drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01144 | DB01240 | 1,326 | 885 | [
"DDInter540",
"DDInter657"
] | Diclofenamide | Epoprostenol | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
1326,
24,
885
]
],
[
[
1326,
63,
1061
],
[
1061,
1,
885
]
],
[
[
1326,
6,
6017
],
[
6017,
45,
885
]
],
[
[
1326,
21,
28921
],
[
28921,... | [
[
[
"Diclofenamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Diclofenamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
]... | Diclofenamide may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Diclofenamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Epoprostenol (Compound)
Diclofenamide (Compound) causes Dizziness (Side Effe... |
DB09133 | DB09237 | 1,527 | 1,586 | [
"DDInter965",
"DDInter1045"
] | Iothalamic acid | Levamlodipine | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
1527,
24,
1586
]
],
[
[
1527,
24,
1013
],
[
1013,
63,
1586
]
],
[
[
1527,
63,
1648
],
[
1648,
24,
1586
]
],
[
[
1527,
64,
1274
],
[
12... | [
[
[
"Iothalamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Iothalamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tyropanoic aci... | Iothalamic acid may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid and Tyropanoic acid may cause a moderate interaction that could exacerbate diseases when taken with Levamlodipine
Iothalamic acid may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00557 | DB06691 | 252 | 849 | [
"DDInter895",
"DDInter1155"
] | Hydroxyzine | Mepyramine | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
252,
24,
849
]
],
[
[
252,
63,
1594
],
[
1594,
24,
849
]
],
[
[
252,
24,
272
],
[
272,
24,
849
]
],
[
[
252,
40,
11296
],
[
11296,
... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine an... |
DB00889 | DB01159 | 1,133 | 419 | [
"DDInter840",
"DDInter854"
] | Granisetron | Halothane | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Moderate | 1 | [
[
[
1133,
24,
419
]
],
[
[
1133,
6,
8374
],
[
8374,
45,
419
]
],
[
[
1133,
23,
112
],
[
112,
23,
419
]
],
[
[
1133,
63,
629
],
[
629,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halothane"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Granisetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Halothane (Compound)
Granisetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Halothane
Granisetron may ... |
DB01156 | DB01193 | 593 | 819 | [
"DDInter252",
"DDInter12"
] | Bupropion | Acebutolol | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Moderate | 1 | [
[
[
593,
24,
819
]
],
[
[
593,
63,
887
],
[
887,
1,
819
]
],
[
[
593,
6,
12523
],
[
12523,
45,
819
]
],
[
[
593,
21,
29005
],
[
29005,
... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
]
],
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
],
[
... | Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Bupropion (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Acebutolol (Compound)
Bupropion (Compound) causes Dermatitis exfoliative (Side Effect) and Der... |
DB00564 | DB08907 | 1,236 | 1,344 | [
"DDInter293",
"DDInter280"
] | Carbamazepine | Canagliflozin | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1236,
24,
1344
]
],
[
[
1236,
6,
5912
],
[
5912,
45,
1344
]
],
[
[
1236,
21,
28873
],
[
28873,
60,
1344
]
],
[
[
1236,
25,
1033
],
[
1... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Carbamazepine",
"{u} (Compound) binds {v} (Gene)",
"ABCC2"
],
[
"ABCC2",
"{u} (Gene) is bound by {v} (Comp... | Carbamazepine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Canagliflozin (Compound)
Carbamazepine (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Canagliflozin (Compound)
Carbamazepine may lead to a major life threatening interaction when taken with Alpelisib and A... |
DB06605 | DB10672 | 1,409 | 297 | [
"DDInter108",
"DDInter417"
] | Apixaban | Clove | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Clove allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
1409,
23,
297
]
],
[
[
1409,
25,
235
],
[
235,
62,
297
]
],
[
[
1409,
25,
578
],
[
578,
23,
297
]
],
[
[
1409,
64,
1564
],
[
1564,
... | [
[
[
"Apixaban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
]
],
[
[
"Apixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
],
[
"Desirudin",
"{u}... | Apixaban may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a minor interaction that can limit clinical effects when taken with Clove
Apixaban may lead to a major life threatening interaction when taken with Ticagrelor and Ticagrelor may cause a minor interaction that can... |
DB00569 | DB06754 | 553 | 707 | [
"DDInter775",
"DDInter471"
] | Fondaparinux | Danaparoid | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Major | 2 | [
[
[
553,
25,
707
]
],
[
[
553,
23,
944
],
[
944,
62,
707
]
],
[
[
553,
24,
298
],
[
298,
63,
707
]
],
[
[
553,
24,
901
],
[
901,
24,... | [
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
]
],
[
[
"Fondaparinux",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile... | Fondaparinux may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Danaparoid
Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with Protein C and Protein C... |
DB01110 | DB01244 | 86 | 762 | [
"DDInter1209",
"DDInter192"
] | Miconazole | Bepridil | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Moderate | 1 | [
[
[
86,
24,
762
]
],
[
[
86,
63,
704
],
[
704,
1,
762
]
],
[
[
86,
6,
12523
],
[
12523,
45,
762
]
],
[
[
86,
21,
28645
],
[
28645,
6... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bepridil"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Bepridil (Compound)
Miconazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bepridil (Compound)
Miconazole (Compound) causes Cough (Side Effect) and Cough (Side Effect) i... |
DB00352 | DB14409 | 482 | 1,129 | [
"DDInter1814",
"DDInter867"
] | Tioguanine | Human adenovirus e serotype 4 strain cl-68578 antigen | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
482,
24,
1129
]
],
[
[
482,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
482,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
482,
63,
1184
],
[
1184,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Tioguanine",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Tioguanine may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Tioguanine may cause a moderate interaction that could exacerbate diseases when take... |
DB00964 | DB04837 | 1,617 | 649 | [
"DDInter110",
"DDInter407"
] | Apraclonidine | Clofedanol | Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1617,
24,
649
]
],
[
[
1617,
24,
1376
],
[
1376,
24,
649
]
],
[
[
1617,
63,
832
],
[
832,
40,
649
]
],
[
[
1617,
63,
701
],
[
701,
... | [
[
[
"Apraclonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Apraclonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
... | Apraclonidine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Apraclonidine may cause a moderate interaction that could exacerbate diseases when taken with Tripe... |
DB00927 | DB01227 | 1,559 | 1,301 | [
"DDInter712",
"DDInter1043"
] | Famotidine | Levacetylmethadol | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Moderate | 1 | [
[
[
1559,
24,
1301
]
],
[
[
1559,
63,
494
],
[
494,
1,
1301
]
],
[
[
1559,
62,
112
],
[
112,
23,
1301
]
],
[
[
1559,
24,
144
],
[
144,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levacetylmethadol"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
],... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Levacetylmethadol (Compound)
Famotidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interactio... |
DB00252 | DB11186 | 362 | 1,609 | [
"DDInter1460",
"DDInter1427"
] | Phenytoin | Pentoxyverine | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
362,
24,
1609
]
],
[
[
362,
24,
104
],
[
104,
24,
1609
]
],
[
[
362,
1,
1236
],
[
1236,
24,
1609
]
],
[
[
362,
35,
1376
],
[
1376,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Phenytoin (Compound) resembles Carbamazepine (Compound) and Carbamazepine may cause a moderate interaction... |
DB06605 | DB12500 | 1,409 | 283 | [
"DDInter108",
"DDInter714"
] | Apixaban | Fedratinib | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1409,
24,
283
]
],
[
[
1409,
24,
351
],
[
351,
23,
283
]
],
[
[
1409,
63,
122
],
[
122,
23,
283
]
],
[
[
1409,
63,
1419
],
[
1419,
... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Verapamil may... |
DB00712 | DB01125 | 1,274 | 279 | [
"DDInter764",
"DDInter98"
] | Flurbiprofen (ophthalmic) | Anisindione | Flurbiprofen can cause developmental toxicity and female reproductive toxicity according to state or federal government labeling requirements. | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Moderate | 1 | [
[
[
1274,
37,
279
]
],
[
[
1274,
40,
11435
],
[
11435,
1,
279
]
],
[
[
1274,
24,
712
],
[
712,
62,
279
]
],
[
[
1274,
63,
175
],
[
175,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Anisindione"
]
],
[
[
"Flurbiprofen",
"{u} (Compound) resembles {v} (Compound)",
... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Flurbiprofen may lead to a major life threatening interaction when taken with Anisindione
Flurbiprofen (Compound) resembles Oxybenzone (Compound) and Oxybenzone (Compound) resembles Anisindione (Compound)
Flurbi... |
DB00877 | DB01599 | 629 | 1,232 | [
"DDInter1678",
"DDInter1523"
] | Sirolimus | Probucol | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Moderate | 1 | [
[
[
629,
24,
1232
]
],
[
[
629,
18,
8587
],
[
8587,
46,
1232
]
],
[
[
629,
63,
1555
],
[
1555,
24,
1232
]
],
[
[
629,
24,
927
],
[
927,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Probucol"
]
],
[
[
"Sirolimus",
"{u} (Compound) downregulates {v} (Gene)",
"RRS1"
],
[
"RRS1",
"{u} (Gene) is upregulated by {v} (Compo... | Sirolimus (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Probucol (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Probucol
Sirolimus ma... |
DB01263 | DB09020 | 859 | 28 | [
"DDInter1494",
"DDInter212"
] | Posaconazole | Bisacodyl | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
859,
24,
28
]
],
[
[
859,
21,
28666
],
[
28666,
60,
28
]
],
[
[
859,
24,
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],
[
823,
63,
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]
],
[
[
859,
63,
870
],
[
870,
24... | [
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Posaconazole",
"{u} (Compound) causes {v} (Side Effect)",
"Nervous system disorder"
],
[
"Nervous system disorder",
... | Posaconazole (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Bisacodyl (Compound)
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Triclabendazole and Triclabendazole may cause a moderate interaction that could ex... |
DB00402 | DB14723 | 1,407 | 159 | [
"DDInter685",
"DDInter1026"
] | Eszopiclone | Larotrectinib | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1407,
24,
159
]
],
[
[
1407,
24,
222
],
[
222,
23,
159
]
],
[
[
1407,
24,
98
],
[
98,
24,
159
]
],
[
[
1407,
63,
353
],
[
353,
2... | [
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Som... |
DB00384 | DB09472 | 1,275 | 1,383 | [
"DDInter1859",
"DDInter1693"
] | Triamterene | Sodium sulfate | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1275,
24,
1383
]
],
[
[
1275,
24,
104
],
[
104,
24,
1383
]
],
[
[
1275,
63,
475
],
[
475,
24,
1383
]
],
[
[
1275,
24,
407
],
[
407,
... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Morphine an... |
DB00620 | DB08907 | 175 | 1,344 | [
"DDInter1855",
"DDInter280"
] | Triamcinolone | Canagliflozin | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
175,
24,
1344
]
],
[
[
175,
24,
549
],
[
549,
1,
1344
]
],
[
[
175,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
175,
21,
28873
],
[
28873,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Triamcinolone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Triamcinolone (Compound) causes Pancreatitis (Si... |
DB00758 | DB00991 | 1,347 | 97 | [
"DDInter413",
"DDInter1358"
] | Clopidogrel | Oxaprozin | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
[
1347,
24,
97
]
],
[
[
1347,
62,
362
],
[
362,
1,
97
]
],
[
[
1347,
63,
1274
],
[
1274,
24,
97
]
],
[
[
1347,
63,
307
],
[
307,
1... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Clopidogrel",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Phenytoin"
],
[
... | Clopidogrel may cause a minor interaction that can limit clinical effects when taken with Phenytoin and Phenytoin (Compound) resembles Oxaprozin (Compound)
Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that coul... |
DB00622 | DB01110 | 1,081 | 86 | [
"DDInter1287",
"DDInter1209"
] | Nicardipine | Miconazole | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
1081,
24,
86
]
],
[
[
1081,
6,
6365
],
[
6365,
45,
86
]
],
[
[
1081,
21,
28779
],
[
28779,
60,
86
]
],
[
[
1081,
63,
1101
],
[
1101,
... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Nicardipine",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compound)... | Nicardipine (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Miconazole (Compound)
Nicardipine (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Miconazole (Compound)
Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and B... |
DB04854 | DB09122 | 1,291 | 1,613 | [
"DDInter713",
"DDInter1409"
] | Febuxostat | Peginterferon beta-1a | Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout. In the following year, the FDA for approved febuxostat for use in the chronic management of hyperuricemia in adult pat... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1291,
24,
1613
]
],
[
[
1291,
63,
267
],
[
267,
24,
1613
]
],
[
[
1291,
24,
850
],
[
850,
24,
1613
]
],
[
[
1291,
64,
328
],
[
328,
... | [
[
[
"Febuxostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Febuxostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
... | Febuxostat may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Febuxostat may cause a moderate interaction that could exacerbate diseases when taken with Brentuxima... |
DB00222 | DB01170 | 245 | 1,150 | [
"DDInter825",
"DDInter846"
] | Glimepiride | Guanethidine | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem] | Moderate | 1 | [
[
[
245,
24,
1150
]
],
[
[
245,
24,
1445
],
[
1445,
24,
1150
]
],
[
[
245,
63,
73
],
[
73,
24,
1150
]
],
[
[
245,
24,
1344
],
[
1344,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guanethidine"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
],... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Guanethidine
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Phenter... |
DB00279 | DB13257 | 1,152 | 260 | [
"DDInter1074",
"DDInter727"
] | Liothyronine | Ferrous sulfate anhydrous | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age. This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation of erythrocytes, also known as red blood cells. Ferrous sulfate is a sy... | Moderate | 1 | [
[
[
1152,
24,
260
]
],
[
[
1152,
63,
837
],
[
837,
24,
260
]
],
[
[
1152,
24,
489
],
[
489,
24,
260
]
],
[
[
1152,
1,
542
],
[
542,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous sulfate anhydrous"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pantopra... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Pantoprazole and Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Ferrous sulfate anhydrous
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01211 | DB08918 | 609 | 41 | [
"DDInter393",
"DDInter1059"
] | Clarithromycin | Levomilnacipran | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Major | 2 | [
[
[
609,
25,
41
]
],
[
[
609,
6,
10215
],
[
10215,
45,
41
]
],
[
[
609,
21,
28643
],
[
28643,
60,
41
]
],
[
[
609,
25,
498
],
[
498,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Clarithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",... | Clarithromycin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Levomilnacipran (Compound)
Clarithromycin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Levomilnacipran (Compound)
Clarithromycin may lead to a major life threatening interaction when taken with Edoxaban a... |
DB00675 | DB08916 | 888 | 26 | [
"DDInter1744",
"DDInter32"
] | Tamoxifen | Afatinib | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
888,
24,
26
]
],
[
[
888,
6,
4973
],
[
4973,
45,
26
]
],
[
[
888,
7,
16192
],
[
16192,
46,
26
]
],
[
[
888,
18,
6797
],
[
6797,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Tamoxifen",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Tamoxifen (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Afatinib (Compound)
Tamoxifen (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Afatinib (Compound)
Tamoxifen (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Afatinib (Compound)
Tamoxifen (Compound) ... |
DB08895 | DB11793 | 976 | 738 | [
"DDInter1825",
"DDInter1297"
] | Tofacitinib | Niraparib | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Major | 2 | [
[
[
976,
25,
738
]
],
[
[
976,
64,
1213
],
[
1213,
24,
738
]
],
[
[
976,
24,
496
],
[
496,
24,
738
]
],
[
[
976,
25,
1619
],
[
1619,
... | [
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Niraparib"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib",
"{u} ma... | Tofacitinib may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A V... |
DB01069 | DB06402 | 401 | 1,079 | [
"DDInter1533",
"DDInter1756"
] | Promethazine | Telavancin | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Moderate | 1 | [
[
[
401,
24,
1079
]
],
[
[
401,
21,
28775
],
[
28775,
60,
1079
]
],
[
[
401,
62,
112
],
[
112,
23,
1079
]
],
[
[
401,
63,
543
],
[
543,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
]
],
[
[
"Promethazine",
"{u} (Compound) causes {v} (Side Effect)",
"Phlebitis"
],
[
"Phlebitis",
"{u} (Side Effect) is ... | Promethazine (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Telavancin (Compound)
Promethazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with T... |
DB01041 | DB01115 | 770 | 336 | [
"DDInter1789",
"DDInter1291"
] | Thalidomide | Nifedipine | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Moderate | 1 | [
[
[
770,
24,
336
]
],
[
[
770,
63,
1428
],
[
1428,
1,
336
]
],
[
[
770,
63,
1081
],
[
1081,
40,
336
]
],
[
[
770,
6,
7950
],
[
7950,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Nifedipine (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Nifedipine (Compou... |
DB00694 | DB14409 | 51 | 1,129 | [
"DDInter485",
"DDInter867"
] | Daunorubicin | Human adenovirus e serotype 4 strain cl-68578 antigen | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
51,
24,
1129
]
],
[
[
51,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
51,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
51,
63,
134
],
[
134,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Daunorubicin may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Daunorubicin may cause a moderate interaction that could exacerbate diseases when ... |
DB00436 | DB09020 | 323 | 28 | [
"DDInter179",
"DDInter212"
] | Bendroflumethiazide | Bisacodyl | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
323,
24,
28
]
],
[
[
323,
18,
10699
],
[
10699,
57,
28
]
],
[
[
323,
21,
28809
],
[
28809,
60,
28
]
],
[
[
323,
24,
870
],
[
870,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Bendroflumethiazide",
"{u} (Compound) downregulates {v} (Gene)",
"KIF20A"
],
[
"KIF20A",
"{u} (Gene) is ... | Bendroflumethiazide (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is downregulated by Bisacodyl (Compound)
Bendroflumethiazide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Bisacodyl (Compound)
Bendroflumethiazide may cause a moderate interaction that could exacerbate dis... |
DB00580 | DB01240 | 311 | 885 | [
"DDInter1910",
"DDInter657"
] | Valdecoxib | Epoprostenol | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
311,
24,
885
]
],
[
[
311,
63,
1061
],
[
1061,
1,
885
]
],
[
[
311,
24,
1512
],
[
1512,
24,
885
]
],
[
[
311,
63,
1432
],
[
1432,
... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that... |
DB08870 | DB08873 | 850 | 74 | [
"DDInter228",
"DDInter221"
] | Brentuximab vedotin | Boceprevir | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Moderate | 1 | [
[
[
850,
24,
74
]
],
[
[
850,
63,
1374
],
[
1374,
23,
74
]
],
[
[
850,
24,
1496
],
[
1496,
63,
74
]
],
[
[
850,
63,
310
],
[
310,
24... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Boceprevir"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiratero... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Boceprevir
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Nin... |
DB00835 | DB01591 | 100 | 667 | [
"DDInter245",
"DDInter1696"
] | Brompheniramine | Solifenacin | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
100,
24,
667
]
],
[
[
100,
6,
7420
],
[
7420,
45,
667
]
],
[
[
100,
24,
830
],
[
830,
63,
667
]
],
[
[
100,
24,
104
],
[
104,
24... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Brompheniramine",
"{u} (Compound) binds {v} (Gene)",
"CHRM4"
],
[
"CHRM4",
"{u} (Gene) is bound by {v} (Co... | Brompheniramine (Compound) binds CHRM4 (Gene) and CHRM4 (Gene) is bound by Solifenacin (Compound)
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Solifenacin
Brom... |
DB01041 | DB01182 | 770 | 371 | [
"DDInter1789",
"DDInter1534"
] | Thalidomide | Propafenone | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
770,
24,
371
]
],
[
[
770,
63,
847
],
[
847,
1,
371
]
],
[
[
770,
24,
772
],
[
772,
40,
371
]
],
[
[
770,
63,
1523
],
[
1523,
40... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Propafenone (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Carvedilol and Carvedilol (Compound) resembles Propafenone (Comp... |
DB00209 | DB01021 | 352 | 674 | [
"DDInter1886",
"DDInter1861"
] | Trospium | Trichlormethiazide | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Minor | 0 | [
[
[
352,
23,
674
]
],
[
[
352,
23,
1014
],
[
1014,
40,
674
]
],
[
[
352,
23,
178
],
[
178,
1,
674
]
],
[
[
352,
24,
1507
],
[
1507,
... | [
[
[
"Trospium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trichlormethiazide"
]
],
[
[
"Trospium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Benzthiazide"
],
[
... | Trospium may cause a minor interaction that can limit clinical effects when taken with Benzthiazide and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Trospium may cause a minor interaction that can limit clinical effects when taken with Polythiazide and Polythiazide (Compound) resembles Trichlormethia... |
DB00358 | DB08864 | 1,010 | 786 | [
"DDInter1140",
"DDInter1595"
] | Mefloquine | Rilpivirine | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Moderate | 1 | [
[
[
1010,
24,
786
]
],
[
[
1010,
24,
655
],
[
655,
1,
786
]
],
[
[
1010,
6,
8374
],
[
8374,
45,
786
]
],
[
[
1010,
21,
28765
],
[
28765,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Etravirine and Etravirine (Compound) resembles Rilpivirine (Compound)
Mefloquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rilpivirine (Compound)
Mefloquine (Compound) causes Abnormal dreams (Side Effect) and A... |
DB00570 | DB00743 | 147 | 808 | [
"DDInter1936",
"DDInter792"
] | Vinblastine | Gadobenic acid | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Gadobenic acid, usually available in the salt form gadobenate dimeglumine, is a linear MRI gadolinium-based contrast agent (GBCA) used primarily for MR imaging of the liver. It differs from other GBCAs due to the benzene ring that confers weak protein binding, thus leading to an increased R1 and R2 relaxivity. As gadob... | Moderate | 1 | [
[
[
147,
24,
808
]
],
[
[
147,
21,
28769
],
[
28769,
60,
808
]
],
[
[
147,
64,
215
],
[
215,
24,
808
]
],
[
[
147,
25,
34
],
[
34,
6... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadobenic acid"
]
],
[
[
"Vinblastine",
"{u} (Compound) causes {v} (Side Effect)",
"Feeling abnormal"
],
[
"Feeling abnormal",
"{u} (... | Vinblastine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Gadobenic acid (Compound)
Vinblastine may lead to a major life threatening interaction when taken with Indinavir and Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Gado... |
DB00381 | DB09133 | 376 | 1,527 | [
"DDInter79",
"DDInter965"
] | Amlodipine | Iothalamic acid | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Moderate | 1 | [
[
[
376,
24,
1527
]
],
[
[
376,
24,
278
],
[
278,
63,
1527
]
],
[
[
376,
40,
84
],
[
84,
24,
1527
]
],
[
[
376,
1,
336
],
[
336,
24,... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopodic acid"
],
... | Amlodipine may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid and Iopodic acid may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Amlodipine (Compound) resembles Nisoldipine (Compound) and Nisoldipine may cause a moderate interaction... |
DB00072 | DB08895 | 550 | 976 | [
"DDInter1846",
"DDInter1825"
] | Trastuzumab | Tofacitinib | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
550,
25,
976
]
],
[
[
550,
24,
200
],
[
200,
63,
976
]
],
[
[
550,
24,
1430
],
[
1430,
24,
976
]
],
[
[
550,
25,
1011
],
[
1011,
... | [
[
[
"Trastuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
],
[
"C... | Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Sipule... |
DB00398 | DB11730 | 79 | 351 | [
"DDInter1702",
"DDInter1588"
] | Sorafenib | Ribociclib | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
79,
25,
351
]
],
[
[
79,
23,
1247
],
[
1247,
23,
351
]
],
[
[
79,
24,
1627
],
[
1627,
23,
351
]
],
[
[
79,
24,
861
],
[
861,
63,... | [
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Sorafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfamet... | Sorafenib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and... |
DB00049 | DB00750 | 737 | 490 | [
"DDInter1573",
"DDInter1518"
] | Rasburicase | Prilocaine | Rasburicase is a recombinant urate-oxidase enzyme produced by a genetically modified <i>Saccharomyces cerevisiae</i> strain. The cDNA coding for rasburicase was cloned from a strain of _Aspergillus flavus_. | A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165) | Major | 2 | [
[
[
737,
25,
490
]
],
[
[
737,
25,
1455
],
[
1455,
64,
490
]
],
[
[
737,
24,
384
],
[
384,
63,
608
],
[
608,
25,
490
]
],
[
[
737,
2... | [
[
[
"Rasburicase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prilocaine"
]
],
[
[
"Rasburicase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nitrous acid"
],
[
"Nitrous acid",
... | Rasburicase may lead to a major life threatening interaction when taken with Nitrous acid and Nitrous acid may lead to a major life threatening interaction when taken with Prilocaine
Rasburicase may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderat... |
DB00445 | DB00539 | 322 | 11 | [
"DDInter655",
"DDInter1837"
] | Epirubicin | Toremifene | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Major | 2 | [
[
[
322,
25,
11
]
],
[
[
322,
5,
11579
],
[
11579,
44,
11
]
],
[
[
322,
7,
4634
],
[
4634,
46,
11
]
],
[
[
322,
6,
3641
],
[
3641,
4... | [
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
]
],
[
[
"Epirubicin",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is treated by {v} (Com... | Epirubicin (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Toremifene (Compound)
Epirubicin (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Toremifene (Compound)
Epirubicin (Compound) binds DHCR7 (Gene) and DHCR7 (Gene) is upregulated by Toremifene (Compound)
E... |
DB00836 | DB00986 | 543 | 1,192 | [
"DDInter1088",
"DDInter834"
] | Loperamide | Glycopyrronium | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
543,
24,
1192
]
],
[
[
543,
35,
1511
],
[
1511,
63,
1192
]
],
[
[
543,
63,
262
],
[
262,
24,
1192
]
],
[
[
543,
18,
9579
],
[
9579,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Loperamide",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when tak... | Loperamide (Compound) resembles Mepenzolate (Compound) and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Loperamide may cause a moderate interaction tha... |
DB00744 | DB08899 | 1,288 | 129 | [
"DDInter1962",
"DDInter649"
] | Zileuton | Enzalutamide | Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, a... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1288,
24,
129
]
],
[
[
1288,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1288,
21,
28703
],
[
28703,
60,
129
]
],
[
[
1288,
25,
1510
],
[
1510... | [
[
[
"Zileuton",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Zileuton",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Zileuton (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Zileuton (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Zileuton may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may ca... |
DB00374 | DB01050 | 1,061 | 848 | [
"DDInter1852",
"DDInter900"
] | Treprostinil | Ibuprofen | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
1061,
24,
848
]
],
[
[
1061,
24,
1053
],
[
1053,
1,
848
]
],
[
[
1061,
7,
7720
],
[
7720,
45,
848
]
],
[
[
1061,
6,
6017
],
[
6017,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
],
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine and Procarbazine (Compound) resembles Ibuprofen (Compound)
Treprostinil (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Ibuprofen (Compound)
Treprostinil (Compound) binds CYP2C9 (Gene) and CYP2C9 (... |
DB00877 | DB13179 | 629 | 68 | [
"DDInter1678",
"DDInter1882"
] | Sirolimus | Troleandomycin | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | A macrolide antibiotic that is similar to erythromycin. | Major | 2 | [
[
[
629,
25,
68
]
],
[
[
629,
63,
1601
],
[
1601,
23,
68
]
],
[
[
629,
24,
222
],
[
222,
23,
68
]
],
[
[
629,
24,
973
],
[
973,
24,
... | [
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Troleandomycin"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loratadine"
],
[
"Loratadi... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Loratadine and Loratadine may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibut... |
DB00023 | DB00853 | 305 | 1,686 | [
"DDInter127",
"DDInter1762"
] | Asparaginase Escherichia coli | Temozolomide | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Moderate | 1 | [
[
[
305,
24,
1686
]
],
[
[
305,
24,
556
],
[
556,
23,
1686
]
],
[
[
305,
24,
1419
],
[
1419,
24,
1686
]
],
[
[
305,
24,
496
],
[
496,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Temozolomide"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Valproic acid and Valproic acid may cause a minor interaction that can limit clinical effects when taken with Temozolomide
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate di... |
DB01097 | DB11921 | 1,377 | 1,019 | [
"DDInter1033",
"DDInter492"
] | Leflunomide | Deflazacort | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
1377,
25,
1019
]
],
[
[
1377,
64,
1072
],
[
1072,
23,
1019
]
],
[
[
1377,
23,
1193
],
[
1193,
23,
1019
]
],
[
[
1377,
62,
1461
],
[
14... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isoniazid"
],
[
"Isoniazid",
"{u} ... | Leflunomide may lead to a major life threatening interaction when taken with Isoniazid and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Leflunomide may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may c... |
DB00282 | DB01276 | 641 | 123 | [
"DDInter1383",
"DDInter706"
] | Pamidronic acid | Exenatide | Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid]. Pamidronic acid was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic ... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
641,
24,
123
]
],
[
[
641,
24,
848
],
[
848,
24,
123
]
],
[
[
641,
1,
1199
],
[
1199,
24,
123
]
],
[
[
641,
25,
629
],
[
629,
24... | [
[
[
"Pamidronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Pamidronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
... | Pamidronic acid may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Pamidronic acid (Compound) resembles Ibandronate (Compound) and Ibandronate may cause a moderate interaction t... |
DB00653 | DB00959 | 544 | 1,486 | [
"DDInter1120",
"DDInter1191"
] | Magnesium sulfate | Methylprednisolone | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
544,
24,
1486
]
],
[
[
544,
63,
175
],
[
175,
40,
1486
]
],
[
[
544,
24,
167
],
[
167,
1,
1486
]
],
[
[
544,
63,
251
],
[
251,
1... | [
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triam... | Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compou... |
DB00186 | DB00283 | 905 | 701 | [
"DDInter1092",
"DDInter395"
] | Lorazepam | Clemastine | Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm. | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Moderate | 1 | [
[
[
905,
24,
701
]
],
[
[
905,
24,
649
],
[
649,
63,
701
]
],
[
[
905,
21,
28929
],
[
28929,
60,
701
]
],
[
[
905,
40,
695
],
[
695,
... | [
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
]
],
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Lorazepam may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Lorazepam (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Clem... |
DB00250 | DB06273 | 10 | 980 | [
"DDInter475",
"DDInter1824"
] | Dapsone | Tocilizumab | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
10,
24,
980
]
],
[
[
10,
24,
139
],
[
139,
24,
980
]
],
[
[
10,
24,
110
],
[
110,
63,
980
]
],
[
[
10,
63,
168
],
[
168,
24,
... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
],
[
"... | Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedotin and Po... |
DB01268 | DB09118 | 1,151 | 1,580 | [
"DDInter1731",
"DDInter1711"
] | Sunitinib | Stiripentol | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
1151,
24,
1580
]
],
[
[
1151,
24,
1409
],
[
1409,
24,
1580
]
],
[
[
1151,
24,
283
],
[
283,
63,
1580
]
],
[
[
1151,
63,
473
],
[
473,
... | [
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
],
[
... | Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib ... |
DB04868 | DB11057 | 478 | 720 | [
"DDInter1293",
"DDInter1223"
] | Nilotinib | Mineral oil | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
478,
24,
720
]
],
[
[
478,
25,
927
],
[
927,
63,
720
]
],
[
[
478,
63,
175
],
[
175,
24,
720
]
],
[
[
478,
64,
1151
],
[
1151,
2... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encorafeni... | Nilotinib may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may... |
DB00850 | DB06595 | 1,630 | 1,491 | [
"DDInter1432",
"DDInter1214"
] | Perphenazine | Midostaurin | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
1630,
24,
1491
]
],
[
[
1630,
23,
112
],
[
112,
23,
1491
]
],
[
[
1630,
24,
761
],
[
761,
24,
1491
]
],
[
[
1630,
63,
888
],
[
888,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Perphenazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Perphenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin an... |
DB00619 | DB00860 | 1,419 | 891 | [
"DDInter909",
"DDInter1513"
] | Imatinib | Prednisolone | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
1419,
24,
891
]
],
[
[
1419,
63,
989
],
[
989,
1,
891
]
],
[
[
1419,
24,
175
],
[
175,
40,
891
]
],
[
[
1419,
24,
1561
],
[
1561,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Progesterone"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Progesterone and Progesterone (Compound) resembles Prednisolone (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (... |
DB00827 | DB01575 | 646 | 1,054 | [
"DDInter383",
"DDInter1005"
] | Cinoxacin | Kaolin | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Moderate | 1 | [
[
[
646,
24,
1054
]
],
[
[
646,
21,
28719
],
[
28719,
60,
17
],
[
17,
23,
1054
]
],
[
[
646,
21,
29326
],
[
29326,
60,
945
],
[
945,
24,... | [
[
[
"Cinoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kaolin"
]
],
[
[
"Cinoxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Pain"
],
[
"Pain",
"{u} (Side Effect) is caused by {v} (Compo... | Cinoxacin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Sotalol (Compound) and Sotalol may cause a minor interaction that can limit clinical effects when taken with Kaolin
Cinoxacin (Compound) causes Photophobia (Side Effect) and Photophobia (Side Effect) is caused by Sparfloxacin (Compound) ... |
DB01254 | DB09472 | 1,213 | 1,383 | [
"DDInter484",
"DDInter1693"
] | Dasatinib | Sodium sulfate | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1213,
24,
1383
]
],
[
[
1213,
64,
609
],
[
609,
24,
1383
]
],
[
[
1213,
24,
643
],
[
643,
24,
1383
]
],
[
[
1213,
63,
521
],
[
521,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Clar... | Dasatinib may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desvenl... |
DB06273 | DB08826 | 980 | 1,292 | [
"DDInter1824",
"DDInter489"
] | Tocilizumab | Deferiprone | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
980,
25,
1292
]
],
[
[
980,
63,
45
],
[
45,
24,
1292
]
],
[
[
980,
23,
1193
],
[
1193,
63,
1292
]
],
[
[
980,
63,
482
],
[
482,
... | [
[
[
"Tocilizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Didanosine"
],
[
"Didanos... | Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
Tocilizumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Z... |
DB00848 | DB08868 | 281 | 1,011 | [
"DDInter1044",
"DDInter737"
] | Levamisole | Fingolimod | Levamisole is an antihelminthic drug that was commonly used for the treatment of parasitic, viral, and bacterial infections. It was manufactured by _Janssen_ and first used in 1969 as an agent to treat worm infestations Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer. Prior to this,... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
281,
25,
1011
]
],
[
[
281,
24,
748
],
[
748,
63,
1011
]
],
[
[
281,
24,
1136
],
[
1136,
24,
1011
]
],
[
[
281,
25,
976
],
[
976,
... | [
[
[
"Levamisole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Levamisole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
[
"Anthr... | Levamisole may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Levamisole may cause a moderate interaction that could exacerbate diseases when taken with Denosumab a... |
DB00169 | DB01174 | 386 | 697 | [
"DDInter367",
"DDInter1442"
] | Cholecalciferol | Phenobarbital | Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight. Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
386,
24,
697
]
],
[
[
386,
24,
759
],
[
759,
1,
697
]
],
[
[
386,
24,
536
],
[
536,
40,
697
]
],
[
[
386,
6,
7603
],
[
7603,
45,... | [
[
[
"Cholecalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Cholecalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
... | Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital (Compound) resembles Phenoba... |
DB00810 | DB01176 | 456 | 537 | [
"DDInter211",
"DDInter453"
] | Biperiden | Cyclizine | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
456,
24,
537
]
],
[
[
456,
24,
1511
],
[
1511,
63,
537
]
],
[
[
456,
63,
1242
],
[
1242,
24,
537
]
],
[
[
456,
1,
11268
],
[
11268,
... | [
[
[
"Biperiden",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Biperiden",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetiriz... |
DB00400 | DB08883 | 353 | 1,597 | [
"DDInter843",
"DDInter1428"
] | Griseofulvin | Perampanel | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning ... | Moderate | 1 | [
[
[
353,
24,
1597
]
],
[
[
353,
24,
868
],
[
868,
24,
1597
]
],
[
[
353,
24,
1320
],
[
1320,
63,
1597
]
],
[
[
353,
62,
1101
],
[
1101,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perampanel"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Perampanel
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and El... |
DB00367 | DB06273 | 566 | 980 | [
"DDInter1061",
"DDInter1824"
] | Levonorgestrel | Tocilizumab | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
566,
24,
980
]
],
[
[
566,
63,
1031
],
[
1031,
24,
980
]
],
[
[
566,
1,
1336
],
[
1336,
24,
980
]
],
[
[
566,
24,
629
],
[
629,
... | [
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
... | Levonorgestrel may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Levonorgestrel (Compound) resembles Etonogestrel (Compound) and Etonogestrel may cause a moderate inter... |
DB01097 | DB10343 | 1,377 | 962 | [
"DDInter1033",
"DDInter160"
] | Leflunomide | Bacillus calmette-guerin substrain tice live antigen | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
1377,
25,
962
]
],
[
[
1377,
25,
617
],
[
617,
24,
962
]
],
[
[
1377,
64,
1057
],
[
1057,
25,
962
]
],
[
[
1377,
25,
1342
],
[
1342,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Budesonide"
... | Leflunomide may lead to a major life threatening interaction when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Bacillus calmette-guerin substrain tice live antigen
Leflunomide may lead to a major life threatening interaction when taken with Etanerc... |
DB00938 | DB06262 | 455 | 1,354 | [
"DDInter1635",
"DDInter606"
] | Salmeterol | Droxidopa | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Droxidopa is a precursor of noradrenaline that is used in the treatment of Parkinsonism. It is approved for use in Japan and is currently in trials in the U.S. The racaemic form (dl-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a def... | Moderate | 1 | [
[
[
455,
24,
1354
]
],
[
[
455,
63,
874
],
[
874,
24,
1354
]
],
[
[
455,
24,
584
],
[
584,
40,
1354
]
],
[
[
455,
24,
1148
],
[
1148,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Droxidopa"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Droxidopa
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Levonordefrin and Le... |
DB00529 | DB00916 | 789 | 112 | [
"DDInter779",
"DDInter1202"
] | Foscarnet | Metronidazole | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
789,
23,
112
]
],
[
[
789,
21,
29310
],
[
29310,
60,
112
]
],
[
[
789,
63,
618
],
[
618,
23,
112
]
],
[
[
789,
24,
51
],
[
51,
2... | [
[
[
"Foscarnet",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Foscarnet",
"{u} (Compound) causes {v} (Side Effect)",
"Toxic epidermal necrolysis"
],
[
"Toxic epidermal necrolysis",... | Foscarnet (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Metronidazole (Compound)
Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Abarelix and Abarelix may cause a minor interaction that can limit clinical ef... |
DB01129 | DB08899 | 379 | 129 | [
"DDInter1559",
"DDInter649"
] | Rabeprazole | Enzalutamide | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
379,
24,
129
]
],
[
[
379,
6,
8374
],
[
8374,
45,
129
]
],
[
[
379,
21,
28703
],
[
28703,
60,
129
]
],
[
[
379,
63,
529
],
[
529,
... | [
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Rabeprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Rabeprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Rabeprazole (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine an... |
DB00262 | DB00532 | 552 | 208 | [
"DDInter302",
"DDInter1152"
] | Carmustine | Mephenytoin | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Moderate | 1 | [
[
[
552,
24,
208
]
],
[
[
552,
24,
1613
],
[
1613,
63,
208
]
],
[
[
552,
25,
908
],
[
908,
63,
208
]
],
[
[
552,
63,
599
],
[
599,
2... | [
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephenytoin"
]
],
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
... | Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Mephenytoin
Carmustine may lead to a major life threatening interaction when taken with Golimumab and... |
DB00902 | DB11601 | 104 | 1,270 | [
"DDInter1168",
"DDInter1889"
] | Methdilazine | Tuberculin purified protein derivative | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
104,
24,
1270
]
],
[
[
104,
63,
13
],
[
13,
24,
1270
]
],
[
[
104,
24,
1053
],
[
1053,
24,
1270
]
],
[
[
104,
40,
820
],
[
820,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Methdilazine may cause a moderate interaction that could exacerbate diseas... |
DB00215 | DB08820 | 1,230 | 1,478 | [
"DDInter388",
"DDInter997"
] | Citalopram | Ivacaftor | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Minor | 0 | [
[
[
1230,
23,
1478
]
],
[
[
1230,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
1230,
21,
29998
],
[
29998,
60,
1478
]
],
[
[
1230,
1,
318
],
[
318... | [
[
[
"Citalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ivacaftor"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Citalopram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Citalopram (Compound) causes Hyperaesthesia (Side Effect) and Hyperaesthesia (Side Effect) is caused by Ivacaftor (Compound)
Citalopram (Compound) resembles Escitalopram (Compound) and Es
Citalopram may cause a moderate interac... |
DB00059 | DB00443 | 1,560 | 251 | [
"DDInter1404",
"DDInter195"
] | Pegaspargase | Betamethasone | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Moderate | 1 | [
[
[
1560,
24,
251
]
],
[
[
1560,
24,
617
],
[
617,
40,
251
]
],
[
[
1560,
24,
167
],
[
167,
1,
251
]
],
[
[
1560,
24,
1018
],
[
1018,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Betamethasone (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Betamet... |
DB00615 | DB14723 | 690 | 159 | [
"DDInter1589",
"DDInter1026"
] | Rifabutin | Larotrectinib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Major | 2 | [
[
[
690,
25,
159
]
],
[
[
690,
24,
466
],
[
466,
23,
159
]
],
[
[
690,
25,
741
],
[
741,
24,
159
]
],
[
[
690,
24,
98
],
[
98,
24,
... | [
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Larotrectinib"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Darolut... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Rifabutin may lead to a major life threatening interaction when taken with Rolapitant and Rolapitant may cau... |
DB08870 | DB11730 | 850 | 351 | [
"DDInter228",
"DDInter1588"
] | Brentuximab vedotin | Ribociclib | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
850,
24,
351
]
],
[
[
850,
63,
1247
],
[
1247,
23,
351
]
],
[
[
850,
24,
283
],
[
283,
62,
351
]
],
[
[
850,
24,
1627
],
[
1627,
... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfameth... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when take... |
DB00816 | DB09352 | 1,674 | 373 | [
"DDInter1346",
"DDInter892"
] | Orciprenaline | Hydroxyamphetamine (ophthalmic) | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | 4-(2-aminopropyl)phenol is a member of amphetamines. | Moderate | 1 | [
[
[
1674,
24,
373
]
],
[
[
1674,
24,
480
],
[
480,
24,
373
]
],
[
[
1674,
35,
1148
],
[
1148,
24,
373
]
],
[
[
1674,
24,
480
],
[
480,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyamphetamine"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyamphetamine
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Hydroxy... |
DB00502 | DB01268 | 1,300 | 1,151 | [
"DDInter853",
"DDInter1731"
] | Haloperidol | Sunitinib | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Major | 2 | [
[
[
1300,
25,
1151
]
],
[
[
1300,
25,
1311
],
[
1311,
1,
1151
]
],
[
[
1300,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
1300,
18,
2183
],
[
2183... | [
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sunitinib"
]
],
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
],
[
"Metoclopramide",
... | Haloperidol may lead to a major life threatening interaction when taken with Metoclopramide and Metoclopramide (Compound) resembles Sunitinib (Compound)
Haloperidol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Haloperidol (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downr... |
DB00358 | DB00582 | 1,010 | 1,622 | [
"DDInter1140",
"DDInter1946"
] | Mefloquine | Voriconazole | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Moderate | 1 | [
[
[
1010,
24,
1622
]
],
[
[
1010,
6,
8374
],
[
8374,
45,
1622
]
],
[
[
1010,
21,
28957
],
[
28957,
60,
1622
]
],
[
[
1010,
23,
112
],
[
11... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Mefloquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Voriconazole (Compound)
Mefloquine (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Voriconazole (Compound)
Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole a... |
DB11817 | DB15699 | 1,259 | 652 | [
"DDInter165",
"DDInter232"
] | Baricitinib | Brexucabtagene autoleucel | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as [ibrutinib] and [acalabrutinib], the prognosis for MCL patients rem... | Major | 2 | [
[
[
1259,
25,
652
]
],
[
[
1259,
63,
810
],
[
810,
24,
652
]
],
[
[
1259,
64,
259
],
[
259,
24,
652
]
],
[
[
1259,
25,
270
],
[
270,
... | [
[
[
"Baricitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brexucabtagene autoleucel"
]
],
[
[
"Baricitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"... | Baricitinib may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89 and Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Brexucabtagene autoleucel
Baricitinib may lead to a major life threatening interaction when ta... |
DB00013 | DB00278 | 1,255 | 291 | [
"DDInter1905",
"DDInter117"
] | Urokinase | Argatroban | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Major | 2 | [
[
[
1255,
25,
291
]
],
[
[
1255,
23,
297
],
[
297,
62,
291
]
],
[
[
1255,
24,
972
],
[
972,
63,
291
]
],
[
[
1255,
24,
1230
],
[
1230,
... | [
[
[
"Urokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Argatroban"
]
],
[
[
"Urokinase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u} ... | Urokinase may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Argatroban
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate and Choline salicy... |
DB01075 | DB11642 | 1,376 | 938 | [
"DDInter569",
"DDInter1480"
] | Diphenhydramine | Pitolisant | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
1376,
24,
938
]
],
[
[
1376,
24,
760
],
[
760,
24,
938
]
],
[
[
1376,
63,
1233
],
[
1233,
24,
938
]
],
[
[
1376,
35,
820
],
[
820,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]... | Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Triprolidin... |
DB00115 | DB00585 | 227 | 1,127 | [
"DDInter451",
"DDInter1309"
] | Cyanocobalamin | Nizatidine | Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria, and is necessary for DNA synthesis and cellular energy production. Vitamin B12 has many forms, including the cyano-, met... | A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. | Minor | 0 | [
[
[
227,
23,
1127
]
],
[
[
227,
23,
1194
],
[
1194,
40,
1127
]
],
[
[
227,
1,
204
],
[
204,
21,
28763
],
[
28763,
60,
1127
]
],
[
[
227,
... | [
[
[
"Cyanocobalamin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nizatidine"
]
],
[
[
"Cyanocobalamin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
],
... | Cyanocobalamin may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranitidine (Compound) resembles Nizatidine (Compound)
Cyanocobalamin (Compound) resembles Hydroxocobalamin (Compound) and Hydroxocobalamin (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) i... |
DB00585 | DB11703 | 1,127 | 405 | [
"DDInter1309",
"DDInter9"
] | Nizatidine | Acalabrutinib | A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
1127,
24,
405
]
],
[
[
1127,
23,
1384
],
[
1384,
24,
405
]
],
[
[
1127,
24,
478
],
[
478,
24,
405
]
],
[
[
1127,
1,
1194
],
[
1194,
... | [
[
[
"Nizatidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Nizatidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
],
[
... | Nizatidine may cause a minor interaction that can limit clinical effects when taken with Magaldrate and Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Nizatidine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Niloti... |
DB00026 | DB06674 | 1,184 | 908 | [
"DDInter94",
"DDInter837"
] | Anakinra | Golimumab | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
1184,
25,
908
]
],
[
[
1184,
23,
1193
],
[
1193,
62,
908
]
],
[
[
1184,
23,
1461
],
[
1461,
23,
908
]
],
[
[
1184,
24,
336
],
[
336,
... | [
[
[
"Anakinra",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Anakinra",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc gluconat... | Anakinra may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Golimumab
Anakinra may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E ... |
DB00655 | DB01132 | 559 | 1,130 | [
"DDInter682",
"DDInter1472"
] | Estrone | Pioglitazone | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
559,
24,
1130
]
],
[
[
559,
6,
6017
],
[
6017,
45,
1130
]
],
[
[
559,
21,
28661
],
[
28661,
60,
1130
]
],
[
[
559,
1,
890
],
[
890,
... | [
[
[
"Estrone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Estrone",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Estrone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Pioglitazone (Compound)
Estrone (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Pioglitazone (Compound)
Estrone (Compound) resembles Mestranol (Compound) and Mestranol may cause a minor in... |
DB00631 | DB11791 | 372 | 785 | [
"DDInter405",
"DDInter287"
] | Clofarabine | Capmatinib | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
372,
24,
785
]
],
[
[
372,
63,
1324
],
[
1324,
24,
785
]
],
[
[
372,
24,
868
],
[
868,
24,
785
]
],
[
[
372,
24,
1320
],
[
1320,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Capmatinib
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and... |
DB06372 | DB06589 | 259 | 1,250 | [
"DDInter1594",
"DDInter1400"
] | Rilonacept | Pazopanib | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
259,
24,
1250
]
],
[
[
259,
63,
651
],
[
651,
24,
1250
]
],
[
[
259,
24,
1270
],
[
1270,
63,
1250
]
],
[
[
259,
25,
375
],
[
375,
... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
],
[
... | Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib
Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purifie... |
DB00507 | DB00842 | 316 | 686 | [
"DDInter1299",
"DDInter1359"
] | Nitazoxanide | Oxazepam | Nitazoxanide belongs to the class of drugs known as _thiazolides_. Nitazoxanide (NTZ) is a broad-spectrum anti-infective drug that markedly modulates the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, in addition to viruses.... | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Moderate | 1 | [
[
[
316,
24,
686
]
],
[
[
316,
63,
905
],
[
905,
40,
686
]
],
[
[
316,
24,
1418
],
[
1418,
1,
686
]
],
[
[
316,
63,
1174
],
[
1174,
... | [
[
[
"Nitazoxanide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxazepam"
]
],
[
[
"Nitazoxanide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorazepam"
],
[
... | Nitazoxanide may cause a moderate interaction that could exacerbate diseases when taken with Lorazepam and Lorazepam (Compound) resembles Oxazepam (Compound)
Nitazoxanide may cause a moderate interaction that could exacerbate diseases when taken with Estazolam and Estazolam (Compound) resembles Oxazepam (Compound)
Nita... |
DB00005 | DB00074 | 1,057 | 1,309 | [
"DDInter687",
"DDInter166"
] | Etanercept | Basiliximab | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermenta... | Major | 2 | [
[
[
1057,
25,
1309
]
],
[
[
1057,
23,
1461
],
[
1461,
62,
1309
]
],
[
[
1057,
25,
270
],
[
270,
63,
1309
]
],
[
[
1057,
24,
151
],
[
151,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Basiliximab"
]
],
[
[
"Etanercept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Etanercept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Basiliximab
Etanercept may lead to a major life threatening interaction when taken with Ocrelizumab and Ocrelizumab may cause a m... |
DB00813 | DB01075 | 704 | 1,376 | [
"DDInter722",
"DDInter569"
] | Fentanyl | Diphenhydramine | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
704,
35,
1376
]
],
[
[
704,
24,
649
],
[
649,
63,
1376
]
],
[
[
704,
1,
762
],
[
762,
63,
1376
]
],
[
[
704,
1,
11314
],
[
11314,
... | [
[
[
"Fentanyl",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken ... | Fentanyl (Compound) resembles Diphenhydramine (Compound) and
Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Fentanyl (Compound) resembles Bepridil (Compound... |
DB00480 | DB04865 | 1,668 | 4 | [
"DDInter1035",
"DDInter1335"
] | Lenalidomide | Omacetaxine mepesuccinate | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1668,
24,
4
]
],
[
[
1668,
6,
7720
],
[
7720,
46,
4
]
],
[
[
1668,
18,
20113
],
[
20113,
46,
4
]
],
[
[
1668,
7,
4450
],
[
4450,
... | [
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Lenalidomide",
"{u} (Compound) binds {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is upregula... | Lenalidomide (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Lenalidomide (Compound) downregulates IER3 (Gene) and IER3 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Lenalidomide (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Om... |
DB01254 | DB06209 | 1,213 | 256 | [
"DDInter484",
"DDInter1508"
] | Dasatinib | Prasugrel | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Major | 2 | [
[
[
1213,
25,
256
]
],
[
[
1213,
6,
8374
],
[
8374,
45,
256
]
],
[
[
1213,
21,
28681
],
[
28681,
60,
256
]
],
[
[
1213,
23,
944
],
[
944,
... | [
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
]
],
[
[
"Dasatinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Prasugrel"... | Dasatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Prasugrel (Compound)
Dasatinib (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Prasugrel (Compound)
Dasatinib may cause a minor interaction that can limit clinical effects when taken with Chamomile an... |
DB00842 | DB01377 | 686 | 1,283 | [
"DDInter1359",
"DDInter1119"
] | Oxazepam | Magnesium oxide | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
686,
23,
1283
]
],
[
[
686,
1,
905
],
[
905,
23,
1283
]
],
[
[
686,
40,
1174
],
[
1174,
23,
1283
]
],
[
[
686,
24,
104
],
[
104,
... | [
[
[
"Oxazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Oxazepam",
"{u} (Compound) resembles {v} (Compound)",
"Lorazepam"
],
[
"Lorazepam",
"{u} may cause a minor inte... | Oxazepam (Compound) resembles Lorazepam (Compound) and Lorazepam may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Oxazepam (Compound) resembles Temazepam (Compound) and Temazepam may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Ox... |
DB00263 | DB00563 | 1,029 | 663 | [
"DDInter1727",
"DDInter1174"
] | Sulfisoxazole | Methotrexate | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
1029,
24,
663
]
],
[
[
1029,
25,
126
],
[
126,
62,
663
]
],
[
[
1029,
1,
1247
],
[
1247,
63,
663
]
],
[
[
1029,
24,
842
],
[
842,
... | [
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Sulfisoxazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
],
[
"Warf... | Sulfisoxazole may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Sulfisoxazole (Compound) resembles Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a moderate interaction that could ... |
DB06674 | DB15044 | 908 | 631 | [
"DDInter837",
"DDInter1738"
] | Golimumab | Tafasitamab | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Tafasitamab is a humanized, CD19-directed cytolytic monoclonal antibody intended for the treatment of B-cell malignancies. It is produced using recombinant DNA technology in Chinese hamster ovary cells, and contains an IgG1/2 hybrid Fc-domain which has been modified with 2 amino acid substitutions to enhance its cytoto... | Major | 2 | [
[
[
908,
25,
631
]
],
[
[
908,
64,
4
],
[
4,
24,
631
]
],
[
[
908,
25,
270
],
[
270,
24,
631
]
],
[
[
908,
63,
597
],
[
597,
24,
... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tafasitamab"
]
],
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
],
[
"Omacetaxine... | Golimumab may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Tafasitamab
Golimumab may lead to a major life threatening interaction when taken with Ocrelizumab and Ocreli... |
DB00363 | DB01073 | 695 | 1,488 | [
"DDInter419",
"DDInter745"
] | Clozapine | Fludarabine | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Major | 2 | [
[
[
695,
25,
1488
]
],
[
[
695,
25,
1426
],
[
1426,
1,
1488
]
],
[
[
695,
25,
36
],
[
36,
63,
1488
]
],
[
[
695,
64,
134
],
[
134,
2... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludarabine"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azacitidine"
],
[
"Azacitidine",
"{u} ... | Clozapine may lead to a major life threatening interaction when taken with Azacitidine and Azacitidine (Compound) resembles Fludarabine (Compound)
Clozapine may lead to a major life threatening interaction when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00163 | DB00877 | 1,461 | 629 | [
"DDInter1943",
"DDInter1678"
] | Vitamin E | Sirolimus | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Minor | 0 | [
[
[
1461,
23,
629
]
],
[
[
1461,
6,
5998
],
[
5998,
46,
629
]
],
[
[
1461,
18,
15501
],
[
15501,
57,
629
]
],
[
[
1461,
23,
167
],
[
167,
... | [
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sirolimus"
]
],
[
[
"Vitamin E",
"{u} (Compound) binds {v} (Gene)",
"HMOX1"
],
[
"HMOX1",
"{u} (Gene) is upregulated by {v} (Compound)",
... | Vitamin E (Compound) binds HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Sirolimus (Compound)
Vitamin E (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Sirolimus (Compound)
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Hydrocortisone and Hydrocort... |
DB00188 | DB01589 | 168 | 481 | [
"DDInter222",
"DDInter1552"
] | Bortezomib | Quazepam | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors a... | Minor | 0 | [
[
[
168,
23,
481
]
],
[
[
168,
6,
10215
],
[
10215,
45,
481
]
],
[
[
168,
21,
28757
],
[
28757,
60,
481
]
],
[
[
168,
24,
283
],
[
283,
... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Quazepam"
]
],
[
[
"Bortezomib",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
... | Bortezomib (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Quazepam (Compound)
Bortezomib (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Quazepam (Compound)
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedrat... |
DB01069 | DB14568 | 401 | 982 | [
"DDInter1533",
"DDInter1000"
] | Promethazine | Ivosidenib | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
401,
25,
982
]
],
[
[
401,
24,
271
],
[
271,
23,
982
]
],
[
[
401,
62,
112
],
[
112,
23,
982
]
],
[
[
401,
63,
1081
],
[
1081,
2... | [
[
[
"Promethazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirabegron"
],
[
"Mirabe... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Promethazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Met... |
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