drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00531 | DB00564 | 450 | 1,236 | [
"DDInter456",
"DDInter293"
] | Cyclophosphamide | Carbamazepine | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
450,
24,
1236
]
],
[
[
450,
23,
307
],
[
307,
1,
1236
]
],
[
[
450,
63,
362
],
[
362,
1,
1236
]
],
[
[
450,
24,
1335
],
[
1335,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
... | Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Carbamazepine (Compound)
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Carbamazepine... |
DB01080 | DB01105 | 855 | 222 | [
"DDInter1933",
"DDInter1665"
] | Vigabatrin | Sibutramine | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
855,
24,
222
]
],
[
[
855,
21,
29356
],
[
29356,
60,
222
]
],
[
[
855,
63,
128
],
[
128,
24,
222
]
],
[
[
855,
24,
1311
],
[
1311,
... | [
[
[
"Vigabatrin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Vigabatrin",
"{u} (Compound) causes {v} (Side Effect)",
"Salivary hypersecretion"
],
[
"Salivary hypersecretion",
... | Vigabatrin (Compound) causes Salivary hypersecretion (Side Effect) and Salivary hypersecretion (Side Effect) is caused by Sibutramine (Compound)
Vigabatrin may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interaction that coul... |
DB00531 | DB00685 | 450 | 1,299 | [
"DDInter456",
"DDInter1887"
] | Cyclophosphamide | Trovafloxacin | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Minor | 0 | [
[
[
450,
23,
1299
]
],
[
[
450,
23,
872
],
[
872,
40,
1299
]
],
[
[
450,
62,
1467
],
[
1467,
40,
1299
]
],
[
[
450,
21,
29028
],
[
29028,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trovafloxacin"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
... | Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Trovafloxac... |
DB00975 | DB09075 | 1,317 | 498 | [
"DDInter573",
"DDInter621"
] | Dipyridamole | Edoxaban | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
1317,
25,
498
]
],
[
[
1317,
23,
944
],
[
944,
62,
498
]
],
[
[
1317,
24,
41
],
[
41,
24,
498
]
],
[
[
1317,
63,
109
],
[
109,
2... | [
[
[
"Dipyridamole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Dipyridamole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",... | Dipyridamole may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Edoxaban
Dipyridamole may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levom... |
DB08827 | DB11986 | 990 | 484 | [
"DDInter1085",
"DDInter648"
] | Lomitapide | Entrectinib | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
990,
25,
484
]
],
[
[
990,
23,
1135
],
[
1135,
23,
484
]
],
[
[
990,
63,
322
],
[
322,
24,
484
]
],
[
[
990,
25,
1320
],
[
1320,
... | [
[
[
"Lomitapide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Lomitapide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Lomitapide may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Lomitapide may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin ... |
DB00495 | DB00681 | 139 | 1,287 | [
"DDInter1961",
"DDInter85"
] | Zidovudine | Amphotericin B | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Moderate | 1 | [
[
[
139,
24,
1287
]
],
[
[
139,
21,
29196
],
[
29196,
60,
1287
]
],
[
[
139,
63,
600
],
[
600,
23,
1287
]
],
[
[
139,
24,
663
],
[
663,
... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphotericin B"
]
],
[
[
"Zidovudine",
"{u} (Compound) causes {v} (Side Effect)",
"Paraesthesia"
],
[
"Paraesthesia",
"{u} (Side Effec... | Zidovudine (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Amphotericin B (Compound)
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken wi... |
DB00218 | DB08882 | 1,176 | 1,281 | [
"DDInter1247",
"DDInter1070"
] | Moxifloxacin | Linagliptin | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
1176,
24,
1281
]
],
[
[
1176,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
1176,
21,
29081
],
[
29081,
60,
1281
]
],
[
[
1176,
25,
251
],
[
25... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
... | Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Moxifloxacin (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Linagliptin (Compound)
Moxifloxacin may lead to a major lif... |
DB00214 | DB12332 | 1,028 | 1,619 | [
"DDInter1836",
"DDInter1626"
] | Torasemide | Rucaparib | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1028,
24,
1619
]
],
[
[
1028,
24,
222
],
[
222,
23,
1619
]
],
[
[
1028,
24,
1662
],
[
1662,
24,
1619
]
],
[
[
1028,
63,
1324
],
[
1324... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and ... |
DB00372 | DB01381 | 999 | 958 | [
"DDInter1793",
"DDInter819"
] | Thiethylperazine | Ginkgo biloba | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
999,
24,
958
]
],
[
[
999,
63,
73
],
[
73,
24,
958
]
],
[
[
999,
24,
1466
],
[
1466,
24,
958
]
],
[
[
999,
25,
593
],
[
593,
24,... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentermine"... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Phen... |
DB00543 | DB11901 | 87 | 913 | [
"DDInter82",
"DDInter107"
] | Amoxapine | Apalutamide | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
87,
24,
913
]
],
[
[
87,
23,
112
],
[
112,
23,
913
]
],
[
[
87,
63,
600
],
[
600,
24,
913
]
],
[
[
87,
24,
485
],
[
485,
24,
... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Amoxapine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Amoxapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluc... |
DB01186 | DB01619 | 107 | 830 | [
"DDInter1430",
"DDInter1441"
] | Pergolide | Phenindamine | Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic tr... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
107,
24,
830
]
],
[
[
107,
63,
537
],
[
537,
40,
830
]
],
[
[
107,
63,
13
],
[
13,
24,
830
]
],
[
[
107,
63,
104
],
[
104,
1,
... | [
[
[
"Pergolide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Pergolide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Pergolide may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Pergolide may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that... |
DB00467 | DB00585 | 1,467 | 1,127 | [
"DDInter644",
"DDInter1309"
] | Enoxacin | Nizatidine | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. | Minor | 0 | [
[
[
1467,
23,
1127
]
],
[
[
1467,
23,
1194
],
[
1194,
40,
1127
]
],
[
[
1467,
18,
5660
],
[
5660,
57,
1127
]
],
[
[
1467,
24,
1274
],
[
12... | [
[
[
"Enoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nizatidine"
]
],
[
[
"Enoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
],
[
"Ran... | Enoxacin may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranitidine (Compound) resembles Nizatidine (Compound)
Enoxacin (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is downregulated by Nizatidine (Compound)
Enoxacin may cause a moderate interaction that could exace... |
DB00865 | DB06704 | 939 | 247 | [
"DDInter187",
"DDInter952"
] | Benzphetamine | Iobenguane (I-131) | A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Major | 2 | [
[
[
939,
37,
247
]
],
[
[
939,
6,
7390
],
[
7390,
45,
247
]
],
[
[
939,
21,
28921
],
[
28921,
60,
247
]
],
[
[
939,
24,
820
],
[
820,
... | [
[
[
"Benzphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Benzphetamine",
"{u} (Compound) binds {v} (Gene)",
"... | Benzphetamine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Benzphetamine may lead to a major life threatening interaction when taken with Iobenguane
Benzphetamine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Benzphetamine (Compound)... |
DB00333 | DB00835 | 576 | 100 | [
"DDInter1166",
"DDInter245"
] | Methadone | Brompheniramine | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
576,
24,
100
]
],
[
[
576,
35,
832
],
[
832,
24,
100
]
],
[
[
576,
24,
128
],
[
128,
24,
100
]
],
[
[
576,
40,
11244
],
[
11244,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Methadone",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when take... | Methadone (Compound) resembles Tripelennamine (Compound) and Methadone may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Methadone may cause a moderate interact... |
DB00041 | DB00476 | 1,648 | 109 | [
"DDInter38",
"DDInter608"
] | Aldesleukin | Duloxetine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Moderate | 1 | [
[
[
1648,
24,
109
]
],
[
[
1648,
24,
758
],
[
758,
1,
109
]
],
[
[
1648,
24,
1376
],
[
1376,
63,
109
]
],
[
[
1648,
24,
1594
],
[
1594,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fluoxetine (Compound) resembles Duloxetine (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interactio... |
DB00247 | DB00759 | 1,131 | 1,620 | [
"DDInter1194",
"DDInter1783"
] | Methysergide | Tetracycline | An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize sero... | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Moderate | 1 | [
[
[
1131,
24,
1620
]
],
[
[
1131,
24,
1572
],
[
1572,
40,
1620
]
],
[
[
1131,
40,
588
],
[
588,
24,
1620
]
],
[
[
1131,
25,
384
],
[
384,
... | [
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracycline"
]
],
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
]... | Methysergide may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Tetracycline (Compound)
Methysergide (Compound) resembles Methylergometrine (Compound) and Methylergometrine may cause a moderate interaction that could exacerbate diseases... |
DB00852 | DB09449 | 1,445 | 1,672 | [
"DDInter1545",
"DDInter1691"
] | Pseudoephedrine | Sodium phosphate, monobasic | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Sodium phosphate is a saline laxative that is thought to work by increasing fluid in the small intestine. It usually results in a bowel movement after 30 minutes to 6 hours. | Minor | 0 | [
[
[
1445,
23,
1672
]
],
[
[
1445,
1,
22
],
[
22,
23,
1672
]
],
[
[
1445,
63,
542
],
[
542,
24,
16
],
[
16,
23,
1672
]
],
[
[
1445,
2... | [
[
[
"Pseudoephedrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium phosphate, monobasic"
]
],
[
[
"Pseudoephedrine",
"{u} (Compound) resembles {v} (Compound)",
"Ephedrine"
],
[
"Ephedrine",
"... | Pseudoephedrine (Compound) resembles Ephedrine (Compound) and Ephedrine may cause a minor interaction that can limit clinical effects when taken with Sodium phosphate, monobasic
Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levothyroxine may cause a mo... |
DB00564 | DB09054 | 1,236 | 384 | [
"DDInter293",
"DDInter905"
] | Carbamazepine | Idelalisib | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
1236,
25,
384
]
],
[
[
1236,
24,
222
],
[
222,
23,
384
]
],
[
[
1236,
40,
307
],
[
307,
23,
384
]
],
[
[
1236,
25,
1618
],
[
1618,
... | [
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sib... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Carbamazepine (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can ... |
DB00741 | DB00930 | 167 | 166 | [
"DDInter885",
"DDInter432"
] | Hydrocortisone | Colesevelam | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in th... | Moderate | 1 | [
[
[
167,
24,
166
]
],
[
[
167,
24,
959
],
[
959,
63,
166
]
],
[
[
167,
63,
1645
],
[
1645,
24,
166
]
],
[
[
167,
1,
175
],
[
175,
24... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Colesevelam"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Colesevelam
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Metformin and ... |
DB01229 | DB04845 | 973 | 309 | [
"DDInter1378",
"DDInter1001"
] | Paclitaxel (protein-bound) | Ixabepilone | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
973,
24,
309
]
],
[
[
973,
5,
11579
],
[
11579,
44,
309
]
],
[
[
973,
6,
4161
],
[
4161,
45,
309
]
],
[
[
973,
34,
16974
],
[
16974,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Paclitaxel",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is tre... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone
Paclitaxel (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Ixabepilone (Compound)
Paclitaxel (Compound) binds TUBB3 (Gene) and TUBB3 (Gene) is bound by Ixabepilone (Compound)
Paclit... |
DB00261 | DB01601 | 702 | 833 | [
"DDInter93",
"DDInter1089"
] | Anagrelide | Lopinavir | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to ... | Major | 2 | [
[
[
702,
25,
833
]
],
[
[
702,
25,
1327
],
[
1327,
40,
833
]
],
[
[
702,
6,
7950
],
[
7950,
45,
833
]
],
[
[
702,
24,
752
],
[
752,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lopinavir"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
],
[
"Saquinavir",
"{u} (C... | Anagrelide may lead to a major life threatening interaction when taken with Saquinavir and Saquinavir (Compound) resembles Lopinavir (Compound)
Anagrelide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Lopinavir (Compound)
Anagrelide may cause a moderate interaction that could exacerbate diseases when tak... |
DB00352 | DB01042 | 482 | 1,307 | [
"DDInter1814",
"DDInter1144"
] | Tioguanine | Melphalan | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Moderate | 1 | [
[
[
482,
24,
1307
]
],
[
[
482,
24,
848
],
[
848,
40,
1307
]
],
[
[
482,
5,
11555
],
[
11555,
44,
1307
]
],
[
[
482,
21,
28658
],
[
28658,... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Melphalan (Compound)
Tioguanine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Melphalan (Compound)
Tioguanine (Compound) causes Vomiting... |
DB00674 | DB12245 | 1,516 | 823 | [
"DDInter802",
"DDInter1863"
] | Galantamine | Triclabendazole | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1516,
24,
823
]
],
[
[
1516,
24,
112
],
[
112,
23,
823
]
],
[
[
1516,
63,
1010
],
[
1010,
24,
823
]
],
[
[
1516,
24,
77
],
[
77,
... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
]... | Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine... |
DB00281 | DB01056 | 608 | 571 | [
"DDInter1066",
"DDInter1823"
] | Lidocaine | Tocainide | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | An antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels. | Moderate | 1 | [
[
[
608,
35,
571
]
],
[
[
608,
1,
561
],
[
561,
1,
571
]
],
[
[
608,
25,
490
],
[
490,
1,
571
]
],
[
[
608,
24,
143
],
[
143,
1,
... | [
[
[
"Lidocaine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocainide"
]
],
[
[
"Lidocaine",
"{u} (Compound) resembles {v} (Compound)",
"Levobupivacaine"
],
[
... | Lidocaine (Compound) resembles Tocainide (Compound) and
Lidocaine (Compound) resembles Levobupivacaine (Compound) and Levobupivacaine (Compound) resembles Tocainide (Compound)
Lidocaine may lead to a major life threatening interaction when taken with Prilocaine and Prilocaine (Compound) resembles Tocainide (Compound)
L... |
DB01124 | DB01142 | 1,411 | 1,264 | [
"DDInter1828",
"DDInter593"
] | Tolbutamide | Doxepin | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1411,
24,
1264
]
],
[
[
1411,
63,
508
],
[
508,
24,
1264
]
],
[
[
1411,
6,
6017
],
[
6017,
45,
1264
]
],
[
[
1411,
21,
28852
],
[
2885... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Tolbutamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Doxepin (Compound)
Tolbutamide (Compound) c... |
DB00374 | DB00876 | 1,061 | 1,414 | [
"DDInter1852",
"DDInter658"
] | Treprostinil | Eprosartan | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced. | Moderate | 1 | [
[
[
1061,
24,
1414
]
],
[
[
1061,
24,
240
],
[
240,
40,
1414
]
],
[
[
1061,
6,
6017
],
[
6017,
45,
1414
]
],
[
[
1061,
21,
28957
],
[
2895... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eprosartan"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Losartan"
],
[
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) resembles Eprosartan (Compound)
Treprostinil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Eprosartan (Compound)
Treprostinil (Compound) causes Arthralgia (Side Effect) and Arthra... |
DB01097 | DB06710 | 1,377 | 1,546 | [
"DDInter1033",
"DDInter1193"
] | Leflunomide | Methyltestosterone | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. | Major | 2 | [
[
[
1377,
25,
1546
]
],
[
[
1377,
25,
155
],
[
155,
1,
1546
]
],
[
[
1377,
25,
984
],
[
984,
40,
1546
]
],
[
[
1377,
64,
1026
],
[
1026,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methyltestosterone"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluoxymesterone"
],
[
"Fluoxymest... | Leflunomide may lead to a major life threatening interaction when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Methyltestosterone (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Danazol and Danazol (Compound) resembles Methyltestosterone (Compound)
Leflunom... |
DB00459 | DB01017 | 640 | 1,669 | [
"DDInter21",
"DDInter1224"
] | Acitretin | Minocycline | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Major | 2 | [
[
[
640,
25,
1669
]
],
[
[
640,
25,
1572
],
[
1572,
1,
1669
]
],
[
[
640,
64,
964
],
[
964,
1,
1669
]
],
[
[
640,
25,
1545
],
[
1545,
... | [
[
[
"Acitretin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Minocycline"
]
],
[
[
"Acitretin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Demeclocycline"
],
[
"Demeclocycline",
... | Acitretin may lead to a major life threatening interaction when taken with Demeclocycline and Demeclocycline (Compound) resembles Minocycline (Compound)
Acitretin may lead to a major life threatening interaction when taken with Doxycycline and Doxycycline (Compound) resembles Minocycline (Compound)
Acitretin may lead t... |
DB00851 | DB14761 | 611 | 242 | [
"DDInter463",
"DDInter1578"
] | Dacarbazine | Remdesivir | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
611,
24,
242
]
],
[
[
611,
25,
1377
],
[
1377,
24,
242
]
],
[
[
611,
24,
384
],
[
384,
24,
242
]
],
[
[
611,
63,
482
],
[
482,
2... | [
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Dacarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
],
[
"Lefluno... | Dacarbazine may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may ca... |
DB01041 | DB08865 | 770 | 1,593 | [
"DDInter1789",
"DDInter448"
] | Thalidomide | Crizotinib | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
770,
24,
1593
]
],
[
[
770,
6,
7524
],
[
7524,
45,
1593
]
],
[
[
770,
7,
2900
],
[
2900,
46,
1593
]
],
[
[
770,
7,
5051
],
[
5051,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Thalidomide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)... | Thalidomide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Crizotinib (Compound)
Thalidomide (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Crizotinib (Compound)
Thalidomide (Compound) upregulates SMARCD2 (Gene) and SMARCD2 (Gene) is downregulated by Crizotinib (Compound)
Thalido... |
DB00421 | DB06779 | 443 | 365 | [
"DDInter1707",
"DDInter470"
] | Spironolactone | Dalteparin | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Moderate | 1 | [
[
[
443,
24,
365
]
],
[
[
443,
24,
222
],
[
222,
24,
365
]
],
[
[
443,
24,
738
],
[
738,
63,
365
]
],
[
[
443,
24,
1274
],
[
1274,
2... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalteparin"
]
],
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],... | Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Niraparib a... |
DB00736 | DB08864 | 660 | 786 | [
"DDInter676",
"DDInter1595"
] | Esomeprazole | Rilpivirine | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Major | 2 | [
[
[
660,
25,
786
]
],
[
[
660,
24,
655
],
[
655,
1,
786
]
],
[
[
660,
6,
8374
],
[
8374,
45,
786
]
],
[
[
660,
21,
29343
],
[
29343,
... | [
[
[
"Esomeprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilpivirine"
]
],
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
],
[
"Etrav... | Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Etravirine and Etravirine (Compound) resembles Rilpivirine (Compound)
Esomeprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rilpivirine (Compound)
Esomeprazole (Compound) causes Blood creatinine increased (S... |
DB01281 | DB11988 | 881 | 270 | [
"DDInter5",
"DDInter1321"
] | Abatacept | Ocrelizumab | Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS mo... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
881,
24,
270
]
],
[
[
881,
23,
1193
],
[
1193,
23,
270
]
],
[
[
881,
62,
1461
],
[
1461,
23,
270
]
],
[
[
881,
24,
713
],
[
713,
... | [
[
[
"Abatacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Abatacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
... | Abatacept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Abatacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitami... |
DB06603 | DB15233 | 39 | 1,650 | [
"DDInter1387",
"DDInter142"
] | Panobinostat | Avapritinib | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
39,
25,
1650
]
],
[
[
39,
24,
1478
],
[
1478,
24,
1650
]
],
[
[
39,
64,
1374
],
[
1374,
24,
1650
]
],
[
[
39,
63,
1101
],
[
1101,
... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
"Ivacaf... | Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Panobinostat may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may c... |
DB00802 | DB01176 | 1,322 | 537 | [
"DDInter43",
"DDInter453"
] | Alfentanil | Cyclizine | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1322,
24,
537
]
],
[
[
1322,
24,
1511
],
[
1511,
63,
537
]
],
[
[
1322,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1322,
24,
104
],
[
104,
... | [
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetir... |
DB01344 | DB01396 | 1,231 | 1,482 | [
"DDInter1830",
"DDInter553"
] | Tolevamer | Digitoxin | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Moderate | 1 | [
[
[
1231,
24,
1482
]
],
[
[
1231,
63,
1252
],
[
1252,
1,
1482
]
],
[
[
1231,
25,
1283
],
[
1283,
23,
1482
]
],
[
[
1231,
25,
286
],
[
286,... | [
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
]
],
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
"D... | Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin (Compound) resembles Digitoxin (Compound)
Tolevamer may lead to a major life threatening interaction when taken with Magnesium oxide and Magnesium oxide may cause a minor interaction that can limit clinical eff... |
DB06595 | DB12141 | 1,491 | 971 | [
"DDInter1214",
"DDInter817"
] | Midostaurin | Gilteritinib | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1491,
24,
971
]
],
[
[
1491,
23,
1135
],
[
1135,
23,
971
]
],
[
[
1491,
62,
1247
],
[
1247,
23,
971
]
],
[
[
1491,
63,
485
],
[
485,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Midostaurin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Midostaurin may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Midostaurin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulf... |
DB00563 | DB06372 | 663 | 259 | [
"DDInter1174",
"DDInter1594"
] | Methotrexate | Rilonacept | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
663,
24,
259
]
],
[
[
663,
63,
1461
],
[
1461,
23,
259
]
],
[
[
663,
24,
1619
],
[
1619,
63,
259
]
],
[
[
663,
24,
1573
],
[
1573,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucapar... |
DB01209 | DB09268 | 1,359 | 1,662 | [
"DDInter531",
"DDInter1464"
] | Dezocine | Picosulfuric acid | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1359,
24,
1662
]
],
[
[
1359,
63,
1494
],
[
1494,
24,
1662
]
],
[
[
1359,
40,
234
],
[
234,
24,
1662
]
],
[
[
1359,
64,
475
],
[
475,
... | [
[
[
"Dezocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Dezocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palonosetron"
],
... | Dezocine may cause a moderate interaction that could exacerbate diseases when taken with Palonosetron and Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Dezocine (Compound) resembles Pentazocine (Compound) and Pentazocine may cause a moderate interaction t... |
DB08930 | DB09098 | 1,459 | 98 | [
"DDInter582",
"DDInter1700"
] | Dolutegravir | Somatrem | Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare and ... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Minor | 0 | [
[
[
1459,
23,
98
]
],
[
[
1459,
62,
609
],
[
609,
24,
98
]
],
[
[
1459,
23,
1320
],
[
1320,
63,
98
]
],
[
[
1459,
23,
760
],
[
760,
... | [
[
[
"Dolutegravir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Somatrem"
]
],
[
[
"Dolutegravir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clarithromycin"
],
[
... | Dolutegravir may cause a minor interaction that can limit clinical effects when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Dolutegravir may cause a minor interaction that can limit clinical effects when taken with Elagolix and El... |
DB00795 | DB11986 | 50 | 484 | [
"DDInter1725",
"DDInter648"
] | Sulfasalazine | Entrectinib | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
50,
24,
484
]
],
[
[
50,
24,
466
],
[
466,
62,
484
]
],
[
[
50,
24,
998
],
[
998,
24,
484
]
],
[
[
50,
63,
485
],
[
485,
24,
... | [
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],... | Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazo... |
DB00697 | DB09472 | 876 | 1,383 | [
"DDInter1821",
"DDInter1693"
] | Tizanidine | Sodium sulfate | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
876,
24,
1383
]
],
[
[
876,
24,
609
],
[
609,
24,
1383
]
],
[
[
876,
63,
521
],
[
521,
24,
1383
]
],
[
[
876,
25,
1618
],
[
1618,
... | [
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Tizanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin... |
DB00193 | DB00704 | 534 | 267 | [
"DDInter1841",
"DDInter1263"
] | Tramadol | Naltrexone | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Major | 2 | [
[
[
534,
25,
267
]
],
[
[
534,
24,
173
],
[
173,
1,
267
]
],
[
[
534,
25,
475
],
[
475,
25,
267
]
],
[
[
534,
6,
6291
],
[
6291,
45,... | [
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naltrexone"
]
],
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxone"
],
[
"Naloxone",
... | Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Naloxone and Naloxone (Compound) resembles Naltrexone (Compound)
Tramadol may lead to a major life threatening interaction when taken with Morphine and Morphine may lead to a major life threatening interaction when taken with Naltr... |
DB04865 | DB05015 | 4 | 1,077 | [
"DDInter1335",
"DDInter174"
] | Omacetaxine mepesuccinate | Belinostat | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Moderate | 1 | [
[
[
4,
24,
1077
]
],
[
[
4,
63,
1253
],
[
1253,
24,
1077
]
],
[
[
4,
24,
1136
],
[
1136,
63,
1077
]
],
[
[
4,
25,
292
],
[
292,
63,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belinostat"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Palifermin and Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Belinostat
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when ta... |
DB00530 | DB14723 | 1,195 | 159 | [
"DDInter667",
"DDInter1026"
] | Erlotinib | Larotrectinib | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1195,
24,
159
]
],
[
[
1195,
24,
1375
],
[
1375,
24,
159
]
],
[
[
1195,
23,
307
],
[
307,
24,
159
]
],
[
[
1195,
24,
1412
],
[
1412,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
],
[
... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and Lefamulin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Erlotinib may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil ... |
DB00692 | DB01088 | 274 | 714 | [
"DDInter1448",
"DDInter908"
] | Phentolamine | Iloprost | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
274,
24,
714
]
],
[
[
274,
24,
402
],
[
402,
23,
714
]
],
[
[
274,
24,
1450
],
[
1450,
63,
714
]
],
[
[
274,
24,
1364
],
[
1364,
... | [
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Phentolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tadalafil"
],
[
... | Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Tadalafil and Tadalafil may cause a minor interaction that can limit clinical effects when taken with Iloprost
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empag... |
DB06616 | DB09472 | 594 | 1,383 | [
"DDInter224",
"DDInter1693"
] | Bosutinib | Sodium sulfate | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
594,
24,
1383
]
],
[
[
594,
64,
609
],
[
609,
24,
1383
]
],
[
[
594,
63,
521
],
[
521,
24,
1383
]
],
[
[
594,
24,
1613
],
[
1613,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Clar... | Bosutinib may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin ma... |
DB00427 | DB00964 | 1,233 | 1,617 | [
"DDInter1879",
"DDInter110"
] | Triprolidine | Apraclonidine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. | Moderate | 1 | [
[
[
1233,
24,
1617
]
],
[
[
1233,
24,
1020
],
[
1020,
1,
1617
]
],
[
[
1233,
24,
1084
],
[
1084,
40,
1617
]
],
[
[
1233,
24,
222
],
[
222,... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine (Compound) resembles Apraclonidine (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Lofexidine and Lofexidine (Compound) resembles Apraclonidine (Co... |
DB00379 | DB11767 | 143 | 1,583 | [
"DDInter1206",
"DDInter1643"
] | Mexiletine | Sarilumab | Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
143,
24,
1583
]
],
[
[
143,
63,
58
],
[
58,
24,
1583
]
],
[
[
143,
64,
1031
],
[
1031,
24,
1583
]
],
[
[
143,
24,
1683
],
[
1683,
... | [
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
... | Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Mexiletine may lead to a major life threatening interaction when taken with Theophylline and Theophylline may cause... |
DB01235 | DB09570 | 1,191 | 1,480 | [
"DDInter1054",
"DDInter1002"
] | Levodopa | Ixazomib | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
1191,
24,
1480
]
],
[
[
1191,
63,
268
],
[
268,
24,
1480
]
],
[
[
1191,
24,
148
],
[
148,
63,
1480
]
],
[
[
1191,
24,
310
],
[
310,
... | [
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
],
... | Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Secni... |
DB00773 | DB11828 | 896 | 1,406 | [
"DDInter702",
"DDInter1281"
] | Etoposide | Neratinib | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
896,
24,
1406
]
],
[
[
896,
24,
392
],
[
392,
24,
1406
]
],
[
[
896,
25,
1510
],
[
1510,
24,
1406
]
],
[
[
896,
63,
134
],
[
134,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Etoposide may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause... |
DB01105 | DB01202 | 222 | 1,435 | [
"DDInter1665",
"DDInter1046"
] | Sibutramine | Levetiracetam | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam poss... | Moderate | 1 | [
[
[
222,
24,
1435
]
],
[
[
222,
18,
9385
],
[
9385,
57,
1435
]
],
[
[
222,
21,
28769
],
[
28769,
60,
1435
]
],
[
[
222,
63,
701
],
[
701,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levetiracetam"
]
],
[
[
"Sibutramine",
"{u} (Compound) downregulates {v} (Gene)",
"MRPL19"
],
[
"MRPL19",
"{u} (Gene) is downregulate... | Sibutramine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Levetiracetam (Compound)
Sibutramine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Levetiracetam (Compound)
Sibutramine may cause a moderate interaction that could exacerbate disea... |
DB00812 | DB06779 | 998 | 365 | [
"DDInter1451",
"DDInter470"
] | Phenylbutazone | Dalteparin | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
998,
25,
365
]
],
[
[
998,
63,
305
],
[
305,
24,
365
]
],
[
[
998,
24,
222
],
[
222,
24,
365
]
],
[
[
998,
24,
738
],
[
738,
63,... | [
[
[
"Phenylbutazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia coli"
... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Phenylbutazone may cause a moderate interaction that could exacerbate ... |
DB00827 | DB14520 | 646 | 1,229 | [
"DDInter383",
"DDInter1785"
] | Cinoxacin | Tetraferric tricitrate decahydrate | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Tetraferric tricitrate decahydrate is an iron containing phosphate binder used to treat hyperphosphatemia and iron deficiency anemia in adults with chronic kidney disease. Tetraferric tricitrate decahydrate was granted FDA approval on 5 September 2014. | Moderate | 1 | [
[
[
646,
24,
1229
]
],
[
[
646,
24,
1096
],
[
1096,
23,
1229
]
],
[
[
646,
21,
28722
],
[
28722,
60,
955
],
[
955,
23,
1229
]
],
[
[
646,
... | [
[
[
"Cinoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetraferric tricitrate decahydrate"
]
],
[
[
"Cinoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycop... | Cinoxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Tetraferric tricitrate decahydrate
Cinoxacin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is ... |
DB01278 | DB04865 | 1,021 | 4 | [
"DDInter1506",
"DDInter1335"
] | Pramlintide | Omacetaxine mepesuccinate | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1021,
24,
4
]
],
[
[
1021,
63,
485
],
[
485,
24,
4
]
],
[
[
1021,
24,
1616
],
[
1616,
63,
4
]
],
[
[
1021,
24,
1254
],
[
1254,
2... | [
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidin... | Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Hi... |
DB00331 | DB01406 | 1,645 | 984 | [
"DDInter1164",
"DDInter472"
] | Metformin | Danazol | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Moderate | 1 | [
[
[
1645,
24,
984
]
],
[
[
1645,
24,
989
],
[
989,
1,
984
]
],
[
[
1645,
63,
1657
],
[
1657,
1,
984
]
],
[
[
1645,
63,
1336
],
[
1336,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danazol"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Progesterone"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Progesterone and Progesterone (Compound) resembles Danazol (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Desogestrel and Desogestrel (Compound) resembles Danazol (Compound)
Me... |
DB00039 | DB01229 | 1,253 | 973 | [
"DDInter1380",
"DDInter1377"
] | Palifermin | Paclitaxel | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
1253,
24,
973
]
],
[
[
1253,
24,
310
],
[
310,
63,
973
]
],
[
[
1253,
24,
134
],
[
134,
24,
973
]
],
[
[
1253,
63,
491
],
[
491,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vin... |
DB00641 | DB11967 | 467 | 710 | [
"DDInter1675",
"DDInter210"
] | Simvastatin | Binimetinib | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
467,
24,
710
]
],
[
[
467,
25,
441
],
[
441,
24,
710
]
],
[
[
467,
24,
1593
],
[
1593,
24,
710
]
],
[
[
467,
25,
68
],
[
68,
63,... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Delavirdine"
],
[
"Delavi... | Simvastatin may lead to a major life threatening interaction when taken with Delavirdine and Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may c... |
DB01138 | DB04865 | 804 | 4 | [
"DDInter1726",
"DDInter1335"
] | Sulfinpyrazone | Omacetaxine mepesuccinate | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Major | 2 | [
[
[
804,
25,
4
]
],
[
[
804,
24,
1250
],
[
1250,
63,
4
]
],
[
[
804,
63,
995
],
[
995,
24,
4
]
],
[
[
804,
24,
973
],
[
973,
24,
... | [
[
[
"Sulfinpyrazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
],
... | Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB08912 | DB11837 | 1,040 | 1,297 | [
"DDInter462",
"DDInter1351"
] | Dabrafenib | Osilodrostat | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1040,
24,
1297
]
],
[
[
1040,
24,
1135
],
[
1135,
23,
1297
]
],
[
[
1040,
63,
1247
],
[
1247,
23,
1297
]
],
[
[
1040,
24,
466
],
[
466... | [
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Su... |
DB00539 | DB13074 | 11 | 877 | [
"DDInter1837",
"DDInter1110"
] | Toremifene | Macimorelin | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
11,
25,
877
]
],
[
[
11,
23,
112
],
[
112,
23,
877
]
],
[
[
11,
24,
1320
],
[
1320,
24,
877
]
],
[
[
11,
25,
651
],
[
651,
24,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Toremifene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Toremifene may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elago... |
DB00252 | DB00445 | 362 | 322 | [
"DDInter1460",
"DDInter655"
] | Phenytoin | Epirubicin | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
362,
24,
322
]
],
[
[
362,
7,
6952
],
[
6952,
46,
322
]
],
[
[
362,
21,
28949
],
[
28949,
60,
322
]
],
[
[
362,
24,
112
],
[
112,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Phenytoin",
"{u} (Compound) upregulates {v} (Gene)",
"MCOLN1"
],
[
"MCOLN1",
"{u} (Gene) is upregulated by {v} (C... | Phenytoin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Epirubicin (Compound)
Phenytoin (Compound) causes Haemoptysis (Side Effect) and Haemoptysis (Side Effect) is caused by Epirubicin (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Metron... |
DB00443 | DB00876 | 251 | 1,414 | [
"DDInter195",
"DDInter658"
] | Betamethasone | Eprosartan | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced. | Moderate | 1 | [
[
[
251,
24,
1414
]
],
[
[
251,
24,
240
],
[
240,
40,
1414
]
],
[
[
251,
21,
29291
],
[
29291,
60,
1414
]
],
[
[
251,
63,
176
],
[
176,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eprosartan"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Losartan"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) resembles Eprosartan (Compound)
Betamethasone (Compound) causes Muscular weakness (Side Effect) and Muscular weakness (Side Effect) is caused by Eprosartan (Compound)
Betamethasone may cause a ... |
DB05812 | DB06663 | 1,374 | 1,154 | [
"DDInter8",
"DDInter1398"
] | Abiraterone | Pasireotide | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
1374,
25,
1154
]
],
[
[
1374,
21,
29477
],
[
29477,
60,
1154
]
],
[
[
1374,
62,
112
],
[
112,
23,
1154
]
],
[
[
1374,
23,
907
],
[
907... | [
[
[
"Abiraterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Abiraterone",
"{u} (Compound) causes {v} (Side Effect)",
"Hypercholesterolaemia"
],
[
"Hypercholesterolaemia",
"{u} (Side Eff... | Abiraterone (Compound) causes Hypercholesterolaemia (Side Effect) and Hypercholesterolaemia (Side Effect) is caused by Pasireotide (Compound)
Abiraterone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical ef... |
DB01242 | DB11095 | 1,237 | 235 | [
"DDInter410",
"DDInter505"
] | Clomipramine | Desirudin | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Moderate | 1 | [
[
[
1237,
24,
235
]
],
[
[
1237,
24,
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],
[
1151,
24,
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]
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[
[
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],
[
885,
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235
]
],
[
[
1237,
64,
1039
],
[
1039,
... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desirudin"
]
],
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
],
[
... | Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epo... |
DB06402 | DB06603 | 1,079 | 39 | [
"DDInter1756",
"DDInter1387"
] | Telavancin | Panobinostat | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1079,
25,
39
]
],
[
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1079,
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],
[
112,
23,
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[
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1079,
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455
],
[
455,
24,
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]
],
[
[
1079,
24,
720
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[
720,
63... | [
[
[
"Telavancin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Telavancin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Telavancin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Sa... |
DB01592 | DB15617 | 1,596 | 174 | [
"DDInter975",
"DDInter724"
] | Iron | Ferric derisomaltose | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Iron deficiency is an extremely common condition and is the most frequent cause of anemia worldwide. Iron deficiency results when iron intake, iron stores, and loss of iron from the body do not adequately support production of erythrocytes, also known as red blood cells. Though it is generally considered non life-threa... | Moderate | 1 | [
[
[
1596,
24,
174
]
],
[
[
1596,
63,
597
],
[
597,
24,
174
]
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[
[
1596,
25,
1575
],
[
1575,
25,
174
]
],
[
[
1596,
63,
597
],
[
597,
... | [
[
[
"Iron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferric derisomaltose"
]
],
[
[
"Iron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
],
[... | Iron may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Ferric derisomaltose
Iron may lead to a major life threatening interaction when taken with Dimercaprol and Dimercaprol ... |
DB01267 | DB06603 | 519 | 39 | [
"DDInter1381",
"DDInter1387"
] | Paliperidone | Panobinostat | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
519,
25,
39
]
],
[
[
519,
62,
112
],
[
112,
23,
39
]
],
[
[
519,
63,
272
],
[
272,
24,
39
]
],
[
[
519,
24,
720
],
[
720,
63,
... | [
[
[
"Paliperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Paliperidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Paliperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniram... |
DB00443 | DB01132 | 251 | 1,130 | [
"DDInter195",
"DDInter1472"
] | Betamethasone | Pioglitazone | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
251,
24,
1130
]
],
[
[
251,
6,
8374
],
[
8374,
45,
1130
]
],
[
[
251,
7,
4698
],
[
4698,
46,
1130
]
],
[
[
251,
18,
5057
],
[
5057,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Betamethasone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Com... | Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pioglitazone (Compound)
Betamethasone (Compound) upregulates GPC1 (Gene) and GPC1 (Gene) is upregulated by Pioglitazone (Compound)
Betamethasone (Compound) downregulates IL1B (Gene) and IL1B (Gene) is upregulated by Pioglitazone (Compound)
Betam... |
DB03904 | DB09020 | 1,574 | 28 | [
"DDInter1903",
"DDInter212"
] | Urea | Bisacodyl | A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1574,
24,
28
]
],
[
[
1574,
63,
355
],
[
355,
24,
28
]
],
[
[
1574,
24,
286
],
[
286,
63,
28
]
],
[
[
1574,
63,
355
],
[
355,
54... | [
[
[
"Urea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Urea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
],
[
"Lactulose... | Urea may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Urea may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hy... |
DB00065 | DB00281 | 581 | 608 | [
"DDInter923",
"DDInter1066"
] | Infliximab | Lidocaine | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anes... | Moderate | 1 | [
[
[
581,
24,
608
]
],
[
[
581,
25,
1101
],
[
1101,
62,
608
]
],
[
[
581,
24,
208
],
[
208,
62,
608
]
],
[
[
581,
24,
362
],
[
362,
2... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarotene"... | Infliximab may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lidocaine
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Mephenytoin and Mephenytoin may cause a... |
DB12035 | DB12364 | 943 | 1,421 | [
"DDInter1641",
"DDInter200"
] | Sarecycline | Betrixaban | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007. After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe ... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
943,
24,
1421
]
],
[
[
943,
63,
1513
],
[
1513,
24,
1421
]
],
[
[
943,
24,
971
],
[
971,
24,
1421
]
],
[
[
943,
63,
392
],
[
392,
... | [
[
[
"Sarecycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Sarecycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apremilast"
],
[
... | Sarecycline may cause a moderate interaction that could exacerbate diseases when taken with Apremilast and Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Sarecycline may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gi... |
DB11689 | DB12267 | 321 | 1,476 | [
"DDInter1659",
"DDInter233"
] | Selumetinib | Brigatinib | Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating ea... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
321,
24,
1476
]
],
[
[
321,
63,
951
],
[
951,
24,
1476
]
],
[
[
321,
24,
1421
],
[
1421,
63,
1476
]
],
[
[
321,
24,
1297
],
[
1297,
... | [
[
[
"Selumetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Selumetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
],
[... | Selumetinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Selumetinib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban and Be... |
DB11071 | DB11921 | 1,004 | 1,019 | [
"DDInter1449",
"DDInter492"
] | Phenyl salicylate | Deflazacort | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1004,
24,
1019
]
],
[
[
1004,
63,
959
],
[
959,
24,
1019
]
],
[
[
1004,
24,
877
],
[
877,
63,
1019
]
],
[
[
1004,
63,
1220
],
[
1220,
... | [
[
[
"Phenyl salicylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Phenyl salicylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
... | Phenyl salicylate may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Phenyl salicylate may cause a moderate interaction that could exacerbate diseases when taken with Macimore... |
DB00005 | DB00762 | 1,057 | 613 | [
"DDInter687",
"DDInter973"
] | Etanercept | Irinotecan | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Major | 2 | [
[
[
1057,
25,
613
]
],
[
[
1057,
25,
869
],
[
869,
63,
613
]
],
[
[
1057,
24,
599
],
[
599,
24,
613
]
],
[
[
1057,
25,
1555
],
[
1555,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Irinotecan"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Topotecan"
],
[
"Topotecan",
"{u} may... | Etanercept may lead to a major life threatening interaction when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause ... |
DB00468 | DB08826 | 1,424 | 1,292 | [
"DDInter1557",
"DDInter489"
] | Quinine | Deferiprone | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
1424,
25,
1292
]
],
[
[
1424,
21,
28809
],
[
28809,
60,
1292
]
],
[
[
1424,
24,
1017
],
[
1017,
63,
1292
]
],
[
[
1424,
63,
1101
],
[
... | [
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Quinine",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) is caused by {v} (Compound)... | Quinine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Deferiprone (Compound)
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
... |
DB01128 | DB01242 | 918 | 1,237 | [
"DDInter204",
"DDInter410"
] | Bicalutamide | Clomipramine | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
918,
24,
1237
]
],
[
[
918,
64,
684
],
[
684,
1,
1237
]
],
[
[
918,
63,
1164
],
[
1164,
1,
1237
]
],
[
[
918,
63,
401
],
[
401,
... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Bicalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
"Th... | Bicalutamide may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (Compound)... |
DB01232 | DB05294 | 1,327 | 1,069 | [
"DDInter1640",
"DDInter1917"
] | Saquinavir | Vandetanib | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
1327,
25,
1069
]
],
[
[
1327,
63,
1195
],
[
1195,
40,
1069
]
],
[
[
1327,
6,
17404
],
[
17404,
45,
1069
]
],
[
[
1327,
21,
29343
],
[
... | [
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
],
[
"Erlotinib",... | Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib (Compound) resembles Vandetanib (Compound)
Saquinavir (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Vandetanib (Compound)
Saquinavir (Compound) causes Blood creatinine increased (Side Effect) ... |
DB06081 | DB08918 | 1,046 | 41 | [
"DDInter286",
"DDInter1059"
] | Caplacizumab | Levomilnacipran | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
1046,
24,
41
]
],
[
[
1046,
63,
901
],
[
901,
40,
41
]
],
[
[
1046,
25,
498
],
[
498,
63,
41
]
],
[
[
1046,
64,
330
],
[
330,
24... | [
[
[
"Caplacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Caplacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]... | Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Caplacizumab may lead to a major life threatening interaction when taken with Edoxaban and Edoxaban may cause a moderate interaction that could exacerb... |
DB00912 | DB06414 | 473 | 655 | [
"DDInter1581",
"DDInter703"
] | Repaglinide | Etravirine | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
473,
24,
655
]
],
[
[
473,
6,
8374
],
[
8374,
45,
655
]
],
[
[
473,
21,
28723
],
[
28723,
60,
655
]
],
[
[
473,
63,
1101
],
[
1101,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Repaglinide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Repaglinide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Etravirine (Compound)
Repaglinide (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Etravirine (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene... |
DB00398 | DB05294 | 79 | 1,069 | [
"DDInter1702",
"DDInter1917"
] | Sorafenib | Vandetanib | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
79,
25,
1069
]
],
[
[
79,
24,
1195
],
[
1195,
40,
1069
]
],
[
[
79,
5,
11648
],
[
11648,
44,
1069
]
],
[
[
79,
6,
17404
],
[
17404,
... | [
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
],
[
"Erlotinib",
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib (Compound) resembles Vandetanib (Compound)
Sorafenib (Compound) treats thyroid cancer (Disease) and thyroid cancer (Disease) is treated by Vandetanib (Compound)
Sorafenib (Compound) binds ABCG2 (Gene) and A... |
DB00794 | DB13074 | 759 | 877 | [
"DDInter1521",
"DDInter1110"
] | Primidone | Macimorelin | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
759,
24,
877
]
],
[
[
759,
24,
112
],
[
112,
23,
877
]
],
[
[
759,
24,
1320
],
[
1320,
24,
877
]
],
[
[
759,
25,
1019
],
[
1019,
... | [
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Primidone may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elago... |
DB06772 | DB09115 | 310 | 505 | [
"DDInter259",
"DDInter559"
] | Cabazitaxel | Diiodohydroxyquinoline | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
310,
24,
505
]
],
[
[
310,
24,
1593
],
[
1593,
24,
505
]
],
[
[
310,
63,
467
],
[
467,
24,
505
]
],
[
[
310,
64,
908
],
[
908,
2... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Simvast... |
DB00607 | DB13074 | 1,249 | 877 | [
"DDInter1256",
"DDInter1110"
] | Nafcillin | Macimorelin | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
1249,
24,
877
]
],
[
[
1249,
24,
1320
],
[
1320,
24,
877
]
],
[
[
1249,
25,
1019
],
[
1019,
24,
877
]
],
[
[
1249,
62,
1101
],
[
1101,... | [
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
],
[
... | Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin
Nafcillin may lead to a major life threatening interaction when taken with Deflazacort and Deflazacort may cause a m... |
DB00451 | DB08882 | 542 | 1,281 | [
"DDInter1064",
"DDInter1070"
] | Levothyroxine | Linagliptin | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
542,
24,
1281
]
],
[
[
542,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
542,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
542,
21,
29081
],
[
29081,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Levothyroxine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Levothyroxine (Compound) causes Angioedema (Side Effect) a... |
DB01118 | DB08899 | 33 | 129 | [
"DDInter76",
"DDInter649"
] | Amiodarone | Enzalutamide | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
33,
25,
129
]
],
[
[
33,
25,
918
],
[
918,
1,
129
]
],
[
[
33,
6,
8374
],
[
8374,
45,
129
]
],
[
[
33,
21,
28703
],
[
28703,
60,... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
],
[
"Bicalutamide",
... | Amiodarone may lead to a major life threatening interaction when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Amiodarone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Amiodarone (Compound) causes Pruritus (Side Effect) and Pruritus (Side Ef... |
DB01105 | DB03904 | 222 | 1,574 | [
"DDInter1665",
"DDInter1903"
] | Sibutramine | Urea | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | Moderate | 1 | [
[
[
222,
24,
1574
]
],
[
[
222,
25,
1399
],
[
1399,
62,
1574
]
],
[
[
222,
25,
643
],
[
643,
63,
1574
]
],
[
[
222,
64,
1230
],
[
1230,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Urea"
]
],
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lithium carbonate"
],
[
"Lithium... | Sibutramine may lead to a major life threatening interaction when taken with Lithium carbonate and Lithium carbonate may cause a minor interaction that can limit clinical effects when taken with Urea
Sibutramine may lead to a major life threatening interaction when taken with Desvenlafaxine and Desvenlafaxine may cause... |
DB00446 | DB15035 | 597 | 503 | [
"DDInter351",
"DDInter1959"
] | Chloramphenicol | Zanubrutinib | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Moderate | 1 | [
[
[
597,
24,
503
]
],
[
[
597,
24,
810
],
[
810,
24,
503
]
],
[
[
597,
25,
1478
],
[
1478,
24,
503
]
],
[
[
597,
63,
599
],
[
599,
2... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chlor... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89 and Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Chloramphenicol may lead to a major life threatening interaction when taken w... |
DB01037 | DB09241 | 1,161 | 1,629 | [
"DDInter1653",
"DDInter1186"
] | Selegiline | Methylene blue | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1161,
25,
1629
]
],
[
[
1161,
24,
1148
],
[
1148,
24,
1629
]
],
[
[
1161,
63,
1674
],
[
1674,
24,
1629
]
],
[
[
1161,
75,
73
],
[
73,
... | [
[
[
"Selegiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Selegiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
"Isop... | Selegiline may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Selegiline may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline... |
DB01197 | DB06779 | 1,603 | 365 | [
"DDInter292",
"DDInter470"
] | Captopril | Dalteparin | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Moderate | 1 | [
[
[
1603,
24,
365
]
],
[
[
1603,
63,
305
],
[
305,
24,
365
]
],
[
[
1603,
40,
610
],
[
610,
24,
365
]
],
[
[
1603,
63,
1274
],
[
1274,
... | [
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalteparin"
]
],
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia coli... | Captopril may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Captopril (Compound) resembles Enalapril (Compound) and Enalapril may cause... |
DB00227 | DB11989 | 1,463 | 1,434 | [
"DDInter1098",
"DDInter183"
] | Lovastatin | Benznidazole | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
1463,
24,
1434
]
],
[
[
1463,
24,
375
],
[
375,
24,
1434
]
],
[
[
1463,
24,
148
],
[
148,
63,
1434
]
],
[
[
1463,
63,
581
],
[
581,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol and Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Sec... |
DB00912 | DB01320 | 473 | 651 | [
"DDInter1581",
"DDInter783"
] | Repaglinide | Fosphenytoin | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
473,
24,
651
]
],
[
[
473,
63,
307
],
[
307,
1,
651
]
],
[
[
473,
6,
1829
],
[
1829,
45,
651
]
],
[
[
473,
21,
28784
],
[
28784,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil (Compound) resembles Fosphenytoin (Compound)
Repaglinide (Compound) binds ALB (Gene) and ALB (Gene) is bound by Fosphenytoin (Compound)
Repaglinide (Compound) causes Thrombocytopenia (Side Effect) and Thr... |
DB00531 | DB08868 | 450 | 1,011 | [
"DDInter456",
"DDInter737"
] | Cyclophosphamide | Fingolimod | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
450,
25,
1011
]
],
[
[
450,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
450,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
450,
24,
112
],
[
112,... | [
[
[
"Cyclophosphamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Cyclophosphamide",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Cyclophosphamide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Cyclophosphamide (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when ta... |
DB00014 | DB01059 | 521 | 956 | [
"DDInter839",
"DDInter1313"
] | Goserelin | Norfloxacin | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Moderate | 1 | [
[
[
521,
24,
956
]
],
[
[
521,
24,
872
],
[
872,
40,
956
]
],
[
[
521,
25,
1176
],
[
1176,
1,
956
]
],
[
[
521,
24,
1539
],
[
1539,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
],
[
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Goserelin may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (Compound)
Goserel... |
DB00530 | DB00631 | 1,195 | 372 | [
"DDInter667",
"DDInter405"
] | Erlotinib | Clofarabine | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
1195,
24,
372
]
],
[
[
1195,
6,
17404
],
[
17404,
45,
372
]
],
[
[
1195,
7,
9900
],
[
9900,
46,
372
]
],
[
[
1195,
18,
3222
],
[
3222,... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Erlotinib",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)",
... | Erlotinib (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Clofarabine (Compound)
Erlotinib (Compound) upregulates SLC1A4 (Gene) and SLC1A4 (Gene) is upregulated by Clofarabine (Compound)
Erlotinib (Compound) downregulates DUSP4 (Gene) and DUSP4 (Gene) is upregulated by Clofarabine (Compound)
Erlotinib (Compo... |
DB00439 | DB00619 | 289 | 1,419 | [
"DDInter341",
"DDInter909"
] | Cerivastatin | Imatinib | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
289,
24,
1419
]
],
[
[
289,
24,
309
],
[
309,
63,
1419
]
],
[
[
289,
63,
305
],
[
305,
24,
1419
]
],
[
[
289,
24,
1555
],
[
1555,
... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
[... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Imatinib
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Esch... |
DB00584 | DB08894 | 610 | 1,126 | [
"DDInter638",
"DDInter1406"
] | Enalapril | Peginesatide | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of th... | Minor | 0 | [
[
[
610,
23,
1126
]
],
[
[
610,
1,
1058
],
[
1058,
23,
1126
]
],
[
[
610,
40,
1638
],
[
1638,
23,
1126
]
],
[
[
610,
1,
1058
],
[
1058,
... | [
[
[
"Enalapril",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Peginesatide"
]
],
[
[
"Enalapril",
"{u} (Compound) resembles {v} (Compound)",
"Moexipril"
],
[
"Moexipril",
"{u} may cause a minor inter... | Enalapril (Compound) resembles Moexipril (Compound) and Moexipril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Enalapril (Compound) resembles Trandolapril (Compound) and Trandolapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
... |
DB00612 | DB01285 | 1,121 | 708 | [
"DDInter216",
"DDInter445"
] | Bisoprolol | Corticotropin | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
1121,
24,
708
]
],
[
[
1121,
24,
455
],
[
455,
23,
708
]
],
[
[
1121,
24,
659
],
[
659,
62,
708
]
],
[
[
1121,
63,
245
],
[
245,
... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Corticotropin
Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilan... |
DB01021 | DB01240 | 674 | 885 | [
"DDInter1861",
"DDInter657"
] | Trichlormethiazide | Epoprostenol | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
674,
24,
885
]
],
[
[
674,
63,
1061
],
[
1061,
1,
885
]
],
[
[
674,
63,
1512
],
[
1512,
24,
885
]
],
[
[
674,
24,
1450
],
[
1450,
... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprosti... | Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate ... |
DB05812 | DB08886 | 1,374 | 637 | [
"DDInter8",
"DDInter126"
] | Abiraterone | Asparaginase Erwinia chrysanthemi | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
1374,
24,
637
]
],
[
[
1374,
63,
392
],
[
392,
24,
637
]
],
[
[
1374,
24,
850
],
[
850,
24,
637
]
],
[
[
1374,
24,
159
],
[
159,
... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"La... | Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Abiraterone may cause a moderate interaction that could exacerbate diseases when taken wit... |
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