidone"
]
],
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Phenobarbital"
],
[
... | Bexarotene may cause a minor interaction that can limit clinical effects when taken with Phenobarbital and Phenobarbital (Compound) resembles Primidone (Compound)
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Phenytoin and Phenytoin (Compound) resembles Primidone (Compound)
Be... |
DB00703 | DB01309 | 997 | 1,254 | [
"DDInter1167",
"DDInter933"
] | Methazolamide | Insulin glulisine | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
997,
24,
1254
]
],
[
[
997,
23,
1669
],
[
1669,
24,
1254
]
],
[
[
997,
62,
1545
],
[
1545,
24,
1254
]
],
[
[
997,
24,
167
],
[
167,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Methazolamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Minocycline"
... | Methazolamide may cause a minor interaction that can limit clinical effects when taken with Minocycline and Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Methazolamide may cause a minor interaction that can limit clinical effects when taken with Oxytetracy... |
DB00572 | DB09481 | 85 | 460 | [
"DDInter136",
"DDInter1113"
] | Atropine | Magnesium carbonate | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
85,
24,
460
]
],
[
[
85,
24,
1592
],
[
1592,
23,
460
]
],
[
[
85,
62,
1252
],
[
1252,
23,
460
]
],
[
[
85,
63,
461
],
[
461,
23,... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
],
... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Nebivolol and Nebivolol may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Atropine may cause a minor interaction that can limit clinical effects when taken with Digoxin and Digoxin ma... |
DB00350 | DB00844 | 1,214 | 314 | [
"DDInter1226",
"DDInter1257"
] | Minoxidil | Nalbuphine | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | Moderate | 1 | [
[
[
1214,
24,
314
]
],
[
[
1214,
24,
828
],
[
828,
40,
314
]
],
[
[
1214,
63,
421
],
[
421,
1,
314
]
],
[
[
1214,
63,
475
],
[
475,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Nalbuphine (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Nalbuphine (Compound... |
DB00655 | DB09038 | 559 | 1,450 | [
"DDInter682",
"DDInter636"
] | Estrone | Empagliflozin | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
559,
24,
1450
]
],
[
[
559,
24,
1486
],
[
1486,
24,
1450
]
],
[
[
559,
63,
1179
],
[
1179,
24,
1450
]
],
[
[
559,
24,
1017
],
[
1017,
... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
],
... | Estrone may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Estrone may cause a moderate interaction that could exacerbate diseases when taken with Insulin ... |
DB01229 | DB11793 | 973 | 738 | [
"DDInter1378",
"DDInter1297"
] | Paclitaxel (protein-bound) | Niraparib | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
973,
24,
738
]
],
[
[
973,
24,
1213
],
[
1213,
24,
738
]
],
[
[
973,
24,
1033
],
[
1033,
63,
738
]
],
[
[
973,
63,
1253
],
[
1253,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Paclitaxel may... |
DB06772 | DB14568 | 310 | 982 | [
"DDInter259",
"DDInter1000"
] | Cabazitaxel | Ivosidenib | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
310,
24,
982
]
],
[
[
310,
63,
112
],
[
112,
23,
982
]
],
[
[
310,
25,
976
],
[
976,
24,
982
]
],
[
[
310,
63,
700
],
[
700,
24,... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Cabazitaxel may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib ma... |
DB00682 | DB06414 | 126 | 655 | [
"DDInter1951",
"DDInter703"
] | Warfarin | Etravirine | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
126,
24,
655
]
],
[
[
126,
6,
6017
],
[
6017,
45,
655
]
],
[
[
126,
24,
1194
],
[
1194,
23,
655
]
],
[
[
126,
62,
168
],
[
168,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Warfarin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Warfarin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Etravirine (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Ranitidine and Ranitidine may cause a minor interaction that can limit clinical effects when taken with Etravirine
Warfarin may cause a min... |
DB01254 | DB09143 | 1,213 | 313 | [
"DDInter484",
"DDInter1701"
] | Dasatinib | Sonidegib | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Moderate | 1 | [
[
[
1213,
24,
313
]
],
[
[
1213,
64,
1194
],
[
1194,
23,
313
]
],
[
[
1213,
25,
101
],
[
101,
23,
313
]
],
[
[
1213,
25,
478
],
[
478,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sonidegib"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ranitidine"
],
[
"Ranitidine",
... | Dasatinib may lead to a major life threatening interaction when taken with Ranitidine and Ranitidine may cause a minor interaction that can limit clinical effects when taken with Sonidegib
Dasatinib may lead to a major life threatening interaction when taken with Dexlansoprazole and Dexlansoprazole may cause a minor in... |
DB01057 | DB01114 | 1,318 | 272 | [
"DDInter615",
"DDInter362"
] | Echothiophate (ophthalmic) | Chlorpheniramine | Ecothiopate is the phosphorothioate obtained by formal condensation of diethyl phosphate with N,N,N-trimethyl-2-sulfanylethanaminium. An irreversible acetylcholinesterase inhibitor, its iodide salt is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inad... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
1318,
24,
272
]
],
[
[
1318,
63,
128
],
[
128,
24,
272
]
],
[
[
1318,
21,
28817
],
[
28817,
60,
272
]
],
[
[
1318,
24,
1429
],
[
1429,... | [
[
[
"Echothiophate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Echothiophate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniram... | Echothiophate may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Echothiophate may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when take... |
DB00738 | DB14509 | 485 | 1,399 | [
"DDInter1420",
"DDInter1081"
] | Pentamidine | Lithium carbonate | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
485,
24,
1399
]
],
[
[
485,
24,
1385
],
[
1385,
24,
1399
]
],
[
[
485,
63,
1010
],
[
1010,
24,
1399
]
],
[
[
485,
23,
112
],
[
112,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide and Semaglutide may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine... |
DB00524 | DB00782 | 811 | 1,123 | [
"DDInter1199",
"DDInter1535"
] | Metolazone | Propantheline | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Minor | 0 | [
[
[
811,
23,
1123
]
],
[
[
811,
21,
28898
],
[
28898,
60,
1123
]
],
[
[
811,
1,
359
],
[
359,
62,
1123
]
],
[
[
811,
40,
1014
],
[
1014,
... | [
[
[
"Metolazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Propantheline"
]
],
[
[
"Metolazone",
"{u} (Compound) causes {v} (Side Effect)",
"Constipation"
],
[
"Constipation",
"{u} (Side Effect) ... | Metolazone (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Propantheline (Compound)
Metolazone (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a minor interaction that can limit clinical effects when taken with Propantheline
Metolazone (Compound) rese... |
DB00182 | DB01362 | 80 | 497 | [
"DDInter84",
"DDInter960"
] | Amphetamine | Iohexol | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
80,
25,
497
]
],
[
[
80,
21,
28681
],
[
28681,
60,
497
]
],
[
[
80,
24,
999
],
[
999,
25,
497
]
],
[
[
80,
24,
22
],
[
22,
64,
... | [
[
[
"Amphetamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Amphetamine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side Effect) is caused... | Amphetamine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may lead to a major life threatening interaction when taken wi... |
DB01276 | DB14276 | 123 | 1,631 | [
"DDInter706",
"DDInter1892"
] | Exenatide | Turmeric | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Moderate | 1 | [
[
[
123,
24,
1631
]
],
[
[
123,
63,
126
],
[
126,
23,
1631
]
],
[
[
123,
63,
473
],
[
473,
24,
1631
]
],
[
[
123,
24,
1254
],
[
1254,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Turmeric"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
"W... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Turmeric
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may... |
DB00927 | DB01072 | 1,559 | 915 | [
"DDInter712",
"DDInter129"
] | Famotidine | Atazanavir | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Major | 2 | [
[
[
1559,
25,
915
]
],
[
[
1559,
24,
833
],
[
833,
1,
915
]
],
[
[
1559,
21,
28642
],
[
28642,
60,
915
]
],
[
[
1559,
24,
1374
],
[
1374,
... | [
[
[
"Famotidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Atazanavir"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lopinavir"
],
[
"Lopinavir",... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Lopinavir and Lopinavir (Compound) resembles Atazanavir (Compound)
Famotidine (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Atazanavir (Compound)
Famotidine may cause a moderate interaction that could... |
DB00978 | DB11057 | 739 | 720 | [
"DDInter1084",
"DDInter1223"
] | Lomefloxacin | Mineral oil | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
739,
24,
720
]
],
[
[
739,
24,
927
],
[
927,
63,
720
]
],
[
[
739,
64,
175
],
[
175,
24,
720
]
],
[
[
739,
24,
1151
],
[
1151,
2... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
... | Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Lomefloxacin may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolo... |
DB01359 | DB12267 | 729 | 1,476 | [
"DDInter1417",
"DDInter233"
] | Penbutolol | Brigatinib | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
729,
24,
1476
]
],
[
[
729,
63,
176
],
[
176,
24,
1476
]
],
[
[
729,
23,
578
],
[
578,
24,
1476
]
],
[
[
729,
24,
1276
],
[
1276,
... | [
[
[
"Penbutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Penbutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glargine"
],
... | Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Penbutolol may cause a minor interaction that can limit clinical effects when taken with Ticagrelor ... |
DB01030 | DB11952 | 869 | 800 | [
"DDInter1835",
"DDInter612"
] | Topotecan | Duvelisib | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
869,
24,
800
]
],
[
[
869,
24,
466
],
[
466,
62,
800
]
],
[
[
869,
24,
310
],
[
310,
24,
800
]
],
[
[
869,
24,
1476
],
[
1476,
6... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Duvelisib
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazi... |
DB00512 | DB12615 | 91 | 1,381 | [
"DDInter1916",
"DDInter1482"
] | Vancomycin | Plazomicin | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from . The structure of plazomicin was established via appending hydroxylaminobutyric acid to at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglyco... | Moderate | 1 | [
[
[
91,
24,
1381
]
],
[
[
91,
24,
416
],
[
416,
24,
1381
]
],
[
[
91,
25,
777
],
[
777,
25,
1381
]
],
[
[
91,
24,
1441
],
[
1441,
25... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Plazomicin"
]
],
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kanamycin"
],
[
... | Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Kanamycin and Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Plazomicin
Vancomycin may lead to a major life threatening interaction when taken with Iopromide and Iopromide may lead to a ... |
DB00612 | DB01075 | 1,121 | 1,376 | [
"DDInter216",
"DDInter569"
] | Bisoprolol | Diphenhydramine | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1121,
24,
1376
]
],
[
[
1121,
24,
401
],
[
401,
24,
1376
]
],
[
[
1121,
6,
12523
],
[
12523,
45,
1376
]
],
[
[
1121,
21,
28921
],
[
28... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Bisoprolol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Diphenhydramine (Compound)
Biso... |
DB11760 | DB13879 | 119 | 1,043 | [
"DDInter1742",
"DDInter824"
] | Talazoparib | Glecaprevir | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Glecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication. In combination with , glecaprevir is a useful therapy for patients who experienced therapeutic failure from other NS3/4A protease inhibitors. It demonstrates a high genetic ba... | Moderate | 1 | [
[
[
119,
24,
1043
]
],
[
[
119,
24,
466
],
[
466,
24,
1043
]
],
[
[
119,
63,
868
],
[
868,
24,
1043
]
],
[
[
119,
63,
467
],
[
467,
... | [
[
[
"Talazoparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glecaprevir"
]
],
[
[
"Talazoparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Talazoparib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Glecaprevir
Talazoparib may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib an... |
DB00816 | DB06663 | 1,674 | 1,154 | [
"DDInter1346",
"DDInter1398"
] | Orciprenaline | Pasireotide | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
1674,
25,
1154
]
],
[
[
1674,
21,
29024
],
[
29024,
60,
1154
]
],
[
[
1674,
24,
1385
],
[
1385,
63,
1154
]
],
[
[
1674,
63,
88
],
[
88... | [
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Orciprenaline",
"{u} (Compound) causes {v} (Side Effect)",
"Hypertension"
],
[
"Hypertension",
"{u} (Side Effect) is caused... | Orciprenaline (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Pasireotide (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide and Semaglutide may cause a moderate interaction that could exacerbate diseases when tak... |
DB00023 | DB00047 | 305 | 176 | [
"DDInter127",
"DDInter932"
] | Asparaginase Escherichia coli | Insulin glargine | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Moderate | 1 | [
[
[
305,
24,
176
]
],
[
[
305,
24,
1324
],
[
1324,
63,
176
]
],
[
[
305,
25,
695
],
[
695,
63,
176
]
],
[
[
305,
24,
1299
],
[
1299,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glargine"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken w... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine
Asparaginase Escherichia coli may lead to a major life threatening interaction when... |
DB00069 | DB00363 | 367 | 695 | [
"DDInter946",
"DDInter419"
] | Interferon alfacon-1 | Clozapine | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Major | 2 | [
[
[
367,
25,
695
]
],
[
[
367,
24,
112
],
[
112,
62,
695
]
],
[
[
367,
24,
1503
],
[
1503,
63,
695
]
],
[
[
367,
24,
1480
],
[
1480,
... | [
[
[
"Interferon alfacon-1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Clozapine
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01044 | DB01073 | 246 | 1,488 | [
"DDInter809",
"DDInter745"
] | Gatifloxacin | Fludarabine | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Minor | 0 | [
[
[
246,
23,
1488
]
],
[
[
246,
62,
372
],
[
372,
1,
1488
]
],
[
[
246,
21,
29106
],
[
29106,
60,
1488
]
],
[
[
246,
1,
1539
],
[
1539,
... | [
[
[
"Gatifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fludarabine"
]
],
[
[
"Gatifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clofarabine"
],
[
... | Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Gatifloxacin (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Fludarabine (Compound)
Gatifloxacin (Compound) resembles Ofloxaci... |
DB01082 | DB01276 | 1,448 | 123 | [
"DDInter1713",
"DDInter706"
] | Streptomycin | Exenatide | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
1448,
24,
123
]
],
[
[
1448,
63,
1338
],
[
1338,
24,
123
]
],
[
[
1448,
24,
445
],
[
445,
63,
123
]
],
[
[
1448,
25,
1329
],
[
1329,
... | [
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid"
]... | Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Givo... |
DB00641 | DB00877 | 467 | 629 | [
"DDInter1675",
"DDInter1678"
] | Simvastatin | Sirolimus | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
467,
24,
629
]
],
[
[
467,
6,
4973
],
[
4973,
45,
629
]
],
[
[
467,
7,
12825
],
[
12825,
46,
629
]
],
[
[
467,
18,
7123
],
[
7123,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Simvastatin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Simvastatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Simvastatin (Compound) upregulates WDR13 (Gene) and WDR13 (Gene) is upregulated by Sirolimus (Compound)
Simvastatin (Compound) downregulates CTGF (Gene) and CTGF (Gene) is upregulated by Sirolimus (Compound)
Simvastatin (Compoun... |
DB00951 | DB12267 | 1,072 | 1,476 | [
"DDInter986",
"DDInter233"
] | Isoniazid | Brigatinib | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
1072,
24,
1476
]
],
[
[
1072,
23,
1135
],
[
1135,
23,
1476
]
],
[
[
1072,
63,
168
],
[
168,
23,
1476
]
],
[
[
1072,
24,
951
],
[
951,
... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Isoniazid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"... | Isoniazid may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may... |
DB01324 | DB09564 | 178 | 1,296 | [
"DDInter1490",
"DDInter930"
] | Polythiazide | Insulin degludec | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
178,
24,
1296
]
],
[
[
178,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
178,
24,
659
],
[
659,
24,
1296
]
],
[
[
178,
1,
674
],
[
674,
... | [
[
[
"Polythiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Polythiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
... | Polythiazide may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Polythiazide may cause a moderate interaction that could exacerbate diseases when taken with Vilantero... |
DB08899 | DB11642 | 129 | 938 | [
"DDInter649",
"DDInter1480"
] | Enzalutamide | Pitolisant | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Major | 2 | [
[
[
129,
25,
938
]
],
[
[
129,
62,
112
],
[
112,
23,
938
]
],
[
[
129,
25,
760
],
[
760,
24,
938
]
],
[
[
129,
24,
28
],
[
28,
24,
... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pitolisant"
]
],
[
[
"Enzalutamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Enzalutamide may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may ... |
DB00673 | DB00696 | 723 | 826 | [
"DDInter112",
"DDInter665"
] | Aprepitant | Ergotamine | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Moderate | 1 | [
[
[
723,
24,
826
]
],
[
[
723,
63,
588
],
[
588,
1,
826
]
],
[
[
723,
63,
1131
],
[
1131,
40,
826
]
],
[
[
723,
24,
628
],
[
628,
1,... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ergotamine"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylergometrine"
],
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Methylergometrine and Methylergometrine (Compound) resembles Ergotamine (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Methysergide and Methysergide (Compound) resembles Ergo... |
DB00063 | DB00208 | 366 | 1,018 | [
"DDInter659",
"DDInter1804"
] | Eptifibatide | Ticlopidine | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Major | 2 | [
[
[
366,
25,
1018
]
],
[
[
366,
25,
1347
],
[
1347,
64,
1018
]
],
[
[
366,
23,
1631
],
[
1631,
62,
1018
]
],
[
[
366,
64,
1271
],
[
1271,
... | [
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ticlopidine"
]
],
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clopidogrel"
],
[
"Clopidogrel",
... | Eptifibatide may lead to a major life threatening interaction when taken with Clopidogrel and Clopidogrel may lead to a major life threatening interaction when taken with Ticlopidine
Eptifibatide may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor intera... |
DB06643 | DB06810 | 1,136 | 397 | [
"DDInter500",
"DDInter1484"
] | Denosumab | Plicamycin | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Moderate | 1 | [
[
[
1136,
24,
397
]
],
[
[
1136,
63,
1184
],
[
1184,
24,
397
]
],
[
[
1136,
24,
384
],
[
384,
63,
397
]
],
[
[
1136,
63,
1172
],
[
1172,
... | [
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Plicamycin"
]
],
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anakinra"
],
[
... | Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Plicamycin
Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib m... |
DB00924 | DB11837 | 1,405 | 1,297 | [
"DDInter454",
"DDInter1351"
] | Cyclobenzaprine | Osilodrostat | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1405,
24,
1297
]
],
[
[
1405,
24,
222
],
[
222,
23,
1297
]
],
[
[
1405,
24,
401
],
[
401,
24,
1297
]
],
[
[
1405,
40,
508
],
[
508,
... | [
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
... | Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Promethaz... |
DB06168 | DB11817 | 1,531 | 1,259 | [
"DDInter281",
"DDInter165"
] | Canakinumab | Baricitinib | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
1531,
25,
1259
]
],
[
[
1531,
23,
1193
],
[
1193,
23,
1259
]
],
[
[
1531,
62,
1461
],
[
1461,
23,
1259
]
],
[
[
1531,
24,
949
],
[
949... | [
[
[
"Canakinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Canakinumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc ... | Canakinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Canakinumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vi... |
DB00220 | DB09038 | 798 | 1,450 | [
"DDInter1276",
"DDInter636"
] | Nelfinavir | Empagliflozin | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
798,
24,
1450
]
],
[
[
798,
24,
659
],
[
659,
63,
1450
]
],
[
[
798,
25,
1486
],
[
1486,
24,
1450
]
],
[
[
798,
63,
1179
],
[
1179,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],
[... | Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Nelfinavir may lead to a major life threatening interaction when taken with Methylprednisolone and Methylpred... |
DB09074 | DB14409 | 1,362 | 1,129 | [
"DDInter1327",
"DDInter867"
] | Olaparib | Human adenovirus e serotype 4 strain cl-68578 antigen | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
1362,
24,
1129
]
],
[
[
1362,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
1362,
63,
1683
],
[
1683,
24,
1129
]
],
[
[
1362,
24,
1456
],
[
14... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Olaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eta... | Olaparib may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Olaparib may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB01115 | DB09074 | 336 | 1,362 | [
"DDInter1291",
"DDInter1327"
] | Nifedipine | Olaparib | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
336,
24,
1362
]
],
[
[
336,
24,
1683
],
[
1683,
24,
1362
]
],
[
[
336,
63,
467
],
[
467,
24,
1362
]
],
[
[
336,
24,
1619
],
[
1619,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
[
... | Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simva... |
DB00773 | DB04845 | 896 | 309 | [
"DDInter702",
"DDInter1001"
] | Etoposide | Ixabepilone | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
896,
24,
309
]
],
[
[
896,
6,
8374
],
[
8374,
45,
309
]
],
[
[
896,
21,
28987
],
[
28987,
60,
309
]
],
[
[
896,
24,
60
],
[
60,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Etoposide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Etoposide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Etoposide (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Ixabepilone (Compound)
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Capecitabine and Capecitab... |
DB00006 | DB00963 | 942 | 1,263 | [
"DDInter217",
"DDInter241"
] | Bivalirudin | Bromfenac | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Moderate | 1 | [
[
[
942,
24,
1263
]
],
[
[
942,
24,
935
],
[
935,
40,
1263
]
],
[
[
942,
24,
1512
],
[
1512,
24,
1263
]
],
[
[
942,
24,
578
],
[
578,
... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
[
... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that coul... |
DB00563 | DB04398 | 663 | 193 | [
"DDInter1174",
"DDInter1015"
] | Methotrexate | Lactic acid | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed) Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste. It is produced by fermentation of a sugar source, such as ... | Minor | 0 | [
[
[
663,
23,
193
]
],
[
[
663,
24,
1620
],
[
1620,
24,
193
]
],
[
[
663,
25,
1479
],
[
1479,
24,
193
]
],
[
[
663,
63,
964
],
[
964,
... | [
[
[
"Methotrexate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lactic acid"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracycline"
],
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline and Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Lactic acid
Methotrexate may lead to a major life threatening interaction when taken with Acetylsalicylic acid and Ac... |
DB00497 | DB01191 | 828 | 1,039 | [
"DDInter1366",
"DDInter518"
] | Oxycodone | Dexfenfluramine | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Moderate | 1 | [
[
[
828,
24,
1039
]
],
[
[
828,
6,
12523
],
[
12523,
45,
1039
]
],
[
[
828,
24,
578
],
[
578,
63,
1039
]
],
[
[
828,
24,
1387
],
[
1387,
... | [
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Oxycodone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound... | Oxycodone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dexfenfluramine (Compound)
Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Oxycodone ... |
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