drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00619 | DB01030 | 1,419 | 869 | [
"DDInter909",
"DDInter1835"
] | Imatinib | Topotecan | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Moderate | 1 | [
[
[
1419,
24,
869
]
],
[
[
1419,
24,
613
],
[
613,
24,
869
]
],
[
[
1419,
6,
17404
],
[
17404,
45,
869
]
],
[
[
1419,
6,
4779
],
[
4779,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
],
[
"... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan and Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Topotecan
Imatinib (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Topotecan (Compound)
Imatinib (Compound) binds ... |
DB00444 | DB09048 | 63 | 555 | [
"DDInter1765",
"DDInter1284"
] | Teniposide | Netupitant | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Moderate | 1 | [
[
[
63,
24,
555
]
],
[
[
63,
24,
283
],
[
283,
62,
555
]
],
[
[
63,
24,
467
],
[
467,
24,
555
]
],
[
[
63,
25,
676
],
[
676,
63,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Netupitant
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvast... |
DB01169 | DB06616 | 57 | 594 | [
"DDInter120",
"DDInter224"
] | Arsenic trioxide | Bosutinib | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
57,
25,
594
]
],
[
[
57,
6,
8374
],
[
8374,
45,
594
]
],
[
[
57,
6,
2374
],
[
2374,
57,
594
]
],
[
[
57,
62,
112
],
[
112,
23,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Arsenic trioxide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Arsenic trioxide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Arsenic trioxide (Compound) binds CCND1 (Gene) and CCND1 (Gene) is downregulated by Bosutinib (Compound)
Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Met... |
DB00006 | DB00460 | 942 | 612 | [
"DDInter217",
"DDInter1929"
] | Bivalirudin | Verteporfin | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Moderate | 1 | [
[
[
942,
24,
612
]
],
[
[
942,
25,
707
],
[
707,
63,
612
]
],
[
[
942,
24,
1512
],
[
1512,
63,
612
]
],
[
[
942,
24,
1061
],
[
1061,
... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verteporfin"
]
],
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
],
[
"Danapar... | Bivalirudin may lead to a major life threatening interaction when taken with Danaparoid and Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Verteporfin
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cau... |
DB06209 | DB08875 | 256 | 1,618 | [
"DDInter1508",
"DDInter262"
] | Prasugrel | Cabozantinib | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
256,
25,
1618
]
],
[
[
256,
62,
188
],
[
188,
24,
1618
]
],
[
[
256,
24,
41
],
[
41,
63,
1618
]
],
[
[
256,
25,
283
],
[
283,
63... | [
[
[
"Prasugrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Prasugrel",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nevirapine"
],
[
"Nevirapine",... | Prasugrel may cause a minor interaction that can limit clinical effects when taken with Nevirapine and Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Prasugrel may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Lev... |
DB00196 | DB00308 | 600 | 347 | [
"DDInter743",
"DDInter901"
] | Fluconazole | Ibutilide | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Major | 2 | [
[
[
600,
25,
347
]
],
[
[
600,
25,
540
],
[
540,
1,
347
]
],
[
[
600,
21,
29024
],
[
29024,
60,
347
]
],
[
[
600,
23,
112
],
[
112,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibutilide"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
],
[
"Dronedarone",
"{u... | Fluconazole may lead to a major life threatening interaction when taken with Dronedarone and Dronedarone (Compound) resembles Ibutilide (Compound)
Fluconazole (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Ibutilide (Compound)
Fluconazole may cause a minor interaction that can ... |
DB00361 | DB11757 | 134 | 960 | [
"DDInter1939",
"DDInter994"
] | Vinorelbine | Istradefylline | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Istradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A<sub>2A</sub> receptors in the basal ganglia. This region of the brain is highly in... | Moderate | 1 | [
[
[
134,
24,
960
]
],
[
[
134,
24,
77
],
[
77,
24,
960
]
],
[
[
134,
63,
600
],
[
600,
24,
960
]
],
[
[
134,
24,
971
],
[
971,
63,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Istradefylline"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
],
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Istradefylline
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and... |
DB00279 | DB00543 | 1,152 | 87 | [
"DDInter1074",
"DDInter82"
] | Liothyronine | Amoxapine | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Moderate | 1 | [
[
[
1152,
24,
87
]
],
[
[
1152,
21,
29118
],
[
29118,
60,
87
]
],
[
[
1152,
24,
959
],
[
959,
63,
87
]
],
[
[
1152,
63,
245
],
[
245,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amoxapine"
]
],
[
[
"Liothyronine",
"{u} (Compound) causes {v} (Side Effect)",
"Tachycardia"
],
[
"Tachycardia",
"{u} (Side Effect) ... | Liothyronine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Amoxapine (Compound)
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Am... |
DB01764 | DB04868 | 805 | 478 | [
"DDInter469",
"DDInter1293"
] | Dalfopristin | Nilotinib | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
805,
24,
478
]
],
[
[
805,
24,
1468
],
[
1468,
63,
478
]
],
[
[
805,
6,
8374
],
[
8374,
45,
478
]
],
[
[
805,
25,
1135
],
[
1135,
... | [
[
[
"Dalfopristin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Dalfopristin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
... | Dalfopristin may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Dalfopristin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Dalfopristin may l... |
DB00468 | DB01268 | 1,424 | 1,151 | [
"DDInter1557",
"DDInter1731"
] | Quinine | Sunitinib | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
1424,
24,
1151
]
],
[
[
1424,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
1424,
21,
29327
],
[
29327,
60,
1151
]
],
[
[
1424,
23,
1247
],
[
1... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Quinine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"S... | Quinine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Quinine (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Sunitinib (Compound)
Quinine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfa... |
DB00872 | DB06616 | 1,080 | 594 | [
"DDInter438",
"DDInter224"
] | Conivaptan | Bosutinib | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
1080,
25,
594
]
],
[
[
1080,
63,
883
],
[
883,
1,
594
]
],
[
[
1080,
6,
8374
],
[
8374,
45,
594
]
],
[
[
1080,
21,
29231
],
[
29231,
... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"Gefitinib",
... | Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Conivaptan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Conivaptan (Compound) causes Cardiac disorder (Side Effect) and Cardia... |
DB00660 | DB01097 | 1,470 | 1,377 | [
"DDInter1163",
"DDInter1033"
] | Metaxalone | Leflunomide | Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
1470,
25,
1377
]
],
[
[
1470,
18,
2049
],
[
2049,
57,
1377
]
],
[
[
1470,
21,
28722
],
[
28722,
60,
1377
]
],
[
[
1470,
24,
1532
],
[
... | [
[
[
"Metaxalone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Metaxalone",
"{u} (Compound) downregulates {v} (Gene)",
"MRPS16"
],
[
"MRPS16",
"{u} (Gene) is downregulated by {v} (Compound)... | Metaxalone (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Leflunomide (Compound)
Metaxalone (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Leflunomide (Compound)
Metaxalone may cause a moderate interaction that could exacerbate diseases when taken with Ifosfam... |
DB00999 | DB06203 | 504 | 1,002 | [
"DDInter883",
"DDInter51"
] | Hydrochlorothiazide | Alogliptin | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
504,
24,
1002
]
],
[
[
504,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
504,
21,
28873
],
[
28873,
60,
1002
]
],
[
[
504,
24,
401
],
[
401,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linaglipt... | Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Hydrochlorothiazide (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Alogliptin (Compound)
Hydrochlorothiazid... |
DB00377 | DB01064 | 1,494 | 1,148 | [
"DDInter1382",
"DDInter987"
] | Palonosetron | Isoprenaline | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
1494,
24,
1148
]
],
[
[
1494,
24,
480
],
[
480,
24,
1148
]
],
[
[
1494,
21,
29282
],
[
29282,
60,
1148
]
],
[
[
1494,
64,
534
],
[
534... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Palonosetron (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Isoprenali... |
DB00476 | DB00563 | 109 | 663 | [
"DDInter608",
"DDInter1174"
] | Duloxetine | Methotrexate | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
109,
24,
663
]
],
[
[
109,
21,
29215
],
[
29215,
60,
663
]
],
[
[
109,
23,
1117
],
[
1117,
62,
663
]
],
[
[
109,
24,
126
],
[
126,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Duloxetine",
"{u} (Compound) causes {v} (Side Effect)",
"Ecchymosis"
],
[
"Ecchymosis",
"{u} (Side Effect) is ... | Duloxetine (Compound) causes Ecchymosis (Side Effect) and Ecchymosis (Side Effect) is caused by Methotrexate (Compound)
Duloxetine may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbonate and Sodium bicarbonate may cause a minor interaction that can limit clinical effects when ta... |
DB00307 | DB01068 | 1,101 | 1,565 | [
"DDInter202",
"DDInter411"
] | Bexarotene | Clonazepam | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Moderate | 1 | [
[
[
1101,
24,
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],
[
[
1101,
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[
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[
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],
[
[
1101,
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1418
],
[
1418,... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonazepam"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midazolam"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam (Compound) resembles Clonazepam (Compound)
Bexarotene may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Clonazepam (Compound)
Bexarotene may caus... |
DB00747 | DB00843 | 1,442 | 479 | [
"DDInter1647",
"DDInter583"
] | Scopolamine | Donepezil | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
1442,
24,
479
]
],
[
[
1442,
21,
28741
],
[
28741,
60,
479
]
],
[
[
1442,
63,
1425
],
[
1425,
24,
479
]
],
[
[
1442,
24,
104
],
[
104,... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Scopolamine",
"{u} (Compound) causes {v} (Side Effect)",
"Agitation"
],
[
"Agitation",
"{u} (Side Effect) is cau... | Scopolamine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Donepezil (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Cisapride and Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Donepezi... |
DB00448 | DB00776 | 1,215 | 1,335 | [
"DDInter1022",
"DDInter1360"
] | Lansoprazole | Oxcarbazepine | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
1215,
24,
1335
]
],
[
[
1215,
24,
1605
],
[
1605,
1,
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]
],
[
[
1215,
63,
902
],
[
902,
40,
1335
]
],
[
[
1215,
6,
8374
],
[
8374,
... | [
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
],
... | Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Oxcarbazepine (Compound)
Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Oxcarbazepine (Comp... |
DB06605 | DB14357 | 1,409 | 944 | [
"DDInter108",
"DDInter347"
] | Apixaban | Chamomile | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
1409,
23,
944
]
],
[
[
1409,
64,
256
],
[
256,
23,
944
]
],
[
[
1409,
25,
498
],
[
498,
23,
944
]
],
[
[
1409,
64,
256
],
[
256,
... | [
[
[
"Apixaban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Apixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel",
... | Apixaban may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Apixaban may lead to a major life threatening interaction when taken with Edoxaban and Edoxaban may cause a minor interaction that can... |
DB00524 | DB01284 | 811 | 1,042 | [
"DDInter1199",
"DDInter1782"
] | Metolazone | Tetracosactide | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
811,
24,
1042
]
],
[
[
811,
24,
455
],
[
455,
23,
1042
]
],
[
[
811,
24,
659
],
[
659,
62,
1042
]
],
[
[
811,
24,
761
],
[
761,
... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vila... |
DB00315 | DB00501 | 767 | 752 | [
"DDInter1969",
"DDInter380"
] | Zolmitriptan | Cimetidine | Zolmitriptan is a member of the triptan class of 5-hydroxytryptamine(5-HT)<sub>1B/1D/(1F)</sub> receptor agonists used to treat acute migraine.[A462, L12978] [Sumatriptan] was the first triptan to be developed, but had poor oral bioavailability and lipophilicity. This led to the development of second-generation triptan... | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Moderate | 1 | [
[
[
767,
24,
752
]
],
[
[
767,
6,
7950
],
[
7950,
45,
752
]
],
[
[
767,
21,
28784
],
[
28784,
60,
752
]
],
[
[
767,
1,
43
],
[
43,
6... | [
[
[
"Zolmitriptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
]
],
[
[
"Zolmitriptan",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compoun... | Zolmitriptan (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Cimetidine (Compound)
Zolmitriptan (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Cimetidine (Compound)
Zolmitriptan (Compound) resembles Melatonin (Compound) and Melatonin may cause a minor inter... |
DB09073 | DB12015 | 951 | 1,033 | [
"DDInter1379",
"DDInter53"
] | Palbociclib | Alpelisib | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
951,
24,
1033
]
],
[
[
951,
63,
154
],
[
154,
24,
1033
]
],
[
[
951,
64,
1510
],
[
1510,
24,
1033
]
],
[
[
951,
24,
985
],
[
985,
... | [
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
],
[
... | Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone and Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Palbociclib may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may... |
DB00945 | DB11943 | 1,479 | 255 | [
"DDInter20",
"DDInter495"
] | Acetylsalicylic acid | Delafloxacin | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
1479,
24,
255
]
],
[
[
1479,
24,
1283
],
[
1283,
24,
255
]
],
[
[
1479,
63,
1512
],
[
1512,
24,
255
]
],
[
[
1479,
25,
848
],
[
848,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magne... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxide and Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Delafloxacin
Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when ... |
DB00008 | DB08886 | 491 | 637 | [
"DDInter1407",
"DDInter126"
] | Peginterferon alfa-2a | Asparaginase Erwinia chrysanthemi | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
491,
24,
637
]
],
[
[
491,
25,
72
],
[
72,
24,
637
]
],
[
[
491,
24,
467
],
[
467,
24,
637
]
],
[
[
491,
24,
1613
],
[
1613,
63,... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Peginterferon alfa-2a may lead to a major life threatening interaction when taken with Eltrombopag and Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when ... |
DB00486 | DB01121 | 1,614 | 94 | [
"DDInter1253",
"DDInter1437"
] | Nabilone | Phenacemide | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures. | Moderate | 1 | [
[
[
1614,
24,
94
]
],
[
[
1614,
24,
551
],
[
551,
1,
94
]
],
[
[
1614,
24,
1364
],
[
1364,
40,
94
]
],
[
[
1614,
24,
662
],
[
662,
2... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenacemide"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Phenacemide (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Guanfacine and Guanfacine (Compound) resembles Phenacemide (Compound)
Na... |
DB04845 | DB12332 | 309 | 1,619 | [
"DDInter1001",
"DDInter1626"
] | Ixabepilone | Rucaparib | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
309,
24,
1619
]
],
[
[
309,
62,
307
],
[
307,
23,
1619
]
],
[
[
309,
63,
112
],
[
112,
23,
1619
]
],
[
[
309,
24,
259
],
[
259,
... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Ixabepilone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Ixabepilone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronid... |
DB00559 | DB09065 | 152 | 760 | [
"DDInter223",
"DDInter424"
] | Bosentan | Cobicistat | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
152,
25,
760
]
],
[
[
152,
62,
1101
],
[
1101,
23,
760
]
],
[
[
152,
63,
1195
],
[
1195,
24,
760
]
],
[
[
152,
24,
723
],
[
723,
... | [
[
[
"Bosentan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Bosentan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",
... | Bosentan may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib may c... |
DB00365 | DB09039 | 839 | 1,670 | [
"DDInter842",
"DDInter629"
] | Grepafloxacin | Eliglustat | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
839,
24,
1670
]
],
[
[
839,
25,
322
],
[
322,
24,
1670
]
],
[
[
839,
24,
594
],
[
594,
24,
1670
]
],
[
[
839,
25,
124
],
[
124,
... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epirubicin"
],
[
"Epir... | Grepafloxacin may lead to a major life threatening interaction when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib may ca... |
DB00594 | DB01285 | 863 | 708 | [
"DDInter68",
"DDInter445"
] | Amiloride | Corticotropin | A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
863,
24,
708
]
],
[
[
863,
24,
123
],
[
123,
24,
708
]
],
[
[
863,
24,
1662
],
[
1662,
63,
708
]
],
[
[
863,
63,
355
],
[
355,
2... | [
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
],
[
... | Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and ... |
DB00704 | DB13873 | 267 | 1,534 | [
"DDInter1263",
"DDInter719"
] | Naltrexone | Fenofibric acid | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B, while increasing high-density lipoprotein cholesterol.[A32038,L128... | Moderate | 1 | [
[
[
267,
24,
1534
]
],
[
[
267,
63,
372
],
[
372,
24,
1534
]
],
[
[
267,
24,
1613
],
[
1613,
24,
1534
]
],
[
[
267,
25,
1377
],
[
1377,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenofibric acid"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Fenofibric acid
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon ... |
DB11581 | DB12147 | 1,456 | 241 | [
"DDInter1926",
"DDInter661"
] | Venetoclax | Erdafitinib | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Moderate | 1 | [
[
[
1456,
24,
241
]
],
[
[
1456,
64,
384
],
[
384,
24,
241
]
],
[
[
1456,
24,
982
],
[
982,
63,
241
]
],
[
[
1456,
63,
26
],
[
26,
2... | [
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erdafitinib"
]
],
[
[
"Venetoclax",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
],
[
"Idelalisi... | Venetoclax may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib and Ivosidenib may cause... |
DB01168 | DB01403 | 1,053 | 9 | [
"DDInter1526",
"DDInter1175"
] | Procarbazine | Methotrimeprazine | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
1053,
24,
9
]
],
[
[
1053,
63,
1178
],
[
1178,
40,
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],
[
[
1053,
64,
1164
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[
1164,
1,
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],
[
[
1053,
63,
401
],
[
401,
24... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Procarbazine may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine (Compound) resembles Methotrimepr... |
DB00687 | DB09020 | 870 | 28 | [
"DDInter747",
"DDInter212"
] | Fludrocortisone | Bisacodyl | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
870,
24,
28
]
],
[
[
870,
6,
1899
],
[
1899,
46,
28
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],
[
[
870,
21,
28778
],
[
28778,
60,
28
]
],
[
[
870,
25,
739
],
[
739,
2... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Fludrocortisone",
"{u} (Compound) binds {v} (Gene)",
"NR3C1"
],
[
"NR3C1",
"{u} (Gene) is upregulated by {v}... | Fludrocortisone (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) is upregulated by Bisacodyl (Compound)
Fludrocortisone (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Bisacodyl (Compound)
Fludrocortisone may lead to a major life threatening interaction when taken with... |
DB00491 | DB00635 | 127 | 1,573 | [
"DDInter1217",
"DDInter1515"
] | Miglitol | Prednisone | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Moderate | 1 | [
[
[
127,
24,
1573
]
],
[
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127,
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175
],
[
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[
[
127,
62,
1103
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[
1103,
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],
[
[
127,
63,
251
],
[
251,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisone (Compound)
Miglitol may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide (Compound) resembles Prednisone (Compound)
... |
DB08865 | DB09115 | 1,593 | 505 | [
"DDInter448",
"DDInter559"
] | Crizotinib | Diiodohydroxyquinoline | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
1593,
24,
505
]
],
[
[
1593,
63,
467
],
[
467,
24,
505
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[
[
1593,
25,
1510
],
[
1510,
24,
505
]
],
[
[
1593,
24,
375
],
[
375,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
... | Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Crizotinib may lead to a major life threatening interaction when taken with Teriflunomide and Teri... |
DB01064 | DB04896 | 1,148 | 901 | [
"DDInter987",
"DDInter1220"
] | Isoprenaline | Milnacipran | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
1148,
24,
901
]
],
[
[
1148,
24,
41
],
[
41,
1,
901
]
],
[
[
1148,
21,
28722
],
[
28722,
60,
901
]
],
[
[
1148,
63,
1636
],
[
1636,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Isoprenaline (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Milnacipran (Compound)
Isoprenaline may cause a moderate ... |
DB00723 | DB01261 | 1,240 | 170 | [
"DDInter1176",
"DDInter1679"
] | Methoxamine | Sitagliptin | An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system. | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1240,
24,
170
]
],
[
[
1240,
24,
52
],
[
52,
62,
170
]
],
[
[
1240,
63,
1179
],
[
1179,
24,
170
]
],
[
[
1240,
24,
1674
],
[
1674,
... | [
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Methoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
],
... | Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when taken with Sitagliptin
Methoxamine may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro and... |
DB00350 | DB04835 | 1,214 | 1,655 | [
"DDInter1226",
"DDInter1125"
] | Minoxidil | Maraviroc | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Moderate | 1 | [
[
[
1214,
24,
1655
]
],
[
[
1214,
7,
19948
],
[
19948,
46,
1655
]
],
[
[
1214,
24,
1061
],
[
1061,
24,
1655
]
],
[
[
1214,
63,
1648
],
[
1... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maraviroc"
]
],
[
[
"Minoxidil",
"{u} (Compound) upregulates {v} (Gene)",
"CNPY3"
],
[
"CNPY3",
"{u} (Gene) is upregulated by {v} (Comp... | Minoxidil (Compound) upregulates CNPY3 (Gene) and CNPY3 (Gene) is upregulated by Maraviroc (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Maraviroc
Minoxidi... |
DB00285 | DB12332 | 1,100 | 1,619 | [
"DDInter1927",
"DDInter1626"
] | Venlafaxine | Rucaparib | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1100,
24,
1619
]
],
[
[
1100,
25,
222
],
[
222,
23,
1619
]
],
[
[
1100,
23,
112
],
[
112,
23,
1619
]
],
[
[
1100,
24,
1662
],
[
1662,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Venlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutram... | Venlafaxine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Venlafaxine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may c... |
DB00703 | DB00731 | 997 | 1,144 | [
"DDInter1167",
"DDInter1269"
] | Methazolamide | Nateglinide | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
997,
24,
1144
]
],
[
[
997,
6,
6017
],
[
6017,
45,
1144
]
],
[
[
997,
21,
28787
],
[
28787,
60,
1144
]
],
[
[
997,
24,
1042
],
[
1042,... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Methazolamide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Comp... | Methazolamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nateglinide (Compound)
Methazolamide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Nateglinide (Compound)
Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Tetrac... |
DB00497 | DB01362 | 828 | 497 | [
"DDInter1366",
"DDInter960"
] | Oxycodone | Iohexol | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
828,
25,
497
]
],
[
[
828,
21,
28681
],
[
28681,
60,
497
]
],
[
[
828,
63,
999
],
[
999,
25,
497
]
],
[
[
828,
24,
1264
],
[
1264,
... | [
[
[
"Oxycodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Oxycodone",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side Effect) is caused by ... | Oxycodone (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may lead to a major life threatening interaction when taken with I... |
DB09020 | DB11901 | 28 | 913 | [
"DDInter212",
"DDInter107"
] | Bisacodyl | Apalutamide | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
28,
24,
913
]
],
[
[
28,
63,
600
],
[
600,
24,
913
]
],
[
[
28,
24,
286
],
[
286,
24,
913
]
],
[
[
28,
24,
823
],
[
823,
63,
... | [
[
[
"Bisacodyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Bisacodyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
... | Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide ... |
DB01172 | DB01250 | 416 | 712 | [
"DDInter1004",
"DDInter1334"
] | Kanamycin | Olsalazine | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Moderate | 1 | [
[
[
416,
24,
712
]
],
[
[
416,
63,
50
],
[
50,
40,
712
]
],
[
[
416,
63,
914
],
[
914,
24,
712
]
],
[
[
416,
7,
7720
],
[
7720,
45,
... | [
[
[
"Kanamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
]
],
[
[
"Kanamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
],
[
... | Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal and Diflunisal may cause a moderate interaction that c... |
DB00910 | DB00976 | 1,041 | 1,056 | [
"DDInter1394",
"DDInter1758"
] | Paricalcitol | Telithromycin | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Moderate | 1 | [
[
[
1041,
24,
1056
]
],
[
[
1041,
6,
8374
],
[
8374,
45,
1056
]
],
[
[
1041,
21,
28681
],
[
28681,
60,
1056
]
],
[
[
1041,
24,
760
],
[
76... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telithromycin"
]
],
[
[
"Paricalcitol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Paricalcitol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Telithromycin (Compound)
Paricalcitol (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Telithromycin (Compound)
Paricalcitol may cause a moderate interaction that could exacerbate diseases when take... |
DB00855 | DB15233 | 213 | 1,650 | [
"DDInter72",
"DDInter142"
] | Aminolevulinic acid | Avapritinib | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
213,
25,
1650
]
],
[
[
213,
64,
1101
],
[
1101,
24,
1650
]
],
[
[
213,
36,
842
],
[
842,
24,
1650
]
],
[
[
213,
25,
918
],
[
918,
... | [
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexaro... | Aminolevulinic acid may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Aminolevulinic acid (Compound) resembles Methyl aminolevulinate (Compound) and Aminolevulinic acid may lead to a majo... |
DB00915 | DB01181 | 1,170 | 1,532 | [
"DDInter60",
"DDInter906"
] | Amantadine | Ifosfamide | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesi... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
1170,
24,
1532
]
],
[
[
1170,
21,
28956
],
[
28956,
60,
1532
]
],
[
[
1170,
24,
401
],
[
401,
24,
1532
]
],
[
[
1170,
63,
13
],
[
13,
... | [
[
[
"Amantadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Amantadine",
"{u} (Compound) causes {v} (Side Effect)",
"Palpitations"
],
[
"Palpitations",
"{u} (Side Effect) i... | Amantadine (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00635 | DB14740 | 1,573 | 771 | [
"DDInter1515",
"DDInter881"
] | Prednisone | Hyaluronidase | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
1573,
23,
771
]
],
[
[
1573,
24,
1438
],
[
1438,
23,
771
]
],
[
[
1573,
40,
167
],
[
167,
23,
771
]
],
[
[
1573,
1,
617
],
[
617,
... | [
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Prednisone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a minor interaction that c... |
DB09038 | DB09082 | 1,450 | 659 | [
"DDInter636",
"DDInter1934"
] | Empagliflozin | Vilanterol | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1450,
24,
659
]
],
[
[
1450,
63,
1220
],
[
1220,
23,
659
]
],
[
[
1450,
24,
1296
],
[
1296,
63,
659
]
],
[
[
1450,
63,
88
],
[
88,
... | [
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],... | Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Insulin deg... |
DB00902 | DB00986 | 104 | 1,192 | [
"DDInter1168",
"DDInter834"
] | Methdilazine | Glycopyrronium | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
104,
24,
1192
]
],
[
[
104,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
104,
63,
262
],
[
262,
24,
1192
]
],
[
[
104,
63,
551
],
[
551,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium a... |
DB01438 | DB08870 | 585 | 850 | [
"DDInter1438",
"DDInter228"
] | Phenazopyridine | Brentuximab vedotin | Phenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management of urinary tract irritation and its associated unpleasant symptoms such as burning and pain during urination. In the USA, this drug was previously marked by Roche but has been discontinued by the FDA. It is still us... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
585,
24,
850
]
],
[
[
585,
63,
267
],
[
267,
24,
850
]
],
[
[
585,
24,
384
],
[
384,
63,
850
]
],
[
[
585,
25,
1510
],
[
1510,
6... | [
[
[
"Phenazopyridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Phenazopyridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexo... | Phenazopyridine may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Phenazopyridine may cause a moderate interaction that could exacerbate diseases when taken with Id... |
DB00531 | DB08865 | 450 | 1,593 | [
"DDInter456",
"DDInter448"
] | Cyclophosphamide | Crizotinib | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
450,
24,
1593
]
],
[
[
450,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
450,
18,
4729
],
[
4729,
57,
1593
]
],
[
[
450,
21,
28771
],
[
28771,... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Cyclophosphamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} ... | Cyclophosphamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Cyclophosphamide (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Crizotinib (Compound)
Cyclophosphamide (Compound) causes Respiratory failure (Side Effect) and Respiratory failure (Side E... |
DB06626 | DB09065 | 263 | 760 | [
"DDInter147",
"DDInter424"
] | Axitinib | Cobicistat | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
263,
25,
760
]
],
[
[
263,
24,
1627
],
[
1627,
23,
760
]
],
[
[
263,
63,
1101
],
[
1101,
23,
760
]
],
[
[
263,
24,
875
],
[
875,
... | [
[
[
"Axitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
[
"Cannabidiol",... | Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene... |
DB00359 | DB09420 | 161 | 1,074 | [
"DDInter1721",
"DDInter953"
] | Sulfadiazine | Iodide I-123 | One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
161,
24,
1074
]
],
[
[
161,
25,
126
],
[
126,
24,
1074
]
],
[
[
161,
1,
50
],
[
50,
24,
1074
]
],
[
[
161,
74,
10
],
[
10,
24,
... | [
[
[
"Sulfadiazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Sulfadiazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
],
[
"Warfar... | Sulfadiazine may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Sulfadiazine (Compound) resembles Sulfasalazine (Compound) and Sulfasalazine may cause a moderate interaction that could exacer... |
DB00741 | DB00963 | 167 | 1,263 | [
"DDInter885",
"DDInter241"
] | Hydrocortisone | Bromfenac | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Moderate | 1 | [
[
[
167,
24,
1263
]
],
[
[
167,
24,
935
],
[
935,
40,
1263
]
],
[
[
167,
63,
831
],
[
831,
40,
1263
]
],
[
[
167,
63,
1512
],
[
1512,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) resembles Bromfenac (... |
DB01324 | DB06335 | 178 | 761 | [
"DDInter1490",
"DDInter1646"
] | Polythiazide | Saxagliptin | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
178,
24,
761
]
],
[
[
178,
21,
28722
],
[
28722,
60,
761
]
],
[
[
178,
1,
1577
],
[
1577,
24,
761
]
],
[
[
178,
63,
104
],
[
104,
... | [
[
[
"Polythiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Polythiazide",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is cause... | Polythiazide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Polythiazide (Compound) resembles Hydroflumethiazide (Compound) and Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin
Polythiazide may cause a mod... |
DB00959 | DB01185 | 1,486 | 155 | [
"DDInter1191",
"DDInter759"
] | Methylprednisolone | Fluoxymesterone | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. | Moderate | 1 | [
[
[
1486,
24,
155
]
],
[
[
1486,
24,
1546
],
[
1546,
40,
155
]
],
[
[
1486,
63,
1561
],
[
1561,
40,
155
]
],
[
[
1486,
1,
175
],
[
175,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymesterone"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyl... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Fluoxymesterone (Compound)
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testosterone (C... |
DB00934 | DB09488 | 413 | 103 | [
"DDInter1124",
"DDInter23"
] | Maprotiline | Acrivastine | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
413,
24,
103
]
],
[
[
413,
63,
85
],
[
85,
24,
103
]
],
[
[
413,
24,
1264
],
[
1264,
24,
103
]
],
[
[
413,
25,
1053
],
[
1053,
2... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
],
[
... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin ma... |
DB00852 | DB01089 | 1,445 | 1,340 | [
"DDInter1545",
"DDInter502"
] | Pseudoephedrine | Deserpidine | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. | Moderate | 1 | [
[
[
1445,
24,
1340
]
],
[
[
1445,
63,
1245
],
[
1245,
40,
1340
]
],
[
[
1445,
24,
1411
],
[
1411,
63,
1340
]
],
[
[
1445,
74,
1466
],
[
14... | [
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deserpidine"
]
],
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Reserpine"
]... | Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Reserpine and Reserpine (Compound) resembles Deserpidine (Compound)
Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction... |
DB00468 | DB00934 | 1,424 | 413 | [
"DDInter1557",
"DDInter1124"
] | Quinine | Maprotiline | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Moderate | 1 | [
[
[
1424,
24,
413
]
],
[
[
1424,
63,
1302
],
[
1302,
40,
413
]
],
[
[
1424,
63,
847
],
[
847,
1,
413
]
],
[
[
1424,
6,
4973
],
[
4973,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
],
[
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Maprotiline (Compound)
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Maprotiline (Compou... |
DB04865 | DB08908 | 4 | 713 | [
"DDInter1335",
"DDInter564"
] | Omacetaxine mepesuccinate | Dimethyl fumarate | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
4,
24,
713
]
],
[
[
4,
63,
1083
],
[
1083,
24,
713
]
],
[
[
4,
24,
594
],
[
594,
24,
713
]
],
[
[
4,
24,
725
],
[
725,
63,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate disea... |
DB00860 | DB01136 | 891 | 772 | [
"DDInter1513",
"DDInter305"
] | Prednisolone | Carvedilol | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
891,
24,
772
]
],
[
[
891,
6,
4973
],
[
4973,
45,
772
]
],
[
[
891,
21,
28997
],
[
28997,
60,
772
]
],
[
[
891,
23,
1283
],
[
1283,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Prednisolone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)... | Prednisolone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Carvedilol (Compound)
Prednisolone (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Carvedilol (Compound)
Prednisolone may cause a minor interaction that can limit clinical effects when taken ... |
DB00615 | DB11703 | 690 | 405 | [
"DDInter1589",
"DDInter9"
] | Rifabutin | Acalabrutinib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
690,
24,
405
]
],
[
[
690,
62,
1101
],
[
1101,
24,
405
]
],
[
[
690,
25,
951
],
[
951,
24,
405
]
],
[
[
690,
25,
1297
],
[
1297,
... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Rifabutin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
... | Rifabutin may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Rifabutin may lead to a major life threatening interaction when taken with Palbociclib and Palbociclib may cause... |
DB00398 | DB00637 | 79 | 1,557 | [
"DDInter1702",
"DDInter128"
] | Sorafenib | Astemizole | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Moderate | 1 | [
[
[
79,
24,
1557
]
],
[
[
79,
25,
1568
],
[
1568,
64,
1557
]
],
[
[
79,
6,
21998
],
[
21998,
45,
1557
]
],
[
[
79,
18,
5833
],
[
5833,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Astemizole"
]
],
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimozide"
],
[
"Pimozide",
... | Sorafenib may lead to a major life threatening interaction when taken with Pimozide and Pimozide may lead to a major life threatening interaction when taken with Astemizole
Sorafenib (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Astemizole (Compound)
Sorafenib (Compound) downregulates A... |
DB00436 | DB00762 | 323 | 613 | [
"DDInter179",
"DDInter973"
] | Bendroflumethiazide | Irinotecan | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Moderate | 1 | [
[
[
323,
24,
613
]
],
[
[
323,
18,
10699
],
[
10699,
57,
613
]
],
[
[
323,
21,
28658
],
[
28658,
60,
613
]
],
[
[
323,
40,
504
],
[
504,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
]
],
[
[
"Bendroflumethiazide",
"{u} (Compound) downregulates {v} (Gene)",
"KIF20A"
],
[
"KIF20A",
"{u} (Gene) is... | Bendroflumethiazide (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is downregulated by Irinotecan (Compound)
Bendroflumethiazide (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Irinotecan (Compound)
Bendroflumethiazide (Compound) resembles Hydrochlorothiazide (Compound) and Hy... |
DB00580 | DB01225 | 311 | 500 | [
"DDInter1910",
"DDInter645"
] | Valdecoxib | Enoxaparin | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Moderate | 1 | [
[
[
311,
24,
500
]
],
[
[
311,
24,
298
],
[
298,
63,
500
]
],
[
[
311,
63,
305
],
[
305,
24,
500
]
],
[
[
311,
24,
1317
],
[
1317,
2... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxaparin"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protein C"
],
[
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Protein C and Protein C may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichi... |
DB01105 | DB06764 | 222 | 1,090 | [
"DDInter1665",
"DDInter1788"
] | Sibutramine | Tetryzoline (ophthalmic) | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Moderate | 1 | [
[
[
222,
24,
1090
]
],
[
[
222,
24,
1032
],
[
1032,
63,
1090
]
],
[
[
222,
25,
901
],
[
901,
24,
1090
]
],
[
[
222,
63,
1290
],
[
1290,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetryzoline"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
],
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol and Levosalbutamol may cause a moderate interaction that could exacerbate diseases when taken with Tetryzolin... |
DB00502 | DB06176 | 1,300 | 1,342 | [
"DDInter853",
"DDInter1616"
] | Haloperidol | Romidepsin | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Major | 2 | [
[
[
1300,
25,
1342
]
],
[
[
1300,
23,
112
],
[
112,
23,
1342
]
],
[
[
1300,
25,
485
],
[
485,
24,
1342
]
],
[
[
1300,
25,
1616
],
[
1616,
... | [
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Romidepsin"
]
],
[
[
"Haloperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Haloperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Haloperidol may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may ... |
DB00902 | DB06335 | 104 | 761 | [
"DDInter1168",
"DDInter1646"
] | Methdilazine | Saxagliptin | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
104,
24,
761
]
],
[
[
104,
63,
1577
],
[
1577,
24,
761
]
],
[
[
104,
24,
178
],
[
178,
24,
761
]
],
[
[
104,
24,
1241
],
[
1241,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide and Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00277 | DB00975 | 1,031 | 1,317 | [
"DDInter1791",
"DDInter573"
] | Theophylline | Dipyridamole | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Moderate | 1 | [
[
[
1031,
24,
1317
]
],
[
[
1031,
6,
16336
],
[
16336,
45,
1317
]
],
[
[
1031,
21,
29296
],
[
29296,
60,
1317
]
],
[
[
1031,
1,
746
],
[
7... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dipyridamole"
]
],
[
[
"Theophylline",
"{u} (Compound) binds {v} (Gene)",
"PDE5A"
],
[
"PDE5A",
"{u} (Gene) is bound by {v} (Compoun... | Theophylline (Compound) binds PDE5A (Gene) and PDE5A (Gene) is bound by Dipyridamole (Compound)
Theophylline (Compound) causes Ventricular extrasystoles (Side Effect) and Ventricular extrasystoles (Side Effect) is caused by Dipyridamole (Compound)
Theophylline (Compound) resembles Dyphylline (Compound) and Dyphylline m... |
DB00619 | DB12500 | 1,419 | 283 | [
"DDInter909",
"DDInter714"
] | Imatinib | Fedratinib | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1419,
24,
283
]
],
[
[
1419,
23,
271
],
[
271,
23,
283
]
],
[
[
1419,
24,
466
],
[
466,
62,
283
]
],
[
[
1419,
24,
351
],
[
351,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Imatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"M... | Imatinib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide... |
DB00424 | DB01100 | 19 | 1,568 | [
"DDInter896",
"DDInter1470"
] | Hyoscyamine | Pimozide | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
19,
24,
1568
]
],
[
[
19,
6,
4304
],
[
4304,
45,
1568
]
],
[
[
19,
18,
4930
],
[
4930,
57,
1568
]
],
[
[
19,
21,
28766
],
[
28766,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Hyoscyamine",
"{u} (Compound) binds {v} (Gene)",
"CHRM2"
],
[
"CHRM2",
"{u} (Gene) is bound by {v} (Compound)",
... | Hyoscyamine (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Pimozide (Compound)
Hyoscyamine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Pimozide (Compound)
Hyoscyamine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Pimozide (Compound)
Hyoscya... |
DB00314 | DB01234 | 894 | 1,220 | [
"DDInter288",
"DDInter513"
] | Capreomycin | Dexamethasone | Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
894,
24,
1220
]
],
[
[
894,
24,
870
],
[
870,
1,
1220
]
],
[
[
894,
24,
175
],
[
175,
40,
1220
]
],
[
[
894,
21,
28882
],
[
28882,
... | [
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]... | Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles D... |
DB00983 | DB08881 | 480 | 868 | [
"DDInter776",
"DDInter1925"
] | Formoterol | Vemurafenib | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
480,
24,
868
]
],
[
[
480,
6,
12523
],
[
12523,
45,
868
]
],
[
[
480,
18,
2097
],
[
2097,
46,
868
]
],
[
[
480,
18,
10375
],
[
10375,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Formoterol",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)"... | Formoterol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Vemurafenib (Compound)
Formoterol (Compound) downregulates ERBB2 (Gene) and ERBB2 (Gene) is upregulated by Vemurafenib (Compound)
Formoterol (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Vemurafenib (Compound)
Formote... |
DB06663 | DB12941 | 1,154 | 466 | [
"DDInter1398",
"DDInter481"
] | Pasireotide | Darolutamide | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Minor | 0 | [
[
[
1154,
23,
466
]
],
[
[
1154,
64,
1622
],
[
1622,
23,
466
]
],
[
[
1154,
63,
336
],
[
336,
23,
466
]
],
[
[
1154,
25,
351
],
[
351,
... | [
[
[
"Pasireotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
]
],
[
[
"Pasireotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voriconazole"
],
[
"Vorico... | Pasireotide may lead to a major life threatening interaction when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nifedipine may ... |
DB01118 | DB09330 | 33 | 985 | [
"DDInter76",
"DDInter1352"
] | Amiodarone | Osimertinib | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
33,
25,
985
]
],
[
[
33,
63,
168
],
[
168,
23,
985
]
],
[
[
33,
24,
1478
],
[
1478,
24,
985
]
],
[
[
33,
63,
134
],
[
134,
24,
... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bortezomi... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacafto... |
DB00651 | DB00816 | 746 | 1,674 | [
"DDInter613",
"DDInter1346"
] | Dyphylline | Orciprenaline | Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
746,
24,
1674
]
],
[
[
746,
5,
11649
],
[
11649,
44,
1674
]
],
[
[
746,
21,
28658
],
[
28658,
60,
1674
]
],
[
[
746,
25,
819
],
[
819,... | [
[
[
"Dyphylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Dyphylline",
"{u} (Compound) treats {v} (Disease)",
"asthma"
],
[
"asthma",
"{u} (Disease) is treated by {v} ... | Dyphylline (Compound) treats asthma (Disease) and asthma (Disease) is treated by Orciprenaline (Compound)
Dyphylline (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Orciprenaline (Compound)
Dyphylline may lead to a major life threatening interaction when taken with Acebutolol and Acebut... |
DB00518 | DB11986 | 510 | 484 | [
"DDInter35",
"DDInter648"
] | Albendazole | Entrectinib | A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38) | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
510,
24,
484
]
],
[
[
510,
24,
1478
],
[
1478,
24,
484
]
],
[
[
510,
24,
159
],
[
159,
63,
484
]
],
[
[
510,
62,
752
],
[
752,
2... | [
[
[
"Albendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Albendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Albendazole may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Albendazole may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and La... |
DB00281 | DB06218 | 608 | 136 | [
"DDInter1066",
"DDInter1014"
] | Lidocaine | Lacosamide | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Lacosamide is an antiepileptic drug used to treat seizures. As a chiral functionalized amino acid, it works by blocking slowly inactivating components of voltage-gated sodium currents. Lacosamide exhibits a stereoselective mode of interaction with sodium channels. Lacosamide was first approved by the European Commissio... | Moderate | 1 | [
[
[
608,
24,
136
]
],
[
[
608,
6,
11001
],
[
11001,
45,
136
]
],
[
[
608,
21,
28681
],
[
28681,
60,
136
]
],
[
[
608,
24,
1154
],
[
1154,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lacosamide"
]
],
[
[
"Lidocaine",
"{u} (Compound) binds {v} (Gene)",
"SCN10A"
],
[
"SCN10A",
"{u} (Gene) is bound by {v} (Compound)",
... | Lidocaine (Compound) binds SCN10A (Gene) and SCN10A (Gene) is bound by Lacosamide (Compound)
Lidocaine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Lacosamide (Compound)
Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Pasireot... |
DB09312 | DB10795 | 967 | 221 | [
"DDInter106",
"DDInter1486"
] | Antithymocyte immunoglobulin (rabbit) | Poliovirus type 1 antigen (formaldehyde inactivated) | Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin i... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
967,
24,
221
]
],
[
[
967,
64,
581
],
[
581,
24,
221
]
],
[
[
967,
63,
599
],
[
599,
24,
221
]
],
[
[
967,
24,
1531
],
[
1531,
2... | [
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may lead to a major life... | Antilymphocyte immunoglobulin (horse) may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Antilymphocyte immunoglobulin (horse) may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate... |
DB00842 | DB01619 | 686 | 830 | [
"DDInter1359",
"DDInter1441"
] | Oxazepam | Phenindamine | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
686,
24,
830
]
],
[
[
686,
63,
1219
],
[
1219,
40,
830
]
],
[
[
686,
1,
11305
],
[
11305,
40,
830
]
],
[
[
686,
63,
13
],
[
13,
... | [
[
[
"Oxazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Oxazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
],
[
... | Oxazepam may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine (Compound) resembles Phenindamine (Compound)
Oxazepam (Compound) resembles Phenindione (Compound) and Phenindione (Compound) resembles Phenindamine (Compound)
Oxazepam may cause a moderate interaction that c... |
DB01036 | DB12500 | 211 | 283 | [
"DDInter1832",
"DDInter714"
] | Tolterodine | Fedratinib | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
211,
24,
283
]
],
[
[
211,
24,
351
],
[
351,
23,
283
]
],
[
[
211,
63,
1419
],
[
1419,
24,
283
]
],
[
[
211,
24,
401
],
[
401,
2... | [
[
[
"Tolterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Tolterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib... |
DB04865 | DB11817 | 4 | 1,259 | [
"DDInter1335",
"DDInter165"
] | Omacetaxine mepesuccinate | Baricitinib | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
4,
25,
1259
]
],
[
[
4,
64,
1274
],
[
1274,
24,
1259
]
],
[
[
4,
24,
949
],
[
949,
24,
1259
]
],
[
[
4,
63,
563
],
[
563,
24,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Flurbiprofen"
],
[... | Omacetaxine mepesuccinate may lead to a major life threatening interaction when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with C... |
DB00619 | DB06636 | 1,419 | 1,623 | [
"DDInter909",
"DDInter980"
] | Imatinib | Isavuconazonium | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
1419,
24,
1623
]
],
[
[
1419,
24,
466
],
[
466,
62,
1623
]
],
[
[
1419,
23,
222
],
[
222,
23,
1623
]
],
[
[
1419,
63,
1601
],
[
1601,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Isavuconazonium
Imatinib may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibu... |
DB00065 | DB00294 | 581 | 1,336 | [
"DDInter923",
"DDInter701"
] | Infliximab | Etonogestrel | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Moderate | 1 | [
[
[
581,
24,
1336
]
],
[
[
581,
24,
566
],
[
566,
1,
1336
]
],
[
[
581,
24,
873
],
[
873,
40,
1336
]
],
[
[
581,
24,
14
],
[
14,
62,... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etonogestrel"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonorgestrel"
],
... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel and Levonorgestrel (Compound) resembles Etonogestrel (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Norgestimate and Norgestimate (Compound) resembles Etonoges... |
DB00994 | DB05351 | 361 | 101 | [
"DDInter1277",
"DDInter519"
] | Neomycin | Dexlansoprazole | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Moderate | 1 | [
[
[
361,
24,
101
]
],
[
[
361,
63,
589
],
[
589,
24,
101
]
],
[
[
361,
24,
1381
],
[
1381,
63,
101
]
],
[
[
361,
62,
1252
],
[
1252,
... | [
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
],
[
... | Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Dexlansoprazole
Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Plazomicin and Plazomi... |
DB00792 | DB00915 | 832 | 1,170 | [
"DDInter1878",
"DDInter60"
] | Tripelennamine | Amantadine | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesi... | Moderate | 1 | [
[
[
832,
24,
1170
]
],
[
[
832,
24,
1532
],
[
1532,
63,
1170
]
],
[
[
832,
24,
1507
],
[
1507,
24,
1170
]
],
[
[
832,
63,
701
],
[
701,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amantadine"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Amantadine
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine a... |
DB00910 | DB09065 | 1,041 | 760 | [
"DDInter1394",
"DDInter424"
] | Paricalcitol | Cobicistat | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1041,
24,
760
]
],
[
[
1041,
24,
34
],
[
34,
24,
760
]
],
[
[
1041,
63,
188
],
[
188,
24,
760
]
],
[
[
1041,
24,
68
],
[
68,
63,... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
],
... | Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Fosamprenavir and Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat
Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Nevirapine ... |
DB00078 | DB08816 | 1,172 | 578 | [
"DDInter898",
"DDInter1802"
] | Ibritumomab tiuxetan | Ticagrelor | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
1172,
24,
578
]
],
[
[
1172,
23,
539
],
[
539,
62,
578
]
],
[
[
1172,
25,
1011
],
[
1011,
62,
578
]
],
[
[
1172,
64,
1578
],
[
1578,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"... | Ibritumomab tiuxetan may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Fingolimod and Fingolimo... |
DB00264 | DB09082 | 88 | 659 | [
"DDInter1200",
"DDInter1934"
] | Metoprolol | Vilanterol | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
88,
24,
659
]
],
[
[
88,
24,
1220
],
[
1220,
23,
659
]
],
[
[
88,
24,
1296
],
[
1296,
63,
659
]
],
[
[
88,
24,
1450
],
[
1450,
2... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec ... |
DB00912 | DB01059 | 473 | 956 | [
"DDInter1581",
"DDInter1313"
] | Repaglinide | Norfloxacin | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Major | 2 | [
[
[
473,
25,
956
]
],
[
[
473,
25,
872
],
[
872,
40,
956
]
],
[
[
473,
64,
1176
],
[
1176,
1,
956
]
],
[
[
473,
25,
1539
],
[
1539,
... | [
[
[
"Repaglinide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Norfloxacin"
]
],
[
[
"Repaglinide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gemifloxacin"
],
[
"Gemifloxacin",
... | Repaglinide may lead to a major life threatening interaction when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Repaglinide may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (Compound)
Repaglinide may le... |
DB00563 | DB11793 | 663 | 738 | [
"DDInter1174",
"DDInter1297"
] | Methotrexate | Niraparib | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
663,
24,
738
]
],
[
[
663,
24,
466
],
[
466,
63,
738
]
],
[
[
663,
63,
1253
],
[
1253,
24,
738
]
],
[
[
663,
24,
496
],
[
496,
2... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Palifermin and... |
DB01142 | DB04946 | 1,264 | 924 | [
"DDInter593",
"DDInter907"
] | Doxepin | Iloperidone | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Major | 2 | [
[
[
1264,
25,
924
]
],
[
[
1264,
63,
1664
],
[
1664,
1,
924
]
],
[
[
1264,
64,
1425
],
[
1425,
25,
924
]
],
[
[
1264,
24,
519
],
[
519,
... | [
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloperidone"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
"Risperidone",
... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Doxepin may lead to a major life threatening interaction when taken with Cisapride and Cisapride may lead to a major life threatening interaction when taken wit... |
DB00209 | DB00363 | 352 | 695 | [
"DDInter1886",
"DDInter419"
] | Trospium | Clozapine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Moderate | 1 | [
[
[
352,
24,
695
]
],
[
[
352,
24,
1178
],
[
1178,
1,
695
]
],
[
[
352,
24,
623
],
[
623,
40,
695
]
],
[
[
352,
24,
1219
],
[
1219,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Clozapine (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Clozapine (Compou... |
DB00835 | DB00980 | 100 | 969 | [
"DDInter245",
"DDInter1564"
] | Brompheniramine | Ramelteon | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Moderate | 1 | [
[
[
100,
24,
969
]
],
[
[
100,
6,
8374
],
[
8374,
45,
969
]
],
[
[
100,
63,
832
],
[
832,
24,
969
]
],
[
[
100,
24,
649
],
[
649,
63... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ramelteon"
]
],
[
[
"Brompheniramine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Co... | Brompheniramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ramelteon (Compound)
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Ramelteon
Br... |
DB00431 | DB00865 | 1,503 | 939 | [
"DDInter1072",
"DDInter187"
] | Lindane | Benzphetamine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | Moderate | 1 | [
[
[
1503,
24,
939
]
],
[
[
1503,
24,
1529
],
[
1529,
1,
939
]
],
[
[
1503,
63,
80
],
[
80,
40,
939
]
],
[
[
1503,
63,
508
],
[
508,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine (Compound) resembles Benzphetamine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Benzphetamine (Co... |
DB00319 | DB00798 | 790 | 1,132 | [
"DDInter1474",
"DDInter815"
] | Piperacillin | Gentamicin | Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Moderate | 1 | [
[
[
790,
24,
1132
]
],
[
[
790,
6,
10612
],
[
10612,
45,
1132
]
],
[
[
790,
21,
28703
],
[
28703,
60,
1132
]
],
[
[
790,
1,
1681
],
[
1681... | [
[
[
"Piperacillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gentamicin"
]
],
[
[
"Piperacillin",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound by {v} (Compo... | Piperacillin (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Gentamicin (Compound)
Piperacillin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Gentamicin (Compound)
Piperacillin (Compound) resembles Mezlocillin (Compound) and Mezlocillin may cause a moderate interaction ... |
DB00366 | DB09061 | 1,594 | 1,627 | [
"DDInter600",
"DDInter284"
] | Doxylamine | Cannabidiol | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
1594,
24,
1627
]
],
[
[
1594,
40,
888
],
[
888,
24,
1627
]
],
[
[
1594,
24,
662
],
[
662,
24,
1627
]
],
[
[
1594,
63,
1648
],
[
1648,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Doxylamine",
"{u} (Compound) resembles {v} (Compound)",
"Tamoxifen"
],
[
"Tamoxifen",
"{u} may cause a moderate... | Doxylamine (Compound) resembles Tamoxifen (Compound) and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that ... |
DB01050 | DB01097 | 848 | 1,377 | [
"DDInter900",
"DDInter1033"
] | Ibuprofen | Leflunomide | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
848,
25,
1377
]
],
[
[
848,
6,
6017
],
[
6017,
45,
1377
]
],
[
[
848,
21,
29062
],
[
29062,
60,
1377
]
],
[
[
848,
24,
242
],
[
242,
... | [
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Ibuprofen",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Leflunom... | Ibuprofen (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Ibuprofen (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Leflunomide (Compound)
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and R... |
DB00398 | DB00581 | 79 | 355 | [
"DDInter1702",
"DDInter1018"
] | Sorafenib | Lactulose | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Moderate | 1 | [
[
[
79,
24,
355
]
],
[
[
79,
21,
28750
],
[
28750,
60,
355
]
],
[
[
79,
24,
361
],
[
361,
62,
355
]
],
[
[
79,
24,
1262
],
[
1262,
2... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
]
],
[
[
"Sorafenib",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal discomfort"
],
[
"Abdominal discomfort",
"{u} (S... | Sorafenib (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Lactulose (Compound)
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin may cause a minor interaction that can limit clinical effects when taken... |
DB01005 | DB01030 | 995 | 869 | [
"DDInter894",
"DDInter1835"
] | Hydroxyurea | Topotecan | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Moderate | 1 | [
[
[
995,
24,
869
]
],
[
[
995,
21,
29067
],
[
29067,
60,
869
]
],
[
[
995,
23,
872
],
[
872,
62,
869
]
],
[
[
995,
62,
1467
],
[
1467,
... | [
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
]
],
[
[
"Hydroxyurea",
"{u} (Compound) causes {v} (Side Effect)",
"Mucosal inflammation"
],
[
"Mucosal inflammation",
"{u... | Hydroxyurea (Compound) causes Mucosal inflammation (Side Effect) and Mucosal inflammation (Side Effect) is caused by Topotecan (Compound)
Hydroxyurea may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin may cause a minor interaction that can limit clinical effects ... |
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