drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01067 | DB01268 | 959 | 1,151 | [
"DDInter826",
"DDInter1731"
] | Glipizide | Sunitinib | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
959,
24,
1151
]
],
[
[
959,
6,
8374
],
[
8374,
45,
1151
]
],
[
[
959,
18,
20027
],
[
20027,
46,
1151
]
],
[
[
959,
7,
6314
],
[
6314,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Glipizide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Glipizide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sunitinib (Compound)
Glipizide (Compound) downregulates LRP10 (Gene) and LRP10 (Gene) is upregulated by Sunitinib (Compound)
Glipizide (Compound) upregulates TLR4 (Gene) and TLR4 (Gene) is upregulated by Sunitinib (Compound)
Glipizide (Compound) dow... |
DB00927 | DB01050 | 1,559 | 848 | [
"DDInter712",
"DDInter900"
] | Famotidine | Ibuprofen | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Minor | 0 | [
[
[
1559,
23,
848
]
],
[
[
1559,
6,
16560
],
[
16560,
45,
848
]
],
[
[
1559,
21,
28841
],
[
28841,
60,
848
]
],
[
[
1559,
63,
62
],
[
62,
... | [
[
[
"Famotidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ibuprofen"
]
],
[
[
"Famotidine",
"{u} (Compound) binds {v} (Gene)",
"SLC22A8"
],
[
"SLC22A8",
"{u} (Gene) is bound by {v} (Compound)",
... | Famotidine (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Ibuprofen (Compound)
Famotidine (Compound) causes Bronchospasm (Side Effect) and Bronchospasm (Side Effect) is caused by Ibuprofen (Compound)
Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Tacrine and T... |
DB00208 | DB00620 | 1,018 | 175 | [
"DDInter1804",
"DDInter1855"
] | Ticlopidine | Triamcinolone | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Minor | 0 | [
[
[
1018,
23,
175
]
],
[
[
1018,
23,
1573
],
[
1573,
1,
175
]
],
[
[
1018,
6,
8374
],
[
8374,
45,
175
]
],
[
[
1018,
21,
28762
],
[
28762,... | [
[
[
"Ticlopidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Triamcinolone"
]
],
[
[
"Ticlopidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prednisone"
],
[
... | Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Ticlopidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Triamcinolone (Compound)
Ticlopidine (Compound) causes Headache (Side Effect) and Hea... |
DB00529 | DB06663 | 789 | 1,154 | [
"DDInter779",
"DDInter1398"
] | Foscarnet | Pasireotide | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
789,
25,
1154
]
],
[
[
789,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
789,
23,
112
],
[
112,
23,
1154
]
],
[
[
789,
24,
1662
],
[
1662,
... | [
[
[
"Foscarnet",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Foscarnet",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused by ... | Foscarnet (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Foscarnet may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken w... |
DB00976 | DB11978 | 1,056 | 124 | [
"DDInter1758",
"DDInter822"
] | Telithromycin | Glasdegib | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
1056,
25,
124
]
],
[
[
1056,
25,
1135
],
[
1135,
23,
124
]
],
[
[
1056,
62,
112
],
[
112,
23,
124
]
],
[
[
1056,
24,
466
],
[
466,
... | [
[
[
"Telithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Telithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u... | Telithromycin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Telithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may c... |
DB00283 | DB00915 | 701 | 1,170 | [
"DDInter395",
"DDInter60"
] | Clemastine | Amantadine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesi... | Moderate | 1 | [
[
[
701,
24,
1170
]
],
[
[
701,
21,
28662
],
[
28662,
60,
1170
]
],
[
[
701,
24,
1219
],
[
1219,
24,
1170
]
],
[
[
701,
24,
1532
],
[
1532... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amantadine"
]
],
[
[
"Clemastine",
"{u} (Compound) causes {v} (Side Effect)",
"Tremor"
],
[
"Tremor",
"{u} (Side Effect) is caused by ... | Clemastine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Amantadine (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Amantadine
Clem... |
DB05812 | DB11560 | 1,374 | 1,678 | [
"DDInter8",
"DDInter1038"
] | Abiraterone | Lesinurad | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter assoc... | Moderate | 1 | [
[
[
1374,
24,
1678
]
],
[
[
1374,
23,
466
],
[
466,
63,
1678
]
],
[
[
1374,
25,
877
],
[
877,
63,
1678
]
],
[
[
1374,
63,
79
],
[
79,
... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lesinurad"
]
],
[
[
"Abiraterone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
... | Abiraterone may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Lesinurad
Abiraterone may lead to a major life threatening interaction when taken with Macimorelin and Macimorelin may c... |
DB09331 | DB14783 | 745 | 287 | [
"DDInter478",
"DDInter574"
] | Daratumumab | Diroximel fumarate | Daratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of its kind. Daratumumab was granted FDA approval on 16 November 2015. It is approved for the trea... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
745,
24,
287
]
],
[
[
745,
63,
384
],
[
384,
24,
287
]
],
[
[
745,
24,
270
],
[
270,
24,
287
]
],
[
[
745,
64,
1510
],
[
1510,
2... | [
[
[
"Daratumumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Daratumumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]... | Daratumumab may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Daratumumab may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab... |
DB00366 | DB01075 | 1,594 | 1,376 | [
"DDInter600",
"DDInter569"
] | Doxylamine | Diphenhydramine | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1594,
24,
1376
]
],
[
[
1594,
24,
649
],
[
649,
63,
1376
]
],
[
[
1594,
40,
11
],
[
11,
1,
1376
]
],
[
[
1594,
35,
128
],
[
128,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Doxylamine (Compound) resembles Toremifene (Compound) and Toremifene (Compound) resembles Diphenhydramine (... |
DB01076 | DB11767 | 700 | 1,583 | [
"DDInter133",
"DDInter1643"
] | Atorvastatin | Sarilumab | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
700,
24,
1583
]
],
[
[
700,
63,
267
],
[
267,
24,
1583
]
],
[
[
700,
24,
850
],
[
850,
24,
1583
]
],
[
[
700,
62,
303
],
[
303,
... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
[... | Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedoti... |
DB00741 | DB08868 | 167 | 1,011 | [
"DDInter885",
"DDInter737"
] | Hydrocortisone | Fingolimod | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
167,
25,
1011
]
],
[
[
167,
6,
8374
],
[
8374,
45,
1011
]
],
[
[
167,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
167,
24,
61
],
[
61,
... | [
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Hydrocortisone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Hydrocortisone (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00850 | DB06691 | 1,630 | 849 | [
"DDInter1432",
"DDInter1155"
] | Perphenazine | Mepyramine | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1630,
24,
849
]
],
[
[
1630,
63,
1594
],
[
1594,
24,
849
]
],
[
[
1630,
24,
272
],
[
272,
24,
849
]
],
[
[
1630,
6,
12523
],
[
12523,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine ... |
DB00197 | DB00358 | 1,324 | 1,010 | [
"DDInter1881",
"DDInter1140"
] | Troglitazone | Mefloquine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Moderate | 1 | [
[
[
1324,
24,
1010
]
],
[
[
1324,
24,
392
],
[
392,
63,
1010
]
],
[
[
1324,
23,
1612
],
[
1612,
63,
1010
]
],
[
[
1324,
63,
521
],
[
521,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
[... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Fostemsavir and Foste... |
DB00502 | DB00981 | 1,300 | 1,528 | [
"DDInter853",
"DDInter1462"
] | Haloperidol | Physostigmine | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
1300,
24,
1528
]
],
[
[
1300,
21,
28751
],
[
28751,
60,
1528
]
],
[
[
1300,
24,
1511
],
[
1511,
63,
1528
]
],
[
[
1300,
24,
543
],
[
5... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Haloperidol",
"{u} (Compound) causes {v} (Side Effect)",
"Convulsion"
],
[
"Convulsion",
"{u} (Side Effect) ... | Haloperidol (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Physostigmine (Compound)
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00624 | DB06589 | 1,561 | 1,250 | [
"DDInter1775",
"DDInter1400"
] | Testosterone | Pazopanib | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Major | 2 | [
[
[
1561,
25,
1250
]
],
[
[
1561,
6,
3486
],
[
3486,
45,
1250
]
],
[
[
1561,
7,
4759
],
[
4759,
46,
1250
]
],
[
[
1561,
18,
12821
],
[
128... | [
[
[
"Testosterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pazopanib"
]
],
[
[
"Testosterone",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"Pazo... | Testosterone (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Pazopanib (Compound)
Testosterone (Compound) upregulates SERPINA3 (Gene) and SERPINA3 (Gene) is upregulated by Pazopanib (Compound)
Testosterone (Compound) downregulates TRIB1 (Gene) and TRIB1 (Gene) is downregulated by Pazopanib (Compound)
Testo... |
DB01020 | DB11827 | 1,107 | 433 | [
"DDInter990",
"DDInter669"
] | Isosorbide mononitrate | Ertugliflozin | Isosorbide mononitrate is an organic nitrate with vasodilating properties. It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload.[L11698, L11743] Isosorbide mononitrate is an active metabolite of [isosorbide dinitrate]. Li... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1107,
24,
433
]
],
[
[
1107,
24,
820
],
[
820,
24,
433
]
],
[
[
1107,
63,
999
],
[
999,
24,
433
]
],
[
[
1107,
1,
426
],
[
426,
... | [
[
[
"Isosorbide mononitrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Isosorbide mononitrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Isosorbide mononitrate may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Isosorbide mononitrate may cause a moderate interaction that could exacerbate diseases when tak... |
DB00197 | DB09080 | 1,324 | 144 | [
"DDInter1881",
"DDInter1331"
] | Troglitazone | Olodaterol | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
1324,
24,
144
]
],
[
[
1324,
24,
956
],
[
956,
24,
144
]
],
[
[
1324,
24,
1399
],
[
1399,
63,
144
]
],
[
[
1324,
63,
521
],
[
521,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbona... |
DB00903 | DB06335 | 1,680 | 761 | [
"DDInter686",
"DDInter1646"
] | Etacrynic acid | Saxagliptin | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1680,
24,
761
]
],
[
[
1680,
21,
28722
],
[
28722,
60,
761
]
],
[
[
1680,
63,
104
],
[
104,
24,
761
]
],
[
[
1680,
24,
1296
],
[
1296,... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Etacrynic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is c... | Etacrynic acid (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00594 | DB11057 | 863 | 720 | [
"DDInter68",
"DDInter1223"
] | Amiloride | Mineral oil | A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
863,
24,
720
]
],
[
[
863,
24,
175
],
[
175,
24,
720
]
],
[
[
863,
24,
1019
],
[
1019,
63,
720
]
],
[
[
863,
63,
355
],
[
355,
2... | [
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[
... | Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and ... |
DB00539 | DB00726 | 11 | 1,164 | [
"DDInter1837",
"DDInter1876"
] | Toremifene | Trimipramine | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Major | 2 | [
[
[
11,
25,
1164
]
],
[
[
11,
25,
1237
],
[
1237,
40,
1164
]
],
[
[
11,
1,
939
],
[
939,
40,
1164
]
],
[
[
11,
64,
508
],
[
508,
40,... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trimipramine"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clomipramine"
],
[
"Clomipramine",
... | Toremifene may lead to a major life threatening interaction when taken with Clomipramine and Clomipramine (Compound) resembles Trimipramine (Compound)
Toremifene (Compound) resembles Benzphetamine (Compound) and Benzphetamine (Compound) resembles Trimipramine (Compound)
Toremifene may lead to a major life threatening i... |
DB00218 | DB08868 | 1,176 | 1,011 | [
"DDInter1247",
"DDInter737"
] | Moxifloxacin | Fingolimod | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1176,
25,
1011
]
],
[
[
1176,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
1176,
23,
112
],
[
112,
23,
1011
]
],
[
[
1176,
24,
144
],
[
144... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac arrest"
],
[
"Cardiac arrest",
"{u} (Side Effect) is cause... | Moxifloxacin (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when ta... |
DB01254 | DB09020 | 1,213 | 28 | [
"DDInter484",
"DDInter212"
] | Dasatinib | Bisacodyl | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1213,
24,
28
]
],
[
[
1213,
18,
20113
],
[
20113,
46,
28
]
],
[
[
1213,
6,
9842
],
[
9842,
46,
28
]
],
[
[
1213,
7,
3361
],
[
3361,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Dasatinib",
"{u} (Compound) downregulates {v} (Gene)",
"IER3"
],
[
"IER3",
"{u} (Gene) is upregulated by {v} (Comp... | Dasatinib (Compound) downregulates IER3 (Gene) and IER3 (Gene) is upregulated by Bisacodyl (Compound)
Dasatinib (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is upregulated by Bisacodyl (Compound)
Dasatinib (Compound) upregulates NFIL3 (Gene) and NFIL3 (Gene) is upregulated by Bisacodyl (Compound)
Dasatinib (Compoun... |
DB01126 | DB09054 | 1,260 | 384 | [
"DDInter611",
"DDInter905"
] | Dutasteride | Idelalisib | Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestos... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1260,
24,
384
]
],
[
[
1260,
63,
600
],
[
600,
24,
384
]
],
[
[
1260,
24,
1619
],
[
1619,
63,
384
]
],
[
[
1260,
24,
609
],
[
609,
... | [
[
[
"Dutasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Dutasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[... | Dutasteride may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Dutasteride may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Ruc... |
DB00352 | DB01406 | 482 | 984 | [
"DDInter1814",
"DDInter472"
] | Tioguanine | Danazol | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Moderate | 1 | [
[
[
482,
24,
984
]
],
[
[
482,
24,
1546
],
[
1546,
1,
984
]
],
[
[
482,
24,
1026
],
[
1026,
40,
984
]
],
[
[
482,
21,
28784
],
[
28784,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danazol"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
],
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Danazol (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Oxandrolone and Oxandrolone (Compound) resembles Danazol... |
DB06168 | DB10315 | 1,531 | 1,137 | [
"DDInter281",
"DDInter1127"
] | Canakinumab | Measles virus vaccine live attenuated | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
1531,
25,
1137
]
],
[
[
1531,
63,
1042
],
[
1042,
24,
1137
]
],
[
[
1531,
24,
119
],
[
119,
64,
1137
]
],
[
[
1531,
63,
273
],
[
273,
... | [
[
[
"Canakinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactid... | Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide and Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Measles virus vaccine live attenuated
Canakinumab may cause a moderate interaction that could exacerbate diseases ... |
DB00047 | DB01175 | 176 | 318 | [
"DDInter932",
"DDInter672"
] | Insulin glargine | Escitalopram | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Moderate | 1 | [
[
[
176,
24,
318
]
],
[
[
176,
24,
1230
],
[
1230,
1,
318
]
],
[
[
176,
24,
168
],
[
168,
23,
318
]
],
[
[
176,
24,
999
],
[
999,
24... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction... |
DB09098 | DB11978 | 98 | 124 | [
"DDInter1700",
"DDInter822"
] | Somatrem | Glasdegib | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate. Such discussion revolves around whether patients' natural dispo... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
98,
24,
124
]
],
[
[
98,
63,
1135
],
[
1135,
23,
124
]
],
[
[
98,
24,
466
],
[
466,
62,
124
]
],
[
[
98,
63,
79
],
[
79,
24,
... | [
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
"N... | Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide ... |
DB00379 | DB05679 | 143 | 1,683 | [
"DDInter1206",
"DDInter1907"
] | Mexiletine | Ustekinumab | Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
143,
24,
1683
]
],
[
[
143,
24,
1093
],
[
1093,
63,
1683
]
],
[
[
143,
24,
478
],
[
478,
24,
1683
]
],
[
[
143,
63,
608
],
[
608,
... | [
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
],
[
... | Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab and Ixekizumab may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Niloti... |
DB00209 | DB00321 | 352 | 21 | [
"DDInter1886",
"DDInter78"
] | Trospium | Amitriptyline | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Moderate | 1 | [
[
[
352,
24,
21
]
],
[
[
352,
24,
1237
],
[
1237,
40,
21
]
],
[
[
352,
24,
1164
],
[
1164,
1,
21
]
],
[
[
352,
6,
7992
],
[
7992,
45... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amitriptyline"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Amitriptyline (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Amitriptyline (... |
DB00951 | DB04845 | 1,072 | 309 | [
"DDInter986",
"DDInter1001"
] | Isoniazid | Ixabepilone | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
1072,
24,
309
]
],
[
[
1072,
6,
8374
],
[
8374,
45,
309
]
],
[
[
1072,
21,
29518
],
[
29518,
60,
309
]
],
[
[
1072,
24,
1434
],
[
1434... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Isoniazid",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Isoniazid (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Isoniazid (Compound) causes Neurotoxicity (Side Effect) and Neurotoxicity (Side Effect) is caused by Ixabepilone (Compound)
Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole... |
DB00529 | DB01166 | 789 | 477 | [
"DDInter779",
"DDInter379"
] | Foscarnet | Cilostazol | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
789,
24,
477
]
],
[
[
789,
21,
28892
],
[
28892,
60,
477
]
],
[
[
789,
23,
112
],
[
112,
23,
477
]
],
[
[
789,
24,
820
],
[
820,
... | [
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Foscarnet",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac arrest"
],
[
"Cardiac arrest",
"{u} (Side Effect)... | Foscarnet (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Cilostazol (Compound)
Foscarnet may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken wi... |
DB06810 | DB11817 | 397 | 1,259 | [
"DDInter1484",
"DDInter165"
] | Plicamycin | Baricitinib | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
397,
25,
1259
]
],
[
[
397,
63,
1461
],
[
1461,
23,
1259
]
],
[
[
397,
63,
1274
],
[
1274,
24,
1259
]
],
[
[
397,
24,
949
],
[
949,
... | [
[
[
"Plicamycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Plicamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Plicamycin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Plicamycin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbip... |
DB01403 | DB11113 | 9 | 657 | [
"DDInter1175",
"DDInter307"
] | Methotrimeprazine | Castor oil | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
9,
24,
657
]
],
[
[
9,
24,
927
],
[
927,
63,
657
]
],
[
[
9,
24,
1491
],
[
1491,
24,
657
]
],
[
[
9,
25,
985
],
[
985,
24,
... | [
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
... | Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Midos... |
DB00364 | DB11799 | 417 | 627 | [
"DDInter1717",
"DDInter205"
] | Sucralfate | Bictegravir | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet. | Major | 2 | [
[
[
417,
25,
627
]
],
[
[
417,
24,
1130
],
[
1130,
24,
627
]
],
[
[
417,
63,
1324
],
[
1324,
24,
627
]
],
[
[
417,
24,
115
],
[
115,
... | [
[
[
"Sucralfate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bictegravir"
]
],
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
],
[
"Pioglit... | Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and... |
DB00703 | DB00959 | 997 | 1,486 | [
"DDInter1167",
"DDInter1191"
] | Methazolamide | Methylprednisolone | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
997,
24,
1486
]
],
[
[
997,
63,
175
],
[
175,
40,
1486
]
],
[
[
997,
24,
167
],
[
167,
1,
1486
]
],
[
[
997,
63,
251
],
[
251,
1... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone... | Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) rese... |
DB00277 | DB00448 | 1,031 | 1,215 | [
"DDInter1791",
"DDInter1022"
] | Theophylline | Lansoprazole | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Minor | 0 | [
[
[
1031,
23,
1215
]
],
[
[
1031,
24,
379
],
[
379,
1,
1215
]
],
[
[
1031,
63,
837
],
[
837,
1,
1215
]
],
[
[
1031,
6,
8374
],
[
8374,
... | [
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lansoprazole"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
],
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole (Compound) resembles Lansoprazole (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Pantoprazole and Pantoprazole (Compound) resembles Lansoprazo... |
DB01004 | DB11817 | 563 | 1,259 | [
"DDInter806",
"DDInter165"
] | Ganciclovir | Baricitinib | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Moderate | 1 | [
[
[
563,
24,
1259
]
],
[
[
563,
1,
248
],
[
248,
24,
1259
]
],
[
[
563,
24,
810
],
[
810,
24,
1259
]
],
[
[
563,
63,
254
],
[
254,
2... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baricitinib"
]
],
[
[
"Ganciclovir",
"{u} (Compound) resembles {v} (Compound)",
"Valganciclovir"
],
[
"Valganciclovir",
"{u} may caus... | Ganciclovir (Compound) resembles Valganciclovir (Compound) and Val
Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89 and Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Ganciclovir may... |
DB00834 | DB06616 | 932 | 594 | [
"DDInter1215",
"DDInter224"
] | Mifepristone | Bosutinib | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
932,
25,
594
]
],
[
[
932,
63,
883
],
[
883,
1,
594
]
],
[
[
932,
6,
8374
],
[
8374,
45,
594
]
],
[
[
932,
7,
2884
],
[
2884,
46... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"Gefitini... | Mifepristone may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Mifepristone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Mifepristone (Compound) upregulates ECH1 (Gene) and ECH1 (Gene) is... |
DB00470 | DB04948 | 530 | 1,084 | [
"DDInter601",
"DDInter1083"
] | Dronabinol | Lofexidine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
530,
24,
1084
]
],
[
[
530,
24,
1617
],
[
1617,
1,
1084
]
],
[
[
530,
24,
392
],
[
392,
24,
1084
]
],
[
[
530,
63,
701
],
[
701,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],
[... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Lofexidine (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that c... |
DB08899 | DB12245 | 129 | 823 | [
"DDInter649",
"DDInter1863"
] | Enzalutamide | Triclabendazole | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
129,
24,
823
]
],
[
[
129,
62,
1247
],
[
1247,
23,
823
]
],
[
[
129,
25,
1612
],
[
1612,
24,
823
]
],
[
[
129,
63,
1010
],
[
1010,
... | [
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Enzalutamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
... | Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Enzalutamide may lead to a major life threatening interaction when taken with Fostemsavir and Fos... |
DB00175 | DB00361 | 681 | 134 | [
"DDInter1509",
"DDInter1939"
] | Pravastatin | Vinorelbine | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction of third... | Moderate | 1 | [
[
[
681,
24,
134
]
],
[
[
681,
24,
147
],
[
147,
63,
134
]
],
[
[
681,
6,
4973
],
[
4973,
45,
134
]
],
[
[
681,
6,
8559
],
[
8559,
4... | [
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
]
],
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
],
... | Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine
Pravastatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Vinorelbine (Compound)
Pravastatin (C... |
DB01001 | DB01261 | 688 | 170 | [
"DDInter1632",
"DDInter1679"
] | Salbutamol | Sitagliptin | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
688,
24,
170
]
],
[
[
688,
6,
8374
],
[
8374,
45,
170
]
],
[
[
688,
21,
28850
],
[
28850,
60,
170
]
],
[
[
688,
24,
52
],
[
52,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Salbutamol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Salbutamol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sitagliptin (Compound)
Salbutamol (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Sitagliptin (Compound)
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and D... |
DB00467 | DB01050 | 1,467 | 848 | [
"DDInter644",
"DDInter900"
] | Enoxacin | Ibuprofen | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
1467,
24,
848
]
],
[
[
1467,
23,
1053
],
[
1053,
1,
848
]
],
[
[
1467,
23,
752
],
[
752,
23,
848
]
],
[
[
1467,
24,
286
],
[
286,
... | [
[
[
"Enoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Enoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Procarbazine"
],
[
"... | Enoxacin may cause a minor interaction that can limit clinical effects when taken with Procarbazine and Procarbazine (Compound) resembles Ibuprofen (Compound)
Enoxacin may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit cli... |
DB00215 | DB01259 | 1,230 | 392 | [
"DDInter388",
"DDInter1024"
] | Citalopram | Lapatinib | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Major | 2 | [
[
[
1230,
25,
392
]
],
[
[
1230,
6,
4973
],
[
4973,
45,
392
]
],
[
[
1230,
21,
29429
],
[
29429,
60,
392
]
],
[
[
1230,
23,
112
],
[
112,
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lapatinib"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Lapatinib"... | Citalopram (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Citalopram (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Lapatinib (Compound)
Citalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole... |
DB00331 | DB00909 | 1,645 | 306 | [
"DDInter1164",
"DDInter1971"
] | Metformin | Zonisamide | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Major | 2 | [
[
[
1645,
25,
306
]
],
[
[
1645,
18,
17480
],
[
17480,
57,
306
]
],
[
[
1645,
21,
28691
],
[
28691,
60,
306
]
],
[
[
1645,
24,
609
],
[
60... | [
[
[
"Metformin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zonisamide"
]
],
[
[
"Metformin",
"{u} (Compound) downregulates {v} (Gene)",
"ENOPH1"
],
[
"ENOPH1",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Metformin (Compound) downregulates ENOPH1 (Gene) and ENOPH1 (Gene) is downregulated by Zonisamide (Compound)
Metformin (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Zonisamide (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Clar... |
DB00468 | DB00757 | 1,424 | 1,166 | [
"DDInter1557",
"DDInter581"
] | Quinine | Dolasetron | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
1424,
25,
1166
]
],
[
[
1424,
6,
12523
],
[
12523,
45,
1166
]
],
[
[
1424,
21,
28726
],
[
28726,
60,
1166
]
],
[
[
1424,
23,
752
],
[
... | [
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Quinine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Dolasetron"
... | Quinine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dolasetron (Compound)
Quinine (Compound) causes Oliguria (Side Effect) and Oliguria (Side Effect) is caused by Dolasetron (Compound)
Quinine may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may ca... |
DB00261 | DB09020 | 702 | 28 | [
"DDInter93",
"DDInter212"
] | Anagrelide | Bisacodyl | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
702,
24,
28
]
],
[
[
702,
7,
2384
],
[
2384,
46,
28
]
],
[
[
702,
18,
4071
],
[
4071,
46,
28
]
],
[
[
702,
18,
10656
],
[
10656,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Anagrelide",
"{u} (Compound) upregulates {v} (Gene)",
"CDK6"
],
[
"CDK6",
"{u} (Gene) is upregulated by {v} (Comp... | Anagrelide (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Bisacodyl (Compound)
Anagrelide (Compound) downregulates PNP (Gene) and PNP (Gene) is upregulated by Bisacodyl (Compound)
Anagrelide (Compound) downregulates PSMG1 (Gene) and PSMG1 (Gene) is downregulated by Bisacodyl (Compound)
Anagrelide ... |
DB00420 | DB09020 | 508 | 28 | [
"DDInter1532",
"DDInter212"
] | Promazine | Bisacodyl | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
508,
24,
28
]
],
[
[
508,
24,
662
],
[
662,
1,
28
]
],
[
[
508,
63,
128
],
[
128,
40,
28
]
],
[
[
508,
35,
272
],
[
272,
40,
... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Promazine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Bisacodyl (Compound)
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine (Compound) resembles Bis... |
DB00261 | DB01050 | 702 | 848 | [
"DDInter93",
"DDInter900"
] | Anagrelide | Ibuprofen | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
702,
24,
848
]
],
[
[
702,
21,
28773
],
[
28773,
60,
848
]
],
[
[
702,
23,
297
],
[
297,
62,
848
]
],
[
[
702,
24,
62
],
[
62,
2... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Anagrelide",
"{u} (Compound) causes {v} (Side Effect)",
"Urethral disorder"
],
[
"Urethral disorder",
"{u} (Side ... | Anagrelide (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Ibuprofen (Compound)
Anagrelide may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Ibupro... |
DB00060 | DB08820 | 912 | 1,478 | [
"DDInter947",
"DDInter997"
] | Interferon beta-1a | Ivacaftor | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
912,
24,
1478
]
],
[
[
912,
24,
1398
],
[
1398,
63,
1478
]
],
[
[
912,
24,
866
],
[
866,
24,
1478
]
],
[
[
912,
63,
1560
],
[
1560,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macitentan"
... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Macitentan and Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Cobime... |
DB00365 | DB00694 | 839 | 51 | [
"DDInter842",
"DDInter485"
] | Grepafloxacin | Daunorubicin | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Major | 2 | [
[
[
839,
25,
51
]
],
[
[
839,
23,
112
],
[
112,
62,
51
]
],
[
[
839,
62,
134
],
[
134,
24,
51
]
],
[
[
839,
23,
1001
],
[
1001,
63,
... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Daunorubicin"
]
],
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"M... | Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Daunorubicin
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Vinorelbine a... |
DB01193 | DB08816 | 819 | 578 | [
"DDInter12",
"DDInter1802"
] | Acebutolol | Ticagrelor | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Minor | 0 | [
[
[
819,
23,
578
]
],
[
[
819,
6,
4973
],
[
4973,
45,
578
]
],
[
[
819,
21,
28646
],
[
28646,
60,
578
]
],
[
[
819,
40,
88
],
[
88,
... | [
[
[
"Acebutolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ticagrelor"
]
],
[
[
"Acebutolol",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Acebutolol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound)
Acebutolol (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Acebutolol (Compound) rese... |
DB00594 | DB01156 | 863 | 593 | [
"DDInter68",
"DDInter252"
] | Amiloride | Bupropion | A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Moderate | 1 | [
[
[
863,
24,
593
]
],
[
[
863,
21,
28757
],
[
28757,
60,
593
]
],
[
[
863,
62,
752
],
[
752,
23,
593
]
],
[
[
863,
24,
1383
],
[
1383,
... | [
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
]
],
[
[
"Amiloride",
"{u} (Compound) causes {v} (Side Effect)",
"Dyspepsia"
],
[
"Dyspepsia",
"{u} (Side Effect) is caused ... | Amiloride (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Bupropion (Compound)
Amiloride may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Bupropion
Amil... |
DB08880 | DB09276 | 1,510 | 381 | [
"DDInter1771",
"DDInter1682"
] | Teriflunomide | Sodium aurothiomalate | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Major | 2 | [
[
[
1510,
25,
381
]
],
[
[
1510,
64,
1683
],
[
1683,
24,
381
]
],
[
[
1510,
63,
597
],
[
597,
24,
381
]
],
[
[
1510,
25,
350
],
[
350,
... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ustekinumab"
],
[
"Ustekin... | Teriflunomide may lead to a major life threatening interaction when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol a... |
DB00213 | DB00808 | 837 | 1,605 | [
"DDInter1388",
"DDInter916"
] | Pantoprazole | Indapamide | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Moderate | 1 | [
[
[
837,
24,
1605
]
],
[
[
837,
24,
811
],
[
811,
1,
1605
]
],
[
[
837,
24,
1335
],
[
1335,
40,
1605
]
],
[
[
837,
6,
8374
],
[
8374,
... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
]
],
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
],
... | Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound)
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Indapamide (... |
DB12887 | DB12941 | 1,598 | 466 | [
"DDInter1750",
"DDInter481"
] | Tazemetostat | Darolutamide | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
1598,
24,
466
]
],
[
[
1598,
64,
600
],
[
600,
23,
466
]
],
[
[
1598,
63,
971
],
[
971,
23,
466
]
],
[
[
1598,
24,
159
],
[
159,
... | [
[
[
"Tazemetostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Tazemetostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
"Flu... | Tazemetostat may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Tazemetostat may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib ... |
DB00333 | DB11057 | 576 | 720 | [
"DDInter1166",
"DDInter1223"
] | Methadone | Mineral oil | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
576,
24,
720
]
],
[
[
576,
25,
927
],
[
927,
63,
720
]
],
[
[
576,
25,
1151
],
[
1151,
24,
720
]
],
[
[
576,
1,
675
],
[
675,
24... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encorafeni... | Methadone may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Methadone may lead to a major life threatening interaction when taken with Sunitinib and Sunitinib may cause a moderate inter... |
DB01168 | DB10316 | 1,053 | 334 | [
"DDInter1526",
"DDInter1248"
] | Procarbazine | Mumps virus strain B level jeryl lynn live antigen | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1053,
25,
334
]
],
[
[
1053,
64,
1057
],
[
1057,
25,
334
]
],
[
[
1053,
25,
908
],
[
908,
25,
334
]
],
[
[
1053,
63,
599
],
[
599,
... | [
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Procarbazine may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Procarbazine may lead to a major life threatening interaction when taken with Golimumab and Golimuma... |
DB01191 | DB06204 | 1,039 | 768 | [
"DDInter518",
"DDInter1746"
] | Dexfenfluramine | Tapentadol | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Major | 2 | [
[
[
1039,
25,
768
]
],
[
[
1039,
6,
10215
],
[
10215,
45,
768
]
],
[
[
1039,
63,
1347
],
[
1347,
24,
768
]
],
[
[
1039,
24,
1383
],
[
1383... | [
[
[
"Dexfenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tapentadol"
]
],
[
[
"Dexfenfluramine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
... | Dexfenfluramine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Tapentadol (Compound)
Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Tapentadol
Dexf... |
DB00635 | DB09322 | 1,573 | 1,114 | [
"DDInter1515",
"DDInter1966"
] | Prednisone | Zinc sulfate | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Minor | 0 | [
[
[
1573,
23,
1114
]
],
[
[
1573,
63,
66
],
[
66,
23,
1114
]
],
[
[
1573,
64,
1057
],
[
1057,
23,
1114
]
],
[
[
1573,
24,
259
],
[
259,
... | [
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"
],
[
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate
Prednisone may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause ... |
DB00853 | DB01206 | 1,686 | 37 | [
"DDInter1762",
"DDInter1086"
] | Temozolomide | Lomustine | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
1686,
24,
37
]
],
[
[
1686,
5,
11613
],
[
11613,
44,
37
]
],
[
[
1686,
6,
8374
],
[
8374,
45,
37
]
],
[
[
1686,
54,
19138
],
[
19138,
... | [
[
[
"Temozolomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Temozolomide",
"{u} (Compound) treats {v} (Disease)",
"brain cancer"
],
[
"brain cancer",
"{u} (Disease) is tre... | Temozolomide (Compound) treats brain cancer (Disease) and brain cancer (Disease) is treated by Lomustine (Compound)
Temozolomide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomustine (Compound)
Temozolomide (Compound) is included by Alkylating Activity (Pharmacologic Class) and Alkylating Activity (Pha... |
DB00938 | DB09082 | 455 | 659 | [
"DDInter1635",
"DDInter1934"
] | Salmeterol | Vilanterol | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
455,
24,
659
]
],
[
[
455,
23,
1220
],
[
1220,
23,
659
]
],
[
[
455,
62,
891
],
[
891,
23,
659
]
],
[
[
455,
63,
1570
],
[
1570,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Salmeterol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexamethasone"
],
[
... | Salmeterol may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Salmeterol may cause a minor interaction that can limit clinical effects when taken with Prednisolone and Pred... |
DB00376 | DB00986 | 1,105 | 1,192 | [
"DDInter1870",
"DDInter834"
] | Trihexyphenidyl | Glycopyrronium | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
1105,
35,
1192
]
],
[
[
1105,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
1105,
1,
1325
],
[
1325,
1,
1192
]
],
[
[
1105,
24,
262
],
[
262,
... | [
[
[
"Trihexyphenidyl",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate disease... | Trihexyphenidyl (Compound) resembles Glycopyrronium (Compound) and
Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Trihexyphenidyl (Compound) resembl... |
DB00358 | DB00502 | 1,010 | 1,300 | [
"DDInter1140",
"DDInter853"
] | Mefloquine | Haloperidol | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Major | 2 | [
[
[
1010,
25,
1300
]
],
[
[
1010,
25,
78
],
[
78,
1,
1300
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],
[
[
1010,
24,
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[
543,
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]
],
[
[
1010,
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[
8374,
... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Haloperidol"
]
],
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Droperidol"
],
[
"Droperidol",
"{u} ... | Mefloquine may lead to a major life threatening interaction when taken with Droperidol and Droperidol (Compound) resembles Haloperidol (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide may cause a moderate interaction that could exacerbate di... |
DB01222 | DB01259 | 617 | 392 | [
"DDInter246",
"DDInter1024"
] | Budesonide | Lapatinib | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
617,
24,
392
]
],
[
[
617,
6,
8374
],
[
8374,
45,
392
]
],
[
[
617,
7,
3727
],
[
3727,
46,
392
]
],
[
[
617,
7,
4675
],
[
4675,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Budesonide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Budesonide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Budesonide (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Lapatinib (Compound)
Budesonide (Compound) upregulates PLOD3 (Gene) and PLOD3 (Gene) is downregulated by Lapatinib (Compound)
Budesonide (Compound) d... |
DB00047 | DB01037 | 176 | 1,161 | [
"DDInter932",
"DDInter1653"
] | Insulin glargine | Selegiline | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual... | Moderate | 1 | [
[
[
176,
24,
1161
]
],
[
[
176,
24,
551
],
[
551,
1,
1161
]
],
[
[
176,
24,
280
],
[
280,
40,
1161
]
],
[
[
176,
24,
1411
],
[
1411,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selegiline"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Selegiline (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Mephentermine and Mephentermine (Compound) resembles Sele... |
DB00655 | DB01006 | 559 | 300 | [
"DDInter682",
"DDInter1040"
] | Estrone | Letrozole | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Moderate | 1 | [
[
[
559,
24,
300
]
],
[
[
559,
10,
11579
],
[
11579,
44,
300
]
],
[
[
559,
6,
8374
],
[
8374,
45,
300
]
],
[
[
559,
7,
2384
],
[
2384,
... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Letrozole"
]
],
[
[
"Estrone",
"{u} (Compound) palliates {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is treated ... | Estrone (Compound) palliates breast cancer (Disease) and breast cancer (Disease) is treated by Letrozole (Compound)
Estrone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Letrozole (Compound)
Estrone (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Letrozole (Compound)
Estrone (Compoun... |
DB00087 | DB00939 | 599 | 1,338 | [
"DDInter41",
"DDInter1135"
] | Alemtuzumab | Meclofenamic acid | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Moderate | 1 | [
[
[
599,
24,
1338
]
],
[
[
599,
24,
1479
],
[
1479,
63,
1338
]
],
[
[
599,
24,
1573
],
[
1573,
24,
1338
]
],
[
[
599,
63,
305
],
[
305,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic ac... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when tak... |
DB00254 | DB00703 | 964 | 997 | [
"DDInter598",
"DDInter1167"
] | Doxycycline | Methazolamide | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Minor | 0 | [
[
[
964,
23,
997
]
],
[
[
964,
23,
471
],
[
471,
1,
997
]
],
[
[
964,
6,
10612
],
[
10612,
45,
997
]
],
[
[
964,
1,
1572
],
[
1572,
... | [
[
[
"Doxycycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Methazolamide"
]
],
[
[
"Doxycycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetazolamide"
],
... | Doxycycline may cause a minor interaction that can limit clinical effects when taken with Acetazolamide and Acetazolamide (Compound) resembles Methazolamide (Compound)
Doxycycline (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Methazolamide (Compound)
Doxycycline (Compound) resembles Demeclocycline (Com... |
DB05239 | DB10343 | 866 | 962 | [
"DDInter425",
"DDInter160"
] | Cobimetinib | Bacillus calmette-guerin substrain tice live antigen | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
866,
25,
962
]
],
[
[
866,
64,
1057
],
[
1057,
25,
962
]
],
[
[
866,
63,
1213
],
[
1213,
25,
962
]
],
[
[
866,
24,
270
],
[
270,
... | [
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Cobimetinib may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Dasatin... |
DB01101 | DB04865 | 60 | 4 | [
"DDInter285",
"DDInter1335"
] | Capecitabine | Omacetaxine mepesuccinate | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
60,
24,
4
]
],
[
[
60,
6,
8569
],
[
8569,
57,
4
]
],
[
[
60,
64,
770
],
[
770,
24,
4
]
],
[
[
60,
24,
496
],
[
496,
63,
4
... | [
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Capecitabine",
"{u} (Compound) binds {v} (Gene)",
"TYMS"
],
[
"TYMS",
"{u} (Gene) is downregula... | Capecitabine (Compound) binds TYMS (Gene) and TYMS (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Capecitabine may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuc... |
DB00515 | DB11989 | 589 | 1,434 | [
"DDInter387",
"DDInter183"
] | Cisplatin | Benznidazole | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
589,
24,
1434
]
],
[
[
589,
24,
788
],
[
788,
24,
1434
]
],
[
[
589,
25,
375
],
[
375,
24,
1434
]
],
[
[
589,
24,
148
],
[
148,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
[
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Cisplatin may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizu... |
DB00867 | DB08881 | 1,052 | 868 | [
"DDInter1606",
"DDInter1925"
] | Ritodrine | Vemurafenib | Adrenergic beta-agonist used to control premature labor. | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
1052,
25,
868
]
],
[
[
1052,
7,
3422
],
[
3422,
46,
868
]
],
[
[
1052,
18,
2183
],
[
2183,
57,
868
]
],
[
[
1052,
35,
480
],
[
480,
... | [
[
[
"Ritodrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Ritodrine",
"{u} (Compound) upregulates {v} (Gene)",
"SATB1"
],
[
"SATB1",
"{u} (Gene) is upregulated by {v} (Compound)",
... | Ritodrine (Compound) upregulates SATB1 (Gene) and SATB1 (Gene) is upregulated by Vemurafenib (Compound)
Ritodrine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Vemurafenib (Compound)
Ritodrine (Compound) resembles Formoterol (Compound) and Ritodrine may cause a moderate interaction that cou... |
DB11718 | DB11730 | 927 | 351 | [
"DDInter640",
"DDInter1588"
] | Encorafenib | Ribociclib | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
927,
25,
351
]
],
[
[
927,
62,
1247
],
[
1247,
23,
351
]
],
[
[
927,
25,
283
],
[
283,
62,
351
]
],
[
[
927,
63,
479
],
[
479,
2... | [
[
[
"Encorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Encorafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulf... | Encorafenib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Encorafenib may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib ... |
DB01259 | DB09080 | 392 | 144 | [
"DDInter1024",
"DDInter1331"
] | Lapatinib | Olodaterol | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
392,
24,
144
]
],
[
[
392,
62,
1247
],
[
1247,
23,
144
]
],
[
[
392,
63,
956
],
[
956,
24,
144
]
],
[
[
392,
25,
1011
],
[
1011,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Lapatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Lapatinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Olodaterol
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and... |
DB01206 | DB10795 | 37 | 221 | [
"DDInter1086",
"DDInter1486"
] | Lomustine | Poliovirus type 1 antigen (formaldehyde inactivated) | An alkylating agent of value against both hematologic malignancies and solid tumors. | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
37,
24,
221
]
],
[
[
37,
64,
581
],
[
581,
24,
221
]
],
[
[
37,
63,
599
],
[
599,
24,
221
]
],
[
[
37,
24,
384
],
[
384,
24,
... | [
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Lomustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"In... | Lomustine may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Lomustine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB01021 | DB09020 | 674 | 28 | [
"DDInter1861",
"DDInter212"
] | Trichlormethiazide | Bisacodyl | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
674,
24,
28
]
],
[
[
674,
7,
4904
],
[
4904,
46,
28
]
],
[
[
674,
18,
9385
],
[
9385,
57,
28
]
],
[
[
674,
7,
8358
],
[
8358,
57... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Trichlormethiazide",
"{u} (Compound) upregulates {v} (Gene)",
"CNOT4"
],
[
"CNOT4",
"{u} (Gene) is upregu... | Trichlormethiazide (Compound) upregulates CNOT4 (Gene) and CNOT4 (Gene) is upregulated by Bisacodyl (Compound)
Trichlormethiazide (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Bisacodyl (Compound)
Trichlormethiazide (Compound) upregulates TSEN2 (Gene) and TSEN2 (Gene) is downregulated by ... |
DB09068 | DB12130 | 1,427 | 1,017 | [
"DDInter1948",
"DDInter1094"
] | Vortioxetine | Lorlatinib | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1427,
24,
1017
]
],
[
[
1427,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
1427,
63,
590
],
[
590,
24,
1017
]
],
[
[
1427,
24,
1421
],
[
1421... | [
[
[
"Vortioxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Vortioxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Vortioxetine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Vortioxetine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and A... |
DB01005 | DB01073 | 995 | 1,488 | [
"DDInter894",
"DDInter745"
] | Hydroxyurea | Fludarabine | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
995,
24,
1488
]
],
[
[
995,
63,
372
],
[
372,
1,
1488
]
],
[
[
995,
5,
11555
],
[
11555,
44,
1488
]
],
[
[
995,
6,
4362
],
[
4362,
... | [
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
... | Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Hydroxyurea (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Fludarabine (Compound)
Hydroxyurea (Compound) bind... |
DB04868 | DB06176 | 478 | 1,342 | [
"DDInter1293",
"DDInter1616"
] | Nilotinib | Romidepsin | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Major | 2 | [
[
[
478,
25,
1342
]
],
[
[
478,
62,
1247
],
[
1247,
23,
1342
]
],
[
[
478,
63,
336
],
[
336,
24,
1342
]
],
[
[
478,
64,
956
],
[
956,
... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Romidepsin"
]
],
[
[
"Nilotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfamet... | Nilotinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and ... |
DB00792 | DB00813 | 832 | 704 | [
"DDInter1878",
"DDInter722"
] | Tripelennamine | Fentanyl | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Moderate | 1 | [
[
[
832,
24,
704
]
],
[
[
832,
40,
11342
],
[
11342,
40,
704
]
],
[
[
832,
63,
194
],
[
194,
40,
704
]
],
[
[
832,
24,
543
],
[
543,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
]
],
[
[
"Tripelennamine",
"{u} (Compound) resembles {v} (Compound)",
"Aprindine"
],
[
"Aprindine",
"{u} (Compound) rese... | Tripelennamine (Compound) resembles Aprindine (Compound) and Aprindine (Compound) resembles Fentanyl (Compound)
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Darifenacin and Darifenacin (Compound) resembles Fentanyl (Compound)
Tripelennamine may cause a moderate interact... |
DB11901 | DB11952 | 913 | 800 | [
"DDInter107",
"DDInter612"
] | Apalutamide | Duvelisib | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements. It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resi... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Major | 2 | [
[
[
913,
25,
800
]
],
[
[
913,
25,
466
],
[
466,
62,
800
]
],
[
[
913,
63,
310
],
[
310,
24,
800
]
],
[
[
913,
25,
1476
],
[
1476,
6... | [
[
[
"Apalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Duvelisib"
]
],
[
[
"Apalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Darolutamide"
],
[
"Darolutamide",
"... | Apalutamide may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Duvelisib
Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may c... |
DB01259 | DB04575 | 392 | 35 | [
"DDInter1024",
"DDInter1555"
] | Lapatinib | Quinestrol | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | The 3-cyclopentyl ether of ethinyl estradiol. | Moderate | 1 | [
[
[
392,
24,
35
]
],
[
[
392,
63,
566
],
[
566,
1,
35
]
],
[
[
392,
24,
984
],
[
984,
40,
35
]
],
[
[
392,
63,
1336
],
[
1336,
40,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
]
],
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonorgestrel"
],
[
... | Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel and Levonorgestrel (Compound) resembles Quinestrol (Compound)
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol (Compound) resembles Quinestrol (Compound)
... |
DB00743 | DB09333 | 808 | 278 | [
"DDInter792",
"DDInter963"
] | Gadobenic acid | Iopodic acid | Gadobenic acid, usually available in the salt form gadobenate dimeglumine, is a linear MRI gadolinium-based contrast agent (GBCA) used primarily for MR imaging of the liver. It differs from other GBCAs due to the benzene ring that confers weak protein binding, thus leading to an increased R1 and R2 relaxivity. As gadob... | Iopodic acid, also known by the name of ipodate, is classified as a cholecystographic agent formed by a weak organic acid that contains a tri-iodinated benzene ring with iodine at positions 2, 4 and 6. Due to its particular structure, it presents a high degree of lipid solubility and a radiopaque property. It was devel... | Moderate | 1 | [
[
[
808,
24,
278
]
],
[
[
808,
63,
461
],
[
461,
24,
278
]
],
[
[
808,
24,
772
],
[
772,
24,
278
]
],
[
[
808,
40,
1431
],
[
1431,
2... | [
[
[
"Gadobenic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopodic acid"
]
],
[
[
"Gadobenic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
... | Gadobenic acid may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid
Gadobenic acid may cause a moderate interaction that could exacerbate diseases when taken with Carvedilol and Ca... |
DB00465 | DB01099 | 886 | 1,272 | [
"DDInter1010",
"DDInter744"
] | Ketorolac | Flucytosine | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | A fluorinated cytosine analog that is used as an antifungal agent. | Moderate | 1 | [
[
[
886,
24,
1272
]
],
[
[
886,
21,
29209
],
[
29209,
60,
1272
]
],
[
[
886,
24,
1448
],
[
1448,
24,
1272
]
],
[
[
886,
25,
1274
],
[
1274... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
]
],
[
[
"Ketorolac",
"{u} (Compound) causes {v} (Side Effect)",
"Anorexia"
],
[
"Anorexia",
"{u} (Side Effect) is caused ... | Ketorolac (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Flucytosine (Compound)
Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin and Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Flucyt... |
DB00444 | DB00570 | 63 | 147 | [
"DDInter1765",
"DDInter1936"
] | Teniposide | Vinblastine | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Minor | 0 | [
[
[
63,
23,
147
]
],
[
[
63,
63,
134
],
[
134,
24,
147
]
],
[
[
63,
5,
11555
],
[
11555,
44,
147
]
],
[
[
63,
6,
13695
],
[
13695,
4... | [
[
[
"Teniposide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vinblastine"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
],
[
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Teniposide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Vinb... |
DB00472 | DB00637 | 758 | 1,557 | [
"DDInter758",
"DDInter128"
] | Fluoxetine | Astemizole | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Major | 2 | [
[
[
758,
25,
1557
]
],
[
[
758,
6,
8374
],
[
8374,
45,
1557
]
],
[
[
758,
7,
8559
],
[
8559,
46,
1557
]
],
[
[
758,
18,
10375
],
[
10375,
... | [
[
[
"Fluoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Astemizole"
]
],
[
[
"Fluoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Astemiz... | Fluoxetine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Astemizole (Compound)
Fluoxetine (Compound) upregulates HMGCR (Gene) and HMGCR (Gene) is upregulated by Astemizole (Compound)
Fluoxetine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Astemizole (Compound)
Fluoxetine m... |
DB00317 | DB11901 | 883 | 913 | [
"DDInter810",
"DDInter107"
] | Gefitinib | Apalutamide | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
883,
24,
913
]
],
[
[
883,
24,
279
],
[
279,
24,
913
]
],
[
[
883,
63,
600
],
[
600,
24,
913
]
],
[
[
883,
24,
1320
],
[
1320,
6... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluc... |
DB00619 | DB01206 | 1,419 | 37 | [
"DDInter909",
"DDInter1086"
] | Imatinib | Lomustine | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
1419,
24,
37
]
],
[
[
1419,
5,
11555
],
[
11555,
44,
37
]
],
[
[
1419,
6,
8374
],
[
8374,
45,
37
]
],
[
[
1419,
21,
28722
],
[
28722,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Imatinib",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is... | Imatinib (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Lomustine (Compound)
Imatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomustine (Compound)
Imatinib (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lomustine (Compound... |
DB09065 | DB09292 | 760 | 1,202 | [
"DDInter424",
"DDInter1630"
] | Cobicistat | Sacubitril | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Sacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. It was approved by the FDA after being given the status of priority review for on July 7, 2015. Sacubitril'... | Moderate | 1 | [
[
[
760,
24,
1202
]
],
[
[
760,
64,
467
],
[
467,
24,
1202
]
],
[
[
760,
24,
1033
],
[
1033,
63,
1202
]
],
[
[
760,
63,
254
],
[
254,
... | [
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sacubitril"
]
],
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Simvastatin"
],
[
"Simvastat... | Cobicistat may lead to a major life threatening interaction when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Sacubitril
Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause ... |
DB00740 | DB09330 | 424 | 985 | [
"DDInter1596",
"DDInter1352"
] | Riluzole | Osimertinib | A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
424,
24,
985
]
],
[
[
424,
62,
1684
],
[
1684,
24,
985
]
],
[
[
424,
63,
663
],
[
663,
24,
985
]
],
[
[
424,
24,
1362
],
[
1362,
... | [
[
[
"Riluzole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Riluzole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Caffeine"
],
[
"Ca... | Riluzole may cause a minor interaction that can limit clinical effects when taken with Caffeine and Caffeine may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib
Riluzole may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate ... |
DB00059 | DB00759 | 1,560 | 1,620 | [
"DDInter1404",
"DDInter1783"
] | Pegaspargase | Tetracycline | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Moderate | 1 | [
[
[
1560,
24,
1620
]
],
[
[
1560,
24,
1572
],
[
1572,
40,
1620
]
],
[
[
1560,
24,
45
],
[
45,
62,
1620
]
],
[
[
1560,
24,
1254
],
[
1254,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracycline"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
]... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Tetracycline (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine may cause a minor interaction... |
DB00658 | DB01165 | 965 | 1,539 | [
"DDInter1663",
"DDInter1325"
] | Sevelamer | Ofloxacin | Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel. | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
965,
24,
1539
]
],
[
[
965,
63,
1467
],
[
1467,
1,
1539
]
],
[
[
965,
24,
945
],
[
945,
40,
1539
]
],
[
[
965,
24,
739
],
[
739,
... | [
[
[
"Sevelamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Sevelamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxacin"
],
[
"... | Sevelamer may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Sevelamer may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Seve... |
DB00215 | DB00975 | 1,230 | 1,317 | [
"DDInter388",
"DDInter573"
] | Citalopram | Dipyridamole | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Moderate | 1 | [
[
[
1230,
24,
1317
]
],
[
[
1230,
6,
4973
],
[
4973,
45,
1317
]
],
[
[
1230,
21,
28748
],
[
28748,
60,
1317
]
],
[
[
1230,
24,
714
],
[
71... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dipyridamole"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Citalopram (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dipyridamole (Compound)
Citalopram (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Dipyridamole (Compound)
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost... |
DB00683 | DB12267 | 1,382 | 1,476 | [
"DDInter1212",
"DDInter233"
] | Midazolam | Brigatinib | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
1382,
24,
1476
]
],
[
[
1382,
24,
629
],
[
629,
24,
1476
]
],
[
[
1382,
63,
1184
],
[
1184,
24,
1476
]
],
[
[
1382,
24,
982
],
[
982,
... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
],
[
... | Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra may... |
DB00471 | DB01118 | 201 | 33 | [
"DDInter1242",
"DDInter76"
] | Montelukast | Amiodarone | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
201,
24,
33
]
],
[
[
201,
6,
8717
],
[
8717,
45,
33
]
],
[
[
201,
7,
6952
],
[
6952,
46,
33
]
],
[
[
201,
21,
28681
],
[
28681,
... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Montelukast",
"{u} (Compound) binds {v} (Gene)",
"CYP2A6"
],
[
"CYP2A6",
"{u} (Gene) is bound by {v} (Compound)... | Montelukast (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Amiodarone (Compound)
Montelukast (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Amiodarone (Compound)
Montelukast (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Amiodaron... |
DB01246 | DB09118 | 820 | 1,580 | [
"DDInter45",
"DDInter1711"
] | Alimemazine | Stiripentol | A phenothiazine derivative that is used as an antipruritic. | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
820,
24,
1580
]
],
[
[
820,
63,
1532
],
[
1532,
24,
1580
]
],
[
[
820,
24,
1609
],
[
1609,
63,
1580
]
],
[
[
820,
25,
478
],
[
478,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine and ... |
DB01067 | DB06292 | 959 | 549 | [
"DDInter826",
"DDInter474"
] | Glipizide | Dapagliflozin | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
959,
24,
549
]
],
[
[
959,
24,
1344
],
[
1344,
40,
549
]
],
[
[
959,
6,
8374
],
[
8374,
45,
549
]
],
[
[
959,
21,
29222
],
[
29222,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Glipizide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Glipizide (Compound) causes Hypoglycaemia (Side Effect) ... |
DB09498 | DB15035 | 810 | 503 | [
"DDInter1715",
"DDInter1959"
] | Strontium chloride Sr-89 | Zanubrutinib | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Moderate | 1 | [
[
[
810,
24,
503
]
],
[
[
810,
63,
951
],
[
951,
24,
503
]
],
[
[
810,
24,
1619
],
[
1619,
24,
503
]
],
[
[
810,
63,
39
],
[
39,
25,... | [
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when ... |
DB00207 | DB11110 | 1,570 | 603 | [
"DDInter157",
"DDInter1115"
] | Azithromycin | Magnesium citrate | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1570,
24,
603
]
],
[
[
1570,
25,
57
],
[
57,
24,
603
]
],
[
[
1570,
24,
1616
],
[
1616,
24,
603
]
],
[
[
1570,
24,
484
],
[
484,
... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Azithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Azithromycin may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and... |
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