drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01404 | DB06228 | 757 | 792 | [
"DDInter820",
"DDInter1609"
] | Ginseng | Rivaroxaban | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
757,
24,
792
]
],
[
[
757,
63,
1324
],
[
1324,
24,
792
]
],
[
[
757,
64,
1419
],
[
1419,
24,
792
]
],
[
[
757,
63,
25
],
[
25,
2... | [
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[
... | Ginseng may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban
Ginseng may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a mod... |
DB00814 | DB09472 | 1,171 | 1,383 | [
"DDInter1143",
"DDInter1693"
] | Meloxicam | Sodium sulfate | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1171,
24,
1383
]
],
[
[
1171,
63,
600
],
[
600,
24,
1383
]
],
[
[
1171,
24,
1613
],
[
1613,
24,
1383
]
],
[
[
1171,
25,
1618
],
[
1618... | [
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[... | Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon bet... |
DB00317 | DB00418 | 883 | 536 | [
"DDInter810",
"DDInter1650"
] | Gefitinib | Secobarbital | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Moderate | 1 | [
[
[
883,
24,
536
]
],
[
[
883,
63,
1023
],
[
1023,
1,
536
]
],
[
[
883,
24,
697
],
[
697,
1,
536
]
],
[
[
883,
6,
6017
],
[
6017,
45... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentobarbital"
],
[... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital and Pentobarbital (Compound) resembles Secobarbital (Compound)
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Secobarbit... |
DB04837 | DB06282 | 649 | 516 | [
"DDInter407",
"DDInter1053"
] | Clofedanol | Levocetirizine | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
649,
24,
516
]
],
[
[
649,
63,
701
],
[
701,
24,
516
]
],
[
[
649,
24,
1293
],
[
1293,
63,
516
]
],
[
[
649,
1,
1301
],
[
1301,
... | [
[
[
"Clofedanol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Clofedanol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine and V... |
DB11652 | DB12364 | 1,155 | 1,421 | [
"DDInter1891",
"DDInter200"
] | Tucatinib | Betrixaban | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
1155,
24,
1421
]
],
[
[
1155,
63,
1513
],
[
1513,
24,
1421
]
],
[
[
1155,
25,
1017
],
[
1017,
24,
1421
]
],
[
[
1155,
24,
214
],
[
214... | [
[
[
"Tucatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Tucatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apremilast"
],
[
... | Tucatinib may cause a moderate interaction that could exacerbate diseases when taken with Apremilast and Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Tucatinib may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may cause a ... |
DB00434 | DB00555 | 13 | 706 | [
"DDInter459",
"DDInter1020"
] | Cyproheptadine | Lamotrigine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It... | Moderate | 1 | [
[
[
13,
24,
706
]
],
[
[
13,
6,
16431
],
[
16431,
45,
706
]
],
[
[
13,
10,
11584
],
[
11584,
49,
706
]
],
[
[
13,
21,
28662
],
[
28662,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lamotrigine"
]
],
[
[
"Cyproheptadine",
"{u} (Compound) binds {v} (Gene)",
"UGT1A3"
],
[
"UGT1A3",
"{u} (Gene) is bound by {v} (Co... | Cyproheptadine (Compound) binds UGT1A3 (Gene) and UGT1A3 (Gene) is bound by Lamotrigine (Compound)
Cyproheptadine (Compound) palliates schizophrenia (Disease) and schizophrenia (Disease) is palliated by Lamotrigine (Compound)
Cyproheptadine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by La... |
DB00915 | DB01142 | 1,170 | 1,264 | [
"DDInter60",
"DDInter593"
] | Amantadine | Doxepin | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesi... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1170,
24,
1264
]
],
[
[
1170,
24,
401
],
[
401,
24,
1264
]
],
[
[
1170,
63,
832
],
[
832,
24,
1264
]
],
[
[
1170,
6,
4973
],
[
4973,
... | [
[
[
"Amantadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Amantadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and T... |
DB00241 | DB00959 | 288 | 1,486 | [
"DDInter257",
"DDInter1191"
] | Butalbital | Methylprednisolone | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
288,
24,
1486
]
],
[
[
288,
24,
175
],
[
175,
40,
1486
]
],
[
[
288,
24,
167
],
[
167,
1,
1486
]
],
[
[
288,
24,
1344
],
[
1344,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles ... |
DB01149 | DB06616 | 851 | 594 | [
"DDInter1274",
"DDInter224"
] | Nefazodone | Bosutinib | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
851,
25,
594
]
],
[
[
851,
63,
883
],
[
883,
1,
594
]
],
[
[
851,
6,
8374
],
[
8374,
45,
594
]
],
[
[
851,
7,
3218
],
[
3218,
45... | [
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"Gefitinib",
... | Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Nefazodone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Nefazodone (Compound) upregulates IKBKE (Gene) and IKBKE (Gene) is bou... |
DB01156 | DB01324 | 593 | 178 | [
"DDInter252",
"DDInter1490"
] | Bupropion | Polythiazide | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
593,
24,
178
]
],
[
[
593,
63,
674
],
[
674,
40,
178
]
],
[
[
593,
21,
28835
],
[
28835,
60,
178
]
],
[
[
593,
63,
126
],
[
126,
... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
],
... | Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Bupropion (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Polythiazide (Compound)
Bupropion may ca... |
DB00011 | DB00649 | 1,451 | 231 | [
"DDInter944",
"DDInter1710"
] | Interferon alfa-n1 | Stavudine | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Moderate | 1 | [
[
[
1451,
24,
231
]
],
[
[
1451,
25,
1477
],
[
1477,
40,
231
]
],
[
[
1451,
25,
139
],
[
139,
1,
231
]
],
[
[
1451,
24,
375
],
[
375,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stavudine"
]
],
[
[
"Interferon alfa-n1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telbivudine"
],
[
... | Interferon alfa-n1 may lead to a major life threatening interaction when taken with Telbivudine and Telbivudine (Compound) resembles Stavudine (Compound)
Interferon alfa-n1 may lead to a major life threatening interaction when taken with Zidovudine and Zidovudine (Compound) resembles Stavudine (Compound)
Interferon alf... |
DB00344 | DB00889 | 1,302 | 1,133 | [
"DDInter1543",
"DDInter840"
] | Protriptyline | Granisetron | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Major | 2 | [
[
[
1302,
25,
1133
]
],
[
[
1302,
24,
19
],
[
19,
40,
1133
]
],
[
[
1302,
24,
85
],
[
85,
1,
1133
]
],
[
[
1302,
6,
12523
],
[
12523,
... | [
[
[
"Protriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Granisetron"
]
],
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hy... | Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Granisetron (Compound)
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Granisetron (Comp... |
DB00247 | DB11837 | 1,131 | 1,297 | [
"DDInter1194",
"DDInter1351"
] | Methysergide | Osilodrostat | An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize sero... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1131,
24,
1297
]
],
[
[
1131,
24,
222
],
[
222,
23,
1297
]
],
[
[
1131,
24,
1320
],
[
1320,
63,
1297
]
],
[
[
1131,
24,
353
],
[
353,
... | [
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Methysergide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Methysergide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Methysergide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and El... |
DB00801 | DB09293 | 1,563 | 116 | [
"DDInter850",
"DDInter954"
] | Halazepam | Iodide I-131 | Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.[A1212, A178114] It has been shown to be less toxic than chlordiazepoxide or diazepam. This drug is no longer marketed in the United States, and was withdrawn by _Schering_, its manufacturer, in 2009... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
1563,
24,
116
]
],
[
[
1563,
63,
701
],
[
701,
24,
116
]
],
[
[
1563,
24,
516
],
[
516,
24,
116
]
],
[
[
1563,
40,
1418
],
[
1418,
... | [
[
[
"Halazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Halazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Halazepam may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Halazepam may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and Le... |
DB00668 | DB01267 | 874 | 519 | [
"DDInter652",
"DDInter1381"
] | Epinephrine | Paliperidone | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
874,
24,
519
]
],
[
[
874,
24,
1664
],
[
1664,
1,
519
]
],
[
[
874,
6,
5299
],
[
5299,
45,
519
]
],
[
[
874,
21,
28658
],
[
28658,
... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Epinephrine (Compound) binds ADRA2C (Gene) and ADRA2C (Gene) is bound by Paliperidone (Compound)
Epinephrine (Compound) causes Vomiting (Side Effect) and V... |
DB00047 | DB00691 | 176 | 1,058 | [
"DDInter932",
"DDInter1237"
] | Insulin glargine | Moexipril | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Moderate | 1 | [
[
[
176,
24,
1058
]
],
[
[
176,
24,
1638
],
[
1638,
1,
1058
]
],
[
[
176,
24,
954
],
[
954,
40,
1058
]
],
[
[
176,
24,
175
],
[
175,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Moexipril"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Moexipril (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Moexipril... |
DB00559 | DB00604 | 152 | 1,425 | [
"DDInter223",
"DDInter385"
] | Bosentan | Cisapride | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Moderate | 1 | [
[
[
152,
24,
1425
]
],
[
[
152,
63,
883
],
[
883,
1,
1425
]
],
[
[
152,
6,
6017
],
[
6017,
45,
1425
]
],
[
[
152,
24,
112
],
[
112,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisapride"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"G... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Cisapride (Compound)
Bosentan (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Cisapride (Compound)
Bosentan may cause a moderate interaction that could exacerbate diseases w... |
DB05578 | DB06779 | 330 | 365 | [
"DDInter1566",
"DDInter470"
] | Ramucirumab | Dalteparin | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
330,
25,
365
]
],
[
[
330,
63,
1100
],
[
1100,
24,
365
]
],
[
[
330,
24,
1427
],
[
1427,
63,
365
]
],
[
[
330,
25,
1004
],
[
1004,
... | [
[
[
"Ramucirumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Ramucirumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
],
[
"Venlafa... | Ramucirumab may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Ramucirumab may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine and ... |
DB08880 | DB08895 | 1,510 | 976 | [
"DDInter1771",
"DDInter1825"
] | Teriflunomide | Tofacitinib | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
1510,
25,
976
]
],
[
[
1510,
23,
1193
],
[
1193,
62,
976
]
],
[
[
1510,
62,
1461
],
[
1461,
23,
976
]
],
[
[
1510,
25,
214
],
[
214,
... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Teriflunomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Z... | Teriflunomide may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Teriflunomide may cause a minor interaction that can limit clinical effects when taken with Vitamin E an... |
DB00377 | DB00818 | 1,494 | 898 | [
"DDInter1382",
"DDInter1538"
] | Palonosetron | Propofol | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Moderate | 1 | [
[
[
1494,
24,
898
]
],
[
[
1494,
6,
12523
],
[
12523,
45,
898
]
],
[
[
1494,
21,
28882
],
[
28882,
60,
898
]
],
[
[
1494,
23,
112
],
[
112... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propofol"
]
],
[
[
"Palonosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)... | Palonosetron (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Propofol (Compound)
Palonosetron (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Propofol (Compound)
Palonosetron may cause a minor interaction that can limit clinical effects w... |
DB00404 | DB01205 | 523 | 1,404 | [
"DDInter54",
"DDInter748"
] | Alprazolam | Flumazenil | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system. | Moderate | 1 | [
[
[
523,
24,
1404
]
],
[
[
523,
6,
13500
],
[
13500,
45,
1404
]
],
[
[
523,
21,
29003
],
[
29003,
60,
1404
]
],
[
[
523,
1,
902
],
[
902,
... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flumazenil"
]
],
[
[
"Alprazolam",
"{u} (Compound) binds {v} (Gene)",
"GABRA5"
],
[
"GABRA5",
"{u} (Gene) is bound by {v} (Compound)",... | Alprazolam (Compound) binds GABRA5 (Gene) and GABRA5 (Gene) is bound by Flumazenil (Compound)
Alprazolam (Compound) causes Aggression (Side Effect) and Aggression (Side Effect) is caused by Flumazenil (Compound)
Alprazolam (Compound) resembles Clobazam (Compound) and Clobazam may cause a moderate interaction that could... |
DB00163 | DB00635 | 1,461 | 1,573 | [
"DDInter1943",
"DDInter1515"
] | Vitamin E | Prednisone | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Minor | 0 | [
[
[
1461,
23,
1573
]
],
[
[
1461,
23,
175
],
[
175,
40,
1573
]
],
[
[
1461,
23,
251
],
[
251,
1,
1573
]
],
[
[
1461,
24,
1018
],
[
1018,
... | [
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prednisone"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Triamcinolone"
],
[
... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisone (Compound)
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Betamethasone and Betamethasone (Compound) resembles Prednisone (Comp... |
DB00554 | DB08816 | 1,027 | 578 | [
"DDInter1478",
"DDInter1802"
] | Piroxicam | Ticagrelor | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
1027,
24,
578
]
],
[
[
1027,
63,
1578
],
[
1578,
24,
578
]
],
[
[
1027,
24,
723
],
[
723,
24,
578
]
],
[
[
1027,
64,
1172
],
[
1172,
... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lepirudin"
],
[
... | Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant... |
DB01611 | DB06717 | 1,487 | 875 | [
"DDInter893",
"DDInter778"
] | Hydroxychloroquine | Fosaprepitant | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
1487,
24,
875
]
],
[
[
1487,
63,
723
],
[
723,
1,
875
]
],
[
[
1487,
21,
29340
],
[
29340,
60,
875
]
],
[
[
1487,
24,
760
],
[
760,
... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepita... | Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Hydroxychloroquine (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Fosaprepitant (Co... |
DB00443 | DB11601 | 251 | 1,270 | [
"DDInter195",
"DDInter1889"
] | Betamethasone | Tuberculin purified protein derivative | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
251,
24,
1270
]
],
[
[
251,
24,
1531
],
[
1531,
24,
1270
]
],
[
[
251,
64,
1064
],
[
1064,
24,
1270
]
],
[
[
251,
1,
1486
],
[
1486,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Betamethasone may lead to a major life threatening interaction when taken with ... |
DB00813 | DB00902 | 704 | 104 | [
"DDInter722",
"DDInter1168"
] | Fentanyl | Methdilazine | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
704,
24,
104
]
],
[
[
704,
63,
13
],
[
13,
24,
104
]
],
[
[
704,
40,
11286
],
[
11286,
1,
104
]
],
[
[
704,
24,
820
],
[
820,
1,... | [
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
[
... | Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Fentanyl (Compound) resembles Diphenylpyraline (Compound) and Diphenylpyraline (Compound) resembles Meth... |
DB00500 | DB00741 | 24 | 167 | [
"DDInter1831",
"DDInter885"
] | Tolmetin | Hydrocortisone | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
24,
24,
167
]
],
[
[
24,
24,
1220
],
[
1220,
40,
167
]
],
[
[
24,
24,
870
],
[
870,
1,
167
]
],
[
[
24,
63,
251
],
[
251,
40,
... | [
[
[
"Tolmetin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Tolmetin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[... | Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Hydroc... |
DB00055 | DB00285 | 834 | 1,100 | [
"DDInter605",
"DDInter1927"
] | Drotrecogin alfa | Venlafaxine | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Moderate | 1 | [
[
[
834,
24,
1100
]
],
[
[
834,
24,
643
],
[
643,
40,
1100
]
],
[
[
834,
25,
235
],
[
235,
63,
1100
]
],
[
[
834,
25,
366
],
[
366,
... | [
[
[
"Drotrecogin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
]
],
[
[
"Drotrecogin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine... | Drotrecogin alfa may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desvenlafaxine (Compound) resembles Venlafaxine (Compound)
Drotrecogin alfa may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a moderate interaction that c... |
DB10315 | DB14762 | 1,137 | 994 | [
"DDInter1127",
"DDInter1602"
] | Measles virus vaccine live attenuated | Risankizumab | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and Europe in April 2019. Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease... | Major | 2 | [
[
[
1137,
25,
994
]
],
[
[
1137,
64,
4
],
[
4,
24,
994
]
],
[
[
1137,
25,
270
],
[
270,
24,
994
]
],
[
[
1137,
25,
676
],
[
676,
64,... | [
[
[
"Measles virus vaccine live attenuated",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Risankizumab"
]
],
[
[
"Measles virus vaccine live attenuated",
"{u} may lead to a major life threatening interaction when taken with {v}",
"O... | Measles virus vaccine live attenuated may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Risankizumab
Measles virus vaccine live attenuated may lead to a major life threa... |
DB00344 | DB01067 | 1,302 | 959 | [
"DDInter1543",
"DDInter826"
] | Protriptyline | Glipizide | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
1302,
24,
959
]
],
[
[
1302,
63,
245
],
[
245,
40,
959
]
],
[
[
1302,
24,
1411
],
[
1411,
1,
959
]
],
[
[
1302,
18,
6718
],
[
6718,
... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Co... |
DB00635 | DB08908 | 1,573 | 713 | [
"DDInter1515",
"DDInter564"
] | Prednisone | Dimethyl fumarate | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1573,
24,
713
]
],
[
[
1573,
24,
4
],
[
4,
24,
713
]
],
[
[
1573,
24,
270
],
[
270,
63,
713
]
],
[
[
1573,
1,
1220
],
[
1220,
24... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesucc... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Prednisone may cause a moderate interaction that could exacerbate diseases ... |
DB01309 | DB13620 | 1,254 | 948 | [
"DDInter933",
"DDInter1499"
] | Insulin glulisine | Potassium gluconate | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Potassium gluconate is a salt of and is classified as a food additive by the FDA . It is also used as a potassium supplement . Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function . In dietary supplements, potassium is ofte... | Minor | 0 | [
[
[
1254,
23,
948
]
],
[
[
1254,
63,
914
],
[
914,
24,
948
]
],
[
[
1254,
63,
1414
],
[
1414,
25,
948
]
],
[
[
1254,
24,
911
],
[
911,
... | [
[
[
"Insulin glulisine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Potassium gluconate"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diflun... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal and Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Potassium gluconate
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00218 | DB00889 | 1,176 | 1,133 | [
"DDInter1247",
"DDInter840"
] | Moxifloxacin | Granisetron | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Major | 2 | [
[
[
1176,
25,
1133
]
],
[
[
1176,
21,
28851
],
[
28851,
60,
1133
]
],
[
[
1176,
23,
112
],
[
112,
62,
1133
]
],
[
[
1176,
25,
1213
],
[
12... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Granisetron"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Hepatic enzyme increased"
],
[
"Hepatic enzyme increased",
"{u} (... | Moxifloxacin (Compound) causes Hepatic enzyme increased (Side Effect) and Hepatic enzyme increased (Side Effect) is caused by Granisetron (Compound)
Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit cli... |
DB00163 | DB09146 | 1,461 | 489 | [
"DDInter1943",
"DDInter978"
] | Vitamin E | Iron sucrose | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Moderate | 1 | [
[
[
1461,
24,
489
]
],
[
[
1461,
24,
1596
],
[
1596,
24,
489
]
],
[
[
1461,
24,
428
],
[
428,
63,
489
]
],
[
[
1461,
24,
1596
],
[
1596,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron sucrose"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
],
[
"I... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may cause a moderate interaction that could exacerbate diseases when taken with Iron sucrose
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous fuma... |
DB00361 | DB10429 | 134 | 200 | [
"DDInter1939",
"DDInter282"
] | Vinorelbine | Candida albicans | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
134,
24,
200
]
],
[
[
134,
24,
1683
],
[
1683,
24,
200
]
],
[
[
134,
25,
976
],
[
976,
24,
200
]
],
[
[
134,
63,
168
],
[
168,
2... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Vinorelbine may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitini... |
DB01097 | DB08913 | 1,377 | 1,186 | [
"DDInter1033",
"DDInter1561"
] | Leflunomide | Radium Ra 223 dichloride | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
1377,
24,
1186
]
],
[
[
1377,
21,
28722
],
[
28722,
60,
1186
]
],
[
[
1377,
25,
37
],
[
37,
24,
1186
]
],
[
[
1377,
64,
134
],
[
134,
... | [
[
[
"Leflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Leflunomide",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effec... | Leflunomide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Lomustine and Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 ... |
DB00073 | DB05679 | 1,394 | 1,683 | [
"DDInter1608",
"DDInter1907"
] | Rituximab | Ustekinumab | Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
1394,
24,
1683
]
],
[
[
1394,
23,
1461
],
[
1461,
23,
1683
]
],
[
[
1394,
23,
1193
],
[
1193,
62,
1683
]
],
[
[
1394,
24,
1362
],
[
13... | [
[
[
"Rituximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Rituximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Rituximab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab
Rituximab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc glucon... |
DB01170 | DB01240 | 1,150 | 885 | [
"DDInter846",
"DDInter657"
] | Guanethidine | Epoprostenol | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem] | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
1150,
24,
885
]
],
[
[
1150,
63,
1061
],
[
1061,
1,
885
]
],
[
[
1150,
24,
1450
],
[
1450,
63,
885
]
],
[
[
1150,
63,
1466
],
[
1466,
... | [
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Guanethidine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Guanethidine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate intera... |
DB00703 | DB00912 | 997 | 473 | [
"DDInter1167",
"DDInter1581"
] | Methazolamide | Repaglinide | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
997,
24,
473
]
],
[
[
997,
6,
8374
],
[
8374,
45,
473
]
],
[
[
997,
21,
28757
],
[
28757,
60,
473
]
],
[
[
997,
64,
1645
],
[
1645,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Methazolamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Methazolamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Repaglinide (Compound)
Methazolamide (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Repaglinide (Compound)
Methazolamide may lead to a major life threatening interaction when taken with Metformin and Metformin... |
DB00352 | DB01009 | 482 | 935 | [
"DDInter1814",
"DDInter1009"
] | Tioguanine | Ketoprofen | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
482,
24,
935
]
],
[
[
482,
24,
1523
],
[
1523,
40,
935
]
],
[
[
482,
63,
847
],
[
847,
1,
935
]
],
[
[
482,
24,
1274
],
[
1274,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Ketoprofen (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Ketoprofen (Compound)
... |
DB00489 | DB00836 | 17 | 543 | [
"DDInter1704",
"DDInter1088"
] | Sotalol | Loperamide | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
17,
24,
543
]
],
[
[
17,
24,
262
],
[
262,
24,
543
]
],
[
[
17,
25,
888
],
[
888,
24,
543
]
],
[
[
17,
21,
28722
],
[
28722,
60,... | [
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Sotalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clidinium"
],
[
"Cl... | Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Sotalol may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a moderate... |
DB01319 | DB11691 | 34 | 1,499 | [
"DDInter777",
"DDInter1258"
] | Fosamprenavir | Naldemedine | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Moderate | 1 | [
[
[
34,
24,
1499
]
],
[
[
34,
63,
723
],
[
723,
24,
1499
]
],
[
[
34,
25,
1670
],
[
1670,
24,
1499
]
],
[
[
34,
25,
1406
],
[
1406,
... | [
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naldemedine"
]
],
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine
Fosamprenavir may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may... |
DB00401 | DB11827 | 84 | 433 | [
"DDInter1298",
"DDInter669"
] | Nisoldipine | Ertugliflozin | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
84,
24,
433
]
],
[
[
84,
24,
251
],
[
251,
24,
433
]
],
[
[
84,
40,
1428
],
[
1428,
24,
433
]
],
[
[
84,
63,
999
],
[
999,
24,
... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
],
... | Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Nisoldipine (Compound) resembles Isradipine (Compound) and Isradipine may cause a moderate interaction... |
DB08820 | DB14761 | 1,478 | 242 | [
"DDInter997",
"DDInter1578"
] | Ivacaftor | Remdesivir | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1478,
24,
242
]
],
[
[
1478,
63,
467
],
[
467,
24,
242
]
],
[
[
1478,
64,
1377
],
[
1377,
24,
242
]
],
[
[
1478,
25,
129
],
[
129,
... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
],
[
... | Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Ivacaftor may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may caus... |
DB00014 | DB00420 | 521 | 508 | [
"DDInter839",
"DDInter1532"
] | Goserelin | Promazine | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Moderate | 1 | [
[
[
521,
24,
508
]
],
[
[
521,
24,
1264
],
[
1264,
63,
508
]
],
[
[
521,
24,
1630
],
[
1630,
1,
508
]
],
[
[
521,
24,
1237
],
[
1237,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
"D... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promazine
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine ... |
DB00559 | DB13074 | 152 | 877 | [
"DDInter223",
"DDInter1110"
] | Bosentan | Macimorelin | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
152,
24,
877
]
],
[
[
152,
24,
112
],
[
112,
23,
877
]
],
[
[
152,
24,
1320
],
[
1320,
24,
877
]
],
[
[
152,
25,
1019
],
[
1019,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagoli... |
DB00446 | DB00496 | 597 | 194 | [
"DDInter351",
"DDInter480"
] | Chloramphenicol | Darifenacin | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Moderate | 1 | [
[
[
597,
24,
194
]
],
[
[
597,
24,
704
],
[
704,
1,
194
]
],
[
[
597,
63,
576
],
[
576,
1,
194
]
],
[
[
597,
6,
8374
],
[
8374,
45,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darifenacin"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Darifenacin (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Methadone and Methadone (Compound) resembles Darifenacin (Comp... |
DB00983 | DB01087 | 480 | 1,520 | [
"DDInter776",
"DDInter1520"
] | Formoterol | Primaquine | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
480,
24,
1520
]
],
[
[
480,
24,
1487
],
[
1487,
64,
1520
]
],
[
[
480,
6,
12523
],
[
12523,
45,
1520
]
],
[
[
480,
21,
28722
],
[
2872... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
],
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Formoterol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound)
Formoterol (Compo... |
DB01234 | DB08896 | 1,220 | 292 | [
"DDInter513",
"DDInter1576"
] | Dexamethasone | Regorafenib | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
1220,
24,
292
]
],
[
[
1220,
63,
79
],
[
79,
1,
292
]
],
[
[
1220,
6,
6017
],
[
6017,
45,
292
]
],
[
[
1220,
7,
2546
],
[
2546,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Dexamethasone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Regorafenib (Compound)
Dexamethasone (Compound) upregulates RAF1 (Gene) and RAF1 (G... |
DB00420 | DB04868 | 508 | 478 | [
"DDInter1532",
"DDInter1293"
] | Promazine | Nilotinib | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
508,
25,
478
]
],
[
[
508,
6,
6017
],
[
6017,
45,
478
]
],
[
[
508,
7,
7669
],
[
7669,
46,
478
]
],
[
[
508,
18,
6929
],
[
6929,
... | [
[
[
"Promazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Promazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Nilotinib"... | Promazine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Promazine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Nilotinib (Compound)
Promazine (Compound) downregulates ITGAE (Gene) and ITGAE (Gene) is downregulated by Nilotinib (Compound)
Promazine (Compound)... |
DB05676 | DB15093 | 1,513 | 1,654 | [
"DDInter111",
"DDInter1698"
] | Apremilast | Somapacitan | Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1513,
24,
1654
]
],
[
[
1513,
24,
868
],
[
868,
24,
1654
]
],
[
[
1513,
25,
129
],
[
129,
24,
1654
]
],
[
[
1513,
63,
1324
],
[
1324,
... | [
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
[
... | Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Apremilast may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may... |
DB00624 | DB14723 | 1,561 | 159 | [
"DDInter1775",
"DDInter1026"
] | Testosterone | Larotrectinib | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1561,
24,
159
]
],
[
[
1561,
24,
98
],
[
98,
24,
159
]
],
[
[
1561,
63,
322
],
[
322,
24,
159
]
],
[
[
1561,
40,
1197
],
[
1197,
... | [
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
],
... | Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epi... |
DB00867 | DB11837 | 1,052 | 1,297 | [
"DDInter1606",
"DDInter1351"
] | Ritodrine | Osilodrostat | Adrenergic beta-agonist used to control premature labor. | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1052,
24,
1297
]
],
[
[
1052,
24,
222
],
[
222,
23,
1297
]
],
[
[
1052,
24,
401
],
[
401,
24,
1297
]
],
[
[
1052,
63,
1555
],
[
1555,
... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Prom... |
DB01254 | DB11642 | 1,213 | 938 | [
"DDInter484",
"DDInter1480"
] | Dasatinib | Pitolisant | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
1213,
24,
938
]
],
[
[
1213,
62,
112
],
[
112,
23,
938
]
],
[
[
1213,
25,
760
],
[
760,
24,
938
]
],
[
[
1213,
24,
28
],
[
28,
2... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Dasatinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Dasatinib may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may cause ... |
DB00446 | DB11703 | 597 | 405 | [
"DDInter351",
"DDInter9"
] | Chloramphenicol | Acalabrutinib | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
597,
24,
405
]
],
[
[
597,
24,
139
],
[
139,
24,
405
]
],
[
[
597,
62,
1101
],
[
1101,
24,
405
]
],
[
[
597,
25,
1598
],
[
1598,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Chloramphenicol may cause a minor interaction that can limit clinical effects when taken with Bexarotene... |
DB00004 | DB10795 | 669 | 221 | [
"DDInter499",
"DDInter1486"
] | Denileukin diftitox | Poliovirus type 1 antigen (formaldehyde inactivated) | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
669,
24,
221
]
],
[
[
669,
25,
581
],
[
581,
24,
221
]
],
[
[
669,
24,
599
],
[
599,
24,
221
]
],
[
[
669,
25,
676
],
[
676,
63,... | [
[
[
"Denileukin diftitox",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Denileukin diftitox",
"{u} may lead to a major life threatening interaction when taken ... | Denileukin diftitox may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Denileukin diftitox may cause a moderate interaction that could exacerbate d... |
DB00841 | DB06655 | 532 | 5 | [
"DDInter577",
"DDInter1077"
] | Dobutamine | Liraglutide | A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
532,
24,
5
]
],
[
[
532,
63,
245
],
[
245,
24,
5
]
],
[
[
532,
35,
480
],
[
480,
24,
5
]
],
[
[
532,
24,
1411
],
[
1411,
24,
... | [
[
[
"Dobutamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Dobutamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Dobutamine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Dobutamine (Compound) resembles Formoterol (Compound) and Dobutamine may cause a moderate interaction that co... |
DB00333 | DB00757 | 576 | 1,166 | [
"DDInter1166",
"DDInter581"
] | Methadone | Dolasetron | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
576,
25,
1166
]
],
[
[
576,
24,
19
],
[
19,
40,
1166
]
],
[
[
576,
24,
85
],
[
85,
1,
1166
]
],
[
[
576,
6,
12523
],
[
12523,
45... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hyoscyamine... | Methadone may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Dolasetron (Compound)
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Dolasetron (Compound)
Meth... |
DB00734 | DB01181 | 1,664 | 1,532 | [
"DDInter1605",
"DDInter906"
] | Risperidone | Ifosfamide | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
1664,
24,
1532
]
],
[
[
1664,
6,
7524
],
[
7524,
45,
1532
]
],
[
[
1664,
7,
5415
],
[
5415,
46,
1532
]
],
[
[
1664,
21,
28956
],
[
289... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Risperidone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)... | Risperidone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ifosfamide (Compound)
Risperidone (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Ifosfamide (Compound)
Risperidone (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compo... |
DB00388 | DB00414 | 1,636 | 590 | [
"DDInter1453",
"DDInter16"
] | Phenylephrine | Acetohexamide | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Moderate | 1 | [
[
[
1636,
24,
590
]
],
[
[
1636,
24,
1551
],
[
1551,
62,
590
]
],
[
[
1636,
24,
1163
],
[
1163,
63,
590
]
],
[
[
1636,
1,
874
],
[
874,
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyldopa"
],... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Methyldopa and Methyldopa may cause a minor interaction that can limit clinical effects when taken with Acetohexamide
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline and... |
DB00397 | DB01255 | 1,466 | 633 | [
"DDInter1458",
"DDInter1078"
] | Phenylpropanolamine | Lisdexamfetamine | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
1466,
24,
633
]
],
[
[
1466,
36,
551
],
[
551,
1,
633
]
],
[
[
1466,
1,
11215
],
[
11215,
1,
633
]
],
[
[
1466,
63,
80
],
[
80,
... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Phenylpropanolamine",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction whe... | Phenylpropanolamine (Compound) resembles Phenelzine (Compound) and Phenylpropanolamine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) resembles Lisdexamfetamine (Compound)
Phenylpropanolamine (Compound) resembles L-Phenylalanine (Compound) and L-Phenylalanine (Comp... |
DB00656 | DB00902 | 827 | 104 | [
"DDInter1851",
"DDInter1168"
] | Trazodone | Methdilazine | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
827,
24,
104
]
],
[
[
827,
40,
11224
],
[
11224,
1,
104
]
],
[
[
827,
63,
13
],
[
13,
24,
104
]
],
[
[
827,
24,
820
],
[
820,
1,... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Trazodone",
"{u} (Compound) resembles {v} (Compound)",
"Thioproperazine"
],
[
"Thioproperazine",
"{u} (Compound... | Trazodone (Compound) resembles Thioproperazine (Compound) and Thioproperazine (Compound) resembles Methdilazine (Compound)
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when take... |
DB00348 | DB01072 | 254 | 915 | [
"DDInter1300",
"DDInter129"
] | Nitisinone | Atazanavir | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Moderate | 1 | [
[
[
254,
24,
915
]
],
[
[
254,
24,
1327
],
[
1327,
1,
915
]
],
[
[
254,
21,
28810
],
[
28810,
60,
915
]
],
[
[
254,
24,
1374
],
[
1374,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atazanavir"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Atazanavir (Compound)
Nitisinone (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Atazanavir (Compound)
Nitisinone may cause... |
DB00938 | DB13139 | 455 | 1,032 | [
"DDInter1635",
"DDInter1063"
] | Salmeterol | Levosalbutamol | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
455,
24,
1032
]
],
[
[
455,
62,
218
],
[
218,
23,
1032
]
],
[
[
455,
23,
1486
],
[
1486,
23,
1032
]
],
[
[
455,
24,
1618
],
[
1618,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Salmeterol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Beclomethasone dipropiona... | Salmeterol may cause a minor interaction that can limit clinical effects when taken with Beclomethasone dipropionate and Beclomethasone dipropionate may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Salmeterol may cause a minor interaction that can limit clinical effects when ... |
DB00400 | DB11730 | 353 | 351 | [
"DDInter843",
"DDInter1588"
] | Griseofulvin | Ribociclib | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
353,
24,
351
]
],
[
[
353,
23,
271
],
[
271,
23,
351
]
],
[
[
353,
24,
466
],
[
466,
62,
351
]
],
[
[
353,
24,
479
],
[
479,
23,... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Griseofulvin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
... | Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Daro... |
DB12332 | DB14568 | 1,619 | 982 | [
"DDInter1626",
"DDInter1000"
] | Rucaparib | Ivosidenib | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1619,
25,
982
]
],
[
[
1619,
62,
271
],
[
271,
23,
982
]
],
[
[
1619,
63,
1101
],
[
1101,
23,
982
]
],
[
[
1619,
64,
976
],
[
976,
... | [
[
[
"Rucaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Rucaparib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"Mirabegron",
... | Rucaparib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene m... |
DB01149 | DB06605 | 851 | 1,409 | [
"DDInter1274",
"DDInter108"
] | Nefazodone | Apixaban | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
851,
24,
1409
]
],
[
[
851,
6,
4973
],
[
4973,
45,
1409
]
],
[
[
851,
21,
28787
],
[
28787,
60,
1409
]
],
[
[
851,
25,
1670
],
[
1670,... | [
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Nefazodone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Nefazodone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Apixaban (Compound)
Nefazodone (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Apixaban (Compound)
Nefazodone may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may cause a ... |
DB05679 | DB15091 | 1,683 | 676 | [
"DDInter1907",
"DDInter1901"
] | Ustekinumab | Upadacitinib | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1683,
25,
676
]
],
[
[
1683,
23,
1193
],
[
1193,
23,
676
]
],
[
[
1683,
62,
1461
],
[
1461,
23,
676
]
],
[
[
1683,
24,
1430
],
[
1430,... | [
[
[
"Ustekinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Ustekinumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc... | Ustekinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Ustekinumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and V... |
DB01156 | DB06282 | 593 | 516 | [
"DDInter252",
"DDInter1053"
] | Bupropion | Levocetirizine | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
593,
24,
516
]
],
[
[
593,
64,
1031
],
[
1031,
23,
516
]
],
[
[
593,
64,
1178
],
[
1178,
24,
516
]
],
[
[
593,
24,
697
],
[
697,
... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Theophylline"
],
[
"Theoph... | Bupropion may lead to a major life threatening interaction when taken with Theophylline and Theophylline may cause a minor interaction that can limit clinical effects when taken with Levocetirizine
Bupropion may lead to a major life threatening interaction when taken with Trifluoperazine and Trifluoperazine may cause a... |
DB00331 | DB01365 | 1,645 | 280 | [
"DDInter1164",
"DDInter1151"
] | Metformin | Mephentermine | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type depen... | Moderate | 1 | [
[
[
1645,
24,
280
]
],
[
[
1645,
24,
1445
],
[
1445,
1,
280
]
],
[
[
1645,
24,
22
],
[
22,
40,
280
]
],
[
[
1645,
18,
6797
],
[
6797,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephentermine"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
],
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine (Compound) resembles Mephentermine (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine (Compound) resembles Mephentermine... |
DB00708 | DB00719 | 1,454 | 1,219 | [
"DDInter1718",
"DDInter149"
] | Sufentanil | Azatadine | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
1454,
24,
1219
]
],
[
[
1454,
63,
13
],
[
13,
24,
1219
]
],
[
[
1454,
24,
830
],
[
830,
1,
1219
]
],
[
[
1454,
6,
8374
],
[
8374,
... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
[... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine a... |
DB04845 | DB14444 | 309 | 151 | [
"DDInter1001",
"DDInter924"
] | Ixabepilone | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
309,
24,
151
]
],
[
[
309,
63,
66
],
[
66,
24,
151
]
],
[
[
309,
24,
1619
],
[
1619,
24,
151
]
],
[
[
309,
25,
375
],
[
375,
24,... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Ixabepilone may cause a moderate int... |
DB00283 | DB01186 | 701 | 107 | [
"DDInter395",
"DDInter1430"
] | Clemastine | Pergolide | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic tr... | Moderate | 1 | [
[
[
701,
24,
107
]
],
[
[
701,
6,
12523
],
[
12523,
45,
107
]
],
[
[
701,
21,
28757
],
[
28757,
60,
107
]
],
[
[
701,
24,
832
],
[
832,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pergolide"
]
],
[
[
"Clemastine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Clemastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pergolide (Compound)
Clemastine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Pergolide (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tr... |
DB00245 | DB00470 | 357 | 530 | [
"DDInter181",
"DDInter601"
] | Benzatropine | Dronabinol | Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine upt... | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
357,
24,
530
]
],
[
[
357,
24,
1614
],
[
1614,
40,
530
]
],
[
[
357,
6,
10215
],
[
10215,
45,
530
]
],
[
[
357,
21,
29118
],
[
29118,
... | [
[
[
"Benzatropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Benzatropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
[
... | Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Benzatropine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Dronabinol (Compound)
Benzatropine (Compound) causes Tachycardia (Side Effect) and Tac... |
DB01211 | DB15093 | 609 | 1,654 | [
"DDInter393",
"DDInter1698"
] | Clarithromycin | Somapacitan | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
609,
24,
1654
]
],
[
[
609,
63,
168
],
[
168,
23,
1654
]
],
[
[
609,
24,
433
],
[
433,
24,
1654
]
],
[
[
609,
63,
1215
],
[
1215,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin ... |
DB01365 | DB09038 | 280 | 1,450 | [
"DDInter1151",
"DDInter636"
] | Mephentermine | Empagliflozin | A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type depen... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
280,
24,
1450
]
],
[
[
280,
24,
659
],
[
659,
63,
1450
]
],
[
[
280,
63,
1179
],
[
1179,
24,
1450
]
],
[
[
280,
40,
1445
],
[
1445,
... | [
[
[
"Mephentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Mephentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],... | Mephentermine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Mephentermine may cause a moderate interaction that could exacerbate diseases when taken with Insulin lisp... |
DB00983 | DB04861 | 480 | 1,592 | [
"DDInter776",
"DDInter1271"
] | Formoterol | Nebivolol | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
480,
24,
1592
]
],
[
[
480,
6,
3576
],
[
3576,
45,
1592
]
],
[
[
480,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
480,
24,
1450
],
[
1450,... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Formoterol",
"{u} (Compound) binds {v} (Gene)",
"ADRB2"
],
[
"ADRB2",
"{u} (Gene) is bound by {v} (Compound)",
... | Formoterol (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is bound by Nebivolol (Compound)
Formoterol (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagli... |
DB00024 | DB00331 | 818 | 1,645 | [
"DDInter1800",
"DDInter1164"
] | Thyrotropin alfa | Metformin | Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cance... | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Moderate | 1 | [
[
[
818,
24,
1645
]
],
[
[
818,
24,
1647
],
[
1647,
23,
1645
]
],
[
[
818,
24,
1296
],
[
1296,
63,
1645
]
],
[
[
818,
24,
1179
],
[
1179,
... | [
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
]
],
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],... | Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Metformin
Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec... |
DB00222 | DB01015 | 245 | 1,247 | [
"DDInter825",
"DDInter1724"
] | Glimepiride | Sulfamethoxazole | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Moderate | 1 | [
[
[
245,
24,
1247
]
],
[
[
245,
24,
1029
],
[
1029,
1,
1247
]
],
[
[
245,
1,
11499
],
[
11499,
1,
1247
]
],
[
[
245,
6,
6017
],
[
6017,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfisoxazole"
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Sulfisoxazole and Sulfisoxazole (Compound) resembles Sulfamethoxazole (Compound)
Glimepiride (Compound) resembles Glisoxepide (Compound) and Glisoxepide (Compound) resembles Sulfamethoxazole (Compound)
Glimepiride (Compound) bin... |
DB00950 | DB12941 | 1,413 | 466 | [
"DDInter732",
"DDInter481"
] | Fexofenadine | Darolutamide | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
1413,
24,
466
]
],
[
[
1413,
62,
1622
],
[
1622,
23,
466
]
],
[
[
1413,
24,
1623
],
[
1623,
23,
466
]
],
[
[
1413,
23,
86
],
[
86,
... | [
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Fexofenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Voriconazole"
],
... | Fexofenadine may cause a minor interaction that can limit clinical effects when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium... |
DB00647 | DB14568 | 675 | 982 | [
"DDInter528",
"DDInter1000"
] | Dextropropoxyphene | Ivosidenib | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
675,
25,
982
]
],
[
[
675,
23,
112
],
[
112,
23,
982
]
],
[
[
675,
24,
976
],
[
976,
24,
982
]
],
[
[
675,
25,
770
],
[
770,
24,... | [
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Dextropropoxyphene may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Tof... |
DB00176 | DB01240 | 529 | 885 | [
"DDInter770",
"DDInter657"
] | Fluvoxamine | Epoprostenol | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
529,
24,
885
]
],
[
[
529,
24,
1061
],
[
1061,
1,
885
]
],
[
[
529,
6,
6017
],
[
6017,
45,
885
]
],
[
[
529,
21,
28684
],
[
28684,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Fluvoxamine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Epoprostenol (Compound)
Fluvoxamine (Compound) causes Hypoaesthesia (Side Effect... |
DB00108 | DB00445 | 1,066 | 322 | [
"DDInter1268",
"DDInter655"
] | Natalizumab | Epirubicin | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Major | 2 | [
[
[
1066,
25,
322
]
],
[
[
1066,
25,
1307
],
[
1307,
62,
322
]
],
[
[
1066,
64,
1648
],
[
1648,
24,
322
]
],
[
[
1066,
25,
1224
],
[
1224,... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epirubicin"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Melphalan"
],
[
"Melphalan",
"{u} m... | Natalizumab may lead to a major life threatening interaction when taken with Melphalan and Melphalan may cause a minor interaction that can limit clinical effects when taken with Epirubicin
Natalizumab may lead to a major life threatening interaction when taken with Aldesleukin and Aldesleukin may cause a moderate inte... |
DB01001 | DB01410 | 688 | 423 | [
"DDInter1632",
"DDInter375"
] | Salbutamol | Ciclesonide | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Minor | 0 | [
[
[
688,
23,
423
]
],
[
[
688,
62,
1573
],
[
1573,
1,
423
]
],
[
[
688,
62,
1351
],
[
1351,
40,
423
]
],
[
[
688,
23,
617
],
[
617,
... | [
[
[
"Salbutamol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ciclesonide"
]
],
[
[
"Salbutamol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prednisone"
],
[
... | Salbutamol may cause a minor interaction that can limit clinical effects when taken with Prednisone and Prednisone (Compound) resembles Ciclesonide (Compound)
Salbutamol may cause a minor interaction that can limit clinical effects when taken with Flunisolide and Flunisolide (Compound) resembles Ciclesonide (Compound)
... |
DB01073 | DB12834 | 1,488 | 148 | [
"DDInter745",
"DDInter1649"
] | Fludarabine | Secnidazole | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
1488,
24,
148
]
],
[
[
1488,
24,
1593
],
[
1593,
24,
148
]
],
[
[
1488,
63,
597
],
[
597,
24,
148
]
],
[
[
1488,
25,
1510
],
[
1510,
... | [
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol an... |
DB01114 | DB04946 | 272 | 924 | [
"DDInter362",
"DDInter907"
] | Chlorpheniramine | Iloperidone | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
272,
24,
924
]
],
[
[
272,
63,
1664
],
[
1664,
1,
924
]
],
[
[
272,
24,
519
],
[
519,
40,
924
]
],
[
[
272,
6,
10104
],
[
10104,
... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
... | Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Ilo... |
DB00264 | DB00757 | 88 | 1,166 | [
"DDInter1200",
"DDInter581"
] | Metoprolol | Dolasetron | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
88,
25,
1166
]
],
[
[
88,
24,
19
],
[
19,
40,
1166
]
],
[
[
88,
24,
85
],
[
85,
1,
1166
]
],
[
[
88,
6,
12523
],
[
12523,
45,
... | [
[
[
"Metoprolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hyoscyami... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Dolasetron (Compound)
Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Dolasetron (Compound)
Me... |
DB08938 | DB13997 | 1,384 | 133 | [
"DDInter1112",
"DDInter163"
] | Magaldrate | Baloxavir marboxil | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Baloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.[A39895, A251755] It is a prodrug of [baloxavir] with an improved absorption profile than its active metabolite due to the add... | Moderate | 1 | [
[
[
1384,
24,
133
]
],
[
[
1384,
24,
428
],
[
428,
63,
133
]
],
[
[
1384,
63,
417
],
[
417,
24,
133
]
],
[
[
1384,
24,
428
],
[
428,
... | [
[
[
"Magaldrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baloxavir marboxil"
]
],
[
[
"Magaldrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
... | Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate interaction that could exacerbate diseases when taken with Baloxavir marboxil
Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with S... |
DB00945 | DB12364 | 1,479 | 1,421 | [
"DDInter20",
"DDInter200"
] | Acetylsalicylic acid | Betrixaban | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
1479,
25,
1421
]
],
[
[
1479,
23,
297
],
[
297,
23,
1421
]
],
[
[
1479,
23,
1631
],
[
1631,
62,
1421
]
],
[
[
1479,
24,
992
],
[
992,
... | [
[
[
"Acetylsalicylic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
... | Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Betrixaban
Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turm... |
DB01197 | DB06335 | 1,603 | 761 | [
"DDInter292",
"DDInter1646"
] | Captopril | Saxagliptin | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1603,
24,
761
]
],
[
[
1603,
21,
28722
],
[
28722,
60,
761
]
],
[
[
1603,
63,
104
],
[
104,
24,
761
]
],
[
[
1603,
24,
1296
],
[
1296,... | [
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Captopril",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {... | Captopril (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Saxaglipti... |
DB00196 | DB11986 | 600 | 484 | [
"DDInter743",
"DDInter648"
] | Fluconazole | Entrectinib | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
600,
25,
484
]
],
[
[
600,
23,
1247
],
[
1247,
23,
484
]
],
[
[
600,
23,
466
],
[
466,
62,
484
]
],
[
[
600,
25,
1135
],
[
1135,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sul... | Fluconazole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide... |
DB00543 | DB00986 | 87 | 1,192 | [
"DDInter82",
"DDInter834"
] | Amoxapine | Glycopyrronium | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
87,
24,
1192
]
],
[
[
87,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
87,
24,
262
],
[
262,
24,
1192
]
],
[
[
87,
6,
7992
],
[
7992,
4... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[... | Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Cli... |
DB01211 | DB01403 | 609 | 9 | [
"DDInter393",
"DDInter1175"
] | Clarithromycin | Methotrimeprazine | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
609,
24,
9
]
],
[
[
609,
63,
1178
],
[
1178,
40,
9
]
],
[
[
609,
63,
1164
],
[
1164,
1,
9
]
],
[
[
609,
64,
684
],
[
684,
40,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperaz... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) res... |
DB01166 | DB08865 | 477 | 1,593 | [
"DDInter379",
"DDInter448"
] | Cilostazol | Crizotinib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
477,
25,
1593
]
],
[
[
477,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
477,
7,
3727
],
[
3727,
46,
1593
]
],
[
[
477,
18,
4303
],
[
4303,
... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Cilostazol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizoti... | Cilostazol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Cilostazol (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Crizotinib (Compound)
Cilostazol (Compound) downregulates CLTB (Gene) and CLTB (Gene) is downregulated by Crizotinib (Compound)
Cilostazol (Compound... |
DB00014 | DB01255 | 521 | 633 | [
"DDInter839",
"DDInter1078"
] | Goserelin | Lisdexamfetamine | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
521,
24,
633
]
],
[
[
521,
21,
28730
],
[
28730,
60,
633
]
],
[
[
521,
23,
112
],
[
112,
23,
633
]
],
[
[
521,
24,
1494
],
[
1494,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Goserelin",
"{u} (Compound) causes {v} (Side Effect)",
"Psychotic disorder"
],
[
"Psychotic disorder",
"{u}... | Goserelin (Compound) causes Psychotic disorder (Side Effect) and Psychotic disorder (Side Effect) is caused by Lisdexamfetamine (Compound)
Goserelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects... |
DB00749 | DB11703 | 59 | 405 | [
"DDInter699",
"DDInter9"
] | Etodolac | Acalabrutinib | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
59,
25,
405
]
],
[
[
59,
23,
1194
],
[
1194,
24,
405
]
],
[
[
59,
62,
752
],
[
752,
24,
405
]
],
[
[
59,
63,
121
],
[
121,
24,
... | [
[
[
"Etodolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Etodolac",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
],
[
"Ranitidine",
... | Etodolac may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranitidine may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Etodolac may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine ... |
DB00486 | DB00800 | 1,614 | 572 | [
"DDInter1253",
"DDInter720"
] | Nabilone | Fenoldopam | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. | Moderate | 1 | [
[
[
1614,
24,
572
]
],
[
[
1614,
21,
28658
],
[
28658,
60,
572
]
],
[
[
1614,
24,
274
],
[
274,
24,
572
]
],
[
[
1614,
63,
999
],
[
999,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenoldopam"
]
],
[
[
"Nabilone",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caused by ... | Nabilone (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Fenoldopam (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine and Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Fenoldopa... |
DB01059 | DB05812 | 956 | 1,374 | [
"DDInter1313",
"DDInter8"
] | Norfloxacin | Abiraterone | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
956,
24,
1374
]
],
[
[
956,
6,
8374
],
[
8374,
45,
1374
]
],
[
[
956,
21,
28661
],
[
28661,
60,
1374
]
],
[
[
956,
62,
112
],
[
112,
... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Norfloxacin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Norfloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Abiraterone (Compound)
Norfloxacin (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Abiraterone (Compound)
Norfloxacin may cause a minor interaction that can limit clinical effects when... |
DB00831 | DB05812 | 1,178 | 1,374 | [
"DDInter1866",
"DDInter8"
] | Trifluoperazine | Abiraterone | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
1178,
24,
1374
]
],
[
[
1178,
21,
28695
],
[
28695,
60,
1374
]
],
[
[
1178,
23,
112
],
[
112,
23,
1374
]
],
[
[
1178,
1,
851
],
[
851,... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Trifluoperazine",
"{u} (Compound) causes {v} (Side Effect)",
"Dyspnoea"
],
[
"Dyspnoea",
"{u} (Side Effect... | Trifluoperazine (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Abiraterone (Compound)
Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken w... |
DB00668 | DB06292 | 874 | 549 | [
"DDInter652",
"DDInter474"
] | Epinephrine | Dapagliflozin | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
874,
24,
549
]
],
[
[
874,
24,
1344
],
[
1344,
40,
549
]
],
[
[
874,
6,
8374
],
[
8374,
45,
549
]
],
[
[
874,
21,
29222
],
[
29222,
... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Epinephrine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Epinephrine (Compound) causes Hypoglycaemia (Side Ef... |
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