drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00446 | DB01327 | 597 | 1,227 | [
"DDInter351",
"DDInter314"
] | Chloramphenicol | Cefazolin | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. | Moderate | 1 | [
[
[
597,
24,
1227
]
],
[
[
597,
24,
1124
],
[
1124,
40,
1227
]
],
[
[
597,
63,
277
],
[
277,
1,
1227
]
],
[
[
597,
24,
1145
],
[
1145,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefazolin"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefamandole"
]... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Cefamandole and Cefamandole (Compound) resembles Cefazolin (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Cefmetazole and Cefmetazole (Compound) resembles Cefazolin... |
DB00059 | DB00289 | 1,560 | 847 | [
"DDInter1404",
"DDInter132"
] | Pegaspargase | Atomoxetine | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Moderate | 1 | [
[
[
1560,
24,
847
]
],
[
[
1560,
24,
109
],
[
109,
40,
847
]
],
[
[
1560,
24,
126
],
[
126,
1,
847
]
],
[
[
1560,
24,
609
],
[
609,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) resembles Atomoxetine (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin (Compound) resembles Atomoxetine (Compound... |
DB01030 | DB01155 | 869 | 872 | [
"DDInter1835",
"DDInter813"
] | Topotecan | Gemifloxacin | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Minor | 0 | [
[
[
869,
23,
872
]
],
[
[
869,
62,
739
],
[
739,
1,
872
]
],
[
[
869,
23,
956
],
[
956,
1,
872
]
],
[
[
869,
23,
945
],
[
945,
40,
... | [
[
[
"Topotecan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Topotecan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Topotecan may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Topotecan may cause a minor interaction that can limit clinical effects when taken with Norfloxacin and Norfloxacin (Compound) resembles Gemifloxacin (Compou... |
DB00196 | DB00439 | 600 | 289 | [
"DDInter743",
"DDInter341"
] | Fluconazole | Cerivastatin | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Major | 2 | [
[
[
600,
25,
289
]
],
[
[
600,
24,
1491
],
[
1491,
63,
289
]
],
[
[
600,
63,
1560
],
[
1560,
24,
289
]
],
[
[
600,
24,
134
],
[
134,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cerivastatin"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
],
[
"Midos... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Cerivastatin
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase an... |
DB01182 | DB06788 | 371 | 1,616 | [
"DDInter1534",
"DDInter864"
] | Propafenone | Histrelin | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
371,
24,
1616
]
],
[
[
371,
62,
112
],
[
112,
23,
1616
]
],
[
[
371,
24,
1342
],
[
1342,
24,
1616
]
],
[
[
371,
63,
77
],
[
77,
... | [
[
[
"Propafenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Propafenone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Propafenone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin and Rom... |
DB09054 | DB11952 | 384 | 800 | [
"DDInter905",
"DDInter612"
] | Idelalisib | Duvelisib | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Major | 2 | [
[
[
384,
25,
800
]
],
[
[
384,
24,
466
],
[
466,
62,
800
]
],
[
[
384,
62,
222
],
[
222,
23,
800
]
],
[
[
384,
63,
310
],
[
310,
24,... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Duvelisib"
]
],
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Darolutam... | Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Duvelisib
Idelalisib may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutr... |
DB01591 | DB09082 | 667 | 659 | [
"DDInter1696",
"DDInter1934"
] | Solifenacin | Vilanterol | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
667,
24,
659
]
],
[
[
667,
63,
1220
],
[
1220,
23,
659
]
],
[
[
667,
24,
927
],
[
927,
63,
659
]
],
[
[
667,
25,
1069
],
[
1069,
... | [
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and... |
DB00390 | DB01041 | 1,252 | 770 | [
"DDInter554",
"DDInter1789"
] | Digoxin | Thalidomide | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1252,
24,
770
]
],
[
[
1252,
24,
1668
],
[
1668,
1,
770
]
],
[
[
1252,
7,
7720
],
[
7720,
45,
770
]
],
[
[
1252,
18,
5051
],
[
5051,
... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenalidomide"
],
[
... | Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Lenalidomide and Lenalidomide (Compound) resembles Thalidomide (Compound)
Digoxin (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Thalidomide (Compound)
Digoxin (Compound) downregulates SMARCD2 (Gene) and SMARCD2 (G... |
DB00615 | DB01067 | 690 | 959 | [
"DDInter1589",
"DDInter826"
] | Rifabutin | Glipizide | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
690,
24,
959
]
],
[
[
690,
63,
245
],
[
245,
40,
959
]
],
[
[
690,
24,
1411
],
[
1411,
1,
959
]
],
[
[
690,
6,
8374
],
[
8374,
4... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound)
... |
DB00685 | DB01005 | 1,299 | 995 | [
"DDInter1887",
"DDInter894"
] | Trovafloxacin | Hydroxyurea | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Minor | 0 | [
[
[
1299,
23,
995
]
],
[
[
1299,
21,
29276
],
[
29276,
60,
995
]
],
[
[
1299,
1,
872
],
[
872,
62,
995
]
],
[
[
1299,
1,
739
],
[
739,
... | [
[
[
"Trovafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroxyurea"
]
],
[
[
"Trovafloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Haemoglobin"
],
[
"Haemoglobin",
"{u} (Side Effect... | Trovafloxacin (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Hydroxyurea (Compound)
Trovafloxacin (Compound) resembles Gemifloxacin (Compound) and Gemifloxacin may cause a minor interaction that can limit clinical effects when taken with Hydroxyurea
Trovafloxacin (Compound) resem... |
DB01246 | DB01589 | 820 | 481 | [
"DDInter45",
"DDInter1552"
] | Alimemazine | Quazepam | A phenothiazine derivative that is used as an antipruritic. | Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors a... | Moderate | 1 | [
[
[
820,
24,
481
]
],
[
[
820,
63,
1216
],
[
1216,
1,
481
]
],
[
[
820,
63,
905
],
[
905,
40,
481
]
],
[
[
820,
6,
8374
],
[
8374,
4... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quazepam"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
],
[
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Quazepam (Compound)
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Lorazepam and Lorazepam (Compound) resembles Quazepam (Compound)
Alim... |
DB00295 | DB01168 | 475 | 1,053 | [
"DDInter1244",
"DDInter1526"
] | Morphine | Procarbazine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Major | 2 | [
[
[
475,
25,
1053
]
],
[
[
475,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
475,
24,
1299
],
[
1299,
23,
1053
]
],
[
[
475,
24,
9
],
[
9,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procarbazine"
]
],
[
[
"Morphine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by {v} (Compound... | Morphine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Trovafloxacin and Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Procarb... |
DB00731 | DB01577 | 1,144 | 1,529 | [
"DDInter1269",
"DDInter1161"
] | Nateglinide | Metamfetamine | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Moderate | 1 | [
[
[
1144,
35,
1529
]
],
[
[
1144,
24,
939
],
[
939,
40,
1529
]
],
[
[
1144,
1,
94
],
[
94,
1,
1529
]
],
[
[
1144,
1,
80
],
[
80,
40,... | [
[
[
"Nateglinide",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when ta... | Nateglinide (Compound) resembles Metamfetamine (Compound) and
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Metamfetamine (Compound)
Nateglinide (Compound) resembles Phenacemide (Compound) and Phenacemide (Compound) resem... |
DB00889 | DB09330 | 1,133 | 985 | [
"DDInter840",
"DDInter1352"
] | Granisetron | Osimertinib | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
1133,
25,
985
]
],
[
[
1133,
23,
1247
],
[
1247,
23,
985
]
],
[
[
1133,
24,
1478
],
[
1478,
24,
985
]
],
[
[
1133,
24,
1598
],
[
1598,... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Granisetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sul... | Granisetron may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor ... |
DB00701 | DB01410 | 1,091 | 423 | [
"DDInter90",
"DDInter376"
] | Amprenavir | Ciclesonide (nasal) | Amprenavir is a protease inhibitor used to treat HIV infection. | Ciclesonide is an organic molecular entity. | Moderate | 1 | [
[
[
1091,
24,
423
]
],
[
[
1091,
63,
1573
],
[
1573,
1,
423
]
],
[
[
1091,
63,
1351
],
[
1351,
40,
423
]
],
[
[
1091,
25,
1486
],
[
1486,
... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ciclesonide"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Ciclesonide
Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Ciclesonide (Compound)
Amprenavir may cause a moderate interaction that could e... |
DB00081 | DB12500 | 273 | 283 | [
"DDInter1838",
"DDInter714"
] | Tositumomab | Fedratinib | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
273,
25,
283
]
],
[
[
273,
25,
885
],
[
885,
24,
283
]
],
[
[
273,
24,
529
],
[
529,
24,
283
]
],
[
[
273,
25,
676
],
[
676,
63,... | [
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epoprostenol"
],
[
"Epoprostenol",
... | Tositumomab may lead to a major life threatening interaction when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine and Fluvoxamine ma... |
DB04948 | DB14568 | 1,084 | 982 | [
"DDInter1083",
"DDInter1000"
] | Lofexidine | Ivosidenib | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1084,
25,
982
]
],
[
[
1084,
62,
112
],
[
112,
23,
982
]
],
[
[
1084,
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[
976,
24,
982
]
],
[
[
1084,
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543
],
[
543,
... | [
[
[
"Lofexidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Lofexidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Lofexidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tof... |
DB00215 | DB00374 | 1,230 | 1,061 | [
"DDInter388",
"DDInter1852"
] | Citalopram | Treprostinil | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Moderate | 1 | [
[
[
1230,
24,
1061
]
],
[
[
1230,
24,
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],
[
885,
40,
1061
]
],
[
[
1230,
18,
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],
[
3950,
57,
1061
]
],
[
[
1230,
7,
8587
],
[
8587,... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol (Compound) resembles Treprostinil (Compound)
Citalopram (Compound) downregulates RNH1 (Gene) and RNH1 (Gene) is downregulated by Treprostinil (Compound)
Citalopram (Compound) upregulates RRS1 (Gene) ... |
DB00281 | DB12332 | 608 | 1,619 | [
"DDInter1066",
"DDInter1626"
] | Lidocaine | Rucaparib | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
608,
24,
1619
]
],
[
[
608,
23,
307
],
[
307,
23,
1619
]
],
[
[
608,
24,
259
],
[
259,
24,
1619
]
],
[
[
608,
63,
58
],
[
58,
24... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
"M... | Lidocaine may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may ... |
DB09146 | DB14550 | 489 | 821 | [
"DDInter978",
"DDInter803"
] | Iron sucrose | Gallium chloride Ga-67 | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Gallium chloride Ga-67 is the chloride salt of a gallium radioisotope which is typically complexed with [sodium citrate] to generate [gallium citrate Ga 67], which can be used to image certain cancers and inflammatory lesions. | Moderate | 1 | [
[
[
489,
24,
821
]
],
[
[
489,
24,
428
],
[
428,
24,
821
]
],
[
[
489,
63,
1596
],
[
1596,
24,
821
]
],
[
[
489,
63,
1058
],
[
1058,
... | [
[
[
"Iron sucrose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gallium chloride Ga-67"
]
],
[
[
"Iron sucrose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fum... | Iron sucrose may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate interaction that could exacerbate diseases when taken with Gallium chloride Ga-67
Iron sucrose may cause a moderate interaction that could exacerbate diseases when take... |
DB00444 | DB00834 | 63 | 932 | [
"DDInter1765",
"DDInter1215"
] | Teniposide | Mifepristone | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Moderate | 1 | [
[
[
63,
24,
932
]
],
[
[
63,
6,
7524
],
[
7524,
45,
932
]
],
[
[
63,
7,
2884
],
[
2884,
46,
932
]
],
[
[
63,
18,
5235
],
[
5235,
46,... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mifepristone"
]
],
[
[
"Teniposide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)... | Teniposide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Mifepristone (Compound)
Teniposide (Compound) upregulates ECH1 (Gene) and ECH1 (Gene) is upregulated by Mifepristone (Compound)
Teniposide (Compound) downregulates AARS (Gene) and AARS (Gene) is upregulated by Mifepristone (Compound)
Teniposide (Co... |
DB00078 | DB06168 | 1,172 | 1,531 | [
"DDInter898",
"DDInter281"
] | Ibritumomab tiuxetan | Canakinumab | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
1172,
24,
1531
]
],
[
[
1172,
24,
1270
],
[
1270,
63,
1531
]
],
[
[
1172,
25,
1213
],
[
1213,
24,
1531
]
],
[
[
1172,
25,
1409
],
[
14... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberc... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Ibritumomab tiuxetan may lead to a major life... |
DB00518 | DB11901 | 510 | 913 | [
"DDInter35",
"DDInter107"
] | Albendazole | Apalutamide | A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38) | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
510,
24,
913
]
],
[
[
510,
62,
608
],
[
608,
23,
913
]
],
[
[
510,
24,
859
],
[
859,
24,
913
]
],
[
[
510,
24,
1619
],
[
1619,
6... | [
[
[
"Albendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Albendazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lidocaine"
],
[
... | Albendazole may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Albendazole may cause a moderate interaction that could exacerbate diseases when taken with Posaconazole and Posacon... |
DB01603 | DB09420 | 1,366 | 1,074 | [
"DDInter1195",
"DDInter953"
] | Meticillin | Iodide I-123 | One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1366,
24,
1074
]
],
[
[
1366,
40,
339
],
[
339,
24,
1074
]
],
[
[
1366,
63,
126
],
[
126,
24,
1074
]
],
[
[
1366,
1,
790
],
[
790,
... | [
[
[
"Meticillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Meticillin",
"{u} (Compound) resembles {v} (Compound)",
"Bacampicillin"
],
[
"Bacampicillin",
"{u} may cause a... | Meticillin (Compound) resembles Bacampicillin (Compound) and Bacampicillin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Meticillin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that c... |
DB01041 | DB11186 | 770 | 1,609 | [
"DDInter1789",
"DDInter1427"
] | Thalidomide | Pentoxyverine | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
770,
24,
1609
]
],
[
[
770,
63,
314
],
[
314,
24,
1609
]
],
[
[
770,
24,
716
],
[
716,
24,
1609
]
],
[
[
770,
24,
418
],
[
418,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Dantrolene and D... |
DB01030 | DB12941 | 869 | 466 | [
"DDInter1835",
"DDInter481"
] | Topotecan | Darolutamide | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
869,
24,
466
]
],
[
[
869,
24,
1623
],
[
1623,
23,
466
]
],
[
[
869,
63,
597
],
[
597,
23,
466
]
],
[
[
869,
24,
738
],
[
738,
2... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
],
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium and Isavuconazonium may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenic... |
DB00444 | DB08889 | 63 | 350 | [
"DDInter1765",
"DDInter299"
] | Teniposide | Carfilzomib | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
63,
24,
350
]
],
[
[
63,
7,
5795
],
[
5795,
45,
350
]
],
[
[
63,
21,
28762
],
[
28762,
60,
350
]
],
[
[
63,
24,
1270
],
[
1270,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Teniposide",
"{u} (Compound) upregulates {v} (Gene)",
"PSMB8"
],
[
"PSMB8",
"{u} (Gene) is bound by {v} (Compou... | Teniposide (Compound) upregulates PSMB8 (Gene) and PSMB8 (Gene) is bound by Carfilzomib (Compound)
Teniposide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin puri... |
DB00741 | DB00831 | 167 | 1,178 | [
"DDInter885",
"DDInter1866"
] | Hydrocortisone | Trifluoperazine | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
167,
24,
1178
]
],
[
[
167,
24,
851
],
[
851,
40,
1178
]
],
[
[
167,
63,
216
],
[
216,
40,
1178
]
],
[
[
167,
6,
4973
],
[
4973,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Trifluoperazine (Compound)
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) resembles T... |
DB00063 | DB06228 | 366 | 792 | [
"DDInter659",
"DDInter1609"
] | Eptifibatide | Rivaroxaban | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
366,
25,
792
]
],
[
[
366,
23,
944
],
[
944,
62,
792
]
],
[
[
366,
24,
901
],
[
901,
24,
792
]
],
[
[
366,
24,
738
],
[
738,
63,... | [
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Eptifibatide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomil... | Eptifibatide may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Rivaroxaban
Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnac... |
DB01009 | DB01254 | 935 | 1,213 | [
"DDInter1009",
"DDInter484"
] | Ketoprofen | Dasatinib | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
935,
25,
1213
]
],
[
[
935,
18,
7359
],
[
7359,
57,
1213
]
],
[
[
935,
21,
28956
],
[
28956,
60,
1213
]
],
[
[
935,
24,
738
],
[
738,
... | [
[
[
"Ketoprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Ketoprofen",
"{u} (Compound) downregulates {v} (Gene)",
"TXNDC9"
],
[
"TXNDC9",
"{u} (Gene) is downregulated by {v} (Compound)",... | Ketoprofen (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Dasatinib (Compound)
Ketoprofen (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Dasatinib (Compound)
Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01156 | DB01178 | 593 | 369 | [
"DDInter252",
"DDInter357"
] | Bupropion | Chlormezanone | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. | Moderate | 1 | [
[
[
593,
24,
369
]
],
[
[
593,
18,
4930
],
[
4930,
57,
369
]
],
[
[
593,
24,
1532
],
[
1532,
63,
369
]
],
[
[
593,
63,
272
],
[
272,
... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlormezanone"
]
],
[
[
"Bupropion",
"{u} (Compound) downregulates {v} (Gene)",
"DLD"
],
[
"DLD",
"{u} (Gene) is downregulated by {v} (... | Bupropion (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Chlormezanone (Compound)
Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Chlormezanone
Bupr... |
DB00834 | DB11703 | 932 | 405 | [
"DDInter1215",
"DDInter9"
] | Mifepristone | Acalabrutinib | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
932,
25,
405
]
],
[
[
932,
63,
1051
],
[
1051,
24,
405
]
],
[
[
932,
62,
1101
],
[
1101,
24,
405
]
],
[
[
932,
24,
1446
],
[
1446,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
[
... | Mifepristone may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Mifepristone may cause a minor interaction that can limit clinical effects when taken with Be... |
DB00877 | DB01006 | 629 | 300 | [
"DDInter1678",
"DDInter1040"
] | Sirolimus | Letrozole | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Moderate | 1 | [
[
[
629,
24,
300
]
],
[
[
629,
6,
8374
],
[
8374,
45,
300
]
],
[
[
629,
7,
16192
],
[
16192,
46,
300
]
],
[
[
629,
18,
5833
],
[
5833,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Letrozole"
]
],
[
[
"Sirolimus",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Sirolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Letrozole (Compound)
Sirolimus (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Letrozole (Compound)
Sirolimus (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is downregulated by Letrozole (Compound)
Sirolimus (Com... |
DB00035 | DB00580 | 1,314 | 311 | [
"DDInter507",
"DDInter1910"
] | Desmopressin | Valdecoxib | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Moderate | 1 | [
[
[
1314,
24,
311
]
],
[
[
1314,
25,
251
],
[
251,
24,
311
]
],
[
[
1314,
24,
1512
],
[
1512,
63,
311
]
],
[
[
1314,
25,
1220
],
[
1220,
... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valdecoxib"
]
],
[
[
"Desmopressin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betamethasone"
],
[
"Bet... | Desmopressin may lead to a major life threatening interaction when taken with Betamethasone and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Valdecoxib
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac ... |
DB00358 | DB00754 | 1,010 | 157 | [
"DDInter1140",
"DDInter696"
] | Mefloquine | Ethotoin | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Moderate | 1 | [
[
[
1010,
24,
157
]
],
[
[
1010,
24,
759
],
[
759,
40,
157
]
],
[
[
1010,
24,
499
],
[
499,
1,
157
]
],
[
[
1010,
21,
28763
],
[
28763,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethotoin"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Ethotoin (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Phensuximide and Phensuximide (Compound) resembles Ethotoin (Compound)
Me... |
DB00748 | DB01589 | 662 | 481 | [
"DDInter297",
"DDInter1552"
] | Carbinoxamine | Quazepam | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors a... | Moderate | 1 | [
[
[
662,
24,
481
]
],
[
[
662,
63,
1216
],
[
1216,
1,
481
]
],
[
[
662,
24,
1418
],
[
1418,
1,
481
]
],
[
[
662,
63,
905
],
[
905,
4... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quazepam"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
],
... | Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Quazepam (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Estazolam and Estazolam (Compound) resembles Quazepam (Compound)
... |
DB06203 | DB12267 | 1,002 | 1,476 | [
"DDInter51",
"DDInter233"
] | Alogliptin | Brigatinib | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
1002,
24,
1476
]
],
[
[
1002,
63,
168
],
[
168,
23,
1476
]
],
[
[
1002,
63,
629
],
[
629,
24,
1476
]
],
[
[
1002,
24,
850
],
[
850,
... | [
[
[
"Alogliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Alogliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus... |
DB05294 | DB14568 | 1,069 | 982 | [
"DDInter1917",
"DDInter1000"
] | Vandetanib | Ivosidenib | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1069,
25,
982
]
],
[
[
1069,
62,
112
],
[
112,
23,
982
]
],
[
[
1069,
63,
543
],
[
543,
24,
982
]
],
[
[
1069,
24,
28
],
[
28,
2... | [
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Vandetanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Vandetanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Vandetanib may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Lope... |
DB00683 | DB08816 | 1,382 | 578 | [
"DDInter1212",
"DDInter1802"
] | Midazolam | Ticagrelor | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
1382,
24,
578
]
],
[
[
1382,
6,
4973
],
[
4973,
45,
578
]
],
[
[
1382,
21,
28646
],
[
28646,
60,
578
]
],
[
[
1382,
63,
723
],
[
723,
... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Midazolam",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Midazolam (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound)
Midazolam (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Midazolam may cause a modera... |
DB00215 | DB01001 | 1,230 | 688 | [
"DDInter388",
"DDInter1632"
] | Citalopram | Salbutamol | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1230,
24,
688
]
],
[
[
1230,
24,
455
],
[
455,
24,
688
]
],
[
[
1230,
25,
1148
],
[
1148,
63,
688
]
],
[
[
1230,
6,
8374
],
[
8374,
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Citalopram may lead to a major life threatening interaction when taken with Isoprenaline and Isoprenaline may ca... |
DB04855 | DB08875 | 540 | 1,618 | [
"DDInter602",
"DDInter262"
] | Dronedarone | Cabozantinib | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
540,
25,
1618
]
],
[
[
540,
25,
1135
],
[
1135,
62,
1618
]
],
[
[
540,
62,
112
],
[
112,
23,
1618
]
],
[
[
540,
63,
723
],
[
723,
... | [
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u}... | Dronedarone may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Dronedarone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may ca... |
DB00857 | DB04951 | 1,387 | 187 | [
"DDInter1768",
"DDInter1477"
] | Terbinafine | Pirfenidone | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Moderate | 1 | [
[
[
1387,
24,
187
]
],
[
[
1387,
62,
168
],
[
168,
23,
187
]
],
[
[
1387,
25,
1670
],
[
1670,
63,
187
]
],
[
[
1387,
24,
637
],
[
637,
... | [
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pirfenidone"
]
],
[
[
"Terbinafine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[
... | Terbinafine may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Pirfenidone
Terbinafine may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may cause a... |
DB00773 | DB11978 | 896 | 124 | [
"DDInter702",
"DDInter822"
] | Etoposide | Glasdegib | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
896,
24,
124
]
],
[
[
896,
24,
112
],
[
112,
23,
124
]
],
[
[
896,
24,
327
],
[
327,
24,
124
]
],
[
[
896,
63,
79
],
[
79,
24,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Abametapir and Abame... |
DB00039 | DB04865 | 1,253 | 4 | [
"DDInter1380",
"DDInter1335"
] | Palifermin | Omacetaxine mepesuccinate | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1253,
24,
4
]
],
[
[
1253,
24,
1394
],
[
1394,
24,
4
]
],
[
[
1253,
24,
1250
],
[
1250,
63,
4
]
],
[
[
1253,
63,
342
],
[
342,
2... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rituximab"
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Rituximab and Rituximab may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Pazopani... |
DB00909 | DB11837 | 306 | 1,297 | [
"DDInter1971",
"DDInter1351"
] | Zonisamide | Osilodrostat | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
306,
24,
1297
]
],
[
[
306,
24,
222
],
[
222,
23,
1297
]
],
[
[
306,
63,
353
],
[
353,
24,
1297
]
],
[
[
306,
25,
401
],
[
401,
... | [
[
[
"Zonisamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Zonisamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[... | Zonisamide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Zonisamide may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Gr... |
DB00539 | DB12500 | 11 | 283 | [
"DDInter1837",
"DDInter714"
] | Toremifene | Fedratinib | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
11,
24,
283
]
],
[
[
11,
25,
351
],
[
351,
23,
283
]
],
[
[
11,
24,
122
],
[
122,
23,
283
]
],
[
[
11,
24,
1339
],
[
1339,
62,
... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Ribociclib... | Toremifene may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Verapamil may cause a mi... |
DB00582 | DB06176 | 1,622 | 1,342 | [
"DDInter1946",
"DDInter1616"
] | Voriconazole | Romidepsin | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
1622,
24,
1342
]
],
[
[
1622,
23,
112
],
[
112,
23,
1342
]
],
[
[
1622,
24,
485
],
[
485,
24,
1342
]
],
[
[
1622,
24,
1616
],
[
1616,
... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Voriconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Voriconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and... |
DB00531 | DB00745 | 450 | 307 | [
"DDInter456",
"DDInter1236"
] | Cyclophosphamide | Modafinil | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Minor | 0 | [
[
[
450,
23,
307
]
],
[
[
450,
63,
362
],
[
362,
40,
307
]
],
[
[
450,
24,
1236
],
[
1236,
40,
307
]
],
[
[
450,
6,
10215
],
[
10215,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Modafinil (Compound)
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbamazepine (Compound) resembles Modafin... |
DB00754 | DB01024 | 157 | 1,096 | [
"DDInter696",
"DDInter1252"
] | Ethotoin | Mycophenolic acid | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Minor | 0 | [
[
[
157,
23,
1096
]
],
[
[
157,
7,
8924
],
[
8924,
46,
1096
]
],
[
[
157,
18,
2811
],
[
2811,
57,
1096
]
],
[
[
157,
21,
28684
],
[
28684,... | [
[
[
"Ethotoin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Ethotoin",
"{u} (Compound) upregulates {v} (Gene)",
"SPAG4"
],
[
"SPAG4",
"{u} (Gene) is upregulated by {v} (... | Ethotoin (Compound) upregulates SPAG4 (Gene) and SPAG4 (Gene) is upregulated by Mycophenolic acid (Compound)
Ethotoin (Compound) downregulates RRP1B (Gene) and RRP1B (Gene) is downregulated by Mycophenolic acid (Compound)
Ethotoin (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused b... |
DB00261 | DB00818 | 702 | 898 | [
"DDInter93",
"DDInter1538"
] | Anagrelide | Propofol | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Moderate | 1 | [
[
[
702,
24,
898
]
],
[
[
702,
6,
7950
],
[
7950,
45,
898
]
],
[
[
702,
21,
29789
],
[
29789,
60,
898
]
],
[
[
702,
24,
1031
],
[
1031,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propofol"
]
],
[
[
"Anagrelide",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Anagrelide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Propofol (Compound)
Anagrelide (Compound) causes Supraventricular tachycardia (Side Effect) and Supraventricular tachycardia (Side Effect) is caused by Propofol (Compound)
Anagrelide may cause a moderate interaction that could exacerbate diseases w... |
DB00333 | DB11817 | 576 | 1,259 | [
"DDInter1166",
"DDInter165"
] | Methadone | Baricitinib | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Moderate | 1 | [
[
[
576,
24,
1259
]
],
[
[
576,
25,
927
],
[
927,
24,
1259
]
],
[
[
576,
24,
407
],
[
407,
24,
1259
]
],
[
[
576,
64,
475
],
[
475,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baricitinib"
]
],
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encorafeni... | Methadone may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderat... |
DB00022 | DB01041 | 268 | 770 | [
"DDInter1408",
"DDInter1789"
] | Peginterferon alfa-2b | Thalidomide | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
268,
24,
770
]
],
[
[
268,
24,
4
],
[
4,
63,
770
]
],
[
[
268,
25,
876
],
[
876,
24,
770
]
],
[
[
268,
24,
453
],
[
453,
24,
... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omac... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Peginterferon alfa-2b may lead to a major life threatening interaction... |
DB00514 | DB01149 | 506 | 851 | [
"DDInter527",
"DDInter1274"
] | Dextromethorphan | Nefazodone | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Major | 2 | [
[
[
506,
25,
851
]
],
[
[
506,
24,
252
],
[
252,
40,
851
]
],
[
[
506,
24,
1178
],
[
1178,
1,
851
]
],
[
[
506,
25,
827
],
[
827,
40... | [
[
[
"Dextromethorphan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nefazodone"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],
[
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Nefazodone (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resemble... |
DB00635 | DB01045 | 1,573 | 463 | [
"DDInter1515",
"DDInter1590"
] | Prednisone | Rifampicin | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
1573,
24,
463
]
],
[
[
1573,
63,
690
],
[
690,
40,
463
]
],
[
[
1573,
6,
10215
],
[
10215,
45,
463
]
],
[
[
1573,
63,
1101
],
[
1101,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin (Compound) resembles Rifampicin (Compound)
Prednisone (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Rifampicin (Compound)
Prednisone may cause a moderate interaction that could exacerbate ... |
DB00976 | DB11979 | 1,056 | 1,320 | [
"DDInter1758",
"DDInter625"
] | Telithromycin | Elagolix | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Major | 2 | [
[
[
1056,
25,
1320
]
],
[
[
1056,
63,
168
],
[
168,
23,
1320
]
],
[
[
1056,
25,
1297
],
[
1297,
24,
1320
]
],
[
[
1056,
63,
79
],
[
79,
... | [
[
[
"Telithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Elagolix"
]
],
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bortez... | Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Telithromycin may lead to a major life threatening interaction when taken with Osilodrostat and Osilodrostat may ... |
DB00783 | DB11921 | 1,438 | 1,019 | [
"DDInter680",
"DDInter492"
] | Estradiol (topical) | Deflazacort | 17beta-estradiol is the 17beta-isomer of estradiol. It has a role as an estrogen, a human metabolite, an EC 1.2.3.1 (aldehyde oxidase) inhibitor, a Daphnia magna metabolite, a mouse metabolite and a geroprotector. It is a 17beta-hydroxy steroid and an estradiol. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1438,
24,
1019
]
],
[
[
1438,
24,
959
],
[
959,
24,
1019
]
],
[
[
1438,
24,
1619
],
[
1619,
63,
1019
]
],
[
[
1438,
1,
890
],
[
890,
... | [
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Estradiol ma... |
DB04865 | DB08913 | 4 | 1,186 | [
"DDInter1335",
"DDInter1561"
] | Omacetaxine mepesuccinate | Radium Ra 223 dichloride | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
4,
24,
1186
]
],
[
[
4,
63,
37
],
[
37,
24,
1186
]
],
[
[
4,
24,
1583
],
[
1583,
63,
1186
]
],
[
[
4,
24,
1491
],
[
1491,
24,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken w... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 dichloride
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate dise... |
DB00556 | DB01246 | 1,262 | 820 | [
"DDInter1429",
"DDInter45"
] | Perflutren | Alimemazine | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1262,
24,
820
]
],
[
[
1262,
24,
401
],
[
401,
24,
820
]
],
[
[
1262,
21,
28662
],
[
28662,
60,
820
]
],
[
[
1262,
24,
286
],
[
286,
... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[... | Perflutren may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Perflutren (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Alimemazine (Compou... |
DB01242 | DB04837 | 1,237 | 649 | [
"DDInter410",
"DDInter407"
] | Clomipramine | Clofedanol | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1237,
24,
649
]
],
[
[
1237,
63,
1376
],
[
1376,
24,
649
]
],
[
[
1237,
40,
21
],
[
21,
24,
649
]
],
[
[
1237,
1,
293
],
[
293,
... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],... | Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Clomipramine (Compound) resembles Amitriptyline (Compound) and Amitriptyline may cause a moderate in... |
DB01142 | DB01227 | 1,264 | 1,301 | [
"DDInter593",
"DDInter1043"
] | Doxepin | Levacetylmethadol | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Major | 2 | [
[
[
1264,
25,
1301
]
],
[
[
1264,
64,
494
],
[
494,
1,
1301
]
],
[
[
1264,
63,
307
],
[
307,
1,
1301
]
],
[
[
1264,
24,
649
],
[
649,
... | [
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levacetylmethadol"
]
],
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Disopyramide"
],
[
"Disopyramide",
"... | Doxepin may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) resembles Levacetylmethadol (Compound)
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil (Compound) resembles Levacetylmethadol (Compound)
Doxep... |
DB00030 | DB00364 | 1,685 | 417 | [
"DDInter934",
"DDInter1717"
] | Insulin human | Sucralfate | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia . It is considered a _cytoprotective agent_, protec... | Moderate | 1 | [
[
[
1685,
24,
417
]
],
[
[
1685,
24,
17
],
[
17,
62,
417
]
],
[
[
1685,
24,
1152
],
[
1152,
23,
417
]
],
[
[
1685,
24,
959
],
[
959,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralfate"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
],
[... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothy... |
DB11827 | DB14276 | 433 | 1,631 | [
"DDInter669",
"DDInter1892"
] | Ertugliflozin | Turmeric | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Moderate | 1 | [
[
[
433,
24,
1631
]
],
[
[
433,
63,
473
],
[
473,
24,
1631
]
],
[
[
433,
63,
473
],
[
473,
64,
1347
],
[
1347,
23,
1631
]
],
[
[
433,
... | [
[
[
"Ertugliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Turmeric"
]
],
[
[
"Ertugliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
],
... | Ertugliflozin may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Turmeric
Ertugliflozin may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and... |
DB05679 | DB14444 | 1,683 | 151 | [
"DDInter1907",
"DDInter924"
] | Ustekinumab | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1683,
24,
151
]
],
[
[
1683,
63,
66
],
[
66,
24,
151
]
],
[
[
1683,
24,
1619
],
[
1619,
24,
151
]
],
[
[
1683,
25,
375
],
[
375,
... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Ustekinumab may cause a moderate int... |
DB01005 | DB14711 | 995 | 779 | [
"DDInter894",
"DDInter1680"
] | Hydroxyurea | Smallpox (Vaccinia) Vaccine, Live | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
995,
25,
779
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],
[
[
995,
64,
1064
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[
1064,
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779
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[
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995,
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[
1377,
25,
779
]
],
[
[
995,
63,
147
],
[
147,
... | [
[
[
"Hydroxyurea",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Hydroxyurea",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"... | Hydroxyurea may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Hydroxyurea may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may lead to a... |
DB01006 | DB12332 | 300 | 1,619 | [
"DDInter1040",
"DDInter1626"
] | Letrozole | Rucaparib | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
300,
24,
1619
]
],
[
[
300,
62,
307
],
[
307,
23,
1619
]
],
[
[
300,
24,
1213
],
[
1213,
24,
1619
]
],
[
[
300,
63,
1438
],
[
1438,
... | [
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Letrozole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
"M... | Letrozole may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may ca... |
DB00620 | DB04834 | 175 | 276 | [
"DDInter1855",
"DDInter1571"
] | Triamcinolone | Rapacuronium | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm. | Moderate | 1 | [
[
[
175,
24,
276
]
],
[
[
175,
63,
1031
],
[
1031,
24,
276
]
],
[
[
175,
24,
1287
],
[
1287,
24,
276
]
],
[
[
175,
40,
251
],
[
251,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rapacuronium"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
]... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Rapacuronium
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Amphoteri... |
DB01037 | DB01612 | 1,161 | 1,637 | [
"DDInter1653",
"DDInter92"
] | Selegiline | Amyl Nitrite | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
1161,
24,
1637
]
],
[
[
1161,
24,
714
],
[
714,
24,
1637
]
],
[
[
1161,
63,
1061
],
[
1061,
24,
1637
]
],
[
[
1161,
25,
593
],
[
593,
... | [
[
[
"Selegiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Selegiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
],
[
... | Selegiline may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Selegiline may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Trepro... |
DB00005 | DB01024 | 1,057 | 1,096 | [
"DDInter687",
"DDInter1252"
] | Etanercept | Mycophenolic acid | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Major | 2 | [
[
[
1057,
25,
1096
]
],
[
[
1057,
25,
955
],
[
955,
1,
1096
]
],
[
[
1057,
23,
1193
],
[
1193,
62,
1096
]
],
[
[
1057,
24,
1031
],
[
1031,... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mycophenolate mofetil"
],
[
"Mycophe... | Etanercept may lead to a major life threatening interaction when taken with Mycophenolate mofetil and Mycophenolate mofetil (Compound) resembles Mycophenolic acid (Compound)
Etanercept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor inter... |
DB00515 | DB00609 | 589 | 595 | [
"DDInter387",
"DDInter694"
] | Cisplatin | Ethionamide | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | Moderate | 1 | [
[
[
589,
24,
595
]
],
[
[
589,
21,
28787
],
[
28787,
60,
595
]
],
[
[
589,
24,
372
],
[
372,
63,
595
]
],
[
[
589,
64,
1057
],
[
1057,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethionamide"
]
],
[
[
"Cisplatin",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is cau... | Cisplatin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Ethionamide (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Ethi... |
DB00572 | DB00733 | 85 | 1,666 | [
"DDInter136",
"DDInter1503"
] | Atropine | Pralidoxime | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. If given within 24 hours,after organophosphate exposure, pralidoxime reactivates the enzyme cholinesterase by cle... | Minor | 0 | [
[
[
85,
23,
1666
]
],
[
[
85,
21,
28719
],
[
28719,
60,
1666
]
],
[
[
85,
21,
28921
],
[
28921,
60,
1319
],
[
1319,
63,
1666
]
],
[
[
85,
... | [
[
[
"Atropine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pralidoxime"
]
],
[
[
"Atropine",
"{u} (Compound) causes {v} (Side Effect)",
"Pain"
],
[
"Pain",
"{u} (Side Effect) is caused by {v} (Comp... | Atropine (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Pralidoxime (Compound)
Atropine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Mivacurium (Compound) and Mivacurium may cause a moderate interaction that could exacerbate diseases when taken with Pralid... |
DB00585 | DB01416 | 1,127 | 1,024 | [
"DDInter1309",
"DDInter326"
] | Nizatidine | Cefpodoxime | A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. | Cefpodoxime is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime. | Moderate | 1 | [
[
[
1127,
24,
1024
]
],
[
[
1127,
24,
665
],
[
665,
40,
1024
]
],
[
[
1127,
24,
1462
],
[
1462,
1,
1024
]
],
[
[
1127,
21,
29814
],
[
2981... | [
[
[
"Nizatidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefpodoxime"
]
],
[
[
"Nizatidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefuroxime"
],
[
... | Nizatidine may cause a moderate interaction that could exacerbate diseases when taken with Cefuroxime and Cefuroxime (Compound) resembles Cefpodoxime (Compound)
Nizatidine may cause a moderate interaction that could exacerbate diseases when taken with Cefditoren and Cefditoren (Compound) resembles Cefpodoxime (Compound... |
DB01050 | DB12364 | 848 | 1,421 | [
"DDInter900",
"DDInter200"
] | Ibuprofen | Betrixaban | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
848,
25,
1421
]
],
[
[
848,
23,
297
],
[
297,
23,
1421
]
],
[
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848,
24,
1017
],
[
1017,
24,
1421
]
],
[
[
848,
63,
529
],
[
529,
... | [
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Ibuprofen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u} ... | Ibuprofen may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Betrixaban
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a... |
DB00705 | DB04951 | 441 | 187 | [
"DDInter496",
"DDInter1477"
] | Delavirdine | Pirfenidone | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Moderate | 1 | [
[
[
441,
24,
187
]
],
[
[
441,
63,
168
],
[
168,
23,
187
]
],
[
[
441,
25,
1670
],
[
1670,
63,
187
]
],
[
[
441,
63,
1419
],
[
1419,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pirfenidone"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Pirfenidone
Delavirdine may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may cause... |
DB00188 | DB00607 | 168 | 1,249 | [
"DDInter222",
"DDInter1256"
] | Bortezomib | Nafcillin | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Minor | 0 | [
[
[
168,
23,
1249
]
],
[
[
168,
6,
7950
],
[
7950,
45,
1249
]
],
[
[
168,
18,
4360
],
[
4360,
57,
1249
]
],
[
[
168,
21,
28792
],
[
28792,... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nafcillin"
]
],
[
[
"Bortezomib",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Bortezomib (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nafcillin (Compound)
Bortezomib (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Nafcillin (Compound)
Bortezomib (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caus... |
DB00776 | DB01058 | 1,335 | 978 | [
"DDInter1360",
"DDInter1510"
] | Oxcarbazepine | Praziquantel | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infecti... | Moderate | 1 | [
[
[
1335,
24,
978
]
],
[
[
1335,
6,
7524
],
[
7524,
45,
978
]
],
[
[
1335,
21,
28709
],
[
28709,
60,
978
]
],
[
[
1335,
63,
510
],
[
510,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Praziquantel"
]
],
[
[
"Oxcarbazepine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Com... | Oxcarbazepine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Praziquantel (Compound)
Oxcarbazepine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Praziquantel (Compound)
Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when... |
DB00180 | DB00938 | 1,351 | 455 | [
"DDInter749",
"DDInter1635"
] | Flunisolide | Salmeterol | Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid with anti-inflammatory actions. It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves activation of glucocorticoid receptors. | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Minor | 0 | [
[
[
1351,
23,
455
]
],
[
[
1351,
23,
688
],
[
688,
63,
455
]
],
[
[
1351,
5,
11649
],
[
11649,
44,
455
]
],
[
[
1351,
6,
8374
],
[
8374,
... | [
[
[
"Flunisolide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Salmeterol"
]
],
[
[
"Flunisolide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Salbutamol"
],
[
... | Flunisolide may cause a minor interaction that can limit clinical effects when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Flunisolide (Compound) treats asthma (Disease) and asthma (Disease) is treated by Salmeterol (Compound)
Flunisoli... |
DB00861 | DB01276 | 914 | 123 | [
"DDInter551",
"DDInter706"
] | Diflunisal | Exenatide | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
914,
24,
123
]
],
[
[
914,
63,
1573
],
[
1573,
24,
123
]
],
[
[
914,
24,
1039
],
[
1039,
24,
123
]
],
[
[
914,
64,
126
],
[
126,
... | [
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and De... |
DB00880 | DB09156 | 359 | 777 | [
"DDInter360",
"DDInter964"
] | Chlorothiazide | Iopromide | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Moderate | 1 | [
[
[
359,
24,
777
]
],
[
[
359,
63,
1648
],
[
1648,
24,
777
]
],
[
[
359,
40,
674
],
[
674,
24,
777
]
],
[
[
359,
63,
1512
],
[
1512,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
]
],
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
... | Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Chlorothiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a modera... |
DB08870 | DB15762 | 850 | 725 | [
"DDInter228",
"DDInter1644"
] | Brentuximab vedotin | Satralizumab | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare au... | Moderate | 1 | [
[
[
850,
24,
725
]
],
[
[
850,
24,
1362
],
[
1362,
24,
725
]
],
[
[
850,
63,
372
],
[
372,
24,
725
]
],
[
[
850,
64,
1066
],
[
1066,
... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Satralizumab"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olapari... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Clofa... |
DB09156 | DB14598 | 777 | 183 | [
"DDInter964",
"DDInter619"
] | Iopromide | Edetate calcium disodium anhydrous | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Edetate calcium disodium is a metal ion chelator used to reduce blood concentrations and depot stores of lead from the body. It is on the World Health Organization Model List of Essential Medicines. Edetate calcium disodium was granted FDA approval on 16 July 1953. | Major | 2 | [
[
[
777,
25,
183
]
],
[
[
777,
64,
372
],
[
372,
24,
183
]
],
[
[
777,
64,
789
],
[
789,
24,
372
],
[
372,
24,
183
]
],
[
[
777,
64,... | [
[
[
"Iopromide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edetate calcium disodium anhydrous"
]
],
[
[
"Iopromide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clofarabine"
],
[
"Cl... | Iopromide may lead to a major life threatening interaction when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Edetate calcium disodium anhydrous
Iopromide may lead to a major life threatening interaction when taken with Foscarnet and Foscarnet may... |
DB08880 | DB12010 | 1,510 | 214 | [
"DDInter1771",
"DDInter785"
] | Teriflunomide | Fostamatinib | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Major | 2 | [
[
[
1510,
25,
214
]
],
[
[
1510,
25,
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],
[
976,
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]
],
[
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866
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[
866,
24,
214
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],
[
[
1510,
63,
10
],
[
10,
2... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitinib",
... | Teriflunomide may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Teriflunomide may lead to a major life threatening interaction when taken with Cobimetinib and Cobimetinib may cause a m... |
DB00053 | DB00419 | 1,658 | 1,625 | [
"DDInter910",
"DDInter1218"
] | Imiglucerase | Miglustat | Human Beta-glucocerebrosidase or Beta-D-glucosyl-N-acylsphingosine glucohydrolase E.C. 3.2.1.45. 497 residue protein with N-linked carbohydrates, MW=59.3 kD. Alglucerase is prepared by modification of the oligosaccharide chains of human Beta-glucocerebrosidase. The modification alters the sugar residues at the non-redu... | Miglustat, commonly marketed under the trade name Zavesca, is a drug used to treat Gaucher disease. It inhibits the enzyme glucosylceramide synthase, an essential enzyme for the synthesis of most glycosphingolipids. It is only used for patients who cannot be treated with enzyme replacement therapy with imiglucerase. Mi... | Moderate | 1 | [
[
[
1658,
24,
1625
]
]
] | [
[
[
"Imiglucerase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglustat"
]
]
] | |
DB00673 | DB00909 | 723 | 306 | [
"DDInter112",
"DDInter1971"
] | Aprepitant | Zonisamide | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Moderate | 1 | [
[
[
723,
24,
306
]
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[
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723,
6,
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[
8374,
45,
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]
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[
[
723,
21,
28691
],
[
28691,
60,
306
]
],
[
[
723,
24,
159
],
[
159,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zonisamide"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Aprepitant (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zonisamide (Compound)
Aprepitant (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Zonisamide (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and... |
DB00831 | DB01344 | 1,178 | 1,231 | [
"DDInter1866",
"DDInter1830"
] | Trifluoperazine | Tolevamer | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Moderate | 1 | [
[
[
1178,
24,
1231
]
],
[
[
1178,
62,
417
],
[
417,
24,
1231
]
],
[
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63,
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],
[
870,
24,
1231
]
],
[
[
1178,
24,
603
],
[
603,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolevamer"
]
],
[
[
"Trifluoperazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sucralfate"
],
... | Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate and Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortison... |
DB00470 | DB12130 | 530 | 1,017 | [
"DDInter601",
"DDInter1094"
] | Dronabinol | Lorlatinib | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
530,
24,
1017
]
],
[
[
530,
24,
409
],
[
409,
24,
1017
]
],
[
[
530,
63,
556
],
[
556,
24,
1017
]
],
[
[
530,
24,
1654
],
[
1654,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Felodipine and Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Valproic acid and Val... |
DB00619 | DB11732 | 1,419 | 1,097 | [
"DDInter909",
"DDInter1027"
] | Imatinib | Lasmiditan | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
1419,
24,
1097
]
],
[
[
1419,
63,
1181
],
[
1181,
24,
1097
]
],
[
[
1419,
24,
971
],
[
971,
63,
1097
]
],
[
[
1419,
24,
77
],
[
77,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terfenadine"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Terfenadine and Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilter... |
DB00006 | DB00500 | 942 | 24 | [
"DDInter217",
"DDInter1831"
] | Bivalirudin | Tolmetin | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Moderate | 1 | [
[
[
942,
24,
24
]
],
[
[
942,
24,
886
],
[
886,
1,
24
]
],
[
[
942,
24,
831
],
[
831,
40,
24
]
],
[
[
942,
24,
1432
],
[
1432,
24,
... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolmetin"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketorolac"
],
[
... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac (Compound) resembles Tolmetin (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) resembles Tolmetin (Compound)
... |
DB00289 | DB00397 | 847 | 1,466 | [
"DDInter132",
"DDInter1458"
] | Atomoxetine | Phenylpropanolamine | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Moderate | 1 | [
[
[
847,
24,
1466
]
],
[
[
847,
6,
7390
],
[
7390,
45,
1466
]
],
[
[
847,
21,
28717
],
[
28717,
60,
1466
]
],
[
[
847,
24,
1662
],
[
1662,... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylpropanolamine"
]
],
[
[
"Atomoxetine",
"{u} (Compound) binds {v} (Gene)",
"SLC6A2"
],
[
"SLC6A2",
"{u} (Gene) is bound by {v} (... | Atomoxetine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Phenylpropanolamine (Compound)
Atomoxetine (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Phenylpropanolamine (Compound)
Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB12095 | DB13074 | 179 | 877 | [
"DDInter1760",
"DDInter1110"
] | Telotristat ethyl | Macimorelin | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
179,
24,
877
]
],
[
[
179,
63,
1320
],
[
1320,
24,
877
]
],
[
[
179,
64,
966
],
[
966,
24,
877
]
],
[
[
179,
25,
1476
],
[
1476,
... | [
[
[
"Telotristat ethyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Telotristat ethyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
... | Telotristat ethyl may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin
Telotristat ethyl may lead to a major life threatening interaction when taken with Octreotide and Octreotide... |
DB00461 | DB09075 | 598 | 498 | [
"DDInter1254",
"DDInter621"
] | Nabumetone | Edoxaban | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
598,
25,
498
]
],
[
[
598,
24,
222
],
[
222,
24,
498
]
],
[
[
598,
24,
738
],
[
738,
63,
498
]
],
[
[
598,
63,
305
],
[
305,
24,... | [
[
[
"Nabumetone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutramine... | Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Nirapar... |
DB00288 | DB01261 | 1,103 | 170 | [
"DDInter63",
"DDInter1679"
] | Amcinonide | Sitagliptin | Amcinonide is a corticosteroid. | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Minor | 0 | [
[
[
1103,
23,
170
]
],
[
[
1103,
18,
2683
],
[
2683,
57,
170
]
],
[
[
1103,
21,
28787
],
[
28787,
60,
170
]
],
[
[
1103,
23,
52
],
[
52,
... | [
[
[
"Amcinonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sitagliptin"
]
],
[
[
"Amcinonide",
"{u} (Compound) downregulates {v} (Gene)",
"DFFA"
],
[
"DFFA",
"{u} (Gene) is downregulated by {v} (... | Amcinonide (Compound) downregulates DFFA (Gene) and DFFA (Gene) is downregulated by Sitagliptin (Compound)
Amcinonide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Sitagliptin (Compound)
Amcinonide may cause a minor interaction that can limit clinical effects when taken with Dulag... |
DB01168 | DB10276 | 1,053 | 1,624 | [
"DDInter1526",
"DDInter1623"
] | Procarbazine | Rotavirus vaccine | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
1053,
25,
1624
]
],
[
[
1053,
63,
1648
],
[
1648,
25,
1624
]
],
[
[
1053,
64,
770
],
[
770,
25,
1624
]
],
[
[
1053,
25,
375
],
[
375,
... | [
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may lead to a major life threatening interaction when taken with Rotavirus vaccine
Procarbazine may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may lead t... |
DB00681 | DB00798 | 1,287 | 1,132 | [
"DDInter85",
"DDInter815"
] | Amphotericin B | Gentamicin | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Moderate | 1 | [
[
[
1287,
24,
1132
]
],
[
[
1287,
21,
28703
],
[
28703,
60,
1132
]
],
[
[
1287,
63,
1252
],
[
1252,
23,
1132
]
],
[
[
1287,
24,
361
],
[
3... | [
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gentamicin"
]
],
[
[
"Amphotericin B",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) i... | Amphotericin B (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Gentamicin (Compound)
Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Gentamici... |
DB01018 | DB14568 | 1,364 | 982 | [
"DDInter847",
"DDInter1000"
] | Guanfacine | Ivosidenib | Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approva... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
1364,
24,
982
]
],
[
[
1364,
63,
1101
],
[
1101,
23,
982
]
],
[
[
1364,
24,
976
],
[
976,
24,
982
]
],
[
[
1364,
24,
159
],
[
159,
... | [
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacit... |
DB00014 | DB00489 | 521 | 17 | [
"DDInter839",
"DDInter1704"
] | Goserelin | Sotalol | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Major | 2 | [
[
[
521,
25,
17
]
],
[
[
521,
25,
347
],
[
347,
40,
17
]
],
[
[
521,
21,
28719
],
[
28719,
60,
17
]
],
[
[
521,
23,
112
],
[
112,
62... | [
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sotalol"
]
],
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibutilide"
],
[
"Ibutilide",
"{u} (Compoun... | Goserelin may lead to a major life threatening interaction when taken with Ibutilide and Ibutilide (Compound) resembles Sotalol (Compound)
Goserelin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Sotalol (Compound)
Goserelin may cause a minor interaction that can limit clinical effects when ta... |
DB11160 | DB14740 | 337 | 771 | [
"DDInter1459",
"DDInter881"
] | Phenyltoloxamine | Hyaluronidase | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
337,
23,
771
]
],
[
[
337,
63,
849
],
[
849,
23,
771
]
],
[
[
337,
63,
849
],
[
849,
63,
1242
],
[
1242,
23,
771
]
],
[
[
337,
6... | [
[
[
"Phenyltoloxamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Phenyltoloxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
... | Phenyltoloxamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Phenyltoloxamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyrami... |
DB00196 | DB11730 | 600 | 351 | [
"DDInter743",
"DDInter1588"
] | Fluconazole | Ribociclib | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
600,
25,
351
]
],
[
[
600,
23,
271
],
[
271,
23,
351
]
],
[
[
600,
23,
466
],
[
466,
62,
351
]
],
[
[
600,
24,
283
],
[
283,
62,... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"Mirabegron... | Fluconazole may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Daroluta... |
DB00457 | DB00852 | 1,205 | 1,445 | [
"DDInter1511",
"DDInter1545"
] | Prazosin | Pseudoephedrine | Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988. It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTS... | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Moderate | 1 | [
[
[
1205,
24,
1445
]
],
[
[
1205,
6,
5214
],
[
5214,
45,
1445
]
],
[
[
1205,
21,
28956
],
[
28956,
60,
1445
]
],
[
[
1205,
24,
1344
],
[
1... | [
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
]
],
[
[
"Prazosin",
"{u} (Compound) binds {v} (Gene)",
"ADRA1A"
],
[
"ADRA1A",
"{u} (Gene) is bound by {v} (Compound)"... | Prazosin (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is bound by Pseudoephedrine (Compound)
Prazosin (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Pseudoephedrine (Compound)
Prazosin may cause a moderate interaction that could exacerbate diseases when taken with Canaglifl... |
DB00224 | DB00307 | 215 | 1,101 | [
"DDInter917",
"DDInter202"
] | Indinavir | Bexarotene | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Moderate | 1 | [
[
[
215,
24,
1101
]
],
[
[
215,
6,
8374
],
[
8374,
45,
1101
]
],
[
[
215,
21,
28762
],
[
28762,
60,
1101
]
],
[
[
215,
24,
353
],
[
353,
... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
]
],
[
[
"Indinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Indinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bexarotene (Compound)
Indinavir (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Bexarotene (Compound)
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseof... |
DB01100 | DB01181 | 1,568 | 1,532 | [
"DDInter1470",
"DDInter906"
] | Pimozide | Ifosfamide | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
1568,
24,
1532
]
],
[
[
1568,
6,
7524
],
[
7524,
45,
1532
]
],
[
[
1568,
18,
2976
],
[
2976,
57,
1532
]
],
[
[
1568,
21,
28956
],
[
28... | [
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Pimozide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
... | Pimozide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ifosfamide (Compound)
Pimozide (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Ifosfamide (Compound)
Pimozide (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Pi... |
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