drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01242 | DB01409 | 1,237 | 1,415 | [
"DDInter410",
"DDInter1815"
] | Clomipramine | Tiotropium | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
1237,
24,
1415
]
],
[
[
1237,
6,
8374
],
[
8374,
45,
1415
]
],
[
[
1237,
21,
29187
],
[
29187,
60,
1415
]
],
[
[
1237,
63,
752
],
[
75... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Clomipramine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Clomipramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tiotropium (Compound)
Clomipramine (Compound) causes Rhinitis (Side Effect) and Rhinitis (Side Effect) is caused by Tiotropium (Compound)
Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and ... |
DB00218 | DB00290 | 1,176 | 329 | [
"DDInter1247",
"DDInter219"
] | Moxifloxacin | Bleomycin | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Minor | 0 | [
[
[
1176,
23,
329
]
],
[
[
1176,
21,
28769
],
[
28769,
60,
329
]
],
[
[
1176,
1,
246
],
[
246,
62,
329
]
],
[
[
1176,
24,
372
],
[
372,
... | [
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bleomycin"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Feeling abnormal"
],
[
"Feeling abnormal",
"{u} (Side ... | Moxifloxacin (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Bleomycin (Compound)
Moxifloxacin (Compound) resembles Gatifloxacin (Compound) and Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Bleomycin
Moxifloxacin may cause a m... |
DB00757 | DB04868 | 1,166 | 478 | [
"DDInter581",
"DDInter1293"
] | Dolasetron | Nilotinib | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1166,
25,
478
]
],
[
[
1166,
6,
6017
],
[
6017,
45,
478
]
],
[
[
1166,
21,
28963
],
[
28963,
60,
478
]
],
[
[
1166,
23,
1247
],
[
1247... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Dolasetron",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Nilotini... | Dolasetron (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Dolasetron (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Nilotinib (Compound)
Dolasetron may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfam... |
DB00845 | DB06589 | 1,490 | 1,250 | [
"DDInter406",
"DDInter1400"
] | Clofazimine | Pazopanib | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1490,
24,
1250
]
],
[
[
1490,
6,
4973
],
[
4973,
45,
1250
]
],
[
[
1490,
21,
28658
],
[
28658,
60,
1250
]
],
[
[
1490,
23,
112
],
[
11... | [
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Clofazimine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Clofazimine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Pazopanib (Compound)
Clofazimine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Pazopanib (Compound)
Clofazimine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metron... |
DB00372 | DB09481 | 999 | 460 | [
"DDInter1793",
"DDInter1113"
] | Thiethylperazine | Magnesium carbonate | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
999,
23,
460
]
],
[
[
999,
24,
664
],
[
664,
23,
460
]
],
[
[
999,
63,
556
],
[
556,
23,
460
]
],
[
[
999,
25,
684
],
[
684,
23,... | [
[
[
"Thiethylperazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perindop... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Perindopril and Perindopril may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00352 | DB00744 | 482 | 1,288 | [
"DDInter1814",
"DDInter1962"
] | Tioguanine | Zileuton | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, a... | Moderate | 1 | [
[
[
482,
24,
1288
]
],
[
[
482,
21,
28826
],
[
28826,
60,
1288
]
],
[
[
482,
63,
305
],
[
305,
24,
1288
]
],
[
[
482,
24,
187
],
[
187,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zileuton"
]
],
[
[
"Tioguanine",
"{u} (Compound) causes {v} (Side Effect)",
"Jaundice"
],
[
"Jaundice",
"{u} (Side Effect) is caused b... | Tioguanine (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Zileuton (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbat... |
DB00682 | DB14357 | 126 | 944 | [
"DDInter1951",
"DDInter347"
] | Warfarin | Chamomile | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
126,
23,
944
]
],
[
[
126,
25,
256
],
[
256,
23,
944
]
],
[
[
126,
64,
582
],
[
582,
23,
944
]
],
[
[
126,
63,
1061
],
[
1061,
2... | [
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel",
... | Warfarin may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Warfarin may lead to a major life threatening interaction when taken with Reteplase and Reteplase may cause a minor interaction that c... |
DB00186 | DB01075 | 905 | 1,376 | [
"DDInter1092",
"DDInter569"
] | Lorazepam | Diphenhydramine | Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
905,
24,
1376
]
],
[
[
905,
24,
649
],
[
649,
63,
1376
]
],
[
[
905,
24,
128
],
[
128,
24,
1376
]
],
[
[
905,
21,
28921
],
[
28921,
... | [
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[... | Lorazepam may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Lorazepam may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine... |
DB08880 | DB12001 | 1,510 | 564 | [
"DDInter1771",
"DDInter7"
] | Teriflunomide | Abemaciclib | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Major | 2 | [
[
[
1510,
25,
564
]
],
[
[
1510,
25,
868
],
[
868,
24,
564
]
],
[
[
1510,
24,
748
],
[
748,
24,
564
]
],
[
[
1510,
64,
58
],
[
58,
2... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abemaciclib"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
],
[
"Vemurafenib",
... | Teriflunomide may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax... |
DB00087 | DB00361 | 599 | 134 | [
"DDInter41",
"DDInter1939"
] | Alemtuzumab | Vinorelbine | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction of third... | Moderate | 1 | [
[
[
599,
24,
134
]
],
[
[
599,
24,
147
],
[
147,
63,
134
]
],
[
[
599,
24,
1101
],
[
1101,
24,
134
]
],
[
[
599,
63,
1451
],
[
1451,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and B... |
DB00204 | DB11113 | 228 | 657 | [
"DDInter580",
"DDInter307"
] | Dofetilide | Castor oil | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
228,
24,
657
]
],
[
[
228,
25,
927
],
[
927,
63,
657
]
],
[
[
228,
40,
540
],
[
540,
24,
657
]
],
[
[
228,
25,
1491
],
[
1491,
2... | [
[
[
"Dofetilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encorafen... | Dofetilide may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Dofetilide (Compound) resembles Dronedarone (Compound) and Dronedarone may cause a moderate interaction that could exacerbate... |
DB00373 | DB00912 | 461 | 473 | [
"DDInter1809",
"DDInter1581"
] | Timolol | Repaglinide | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
461,
24,
473
]
],
[
[
461,
21,
28763
],
[
28763,
60,
473
]
],
[
[
461,
24,
1148
],
[
1148,
63,
473
]
],
[
[
461,
24,
1512
],
[
1512,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Timolol",
"{u} (Compound) causes {v} (Side Effect)",
"Chest pain"
],
[
"Chest pain",
"{u} (Side Effect) is caused ... | Timolol (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Repaglinide (Compound)
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Repagl... |
DB01244 | DB06791 | 762 | 1,446 | [
"DDInter192",
"DDInter1021"
] | Bepridil | Lanreotide | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Moderate | 1 | [
[
[
762,
24,
1446
]
],
[
[
762,
24,
159
],
[
159,
63,
1446
]
],
[
[
762,
24,
549
],
[
549,
24,
1446
]
],
[
[
762,
25,
971
],
[
971,
... | [
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanreotide"
]
],
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide
Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and D... |
DB01394 | DB12834 | 1,554 | 148 | [
"DDInter431",
"DDInter1649"
] | Colchicine | Secnidazole | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
1554,
24,
148
]
],
[
[
1554,
25,
1593
],
[
1593,
24,
148
]
],
[
[
1554,
24,
1480
],
[
1480,
24,
148
]
],
[
[
1554,
63,
597
],
[
597,
... | [
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Colchicine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Crizotini... | Colchicine may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib may cause a m... |
DB00047 | DB13620 | 176 | 948 | [
"DDInter932",
"DDInter1499"
] | Insulin glargine | Potassium gluconate | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Potassium gluconate is a salt of and is classified as a food additive by the FDA . It is also used as a potassium supplement . Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function . In dietary supplements, potassium is ofte... | Minor | 0 | [
[
[
176,
23,
948
]
],
[
[
176,
24,
914
],
[
914,
24,
948
]
],
[
[
176,
24,
1414
],
[
1414,
25,
948
]
],
[
[
176,
24,
914
],
[
914,
2... | [
[
[
"Insulin glargine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Potassium gluconate"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diflunis... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal and Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Potassium gluconate
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00060 | DB06718 | 912 | 1,687 | [
"DDInter947",
"DDInter1709"
] | Interferon beta-1a | Stanozolol | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Moderate | 1 | [
[
[
912,
24,
1687
]
],
[
[
912,
24,
1546
],
[
1546,
1,
1687
]
],
[
[
912,
24,
1561
],
[
1561,
40,
1687
]
],
[
[
912,
24,
384
],
[
384,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stanozolol"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltesto... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Stanozolol (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testosterone (Compou... |
DB00736 | DB06626 | 660 | 263 | [
"DDInter676",
"DDInter147"
] | Esomeprazole | Axitinib | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Minor | 0 | [
[
[
660,
23,
263
]
],
[
[
660,
1,
1215
],
[
1215,
23,
263
]
],
[
[
660,
40,
837
],
[
837,
23,
263
]
],
[
[
660,
24,
1335
],
[
1335,
... | [
[
[
"Esomeprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Axitinib"
]
],
[
[
"Esomeprazole",
"{u} (Compound) resembles {v} (Compound)",
"Lansoprazole"
],
[
"Lansoprazole",
"{u} may cause a min... | Esomeprazole (Compound) resembles Lansoprazole (Compound) and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Axitinib
Esomeprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole may cause a minor interaction that can limit clinical effects when taken with Axiti... |
DB09039 | DB09118 | 1,670 | 1,580 | [
"DDInter629",
"DDInter1711"
] | Eliglustat | Stiripentol | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Major | 2 | [
[
[
1670,
25,
1580
]
],
[
[
1670,
63,
1409
],
[
1409,
24,
1580
]
],
[
[
1670,
25,
283
],
[
283,
63,
1580
]
],
[
[
1670,
24,
98
],
[
98,
... | [
[
[
"Eliglustat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Stiripentol"
]
],
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
],
[
"Apixaban",
... | Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Eliglustat may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a m... |
DB00277 | DB04854 | 1,031 | 1,291 | [
"DDInter1791",
"DDInter713"
] | Theophylline | Febuxostat | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout. In the following year, the FDA for approved febuxostat for use in the chronic management of hyperuricemia in adult pat... | Moderate | 1 | [
[
[
1031,
24,
1291
]
],
[
[
1031,
1,
746
],
[
746,
24,
1291
]
],
[
[
1031,
24,
663
],
[
663,
24,
1291
]
],
[
[
1031,
24,
1613
],
[
1613,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Febuxostat"
]
],
[
[
"Theophylline",
"{u} (Compound) resembles {v} (Compound)",
"Dyphylline"
],
[
"Dyphylline",
"{u} may cause a mod... | Theophylline (Compound) resembles Dyphylline (Compound) and Dyphylline may cause a moderate interaction that could exacerbate diseases when taken with Febuxostat
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction th... |
DB00191 | DB01381 | 73 | 958 | [
"DDInter1447",
"DDInter819"
] | Phentermine | Ginkgo biloba | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
73,
24,
958
]
],
[
[
73,
25,
121
],
[
121,
24,
958
]
],
[
[
73,
24,
401
],
[
401,
24,
958
]
],
[
[
73,
35,
22
],
[
22,
24,
... | [
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Phentermine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fenfluramine"
],
[
"Fen... | Phentermine may lead to a major life threatening interaction when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazi... |
DB00414 | DB01404 | 590 | 757 | [
"DDInter16",
"DDInter820"
] | Acetohexamide | Ginseng | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Moderate | 1 | [
[
[
590,
24,
757
]
],
[
[
590,
24,
170
],
[
170,
24,
757
]
],
[
[
590,
24,
1344
],
[
1344,
63,
757
]
],
[
[
590,
63,
1179
],
[
1179,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginseng"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Ginseng
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin an... |
DB00078 | DB00465 | 1,172 | 886 | [
"DDInter898",
"DDInter1010"
] | Ibritumomab tiuxetan | Ketorolac | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Major | 2 | [
[
[
1172,
37,
886
]
],
[
[
1172,
24,
282
],
[
282,
40,
886
]
],
[
[
1172,
25,
24
],
[
24,
40,
886
]
],
[
[
1172,
64,
25
],
[
25,
24,... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Ketorolac"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate int... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and
Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Nepafenac and Nepafenac (Compound) resembles Ketorolac (Compound)
Ibritumomab tiuxetan may lead to a maj... |
DB00814 | DB00912 | 1,171 | 473 | [
"DDInter1143",
"DDInter1581"
] | Meloxicam | Repaglinide | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
1171,
24,
473
]
],
[
[
1171,
6,
3486
],
[
3486,
45,
473
]
],
[
[
1171,
21,
28873
],
[
28873,
60,
473
]
],
[
[
1171,
63,
1512
],
[
1512... | [
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Meloxicam",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Meloxicam (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Repaglinide (Compound)
Meloxicam (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Repaglinide (Compound)
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and... |
DB01268 | DB11932 | 1,151 | 327 | [
"DDInter1731",
"DDInter3"
] | Sunitinib | Abametapir (topical) | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
1151,
24,
327
]
],
[
[
1151,
24,
124
],
[
124,
63,
327
]
],
[
[
1151,
63,
79
],
[
79,
24,
327
]
],
[
[
1151,
25,
1069
],
[
1069,
... | [
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
],
[
... | Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Sunitinib may ... |
DB01211 | DB14840 | 609 | 861 | [
"DDInter393",
"DDInter1601"
] | Clarithromycin | Ripretinib | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Major | 2 | [
[
[
609,
25,
861
]
],
[
[
609,
25,
351
],
[
351,
24,
861
]
],
[
[
609,
63,
918
],
[
918,
24,
861
]
],
[
[
609,
24,
973
],
[
973,
24,... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ripretinib"
]
],
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Ribociclib",
... | Clarithromycin may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamid... |
DB00054 | DB06779 | 1,432 | 365 | [
"DDInter6",
"DDInter470"
] | Abciximab | Dalteparin | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
1432,
25,
365
]
],
[
[
1432,
23,
539
],
[
539,
62,
365
]
],
[
[
1432,
24,
1496
],
[
1496,
63,
365
]
],
[
[
1432,
24,
1100
],
[
1100,
... | [
[
[
"Abciximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Abciximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Abciximab may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Dalteparin
Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nintedanib may c... |
DB00261 | DB01611 | 702 | 1,487 | [
"DDInter93",
"DDInter893"
] | Anagrelide | Hydroxychloroquine | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
702,
25,
1487
]
],
[
[
702,
25,
1520
],
[
1520,
25,
1487
]
],
[
[
702,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
702,
23,
1247
],
[
1247... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
],
[
"Primaquine",
... | Anagrelide may lead to a major life threatening interaction when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Anagrelide (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Anagrelide m... |
DB06791 | DB15822 | 1,446 | 69 | [
"DDInter1021",
"DDInter1504"
] | Lanreotide | Pralsetinib | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small... | Moderate | 1 | [
[
[
1446,
24,
69
]
],
[
[
1446,
24,
124
],
[
124,
24,
69
]
],
[
[
1446,
24,
124
],
[
124,
24,
283
],
[
283,
24,
69
]
],
[
[
1446,
24... | [
[
[
"Lanreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pralsetinib"
]
],
[
[
"Lanreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
],
[
... | Lanreotide may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Pralsetinib
Lanreotide may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegi... |
DB04938 | DB06292 | 1,423 | 549 | [
"DDInter1353",
"DDInter474"
] | Ospemifene | Dapagliflozin | Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1423,
24,
549
]
],
[
[
1423,
6,
8374
],
[
8374,
45,
549
]
],
[
[
1423,
21,
28936
],
[
28936,
60,
549
]
],
[
[
1423,
63,
79
],
[
79,
... | [
[
[
"Ospemifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Ospemifene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Ospemifene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Ospemifene (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Dapagliflozin (Compound)
Ospemifene may cause a moderate interaction that could exacerbate diseases when taken with Soraf... |
DB00726 | DB01619 | 1,164 | 830 | [
"DDInter1876",
"DDInter1441"
] | Trimipramine | Phenindamine | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1164,
24,
830
]
],
[
[
1164,
24,
537
],
[
537,
40,
830
]
],
[
[
1164,
1,
114
],
[
114,
1,
830
]
],
[
[
1164,
63,
1219
],
[
1219,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
... | Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Trimipramine (Compound) resembles Nortriptyline (Compound) and Nortriptyline (Compound) resembles Phenindamine (Compound)
Trimipramine may cause a moderate in... |
DB08816 | DB14881 | 578 | 180 | [
"DDInter1802",
"DDInter1329"
] | Ticagrelor | Oliceridine | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
578,
24,
180
]
],
[
[
578,
24,
1094
],
[
1094,
24,
180
]
],
[
[
578,
63,
1039
],
[
1039,
24,
180
]
],
[
[
578,
64,
1213
],
[
1213,
... | [
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
],
[
... | Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin and Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine an... |
DB00046 | DB00595 | 1,179 | 1,545 | [
"DDInter940",
"DDInter1374"
] | Insulin lispro | Oxytetracycline | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Moderate | 1 | [
[
[
1179,
24,
1545
]
],
[
[
1179,
24,
964
],
[
964,
1,
1545
]
],
[
[
1179,
24,
471
],
[
471,
62,
1545
]
],
[
[
1179,
24,
1028
],
[
1028,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxytetracycline"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxycycline"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline (Compound) resembles Oxytetracycline (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Acetazolamide and Acetazolamide may cause a minor inte... |
DB00308 | DB00581 | 347 | 355 | [
"DDInter901",
"DDInter1018"
] | Ibutilide | Lactulose | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Moderate | 1 | [
[
[
347,
24,
355
]
],
[
[
347,
21,
28722
],
[
28722,
60,
355
]
],
[
[
347,
24,
286
],
[
286,
62,
355
]
],
[
[
347,
25,
79
],
[
79,
2... | [
[
[
"Ibutilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
]
],
[
[
"Ibutilide",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v}... | Ibutilide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lactulose (Compound)
Ibutilide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with ... |
DB00215 | DB00278 | 1,230 | 291 | [
"DDInter388",
"DDInter117"
] | Citalopram | Argatroban | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Moderate | 1 | [
[
[
1230,
24,
291
]
],
[
[
1230,
6,
8374
],
[
8374,
45,
291
]
],
[
[
1230,
21,
28931
],
[
28931,
60,
291
]
],
[
[
1230,
25,
121
],
[
121,
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Argatroban"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Citalopram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Argatroban (Compound)
Citalopram (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Argatroban (Compound)
Citalopram may lead to a major life threatening interaction when taken with Fenfluramine and Fenfluramine ... |
DB00708 | DB00902 | 1,454 | 104 | [
"DDInter1718",
"DDInter1168"
] | Sufentanil | Methdilazine | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
1454,
24,
104
]
],
[
[
1454,
63,
13
],
[
13,
24,
104
]
],
[
[
1454,
24,
820
],
[
820,
1,
104
]
],
[
[
1454,
24,
537
],
[
537,
40... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine... |
DB11627 | DB11760 | 1,367 | 119 | [
"DDInter860",
"DDInter1742"
] | Hepatitis B Vaccine (Recombinant) | Talazoparib | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
1367,
24,
119
]
],
[
[
1367,
63,
66
],
[
66,
24,
119
]
],
[
[
1367,
24,
351
],
[
351,
24,
119
]
],
[
[
1367,
24,
1619
],
[
1619,
... | [
[
[
"Hepatitis B Vaccine (Recombinant)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Hepatitis B Vaccine (Recombinant)",
"{u} may cause a moderate interaction that could exacerbate diseases when take... | Hepatitis B Vaccine (Recombinant) may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Hepatitis B Vaccine (Recombinant) may cause a moderate interaction that could exacerbate... |
DB00342 | DB00363 | 1,181 | 695 | [
"DDInter1770",
"DDInter419"
] | Terfenadine | Clozapine | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Major | 2 | [
[
[
1181,
25,
695
]
],
[
[
1181,
24,
1178
],
[
1178,
1,
695
]
],
[
[
1181,
24,
623
],
[
623,
40,
695
]
],
[
[
1181,
63,
867
],
[
867,
... | [
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
],
[
"Trif... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Clozapine (Compound)
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Clozapine (... |
DB01577 | DB06704 | 1,529 | 247 | [
"DDInter1161",
"DDInter951"
] | Metamfetamine | Iobenguane (I-123) | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
1529,
37,
247
]
],
[
[
1529,
6,
7390
],
[
7390,
45,
247
]
],
[
[
1529,
21,
28921
],
[
28921,
60,
247
]
],
[
[
1529,
63,
820
],
[
820,
... | [
[
[
"Metamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Metamfetamine",
"{u} (Compound) binds {v} (Gene)",
"... | Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Metamfetamine may lead to a major life threatening interaction when taken with Iobenguane
Metamfetamine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Metamfetamine (Compound)... |
DB01060 | DB09268 | 319 | 1,662 | [
"DDInter83",
"DDInter1464"
] | Amoxicillin | Picosulfuric acid | Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin. Amoxicillin was granted FDA approval on 18 January 1974. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
319,
24,
1662
]
],
[
[
319,
23,
68
],
[
68,
63,
1662
]
],
[
[
319,
40,
916
],
[
916,
24,
1662
]
],
[
[
319,
63,
964
],
[
964,
24... | [
[
[
"Amoxicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Amoxicillin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Troleandomycin"
... | Amoxicillin may cause a minor interaction that can limit clinical effects when taken with Troleandomycin and Troleandomycin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Amoxicillin (Compound) resembles Dicloxacillin (Compound) and Dicloxacillin may cause a moderate i... |
DB01309 | DB06343 | 1,254 | 1,379 | [
"DDInter933",
"DDInter1766"
] | Insulin glulisine | Teprotumumab | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Teprotumumab is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor. Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016 and was approved by th... | Moderate | 1 | [
[
[
1254,
24,
1379
]
],
[
[
1254,
63,
959
],
[
959,
24,
1379
]
],
[
[
1254,
24,
1450
],
[
1450,
63,
1379
]
],
[
[
1254,
24,
1002
],
[
1002... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teprotumumab"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Teprotumumab
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Empagli... |
DB00662 | DB00802 | 717 | 1,322 | [
"DDInter1873",
"DDInter43"
] | Trimethobenzamide | Alfentanil | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Moderate | 1 | [
[
[
717,
24,
1322
]
],
[
[
717,
24,
411
],
[
411,
1,
1322
]
],
[
[
717,
21,
28766
],
[
28766,
60,
1322
]
],
[
[
717,
24,
1219
],
[
1219,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alfentanil"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remifentanil"... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Remifentanil and Remifentanil (Compound) resembles Alfentanil (Compound)
Trimethobenzamide (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Alfentanil (Compound)
Trimethobenzamide may ... |
DB01206 | DB06372 | 37 | 259 | [
"DDInter1086",
"DDInter1594"
] | Lomustine | Rilonacept | An alkylating agent of value against both hematologic malignancies and solid tumors. | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
37,
24,
259
]
],
[
[
37,
63,
1461
],
[
1461,
23,
259
]
],
[
[
37,
63,
0
],
[
0,
24,
259
]
],
[
[
37,
24,
1330
],
[
1330,
63,
... | [
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Dactinomycin and Dactinomyc... |
DB00790 | DB08894 | 664 | 1,126 | [
"DDInter1431",
"DDInter1406"
] | Perindopril | Peginesatide | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of th... | Minor | 0 | [
[
[
664,
23,
1126
]
],
[
[
664,
40,
610
],
[
610,
23,
1126
]
],
[
[
664,
1,
954
],
[
954,
23,
1126
]
],
[
[
664,
40,
610
],
[
610,
1... | [
[
[
"Perindopril",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Peginesatide"
]
],
[
[
"Perindopril",
"{u} (Compound) resembles {v} (Compound)",
"Enalapril"
],
[
"Enalapril",
"{u} may cause a minor i... | Perindopril (Compound) resembles Enalapril (Compound) and Enalapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Perindopril (Compound) resembles Quinapril (Compound) and Quinapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Pe... |
DB00350 | DB00470 | 1,214 | 530 | [
"DDInter1226",
"DDInter601"
] | Minoxidil | Dronabinol | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
1214,
24,
530
]
],
[
[
1214,
24,
1614
],
[
1614,
40,
530
]
],
[
[
1214,
6,
10522
],
[
10522,
45,
530
]
],
[
[
1214,
24,
358
],
[
358,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Minoxidil (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Dronabinol (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases ... |
DB01001 | DB06788 | 688 | 1,616 | [
"DDInter1632",
"DDInter864"
] | Salbutamol | Histrelin | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
688,
24,
1616
]
],
[
[
688,
62,
112
],
[
112,
23,
1616
]
],
[
[
688,
23,
1247
],
[
1247,
23,
1616
]
],
[
[
688,
63,
1664
],
[
1664,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Salbutamol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Salbutamol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Salbutamol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and S... |
DB00603 | DB04908 | 303 | 1,671 | [
"DDInter1137",
"DDInter741"
] | Medroxyprogesterone acetate | Flibanserin | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
303,
24,
1671
]
],
[
[
303,
24,
98
],
[
98,
63,
1671
]
],
[
[
303,
63,
1051
],
[
1051,
24,
1671
]
],
[
[
303,
24,
478
],
[
478,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when t... |
DB00414 | DB00647 | 590 | 675 | [
"DDInter16",
"DDInter528"
] | Acetohexamide | Dextropropoxyphene | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Moderate | 1 | [
[
[
590,
24,
675
]
],
[
[
590,
63,
494
],
[
494,
1,
675
]
],
[
[
590,
24,
1164
],
[
1164,
1,
675
]
],
[
[
590,
24,
954
],
[
954,
40,... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Dextropropoxyphene (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles ... |
DB00196 | DB00959 | 600 | 1,486 | [
"DDInter743",
"DDInter1191"
] | Fluconazole | Methylprednisolone | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
600,
24,
1486
]
],
[
[
600,
24,
175
],
[
175,
40,
1486
]
],
[
[
600,
24,
167
],
[
167,
1,
1486
]
],
[
[
600,
6,
8374
],
[
8374,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resemble... |
DB00401 | DB06663 | 84 | 1,154 | [
"DDInter1298",
"DDInter1398"
] | Nisoldipine | Pasireotide | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Moderate | 1 | [
[
[
84,
24,
1154
]
],
[
[
84,
63,
966
],
[
966,
40,
1154
]
],
[
[
84,
21,
29013
],
[
29013,
60,
1154
]
],
[
[
84,
1,
409
],
[
409,
2... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
]
],
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
[... | Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Nisoldipine (Compound) causes Diabetes mellitus (Side Effect) and Diabetes mellitus (Side Effect) is caused by Pasireotide (Compound)
Nisoldipine (Compound) r... |
DB00773 | DB10276 | 896 | 1,624 | [
"DDInter702",
"DDInter1623"
] | Etoposide | Rotavirus vaccine | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
896,
25,
1624
]
],
[
[
896,
63,
552
],
[
552,
25,
1624
]
],
[
[
896,
24,
1307
],
[
1307,
25,
1624
]
],
[
[
896,
25,
770
],
[
770,
... | [
[
[
"Etoposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
],
[
"Carmu... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Carmustine may lead to a major life threatening interaction when taken with Rotavirus vaccine
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan may lea... |
DB00384 | DB09133 | 1,275 | 1,527 | [
"DDInter1859",
"DDInter965"
] | Triamterene | Iothalamic acid | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Moderate | 1 | [
[
[
1275,
24,
1527
]
],
[
[
1275,
63,
1648
],
[
1648,
24,
1527
]
],
[
[
1275,
24,
1512
],
[
1512,
25,
1527
]
],
[
[
1275,
63,
1645
],
[
16... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
... | Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac a... |
DB00515 | DB08895 | 589 | 976 | [
"DDInter387",
"DDInter1825"
] | Cisplatin | Tofacitinib | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
589,
25,
976
]
],
[
[
589,
63,
1461
],
[
1461,
23,
976
]
],
[
[
589,
24,
660
],
[
660,
24,
976
]
],
[
[
589,
24,
200
],
[
200,
6... | [
[
[
"Cisplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomepraz... |
DB06273 | DB12674 | 980 | 975 | [
"DDInter1824",
"DDInter1105"
] | Tocilizumab | Lurbinectedin | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
980,
24,
975
]
],
[
[
980,
63,
1488
],
[
1488,
24,
975
]
],
[
[
980,
24,
1613
],
[
1613,
24,
975
]
],
[
[
980,
64,
1531
],
[
1531,
... | [
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
... | Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon ... |
DB01193 | DB11348 | 819 | 1,065 | [
"DDInter12",
"DDInter279"
] | Acebutolol | Calcium Phosphate | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] . | Moderate | 1 | [
[
[
819,
24,
1065
]
],
[
[
819,
40,
1121
],
[
1121,
24,
1065
]
],
[
[
819,
62,
1152
],
[
1152,
24,
1065
]
],
[
[
819,
40,
1121
],
[
1121,
... | [
[
[
"Acebutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium Phosphate"
]
],
[
[
"Acebutolol",
"{u} (Compound) resembles {v} (Compound)",
"Bisoprolol"
],
[
"Bisoprolol",
"{u} may cause a ... | Acebutolol (Compound) resembles Bisoprolol (Compound) and Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium Phosphate
Acebutolol may cause a minor interaction that can limit clinical effects when taken with Liothyronine and Liothyronine may cause a moderate interaction t... |
DB00543 | DB00907 | 87 | 290 | [
"DDInter82",
"DDInter427"
] | Amoxapine | Cocaine (topical) | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Major | 2 | [
[
[
87,
25,
290
]
],
[
[
87,
24,
85
],
[
85,
1,
290
]
],
[
[
87,
63,
19
],
[
19,
1,
290
]
],
[
[
87,
6,
2437
],
[
2437,
45,
29... | [
[
[
"Amoxapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cocaine"
]
],
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
],
[
"Atropine",
... | Amoxapine may lead to a major life threatening interaction when taken with Cocaine
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Cocaine (Compound)
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00374 | DB04835 | 1,061 | 1,655 | [
"DDInter1852",
"DDInter1125"
] | Treprostinil | Maraviroc | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Moderate | 1 | [
[
[
1061,
24,
1655
]
],
[
[
1061,
21,
28921
],
[
28921,
60,
1655
]
],
[
[
1061,
63,
1214
],
[
1214,
24,
1655
]
],
[
[
1061,
25,
1468
],
[
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maraviroc"
]
],
[
[
"Treprostinil",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is c... | Treprostinil (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Maraviroc (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Minoxidil and Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Maravi... |
DB00624 | DB11901 | 1,561 | 913 | [
"DDInter1775",
"DDInter107"
] | Testosterone | Apalutamide | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1561,
24,
913
]
],
[
[
1561,
40,
312
],
[
312,
23,
913
]
],
[
[
1561,
63,
600
],
[
600,
24,
913
]
],
[
[
1561,
40,
303
],
[
303,
... | [
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Testosterone",
"{u} (Compound) resembles {v} (Compound)",
"Eplerenone"
],
[
"Eplerenone",
"{u} may cause a mi... | Testosterone (Compound) resembles Eplerenone (Compound) and Eplerenone may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that ... |
DB00626 | DB01226 | 1,441 | 1,319 | [
"DDInter161",
"DDInter1235"
] | Bacitracin | Mivacurium | Bacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Bacitracin was granted FDA approval on 29 July 1948.[A... | Mivacurium is a bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant. It binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission. | Moderate | 1 | [
[
[
1441,
24,
1319
]
],
[
[
1441,
24,
648
],
[
648,
1,
1319
]
],
[
[
1441,
21,
28680
],
[
28680,
60,
1319
]
],
[
[
1441,
63,
91
],
[
91,
... | [
[
[
"Bacitracin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mivacurium"
]
],
[
[
"Bacitracin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxacurium"
],
[
... | Bacitracin may cause a moderate interaction that could exacerbate diseases when taken with Doxacurium and Doxacurium (Compound) resembles Mivacurium (Compound)
Bacitracin (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Mivacurium (Compound)
Bacitracin may cause a moderate interaction that could... |
DB00294 | DB09564 | 1,336 | 1,296 | [
"DDInter701",
"DDInter930"
] | Etonogestrel | Insulin degludec | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1336,
24,
1296
]
],
[
[
1336,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
1336,
24,
1385
],
[
1385,
63,
1296
]
],
[
[
1336,
40,
1197
],
[
11... | [
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
... | Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with Semagluti... |
DB00775 | DB00939 | 1,226 | 1,338 | [
"DDInter1818",
"DDInter1135"
] | Tirofiban | Meclofenamic acid | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Moderate | 1 | [
[
[
1226,
24,
1338
]
],
[
[
1226,
24,
1479
],
[
1479,
63,
1338
]
],
[
[
1226,
21,
29232
],
[
29232,
60,
1338
]
],
[
[
1226,
64,
1347
],
[
... | [
[
[
"Tirofiban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid"
]
],
[
[
"Tirofiban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
... | Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid
Tirofiban (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is cau... |
DB00902 | DB11859 | 104 | 418 | [
"DDInter1168",
"DDInter230"
] | Methdilazine | Brexanolone | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | As of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as the brand name product Zulresso - is the first drug to have ever been approved by the US FDA specifically for the treatment of postpartum depression (PPD) in adult females . Since PPD, like various other types of depr... | Moderate | 1 | [
[
[
104,
24,
418
]
],
[
[
104,
40,
820
],
[
820,
24,
418
]
],
[
[
104,
63,
100
],
[
100,
24,
418
]
],
[
[
104,
24,
407
],
[
407,
24,... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexanolone"
]
],
[
[
"Methdilazine",
"{u} (Compound) resembles {v} (Compound)",
"Alimemazine"
],
[
"Alimemazine",
"{u} may cause a ... | Methdilazine (Compound) resembles Alimemazine (Compound) and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Brexanolone
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate inter... |
DB00490 | DB01110 | 946 | 86 | [
"DDInter254",
"DDInter1209"
] | Buspirone | Miconazole | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
946,
24,
86
]
],
[
[
946,
6,
4973
],
[
4973,
45,
86
]
],
[
[
946,
21,
29081
],
[
29081,
60,
86
]
],
[
[
946,
25,
222
],
[
222,
2... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Buspirone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Buspirone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Miconazole (Compound)
Buspirone (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Miconazole (Compound)
Buspirone may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause... |
DB01181 | DB06151 | 1,532 | 531 | [
"DDInter906",
"DDInter19"
] | Ifosfamide | Acetylcysteine | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of [acetaminophen] overdose.[L31378,L31383,L31388,L31478] Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.[A228158,A228163,A228168] Acetylcysteine was granted FD... | Minor | 0 | [
[
[
1532,
23,
531
]
],
[
[
1532,
7,
5415
],
[
5415,
46,
531
]
],
[
[
1532,
21,
28645
],
[
28645,
60,
531
]
],
[
[
1532,
7,
5415
],
[
5415,... | [
[
[
"Ifosfamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetylcysteine"
]
],
[
[
"Ifosfamide",
"{u} (Compound) upregulates {v} (Gene)",
"UBQLN2"
],
[
"UBQLN2",
"{u} (Gene) is upregulated by {v... | Ifosfamide (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Acetylcysteine (Compound)
Ifosfamide (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Acetylcysteine (Compound)
Ifosfamide (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is regulated by CDK6 (Gene) and ... |
DB00213 | DB13257 | 837 | 260 | [
"DDInter1388",
"DDInter727"
] | Pantoprazole | Ferrous sulfate anhydrous | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age. This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation of erythrocytes, also known as red blood cells. Ferrous sulfate is a sy... | Moderate | 1 | [
[
[
837,
24,
260
]
],
[
[
837,
24,
542
],
[
542,
24,
260
]
],
[
[
837,
1,
1215
],
[
1215,
24,
260
]
],
[
[
837,
24,
542
],
[
542,
23... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous sulfate anhydrous"
]
],
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyr... | Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Ferrous sulfate anhydrous
Pantoprazole (Compound) resembles Lansoprazole (Compound) and Lansoprazole may cause a mo... |
DB00915 | DB01075 | 1,170 | 1,376 | [
"DDInter60",
"DDInter569"
] | Amantadine | Diphenhydramine | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesi... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
1170,
24,
1376
]
],
[
[
1170,
63,
128
],
[
128,
24,
1376
]
],
[
[
1170,
24,
401
],
[
401,
24,
1376
]
],
[
[
1170,
6,
8803
],
[
8803,
... | [
[
[
"Amantadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Amantadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
... | Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Amantadine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00570 | DB15091 | 147 | 676 | [
"DDInter1936",
"DDInter1901"
] | Vinblastine | Upadacitinib | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
147,
25,
676
]
],
[
[
147,
63,
1461
],
[
1461,
23,
676
]
],
[
[
147,
24,
1430
],
[
1430,
24,
676
]
],
[
[
147,
24,
1654
],
[
1654,
... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipu... |
DB00209 | DB00264 | 352 | 88 | [
"DDInter1886",
"DDInter1200"
] | Trospium | Metoprolol | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Moderate | 1 | [
[
[
352,
24,
88
]
],
[
[
352,
24,
1121
],
[
1121,
1,
88
]
],
[
[
352,
24,
819
],
[
819,
40,
88
]
],
[
[
352,
6,
12523
],
[
12523,
45... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoprolol"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisoprolol"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol (Compound) resembles Metoprolol (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Metoprolol (Compound)
Tros... |
DB00436 | DB06292 | 323 | 549 | [
"DDInter179",
"DDInter474"
] | Bendroflumethiazide | Dapagliflozin | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
323,
24,
549
]
],
[
[
323,
24,
1344
],
[
1344,
40,
549
]
],
[
[
323,
21,
28898
],
[
28898,
60,
549
]
],
[
[
323,
63,
1179
],
[
1179,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagl... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Bendroflumethiazide (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Dapagliflozin (Compound)
Bendrofl... |
DB01157 | DB09498 | 304 | 810 | [
"DDInter1875",
"DDInter1715"
] | Trimetrexate | Strontium chloride Sr-89 | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
304,
24,
810
]
],
[
[
304,
63,
597
],
[
597,
24,
810
]
],
[
[
304,
24,
1362
],
[
1362,
24,
810
]
],
[
[
304,
24,
738
],
[
738,
6... | [
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramph... | Trimetrexate may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Trimetrexate may cause a moderate interaction that could exacerbate diseases when take... |
DB01132 | DB12015 | 1,130 | 1,033 | [
"DDInter1472",
"DDInter53"
] | Pioglitazone | Alpelisib | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1130,
24,
1033
]
],
[
[
1130,
24,
1254
],
[
1254,
24,
1033
]
],
[
[
1130,
25,
1510
],
[
1510,
24,
1033
]
],
[
[
1130,
63,
322
],
[
322... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Pioglitazone may lead to a major life threatening interaction when taken with Teriflunomide and T... |
DB00773 | DB12015 | 896 | 1,033 | [
"DDInter702",
"DDInter53"
] | Etoposide | Alpelisib | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
896,
24,
1033
]
],
[
[
896,
24,
738
],
[
738,
24,
1033
]
],
[
[
896,
63,
10
],
[
10,
24,
1033
]
],
[
[
896,
25,
1510
],
[
1510,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone may ca... |
DB00006 | DB10897 | 942 | 539 | [
"DDInter217",
"DDInter291"
] | Bivalirudin | Capsicum | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Capsicum (Chili pepper) allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
942,
23,
539
]
],
[
[
942,
24,
885
],
[
885,
23,
539
]
],
[
[
942,
25,
702
],
[
702,
23,
539
]
],
[
[
942,
25,
1421
],
[
1421,
6... | [
[
[
"Bivalirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Capsicum
Bivalirudin may lead to a major life threatening interaction when taken with Anagrelide and Anagrelide may caus... |
DB11581 | DB14840 | 1,456 | 861 | [
"DDInter1926",
"DDInter1601"
] | Venetoclax | Ripretinib | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Moderate | 1 | [
[
[
1456,
24,
861
]
],
[
[
1456,
25,
351
],
[
351,
24,
861
]
],
[
[
1456,
24,
214
],
[
214,
24,
861
]
],
[
[
1456,
63,
353
],
[
353,
... | [
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ripretinib"
]
],
[
[
"Venetoclax",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Ribociclib... | Venetoclax may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may ca... |
DB00445 | DB04844 | 322 | 843 | [
"DDInter655",
"DDInter1778"
] | Epirubicin | Tetrabenazine | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Moderate | 1 | [
[
[
322,
24,
843
]
],
[
[
322,
24,
479
],
[
479,
40,
843
]
],
[
[
322,
18,
3771
],
[
3771,
46,
843
]
],
[
[
322,
7,
15786
],
[
15786,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil (Compound) resembles Tetrabenazine (Compound)
Epirubicin (Compound) downregulates SUV39H1 (Gene) and SUV39H1 (Gene) is upregulated by Tetrabenazine (Compound)
Epirubicin (Compound) upregulates TCTN1 (Gene)... |
DB00459 | DB14730 | 640 | 1,412 | [
"DDInter21",
"DDInter264"
] | Acitretin | Calaspargase pegol | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
640,
24,
1412
]
],
[
[
640,
63,
322
],
[
322,
24,
1412
]
],
[
[
640,
24,
850
],
[
850,
24,
1412
]
],
[
[
640,
25,
1572
],
[
1572,
... | [
[
[
"Acitretin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Acitretin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
... | Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab ved... |
DB01234 | DB01309 | 1,220 | 1,254 | [
"DDInter513",
"DDInter933"
] | Dexamethasone | Insulin glulisine | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1220,
24,
1254
]
],
[
[
1220,
40,
1103
],
[
1103,
23,
1254
]
],
[
[
1220,
24,
1033
],
[
1033,
63,
1254
]
],
[
[
1220,
63,
1424
],
[
14... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Dexamethasone",
"{u} (Compound) resembles {v} (Compound)",
"Amcinonide"
],
[
"Amcinonide",
"{u} may ca... | Dexamethasone (Compound) resembles Amcinonide (Compound) and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Insulin glulisine
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moderate interaction t... |
DB01010 | DB08868 | 61 | 1,011 | [
"DDInter622",
"DDInter737"
] | Edrophonium | Fingolimod | A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Moderate | 1 | [
[
[
61,
24,
1011
]
],
[
[
61,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
61,
63,
751
],
[
751,
24,
1011
]
],
[
[
61,
24,
1276
],
[
1276,
... | [
[
[
"Edrophonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
]
],
[
[
"Edrophonium",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac arrest"
],
[
"Cardiac arrest",
"{u} (Side Eff... | Edrophonium (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Edrophonium may cause a moderate interaction that could exacerbate diseases when taken with Pyridostigmine and Pyridostigmine may cause a moderate interaction that could exacerbate diseases whe... |
DB00218 | DB00284 | 1,176 | 1,647 | [
"DDInter1247",
"DDInter11"
] | Moxifloxacin | Acarbose | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Moderate | 1 | [
[
[
1176,
24,
1647
]
],
[
[
1176,
24,
355
],
[
355,
40,
1647
]
],
[
[
1176,
21,
29047
],
[
29047,
60,
1647
]
],
[
[
1176,
24,
1645
],
[
16... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
]
],
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
],
[
... | Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and Lactulose (Compound) resembles Acarbose (Compound)
Moxifloxacin (Compound) causes Hepatic function abnormal (Side Effect) and Hepatic function abnormal (Side Effect) is caused by Acarbose (Compound)
Moxifloxacin m... |
DB00197 | DB06791 | 1,324 | 1,446 | [
"DDInter1881",
"DDInter1021"
] | Troglitazone | Lanreotide | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Moderate | 1 | [
[
[
1324,
24,
1446
]
],
[
[
1324,
24,
466
],
[
466,
62,
1446
]
],
[
[
1324,
24,
469
],
[
469,
24,
1446
]
],
[
[
1324,
24,
154
],
[
154,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanreotide"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Lanreotide
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Bromocriptine a... |
DB00731 | DB01021 | 1,144 | 674 | [
"DDInter1269",
"DDInter1861"
] | Nateglinide | Trichlormethiazide | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Moderate | 1 | [
[
[
1144,
24,
674
]
],
[
[
1144,
63,
1014
],
[
1014,
40,
674
]
],
[
[
1144,
24,
178
],
[
178,
1,
674
]
],
[
[
1144,
24,
359
],
[
359,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazide"
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles Tric... |
DB00649 | DB08871 | 231 | 36 | [
"DDInter1710",
"DDInter666"
] | Stavudine | Eribulin | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
231,
24,
36
]
],
[
[
231,
24,
1488
],
[
1488,
24,
36
]
],
[
[
231,
63,
168
],
[
168,
24,
36
]
],
[
[
231,
24,
384
],
[
384,
63,
... | [
[
[
"Stavudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Stavudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
[
... | Stavudine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Stavudine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezom... |
DB00876 | DB01142 | 1,414 | 1,264 | [
"DDInter658",
"DDInter593"
] | Eprosartan | Doxepin | Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1414,
24,
1264
]
],
[
[
1414,
24,
401
],
[
401,
24,
1264
]
],
[
[
1414,
6,
6017
],
[
6017,
45,
1264
]
],
[
[
1414,
21,
29226
],
[
2922... | [
[
[
"Eprosartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Eprosartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Eprosartan may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Eprosartan (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Doxepin (Compound)
Eprosartan (Compound... |
DB00381 | DB01259 | 376 | 392 | [
"DDInter79",
"DDInter1024"
] | Amlodipine | Lapatinib | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
376,
24,
392
]
],
[
[
376,
6,
4973
],
[
4973,
45,
392
]
],
[
[
376,
18,
10780
],
[
10780,
46,
392
]
],
[
[
376,
7,
7161
],
[
7161,
... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Amlodipine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Amlodipine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Amlodipine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is upregulated by Lapatinib (Compound)
Amlodipine (Compound) upregulates KLHDC2 (Gene) and KLHDC2 (Gene) is upregulated by Lapatinib (Compound)
Amlodipine (Compoun... |
DB01170 | DB08907 | 1,150 | 1,344 | [
"DDInter846",
"DDInter280"
] | Guanethidine | Canagliflozin | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem] | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1150,
24,
1344
]
],
[
[
1150,
24,
549
],
[
549,
1,
1344
]
],
[
[
1150,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
1150,
63,
1486
],
[
1486,
... | [
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]... | Guanethidine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Guanethidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Guanethidine may cause a moderate interaction that... |
DB01235 | DB12834 | 1,191 | 148 | [
"DDInter1054",
"DDInter1649"
] | Levodopa | Secnidazole | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
1191,
24,
148
]
],
[
[
1191,
24,
1593
],
[
1593,
24,
148
]
],
[
[
1191,
63,
597
],
[
597,
24,
148
]
],
[
[
1191,
24,
1593
],
[
1593,
... | [
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[
... | Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chlo... |
DB00196 | DB01320 | 600 | 651 | [
"DDInter743",
"DDInter783"
] | Fluconazole | Fosphenytoin | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Major | 2 | [
[
[
600,
25,
651
]
],
[
[
600,
23,
307
],
[
307,
1,
651
]
],
[
[
600,
25,
362
],
[
362,
1,
651
]
],
[
[
600,
6,
6017
],
[
6017,
45,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
"Modafinil... | Fluconazole may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Fosphenytoin (Compound)
Fluconazole may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Fluconazole (Co... |
DB00844 | DB08895 | 314 | 976 | [
"DDInter1257",
"DDInter1825"
] | Nalbuphine | Tofacitinib | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
314,
24,
976
]
],
[
[
314,
25,
407
],
[
407,
63,
976
]
],
[
[
314,
64,
475
],
[
475,
24,
976
]
],
[
[
314,
1,
828
],
[
828,
24,
... | [
[
[
"Nalbuphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Nalbuphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Opium"
],
[
"Opium",
... | Nalbuphine may lead to a major life threatening interaction when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Nalbuphine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that ... |
DB00427 | DB00575 | 1,233 | 1,020 | [
"DDInter1879",
"DDInter412"
] | Triprolidine | Clonidine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974. | Moderate | 1 | [
[
[
1233,
24,
1020
]
],
[
[
1233,
24,
1617
],
[
1617,
40,
1020
]
],
[
[
1233,
6,
12523
],
[
12523,
45,
1020
]
],
[
[
1233,
24,
1311
],
[
1... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Clonidine (Compound)
Triprolidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Clonidine (Compound)
Triprolidine may cause a moderate interaction that could e... |
DB00284 | DB14730 | 1,647 | 1,412 | [
"DDInter11",
"DDInter264"
] | Acarbose | Calaspargase pegol | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1647,
24,
1412
]
],
[
[
1647,
24,
322
],
[
322,
24,
1412
]
],
[
[
1647,
23,
126
],
[
126,
24,
1412
]
],
[
[
1647,
63,
912
],
[
912,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Acarbose may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfar... |
DB00877 | DB06292 | 629 | 549 | [
"DDInter1678",
"DDInter474"
] | Sirolimus | Dapagliflozin | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
629,
24,
549
]
],
[
[
629,
24,
1344
],
[
1344,
40,
549
]
],
[
[
629,
6,
8374
],
[
8374,
45,
549
]
],
[
[
629,
21,
29222
],
[
29222,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Sirolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Sirolimus (Compound) causes Hypoglycaemia (Side Effect) ... |
DB00357 | DB00468 | 1,051 | 1,424 | [
"DDInter71",
"DDInter1557"
] | Aminoglutethimide | Quinine | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Moderate | 1 | [
[
[
1051,
24,
1424
]
],
[
[
1051,
6,
7950
],
[
7950,
45,
1424
]
],
[
[
1051,
21,
28709
],
[
28709,
60,
1424
]
],
[
[
1051,
24,
307
],
[
30... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (... | Aminoglutethimide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Quinine (Compound)
Aminoglutethimide (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Quinine (Compound)
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases wh... |
DB00461 | DB00512 | 598 | 91 | [
"DDInter1254",
"DDInter1916"
] | Nabumetone | Vancomycin | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Moderate | 1 | [
[
[
598,
24,
91
]
],
[
[
598,
21,
28810
],
[
28810,
60,
91
]
],
[
[
598,
25,
663
],
[
663,
63,
91
]
],
[
[
598,
24,
1662
],
[
1662,
... | [
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vancomycin"
]
],
[
[
"Nabumetone",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal pain"
],
[
"Gastrointestinal pain",
"{... | Nabumetone (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Vancomycin (Compound)
Nabumetone may lead to a major life threatening interaction when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken... |
DB00250 | DB00601 | 10 | 453 | [
"DDInter475",
"DDInter1073"
] | Dapsone | Linezolid | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Moderate | 1 | [
[
[
10,
24,
453
]
],
[
[
10,
21,
28746
],
[
28746,
60,
453
]
],
[
[
10,
24,
770
],
[
770,
63,
453
]
],
[
[
10,
24,
522
],
[
522,
24,... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linezolid"
]
],
[
[
"Dapsone",
"{u} (Compound) causes {v} (Side Effect)",
"Erythema"
],
[
"Erythema",
"{u} (Side Effect) is caused by {v}... | Dapsone (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Linezolid (Compound)
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Linezolid
Daps... |
DB01211 | DB09083 | 609 | 880 | [
"DDInter393",
"DDInter996"
] | Clarithromycin | Ivabradine | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Major | 2 | [
[
[
609,
25,
880
]
],
[
[
609,
63,
480
],
[
480,
24,
880
]
],
[
[
609,
25,
1478
],
[
1478,
24,
880
]
],
[
[
609,
25,
159
],
[
159,
6... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivabradine"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Fo... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Clarithromycin may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may ... |
DB11627 | DB11921 | 1,367 | 1,019 | [
"DDInter860",
"DDInter492"
] | Hepatitis B Vaccine (Recombinant) | Deflazacort | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1367,
24,
1019
]
],
[
[
1367,
24,
270
],
[
270,
63,
1019
]
],
[
[
1367,
63,
629
],
[
629,
24,
1019
]
],
[
[
1367,
24,
1316
],
[
1316,
... | [
[
[
"Hepatitis B Vaccine (Recombinant)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Hepatitis B Vaccine (Recombinant)",
"{u} may cause a moderate interaction that could exacerbate diseases when take... | Hepatitis B Vaccine (Recombinant) may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Hepatitis B Vaccine (Recombinant) may cause a moderate interaction that could exacerba... |
DB00434 | DB04946 | 13 | 924 | [
"DDInter459",
"DDInter907"
] | Cyproheptadine | Iloperidone | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
13,
24,
924
]
],
[
[
13,
24,
1664
],
[
1664,
1,
924
]
],
[
[
13,
24,
519
],
[
519,
40,
924
]
],
[
[
13,
6,
10104
],
[
10104,
45,... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Iloperi... |
DB00512 | DB09134 | 91 | 1,552 | [
"DDInter1916",
"DDInter966"
] | Vancomycin | Ioversol | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Major | 2 | [
[
[
91,
25,
1552
]
],
[
[
91,
24,
242
],
[
242,
63,
1552
]
],
[
[
91,
24,
1680
],
[
1680,
24,
1552
]
],
[
[
91,
24,
848
],
[
848,
25... | [
[
[
"Vancomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioversol"
]
],
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
],
[
"Remdesivir",... | Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Etacrynic acid and Etac... |
DB00342 | DB12141 | 1,181 | 971 | [
"DDInter1770",
"DDInter817"
] | Terfenadine | Gilteritinib | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1181,
24,
971
]
],
[
[
1181,
23,
1247
],
[
1247,
23,
971
]
],
[
[
1181,
24,
485
],
[
485,
24,
971
]
],
[
[
1181,
24,
730
],
[
730,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidi... |
DB00757 | DB06663 | 1,166 | 1,154 | [
"DDInter581",
"DDInter1398"
] | Dolasetron | Pasireotide | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
1166,
25,
1154
]
],
[
[
1166,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
1166,
23,
112
],
[
112,
23,
1154
]
],
[
[
1166,
64,
88
],
[
88,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Dolasetron",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused b... | Dolasetron (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Dolasetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken... |
DB00026 | DB01234 | 1,184 | 1,220 | [
"DDInter94",
"DDInter513"
] | Anakinra | Dexamethasone | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1184,
24,
1220
]
],
[
[
1184,
24,
870
],
[
870,
1,
1220
]
],
[
[
1184,
24,
175
],
[
175,
40,
1220
]
],
[
[
1184,
24,
1382
],
[
1382,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexamet... |
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