drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00601 | DB06764 | 453 | 1,090 | [
"DDInter1073",
"DDInter1787"
] | Linezolid | Tetryzoline (nasal) | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Major | 2 | [
[
[
453,
37,
1090
]
],
[
[
453,
24,
144
],
[
144,
63,
1090
]
],
[
[
453,
24,
688
],
[
688,
24,
1090
]
],
[
[
453,
25,
222
],
[
222,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Tetryzoline"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could ... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline and Linezolid may lead to a major life threatening interaction when taken with Tetryzoline
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol may cause a... |
DB06723 | DB09263 | 115 | 1,436 | [
"DDInter58",
"DDInter1399"
] | Aluminum hydroxide | Patiromer | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Major | 2 | [
[
[
115,
25,
1436
]
],
[
[
115,
25,
636
],
[
636,
63,
1436
]
],
[
[
115,
62,
1220
],
[
1220,
24,
1436
]
],
[
[
115,
24,
428
],
[
428,
... | [
[
[
"Aluminum hydroxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Patiromer"
]
],
[
[
"Aluminum hydroxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Calcium citrate"
],
[
"Calci... | Aluminum hydroxide may lead to a major life threatening interaction when taken with Calcium citrate and Calcium citrate may cause a moderate interaction that could exacerbate diseases when taken with Patiromer
Aluminum hydroxide may cause a minor interaction that can limit clinical effects when taken with Dexamethasone... |
DB01072 | DB05239 | 915 | 866 | [
"DDInter129",
"DDInter425"
] | Atazanavir | Cobimetinib | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Major | 2 | [
[
[
915,
25,
866
]
],
[
[
915,
25,
214
],
[
214,
63,
866
]
],
[
[
915,
63,
1051
],
[
1051,
24,
866
]
],
[
[
915,
24,
98
],
[
98,
63,... | [
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobimetinib"
]
],
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
],
[
"Fostamatinib",
"... | Atazanavir may lead to a major life threatening interaction when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglut... |
DB00374 | DB00436 | 1,061 | 323 | [
"DDInter1852",
"DDInter179"
] | Treprostinil | Bendroflumethiazide | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Moderate | 1 | [
[
[
1061,
24,
323
]
],
[
[
1061,
24,
1014
],
[
1014,
1,
323
]
],
[
[
1061,
18,
7385
],
[
7385,
57,
323
]
],
[
[
1061,
21,
28766
],
[
28766... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bendroflumethiazide"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazide"
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Bendroflumethiazide (Compound)
Treprostinil (Compound) downregulates MTERF3 (Gene) and MTERF3 (Gene) is downregulated by Bendroflumethiazide (Compound)
Treprostinil (Compound) ... |
DB04861 | DB09082 | 1,592 | 659 | [
"DDInter1271",
"DDInter1934"
] | Nebivolol | Vilanterol | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1592,
24,
659
]
],
[
[
1592,
63,
1220
],
[
1220,
23,
659
]
],
[
[
1592,
24,
1296
],
[
1296,
63,
659
]
],
[
[
1592,
24,
1450
],
[
1450,... | [
[
[
"Nebivolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Nebivolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[
... | Nebivolol may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Nebivolol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec an... |
DB08907 | DB11921 | 1,344 | 1,019 | [
"DDInter280",
"DDInter492"
] | Canagliflozin | Deflazacort | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1344,
24,
1019
]
],
[
[
1344,
63,
1072
],
[
1072,
23,
1019
]
],
[
[
1344,
24,
192
],
[
192,
24,
1019
]
],
[
[
1344,
63,
443
],
[
443,
... | [
[
[
"Canagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Canagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
],
... | Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Esterified estroge... |
DB00741 | DB08895 | 167 | 976 | [
"DDInter885",
"DDInter1825"
] | Hydrocortisone | Tofacitinib | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
167,
25,
976
]
],
[
[
167,
23,
307
],
[
307,
23,
976
]
],
[
[
167,
23,
1193
],
[
1193,
62,
976
]
],
[
[
167,
62,
1461
],
[
1461,
... | [
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Hydrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
"Moda... | Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Z... |
DB00440 | DB00650 | 1,548 | 1,147 | [
"DDInter1874",
"DDInter1041"
] | Trimethoprim | Leucovorin | Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in comb... | Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharma... | Major | 2 | [
[
[
1548,
25,
1147
]
],
[
[
1548,
63,
356
],
[
356,
1,
1147
]
],
[
[
1548,
6,
8569
],
[
8569,
45,
1147
]
],
[
[
1548,
21,
28929
],
[
28929... | [
[
[
"Trimethoprim",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leucovorin"
]
],
[
[
"Trimethoprim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Folic acid"
],
[
"Folic ... | Trimethoprim may cause a moderate interaction that could exacerbate diseases when taken with Folic acid and Folic acid (Compound) resembles Leucovorin (Compound)
Trimethoprim (Compound) binds TYMS (Gene) and TYMS (Gene) is bound by Leucovorin (Compound)
Trimethoprim (Compound) causes Confusional state (Side Effect) and... |
DB06717 | DB08881 | 875 | 868 | [
"DDInter778",
"DDInter1925"
] | Fosaprepitant | Vemurafenib | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
875,
24,
868
]
],
[
[
875,
21,
28847
],
[
28847,
60,
868
]
],
[
[
875,
63,
608
],
[
608,
23,
868
]
],
[
[
875,
25,
1135
],
[
1135,
... | [
[
[
"Fosaprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Fosaprepitant",
"{u} (Compound) causes {v} (Side Effect)",
"Eye disorder"
],
[
"Eye disorder",
"{u} (Side Ef... | Fosaprepitant (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Vemurafenib (Compound)
Fosaprepitant may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken wit... |
DB00550 | DB01097 | 99 | 1,377 | [
"DDInter1541",
"DDInter1033"
] | Propylthiouracil | Leflunomide | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
99,
25,
1377
]
],
[
[
99,
18,
4930
],
[
4930,
57,
1377
]
],
[
[
99,
21,
29275
],
[
29275,
60,
1377
]
],
[
[
99,
24,
242
],
[
242,
... | [
[
[
"Propylthiouracil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Propylthiouracil",
"{u} (Compound) downregulates {v} (Gene)",
"DLD"
],
[
"DLD",
"{u} (Gene) is downregulated by {v} (Com... | Propylthiouracil (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Leflunomide (Compound)
Propylthiouracil (Compound) causes Interstitial lung disease (Side Effect) and Interstitial lung disease (Side Effect) is caused by Leflunomide (Compound)
Propylthiouracil may cause a moderate interaction that... |
DB00323 | DB00719 | 1,062 | 1,219 | [
"DDInter1829",
"DDInter149"
] | Tolcapone | Azatadine | Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
1062,
24,
1219
]
],
[
[
1062,
24,
13
],
[
13,
24,
1219
]
],
[
[
1062,
24,
1376
],
[
1376,
63,
1219
]
],
[
[
1062,
63,
475
],
[
475,
... | [
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
[
... | Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine ... |
DB00722 | DB01261 | 743 | 170 | [
"DDInter1079",
"DDInter1679"
] | Lisinopril | Sitagliptin | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
743,
24,
170
]
],
[
[
743,
6,
4973
],
[
4973,
45,
170
]
],
[
[
743,
18,
3696
],
[
3696,
57,
170
]
],
[
[
743,
21,
28850
],
[
28850,
... | [
[
[
"Lisinopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Lisinopril",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Lisinopril (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sitagliptin (Compound)
Lisinopril (Compound) downregulates ALAS1 (Gene) and ALAS1 (Gene) is downregulated by Sitagliptin (Compound)
Lisinopril (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Sitagliptin (Compound)
L... |
DB00331 | DB00951 | 1,645 | 1,072 | [
"DDInter1164",
"DDInter986"
] | Metformin | Isoniazid | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
1645,
24,
1072
]
],
[
[
1645,
21,
28722
],
[
28722,
60,
1072
]
],
[
[
1645,
24,
1486
],
[
1486,
62,
1072
]
],
[
[
1645,
24,
870
],
[
8... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Metformin",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v}... | Metformin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Isoniazid (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Is... |
DB00401 | DB01110 | 84 | 86 | [
"DDInter1298",
"DDInter1209"
] | Nisoldipine | Miconazole | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
84,
24,
86
]
],
[
[
84,
6,
4973
],
[
4973,
45,
86
]
],
[
[
84,
18,
2976
],
[
2976,
57,
86
]
],
[
[
84,
21,
29081
],
[
29081,
60,... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Nisoldipine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Nisoldipine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Miconazole (Compound)
Nisoldipine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Miconazole (Compound)
Nisoldipine (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Miconazole (Compound)... |
DB00850 | DB09043 | 1,630 | 135 | [
"DDInter1432",
"DDInter36"
] | Perphenazine | Albiglutide | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
1630,
24,
135
]
],
[
[
1630,
63,
1647
],
[
1647,
23,
135
]
],
[
[
1630,
63,
176
],
[
176,
24,
135
]
],
[
[
1630,
35,
820
],
[
820,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and I... |
DB05679 | DB09054 | 1,683 | 384 | [
"DDInter1907",
"DDInter905"
] | Ustekinumab | Idelalisib | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1683,
24,
384
]
],
[
[
1683,
25,
725
],
[
725,
63,
384
]
],
[
[
1683,
63,
328
],
[
328,
24,
384
]
],
[
[
1683,
24,
287
],
[
287,
... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Ustekinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Satralizumab"
],
[
"Satral... | Ustekinumab may lead to a major life threatening interaction when taken with Satralizumab and Satralizumab may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopur... |
DB00710 | DB01377 | 1,199 | 1,283 | [
"DDInter897",
"DDInter1119"
] | Ibandronate | Magnesium oxide | Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatm... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Moderate | 1 | [
[
[
1199,
24,
1283
]
],
[
[
1199,
24,
1479
],
[
1479,
24,
1283
]
],
[
[
1199,
24,
286
],
[
286,
63,
1283
]
],
[
[
1199,
40,
1485
],
[
1485... | [
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Ibandronate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid... | Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxide
Ibandronate may cause a moderate interaction that could exacerbate diseases when taken... |
DB00641 | DB06290 | 467 | 1,449 | [
"DDInter1675",
"DDInter1673"
] | Simvastatin | Simeprevir | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, an... | Moderate | 1 | [
[
[
467,
24,
1449
]
],
[
[
467,
6,
4973
],
[
4973,
45,
1449
]
],
[
[
467,
21,
29093
],
[
29093,
60,
1449
]
],
[
[
467,
24,
119
],
[
119,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simeprevir"
]
],
[
[
"Simvastatin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Simvastatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Simeprevir (Compound)
Simvastatin (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Simeprevir (Compound)
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib and Talazo... |
DB00390 | DB00448 | 1,252 | 1,215 | [
"DDInter554",
"DDInter1022"
] | Digoxin | Lansoprazole | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Moderate | 1 | [
[
[
1252,
24,
1215
]
],
[
[
1252,
24,
379
],
[
379,
1,
1215
]
],
[
[
1252,
63,
837
],
[
837,
1,
1215
]
],
[
[
1252,
6,
8374
],
[
8374,
... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
]
],
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
],
[
... | Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole (Compound) resembles Lansoprazole (Compound)
Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Pantoprazole and Pantoprazole (Compound) resembles Lansoprazole (Compou... |
DB01001 | DB01069 | 688 | 401 | [
"DDInter1632",
"DDInter1533"
] | Salbutamol | Promethazine | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
688,
24,
401
]
],
[
[
688,
24,
1264
],
[
1264,
63,
401
]
],
[
[
688,
63,
939
],
[
939,
24,
401
]
],
[
[
688,
21,
28709
],
[
28709,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphe... |
DB00559 | DB12332 | 152 | 1,619 | [
"DDInter223",
"DDInter1626"
] | Bosentan | Rucaparib | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
152,
24,
1619
]
],
[
[
152,
24,
222
],
[
222,
23,
1619
]
],
[
[
152,
24,
309
],
[
309,
24,
1619
]
],
[
[
152,
25,
1019
],
[
1019,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilon... |
DB00073 | DB11767 | 1,394 | 1,583 | [
"DDInter1608",
"DDInter1643"
] | Rituximab | Sarilumab | Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Major | 2 | [
[
[
1394,
25,
1583
]
],
[
[
1394,
23,
1461
],
[
1461,
23,
1583
]
],
[
[
1394,
24,
1186
],
[
1186,
24,
1583
]
],
[
[
1394,
24,
287
],
[
287... | [
[
[
"Rituximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sarilumab"
]
],
[
[
"Rituximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Rituximab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Sarilumab
Rituximab may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 dichloride and R... |
DB00222 | DB00812 | 245 | 998 | [
"DDInter825",
"DDInter1451"
] | Glimepiride | Phenylbutazone | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Moderate | 1 | [
[
[
245,
24,
998
]
],
[
[
245,
24,
804
],
[
804,
40,
998
]
],
[
[
245,
24,
362
],
[
362,
1,
998
]
],
[
[
245,
6,
6017
],
[
6017,
45,... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfinpyrazone"
]... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone and Sulfinpyrazone (Compound) resembles Phenylbutazone (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenylbuta... |
DB00108 | DB00305 | 1,066 | 377 | [
"DDInter1268",
"DDInter1232"
] | Natalizumab | Mitomycin | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Major | 2 | [
[
[
1066,
25,
377
]
],
[
[
1066,
25,
450
],
[
450,
63,
377
]
],
[
[
1066,
25,
552
],
[
552,
24,
377
]
],
[
[
1066,
24,
987
],
[
987,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mitomycin"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cyclophosphamide"
],
[
"Cyclophosphamide",... | Natalizumab may lead to a major life threatening interaction when taken with Cyclophosphamide and Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin
Natalizumab may lead to a major life threatening interaction when taken with Carmustine and Carmustine may cause a ... |
DB00065 | DB00970 | 581 | 0 | [
"DDInter923",
"DDInter466"
] | Infliximab | Dactinomycin | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Major | 2 | [
[
[
581,
25,
0
]
],
[
[
581,
25,
259
],
[
259,
63,
0
]
],
[
[
581,
24,
496
],
[
496,
63,
0
]
],
[
[
581,
64,
1184
],
[
1184,
24,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dactinomycin"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilonacept"
],
[
"Rilonacept",
"{u}... | Infliximab may lead to a major life threatening interaction when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Dactinomycin
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis ... |
DB11569 | DB12674 | 1,093 | 975 | [
"DDInter1003",
"DDInter1105"
] | Ixekizumab | Lurbinectedin | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
1093,
24,
975
]
],
[
[
1093,
63,
147
],
[
147,
24,
975
]
],
[
[
1093,
24,
270
],
[
270,
24,
975
]
],
[
[
1093,
25,
1259
],
[
1259,
... | [
[
[
"Ixekizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Ixekizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
],
... | Ixekizumab may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Ixekizumab may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and ... |
DB00633 | DB00692 | 614 | 274 | [
"DDInter520",
"DDInter1448"
] | Dexmedetomidine | Phentolamine | An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine. | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Moderate | 1 | [
[
[
614,
24,
274
]
],
[
[
614,
6,
5372
],
[
5372,
45,
274
]
],
[
[
614,
21,
29118
],
[
29118,
60,
274
]
],
[
[
614,
63,
530
],
[
530,
... | [
[
[
"Dexmedetomidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]
],
[
[
"Dexmedetomidine",
"{u} (Compound) binds {v} (Gene)",
"ADRA2A"
],
[
"ADRA2A",
"{u} (Gene) is bound by {v} ... | Dexmedetomidine (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) is bound by Phentolamine (Compound)
Dexmedetomidine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Phentolamine (Compound)
Dexmedetomidine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00543 | DB00682 | 87 | 126 | [
"DDInter82",
"DDInter1951"
] | Amoxapine | Warfarin | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
87,
24,
126
]
],
[
[
87,
24,
1376
],
[
1376,
40,
126
]
],
[
[
87,
6,
6943
],
[
6943,
45,
126
]
],
[
[
87,
25,
1053
],
[
1053,
62... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[
... | Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Warfarin (Compound)
Amoxapine (Compound) binds ORM1 (Gene) and ORM1 (Gene) is bound by Warfarin (Compound)
Amoxapine may lead to a major life threatening interaction when ta... |
DB00444 | DB05773 | 63 | 1,047 | [
"DDInter1765",
"DDInter1848"
] | Teniposide | Trastuzumab emtansine | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
63,
24,
1047
]
],
[
[
63,
25,
375
],
[
375,
63,
1047
]
],
[
[
63,
24,
381
],
[
381,
63,
1047
]
],
[
[
63,
24,
1112
],
[
1112,
24... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Teniposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
],
... | Teniposide may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Sodium au... |
DB00813 | DB01142 | 704 | 1,264 | [
"DDInter722",
"DDInter593"
] | Fentanyl | Doxepin | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Major | 2 | [
[
[
704,
25,
1264
]
],
[
[
704,
24,
401
],
[
401,
24,
1264
]
],
[
[
704,
63,
832
],
[
832,
24,
1264
]
],
[
[
704,
24,
649
],
[
649,
... | [
[
[
"Fentanyl",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
]
],
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
"Promethazine",
... | Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripe... |
DB00635 | DB08822 | 1,573 | 911 | [
"DDInter1515",
"DDInter156"
] | Prednisone | Azilsartan medoxomil | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Moderate | 1 | [
[
[
1573,
24,
911
]
],
[
[
1573,
63,
217
],
[
217,
1,
911
]
],
[
[
1573,
24,
240
],
[
240,
1,
911
]
],
[
[
1573,
21,
28880
],
[
28880,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azilsartan medoxomil"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olmesartan"
]... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and Olmesartan (Compound) resembles Azilsartan medoxomil (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) resembles Azilsartan medox... |
DB00046 | DB01232 | 1,179 | 1,327 | [
"DDInter940",
"DDInter1640"
] | Insulin lispro | Saquinavir | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Moderate | 1 | [
[
[
1179,
24,
1327
]
],
[
[
1179,
24,
798
],
[
798,
40,
1327
]
],
[
[
1179,
24,
222
],
[
222,
23,
1327
]
],
[
[
1179,
24,
52
],
[
52,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction tha... |
DB00738 | DB00983 | 485 | 480 | [
"DDInter1420",
"DDInter776"
] | Pentamidine | Formoterol | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
485,
24,
480
]
],
[
[
485,
24,
1148
],
[
1148,
63,
480
]
],
[
[
485,
6,
10215
],
[
10215,
45,
480
]
],
[
[
485,
21,
28963
],
[
28963,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Pentamidine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Formoterol (Compound)
Pentamidin... |
DB00950 | DB12141 | 1,413 | 971 | [
"DDInter732",
"DDInter817"
] | Fexofenadine | Gilteritinib | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1413,
24,
971
]
],
[
[
1413,
24,
466
],
[
466,
62,
971
]
],
[
[
1413,
24,
1097
],
[
1097,
24,
971
]
],
[
[
1413,
24,
1339
],
[
1339,
... | [
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan an... |
DB06603 | DB11837 | 39 | 1,297 | [
"DDInter1387",
"DDInter1351"
] | Panobinostat | Osilodrostat | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
39,
25,
1297
]
],
[
[
39,
62,
112
],
[
112,
23,
1297
]
],
[
[
39,
24,
1320
],
[
1320,
63,
1297
]
],
[
[
39,
64,
623
],
[
623,
24... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Panobinostat",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Panobinostat may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and ... |
DB00655 | DB00877 | 559 | 629 | [
"DDInter682",
"DDInter1678"
] | Estrone | Sirolimus | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
559,
24,
629
]
],
[
[
559,
6,
4973
],
[
4973,
45,
629
]
],
[
[
559,
21,
28979
],
[
28979,
60,
629
]
],
[
[
559,
40,
1438
],
[
1438,
... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Estrone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"S... | Estrone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Estrone (Compound) causes Asthma (Side Effect) and Asthma (Side Effect) is caused by Sirolimus (Compound)
Estrone (Compound) resembles Estradiol (Compound) and Estradiol may cause a moderate interaction that could exacerbate disease... |
DB00683 | DB01105 | 1,382 | 222 | [
"DDInter1212",
"DDInter1665"
] | Midazolam | Sibutramine | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1382,
24,
222
]
],
[
[
1382,
6,
8374
],
[
8374,
45,
222
]
],
[
[
1382,
21,
29356
],
[
29356,
60,
222
]
],
[
[
1382,
25,
384
],
[
384,
... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Midazolam",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Midazolam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Midazolam (Compound) causes Salivary hypersecretion (Side Effect) and Salivary hypersecretion (Side Effect) is caused by Sibutramine (Compound)
Midazolam may lead to a major life threatening interaction when taken with Idelali... |
DB00674 | DB00857 | 1,516 | 1,387 | [
"DDInter802",
"DDInter1768"
] | Galantamine | Terbinafine | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Moderate | 1 | [
[
[
1516,
24,
1387
]
],
[
[
1516,
6,
8374
],
[
8374,
45,
1387
]
],
[
[
1516,
7,
2635
],
[
2635,
46,
1387
]
],
[
[
1516,
18,
15501
],
[
155... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terbinafine"
]
],
[
[
"Galantamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Galantamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Terbinafine (Compound)
Galantamine (Compound) upregulates MYLK (Gene) and MYLK (Gene) is upregulated by Terbinafine (Compound)
Galantamine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Terbinafine (Compound)
Galantam... |
DB00744 | DB12010 | 1,288 | 214 | [
"DDInter1962",
"DDInter785"
] | Zileuton | Fostamatinib | Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, a... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1288,
24,
214
]
],
[
[
1288,
24,
1362
],
[
1362,
24,
214
]
],
[
[
1288,
63,
1324
],
[
1324,
24,
214
]
],
[
[
1288,
24,
1017
],
[
1017,... | [
[
[
"Zileuton",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Zileuton",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Zileuton may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Zileuton may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazo... |
DB01284 | DB09045 | 1,042 | 52 | [
"DDInter1782",
"DDInter607"
] | Tetracosactide | Dulaglutide | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
1042,
24,
52
]
],
[
[
1042,
63,
170
],
[
170,
23,
52
]
],
[
[
1042,
24,
178
],
[
178,
24,
52
]
],
[
[
1042,
63,
674
],
[
674,
24... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide... |
DB08865 | DB09078 | 1,593 | 1,228 | [
"DDInter448",
"DDInter1036"
] | Crizotinib | Lenvatinib | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Major | 2 | [
[
[
1593,
25,
1228
]
],
[
[
1593,
63,
112
],
[
112,
23,
1228
]
],
[
[
1593,
64,
463
],
[
463,
23,
1228
]
],
[
[
1593,
62,
1247
],
[
1247,
... | [
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenvatinib"
]
],
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Crizotinib may lead to a major life threatening interaction when taken with Rifampicin and Rifampicin may ca... |
DB01259 | DB06717 | 392 | 875 | [
"DDInter1024",
"DDInter778"
] | Lapatinib | Fosaprepitant | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
392,
24,
875
]
],
[
[
392,
63,
723
],
[
723,
1,
875
]
],
[
[
392,
21,
29122
],
[
29122,
60,
875
]
],
[
[
392,
63,
222
],
[
222,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Lapatinib (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Fosaprepitant (Compound)
Lapatinib may caus... |
DB04865 | DB05578 | 4 | 330 | [
"DDInter1335",
"DDInter1566"
] | Omacetaxine mepesuccinate | Ramucirumab | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Major | 2 | [
[
[
4,
25,
330
]
],
[
[
4,
24,
384
],
[
384,
63,
330
]
],
[
[
4,
64,
1317
],
[
1317,
25,
330
]
],
[
[
4,
25,
397
],
[
397,
64,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ramucirumab"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Ramucirumab
Omacetaxine mepesuccinate may lead to a major life threatening interaction when taken with Dipyr... |
DB01263 | DB09030 | 859 | 840 | [
"DDInter1494",
"DDInter1945"
] | Posaconazole | Vorapaxar | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
859,
25,
840
]
],
[
[
859,
25,
1017
],
[
1017,
63,
840
]
],
[
[
859,
24,
1496
],
[
1496,
63,
840
]
],
[
[
859,
25,
578
],
[
578,
... | [
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
],
[
"Lorlatinib",
"{u... | Posaconazole may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nintedanib may cau... |
DB00041 | DB04835 | 1,648 | 1,655 | [
"DDInter38",
"DDInter1125"
] | Aldesleukin | Maraviroc | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Moderate | 1 | [
[
[
1648,
24,
1655
]
],
[
[
1648,
24,
1214
],
[
1214,
24,
1655
]
],
[
[
1648,
24,
850
],
[
850,
63,
1655
]
],
[
[
1648,
63,
305
],
[
305,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maraviroc"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Minoxidil"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Minoxidil and Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Maraviroc
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin an... |
DB00835 | DB01246 | 100 | 820 | [
"DDInter245",
"DDInter45"
] | Brompheniramine | Alimemazine | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
100,
24,
820
]
],
[
[
100,
35,
358
],
[
358,
24,
820
]
],
[
[
100,
24,
104
],
[
104,
40,
820
]
],
[
[
100,
63,
1335
],
[
1335,
2... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Brompheniramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases w... | Brompheniramine (Compound) resembles Orphenadrine (Compound) and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Brompheniramine may cause a moderate ... |
DB00334 | DB08824 | 867 | 591 | [
"DDInter1326",
"DDInter959"
] | Olanzapine | Ioflupane I-123 | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
867,
24,
591
]
],
[
[
867,
40,
1408
],
[
1408,
24,
591
]
],
[
[
867,
24,
401
],
[
401,
24,
591
]
],
[
[
867,
1,
623
],
[
623,
24... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Olanzapine",
"{u} (Compound) resembles {v} (Compound)",
"Loxapine"
],
[
"Loxapine",
"{u} may cause a modera... | Olanzapine (Compound) resembles Loxapine (Compound) and Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that ... |
DB00215 | DB00468 | 1,230 | 1,424 | [
"DDInter388",
"DDInter1557"
] | Citalopram | Quinine | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Major | 2 | [
[
[
1230,
25,
1424
]
],
[
[
1230,
6,
6365
],
[
6365,
45,
1424
]
],
[
[
1230,
21,
29316
],
[
29316,
60,
1424
]
],
[
[
1230,
23,
112
],
[
11... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinine"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compound)",
"Quinine"
... | Citalopram (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Quinine (Compound)
Citalopram (Compound) causes Sweating (Side Effect) and Sweating (Side Effect) is caused by Quinine (Compound)
Citalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazo... |
DB01004 | DB01087 | 563 | 1,520 | [
"DDInter806",
"DDInter1520"
] | Ganciclovir | Primaquine | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
563,
24,
1520
]
],
[
[
563,
21,
28722
],
[
28722,
60,
1520
]
],
[
[
563,
24,
1342
],
[
1342,
63,
1520
]
],
[
[
563,
63,
322
],
[
322,
... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Ganciclovir",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused b... | Ganciclovir (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Primaquine (Compound)
Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Primaquine
... |
DB00843 | DB08881 | 479 | 868 | [
"DDInter583",
"DDInter1925"
] | Donepezil | Vemurafenib | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Minor | 0 | [
[
[
479,
23,
868
]
],
[
[
479,
6,
8374
],
[
8374,
45,
868
]
],
[
[
479,
7,
3361
],
[
3361,
46,
868
]
],
[
[
479,
18,
16974
],
[
16974,
... | [
[
[
"Donepezil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vemurafenib"
]
],
[
[
"Donepezil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Donepezil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Donepezil (Compound) upregulates NFIL3 (Gene) and NFIL3 (Gene) is upregulated by Vemurafenib (Compound)
Donepezil (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Vemurafenib (Compound)
Donepezil (Com... |
DB01172 | DB01337 | 416 | 1,579 | [
"DDInter1004",
"DDInter1385"
] | Kanamycin | Pancuronium | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release. | Major | 2 | [
[
[
416,
25,
1579
]
],
[
[
416,
64,
1610
],
[
1610,
1,
1579
]
],
[
[
416,
25,
728
],
[
728,
1,
1579
]
],
[
[
416,
18,
18226
],
[
18226,
... | [
[
[
"Kanamycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pancuronium"
]
],
[
[
"Kanamycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rocuronium"
],
[
"Rocuronium",
"{u} (C... | Kanamycin may lead to a major life threatening interaction when taken with Rocuronium and Rocuronium (Compound) resembles Pancuronium (Compound)
Kanamycin may lead to a major life threatening interaction when taken with Vecuronium and Vecuronium (Compound) resembles Pancuronium (Compound)
Kanamycin (Compound) downregul... |
DB00207 | DB00604 | 1,570 | 1,425 | [
"DDInter157",
"DDInter385"
] | Azithromycin | Cisapride | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Major | 2 | [
[
[
1570,
25,
1425
]
],
[
[
1570,
6,
8717
],
[
8717,
45,
1425
]
],
[
[
1570,
18,
12106
],
[
12106,
57,
1425
]
],
[
[
1570,
23,
112
],
[
11... | [
[
[
"Azithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisapride"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP2A6"
],
[
"CYP2A6",
"{u} (Gene) is bound by {v} (Compound)",
"Cisa... | Azithromycin (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Cisapride (Compound)
Azithromycin (Compound) downregulates NT5DC2 (Gene) and NT5DC2 (Gene) is downregulated by Cisapride (Compound)
Azithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metro... |
DB00065 | DB09312 | 581 | 967 | [
"DDInter923",
"DDInter103"
] | Infliximab | Antilymphocyte immunoglobulin (horse) | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Equine anti-thymocyte globulin is composed of purified gamma globulin containing primarily IgG against human thymus lymphocytes. It is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system's B-lymphocytes to produce IgG immunoglobulins specific for that antigen. The... | Major | 2 | [
[
[
581,
25,
967
]
],
[
[
581,
23,
1193
],
[
1193,
62,
967
]
],
[
[
581,
25,
1683
],
[
1683,
24,
967
]
],
[
[
581,
25,
1531
],
[
1531,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Antilymphocyte immunoglobulin (horse)"
]
],
[
[
"Infliximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
... | Infliximab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Antilymphocyte immunoglobulin (horse)
Infliximab may lead to a major life threatening interaction when taken with Ustek... |
DB06589 | DB09472 | 1,250 | 1,383 | [
"DDInter1400",
"DDInter1693"
] | Pazopanib | Sodium sulfate | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1250,
24,
1383
]
],
[
[
1250,
64,
609
],
[
609,
24,
1383
]
],
[
[
1250,
63,
521
],
[
521,
24,
1383
]
],
[
[
1250,
24,
1613
],
[
1613,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Clar... | Pazopanib may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin ma... |
DB00477 | DB00668 | 216 | 874 | [
"DDInter363",
"DDInter652"
] | Chlorpromazine | Epinephrine | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
216,
24,
874
]
],
[
[
216,
24,
688
],
[
688,
63,
874
]
],
[
[
216,
6,
7950
],
[
7950,
45,
874
]
],
[
[
216,
7,
7669
],
[
7669,
4... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine
Chlorpromazine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Epinephrine (Compound)
Chlorpro... |
DB00400 | DB00877 | 353 | 629 | [
"DDInter843",
"DDInter1678"
] | Griseofulvin | Sirolimus | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
353,
24,
629
]
],
[
[
353,
6,
8374
],
[
8374,
45,
629
]
],
[
[
353,
18,
15501
],
[
15501,
57,
629
]
],
[
[
353,
21,
28921
],
[
28921,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Griseofulvin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Griseofulvin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sirolimus (Compound)
Griseofulvin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Sirolimus (Compound)
Griseofulvin (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Sirolimus (Compoun... |
DB00687 | DB01122 | 870 | 158 | [
"DDInter747",
"DDInter61"
] | Fludrocortisone | Ambenonium | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis. | Moderate | 1 | [
[
[
870,
24,
158
]
],
[
[
870,
1,
251
],
[
251,
24,
158
]
],
[
[
870,
25,
1011
],
[
1011,
63,
158
]
],
[
[
870,
1,
1220
],
[
1220,
6... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ambenonium"
]
],
[
[
"Fludrocortisone",
"{u} (Compound) resembles {v} (Compound)",
"Betamethasone"
],
[
"Betamethasone",
"{u} may... | Fludrocortisone (Compound) resembles Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ambenonium
Fludrocortisone may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that coul... |
DB08913 | DB11581 | 1,186 | 1,456 | [
"DDInter1561",
"DDInter1926"
] | Radium Ra 223 dichloride | Venetoclax | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
1186,
24,
1456
]
],
[
[
1186,
63,
594
],
[
594,
24,
1456
]
],
[
[
1186,
24,
738
],
[
738,
63,
1456
]
],
[
[
1186,
24,
951
],
[
951,
... | [
[
[
"Radium Ra 223 dichloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Radium Ra 223 dichloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Radium Ra 223 dichloride may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Radium Ra 223 dichloride may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00549 | DB01229 | 522 | 973 | [
"DDInter1955",
"DDInter1378"
] | Zafirlukast | Paclitaxel (protein-bound) | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
522,
24,
973
]
],
[
[
522,
24,
310
],
[
310,
63,
973
]
],
[
[
522,
6,
8374
],
[
8374,
45,
973
]
],
[
[
522,
21,
28643
],
[
28643,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Zafirl... |
DB00585 | DB00939 | 1,127 | 1,338 | [
"DDInter1309",
"DDInter1135"
] | Nizatidine | Meclofenamic acid | A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Minor | 0 | [
[
[
1127,
23,
1338
]
],
[
[
1127,
7,
7720
],
[
7720,
45,
1338
]
],
[
[
1127,
18,
6212
],
[
6212,
57,
1338
]
],
[
[
1127,
21,
28900
],
[
28... | [
[
[
"Nizatidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Meclofenamic acid"
]
],
[
[
"Nizatidine",
"{u} (Compound) upregulates {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is bound by {v} (Co... | Nizatidine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Meclofenamic acid (Compound)
Nizatidine (Compound) downregulates CSRP1 (Gene) and CSRP1 (Gene) is downregulated by Meclofenamic acid (Compound)
Nizatidine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused... |
DB01236 | DB11837 | 679 | 1,297 | [
"DDInter1664",
"DDInter1351"
] | Sevoflurane | Osilodrostat | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
679,
24,
1297
]
],
[
[
679,
62,
112
],
[
112,
23,
1297
]
],
[
[
679,
63,
401
],
[
401,
24,
1297
]
],
[
[
679,
24,
657
],
[
657,
... | [
[
[
"Sevoflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Sevoflurane",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Sevoflurane may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Sevoflurane may cause a moderate interaction that could exacerbate diseases when taken with Promethazine an... |
DB00574 | DB01240 | 121 | 885 | [
"DDInter717",
"DDInter657"
] | Fenfluramine | Epoprostenol | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
121,
24,
885
]
],
[
[
121,
63,
1061
],
[
1061,
1,
885
]
],
[
[
121,
24,
1512
],
[
1512,
24,
885
]
],
[
[
121,
24,
397
],
[
397,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction ... |
DB01125 | DB06228 | 279 | 792 | [
"DDInter98",
"DDInter1609"
] | Anisindione | Rivaroxaban | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
279,
25,
792
]
],
[
[
279,
63,
752
],
[
752,
24,
792
]
],
[
[
279,
24,
557
],
[
557,
24,
792
]
],
[
[
279,
24,
738
],
[
738,
63,... | [
[
[
"Anisindione",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Anisindione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],
[
"Cimetid... | Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban
Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid a... |
DB00108 | DB08908 | 1,066 | 713 | [
"DDInter1268",
"DDInter564"
] | Natalizumab | Dimethyl fumarate | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Major | 2 | [
[
[
1066,
25,
713
]
],
[
[
1066,
24,
996
],
[
996,
24,
713
]
],
[
[
1066,
25,
1083
],
[
1083,
24,
713
]
],
[
[
1066,
64,
1394
],
[
1394,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Natalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
],
[
"... | Natalizumab may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Natalizumab may lead to a major life threatening interaction when taken with Trifluridine and Trifluri... |
DB00544 | DB15965 | 970 | 1,330 | [
"DDInter757",
"DDInter1270"
] | Fluorouracil | Naxitamab | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Moderate | 1 | [
[
[
970,
24,
1330
]
],
[
[
970,
24,
1532
],
[
1532,
24,
1330
]
],
[
[
970,
63,
597
],
[
597,
24,
1330
]
],
[
[
970,
25,
770
],
[
770,
... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naxitamab"
]
],
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[... | Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab
Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol an... |
DB00331 | DB00334 | 1,645 | 867 | [
"DDInter1164",
"DDInter1326"
] | Metformin | Olanzapine | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Moderate | 1 | [
[
[
1645,
24,
867
]
],
[
[
1645,
24,
695
],
[
695,
40,
867
]
],
[
[
1645,
24,
1616
],
[
1616,
63,
867
]
],
[
[
1645,
62,
1647
],
[
1647,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olanzapine"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Olanzapine (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and Histrelin may cause a moderate interaction that could exace... |
DB00407 | DB08816 | 202 | 578 | [
"DDInter115",
"DDInter1802"
] | Ardeparin | Ticagrelor | Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Major | 2 | [
[
[
202,
25,
578
]
],
[
[
202,
21,
28762
],
[
28762,
60,
578
]
],
[
[
202,
64,
1578
],
[
1578,
24,
578
]
],
[
[
202,
25,
1347
],
[
1347,
... | [
[
[
"Ardeparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ticagrelor"
]
],
[
[
"Ardeparin",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by {v} (Compound... | Ardeparin (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ticagrelor (Compound)
Ardeparin may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor
Ardeparin may lea... |
DB06603 | DB10989 | 39 | 496 | [
"DDInter1387",
"DDInter858"
] | Panobinostat | Hepatitis A Vaccine | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
39,
24,
496
]
],
[
[
39,
63,
4
],
[
4,
24,
496
]
],
[
[
39,
24,
850
],
[
850,
24,
496
]
],
[
[
39,
64,
77
],
[
77,
24,
496... | [
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine me... | Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Panobinostat may cause a moderate interaction that could exacerbate dis... |
DB00653 | DB01070 | 544 | 1,098 | [
"DDInter1120",
"DDInter558"
] | Magnesium sulfate | Dihydrotachysterol | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | A vitamin D that can be regarded as a reduction product of vitamin D2. | Moderate | 1 | [
[
[
544,
24,
1098
]
],
[
[
544,
63,
386
],
[
386,
25,
1098
]
],
[
[
544,
24,
1041
],
[
1041,
25,
1098
]
],
[
[
544,
24,
460
],
[
460,
... | [
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dihydrotachysterol"
]
],
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chole... | Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Dihydrotachysterol
Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Pari... |
DB00283 | DB01403 | 701 | 9 | [
"DDInter395",
"DDInter1175"
] | Clemastine | Methotrimeprazine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
701,
24,
9
]
],
[
[
701,
24,
1178
],
[
1178,
40,
9
]
],
[
[
701,
24,
1164
],
[
1164,
1,
9
]
],
[
[
701,
24,
401
],
[
401,
24,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles M... |
DB00035 | DB11130 | 1,314 | 407 | [
"DDInter507",
"DDInter1344"
] | Desmopressin | Opium | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1314,
24,
407
]
],
[
[
1314,
24,
529
],
[
529,
24,
407
]
],
[
[
1314,
24,
180
],
[
180,
63,
407
]
],
[
[
1314,
25,
1028
],
[
1028,
... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvoxamine"
],
[
... | Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine and Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine and Olic... |
DB00736 | DB01583 | 660 | 624 | [
"DDInter676",
"DDInter1075"
] | Esomeprazole | Liotrix | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Moderate | 1 | [
[
[
660,
24,
624
]
],
[
[
660,
63,
1152
],
[
1152,
1,
624
]
],
[
[
660,
63,
542
],
[
542,
40,
624
]
],
[
[
660,
7,
13230
],
[
13230,
... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
]
],
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
],
[... | Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine (Compound) resembles Liotrix (Compound)
Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levothyroxine (Compound) resembles Liotrix (Co... |
DB01409 | DB09076 | 1,415 | 1,116 | [
"DDInter1815",
"DDInter1899"
] | Tiotropium | Umeclidinium | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
1415,
24,
1116
]
],
[
[
1415,
24,
849
],
[
849,
24,
1116
]
],
[
[
1415,
63,
1300
],
[
1300,
24,
1116
]
],
[
[
1415,
35,
1429
],
[
1429... | [
[
[
"Tiotropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Tiotropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Tiotropium may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Tiotropium may cause a moderate interaction that could exacerbate diseases when taken with Haloperidol and Hal... |
DB00717 | DB11718 | 1,197 | 927 | [
"DDInter1312",
"DDInter640"
] | Norethisterone | Encorafenib | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
1197,
25,
927
]
],
[
[
1197,
63,
1324
],
[
1324,
24,
927
]
],
[
[
1197,
24,
484
],
[
484,
63,
927
]
],
[
[
1197,
24,
761
],
[
761,
... | [
[
[
"Norethisterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[
... | Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Entrecti... |
DB01073 | DB08895 | 1,488 | 976 | [
"DDInter745",
"DDInter1825"
] | Fludarabine | Tofacitinib | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
1488,
25,
976
]
],
[
[
1488,
63,
1461
],
[
1461,
23,
976
]
],
[
[
1488,
24,
200
],
[
200,
63,
976
]
],
[
[
1488,
63,
1252
],
[
1252,
... | [
[
[
"Fludarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin ... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and C... |
DB00295 | DB01200 | 475 | 469 | [
"DDInter1244",
"DDInter243"
] | Morphine | Bromocriptine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Moderate | 1 | [
[
[
475,
24,
469
]
],
[
[
475,
6,
8374
],
[
8374,
45,
469
]
],
[
[
475,
21,
29862
],
[
29862,
60,
469
]
],
[
[
475,
24,
401
],
[
401,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromocriptine"
]
],
[
[
"Morphine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Morphine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bromocriptine (Compound)
Morphine (Compound) causes Taste metallic (Side Effect) and Taste metallic (Side Effect) is caused by Bromocriptine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Promethaz... |
DB01227 | DB11986 | 1,301 | 484 | [
"DDInter1043",
"DDInter648"
] | Levacetylmethadol | Entrectinib | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
1301,
25,
484
]
],
[
[
1301,
62,
112
],
[
112,
23,
484
]
],
[
[
1301,
63,
222
],
[
222,
23,
484
]
],
[
[
1301,
25,
774
],
[
774,
... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Levacetylmethadol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Levacetylmethadol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Levacetylmethadol may cause a moderate interaction that could exacerbate diseases when taken with Sibu... |
DB00283 | DB04837 | 701 | 649 | [
"DDInter395",
"DDInter407"
] | Clemastine | Clofedanol | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
701,
24,
649
]
],
[
[
701,
24,
1376
],
[
1376,
24,
649
]
],
[
[
701,
25,
675
],
[
675,
40,
649
]
],
[
[
701,
24,
1301
],
[
1301,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Clemastine may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dex... |
DB00861 | DB00945 | 914 | 1,479 | [
"DDInter551",
"DDInter20"
] | Diflunisal | Acetylsalicylic acid | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
914,
24,
1479
]
],
[
[
914,
1,
11404
],
[
11404,
40,
1479
]
],
[
[
914,
40,
345
],
[
345,
40,
1479
]
],
[
[
914,
6,
1829
],
[
1829,
... | [
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Diflunisal",
"{u} (Compound) resembles {v} (Compound)",
"Salicylic acid"
],
[
"Salicylic acid",
"{u} (... | Diflunisal (Compound) resembles Salicylic acid (Compound) and Salicylic acid (Compound) resembles Acetylsalicylic acid (Compound)
Diflunisal (Compound) resembles Salsalate (Compound) and Salsalate (Compound) resembles Acetylsalicylic acid (Compound)
Diflunisal (Compound) binds ALB (Gene) and ALB (Gene) is bound by Acet... |
DB00208 | DB11793 | 1,018 | 738 | [
"DDInter1804",
"DDInter1297"
] | Ticlopidine | Niraparib | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
1018,
24,
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]
],
[
[
1018,
25,
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],
[
1213,
24,
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]
],
[
[
1018,
64,
1578
],
[
1578,
24,
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]
],
[
[
1018,
24,
848
],
[
848,
... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Ticlopidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib"... | Ticlopidine may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Ticlopidine may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interac... |
DB01168 | DB08918 | 1,053 | 41 | [
"DDInter1526",
"DDInter1059"
] | Procarbazine | Levomilnacipran | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Major | 2 | [
[
[
1053,
25,
41
]
],
[
[
1053,
25,
901
],
[
901,
40,
41
]
],
[
[
1053,
64,
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],
[
1349,
40,
41
]
],
[
[
1053,
21,
28643
],
[
28643,
... | [
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Milnacipran"
],
[
"Milnacipran",
... | Procarbazine may lead to a major life threatening interaction when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Procarbazine may lead to a major life threatening interaction when taken with Meperidine and Meperidine (Compound) resembles Levomilnacipran (Compound)
Procarbazine (... |
DB00570 | DB10276 | 147 | 1,624 | [
"DDInter1936",
"DDInter1623"
] | Vinblastine | Rotavirus vaccine | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
147,
25,
1624
]
],
[
[
147,
63,
552
],
[
552,
25,
1624
]
],
[
[
147,
24,
1307
],
[
1307,
25,
1624
]
],
[
[
147,
64,
1648
],
[
1648,
... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
],
[
"C... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Carmustine may lead to a major life threatening interaction when taken with Rotavirus vaccine
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan may... |
DB00023 | DB00975 | 305 | 1,317 | [
"DDInter127",
"DDInter573"
] | Asparaginase Escherichia coli | Dipyridamole | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Moderate | 1 | [
[
[
305,
24,
1317
]
],
[
[
305,
24,
1496
],
[
1496,
63,
1317
]
],
[
[
305,
24,
311
],
[
311,
24,
1317
]
],
[
[
305,
25,
1064
],
[
1064,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dipyridamole"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseas... |
DB00836 | DB08875 | 543 | 1,618 | [
"DDInter1088",
"DDInter262"
] | Loperamide | Cabozantinib | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Moderate | 1 | [
[
[
543,
24,
1618
]
],
[
[
543,
24,
112
],
[
112,
23,
1618
]
],
[
[
543,
25,
384
],
[
384,
63,
1618
]
],
[
[
543,
64,
122
],
[
122,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Loperamide may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may ... |
DB00477 | DB00515 | 216 | 589 | [
"DDInter363",
"DDInter387"
] | Chlorpromazine | Cisplatin | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Moderate | 1 | [
[
[
216,
24,
589
]
],
[
[
216,
6,
10558
],
[
10558,
45,
589
]
],
[
[
216,
21,
28778
],
[
28778,
60,
589
]
],
[
[
216,
1,
684
],
[
684,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) binds {v} (Gene)",
"BCHE"
],
[
"BCHE",
"{u} (Gene) is bound by {v} (Compound... | Chlorpromazine (Compound) binds BCHE (Gene) and BCHE (Gene) is bound by Cisplatin (Compound)
Chlorpromazine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Cisplatin (Compound)
Chlorpromazine (Compound) resembles Thioridazine (Compound) and Thioridazine may cause a m... |
DB00307 | DB08870 | 1,101 | 850 | [
"DDInter202",
"DDInter228"
] | Bexarotene | Brentuximab vedotin | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1101,
24,
850
]
],
[
[
1101,
24,
496
],
[
496,
63,
850
]
],
[
[
1101,
24,
896
],
[
896,
24,
850
]
],
[
[
1101,
23,
859
],
[
859,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccin... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken... |
DB00687 | DB01319 | 870 | 34 | [
"DDInter747",
"DDInter777"
] | Fludrocortisone | Fosamprenavir | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Moderate | 1 | [
[
[
870,
24,
34
]
],
[
[
870,
24,
1091
],
[
1091,
40,
34
]
],
[
[
870,
21,
28835
],
[
28835,
60,
34
]
],
[
[
870,
24,
609
],
[
609,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Fludrocortisone (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Fosamprenavir (Compound)
Fludrocortisone ma... |
DB06168 | DB09570 | 1,531 | 1,480 | [
"DDInter281",
"DDInter1002"
] | Canakinumab | Ixazomib | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
1531,
24,
1480
]
],
[
[
1531,
24,
987
],
[
987,
63,
1480
]
],
[
[
1531,
63,
453
],
[
453,
24,
1480
]
],
[
[
1531,
24,
1136
],
[
1136,
... | [
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR... | Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen and Vibrio cholerae CVD 103-HgR strain live antigen may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Canakinumab may cause a moderate intera... |
DB00580 | DB00916 | 311 | 112 | [
"DDInter1910",
"DDInter1202"
] | Valdecoxib | Metronidazole | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Moderate | 1 | [
[
[
311,
24,
112
]
],
[
[
311,
63,
752
],
[
752,
23,
112
]
],
[
[
311,
24,
477
],
[
477,
62,
112
]
],
[
[
311,
24,
1144
],
[
1144,
2... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],
[... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilos... |
DB01082 | DB01226 | 1,448 | 1,319 | [
"DDInter1713",
"DDInter1235"
] | Streptomycin | Mivacurium | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Mivacurium is a bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant. It binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission. | Major | 2 | [
[
[
1448,
25,
1319
]
],
[
[
1448,
25,
648
],
[
648,
1,
1319
]
],
[
[
1448,
21,
29232
],
[
29232,
60,
1319
]
],
[
[
1448,
64,
1441
],
[
144... | [
[
[
"Streptomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mivacurium"
]
],
[
[
"Streptomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxacurium"
],
[
"Doxacurium",
"{... | Streptomycin may lead to a major life threatening interaction when taken with Doxacurium and Doxacurium (Compound) resembles Mivacurium (Compound)
Streptomycin (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Mivacurium (Compound)
Streptomycin may lead to a major life threatening inter... |
DB01155 | DB12141 | 872 | 971 | [
"DDInter813",
"DDInter817"
] | Gemifloxacin | Gilteritinib | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
872,
24,
971
]
],
[
[
872,
62,
112
],
[
112,
23,
971
]
],
[
[
872,
63,
485
],
[
485,
24,
971
]
],
[
[
872,
24,
823
],
[
823,
63,... | [
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Gemifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Gemifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Gemifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine a... |
DB00827 | DB00851 | 646 | 611 | [
"DDInter383",
"DDInter463"
] | Cinoxacin | Dacarbazine | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Minor | 0 | [
[
[
646,
23,
611
]
],
[
[
646,
62,
141
],
[
141,
24,
611
]
],
[
[
646,
23,
77
],
[
77,
63,
611
]
],
[
[
646,
63,
663
],
[
663,
24,
... | [
[
[
"Cinoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dacarbazine"
]
],
[
[
"Cinoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Floxuridine"
],
[
... | Cinoxacin may cause a minor interaction that can limit clinical effects when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Dacarbazine
Cinoxacin may cause a minor interaction that can limit clinical effects when taken with Idarubicin and Idarubici... |
DB06697 | DB12887 | 436 | 1,598 | [
"DDInter121",
"DDInter1750"
] | Artemether | Tazemetostat | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
436,
24,
1598
]
],
[
[
436,
24,
1476
],
[
1476,
24,
1598
]
],
[
[
436,
63,
1324
],
[
1324,
24,
1598
]
],
[
[
436,
24,
159
],
[
159,
... | [
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Artemether may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat
Artemether may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Tr... |
DB00357 | DB00675 | 1,051 | 888 | [
"DDInter71",
"DDInter1744"
] | Aminoglutethimide | Tamoxifen | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Moderate | 1 | [
[
[
1051,
24,
888
]
],
[
[
1051,
6,
10215
],
[
10215,
45,
888
]
],
[
[
1051,
21,
29232
],
[
29232,
60,
888
]
],
[
[
1051,
24,
1135
],
[
11... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {... | Aminoglutethimide (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Tamoxifen (Compound)
Aminoglutethimide (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Tamoxifen (Compound)
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00470 | DB00705 | 530 | 441 | [
"DDInter601",
"DDInter496"
] | Dronabinol | Delavirdine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Minor | 0 | [
[
[
530,
23,
441
]
],
[
[
530,
6,
10215
],
[
10215,
45,
441
]
],
[
[
530,
21,
28709
],
[
28709,
60,
441
]
],
[
[
530,
24,
222
],
[
222,
... | [
[
[
"Dronabinol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Delavirdine"
]
],
[
[
"Dronabinol",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)"... | Dronabinol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Delavirdine (Compound)
Dronabinol (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Delavirdine (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00319 | DB01017 | 790 | 1,669 | [
"DDInter1474",
"DDInter1224"
] | Piperacillin | Minocycline | Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Moderate | 1 | [
[
[
790,
24,
1669
]
],
[
[
790,
24,
1572
],
[
1572,
1,
1669
]
],
[
[
790,
63,
964
],
[
964,
1,
1669
]
],
[
[
790,
24,
1545
],
[
1545,
... | [
[
[
"Piperacillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Minocycline"
]
],
[
[
"Piperacillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
],... | Piperacillin may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Minocycline (Compound)
Piperacillin may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline (Compound) resembles Minocyc... |
DB01021 | DB09268 | 674 | 1,662 | [
"DDInter1861",
"DDInter1464"
] | Trichlormethiazide | Picosulfuric acid | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
674,
24,
1662
]
],
[
[
674,
24,
708
],
[
708,
24,
1662
]
],
[
[
674,
63,
1573
],
[
1573,
24,
1662
]
],
[
[
674,
40,
504
],
[
504,
... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cort... | Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when tak... |
DB05812 | DB11837 | 1,374 | 1,297 | [
"DDInter8",
"DDInter1351"
] | Abiraterone | Osilodrostat | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1374,
24,
1297
]
],
[
[
1374,
23,
1135
],
[
1135,
23,
1297
]
],
[
[
1374,
62,
112
],
[
112,
23,
1297
]
],
[
[
1374,
23,
466
],
[
466,
... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Abiraterone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Abiraterone may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Abiraterone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metroni... |
DB00738 | DB01309 | 485 | 1,254 | [
"DDInter1420",
"DDInter933"
] | Pentamidine | Insulin glulisine | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
485,
24,
1254
]
],
[
[
485,
63,
1424
],
[
1424,
24,
1254
]
],
[
[
485,
23,
1247
],
[
1247,
24,
1254
]
],
[
[
485,
24,
480
],
[
480,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Pentamidine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and... |
DB00717 | DB06206 | 1,197 | 1,268 | [
"DDInter1312",
"DDInter1719"
] | Norethisterone | Sugammadex | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general ane... | Major | 2 | [
[
[
1197,
25,
1268
]
],
[
[
1197,
1,
615
],
[
615,
64,
1268
]
],
[
[
1197,
40,
1657
],
[
1657,
25,
1268
]
],
[
[
1197,
1,
1336
],
[
1336,
... | [
[
[
"Norethisterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sugammadex"
]
],
[
[
"Norethisterone",
"{u} (Compound) resembles {v} (Compound)",
"Norelgestromin"
],
[
"Norelgestromin",
"{u} may lead to a majo... | Norethisterone (Compound) resembles Norelgestromin (Compound) and Norelgestromin may lead to a major life threatening interaction when taken with Sugammadex
Norethisterone (Compound) resembles Desogestrel (Compound) and Desogestrel may lead to a major life threatening interaction when taken with Sugammadex
Norethistero... |
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