drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00209 | DB01400 | 352 | 1,372 | [
"DDInter1886",
"DDInter1279"
] | Trospium | Neostigmine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. | Moderate | 1 | [
[
[
352,
24,
1372
]
],
[
[
352,
24,
751
],
[
751,
40,
1372
]
],
[
[
352,
24,
61
],
[
61,
24,
1372
]
],
[
[
352,
21,
28785
],
[
28785,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neostigmine"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pyridostigmine"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Pyridostigmine and Pyridostigmine (Compound) resembles Neostigmine (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Edrophonium and Edrophonium may cause a moderate interaction tha... |
DB11640 | DB11901 | 1,267 | 913 | [
"DDInter64",
"DDInter107"
] | Amifampridine | Apalutamide | Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations. It was first discovered in Scotland in the 1970s and its clinical effectiveness for neuromuscula... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1267,
24,
913
]
],
[
[
1267,
63,
608
],
[
608,
23,
913
]
],
[
[
1267,
63,
1662
],
[
1662,
24,
913
]
],
[
[
1267,
64,
593
],
[
593,
... | [
[
[
"Amifampridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Amifampridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
... | Amifampridine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Amifampridine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid ... |
DB01227 | DB01268 | 1,301 | 1,151 | [
"DDInter1043",
"DDInter1731"
] | Levacetylmethadol | Sunitinib | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Major | 2 | [
[
[
1301,
25,
1151
]
],
[
[
1301,
24,
1311
],
[
1311,
1,
1151
]
],
[
[
1301,
6,
6799
],
[
6799,
45,
1151
]
],
[
[
1301,
62,
112
],
[
112,
... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sunitinib"
]
],
[
[
"Levacetylmethadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
[
... | Levacetylmethadol may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide (Compound) resembles Sunitinib (Compound)
Levacetylmethadol (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Sunitinib (Compound)
Levacetylmethadol may cause a minor interactio... |
DB00539 | DB06603 | 11 | 39 | [
"DDInter1837",
"DDInter1387"
] | Toremifene | Panobinostat | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
11,
25,
39
]
],
[
[
11,
23,
1247
],
[
1247,
23,
39
]
],
[
[
11,
24,
479
],
[
479,
23,
39
]
],
[
[
11,
24,
336
],
[
336,
24,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Toremifene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulf... | Toremifene may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Donepezil a... |
DB01240 | DB11071 | 885 | 1,004 | [
"DDInter657",
"DDInter1449"
] | Epoprostenol | Phenyl salicylate | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
885,
24,
1004
]
],
[
[
885,
64,
500
],
[
500,
24,
1004
]
],
[
[
885,
25,
498
],
[
498,
24,
1004
]
],
[
[
885,
24,
235
],
[
235,
... | [
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Epoprostenol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
],
[
... | Epoprostenol may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate
Epoprostenol may lead to a major life threatening interaction when taken with Edoxaban and Edoxaban may cause a modera... |
DB00519 | DB01142 | 1,638 | 1,264 | [
"DDInter1843",
"DDInter593"
] | Trandolapril | Doxepin | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1638,
24,
1264
]
],
[
[
1638,
24,
401
],
[
401,
24,
1264
]
],
[
[
1638,
21,
28898
],
[
28898,
60,
1264
]
],
[
[
1638,
63,
1648
],
[
16... | [
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[... | Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Trandolapril (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Doxepin... |
DB01100 | DB08871 | 1,568 | 36 | [
"DDInter1470",
"DDInter666"
] | Pimozide | Eribulin | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
1568,
25,
36
]
],
[
[
1568,
18,
16974
],
[
16974,
45,
36
]
],
[
[
1568,
64,
1424
],
[
1424,
24,
36
]
],
[
[
1568,
25,
820
],
[
820,
... | [
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Pimozide",
"{u} (Compound) downregulates {v} (Gene)",
"TUBB6"
],
[
"TUBB6",
"{u} (Gene) is bound by {v} (Compound)",
"Eribuli... | Pimozide (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Eribulin (Compound)
Pimozide may lead to a major life threatening interaction when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Pimozide may lead to a major life threate... |
DB01591 | DB08875 | 667 | 1,618 | [
"DDInter1696",
"DDInter262"
] | Solifenacin | Cabozantinib | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
667,
25,
1618
]
],
[
[
667,
62,
112
],
[
112,
23,
1618
]
],
[
[
667,
63,
723
],
[
723,
24,
1618
]
],
[
[
667,
25,
384
],
[
384,
... | [
[
[
"Solifenacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Solifenacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Solifenacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and ... |
DB01101 | DB11793 | 60 | 738 | [
"DDInter285",
"DDInter1297"
] | Capecitabine | Niraparib | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
60,
24,
738
]
],
[
[
60,
63,
1253
],
[
1253,
24,
738
]
],
[
[
60,
24,
496
],
[
496,
24,
738
]
],
[
[
60,
64,
770
],
[
770,
24,
... | [
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palifermin"
],
[... | Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Palifermin and Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccin... |
DB01253 | DB11730 | 628 | 351 | [
"DDInter664",
"DDInter1588"
] | Ergometrine | Ribociclib | An ergot alkaloid with uterine and vascular smooth muscle contractile properties. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
628,
24,
351
]
],
[
[
628,
24,
283
],
[
283,
62,
351
]
],
[
[
628,
63,
597
],
[
597,
24,
351
]
],
[
[
628,
24,
951
],
[
951,
24,... | [
[
[
"Ergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Ergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Ergometrine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Ergometrine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and C... |
DB00512 | DB00710 | 91 | 1,199 | [
"DDInter1916",
"DDInter897"
] | Vancomycin | Ibandronate | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatm... | Moderate | 1 | [
[
[
91,
24,
1199
]
],
[
[
91,
63,
963
],
[
963,
1,
1199
]
],
[
[
91,
21,
28719
],
[
28719,
60,
1199
]
],
[
[
91,
24,
1555
],
[
1555,
... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibandronate"
]
],
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zoledronic acid"
],
... | Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Zoledronic acid and Zoledronic acid (Compound) resembles Ibandronate (Compound)
Vancomycin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Ibandronate (Compound)
Vancomycin may cause a moderate interactio... |
DB00188 | DB08913 | 168 | 1,186 | [
"DDInter222",
"DDInter1561"
] | Bortezomib | Radium Ra 223 dichloride | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
168,
24,
1186
]
],
[
[
168,
21,
28872
],
[
28872,
60,
1186
]
],
[
[
168,
24,
134
],
[
134,
24,
1186
]
],
[
[
168,
23,
1307
],
[
1307,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Bortezomib",
"{u} (Compound) causes {v} (Side Effect)",
"Extravasation"
],
[
"Extravasation",
"{u}... | Bortezomib (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases... |
DB00450 | DB01254 | 78 | 1,213 | [
"DDInter603",
"DDInter484"
] | Droperidol | Dasatinib | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
78,
25,
1213
]
],
[
[
78,
18,
4430
],
[
4430,
57,
1213
]
],
[
[
78,
21,
28882
],
[
28882,
60,
1213
]
],
[
[
78,
23,
112
],
[
112,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Droperidol",
"{u} (Compound) downregulates {v} (Gene)",
"CHIC2"
],
[
"CHIC2",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Droperidol (Compound) downregulates CHIC2 (Gene) and CHIC2 (Gene) is downregulated by Dasatinib (Compound)
Droperidol (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasatinib (Compound)
Droperidol may cause a minor interaction that can limit clinical... |
DB00872 | DB11979 | 1,080 | 1,320 | [
"DDInter438",
"DDInter625"
] | Conivaptan | Elagolix | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Major | 2 | [
[
[
1080,
25,
1320
]
],
[
[
1080,
63,
168
],
[
168,
23,
1320
]
],
[
[
1080,
64,
608
],
[
608,
23,
1320
]
],
[
[
1080,
25,
1297
],
[
1297,
... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Elagolix"
]
],
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bortezomib",... | Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Conivaptan may lead to a major life threatening interaction when taken with Lidocaine and Lidocaine may cause a mino... |
DB00987 | DB01101 | 1,224 | 60 | [
"DDInter460",
"DDInter285"
] | Cytarabine | Capecitabine | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Moderate | 1 | [
[
[
1224,
24,
60
]
],
[
[
1224,
6,
2358
],
[
2358,
45,
60
]
],
[
[
1224,
54,
19218
],
[
19218,
15,
60
]
],
[
[
1224,
23,
872
],
[
872,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capecitabine"
]
],
[
[
"Cytarabine",
"{u} (Compound) binds {v} (Gene)",
"CDA"
],
[
"CDA",
"{u} (Gene) is bound by {v} (Compound)",
... | Cytarabine (Compound) binds CDA (Gene) and CDA (Gene) is bound by Capecitabine (Compound)
Cytarabine (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class) and Nucleic Acid Synthesis Inhibitors (Pharmacologic Class) includes Capecitabine (Compound)
Cytarabine may cause a minor interaction tha... |
DB01267 | DB01344 | 519 | 1,231 | [
"DDInter1381",
"DDInter1830"
] | Paliperidone | Tolevamer | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Moderate | 1 | [
[
[
519,
24,
1231
]
],
[
[
519,
63,
870
],
[
870,
24,
1231
]
],
[
[
519,
40,
924
],
[
924,
63,
1231
]
],
[
[
519,
24,
603
],
[
603,
... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolevamer"
]
],
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer
Paliperidone (Compound) resembles Iloperidone (Compound) and Iloperidone may cause a moderate interac... |
DB00619 | DB01174 | 1,419 | 697 | [
"DDInter909",
"DDInter1442"
] | Imatinib | Phenobarbital | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Major | 2 | [
[
[
1419,
25,
697
]
],
[
[
1419,
25,
759
],
[
759,
1,
697
]
],
[
[
1419,
64,
362
],
[
362,
1,
697
]
],
[
[
1419,
63,
536
],
[
536,
4... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenobarbital"
]
],
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primidone"
],
[
"Primidone",
"{u} (Com... | Imatinib may lead to a major life threatening interaction when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Imatinib may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compound)
Imatinib may cause a moderate in... |
DB00078 | DB01004 | 1,172 | 563 | [
"DDInter898",
"DDInter806"
] | Ibritumomab tiuxetan | Ganciclovir | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Moderate | 1 | [
[
[
1172,
24,
563
]
],
[
[
1172,
24,
248
],
[
248,
40,
563
]
],
[
[
1172,
25,
1213
],
[
1213,
63,
563
]
],
[
[
1172,
24,
869
],
[
869,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valgan... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir (Compound) resembles Ganciclovir (Compound)
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interactio... |
DB00023 | DB00095 | 305 | 66 | [
"DDInter127",
"DDInter623"
] | Asparaginase Escherichia coli | Efalizumab | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Moderate | 1 | [
[
[
305,
24,
66
]
],
[
[
305,
24,
151
],
[
151,
63,
66
]
],
[
[
305,
25,
1101
],
[
1101,
63,
66
]
],
[
[
305,
25,
581
],
[
581,
24,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) and Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) may cause a moderate interaction t... |
DB06372 | DB06810 | 259 | 397 | [
"DDInter1594",
"DDInter1484"
] | Rilonacept | Plicamycin | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Moderate | 1 | [
[
[
259,
24,
397
]
],
[
[
259,
24,
151
],
[
151,
63,
397
]
],
[
[
259,
63,
1184
],
[
1184,
24,
397
]
],
[
[
259,
24,
1430
],
[
1430,
... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Plicamycin"
]
],
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/Califor... | Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) and Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) may cause a moderate interaction that could exacerbat... |
DB00254 | DB09564 | 964 | 1,296 | [
"DDInter598",
"DDInter930"
] | Doxycycline | Insulin degludec | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
964,
24,
1296
]
],
[
[
964,
23,
674
],
[
674,
24,
1296
]
],
[
[
964,
63,
305
],
[
305,
24,
1296
]
],
[
[
964,
24,
417
],
[
417,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Doxycycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trichlormethiazide"
... | Doxycycline may cause a minor interaction that can limit clinical effects when taken with Trichlormethiazide and Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00424 | DB01267 | 19 | 519 | [
"DDInter896",
"DDInter1381"
] | Hyoscyamine | Paliperidone | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
19,
24,
519
]
],
[
[
19,
24,
1664
],
[
1664,
1,
519
]
],
[
[
19,
21,
28898
],
[
28898,
60,
519
]
],
[
[
19,
24,
1192
],
[
1192,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Hyoscyamine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Paliperidone (Compound)
Hyoscyamine may cause a modera... |
DB00092 | DB13985 | 58 | 546 | [
"DDInter40",
"DDInter1108"
] | Alefacept | Lutetium Lu 177 dotatate | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting tumours with molecules carrying radioactive particles that bind to specific receptors expressed by the tumour. Lutetium Lu 177 dot... | Moderate | 1 | [
[
[
58,
24,
546
]
],
[
[
58,
24,
66
],
[
66,
24,
546
]
],
[
[
58,
63,
1184
],
[
1184,
24,
546
]
],
[
[
58,
63,
1057
],
[
1057,
25,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lutetium Lu 177 dotatate"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Lutetium Lu 177 dotatate
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Anakinra ... |
DB09098 | DB09570 | 98 | 1,480 | [
"DDInter1700",
"DDInter1002"
] | Somatrem | Ixazomib | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate. Such discussion revolves around whether patients' natural dispo... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
98,
24,
1480
]
],
[
[
98,
63,
152
],
[
152,
24,
1480
]
],
[
[
98,
24,
1598
],
[
1598,
63,
1480
]
],
[
[
98,
62,
168
],
[
168,
24... | [
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosentan"
],
[
"Bos... | Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Bosentan and Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat and Tazemetostat m... |
DB00798 | DB09133 | 1,132 | 1,527 | [
"DDInter815",
"DDInter965"
] | Gentamicin | Iothalamic acid | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Major | 2 | [
[
[
1132,
25,
1527
]
],
[
[
1132,
64,
1028
],
[
1028,
24,
1527
]
],
[
[
1132,
24,
242
],
[
242,
63,
1527
]
],
[
[
1132,
25,
1680
],
[
1680... | [
[
[
"Gentamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Gentamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Torasemide"
],
[
"Torasemide",
"... | Gentamicin may lead to a major life threatening interaction when taken with Torasemide and Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may c... |
DB01230 | DB08824 | 795 | 591 | [
"DDInter1416",
"DDInter959"
] | Pemoline | Ioflupane I-123 | In 2005, the Food and Drug Administration (FDA) withdrew approval for pemoline. In March 2005, Abbott Laboratories (Cylert marketer) had discontinued the production of Cylert arguing economic reasons. | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
795,
24,
591
]
],
[
[
795,
63,
401
],
[
401,
24,
591
]
],
[
[
795,
64,
593
],
[
593,
24,
591
]
],
[
[
795,
64,
290
],
[
290,
35,... | [
[
[
"Pemoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Pemoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[... | Pemoline may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Pemoline may lead to a major life threatening interaction when taken with Bupropion and Bupropion may cau... |
DB05679 | DB10583 | 1,683 | 949 | [
"DDInter1907",
"DDInter415"
] | Ustekinumab | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
1683,
24,
949
]
],
[
[
1683,
63,
550
],
[
550,
24,
949
]
],
[
[
1683,
24,
250
],
[
250,
24,
949
]
],
[
[
1683,
64,
1377
],
[
1377,
... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab and Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Ustekinumab may cause a moderate interaction that could exa... |
DB01030 | DB08826 | 869 | 1,292 | [
"DDInter1835",
"DDInter489"
] | Topotecan | Deferiprone | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
869,
25,
1292
]
],
[
[
869,
18,
2215
],
[
2215,
57,
1292
]
],
[
[
869,
21,
28809
],
[
28809,
60,
1292
]
],
[
[
869,
24,
72
],
[
72,
... | [
[
[
"Topotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Topotecan",
"{u} (Compound) downregulates {v} (Gene)",
"HSPA8"
],
[
"HSPA8",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Topotecan (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Deferiprone (Compound)
Topotecan (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Deferiprone (Compound)
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Eltrom... |
DB00486 | DB01115 | 1,614 | 336 | [
"DDInter1253",
"DDInter1291"
] | Nabilone | Nifedipine | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Moderate | 1 | [
[
[
1614,
24,
336
]
],
[
[
1614,
63,
1428
],
[
1428,
1,
336
]
],
[
[
1614,
24,
1081
],
[
1081,
40,
336
]
],
[
[
1614,
24,
409
],
[
409,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Nifedipine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Nifedipine (Compound)
Na... |
DB00023 | DB11363 | 305 | 1,276 | [
"DDInter127",
"DDInter39"
] | Asparaginase Escherichia coli | Alectinib | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
305,
24,
1276
]
],
[
[
305,
25,
1011
],
[
1011,
24,
1276
]
],
[
[
305,
24,
850
],
[
850,
24,
1276
]
],
[
[
305,
24,
242
],
[
242,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingo... | Asparaginase Escherichia coli may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00603 | DB06414 | 303 | 655 | [
"DDInter1137",
"DDInter703"
] | Medroxyprogesterone acetate | Etravirine | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
303,
24,
655
]
],
[
[
303,
6,
6017
],
[
6017,
45,
655
]
],
[
[
303,
21,
28723
],
[
28723,
60,
655
]
],
[
[
303,
64,
1101
],
[
1101,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (... | Medroxyprogesterone acetate (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Etravirine (Compound)
Medroxyprogesterone acetate (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Etravirine (Compound)
Medroxyprogesterone acetate may lead to a major life threatening inter... |
DB00009 | DB11071 | 1,271 | 1,004 | [
"DDInter56",
"DDInter1449"
] | Alteplase | Phenyl salicylate | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
1271,
24,
1004
]
],
[
[
1271,
25,
500
],
[
500,
24,
1004
]
],
[
[
1271,
25,
235
],
[
235,
63,
1004
]
],
[
[
1271,
24,
885
],
[
885,
... | [
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Alteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
],
[
"Enoxa... | Alteplase may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate
Alteplase may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a moderate i... |
DB00738 | DB01067 | 485 | 959 | [
"DDInter1420",
"DDInter826"
] | Pentamidine | Glipizide | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
485,
24,
959
]
],
[
[
485,
63,
245
],
[
245,
40,
959
]
],
[
[
485,
24,
1411
],
[
1411,
1,
959
]
],
[
[
485,
6,
8374
],
[
8374,
4... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compou... |
DB08870 | DB08901 | 850 | 1,468 | [
"DDInter228",
"DDInter1492"
] | Brentuximab vedotin | Ponatinib | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
850,
24,
1468
]
],
[
[
850,
63,
478
],
[
478,
24,
1468
]
],
[
[
850,
24,
987
],
[
987,
63,
1468
]
],
[
[
850,
24,
129
],
[
129,
... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Vibrio... |
DB00349 | DB06273 | 902 | 980 | [
"DDInter401",
"DDInter1824"
] | Clobazam | Tocilizumab | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
902,
24,
980
]
],
[
[
902,
62,
1031
],
[
1031,
24,
980
]
],
[
[
902,
24,
597
],
[
597,
24,
980
]
],
[
[
902,
63,
58
],
[
58,
24,... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Clobazam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Theophylline"
],
[
... | Clobazam may cause a minor interaction that can limit clinical effects when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Ch... |
DB00445 | DB11791 | 322 | 785 | [
"DDInter655",
"DDInter287"
] | Epirubicin | Capmatinib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
322,
24,
785
]
],
[
[
322,
25,
868
],
[
868,
24,
785
]
],
[
[
322,
63,
482
],
[
482,
24,
785
]
],
[
[
322,
24,
866
],
[
866,
24,... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
],
[
"Vemurafen... | Epirubicin may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Capmatinib
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may caus... |
DB00708 | DB01114 | 1,454 | 272 | [
"DDInter1718",
"DDInter362"
] | Sufentanil | Chlorpheniramine | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
1454,
24,
272
]
],
[
[
1454,
24,
849
],
[
849,
63,
272
]
],
[
[
1454,
63,
128
],
[
128,
24,
272
]
],
[
[
1454,
6,
8374
],
[
8374,
... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniram... |
DB00470 | DB00555 | 530 | 706 | [
"DDInter601",
"DDInter1020"
] | Dronabinol | Lamotrigine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It... | Moderate | 1 | [
[
[
530,
24,
706
]
],
[
[
530,
63,
1275
],
[
1275,
1,
706
]
],
[
[
530,
6,
4973
],
[
4973,
45,
706
]
],
[
[
530,
21,
28769
],
[
28769,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lamotrigine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamterene"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Triamterene and Triamterene (Compound) resembles Lamotrigine (Compound)
Dronabinol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lamotrigine (Compound)
Dronabinol (Compound) causes Feeling abnormal (Side Effect) and ... |
DB04837 | DB08815 | 649 | 154 | [
"DDInter407",
"DDInter1104"
] | Clofedanol | Lurasidone | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
649,
24,
154
]
],
[
[
649,
63,
1242
],
[
1242,
24,
154
]
],
[
[
649,
74,
662
],
[
662,
24,
154
]
],
[
[
649,
1,
820
],
[
820,
24... | [
[
[
"Clofedanol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Clofedanol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],
[
... | Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone
Clofedanol (Compound) resembles Carbinoxamine (Compound) and Clofedanol may cause a moderate interaction that co... |
DB00635 | DB11714 | 1,573 | 1,316 | [
"DDInter1515",
"DDInter610"
] | Prednisone | Durvalumab | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote... | Moderate | 1 | [
[
[
1573,
24,
1316
]
],
[
[
1573,
62,
1461
],
[
1461,
23,
1316
]
],
[
[
1573,
23,
1114
],
[
1114,
23,
1316
]
],
[
[
1573,
40,
167
],
[
167... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Durvalumab"
]
],
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Prednisone may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Durvalumab
Prednisone may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate... |
DB00782 | DB00808 | 1,123 | 1,605 | [
"DDInter1535",
"DDInter916"
] | Propantheline | Indapamide | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Minor | 0 | [
[
[
1123,
23,
1605
]
],
[
[
1123,
62,
811
],
[
811,
1,
1605
]
],
[
[
1123,
21,
28671
],
[
28671,
60,
1605
]
],
[
[
1123,
24,
1511
],
[
151... | [
[
[
"Propantheline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Indapamide"
]
],
[
[
"Propantheline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metolazone"
],
[
... | Propantheline may cause a minor interaction that can limit clinical effects when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound)
Propantheline (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Indapamide (Compound)
Propantheline may cause a moderate inter... |
DB00197 | DB00843 | 1,324 | 479 | [
"DDInter1881",
"DDInter583"
] | Troglitazone | Donepezil | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
1324,
24,
479
]
],
[
[
1324,
24,
723
],
[
723,
23,
479
]
],
[
[
1324,
24,
392
],
[
392,
62,
479
]
],
[
[
1324,
24,
1010
],
[
1010,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a minor interaction that can limit clinical effects when taken with Donepezil
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapati... |
DB01030 | DB06603 | 869 | 39 | [
"DDInter1835",
"DDInter1387"
] | Topotecan | Panobinostat | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
869,
24,
39
]
],
[
[
869,
63,
1257
],
[
1257,
24,
39
]
],
[
[
869,
24,
221
],
[
221,
63,
39
]
],
[
[
869,
24,
1683
],
[
1683,
24... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegfilgrastim"
],
[... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Pegfilgrastim and Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type... |
DB00031 | DB00533 | 20 | 1,416 | [
"DDInter1764",
"DDInter1613"
] | Tenecteplase | Rofecoxib | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Moderate | 1 | [
[
[
20,
24,
1416
]
],
[
[
20,
25,
1409
],
[
1409,
63,
1416
]
],
[
[
20,
64,
1578
],
[
1578,
24,
1416
]
],
[
[
20,
24,
714
],
[
714,
... | [
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rofecoxib"
]
],
[
[
"Tenecteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
],
[
"Apixaban"... | Tenecteplase may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Rofecoxib
Tenecteplase may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interac... |
DB00774 | DB00860 | 1,577 | 891 | [
"DDInter889",
"DDInter1513"
] | Hydroflumethiazide | Prednisolone | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
1577,
24,
891
]
],
[
[
1577,
63,
175
],
[
175,
40,
891
]
],
[
[
1577,
63,
167
],
[
167,
1,
891
]
],
[
[
1577,
24,
1220
],
[
1220,
... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcino... | Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)
Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) ... |
DB00903 | DB01284 | 1,680 | 1,042 | [
"DDInter686",
"DDInter1782"
] | Etacrynic acid | Tetracosactide | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1680,
24,
1042
]
],
[
[
1680,
24,
455
],
[
455,
23,
1042
]
],
[
[
1680,
24,
659
],
[
659,
62,
1042
]
],
[
[
1680,
63,
1674
],
[
1674,
... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
... | Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol ... |
DB00782 | DB06016 | 1,123 | 1,508 | [
"DDInter1535",
"DDInter300"
] | Propantheline | Cariprazine | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
1123,
24,
1508
]
],
[
[
1123,
24,
1507
],
[
1507,
24,
1508
]
],
[
[
1123,
63,
1442
],
[
1442,
24,
1508
]
],
[
[
1123,
24,
849
],
[
849... | [
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
],
... | Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine and Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine ... |
DB01129 | DB01416 | 379 | 1,024 | [
"DDInter1559",
"DDInter326"
] | Rabeprazole | Cefpodoxime | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Cefpodoxime is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime. | Moderate | 1 | [
[
[
379,
24,
1024
]
],
[
[
379,
63,
665
],
[
665,
40,
1024
]
],
[
[
379,
63,
1462
],
[
1462,
1,
1024
]
],
[
[
379,
21,
29119
],
[
29119,
... | [
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefpodoxime"
]
],
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefuroxime"
],
[... | Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Cefuroxime and Cefuroxime (Compound) resembles Cefpodoxime (Compound)
Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Cefditoren and Cefditoren (Compound) resembles Cefpodoxime (Compou... |
DB00861 | DB01097 | 914 | 1,377 | [
"DDInter551",
"DDInter1033"
] | Diflunisal | Leflunomide | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
914,
25,
1377
]
],
[
[
914,
10,
11577
],
[
11577,
44,
1377
]
],
[
[
914,
21,
28864
],
[
28864,
60,
1377
]
],
[
[
914,
64,
126
],
[
126... | [
[
[
"Diflunisal",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Diflunisal",
"{u} (Compound) palliates {v} (Disease)",
"rheumatoid arthritis"
],
[
"rheumatoid arthritis",
"{u} (Disease) is t... | Diflunisal (Compound) palliates rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Leflunomide (Compound)
Diflunisal (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Leflunomide (Compound)
Diflunisal may lead to a major life threatening ... |
DB00497 | DB00771 | 828 | 262 | [
"DDInter1366",
"DDInter397"
] | Oxycodone | Clidinium | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Moderate | 1 | [
[
[
828,
24,
262
]
],
[
[
828,
24,
1511
],
[
1511,
63,
262
]
],
[
[
828,
63,
19
],
[
19,
24,
262
]
],
[
[
828,
40,
314
],
[
314,
63,... | [
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clidinium"
]
],
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscy... |
DB00731 | DB13928 | 1,144 | 1,385 | [
"DDInter1269",
"DDInter1660"
] | Nateglinide | Semaglutide | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
1144,
24,
1385
]
],
[
[
1144,
62,
1103
],
[
1103,
23,
1385
]
],
[
[
1144,
24,
1154
],
[
1154,
24,
1385
]
],
[
[
1144,
24,
1399
],
[
13... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Nateglinide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
[
... | Nateglinide may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Semaglutide
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Pasireotide and Pasire... |
DB00860 | DB06292 | 891 | 549 | [
"DDInter1513",
"DDInter474"
] | Prednisolone | Dapagliflozin | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
891,
24,
549
]
],
[
[
891,
24,
1344
],
[
1344,
40,
549
]
],
[
[
891,
6,
8717
],
[
8717,
45,
549
]
],
[
[
891,
21,
28787
],
[
28787,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Prednisolone (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Dapagliflozin (Compound)
Prednisolone (Compound) causes Dermatitis (Side Ef... |
DB01200 | DB06663 | 469 | 1,154 | [
"DDInter243",
"DDInter1398"
] | Bromocriptine | Pasireotide | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Moderate | 1 | [
[
[
469,
24,
1154
]
],
[
[
469,
63,
966
],
[
966,
40,
1154
]
],
[
[
469,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
469,
40,
826
],
[
826,
... | [
[
[
"Bromocriptine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
]
],
[
[
"Bromocriptine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
... | Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Bromocriptine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Bromocriptine (Compound) r... |
DB00836 | DB13179 | 543 | 68 | [
"DDInter1088",
"DDInter1882"
] | Loperamide | Troleandomycin | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | A macrolide antibiotic that is similar to erythromycin. | Major | 2 | [
[
[
543,
25,
68
]
],
[
[
543,
1,
1413
],
[
1413,
23,
68
]
],
[
[
543,
25,
1374
],
[
1374,
23,
68
]
],
[
[
543,
24,
412
],
[
412,
24,... | [
[
[
"Loperamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Troleandomycin"
]
],
[
[
"Loperamide",
"{u} (Compound) resembles {v} (Compound)",
"Fexofenadine"
],
[
"Fexofenadine",
"{u} may cause a minor interact... | Loperamide (Compound) resembles Fexofenadine (Compound) and Fexofenadine may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Loperamide may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clini... |
DB00374 | DB01203 | 1,061 | 699 | [
"DDInter1852",
"DDInter1255"
] | Treprostinil | Nadolol | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Moderate | 1 | [
[
[
1061,
35,
699
]
],
[
[
1061,
24,
729
],
[
729,
1,
699
]
],
[
[
1061,
18,
3576
],
[
3576,
45,
699
]
],
[
[
1061,
18,
6818
],
[
6818,
... | [
[
[
"Treprostinil",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nadolol"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken ... | Treprostinil (Compound) resembles Nadolol (Compound) and
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Penbutolol and Penbutolol (Compound) resembles Nadolol (Compound)
Treprostinil (Compound) downregulates ADRB2 (Gene) and ADRB2 (Gene) is bound by Nadolol (Compound)
Trepr... |
DB00060 | DB00459 | 912 | 640 | [
"DDInter947",
"DDInter21"
] | Interferon beta-1a | Acitretin | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. | Moderate | 1 | [
[
[
912,
24,
640
]
],
[
[
912,
24,
1517
],
[
1517,
64,
640
]
],
[
[
912,
24,
637
],
[
637,
63,
640
]
],
[
[
912,
63,
305
],
[
305,
2... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acitretin"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isotretinoin... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin may lead to a major life threatening interaction when taken with Acitretin
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwi... |
DB00843 | DB09080 | 479 | 144 | [
"DDInter583",
"DDInter1331"
] | Donepezil | Olodaterol | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
479,
24,
144
]
],
[
[
479,
24,
1011
],
[
1011,
24,
144
]
],
[
[
479,
63,
11
],
[
11,
24,
144
]
],
[
[
479,
23,
1250
],
[
1250,
2... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
],
[
... | Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and Toremife... |
DB00283 | DB01178 | 701 | 369 | [
"DDInter395",
"DDInter357"
] | Clemastine | Chlormezanone | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. | Moderate | 1 | [
[
[
701,
24,
369
]
],
[
[
701,
18,
4930
],
[
4930,
57,
369
]
],
[
[
701,
24,
1532
],
[
1532,
63,
369
]
],
[
[
701,
24,
272
],
[
272,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlormezanone"
]
],
[
[
"Clemastine",
"{u} (Compound) downregulates {v} (Gene)",
"DLD"
],
[
"DLD",
"{u} (Gene) is downregulated by {v}... | Clemastine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Chlormezanone (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Chlormezanone
Cl... |
DB00685 | DB06203 | 1,299 | 1,002 | [
"DDInter1887",
"DDInter51"
] | Trovafloxacin | Alogliptin | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
1299,
24,
1002
]
],
[
[
1299,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
1299,
21,
28873
],
[
28873,
60,
1002
]
],
[
[
1299,
64,
176
],
[
1... | [
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
... | Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Trovafloxacin (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Alogliptin (Compound)
Trovafloxacin may lead to a ma... |
DB01208 | DB04272 | 945 | 442 | [
"DDInter1705",
"DDInter390"
] | Sparfloxacin | Citric acid | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium-chelating ability. Citric acid is one of the active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020. ... | Moderate | 1 | [
[
[
945,
24,
442
]
],
[
[
945,
40,
1176
],
[
1176,
24,
442
]
],
[
[
945,
24,
115
],
[
115,
64,
442
]
],
[
[
945,
40,
1176
],
[
1176,
... | [
[
[
"Sparfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citric acid"
]
],
[
[
"Sparfloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Moxifloxacin"
],
[
"Moxifloxacin",
"{u} may cause ... | Sparfloxacin (Compound) resembles Moxifloxacin (Compound) and Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Citric acid
Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Aluminum hydroxide and Aluminum hydroxide may lead to a majo... |
DB00620 | DB01320 | 175 | 651 | [
"DDInter1855",
"DDInter783"
] | Triamcinolone | Fosphenytoin | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
175,
24,
651
]
],
[
[
175,
23,
307
],
[
307,
1,
651
]
],
[
[
175,
63,
362
],
[
362,
1,
651
]
],
[
[
175,
24,
998
],
[
998,
1,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Triamcinolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
... | Triamcinolone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Fosphenytoin (Compound)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compou... |
DB00531 | DB10795 | 450 | 221 | [
"DDInter456",
"DDInter1486"
] | Cyclophosphamide | Poliovirus type 1 antigen (formaldehyde inactivated) | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
450,
24,
221
]
],
[
[
450,
64,
581
],
[
581,
24,
221
]
],
[
[
450,
63,
599
],
[
599,
24,
221
]
],
[
[
450,
24,
1531
],
[
1531,
2... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Cyclophosphamide",
"{u} may lead to a major life threatening interaction when taken with {... | Cyclophosphamide may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Cyclophosphamide may cause a moderate interaction that could exacerbate disease... |
DB00060 | DB01125 | 912 | 279 | [
"DDInter947",
"DDInter98"
] | Interferon beta-1a | Anisindione | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Moderate | 1 | [
[
[
912,
24,
279
]
],
[
[
912,
24,
1647
],
[
1647,
23,
279
]
],
[
[
912,
24,
918
],
[
918,
62,
279
]
],
[
[
912,
24,
780
],
[
780,
6... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Anisindione
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Bicalutami... |
DB01181 | DB06204 | 1,532 | 768 | [
"DDInter906",
"DDInter1746"
] | Ifosfamide | Tapentadol | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Moderate | 1 | [
[
[
1532,
24,
768
]
],
[
[
1532,
6,
10215
],
[
10215,
45,
768
]
],
[
[
1532,
21,
29922
],
[
29922,
60,
768
]
],
[
[
1532,
63,
717
],
[
717... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tapentadol"
]
],
[
[
"Ifosfamide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)... | Ifosfamide (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Tapentadol (Compound)
Ifosfamide (Compound) causes Panic attack (Side Effect) and Panic attack (Side Effect) is caused by Tapentadol (Compound)
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Trimethoben... |
DB01320 | DB09039 | 651 | 1,670 | [
"DDInter783",
"DDInter629"
] | Fosphenytoin | Eliglustat | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Major | 2 | [
[
[
651,
25,
1670
]
],
[
[
651,
25,
1135
],
[
1135,
62,
1670
]
],
[
[
651,
25,
1409
],
[
1409,
24,
1670
]
],
[
[
651,
63,
322
],
[
322,
... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eliglustat"
]
],
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u}... | Fosphenytoin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Eliglustat
Fosphenytoin may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate interact... |
DB00978 | DB01278 | 739 | 1,021 | [
"DDInter1084",
"DDInter1506"
] | Lomefloxacin | Pramlintide | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
739,
24,
1021
]
],
[
[
739,
1,
1539
],
[
1539,
24,
1021
]
],
[
[
739,
64,
891
],
[
891,
24,
1021
]
],
[
[
739,
25,
1019
],
[
1019,
... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Lomefloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Ofloxacin"
],
[
"Ofloxacin",
"{u} may cause a mode... | Lomefloxacin (Compound) resembles Ofloxacin (Compound) and Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Lomefloxacin may lead to a major life threatening interaction when taken with Prednisolone and Prednisolone may cause a moderate interaction that could exacerb... |
DB00059 | DB08895 | 1,560 | 976 | [
"DDInter1404",
"DDInter1825"
] | Pegaspargase | Tofacitinib | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
1560,
25,
976
]
],
[
[
1560,
24,
200
],
[
200,
63,
976
]
],
[
[
1560,
24,
998
],
[
998,
24,
976
]
],
[
[
1560,
25,
1011
],
[
1011,
... | [
[
[
"Pegaspargase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
],
[
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Phen... |
DB00501 | DB00802 | 752 | 1,322 | [
"DDInter380",
"DDInter43"
] | Cimetidine | Alfentanil | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Moderate | 1 | [
[
[
752,
24,
1322
]
],
[
[
752,
24,
411
],
[
411,
1,
1322
]
],
[
[
752,
6,
6799
],
[
6799,
45,
1322
]
],
[
[
752,
21,
29118
],
[
29118,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alfentanil"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remifentanil"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Remifentanil and Remifentanil (Compound) resembles Alfentanil (Compound)
Cimetidine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Alfentanil (Compound)
Cimetidine (Compound) causes Tachycardia (Side Effect) and Tac... |
DB01175 | DB06589 | 318 | 1,250 | [
"DDInter672",
"DDInter1400"
] | Escitalopram | Pazopanib | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Major | 2 | [
[
[
318,
25,
1250
]
],
[
[
318,
6,
12523
],
[
12523,
45,
1250
]
],
[
[
318,
18,
5587
],
[
5587,
46,
1250
]
],
[
[
318,
21,
29264
],
[
2926... | [
[
[
"Escitalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pazopanib"
]
],
[
[
"Escitalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Pazo... | Escitalopram (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pazopanib (Compound)
Escitalopram (Compound) downregulates SCAND1 (Gene) and SCAND1 (Gene) is upregulated by Pazopanib (Compound)
Escitalopram (Compound) causes Rhinorrhoea (Side Effect) and Rhinorrhoea (Side Effect) is caused by Pazopanib (Compo... |
DB09280 | DB11757 | 1,604 | 960 | [
"DDInter1101",
"DDInter994"
] | Lumacaftor | Istradefylline | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Istradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A<sub>2A</sub> receptors in the basal ganglia. This region of the brain is highly in... | Major | 2 | [
[
[
1604,
25,
960
]
],
[
[
1604,
64,
1135
],
[
1135,
23,
960
]
],
[
[
1604,
25,
1499
],
[
1499,
24,
960
]
],
[
[
1604,
64,
1374
],
[
1374,... | [
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Istradefylline"
]
],
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u}... | Lumacaftor may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Istradefylline
Lumacaftor may lead to a major life threatening interaction when taken with Naldemedine and Naldemedine may cause a moderate in... |
DB01118 | DB09054 | 33 | 384 | [
"DDInter76",
"DDInter905"
] | Amiodarone | Idelalisib | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
33,
24,
384
]
],
[
[
33,
25,
1618
],
[
1618,
24,
384
]
],
[
[
33,
63,
58
],
[
58,
24,
384
]
],
[
[
33,
64,
888
],
[
888,
24,
... | [
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
],
[
"Cabozant... | Amiodarone may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may caus... |
DB06626 | DB08912 | 263 | 1,040 | [
"DDInter147",
"DDInter462"
] | Axitinib | Dabrafenib | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Major | 2 | [
[
[
263,
25,
1040
]
],
[
[
263,
63,
1101
],
[
1101,
23,
1040
]
],
[
[
263,
63,
478
],
[
478,
24,
1040
]
],
[
[
263,
24,
1478
],
[
1478,
... | [
[
[
"Axitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dabrafenib"
]
],
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",
... | Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Dabrafenib
Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may... |
DB06207 | DB08881 | 910 | 868 | [
"DDInter1667",
"DDInter1925"
] | Silodosin | Vemurafenib | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
910,
24,
868
]
],
[
[
910,
6,
8374
],
[
8374,
45,
868
]
],
[
[
910,
21,
28714
],
[
28714,
60,
868
]
],
[
[
910,
24,
578
],
[
578,
... | [
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Silodosin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Silodosin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Silodosin (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Vemurafenib (Compound)
Silodosin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagre... |
DB00552 | DB10316 | 1,238 | 334 | [
"DDInter1425",
"DDInter1248"
] | Pentostatin | Mumps virus strain B level jeryl lynn live antigen | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1238,
25,
334
]
],
[
[
1238,
64,
1057
],
[
1057,
25,
334
]
],
[
[
1238,
24,
328
],
[
328,
25,
334
]
],
[
[
1238,
25,
908
],
[
908,
... | [
[
[
"Pentostatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Pentostatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Pentostatin may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Mercaptop... |
DB00691 | DB08870 | 1,058 | 850 | [
"DDInter1237",
"DDInter228"
] | Moexipril | Brentuximab vedotin | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1058,
24,
850
]
],
[
[
1058,
24,
267
],
[
267,
24,
850
]
],
[
[
1058,
63,
1512
],
[
1512,
24,
850
]
],
[
[
1058,
24,
1344
],
[
1344,
... | [
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
... | Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and... |
DB00701 | DB11978 | 1,091 | 124 | [
"DDInter90",
"DDInter822"
] | Amprenavir | Glasdegib | Amprenavir is a protease inhibitor used to treat HIV infection. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1091,
24,
124
]
],
[
[
1091,
25,
1135
],
[
1135,
23,
124
]
],
[
[
1091,
23,
466
],
[
466,
62,
124
]
],
[
[
1091,
24,
26
],
[
26,
... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Amprenavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Amprenavir may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a m... |
DB01097 | DB14730 | 1,377 | 1,412 | [
"DDInter1033",
"DDInter264"
] | Leflunomide | Calaspargase pegol | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Major | 2 | [
[
[
1377,
25,
1412
]
],
[
[
1377,
25,
250
],
[
250,
24,
1412
]
],
[
[
1377,
64,
883
],
[
883,
24,
1412
]
],
[
[
1377,
63,
1144
],
[
1144,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Blinatumomab"
],
[
"Blinatumomab"... | Leflunomide may lead to a major life threatening interaction when taken with Blinatumomab and Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Leflunomide may lead to a major life threatening interaction when taken with Gefitinib and Gefitinib may cause a m... |
DB00284 | DB00685 | 1,647 | 1,299 | [
"DDInter11",
"DDInter1887"
] | Acarbose | Trovafloxacin | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Moderate | 1 | [
[
[
1647,
24,
1299
]
],
[
[
1647,
24,
872
],
[
872,
40,
1299
]
],
[
[
1647,
21,
28845
],
[
28845,
60,
1299
]
],
[
[
1647,
24,
322
],
[
322... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trovafloxacin"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Acarbose (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Trovafloxacin (Compound)
Acarbose may cause a moderate interaction th... |
DB00556 | DB01166 | 1,262 | 477 | [
"DDInter1429",
"DDInter379"
] | Perflutren | Cilostazol | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
1262,
24,
477
]
],
[
[
1262,
21,
28892
],
[
28892,
60,
477
]
],
[
[
1262,
23,
112
],
[
112,
23,
477
]
],
[
[
1262,
24,
820
],
[
820,
... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Perflutren",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac arrest"
],
[
"Cardiac arrest",
"{u} (Side Effec... | Perflutren (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Cilostazol (Compound)
Perflutren may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken ... |
DB09065 | DB11575 | 760 | 1,676 | [
"DDInter424",
"DDInter841"
] | Cobicistat | Grazoprevir | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common i... | Major | 2 | [
[
[
760,
25,
1676
]
],
[
[
760,
63,
723
],
[
723,
24,
1676
]
],
[
[
760,
64,
1478
],
[
1478,
24,
1676
]
],
[
[
760,
25,
351
],
[
351,
... | [
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Grazoprevir"
]
],
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
"Aprepitan... | Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Grazoprevir
Cobicistat may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a... |
DB00607 | DB05239 | 1,249 | 866 | [
"DDInter1256",
"DDInter425"
] | Nafcillin | Cobimetinib | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Major | 2 | [
[
[
1249,
25,
866
]
],
[
[
1249,
24,
214
],
[
214,
63,
866
]
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[
[
1249,
24,
888
],
[
888,
24,
866
]
],
[
[
1249,
25,
484
],
[
484,
... | [
[
[
"Nafcillin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobimetinib"
]
],
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[
"Fostamati... | Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamo... |
DB00014 | DB01242 | 521 | 1,237 | [
"DDInter839",
"DDInter410"
] | Goserelin | Clomipramine | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
521,
24,
1237
]
],
[
[
521,
25,
684
],
[
684,
1,
1237
]
],
[
[
521,
24,
1164
],
[
1164,
1,
1237
]
],
[
[
521,
24,
401
],
[
401,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
"Thiorida... | Goserelin may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (Compound)
Goser... |
DB00773 | DB00987 | 896 | 1,224 | [
"DDInter702",
"DDInter461"
] | Etoposide | Cytarabine (liposomal) | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Cytarabine can cause developmental toxicity according to an independent committee of scientific and health experts. | Moderate | 1 | [
[
[
896,
24,
1224
]
],
[
[
896,
5,
11555
],
[
11555,
44,
1224
]
],
[
[
896,
6,
14544
],
[
14544,
45,
1224
]
],
[
[
896,
7,
7806
],
[
7806,... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cytarabine"
]
],
[
[
"Etoposide",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease)... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine
Etoposide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Cytarabine (Compound)
Etoposide (Compound) binds ABCC10 (Gene) and ABCC10 (Gene) is bound by Cytarabine (Compound)
... |
DB01764 | DB12267 | 805 | 1,476 | [
"DDInter469",
"DDInter233"
] | Dalfopristin | Brigatinib | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
805,
25,
1476
]
],
[
[
805,
25,
1135
],
[
1135,
23,
1476
]
],
[
[
805,
63,
629
],
[
629,
24,
1476
]
],
[
[
805,
24,
951
],
[
951,
... | [
[
[
"Dalfopristin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Dalfopristin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u}... | Dalfopristin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Dalfopristin may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a ... |
DB00696 | DB01234 | 826 | 1,220 | [
"DDInter665",
"DDInter513"
] | Ergotamine | Dexamethasone | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
826,
24,
1220
]
],
[
[
826,
6,
8374
],
[
8374,
45,
1220
]
],
[
[
826,
21,
29106
],
[
29106,
60,
1220
]
],
[
[
826,
25,
22
],
[
22,
... | [
[
[
"Ergotamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Ergotamine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Ergotamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dexamethasone (Compound)
Ergotamine (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Dexamethasone (Compound)
Ergotamine may lead to a major life threatening interaction when taken with Ephedrine and Ephedrine may caus... |
DB00081 | DB05578 | 273 | 330 | [
"DDInter1838",
"DDInter1566"
] | Tositumomab | Ramucirumab | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Major | 2 | [
[
[
273,
25,
330
]
],
[
[
273,
24,
41
],
[
41,
63,
330
]
],
[
[
273,
24,
901
],
[
901,
24,
330
]
],
[
[
273,
25,
1317
],
[
1317,
25,... | [
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ramucirumab"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
[
"Le... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Ramucirumab
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Milnacip... |
DB06589 | DB09082 | 1,250 | 659 | [
"DDInter1400",
"DDInter1934"
] | Pazopanib | Vilanterol | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1250,
24,
659
]
],
[
[
1250,
63,
1220
],
[
1220,
23,
659
]
],
[
[
1250,
64,
1570
],
[
1570,
24,
659
]
],
[
[
1250,
24,
927
],
[
927,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
[
... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Pazopanib may lead to a major life threatening interaction when taken with Azithromycin and Azithromycin may ... |
DB01259 | DB14881 | 392 | 180 | [
"DDInter1024",
"DDInter1329"
] | Lapatinib | Oliceridine | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
392,
24,
180
]
],
[
[
392,
62,
112
],
[
112,
23,
180
]
],
[
[
392,
63,
401
],
[
401,
24,
180
]
],
[
[
392,
24,
124
],
[
124,
24,... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Lapatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Lapatinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Oliceridine
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Pro... |
DB06176 | DB11732 | 1,342 | 1,097 | [
"DDInter1616",
"DDInter1027"
] | Romidepsin | Lasmiditan | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
1342,
24,
1097
]
],
[
[
1342,
63,
1181
],
[
1181,
24,
1097
]
],
[
[
1342,
24,
971
],
[
971,
63,
1097
]
],
[
[
1342,
64,
478
],
[
478,
... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terfenadine"
],
[
... | Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Terfenadine and Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gi... |
DB13997 | DB14491 | 133 | 428 | [
"DDInter163",
"DDInter725"
] | Baloxavir marboxil | Ferrous fumarate | Baloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.[A39895, A251755] It is a prodrug of [baloxavir] with an improved absorption profile than its active metabolite due to the add... | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
133,
24,
428
]
],
[
[
133,
63,
1193
],
[
1193,
23,
428
]
],
[
[
133,
63,
1384
],
[
1384,
24,
428
]
],
[
[
133,
63,
1193
],
[
1193,
... | [
[
[
"Baloxavir marboxil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Baloxavir marboxil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc ... | Baloxavir marboxil may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate
Baloxavir marboxil may cause a moderate interaction that could exacerbate diseases when take... |
DB00959 | DB11730 | 1,486 | 351 | [
"DDInter1191",
"DDInter1588"
] | Methylprednisolone | Ribociclib | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
1486,
24,
351
]
],
[
[
1486,
24,
283
],
[
283,
62,
351
]
],
[
[
1486,
63,
288
],
[
288,
24,
351
]
],
[
[
1486,
24,
987
],
[
987,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Butalbi... |
DB00604 | DB00745 | 1,425 | 307 | [
"DDInter385",
"DDInter1236"
] | Cisapride | Modafinil | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Moderate | 1 | [
[
[
1425,
24,
307
]
],
[
[
1425,
25,
675
],
[
675,
40,
307
]
],
[
[
1425,
64,
847
],
[
847,
40,
307
]
],
[
[
1425,
24,
1335
],
[
1335,
... | [
[
[
"Cisapride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextropropoxyphene"
],
[
"Dextr... | Cisapride may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Modafinil (Compound)
Cisapride may lead to a major life threatening interaction when taken with Atomoxetine and Atomoxetine (Compound) resembles Modafinil (Compound)
Cisapride may ca... |
DB05239 | DB05294 | 866 | 1,069 | [
"DDInter425",
"DDInter1917"
] | Cobimetinib | Vandetanib | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Moderate | 1 | [
[
[
866,
24,
1069
]
],
[
[
866,
64,
362
],
[
362,
24,
1069
]
],
[
[
866,
24,
327
],
[
327,
63,
1069
]
],
[
[
866,
25,
384
],
[
384,
... | [
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vandetanib"
]
],
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenytoin"
],
[
"Phenytoin... | Cobimetinib may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Vandetanib
Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir and Abametapir may cause ... |
DB00682 | DB01284 | 126 | 1,042 | [
"DDInter1951",
"DDInter1782"
] | Warfarin | Tetracosactide | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
126,
24,
1042
]
],
[
[
126,
64,
1023
],
[
1023,
24,
1042
]
],
[
[
126,
24,
1683
],
[
1683,
63,
1042
]
],
[
[
126,
62,
461
],
[
461,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pentobarbital"
],
[
"Pentoba... | Warfarin may lead to a major life threatening interaction when taken with Pentobarbital and Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab ma... |
DB00390 | DB00668 | 1,252 | 874 | [
"DDInter554",
"DDInter652"
] | Digoxin | Epinephrine | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
1252,
24,
874
]
],
[
[
1252,
63,
1636
],
[
1636,
1,
874
]
],
[
[
1252,
24,
688
],
[
688,
63,
874
]
],
[
[
1252,
6,
8374
],
[
8374,
... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
[
... | Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine (Compound) resembles Epinephrine (Compound)
Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that coul... |
DB08930 | DB11126 | 1,459 | 900 | [
"DDInter582",
"DDInter276"
] | Dolutegravir | Calcium gluconate | Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare and ... | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Major | 2 | [
[
[
1459,
25,
900
]
],
[
[
1459,
21,
28698
],
[
28698,
60,
729
],
[
729,
24,
900
]
],
[
[
1459,
64,
1283
],
[
1283,
62,
729
],
[
729,
24... | [
[
[
"Dolutegravir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Dolutegravir",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect) is caused by ... | Dolutegravir (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Penbutolol (Compound) and Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Dolutegravir may lead to a major life threatening interaction when taken with Magnesium oxi... |
DB00501 | DB01209 | 752 | 1,359 | [
"DDInter380",
"DDInter531"
] | Cimetidine | Dezocine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Moderate | 1 | [
[
[
752,
24,
1359
]
],
[
[
752,
24,
234
],
[
234,
1,
1359
]
],
[
[
752,
23,
1438
],
[
1438,
1,
1359
]
],
[
[
752,
24,
1264
],
[
1264,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dezocine"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentazocine"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Pentazocine and Pentazocine (Compound) resembles Dezocine (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Estradiol and Estradiol (Compound) resembles Dezocine (Compound)
Cimeti... |
DB00816 | DB01211 | 1,674 | 609 | [
"DDInter1346",
"DDInter393"
] | Orciprenaline | Clarithromycin | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1674,
24,
609
]
],
[
[
1674,
63,
1570
],
[
1570,
24,
609
]
],
[
[
1674,
21,
28662
],
[
28662,
60,
609
]
],
[
[
1674,
63,
600
],
[
600,... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Orciprenaline (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Clarithrom... |
DB01064 | DB06694 | 1,148 | 31 | [
"DDInter987",
"DDInter1952"
] | Isoprenaline | Xylometazoline (nasal) | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Xylometazoline is an alkylbenzene. | Moderate | 1 | [
[
[
1148,
24,
31
]
],
[
[
1148,
63,
87
],
[
87,
24,
31
]
],
[
[
1148,
24,
144
],
[
144,
63,
31
]
],
[
[
1148,
24,
1237
],
[
1237,
24... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Xylometazoline"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amoxapine"
],
... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline
... |
DB00242 | DB12001 | 1,064 | 564 | [
"DDInter392",
"DDInter7"
] | Cladribine | Abemaciclib | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Major | 2 | [
[
[
1064,
25,
564
]
],
[
[
1064,
24,
748
],
[
748,
24,
564
]
],
[
[
1064,
64,
58
],
[
58,
24,
564
]
],
[
[
1064,
24,
1017
],
[
1017,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abemaciclib"
]
],
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
[
"Anth... | Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Cladribine may lead to a major life threatening interaction when taken with Alefacept and Alefacept m... |
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