drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00222 | DB00963 | 245 | 1,263 | [
"DDInter825",
"DDInter241"
] | Glimepiride | Bromfenac | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Moderate | 1 | [
[
[
245,
24,
1263
]
],
[
[
245,
24,
935
],
[
935,
40,
1263
]
],
[
[
245,
24,
1512
],
[
1512,
24,
1263
]
],
[
[
245,
21,
28762
],
[
28762,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that coul... |
DB01017 | DB09473 | 1,669 | 884 | [
"DDInter1224",
"DDInter918"
] | Minocycline | Indium In-111 oxyquinoline | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detecte... | Moderate | 1 | [
[
[
1669,
24,
884
]
],
[
[
1669,
40,
1572
],
[
1572,
24,
884
]
],
[
[
1669,
1,
1545
],
[
1545,
24,
884
]
],
[
[
1669,
24,
319
],
[
319,
... | [
[
[
"Minocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indium In-111 oxyquinoline"
]
],
[
[
"Minocycline",
"{u} (Compound) resembles {v} (Compound)",
"Demeclocycline"
],
[
"Demeclocycline",
... | Minocycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Indium In-111 oxyquinoline
Minocycline (Compound) resembles Oxytetracycline (Compound) and Oxytetracycline may cause a moderate interaction that could exacerbate ... |
DB00046 | DB00999 | 1,179 | 504 | [
"DDInter940",
"DDInter883"
] | Insulin lispro | Hydrochlorothiazide | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Moderate | 1 | [
[
[
1179,
24,
504
]
],
[
[
1179,
24,
1326
],
[
1326,
40,
504
]
],
[
[
1179,
24,
178
],
[
178,
1,
504
]
],
[
[
1179,
24,
964
],
[
964,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenam... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Diclofenamide and Diclofenamide (Compound) resembles Hydrochlorothiazide (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resem... |
DB01238 | DB06603 | 673 | 39 | [
"DDInter118",
"DDInter1387"
] | Aripiprazole | Panobinostat | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
673,
24,
39
]
],
[
[
673,
62,
112
],
[
112,
23,
39
]
],
[
[
673,
63,
272
],
[
272,
24,
39
]
],
[
[
673,
24,
578
],
[
578,
63,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Aripiprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Aripiprazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniram... |
DB08889 | DB14730 | 350 | 1,412 | [
"DDInter299",
"DDInter264"
] | Carfilzomib | Calaspargase pegol | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
350,
24,
1412
]
],
[
[
350,
63,
1439
],
[
1439,
24,
1412
]
],
[
[
350,
64,
888
],
[
888,
24,
1412
]
],
[
[
350,
24,
713
],
[
713,
... | [
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
]... | Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab and Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Carfilzomib may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen ma... |
DB05578 | DB11718 | 330 | 927 | [
"DDInter1566",
"DDInter640"
] | Ramucirumab | Encorafenib | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
330,
25,
927
]
],
[
[
330,
64,
998
],
[
998,
24,
927
]
],
[
[
330,
63,
1100
],
[
1100,
24,
927
]
],
[
[
330,
25,
578
],
[
578,
2... | [
[
[
"Ramucirumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Ramucirumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenylbutazone"
],
[
"Phenylbutazone",
... | Ramucirumab may lead to a major life threatening interaction when taken with Phenylbutazone and Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Ramucirumab may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxi... |
DB06626 | DB09280 | 263 | 1,604 | [
"DDInter147",
"DDInter1101"
] | Axitinib | Lumacaftor | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Major | 2 | [
[
[
263,
25,
1604
]
],
[
[
263,
62,
379
],
[
379,
24,
1604
]
],
[
[
263,
63,
522
],
[
522,
24,
1604
]
],
[
[
263,
64,
307
],
[
307,
... | [
[
[
"Axitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
]
],
[
[
"Axitinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rabeprazole"
],
[
"Rabeprazole",
... | Axitinib may cause a minor interaction that can limit clinical effects when taken with Rabeprazole and Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirluka... |
DB06402 | DB09104 | 1,079 | 286 | [
"DDInter1756",
"DDInter1118"
] | Telavancin | Magnesium hydroxide | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1079,
24,
286
]
],
[
[
1079,
63,
820
],
[
820,
23,
286
]
],
[
[
1079,
63,
688
],
[
688,
24,
286
]
],
[
[
1079,
25,
1593
],
[
1593,
... | [
[
[
"Telavancin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Telavancin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]... | Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol a... |
DB01563 | DB01612 | 680 | 1,637 | [
"DDInter349",
"DDInter92"
] | Chloral hydrate | Amyl Nitrite | A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication. | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
680,
24,
1637
]
],
[
[
680,
64,
475
],
[
475,
24,
1637
]
],
[
[
680,
63,
401
],
[
401,
24,
1637
]
],
[
[
680,
24,
407
],
[
407,
... | [
[
[
"Chloral hydrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Chloral hydrate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Morphine"
],
[
"... | Chloral hydrate may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Chloral hydrate may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazin... |
DB05578 | DB06822 | 330 | 802 | [
"DDInter1566",
"DDInter1812"
] | Ramucirumab | Tinzaparin | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Major | 2 | [
[
[
330,
25,
802
]
],
[
[
330,
63,
222
],
[
222,
24,
802
]
],
[
[
330,
24,
1427
],
[
1427,
63,
802
]
],
[
[
330,
24,
643
],
[
643,
2... | [
[
[
"Ramucirumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
]
],
[
[
"Ramucirumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutra... | Ramucirumab may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Tinzaparin
Ramucirumab may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine and ... |
DB00938 | DB01165 | 455 | 1,539 | [
"DDInter1635",
"DDInter1325"
] | Salmeterol | Ofloxacin | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
455,
24,
1539
]
],
[
[
455,
63,
1176
],
[
1176,
1,
1539
]
],
[
[
455,
24,
945
],
[
945,
40,
1539
]
],
[
[
455,
24,
739
],
[
739,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Moxifloxacin"
],
[
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Comp... |
DB01096 | DB01362 | 678 | 497 | [
"DDInter1356",
"DDInter960"
] | Oxamniquine | Iohexol | An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Ex... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
678,
25,
497
]
],
[
[
678,
24,
1074
],
[
1074,
63,
497
]
],
[
[
678,
24,
1267
],
[
1267,
64,
497
]
],
[
[
678,
64,
534
],
[
534,
... | [
[
[
"Oxamniquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Oxamniquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
],
[
"Iodide I-... | Oxamniquine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123 and Iodide I-123 may cause a moderate interaction that could exacerbate diseases when taken with Iohexol
Oxamniquine may cause a moderate interaction that could exacerbate diseases when taken with Amifampridine and ... |
DB00488 | DB10276 | 196 | 1,624 | [
"DDInter57",
"DDInter1623"
] | Altretamine | Rotavirus vaccine | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
196,
25,
1624
]
],
[
[
196,
25,
770
],
[
770,
25,
1624
]
],
[
[
196,
63,
58
],
[
58,
25,
1624
]
],
[
[
196,
24,
869
],
[
869,
25... | [
[
[
"Altretamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Altretamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
],
[
"Thalidomide",
... | Altretamine may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may lead to a major life threatening interaction when taken with Rotavirus vaccine
Altretamine may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may lead to a ma... |
DB09291 | DB12015 | 741 | 1,033 | [
"DDInter1615",
"DDInter53"
] | Rolapitant | Alpelisib | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
741,
24,
1033
]
],
[
[
741,
62,
1135
],
[
1135,
23,
1033
]
],
[
[
741,
24,
738
],
[
738,
24,
1033
]
],
[
[
741,
63,
1510
],
[
1510,
... | [
[
[
"Rolapitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Rolapitant",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Rolapitant may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Alpelisib
Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may ... |
DB01058 | DB14575 | 978 | 733 | [
"DDInter1510",
"DDInter674"
] | Praziquantel | Eslicarbazepine | Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infecti... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
978,
24,
733
]
],
[
[
978,
63,
1101
],
[
1101,
23,
733
]
],
[
[
978,
24,
351
],
[
351,
24,
733
]
],
[
[
978,
25,
129
],
[
129,
2... | [
[
[
"Praziquantel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Praziquantel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],... | Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and... |
DB00041 | DB00384 | 1,648 | 1,275 | [
"DDInter38",
"DDInter1859"
] | Aldesleukin | Triamterene | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Moderate | 1 | [
[
[
1648,
24,
1275
]
],
[
[
1648,
24,
1527
],
[
1527,
63,
1275
]
],
[
[
1648,
24,
1061
],
[
1061,
24,
1275
]
],
[
[
1648,
25,
593
],
[
593... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamterene"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iothalamic acid"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid and Iothalamic acid may cause a moderate interaction that could exacerbate diseases when taken with Triamterene
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Treprost... |
DB00289 | DB09104 | 847 | 286 | [
"DDInter132",
"DDInter1118"
] | Atomoxetine | Magnesium hydroxide | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
847,
24,
286
]
],
[
[
847,
24,
820
],
[
820,
23,
286
]
],
[
[
847,
1,
109
],
[
109,
23,
286
]
],
[
[
847,
63,
1018
],
[
1018,
23... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
... | Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Atomoxetine (Compound) resembles Duloxetine (Compound) and Duloxetine may cause a minor interaction th... |
DB00283 | DB00792 | 701 | 832 | [
"DDInter395",
"DDInter1878"
] | Clemastine | Tripelennamine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
701,
24,
832
]
],
[
[
701,
24,
100
],
[
100,
63,
832
]
],
[
[
701,
24,
649
],
[
649,
1,
832
]
],
[
[
701,
35,
1594
],
[
1594,
24... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
],... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Clofeda... |
DB00197 | DB00682 | 1,324 | 126 | [
"DDInter1881",
"DDInter1951"
] | Troglitazone | Warfarin | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
1324,
24,
126
]
],
[
[
1324,
24,
1335
],
[
1335,
40,
126
]
],
[
[
1324,
24,
362
],
[
362,
24,
126
]
],
[
[
1324,
63,
168
],
[
168,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Warfarin (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin may cause a moderate interaction that... |
DB00556 | DB00738 | 1,262 | 485 | [
"DDInter1429",
"DDInter1420"
] | Perflutren | Pentamidine | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Moderate | 1 | [
[
[
1262,
24,
485
]
],
[
[
1262,
21,
28817
],
[
28817,
60,
485
]
],
[
[
1262,
23,
112
],
[
112,
62,
485
]
],
[
[
1262,
24,
971
],
[
971,
... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
]
],
[
[
"Perflutren",
"{u} (Compound) causes {v} (Side Effect)",
"Vision blurred"
],
[
"Vision blurred",
"{u} (Side Effe... | Perflutren (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Pentamidine (Compound)
Perflutren may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken... |
DB01234 | DB11827 | 1,220 | 433 | [
"DDInter513",
"DDInter669"
] | Dexamethasone | Ertugliflozin | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1220,
24,
433
]
],
[
[
1220,
40,
1103
],
[
1103,
23,
433
]
],
[
[
1220,
64,
646
],
[
646,
24,
433
]
],
[
[
1220,
63,
1020
],
[
1020,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Dexamethasone",
"{u} (Compound) resembles {v} (Compound)",
"Amcinonide"
],
[
"Amcinonide",
"{u} may cause ... | Dexamethasone (Compound) resembles Amcinonide (Compound) and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Ertugliflozin
Dexamethasone may lead to a major life threatening interaction when taken with Cinoxacin and Cinoxacin may cause a moderate interaction that could exacerbat... |
DB00201 | DB00857 | 1,684 | 1,387 | [
"DDInter263",
"DDInter1768"
] | Caffeine | Terbinafine | Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but ... | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Minor | 0 | [
[
[
1684,
23,
1387
]
],
[
[
1684,
6,
8374
],
[
8374,
45,
1387
]
],
[
[
1684,
18,
15501
],
[
15501,
57,
1387
]
],
[
[
1684,
21,
28734
],
[
... | [
[
[
"Caffeine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Terbinafine"
]
],
[
[
"Caffeine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Caffeine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Terbinafine (Compound)
Caffeine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Terbinafine (Compound)
Caffeine (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by ... |
DB08871 | DB12245 | 36 | 823 | [
"DDInter666",
"DDInter1863"
] | Eribulin | Triclabendazole | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
36,
24,
823
]
],
[
[
36,
62,
1247
],
[
1247,
23,
823
]
],
[
[
36,
63,
112
],
[
112,
23,
823
]
],
[
[
36,
24,
1612
],
[
1612,
24,... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Eribulin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Eribulin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazol... |
DB00501 | DB01263 | 752 | 859 | [
"DDInter380",
"DDInter1494"
] | Cimetidine | Posaconazole | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Moderate | 1 | [
[
[
752,
24,
859
]
],
[
[
752,
6,
4973
],
[
4973,
45,
859
]
],
[
[
752,
21,
28762
],
[
28762,
60,
859
]
],
[
[
752,
23,
112
],
[
112,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Posaconazole"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Cimetidine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound)
Cimetidine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Posaconazole (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Met... |
DB01319 | DB06203 | 34 | 1,002 | [
"DDInter777",
"DDInter51"
] | Fosamprenavir | Alogliptin | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
34,
24,
1002
]
],
[
[
34,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
34,
6,
8374
],
[
8374,
45,
1002
]
],
[
[
34,
21,
29340
],
[
29340,
... | [
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
... | Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Fosamprenavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Alogliptin (Compound)
Fosamprenavir (Compound) causes Stevens-Johnson syndrome (... |
DB00471 | DB00705 | 201 | 441 | [
"DDInter1242",
"DDInter496"
] | Montelukast | Delavirdine | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Moderate | 1 | [
[
[
201,
24,
441
]
],
[
[
201,
6,
8374
],
[
8374,
45,
441
]
],
[
[
201,
21,
29058
],
[
29058,
60,
441
]
],
[
[
201,
24,
1374
],
[
1374,
... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delavirdine"
]
],
[
[
"Montelukast",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Montelukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Delavirdine (Compound)
Montelukast (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Delavirdine (Compound)
Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone an... |
DB00570 | DB08873 | 147 | 74 | [
"DDInter1936",
"DDInter221"
] | Vinblastine | Boceprevir | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Major | 2 | [
[
[
147,
25,
74
]
],
[
[
147,
6,
4973
],
[
4973,
45,
74
]
],
[
[
147,
7,
2874
],
[
2874,
45,
74
]
],
[
[
147,
21,
28769
],
[
28769,
... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Boceprevir"
]
],
[
[
"Vinblastine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Bocepre... | Vinblastine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Boceprevir (Compound)
Vinblastine (Compound) upregulates CTSL (Gene) and CTSL (Gene) is bound by Boceprevir (Compound)
Vinblastine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Boceprevir (Compound)... |
DB00104 | DB09237 | 966 | 1,586 | [
"DDInter1323",
"DDInter1045"
] | Octreotide | Levamlodipine | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
966,
24,
1586
]
],
[
[
966,
23,
466
],
[
466,
62,
1586
]
],
[
[
966,
24,
549
],
[
549,
24,
1586
]
],
[
[
966,
25,
1101
],
[
1101,
... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Octreotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[... | Octreotide may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Levamlodipine
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and ... |
DB00196 | DB01181 | 600 | 1,532 | [
"DDInter743",
"DDInter906"
] | Fluconazole | Ifosfamide | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
600,
24,
1532
]
],
[
[
600,
6,
7524
],
[
7524,
45,
1532
]
],
[
[
600,
21,
29209
],
[
29209,
60,
1532
]
],
[
[
600,
23,
307
],
[
307,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)... | Fluconazole (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ifosfamide (Compound)
Fluconazole (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Ifosfamide (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafi... |
DB00209 | DB00782 | 352 | 1,123 | [
"DDInter1886",
"DDInter1535"
] | Trospium | Propantheline | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Moderate | 1 | [
[
[
352,
24,
1123
]
],
[
[
352,
6,
7992
],
[
7992,
45,
1123
]
],
[
[
352,
21,
28898
],
[
28898,
60,
1123
]
],
[
[
352,
23,
359
],
[
359,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
]
],
[
[
"Trospium",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound)",
... | Trospium (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Propantheline (Compound)
Trospium (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Propantheline (Compound)
Trospium may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide an... |
DB13074 | DB14006 | 877 | 972 | [
"DDInter1110",
"DDInter370"
] | Macimorelin | Choline salicylate | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
877,
24,
972
]
],
[
[
877,
63,
1573
],
[
1573,
24,
972
]
],
[
[
877,
63,
1573
],
[
1573,
23,
771
],
[
771,
62,
972
]
],
[
[
877,
... | [
[
[
"Macimorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Macimorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
]... | Macimorelin may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Macimorelin may cause a moderate interaction that could exacerbate diseases when taken with Prednisone ... |
DB03619 | DB06605 | 557 | 1,409 | [
"DDInter501",
"DDInter108"
] | Deoxycholic acid | Apixaban | Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
557,
24,
1409
]
],
[
[
557,
24,
1040
],
[
1040,
63,
1409
]
],
[
[
557,
24,
235
],
[
235,
64,
1409
]
],
[
[
557,
24,
1047
],
[
1047,
... | [
[
[
"Deoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Deoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]... | Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Apixaban
Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Desirudin a... |
DB00647 | DB01067 | 675 | 959 | [
"DDInter528",
"DDInter826"
] | Dextropropoxyphene | Glipizide | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
675,
24,
959
]
],
[
[
675,
63,
245
],
[
245,
40,
959
]
],
[
[
675,
24,
1411
],
[
1411,
1,
959
]
],
[
[
675,
6,
8374
],
[
8374,
4... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"... | Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Gli... |
DB00023 | DB00284 | 305 | 1,647 | [
"DDInter127",
"DDInter11"
] | Asparaginase Escherichia coli | Acarbose | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Moderate | 1 | [
[
[
305,
24,
1647
]
],
[
[
305,
24,
279
],
[
279,
62,
1647
]
],
[
[
305,
24,
1072
],
[
1072,
63,
1647
]
],
[
[
305,
24,
1176
],
[
1176,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione may cause a minor interaction that can limit clinical effects when taken with Acarbose
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases w... |
DB00992 | DB01128 | 842 | 918 | [
"DDInter1182",
"DDInter204"
] | Methyl aminolevulinate (topical) | Bicalutamide | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
842,
24,
918
]
],
[
[
842,
21,
29232
],
[
29232,
60,
918
]
],
[
[
842,
24,
1247
],
[
1247,
23,
918
]
],
[
[
842,
24,
392
],
[
392,
... | [
[
[
"Methyl aminolevulinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Methyl aminolevulinate",
"{u} (Compound) causes {v} (Side Effect)",
"Urticaria"
],
[
"Urticaria",
... | Methyl aminolevulinate may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide
Methyl aminolevulinate (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Bicalutamide (Compound)
Methyl aminolevulinate may cause a moderate interaction that could exacerb... |
DB00490 | DB09065 | 946 | 760 | [
"DDInter254",
"DDInter424"
] | Buspirone | Cobicistat | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
946,
24,
760
]
],
[
[
946,
63,
1101
],
[
1101,
23,
760
]
],
[
[
946,
24,
723
],
[
723,
24,
760
]
],
[
[
946,
25,
1264
],
[
1264,
... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant... |
DB00472 | DB00857 | 758 | 1,387 | [
"DDInter758",
"DDInter1768"
] | Fluoxetine | Terbinafine | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Moderate | 1 | [
[
[
758,
24,
1387
]
],
[
[
758,
6,
8374
],
[
8374,
45,
1387
]
],
[
[
758,
7,
3727
],
[
3727,
46,
1387
]
],
[
[
758,
18,
1848
],
[
1848,
... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terbinafine"
]
],
[
[
"Fluoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Fluoxetine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Terbinafine (Compound)
Fluoxetine (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Terbinafine (Compound)
Fluoxetine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is downregulated by Terbinafine (Compound)
Fluoxetine (Compo... |
DB01166 | DB14568 | 477 | 982 | [
"DDInter379",
"DDInter1000"
] | Cilostazol | Ivosidenib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
477,
25,
982
]
],
[
[
477,
62,
112
],
[
112,
23,
982
]
],
[
[
477,
63,
168
],
[
168,
23,
982
]
],
[
[
477,
63,
543
],
[
543,
24,... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Cilostazol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Cilostazol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bort... |
DB01254 | DB11110 | 1,213 | 603 | [
"DDInter484",
"DDInter1115"
] | Dasatinib | Magnesium citrate | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1213,
24,
603
]
],
[
[
1213,
64,
57
],
[
57,
24,
603
]
],
[
[
1213,
63,
789
],
[
789,
24,
603
]
],
[
[
1213,
24,
9
],
[
9,
24,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Dasatinib may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet and Fosca... |
DB06595 | DB09498 | 1,491 | 810 | [
"DDInter1214",
"DDInter1715"
] | Midostaurin | Strontium chloride Sr-89 | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
1491,
24,
810
]
],
[
[
1491,
63,
1555
],
[
1555,
24,
810
]
],
[
[
1491,
24,
310
],
[
310,
24,
810
]
],
[
[
1491,
24,
1619
],
[
1619,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Cab... |
DB00055 | DB15233 | 834 | 1,650 | [
"DDInter605",
"DDInter142"
] | Drotrecogin alfa | Avapritinib | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
834,
25,
1650
]
],
[
[
834,
24,
765
],
[
765,
24,
1650
]
],
[
[
834,
25,
1512
],
[
1512,
25,
1650
]
],
[
[
834,
64,
1578
],
[
1578,
... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Drotrecogin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hemin"
],
[
"He... | Drotrecogin alfa may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Drotrecogin alfa may lead to a major life threatening interaction when taken with Diclofenac and Diclofenac may lea... |
DB00346 | DB12500 | 472 | 283 | [
"DDInter44",
"DDInter714"
] | Alfuzosin | Fedratinib | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
472,
24,
283
]
],
[
[
472,
25,
351
],
[
351,
23,
283
]
],
[
[
472,
24,
1419
],
[
1419,
24,
283
]
],
[
[
472,
63,
600
],
[
600,
2... | [
[
[
"Alfuzosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Alfuzosin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Ribociclib",... | Alfuzosin may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Alfuzosin may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a modera... |
DB00218 | DB01261 | 1,176 | 170 | [
"DDInter1247",
"DDInter1679"
] | Moxifloxacin | Sitagliptin | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1176,
24,
170
]
],
[
[
1176,
21,
28850
],
[
28850,
60,
170
]
],
[
[
1176,
24,
52
],
[
52,
62,
170
]
],
[
[
1176,
25,
1616
],
[
1616,
... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Back pain"
],
[
"Back pain",
"{u} (Side Effect) is... | Moxifloxacin (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Sitagliptin (Compound)
Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when taken with Si... |
DB00704 | DB15762 | 267 | 725 | [
"DDInter1263",
"DDInter1644"
] | Naltrexone | Satralizumab | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare au... | Moderate | 1 | [
[
[
267,
24,
725
]
],
[
[
267,
24,
384
],
[
384,
24,
725
]
],
[
[
267,
63,
372
],
[
372,
24,
725
]
],
[
[
267,
63,
1066
],
[
1066,
2... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Satralizumab"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clo... |
DB00574 | DB01192 | 121 | 560 | [
"DDInter717",
"DDInter1372"
] | Fenfluramine | Oxymorphone | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
121,
24,
560
]
],
[
[
121,
63,
828
],
[
828,
1,
560
]
],
[
[
121,
24,
314
],
[
314,
1,
560
]
],
[
[
121,
64,
506
],
[
506,
24,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine (Compound) resembles Oxymorphone (Compou... |
DB00222 | DB00938 | 245 | 455 | [
"DDInter825",
"DDInter1635"
] | Glimepiride | Salmeterol | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
245,
24,
455
]
],
[
[
245,
24,
1523
],
[
1523,
25,
455
]
],
[
[
245,
24,
688
],
[
688,
63,
455
]
],
[
[
245,
21,
29024
],
[
29024,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol may lead to a major life threatening interaction when taken with Salmeterol
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause ... |
DB01218 | DB01224 | 1,493 | 623 | [
"DDInter852",
"DDInter1553"
] | Halofantrine | Quetiapine | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Major | 2 | [
[
[
1493,
25,
623
]
],
[
[
1493,
64,
827
],
[
827,
1,
623
]
],
[
[
1493,
63,
867
],
[
867,
1,
623
]
],
[
[
1493,
6,
12523
],
[
12523,
... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quetiapine"
]
],
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trazodone"
],
[
"Trazodone",
"{u}... | Halofantrine may lead to a major life threatening interaction when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Halofantrine may cause a moderate interaction that could exacerbate diseases when taken with Olanzapine and Olanzapine (Compound) resembles Quetiapine (Compound)
Halofantrine ... |
DB01246 | DB01377 | 820 | 1,283 | [
"DDInter45",
"DDInter1119"
] | Alimemazine | Magnesium oxide | A phenothiazine derivative that is used as an antipruritic. | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
820,
23,
1283
]
],
[
[
820,
63,
743
],
[
743,
23,
1283
]
],
[
[
820,
75,
684
],
[
684,
23,
1283
]
],
[
[
820,
74,
216
],
[
216,
... | [
[
[
"Alimemazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
],
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Alimemazine (Compound) resembles Thioridazine (Compound) and Alimemazine may lead to a major life threatenin... |
DB00675 | DB01041 | 888 | 770 | [
"DDInter1744",
"DDInter1789"
] | Tamoxifen | Thalidomide | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
888,
25,
770
]
],
[
[
888,
64,
1668
],
[
1668,
1,
770
]
],
[
[
888,
6,
6365
],
[
6365,
45,
770
]
],
[
[
888,
7,
7669
],
[
7669,
... | [
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenalidomide"
],
[
"Lenalidomide",
"{u... | Tamoxifen may lead to a major life threatening interaction when taken with Lenalidomide and Lenalidomide (Compound) resembles Thalidomide (Compound)
Tamoxifen (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Thalidomide (Compound)
Tamoxifen (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated... |
DB08820 | DB14575 | 1,478 | 733 | [
"DDInter997",
"DDInter674"
] | Ivacaftor | Eslicarbazepine | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
1478,
24,
733
]
],
[
[
1478,
63,
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],
[
1101,
23,
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],
[
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63,
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],
[
1491,
24,
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],
[
[
1478,
23,
1135
],
[
1135,... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[... | Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Mido... |
DB01064 | DB01169 | 1,148 | 57 | [
"DDInter987",
"DDInter120"
] | Isoprenaline | Arsenic trioxide | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
1148,
25,
57
]
],
[
[
1148,
6,
2686
],
[
2686,
45,
57
]
],
[
[
1148,
63,
480
],
[
480,
24,
57
]
],
[
[
1148,
24,
144
],
[
144,
6... | [
[
[
"Isoprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Isoprenaline",
"{u} (Compound) binds {v} (Gene)",
"MAPK1"
],
[
"MAPK1",
"{u} (Gene) is bound by {v} (Compound)",
... | Isoprenaline (Compound) binds MAPK1 (Gene) and MAPK1 (Gene) is bound by Arsenic trioxide (Compound)
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide
Isop... |
DB05676 | DB12825 | 1,513 | 1,375 | [
"DDInter111",
"DDInter1032"
] | Apremilast | Lefamulin | Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
1513,
24,
1375
]
],
[
[
1513,
63,
1101
],
[
1101,
24,
1375
]
],
[
[
1513,
24,
98
],
[
98,
24,
1375
]
],
[
[
1513,
25,
913
],
[
913,
... | [
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem ... |
DB01115 | DB12332 | 336 | 1,619 | [
"DDInter1291",
"DDInter1626"
] | Nifedipine | Rucaparib | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
336,
24,
1619
]
],
[
[
336,
23,
1135
],
[
1135,
23,
1619
]
],
[
[
336,
24,
259
],
[
259,
24,
1619
]
],
[
[
336,
40,
84
],
[
84,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Nifedipine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Nifedipine may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept ma... |
DB00013 | DB00686 | 1,255 | 383 | [
"DDInter1905",
"DDInter1424"
] | Urokinase | Pentosan polysulfate | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | Moderate | 1 | [
[
[
1255,
24,
383
]
],
[
[
1255,
24,
714
],
[
714,
63,
383
]
],
[
[
1255,
25,
405
],
[
405,
63,
383
]
],
[
[
1255,
24,
1061
],
[
1061,
... | [
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
]
],
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
],
... | Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate
Urokinase may lead to a major life threatening interaction when taken with Acalabrutinib and Acalabrutinib ... |
DB00850 | DB11978 | 1,630 | 124 | [
"DDInter1432",
"DDInter822"
] | Perphenazine | Glasdegib | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1630,
24,
124
]
],
[
[
1630,
23,
112
],
[
112,
23,
124
]
],
[
[
1630,
64,
475
],
[
475,
24,
124
]
],
[
[
1630,
63,
79
],
[
79,
2... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Perphenazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Perphenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Perphenazine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause... |
DB08931 | DB09104 | 947 | 286 | [
"DDInter1600",
"DDInter1118"
] | Riociguat | Magnesium hydroxide | Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurre... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
947,
24,
286
]
],
[
[
947,
63,
1593
],
[
1593,
24,
286
]
],
[
[
947,
24,
982
],
[
982,
63,
286
]
],
[
[
947,
63,
1593
],
[
1593,
... | [
[
[
"Riociguat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Riociguat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
... | Riociguat may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide
Riociguat may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib and... |
DB00731 | DB01138 | 1,144 | 804 | [
"DDInter1269",
"DDInter1726"
] | Nateglinide | Sulfinpyrazone | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Minor | 0 | [
[
[
1144,
23,
804
]
],
[
[
1144,
24,
998
],
[
998,
1,
804
]
],
[
[
1144,
6,
9320
],
[
9320,
45,
804
]
],
[
[
1144,
63,
168
],
[
168,
... | [
[
[
"Nateglinide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfinpyrazone"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
],
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Sulfinpyrazone (Compound)
Nateglinide (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) is bound by Sulfinpyrazone (Compound)
Nateglinide may cause a moderate interaction that ... |
DB08901 | DB09030 | 1,468 | 840 | [
"DDInter1492",
"DDInter1945"
] | Ponatinib | Vorapaxar | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
1468,
25,
840
]
],
[
[
1468,
63,
765
],
[
765,
24,
840
]
],
[
[
1468,
64,
885
],
[
885,
24,
840
]
],
[
[
1468,
24,
1017
],
[
1017,
... | [
[
[
"Ponatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hemin"
],
[
"Hemin",
"{u}... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Ponatinib may lead to a major life threatening interaction when taken with Epoprostenol and Epoprostenol may cause a moderat... |
DB00529 | DB08875 | 789 | 1,618 | [
"DDInter779",
"DDInter262"
] | Foscarnet | Cabozantinib | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
789,
25,
1618
]
],
[
[
789,
23,
112
],
[
112,
23,
1618
]
],
[
[
789,
24,
1662
],
[
1662,
63,
1618
]
],
[
[
789,
24,
480
],
[
480,
... | [
[
[
"Foscarnet",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Foscarnet",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Foscarnet may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid a... |
DB00261 | DB09104 | 702 | 286 | [
"DDInter93",
"DDInter1118"
] | Anagrelide | Magnesium hydroxide | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
702,
24,
286
]
],
[
[
702,
25,
820
],
[
820,
23,
286
]
],
[
[
702,
24,
1119
],
[
1119,
23,
286
]
],
[
[
702,
63,
1018
],
[
1018,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
],
[
"... | Anagrelide may lead to a major life threatening interaction when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepoxide and Chlord... |
DB00978 | DB01073 | 739 | 1,488 | [
"DDInter1084",
"DDInter745"
] | Lomefloxacin | Fludarabine | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Minor | 0 | [
[
[
739,
23,
1488
]
],
[
[
739,
62,
372
],
[
372,
1,
1488
]
],
[
[
739,
21,
28701
],
[
28701,
60,
1488
]
],
[
[
739,
1,
1539
],
[
1539,
... | [
[
[
"Lomefloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fludarabine"
]
],
[
[
"Lomefloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clofarabine"
],
[
... | Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Lomefloxacin (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Fludarabine (Compound)
Lomefloxacin (Compound) resembles Of... |
DB00959 | DB11071 | 1,486 | 1,004 | [
"DDInter1191",
"DDInter1449"
] | Methylprednisolone | Phenyl salicylate | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
1486,
24,
1004
]
],
[
[
1486,
23,
771
],
[
771,
62,
1004
]
],
[
[
1486,
24,
1411
],
[
1411,
24,
1004
]
],
[
[
1486,
40,
1573
],
[
1573... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Methylprednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyalur... | Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Phenyl salicylate
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken w... |
DB08904 | DB12834 | 375 | 148 | [
"DDInter342",
"DDInter1649"
] | Certolizumab pegol | Secnidazole | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
375,
24,
148
]
],
[
[
375,
63,
1593
],
[
1593,
24,
148
]
],
[
[
375,
25,
1480
],
[
1480,
24,
148
]
],
[
[
375,
24,
1434
],
[
1434,
... | [
[
[
"Certolizumab pegol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Certolizumab pegol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib... | Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Certolizumab pegol may lead to a major life threatening interaction when taken with Ixazomib and Ixazom... |
DB00023 | DB04855 | 305 | 540 | [
"DDInter127",
"DDInter602"
] | Asparaginase Escherichia coli | Dronedarone | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Moderate | 1 | [
[
[
305,
24,
540
]
],
[
[
305,
24,
33
],
[
33,
40,
540
]
],
[
[
305,
24,
473
],
[
473,
24,
540
]
],
[
[
305,
24,
187
],
[
187,
63,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone (Compound) resembles Dronedarone (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide ma... |
DB00758 | DB14357 | 1,347 | 944 | [
"DDInter413",
"DDInter347"
] | Clopidogrel | Chamomile | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
1347,
23,
944
]
],
[
[
1347,
36,
256
],
[
256,
23,
944
]
],
[
[
1347,
63,
582
],
[
582,
23,
944
]
],
[
[
1347,
64,
366
],
[
366,
... | [
[
[
"Clopidogrel",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Clopidogrel",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",
... | Clopidogrel (Compound) resembles Prasugrel (Compound) and Clopidogrel may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Clopidogrel may cause a moderate interaction that could exacerbate diseas... |
DB00106 | DB00834 | 618 | 932 | [
"DDInter4",
"DDInter1215"
] | Abarelix | Mifepristone | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Major | 2 | [
[
[
618,
25,
932
]
],
[
[
618,
23,
112
],
[
112,
62,
932
]
],
[
[
618,
24,
480
],
[
480,
63,
932
]
],
[
[
618,
24,
355
],
[
355,
24,... | [
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mifepristone"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazo... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Mifepristone
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formot... |
DB00283 | DB01224 | 701 | 623 | [
"DDInter395",
"DDInter1553"
] | Clemastine | Quetiapine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
701,
24,
623
]
],
[
[
701,
24,
827
],
[
827,
1,
623
]
],
[
[
701,
35,
252
],
[
252,
1,
623
]
],
[
[
701,
6,
12523
],
[
12523,
45... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Clemastine (Compound) resembles Hydroxyzine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine ... |
DB01225 | DB01381 | 500 | 958 | [
"DDInter645",
"DDInter819"
] | Enoxaparin | Ginkgo biloba | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
500,
24,
958
]
],
[
[
500,
64,
1347
],
[
1347,
24,
958
]
],
[
[
500,
63,
121
],
[
121,
24,
958
]
],
[
[
500,
25,
792
],
[
792,
6... | [
[
[
"Enoxaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Enoxaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clopidogrel"
],
[
"Clopid... | Enoxaparin may lead to a major life threatening interaction when taken with Clopidogrel and Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine m... |
DB04911 | DB11703 | 968 | 405 | [
"DDInter1347",
"DDInter9"
] | Oritavancin | Acalabrutinib | Oritavancin is a glycopeptide antibiotic used for the treatment of skin infections. It was developed by The Medicines Company (acquired by Novartis). Oritavancin was initially approved by the FDA in 2014 and formulated to combat susceptible gram-positive bacteria that cause skin and skin structure infections. It boasts... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
968,
24,
405
]
],
[
[
968,
24,
1297
],
[
1297,
63,
405
]
],
[
[
968,
24,
868
],
[
868,
24,
405
]
],
[
[
968,
63,
126
],
[
126,
2... | [
[
[
"Oritavancin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Oritavancin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
],
... | Oritavancin may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and Osilodrostat may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Oritavancin may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib ... |
DB01101 | DB06372 | 60 | 259 | [
"DDInter285",
"DDInter1594"
] | Capecitabine | Rilonacept | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
60,
24,
259
]
],
[
[
60,
63,
1461
],
[
1461,
23,
259
]
],
[
[
60,
24,
37
],
[
37,
24,
259
]
],
[
[
60,
24,
1330
],
[
1330,
63,
... | [
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[... | Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomusti... |
DB00104 | DB00247 | 966 | 1,131 | [
"DDInter1323",
"DDInter1194"
] | Octreotide | Methysergide | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize sero... | Moderate | 1 | [
[
[
966,
24,
1131
]
],
[
[
966,
24,
469
],
[
469,
40,
1131
]
],
[
[
966,
24,
628
],
[
628,
1,
1131
]
],
[
[
966,
21,
28701
],
[
28701,
... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methysergide"
]
],
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromocriptine"
],
... | Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Bromocriptine and Bromocriptine (Compound) resembles Methysergide (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Ergometrine and Ergometrine (Compound) resembles Methysergide... |
DB00434 | DB00843 | 13 | 479 | [
"DDInter459",
"DDInter583"
] | Cyproheptadine | Donepezil | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
13,
24,
479
]
],
[
[
13,
24,
843
],
[
843,
1,
479
]
],
[
[
13,
6,
4228
],
[
4228,
45,
479
]
],
[
[
13,
7,
2900
],
[
2900,
46,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine and Tetrabenazine (Compound) resembles Donepezil (Compound)
Cyproheptadine (Compound) binds HTR2A (Gene) and HTR2A (Gene) is bound by Donepezil (Compound)
Cyproheptadine (Compound) upregulates NFKBIA (Gene) and ... |
DB00691 | DB08880 | 1,058 | 1,510 | [
"DDInter1237",
"DDInter1771"
] | Moexipril | Teriflunomide | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1058,
25,
1510
]
],
[
[
1058,
24,
1144
],
[
1144,
24,
1510
]
],
[
[
1058,
24,
1450
],
[
1450,
63,
1510
]
],
[
[
1058,
63,
1061
],
[
10... | [
[
[
"Moexipril",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
[
"Nateglin... | Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and ... |
DB00361 | DB01610 | 134 | 248 | [
"DDInter1939",
"DDInter1912"
] | Vinorelbine | Valganciclovir | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Moderate | 1 | [
[
[
134,
24,
248
]
],
[
[
134,
24,
563
],
[
563,
1,
248
]
],
[
[
134,
21,
29209
],
[
29209,
60,
248
]
],
[
[
134,
63,
1101
],
[
1101,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
],
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Vinorelbine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Valganciclovir (Compound)
Vinorelbine may cause a moderate i... |
DB01105 | DB12825 | 222 | 1,375 | [
"DDInter1665",
"DDInter1032"
] | Sibutramine | Lefamulin | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
222,
24,
1375
]
],
[
[
222,
23,
159
],
[
159,
63,
1375
]
],
[
[
222,
63,
530
],
[
530,
24,
1375
]
],
[
[
222,
24,
659
],
[
659,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Sibutramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Larotrectinib"
],
[
... | Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and D... |
DB01024 | DB01413 | 1,096 | 1,403 | [
"DDInter1252",
"DDInter317"
] | Mycophenolic acid | Cefepime | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Cefepime is a fourth-generation cephalosporin antibiotic developed in 1994. Cefepime is active against Gram-positive and Gram-negative bacteria, and has greater activity against both compared to third-generation antibiotics.[A2457,A249050] Cefepime is normally used to treat severe nosocomial pneumonia and infections ca... | Moderate | 1 | [
[
[
1096,
24,
1403
]
],
[
[
1096,
24,
1462
],
[
1462,
1,
1403
]
],
[
[
1096,
24,
1024
],
[
1024,
40,
1403
]
],
[
[
1096,
63,
1087
],
[
108... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefepime"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefditoren"
... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Cefditoren and Cefditoren (Compound) resembles Cefepime (Compound)
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Cefpodoxime and Cefpodoxime (Compound) resembles Cefepime... |
DB00574 | DB09038 | 121 | 1,450 | [
"DDInter717",
"DDInter636"
] | Fenfluramine | Empagliflozin | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
121,
24,
1450
]
],
[
[
121,
24,
659
],
[
659,
63,
1450
]
],
[
[
121,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
121,
24,
885
],
[
885,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
],
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil a... |
DB00213 | DB01076 | 837 | 700 | [
"DDInter1388",
"DDInter133"
] | Pantoprazole | Atorvastatin | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Moderate | 1 | [
[
[
837,
24,
700
]
],
[
[
837,
6,
4973
],
[
4973,
45,
700
]
],
[
[
837,
24,
126
],
[
126,
23,
700
]
],
[
[
837,
24,
467
],
[
467,
24... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atorvastatin"
]
],
[
[
"Pantoprazole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compoun... | Pantoprazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Atorvastatin (Compound)
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Atorvastatin
Pantoprazole may c... |
DB00414 | DB00612 | 590 | 1,121 | [
"DDInter16",
"DDInter216"
] | Acetohexamide | Bisoprolol | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Moderate | 1 | [
[
[
590,
24,
1121
]
],
[
[
590,
24,
819
],
[
819,
40,
1121
]
],
[
[
590,
63,
88
],
[
88,
40,
1121
]
],
[
[
590,
63,
417
],
[
417,
23... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisoprolol"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Bisoprolol (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Bisoprolol (Comp... |
DB00205 | DB00563 | 929 | 663 | [
"DDInter1550",
"DDInter1174"
] | Pyrimethamine | Methotrexate | One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
929,
24,
663
]
],
[
[
929,
6,
2946
],
[
2946,
45,
663
]
],
[
[
929,
7,
4596
],
[
4596,
46,
663
]
],
[
[
929,
18,
1917
],
[
1917,
... | [
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Pyrimethamine",
"{u} (Compound) binds {v} (Gene)",
"DHFR"
],
[
"DHFR",
"{u} (Gene) is bound by {v} (Compoun... | Pyrimethamine (Compound) binds DHFR (Gene) and DHFR (Gene) is bound by Methotrexate (Compound)
Pyrimethamine (Compound) upregulates PTPN6 (Gene) and PTPN6 (Gene) is upregulated by Methotrexate (Compound)
Pyrimethamine (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Methotrexate (Compound)
P... |
DB06616 | DB11730 | 594 | 351 | [
"DDInter224",
"DDInter1588"
] | Bosutinib | Ribociclib | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
594,
25,
351
]
],
[
[
594,
62,
1247
],
[
1247,
23,
351
]
],
[
[
594,
25,
283
],
[
283,
62,
351
]
],
[
[
594,
24,
1627
],
[
1627,
... | [
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Bosutinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfamet... | Bosutinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Bosutinib may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may ... |
DB01131 | DB09121 | 1,243 | 1,328 | [
"DDInter1531",
"DDInter140"
] | Proguanil | Aurothioglucose | Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, _Plasmodium falciparum_ and _Plasmodium vivax_, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite. | Aurothioglucose, also known as gold thioglucose, was formerly used to treat rheumatoid arthritis. Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis . The use of gold compounds has decreased si... | Major | 2 | [
[
[
1243,
25,
1328
]
],
[
[
1243,
63,
929
],
[
929,
25,
1328
]
],
[
[
1243,
63,
126
],
[
126,
63,
367
],
[
367,
24,
1328
]
],
[
[
1243,
... | [
[
[
"Proguanil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aurothioglucose"
]
],
[
[
"Proguanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pyrimethamine"
],
[
"Pyri... | Proguanil may cause a moderate interaction that could exacerbate diseases when taken with Pyrimethamine and Pyrimethamine may lead to a major life threatening interaction when taken with Aurothioglucose
Proguanil may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may c... |
DB00205 | DB01131 | 929 | 1,243 | [
"DDInter1550",
"DDInter1531"
] | Pyrimethamine | Proguanil | One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, _Plasmodium falciparum_ and _Plasmodium vivax_, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite. | Moderate | 1 | [
[
[
929,
24,
1243
]
],
[
[
929,
5,
11571
],
[
11571,
44,
1243
]
],
[
[
929,
6,
2946
],
[
2946,
45,
1243
]
],
[
[
929,
54,
19176
],
[
19176... | [
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Proguanil"
]
],
[
[
"Pyrimethamine",
"{u} (Compound) treats {v} (Disease)",
"malaria"
],
[
"malaria",
"{u} (Disease) is treated by ... | Pyrimethamine (Compound) treats malaria (Disease) and malaria (Disease) is treated by Proguanil (Compound)
Pyrimethamine (Compound) binds DHFR (Gene) and DHFR (Gene) is bound by Proguanil (Compound)
Pyrimethamine (Compound) is included by Dihydrofolate Reductase Inhibitors (Pharmacologic Class) and Dihydrofolate Reduct... |
DB05294 | DB08870 | 1,069 | 850 | [
"DDInter1917",
"DDInter228"
] | Vandetanib | Brentuximab vedotin | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1069,
24,
850
]
],
[
[
1069,
64,
1570
],
[
1570,
24,
850
]
],
[
[
1069,
1,
883
],
[
883,
24,
850
]
],
[
[
1069,
24,
159
],
[
159,
... | [
[
[
"Vandetanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azithromycin"
],
[
... | Vandetanib may lead to a major life threatening interaction when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Vandetanib (Compound) resembles Gefitinib (Compound) and Gefitinib may cause a moderate interaction that could exa... |
DB00798 | DB01112 | 1,132 | 665 | [
"DDInter815",
"DDInter335"
] | Gentamicin | Cefuroxime | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus. | Moderate | 1 | [
[
[
1132,
24,
665
]
],
[
[
1132,
24,
1323
],
[
1323,
1,
665
]
],
[
[
1132,
63,
149
],
[
149,
40,
665
]
],
[
[
1132,
63,
1087
],
[
1087,
... | [
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefuroxime"
]
],
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefonicid"
],
[
... | Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Cefonicid and Cefonicid (Compound) resembles Cefuroxime (Compound)
Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime and Ceftazidime (Compound) resembles Cefuroxime (Compound)
... |
DB08815 | DB11827 | 154 | 433 | [
"DDInter1104",
"DDInter669"
] | Lurasidone | Ertugliflozin | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
154,
24,
433
]
],
[
[
154,
63,
959
],
[
959,
24,
433
]
],
[
[
154,
64,
609
],
[
609,
24,
433
]
],
[
[
154,
24,
1033
],
[
1033,
6... | [
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Lurasidone may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin m... |
DB00674 | DB09098 | 1,516 | 98 | [
"DDInter802",
"DDInter1700"
] | Galantamine | Somatrem | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1516,
24,
98
]
],
[
[
1516,
63,
11
],
[
11,
24,
98
]
],
[
[
1516,
24,
609
],
[
609,
24,
98
]
],
[
[
1516,
24,
124
],
[
124,
63,
... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Toremifene"
],
[
... | Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Cl... |
DB00095 | DB11714 | 66 | 1,316 | [
"DDInter623",
"DDInter610"
] | Efalizumab | Durvalumab | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote... | Moderate | 1 | [
[
[
66,
24,
1316
]
],
[
[
66,
23,
1461
],
[
1461,
23,
1316
]
],
[
[
66,
24,
167
],
[
167,
24,
1316
]
],
[
[
66,
24,
270
],
[
270,
63... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Durvalumab"
]
],
[
[
"Efalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Efalizumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Durvalumab
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocor... |
DB00202 | DB00512 | 190 | 91 | [
"DDInter1716",
"DDInter1916"
] | Succinylcholine | Vancomycin | Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and su... | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Moderate | 1 | [
[
[
190,
24,
91
]
],
[
[
190,
21,
29118
],
[
29118,
60,
91
]
],
[
[
190,
25,
1481
],
[
1481,
63,
91
]
],
[
[
190,
24,
1287
],
[
1287,
... | [
[
[
"Succinylcholine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vancomycin"
]
],
[
[
"Succinylcholine",
"{u} (Compound) causes {v} (Side Effect)",
"Tachycardia"
],
[
"Tachycardia",
"{u} (Side E... | Succinylcholine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Vancomycin (Compound)
Succinylcholine may lead to a major life threatening interaction when taken with Polymyxin B and Polymyxin B may cause a moderate interaction that could exacerbate diseases when taken with Vancom... |
DB00694 | DB12825 | 51 | 1,375 | [
"DDInter485",
"DDInter1032"
] | Daunorubicin | Lefamulin | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Major | 2 | [
[
[
51,
25,
1375
]
],
[
[
51,
23,
112
],
[
112,
23,
1375
]
],
[
[
51,
24,
1532
],
[
1532,
24,
1375
]
],
[
[
51,
25,
976
],
[
976,
24... | [
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lefamulin"
]
],
[
[
"Daunorubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and I... |
DB00620 | DB13074 | 175 | 877 | [
"DDInter1855",
"DDInter1110"
] | Triamcinolone | Macimorelin | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
175,
24,
877
]
],
[
[
175,
63,
1020
],
[
1020,
24,
877
]
],
[
[
175,
24,
1479
],
[
1479,
24,
877
]
],
[
[
175,
40,
1486
],
[
1486,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic ... |
DB00201 | DB00476 | 1,684 | 109 | [
"DDInter263",
"DDInter608"
] | Caffeine | Duloxetine | Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but ... | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Moderate | 1 | [
[
[
1684,
24,
109
]
],
[
[
1684,
6,
7950
],
[
7950,
45,
109
]
],
[
[
1684,
21,
29429
],
[
29429,
60,
109
]
],
[
[
1684,
23,
1387
],
[
1387... | [
[
[
"Caffeine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
]
],
[
[
"Caffeine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Caffeine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Duloxetine (Compound)
Caffeine (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Duloxetine (Compound)
Caffeine may cause a minor interaction that can limit clinical effects when taken with Terbinafine and... |
DB00539 | DB11796 | 11 | 1,612 | [
"DDInter1837",
"DDInter786"
] | Toremifene | Fostemsavir | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Major | 2 | [
[
[
11,
25,
1612
]
],
[
[
11,
63,
1051
],
[
1051,
23,
1612
]
],
[
[
11,
24,
98
],
[
98,
23,
1612
]
],
[
[
11,
24,
1476
],
[
1476,
62... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
]
],
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aminoglutethimide"
],
[
"Am... | Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide and Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Somatrem... |
DB00176 | DB00486 | 529 | 1,614 | [
"DDInter770",
"DDInter1253"
] | Fluvoxamine | Nabilone | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Moderate | 1 | [
[
[
529,
24,
1614
]
],
[
[
529,
24,
530
],
[
530,
1,
1614
]
],
[
[
529,
21,
28789
],
[
28789,
60,
1614
]
],
[
[
529,
24,
516
],
[
516,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
[
... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) resembles Nabilone (Compound)
Fluvoxamine (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Nabilone (Compound)
Fluvoxamine may cause ... |
DB00022 | DB08895 | 268 | 976 | [
"DDInter1408",
"DDInter1825"
] | Peginterferon alfa-2b | Tofacitinib | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
268,
25,
976
]
],
[
[
268,
25,
534
],
[
534,
24,
976
]
],
[
[
268,
24,
1430
],
[
1430,
24,
976
]
],
[
[
268,
24,
1580
],
[
1580,
... | [
[
[
"Peginterferon alfa-2b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tramadol"
],
[
"Tram... | Peginterferon alfa-2b may lead to a major life threatening interaction when taken with Tramadol and Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and ... |
DB00708 | DB06674 | 1,454 | 908 | [
"DDInter1718",
"DDInter837"
] | Sufentanil | Golimumab | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
1454,
24,
908
]
],
[
[
1454,
1,
704
],
[
704,
24,
908
]
],
[
[
1454,
63,
58
],
[
58,
24,
908
]
],
[
[
1454,
24,
1683
],
[
1683,
... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Sufentanil",
"{u} (Compound) resembles {v} (Compound)",
"Fentanyl"
],
[
"Fentanyl",
"{u} may cause a moderate int... | Sufentanil (Compound) resembles Fentanyl (Compound) and Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacer... |
DB00377 | DB11057 | 1,494 | 720 | [
"DDInter1382",
"DDInter1223"
] | Palonosetron | Mineral oil | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
1494,
24,
720
]
],
[
[
1494,
24,
927
],
[
927,
63,
720
]
],
[
[
1494,
24,
1151
],
[
1151,
24,
720
]
],
[
[
1494,
25,
1069
],
[
1069,
... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and ... |
DB00060 | DB00461 | 912 | 598 | [
"DDInter947",
"DDInter1254"
] | Interferon beta-1a | Nabumetone | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Moderate | 1 | [
[
[
912,
24,
598
]
],
[
[
912,
24,
1555
],
[
1555,
63,
598
]
],
[
[
912,
63,
1560
],
[
1560,
24,
598
]
],
[
[
912,
24,
482
],
[
482,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabumetone"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Nabumetone
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Peg... |
DB00342 | DB08871 | 1,181 | 36 | [
"DDInter1770",
"DDInter666"
] | Terfenadine | Eribulin | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
1181,
24,
36
]
],
[
[
1181,
23,
1247
],
[
1247,
23,
36
]
],
[
[
1181,
24,
519
],
[
519,
24,
36
]
],
[
[
1181,
25,
1424
],
[
1424,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Eribulin
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone ... |
DB01044 | DB06792 | 246 | 1,606 | [
"DDInter809",
"DDInter1023"
] | Gatifloxacin | Lanthanum carbonate | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led... | Moderate | 1 | [
[
[
246,
24,
1606
]
],
[
[
246,
1,
945
],
[
945,
24,
1606
]
],
[
[
246,
25,
1487
],
[
1487,
24,
1606
]
],
[
[
246,
24,
428
],
[
428,
... | [
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanthanum carbonate"
]
],
[
[
"Gatifloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Sparfloxacin"
],
[
"Sparfloxacin",
"{u} ma... | Gatifloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Lanthanum carbonate
Gatifloxacin may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may cause a moderate inte... |
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