drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00734 | DB00792 | 1,664 | 832 | [
"DDInter1605",
"DDInter1878"
] | Risperidone | Tripelennamine | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
1664,
24,
832
]
],
[
[
1664,
24,
100
],
[
100,
63,
832
]
],
[
[
1664,
24,
649
],
[
649,
1,
832
]
],
[
[
1664,
63,
1594
],
[
1594,
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Clofe... |
DB00804 | DB01224 | 1,507 | 623 | [
"DDInter543",
"DDInter1553"
] | Dicyclomine | Quetiapine | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
1507,
24,
623
]
],
[
[
1507,
63,
695
],
[
695,
1,
623
]
],
[
[
1507,
24,
1178
],
[
1178,
1,
623
]
],
[
[
1507,
6,
7992
],
[
7992,
... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Quetiapine (Compound)
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Quetiapine (... |
DB00434 | DB00906 | 13 | 1,567 | [
"DDInter459",
"DDInter1801"
] | Cyproheptadine | Tiagabine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. | Moderate | 1 | [
[
[
13,
24,
1567
]
],
[
[
13,
21,
29544
],
[
29544,
60,
1567
]
],
[
[
13,
24,
530
],
[
530,
24,
1567
]
],
[
[
13,
24,
537
],
[
537,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiagabine"
]
],
[
[
"Cyproheptadine",
"{u} (Compound) causes {v} (Side Effect)",
"Weight increased"
],
[
"Weight increased",
"{u} ... | Cyproheptadine (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Tiagabine (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may cause a moderate interaction that could exacerbate diseases wh... |
DB00277 | DB00976 | 1,031 | 1,056 | [
"DDInter1791",
"DDInter1758"
] | Theophylline | Telithromycin | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Moderate | 1 | [
[
[
1031,
24,
1056
]
],
[
[
1031,
63,
1570
],
[
1570,
40,
1056
]
],
[
[
1031,
6,
7950
],
[
7950,
45,
1056
]
],
[
[
1031,
21,
28681
],
[
28... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telithromycin"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin (Compound) resembles Telithromycin (Compound)
Theophylline (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Telithromycin (Compound)
Theophylline (Compound) causes Hypersensitivity (Sid... |
DB01242 | DB12245 | 1,237 | 823 | [
"DDInter410",
"DDInter1863"
] | Clomipramine | Triclabendazole | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1237,
24,
823
]
],
[
[
1237,
62,
112
],
[
112,
23,
823
]
],
[
[
1237,
63,
1010
],
[
1010,
24,
823
]
],
[
[
1237,
64,
1494
],
[
1494,
... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Clomipramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]... | Clomipramine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine... |
DB00641 | DB09073 | 467 | 951 | [
"DDInter1675",
"DDInter1379"
] | Simvastatin | Palbociclib | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
467,
24,
951
]
],
[
[
467,
24,
1476
],
[
1476,
63,
951
]
],
[
[
467,
24,
259
],
[
259,
24,
951
]
],
[
[
467,
63,
134
],
[
134,
2... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Ril... |
DB00802 | DB09074 | 1,322 | 1,362 | [
"DDInter43",
"DDInter1327"
] | Alfentanil | Olaparib | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
1322,
24,
1362
]
],
[
[
1322,
24,
250
],
[
250,
24,
1362
]
],
[
[
1322,
63,
353
],
[
353,
24,
1362
]
],
[
[
1322,
24,
1619
],
[
1619,
... | [
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Blinatumomab"
],
[
... | Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Blinatumomab and Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Gr... |
DB00207 | DB06603 | 1,570 | 39 | [
"DDInter157",
"DDInter1387"
] | Azithromycin | Panobinostat | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1570,
25,
39
]
],
[
[
1570,
23,
112
],
[
112,
23,
39
]
],
[
[
1570,
63,
912
],
[
912,
24,
39
]
],
[
[
1570,
24,
455
],
[
455,
24... | [
[
[
"Azithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Azithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Azithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Interferon be... |
DB01073 | DB14443 | 1,488 | 987 | [
"DDInter745",
"DDInter1931"
] | Fludarabine | Vibrio cholerae CVD 103-HgR strain live antigen | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
1488,
24,
987
]
],
[
[
1488,
24,
1480
],
[
1480,
24,
987
]
],
[
[
1488,
63,
141
],
[
141,
24,
987
]
],
[
[
1488,
40,
1426
],
[
1426,
... | [
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Fludarabine may cause a moderate interaction that could exacerbate diseases wh... |
DB00307 | DB00460 | 1,101 | 612 | [
"DDInter202",
"DDInter1929"
] | Bexarotene | Verteporfin | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Moderate | 1 | [
[
[
1101,
24,
612
]
],
[
[
1101,
21,
29044
],
[
29044,
60,
612
]
],
[
[
1101,
24,
392
],
[
392,
63,
612
]
],
[
[
1101,
23,
1419
],
[
1419,... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verteporfin"
]
],
[
[
"Bexarotene",
"{u} (Compound) causes {v} (Side Effect)",
"Pneumonia"
],
[
"Pneumonia",
"{u} (Side Effect) is cau... | Bexarotene (Compound) causes Pneumonia (Side Effect) and Pneumonia (Side Effect) is caused by Verteporfin (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Vertepor... |
DB00467 | DB09038 | 1,467 | 1,450 | [
"DDInter644",
"DDInter636"
] | Enoxacin | Empagliflozin | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1467,
24,
1450
]
],
[
[
1467,
1,
872
],
[
872,
24,
1450
]
],
[
[
1467,
25,
1486
],
[
1486,
24,
1450
]
],
[
[
1467,
64,
1179
],
[
1179,... | [
[
[
"Enoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Enoxacin",
"{u} (Compound) resembles {v} (Compound)",
"Gemifloxacin"
],
[
"Gemifloxacin",
"{u} may cause a mode... | Enoxacin (Compound) resembles Gemifloxacin (Compound) and Gemifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Enoxacin may lead to a major life threatening interaction when taken with Methylprednisolone and Methylprednisolone may cause a moderate interaction that c... |
DB11248 | DB11817 | 1,193 | 1,259 | [
"DDInter1965",
"DDInter165"
] | Zinc gluconate | Baricitinib | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA. It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wit... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Minor | 0 | [
[
[
1193,
23,
1259
]
],
[
[
1193,
62,
1220
],
[
1220,
25,
1259
]
],
[
[
1193,
23,
1316
],
[
1316,
25,
1259
]
],
[
[
1193,
23,
1303
],
[
13... | [
[
[
"Zinc gluconate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Baricitinib"
]
],
[
[
"Zinc gluconate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexamethasone"
],
... | Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone may lead to a major life threatening interaction when taken with Baricitinib
Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Durvalumab and Durvalumab... |
DB00357 | DB01254 | 1,051 | 1,213 | [
"DDInter71",
"DDInter484"
] | Aminoglutethimide | Dasatinib | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1051,
24,
1213
]
],
[
[
1051,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
1051,
18,
20102
],
[
20102,
57,
1213
]
],
[
[
1051,
21,
28882
],
[
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v}... | Aminoglutethimide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Aminoglutethimide (Compound) downregulates FAM57A (Gene) and FAM57A (Gene) is downregulated by Dasatinib (Compound)
Aminoglutethimide (Compound) causes Body temperature increased (Side Effect) and Body temperature increa... |
DB00358 | DB05294 | 1,010 | 1,069 | [
"DDInter1140",
"DDInter1917"
] | Mefloquine | Vandetanib | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
1010,
25,
1069
]
],
[
[
1010,
6,
8374
],
[
8374,
45,
1069
]
],
[
[
1010,
21,
28883
],
[
28883,
60,
1069
]
],
[
[
1010,
23,
1247
],
[
1... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vandeta... | Mefloquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound)
Mefloquine (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Vandetanib (Compound)
Mefloquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxaz... |
DB00495 | DB08868 | 139 | 1,011 | [
"DDInter1961",
"DDInter737"
] | Zidovudine | Fingolimod | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
139,
25,
1011
]
],
[
[
139,
6,
8374
],
[
8374,
45,
1011
]
],
[
[
139,
21,
28792
],
[
28792,
60,
1011
]
],
[
[
139,
25,
1613
],
[
1613,... | [
[
[
"Zidovudine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Zidovudine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Fingoli... | Zidovudine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Zidovudine (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Fingolimod (Compound)
Zidovudine may lead to a major life threatening interaction when taken with Pe... |
DB00307 | DB01234 | 1,101 | 1,220 | [
"DDInter202",
"DDInter513"
] | Bexarotene | Dexamethasone | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1101,
24,
1220
]
],
[
[
1101,
24,
870
],
[
870,
1,
1220
]
],
[
[
1101,
24,
175
],
[
175,
40,
1220
]
],
[
[
1101,
5,
11555
],
[
11555,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dex... |
DB00581 | DB01087 | 355 | 1,520 | [
"DDInter1018",
"DDInter1520"
] | Lactulose | Primaquine | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
355,
24,
1520
]
],
[
[
355,
24,
1487
],
[
1487,
64,
1520
]
],
[
[
355,
21,
28722
],
[
28722,
60,
1520
]
],
[
[
355,
63,
508
],
[
508,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
],
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Lactulose (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Primaquine (Compound)
Lac... |
DB00459 | DB00717 | 640 | 1,197 | [
"DDInter21",
"DDInter1312"
] | Acitretin | Norethisterone | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Major | 2 | [
[
[
640,
25,
1197
]
],
[
[
640,
64,
566
],
[
566,
40,
1197
]
],
[
[
640,
6,
1829
],
[
1829,
45,
1197
]
],
[
[
640,
7,
2023
],
[
2023,
... | [
[
[
"Acitretin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Norethisterone"
]
],
[
[
"Acitretin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levonorgestrel"
],
[
"Levonorgestrel",
... | Acitretin may lead to a major life threatening interaction when taken with Levonorgestrel and Levonorgestrel (Compound) resembles Norethisterone (Compound)
Acitretin (Compound) binds ALB (Gene) and ALB (Gene) is bound by Norethisterone (Compound)
Acitretin (Compound) upregulates RAP1GAP (Gene) and RAP1GAP (Gene) is upr... |
DB00014 | DB01067 | 521 | 959 | [
"DDInter839",
"DDInter826"
] | Goserelin | Glipizide | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
521,
24,
959
]
],
[
[
521,
24,
245
],
[
245,
40,
959
]
],
[
[
521,
24,
1411
],
[
1411,
1,
959
]
],
[
[
521,
21,
28987
],
[
28987,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound)
... |
DB01232 | DB09045 | 1,327 | 52 | [
"DDInter1640",
"DDInter607"
] | Saquinavir | Dulaglutide | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
1327,
24,
52
]
],
[
[
1327,
24,
170
],
[
170,
23,
52
]
],
[
[
1327,
64,
609
],
[
609,
24,
52
]
],
[
[
1327,
63,
870
],
[
870,
24... | [
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
[
... | Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Saquinavir may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin m... |
DB01229 | DB09570 | 973 | 1,480 | [
"DDInter1378",
"DDInter1002"
] | Paclitaxel (protein-bound) | Ixazomib | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
973,
24,
1480
]
],
[
[
973,
24,
987
],
[
987,
63,
1480
]
],
[
[
973,
63,
440
],
[
440,
24,
1480
]
],
[
[
973,
24,
248
],
[
248,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR s... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen and Vibrio cholerae CVD 103-HgR strain live antigen may cause a moderate interact... |
DB00906 | DB01176 | 1,567 | 537 | [
"DDInter1801",
"DDInter453"
] | Tiagabine | Cyclizine | Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1567,
24,
537
]
],
[
[
1567,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1567,
21,
29054
],
[
29054,
60,
537
]
],
[
[
1567,
24,
849
],
[
849,... | [
[
[
"Tiagabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Tiagabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],
[
... | Tiagabine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Tiagabine (Compound) causes Speech disorder (Side Effect) and Speech disorder (Side Effect) is caused by Cyclizine... |
DB00807 | DB01612 | 1,120 | 1,637 | [
"DDInter1536",
"DDInter92"
] | Proparacaine (ophthalmic) | Amyl Nitrite | Proparacaine is a benzoate ester. | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
1120,
24,
1637
]
],
[
[
1120,
40,
1311
],
[
1311,
24,
1084
],
[
1084,
63,
1637
]
],
[
[
1120,
1,
1401
],
[
1401,
24,
1376
],
[
1376,
... | [
[
[
"Proparacaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Proparacaine",
"{u} (Compound) resembles {v} (Compound)",
"Metoclopramide"
],
[
"Metoclopramide",
"{u} may c... | Proparacaine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Proparacaine (Compound) resembles Metoclopramide (Compound) and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Lofexidine and Lofexidine may cause a moderate interact... |
DB00018 | DB09268 | 199 | 1,662 | [
"DDInter945",
"DDInter1464"
] | Interferon alfa-n3 | Picosulfuric acid | Purified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms including 2a, 2b and 2c). 166 residues, some are glycosylated (MW range from 16 kD to 27 kD). | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
199,
24,
1662
]
],
[
[
199,
24,
1031
],
[
1031,
24,
1662
]
],
[
[
199,
25,
593
],
[
593,
24,
1662
]
],
[
[
199,
24,
1031
],
[
1031,
... | [
[
[
"Interferon alfa-n3",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Interferon alfa-n3",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theo... | Interferon alfa-n3 may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Interferon alfa-n3 may lead to a major life threatening interaction when taken with Bupropion... |
DB11989 | DB12834 | 1,434 | 148 | [
"DDInter183",
"DDInter1649"
] | Benznidazole | Secnidazole | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
1434,
24,
148
]
],
[
[
1434,
63,
1593
],
[
1593,
24,
148
]
],
[
[
1434,
24,
1330
],
[
1330,
63,
148
]
],
[
[
1434,
24,
110
],
[
110,
... | [
[
[
"Benznidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Benznidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
... | Benznidazole may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Benznidazole may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab and Na... |
DB00526 | DB00738 | 1,555 | 485 | [
"DDInter1355",
"DDInter1420"
] | Oxaliplatin | Pentamidine | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Moderate | 1 | [
[
[
1555,
24,
485
]
],
[
[
1555,
6,
9842
],
[
9842,
45,
485
]
],
[
[
1555,
23,
1247
],
[
1247,
62,
485
]
],
[
[
1555,
24,
112
],
[
112,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
]
],
[
[
"Oxaliplatin",
"{u} (Compound) binds {v} (Gene)",
"CYP1A1"
],
[
"CYP1A1",
"{u} (Gene) is bound by {v} (Compound... | Oxaliplatin (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Pentamidine (Compound)
Oxaliplatin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Pentamidine
Oxalip... |
DB00039 | DB08889 | 1,253 | 350 | [
"DDInter1380",
"DDInter299"
] | Palifermin | Carfilzomib | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
1253,
24,
350
]
],
[
[
1253,
24,
482
],
[
482,
24,
350
]
],
[
[
1253,
63,
1451
],
[
1451,
24,
350
]
],
[
[
1253,
24,
1330
],
[
1330,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfa-n1 a... |
DB00196 | DB01211 | 600 | 609 | [
"DDInter743",
"DDInter393"
] | Fluconazole | Clarithromycin | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Minor | 0 | [
[
[
600,
23,
609
]
],
[
[
600,
24,
1570
],
[
1570,
24,
609
]
],
[
[
600,
6,
4973
],
[
4973,
45,
609
]
],
[
[
600,
7,
4603
],
[
4603,
... | [
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clarithromycin"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Fluconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Flucon... |
DB00745 | DB11837 | 307 | 1,297 | [
"DDInter1236",
"DDInter1351"
] | Modafinil | Osilodrostat | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
307,
24,
1297
]
],
[
[
307,
23,
1135
],
[
1135,
23,
1297
]
],
[
[
307,
24,
466
],
[
466,
62,
1297
]
],
[
[
307,
24,
1320
],
[
1320,
... | [
[
[
"Modafinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Modafinil may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Modafinil may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutami... |
DB00328 | DB00331 | 831 | 1,645 | [
"DDInter921",
"DDInter1164"
] | Indomethacin | Metformin | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Moderate | 1 | [
[
[
831,
24,
1645
]
],
[
[
831,
21,
28714
],
[
28714,
60,
1645
]
],
[
[
831,
25,
629
],
[
629,
63,
1645
]
],
[
[
831,
24,
870
],
[
870,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
]
],
[
[
"Indomethacin",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is cau... | Indomethacin (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Metformin (Compound)
Indomethacin may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Metformin
Indomethacin ... |
DB01284 | DB08895 | 1,042 | 976 | [
"DDInter1782",
"DDInter1825"
] | Tetracosactide | Tofacitinib | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Major | 2 | [
[
[
1042,
25,
976
]
],
[
[
1042,
24,
200
],
[
200,
63,
976
]
],
[
[
1042,
63,
1020
],
[
1020,
24,
976
]
],
[
[
1042,
24,
1430
],
[
1430,
... | [
[
[
"Tetracosactide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
],
[
... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB01406 | DB11581 | 984 | 1,456 | [
"DDInter472",
"DDInter1926"
] | Danazol | Venetoclax | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Moderate | 1 | [
[
[
984,
24,
1456
]
],
[
[
984,
25,
1135
],
[
1135,
23,
1456
]
],
[
[
984,
24,
1476
],
[
1476,
63,
1456
]
],
[
[
984,
24,
594
],
[
594,
... | [
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venetoclax"
]
],
[
[
"Danazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Danazol may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Danazol may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate... |
DB00180 | DB06448 | 1,351 | 171 | [
"DDInter749",
"DDInter1087"
] | Flunisolide | Lonafarnib | Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid with anti-inflammatory actions. It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves activation of glucocorticoid receptors. | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Moderate | 1 | [
[
[
1351,
24,
171
]
],
[
[
1351,
40,
423
],
[
423,
24,
171
]
],
[
[
1351,
25,
1064
],
[
1064,
24,
171
]
],
[
[
1351,
23,
659
],
[
659,
... | [
[
[
"Flunisolide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lonafarnib"
]
],
[
[
"Flunisolide",
"{u} (Compound) resembles {v} (Compound)",
"Ciclesonide"
],
[
"Ciclesonide",
"{u} may cause a mod... | Flunisolide (Compound) resembles Ciclesonide (Compound) and Ciclesonide may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Flunisolide may lead to a major life threatening interaction when taken with Cladribine and Cladribine may cause a moderate interaction that could exacerbate... |
DB01082 | DB01336 | 1,448 | 545 | [
"DDInter1713",
"DDInter1198"
] | Streptomycin | Metocurine | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Dimethyltubocurarinium (INN) or metocurine (USAN), also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant. Patients on chronic anticonvulsant drugs are relatively resistant to metocurine. | Major | 2 | [
[
[
1448,
25,
545
]
],
[
[
1448,
25,
1217
],
[
1217,
40,
545
]
],
[
[
1448,
63,
91
],
[
91,
24,
545
]
],
[
[
1448,
62,
608
],
[
608,
... | [
[
[
"Streptomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metocurine"
]
],
[
[
"Streptomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tubocurarine"
],
[
"Tubocurarine",
... | Streptomycin may lead to a major life threatening interaction when taken with Tubocurarine and Tubocurarine (Compound) resembles Metocurine (Compound)
Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may cause a moderate interaction that could exacer... |
DB00468 | DB04946 | 1,424 | 924 | [
"DDInter1557",
"DDInter907"
] | Quinine | Iloperidone | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Major | 2 | [
[
[
1424,
25,
924
]
],
[
[
1424,
24,
1664
],
[
1664,
1,
924
]
],
[
[
1424,
25,
1425
],
[
1425,
25,
924
]
],
[
[
1424,
24,
519
],
[
519,
... | [
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloperidone"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
"Risperidone",
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Quinine may lead to a major life threatening interaction when taken with Cisapride and Cisapride may lead to a major life threatening interaction when taken wit... |
DB00850 | DB01218 | 1,630 | 1,493 | [
"DDInter1432",
"DDInter852"
] | Perphenazine | Halofantrine | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
1630,
25,
1493
]
],
[
[
1630,
6,
3486
],
[
3486,
45,
1493
]
],
[
[
1630,
18,
2183
],
[
2183,
57,
1493
]
],
[
[
1630,
21,
28809
],
[
28... | [
[
[
"Perphenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Perphenazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"H... | Perphenazine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Halofantrine (Compound)
Perphenazine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Halofantrine (Compound)
Perphenazine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Halofantrine (... |
DB00902 | DB09104 | 104 | 286 | [
"DDInter1168",
"DDInter1118"
] | Methdilazine | Magnesium hydroxide | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Minor | 0 | [
[
[
104,
23,
286
]
],
[
[
104,
40,
820
],
[
820,
23,
286
]
],
[
[
104,
63,
1119
],
[
1119,
23,
286
]
],
[
[
104,
24,
401
],
[
401,
2... | [
[
[
"Methdilazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Methdilazine",
"{u} (Compound) resembles {v} (Compound)",
"Alimemazine"
],
[
"Alimemazine",
"{u} may ca... | Methdilazine (Compound) resembles Alimemazine (Compound) and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepoxide and Chlordiazepoxide may cause a minor ... |
DB05812 | DB08868 | 1,374 | 1,011 | [
"DDInter8",
"DDInter737"
] | Abiraterone | Fingolimod | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1374,
25,
1011
]
],
[
[
1374,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
1374,
21,
28792
],
[
28792,
60,
1011
]
],
[
[
1374,
62,
1247
],
[
... | [
[
[
"Abiraterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Abiraterone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Fingo... | Abiraterone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Abiraterone (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Fingolimod (Compound)
Abiraterone may cause a minor interaction that can limit clinical effects wh... |
DB00682 | DB00880 | 126 | 359 | [
"DDInter1951",
"DDInter360"
] | Warfarin | Chlorothiazide | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Minor | 0 | [
[
[
126,
23,
359
]
],
[
[
126,
23,
1577
],
[
1577,
1,
359
]
],
[
[
126,
62,
1014
],
[
1014,
1,
359
]
],
[
[
126,
63,
964
],
[
964,
2... | [
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chlorothiazide"
]
],
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroflumethiazide"
],
... | Warfarin may cause a minor interaction that can limit clinical effects when taken with Hydroflumethiazide and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound)
Warfarin may cause a minor interaction that can limit clinical effects when taken with Benzthiazide and Benzthiazide (Compound) resembles Chloro... |
DB00717 | DB06655 | 1,197 | 5 | [
"DDInter1312",
"DDInter1077"
] | Norethisterone | Liraglutide | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
1197,
24,
5
]
],
[
[
1197,
64,
353
],
[
353,
23,
5
]
],
[
[
1197,
63,
245
],
[
245,
24,
5
]
],
[
[
1197,
24,
1411
],
[
1411,
24,... | [
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Norethisterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Griseofulvin"
],
[
... | Norethisterone may lead to a major life threatening interaction when taken with Griseofulvin and Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiri... |
DB09570 | DB11627 | 1,480 | 1,367 | [
"DDInter1002",
"DDInter860"
] | Ixazomib | Hepatitis B Vaccine (Recombinant) | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
1480,
24,
1367
]
],
[
[
1480,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
1480,
63,
259
],
[
259,
24,
1367
]
],
[
[
1480,
24,
738
],
[
738,
... | [
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Ixazomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
... | Ixazomib may lead to a major life threatening interaction when taken with Cladribine and Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Ri... |
DB00570 | DB08826 | 147 | 1,292 | [
"DDInter1936",
"DDInter489"
] | Vinblastine | Deferiprone | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
147,
25,
1292
]
],
[
[
147,
21,
28809
],
[
28809,
60,
1292
]
],
[
[
147,
24,
1017
],
[
1017,
63,
1292
]
],
[
[
147,
24,
45
],
[
45,
... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Vinblastine",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) is caused by {v} (C... | Vinblastine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Deferiprone (Compound)
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Defe... |
DB00530 | DB01125 | 1,195 | 279 | [
"DDInter667",
"DDInter98"
] | Erlotinib | Anisindione | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Moderate | 1 | [
[
[
1195,
24,
279
]
],
[
[
1195,
24,
913
],
[
913,
63,
279
]
],
[
[
1195,
1,
883
],
[
883,
24,
279
]
],
[
[
1195,
25,
660
],
[
660,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
],
[
... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Anisindione
Erlotinib (Compound) resembles Gefitinib (Compound) and Gefitinib may cause a moderate interaction that could ... |
DB00791 | DB06372 | 132 | 259 | [
"DDInter1902",
"DDInter1594"
] | Uracil mustard | Rilonacept | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
132,
24,
259
]
],
[
[
132,
63,
1461
],
[
1461,
23,
259
]
],
[
[
132,
24,
1367
],
[
1367,
63,
259
]
],
[
[
132,
24,
4
],
[
4,
24,... | [
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
... | Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vacci... |
DB01185 | DB11921 | 155 | 1,019 | [
"DDInter759",
"DDInter492"
] | Fluoxymesterone | Deflazacort | An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
155,
24,
1019
]
],
[
[
155,
40,
443
],
[
443,
24,
1019
]
],
[
[
155,
63,
959
],
[
959,
24,
1019
]
],
[
[
155,
1,
1026
],
[
1026,
... | [
[
[
"Fluoxymesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Fluoxymesterone",
"{u} (Compound) resembles {v} (Compound)",
"Spironolactone"
],
[
"Spironolactone",
"{u} ... | Fluoxymesterone (Compound) resembles Spironolactone (Compound) and Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Fluoxymesterone may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate inter... |
DB00539 | DB00794 | 11 | 759 | [
"DDInter1837",
"DDInter1521"
] | Toremifene | Primidone | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Major | 2 | [
[
[
11,
25,
759
]
],
[
[
11,
25,
697
],
[
697,
40,
759
]
],
[
[
11,
64,
362
],
[
362,
1,
759
]
],
[
[
11,
6,
7950
],
[
7950,
45,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primidone"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenobarbital"
],
[
"Phenobarbital",
"... | Toremifene may lead to a major life threatening interaction when taken with Phenobarbital and Phenobarbital (Compound) resembles Primidone (Compound)
Toremifene may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin (Compound) resembles Primidone (Compound)
Toremifene (Compound) binds ... |
DB00488 | DB06674 | 196 | 908 | [
"DDInter57",
"DDInter837"
] | Altretamine | Golimumab | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
196,
25,
908
]
],
[
[
196,
63,
1461
],
[
1461,
23,
908
]
],
[
[
196,
24,
697
],
[
697,
24,
908
]
],
[
[
196,
24,
200
],
[
200,
6... | [
[
[
"Altretamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Altretamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Altretamine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Golimumab
Altretamine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenob... |
DB08885 | DB14444 | 363 | 151 | [
"DDInter33",
"DDInter924"
] | Aflibercept | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Dalt... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
363,
24,
151
]
],
[
[
363,
63,
66
],
[
66,
24,
151
]
],
[
[
363,
25,
375
],
[
375,
24,
151
]
],
[
[
363,
64,
1066
],
[
1066,
24,... | [
[
[
"Aflibercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Aflibercept",
"{u} may cause a moderate interaction that could... | Aflibercept may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Aflibercept may lead to a major life... |
DB00916 | DB06699 | 112 | 774 | [
"DDInter1202",
"DDInter493"
] | Metronidazole | Degarelix | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Minor | 0 | [
[
[
112,
23,
774
]
],
[
[
112,
62,
521
],
[
521,
1,
774
]
],
[
[
112,
21,
29232
],
[
29232,
60,
774
]
],
[
[
112,
23,
1247
],
[
1247,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Degarelix"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Goserelin"
],
[
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Metronidazole (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Metronidazole may cause a minor interaction ... |
DB06274 | DB08899 | 574 | 129 | [
"DDInter59",
"DDInter649"
] | Alvimopan | Enzalutamide | Alvimopan is a peripherally acting μ opioid antagonist. It is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
574,
24,
129
]
],
[
[
574,
21,
29034
],
[
29034,
60,
129
]
],
[
[
574,
1,
215
],
[
215,
24,
129
]
],
[
[
574,
64,
675
],
[
675,
... | [
[
[
"Alvimopan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Alvimopan",
"{u} (Compound) causes {v} (Side Effect)",
"Urinary tract disorder"
],
[
"Urinary tract disorder",
... | Alvimopan (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Enzalutamide (Compound)
Alvimopan (Compound) resembles Indinavir (Compound) and Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide
Alvimopan may lead... |
DB00934 | DB01169 | 413 | 57 | [
"DDInter1124",
"DDInter120"
] | Maprotiline | Arsenic trioxide | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
413,
25,
57
]
],
[
[
413,
7,
2067
],
[
2067,
45,
57
]
],
[
[
413,
6,
4973
],
[
4973,
45,
57
]
],
[
[
413,
62,
112
],
[
112,
23,
... | [
[
[
"Maprotiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Maprotiline",
"{u} (Compound) upregulates {v} (Gene)",
"IKBKB"
],
[
"IKBKB",
"{u} (Gene) is bound by {v} (Compound)",
... | Maprotiline (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is bound by Arsenic trioxide (Compound)
Maprotiline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Arsenic trioxide (Compound)
Maprotiline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronid... |
DB00277 | DB00787 | 1,031 | 387 | [
"DDInter1791",
"DDInter25"
] | Theophylline | Acyclovir | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young a... | Minor | 0 | [
[
[
1031,
23,
387
]
],
[
[
1031,
7,
5415
],
[
5415,
46,
387
]
],
[
[
1031,
18,
2097
],
[
2097,
57,
387
]
],
[
[
1031,
21,
29118
],
[
29118... | [
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acyclovir"
]
],
[
[
"Theophylline",
"{u} (Compound) upregulates {v} (Gene)",
"UBQLN2"
],
[
"UBQLN2",
"{u} (Gene) is upregulated by {v}... | Theophylline (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Acyclovir (Compound)
Theophylline (Compound) downregulates ERBB2 (Gene) and ERBB2 (Gene) is downregulated by Acyclovir (Compound)
Theophylline (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Acyc... |
DB01222 | DB08816 | 617 | 578 | [
"DDInter246",
"DDInter1802"
] | Budesonide | Ticagrelor | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
617,
24,
578
]
],
[
[
617,
6,
8374
],
[
8374,
45,
578
]
],
[
[
617,
21,
28646
],
[
28646,
60,
578
]
],
[
[
617,
63,
336
],
[
336,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Budesonide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Budesonide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ticagrelor (Compound)
Budesonide (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Budesonide may cause a m... |
DB00305 | DB14711 | 377 | 779 | [
"DDInter1232",
"DDInter1680"
] | Mitomycin | Smallpox (Vaccinia) Vaccine, Live | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
377,
25,
779
]
],
[
[
377,
64,
1064
],
[
1064,
25,
779
]
],
[
[
377,
25,
1377
],
[
1377,
25,
779
]
],
[
[
377,
24,
147
],
[
147,
... | [
[
[
"Mitomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Mitomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Clad... | Mitomycin may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Mitomycin may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may lead to a maj... |
DB01044 | DB01259 | 246 | 392 | [
"DDInter809",
"DDInter1024"
] | Gatifloxacin | Lapatinib | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Major | 2 | [
[
[
246,
25,
392
]
],
[
[
246,
18,
10375
],
[
10375,
57,
392
]
],
[
[
246,
21,
28688
],
[
28688,
60,
392
]
],
[
[
246,
62,
112
],
[
112,
... | [
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lapatinib"
]
],
[
[
"Gatifloxacin",
"{u} (Compound) downregulates {v} (Gene)",
"RPS4Y1"
],
[
"RPS4Y1",
"{u} (Gene) is downregulated by {v} (Compoun... | Gatifloxacin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Lapatinib (Compound)
Gatifloxacin (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Lapatinib (Compound)
Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with M... |
DB00227 | DB09122 | 1,463 | 1,613 | [
"DDInter1098",
"DDInter1409"
] | Lovastatin | Peginterferon beta-1a | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1463,
24,
1613
]
],
[
[
1463,
64,
600
],
[
600,
24,
1613
]
],
[
[
1463,
63,
168
],
[
168,
24,
1613
]
],
[
[
1463,
24,
267
],
[
267,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Lovastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
... | Lovastatin may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezom... |
DB00575 | DB00620 | 1,020 | 175 | [
"DDInter412",
"DDInter1855"
] | Clonidine | Triamcinolone | Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974. | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Moderate | 1 | [
[
[
1020,
24,
175
]
],
[
[
1020,
24,
1573
],
[
1573,
1,
175
]
],
[
[
1020,
24,
617
],
[
617,
40,
175
]
],
[
[
1020,
63,
251
],
[
251,
... | [
[
[
"Clonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
]
],
[
[
"Clonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Triamcinolone (Compou... |
DB01227 | DB01344 | 1,301 | 1,231 | [
"DDInter1043",
"DDInter1830"
] | Levacetylmethadol | Tolevamer | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Major | 2 | [
[
[
1301,
25,
1231
]
],
[
[
1301,
64,
870
],
[
870,
24,
1231
]
],
[
[
1301,
24,
603
],
[
603,
63,
1231
]
],
[
[
1301,
25,
1220
],
[
1220,
... | [
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tolevamer"
]
],
[
[
"Levacetylmethadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludrocortisone"
],
[
"Fludroc... | Levacetylmethadol may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer
Levacetylmethadol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium cit... |
DB00678 | DB00945 | 240 | 1,479 | [
"DDInter1095",
"DDInter20"
] | Losartan | Acetylsalicylic acid | Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough simila... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
240,
24,
1479
]
],
[
[
240,
5,
11576
],
[
11576,
44,
1479
]
],
[
[
240,
6,
10215
],
[
10215,
45,
1479
]
],
[
[
240,
21,
29232
],
[
292... | [
[
[
"Losartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Losartan",
"{u} (Compound) treats {v} (Disease)",
"coronary artery disease"
],
[
"coronary artery disease",
... | Losartan (Compound) treats coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Acetylsalicylic acid (Compound)
Losartan (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Acetylsalicylic acid (Compound)
Losartan (Compound) causes Urticaria (Side Effect) and Urticaria (Side ... |
DB00379 | DB08904 | 143 | 375 | [
"DDInter1206",
"DDInter342"
] | Mexiletine | Certolizumab pegol | Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
143,
24,
375
]
],
[
[
143,
63,
608
],
[
608,
24,
375
]
],
[
[
143,
64,
1031
],
[
1031,
24,
375
]
],
[
[
143,
24,
1303
],
[
1303,
... | [
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
... | Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Mexiletine may lead to a major life threatening interaction when taken with Theophylline and Theophylline ... |
DB00620 | DB10989 | 175 | 496 | [
"DDInter1855",
"DDInter858"
] | Triamcinolone | Hepatitis A Vaccine | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
175,
24,
496
]
],
[
[
175,
24,
4
],
[
4,
24,
496
]
],
[
[
175,
63,
1101
],
[
1101,
24,
496
]
],
[
[
175,
40,
1220
],
[
1220,
24,... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine ... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Triamcinolone may cause a moderate interaction that could exacerbate d... |
DB00285 | DB12141 | 1,100 | 971 | [
"DDInter1927",
"DDInter817"
] | Venlafaxine | Gilteritinib | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1100,
24,
971
]
],
[
[
1100,
23,
112
],
[
112,
23,
971
]
],
[
[
1100,
24,
485
],
[
485,
24,
971
]
],
[
[
1100,
24,
823
],
[
823,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Venlafaxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Venlafaxine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and... |
DB04844 | DB08881 | 843 | 868 | [
"DDInter1778",
"DDInter1925"
] | Tetrabenazine | Vemurafenib | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
843,
25,
868
]
],
[
[
843,
6,
12523
],
[
12523,
45,
868
]
],
[
[
843,
18,
15786
],
[
15786,
46,
868
]
],
[
[
843,
7,
3771
],
[
3771,
... | [
[
[
"Tetrabenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Tetrabenazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"... | Tetrabenazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Vemurafenib (Compound)
Tetrabenazine (Compound) downregulates TCTN1 (Gene) and TCTN1 (Gene) is upregulated by Vemurafenib (Compound)
Tetrabenazine (Compound) upregulates SUV39H1 (Gene) and SUV39H1 (Gene) is downregulated by Vemurafenib (Compound... |
DB00531 | DB09074 | 450 | 1,362 | [
"DDInter456",
"DDInter1327"
] | Cyclophosphamide | Olaparib | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
450,
24,
1362
]
],
[
[
450,
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],
[
896,
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[
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450,
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139
],
[
139,
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1362
]
],
[
[
450,
24,
385
],
[
385,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine an... |
DB09237 | DB11837 | 1,586 | 1,297 | [
"DDInter1045",
"DDInter1351"
] | Levamlodipine | Osilodrostat | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1586,
24,
1297
]
],
[
[
1586,
23,
466
],
[
466,
62,
1297
]
],
[
[
1586,
62,
578
],
[
578,
24,
1297
]
],
[
[
1586,
63,
401
],
[
401,
... | [
[
[
"Levamlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Levamlodipine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
... | Levamlodipine may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Levamlodipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor and ... |
DB00365 | DB01087 | 839 | 1,520 | [
"DDInter842",
"DDInter1520"
] | Grepafloxacin | Primaquine | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Major | 2 | [
[
[
839,
25,
1520
]
],
[
[
839,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
839,
23,
112
],
[
112,
23,
1520
]
],
[
[
839,
25,
1342
],
[
1342,
... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
"Hydroxychlo... | Grepafloxacin may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole... |
DB06702 | DB11730 | 573 | 351 | [
"DDInter731",
"DDInter1588"
] | Fesoterodine | Ribociclib | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
573,
24,
351
]
],
[
[
573,
24,
283
],
[
283,
62,
351
]
],
[
[
573,
63,
597
],
[
597,
24,
351
]
],
[
[
573,
24,
98
],
[
98,
24,
... | [
[
[
"Fesoterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Fesoterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
... | Fesoterodine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Fesoterodine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and... |
DB00238 | DB00398 | 188 | 79 | [
"DDInter1285",
"DDInter1702"
] | Nevirapine | Sorafenib | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Moderate | 1 | [
[
[
188,
24,
79
]
],
[
[
188,
6,
6017
],
[
6017,
45,
79
]
],
[
[
188,
21,
29402
],
[
29402,
60,
79
]
],
[
[
188,
24,
1135
],
[
1135,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
]
],
[
[
"Nevirapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Nevirapine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sorafenib (Compound)
Nevirapine (Compound) causes Hepatobiliary disease (Side Effect) and Hepatobiliary disease (Side Effect) is caused by Sorafenib (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB11760 | DB14409 | 119 | 1,129 | [
"DDInter1742",
"DDInter867"
] | Talazoparib | Human adenovirus e serotype 4 strain cl-68578 antigen | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
119,
24,
1129
]
],
[
[
119,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
119,
63,
1683
],
[
1683,
24,
1129
]
],
[
[
119,
24,
738
],
[
738,
... | [
[
[
"Talazoparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Talazoparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Talazoparib may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Talazoparib may cause a moderate interaction that could exacerbate diseases when ta... |
DB00444 | DB06448 | 63 | 171 | [
"DDInter1765",
"DDInter1087"
] | Teniposide | Lonafarnib | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Moderate | 1 | [
[
[
63,
24,
171
]
],
[
[
63,
24,
112
],
[
112,
24,
171
]
],
[
[
63,
24,
310
],
[
310,
63,
171
]
],
[
[
63,
64,
1064
],
[
1064,
24,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lonafarnib"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and... |
DB01018 | DB12267 | 1,364 | 1,476 | [
"DDInter847",
"DDInter233"
] | Guanfacine | Brigatinib | Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approva... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
1364,
24,
1476
]
],
[
[
1364,
24,
951
],
[
951,
24,
1476
]
],
[
[
1364,
63,
530
],
[
530,
24,
1476
]
],
[
[
1364,
24,
982
],
[
982,
... | [
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Guanfacine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
],
[
... | Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Guanfacine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dron... |
DB00747 | DB01267 | 1,442 | 519 | [
"DDInter1647",
"DDInter1381"
] | Scopolamine | Paliperidone | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
1442,
24,
519
]
],
[
[
1442,
63,
1664
],
[
1664,
1,
519
]
],
[
[
1442,
24,
924
],
[
924,
1,
519
]
],
[
[
1442,
21,
28898
],
[
28898,
... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone and Iloperidone (Compound) resembles Paliperidone (... |
DB00682 | DB10897 | 126 | 539 | [
"DDInter1951",
"DDInter291"
] | Warfarin | Capsicum | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Capsicum (Chili pepper) allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
126,
23,
539
]
],
[
[
126,
24,
885
],
[
885,
23,
539
]
],
[
[
126,
63,
1018
],
[
1018,
23,
539
]
],
[
[
126,
25,
1226
],
[
1226,
... | [
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
"E... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Capsicum
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticlopidi... |
DB06702 | DB08897 | 573 | 1,429 | [
"DDInter731",
"DDInter22"
] | Fesoterodine | Aclidinium | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Moderate | 1 | [
[
[
573,
24,
1429
]
],
[
[
573,
63,
352
],
[
352,
24,
1429
]
],
[
[
573,
6,
4304
],
[
4304,
45,
1429
]
],
[
[
573,
21,
28847
],
[
28847,
... | [
[
[
"Fesoterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aclidinium"
]
],
[
[
"Fesoterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trospium"
],
[
... | Fesoterodine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium
Fesoterodine (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Aclidinium (Compound)
Fesoterodine (Compou... |
DB01206 | DB15091 | 37 | 676 | [
"DDInter1086",
"DDInter1901"
] | Lomustine | Upadacitinib | An alkylating agent of value against both hematologic malignancies and solid tumors. | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
37,
25,
676
]
],
[
[
37,
63,
1461
],
[
1461,
23,
676
]
],
[
[
37,
24,
1430
],
[
1430,
24,
676
]
],
[
[
37,
63,
563
],
[
563,
24,... | [
[
[
"Lomustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",... | Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleuc... |
DB01225 | DB11312 | 500 | 298 | [
"DDInter645",
"DDInter1542"
] | Enoxaparin | Protein C | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade. Protein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. It is converted by the thrombin/thrombomodulin-complex on the e... | Moderate | 1 | [
[
[
500,
24,
298
]
],
[
[
500,
25,
707
],
[
707,
24,
298
]
],
[
[
500,
24,
321
],
[
321,
63,
298
]
],
[
[
500,
64,
582
],
[
582,
24,... | [
[
[
"Enoxaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protein C"
]
],
[
[
"Enoxaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
],
[
"Danaparoid"... | Enoxaparin may lead to a major life threatening interaction when taken with Danaparoid and Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Protein C
Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib and Selumetinib may cause... |
DB00783 | DB12332 | 1,438 | 1,619 | [
"DDInter679",
"DDInter1626"
] | Estradiol | Rucaparib | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1438,
24,
1619
]
],
[
[
1438,
24,
112
],
[
112,
23,
1619
]
],
[
[
1438,
63,
1419
],
[
1419,
24,
1619
]
],
[
[
1438,
24,
1213
],
[
1213... | [
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatini... |
DB00227 | DB01177 | 1,463 | 77 | [
"DDInter1098",
"DDInter904"
] | Lovastatin | Idarubicin | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1463,
24,
77
]
],
[
[
1463,
6,
6017
],
[
6017,
45,
77
]
],
[
[
1463,
7,
2903
],
[
2903,
46,
77
]
],
[
[
1463,
18,
4783
],
[
4783,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Lovastatin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",... | Lovastatin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Lovastatin (Compound) upregulates MMP1 (Gene) and MMP1 (Gene) is upregulated by Idarubicin (Compound)
Lovastatin (Compound) downregulates SERPINE1 (Gene) and SERPINE1 (Gene) is upregulated by Idarubicin (Compound)
Lovastatin (... |
DB04844 | DB09104 | 843 | 286 | [
"DDInter1778",
"DDInter1118"
] | Tetrabenazine | Magnesium hydroxide | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
843,
24,
286
]
],
[
[
843,
64,
820
],
[
820,
23,
286
]
],
[
[
843,
63,
1559
],
[
1559,
23,
286
]
],
[
[
843,
63,
688
],
[
688,
2... | [
[
[
"Tetrabenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Tetrabenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
],
[
... | Tetrabenazine may lead to a major life threatening interaction when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Tetrabenazine may cause a moderate interaction that could exacerbate diseases when taken with Famotidine and Famoti... |
DB00047 | DB06655 | 176 | 5 | [
"DDInter932",
"DDInter1077"
] | Insulin glargine | Liraglutide | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
176,
24,
5
]
],
[
[
176,
23,
1103
],
[
1103,
23,
5
]
],
[
[
176,
24,
743
],
[
743,
23,
5
]
],
[
[
176,
24,
1142
],
[
1142,
24,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Insulin glargine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
... | Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril a... |
DB00841 | DB09045 | 532 | 52 | [
"DDInter577",
"DDInter607"
] | Dobutamine | Dulaglutide | A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
532,
24,
52
]
],
[
[
532,
24,
170
],
[
170,
23,
52
]
],
[
[
532,
63,
73
],
[
73,
24,
52
]
],
[
[
532,
24,
1296
],
[
1296,
63,
... | [
[
[
"Dobutamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Dobutamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
[
... | Dobutamine may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Dobutamine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phen... |
DB00773 | DB08860 | 896 | 788 | [
"DDInter702",
"DDInter1479"
] | Etoposide | Pitavastatin | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
896,
24,
788
]
],
[
[
896,
24,
671
],
[
671,
1,
788
]
],
[
[
896,
24,
700
],
[
700,
40,
788
]
],
[
[
896,
6,
17404
],
[
17404,
4... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastatin (Compound) resembles Pitavastatin (Co... |
DB00215 | DB00877 | 1,230 | 629 | [
"DDInter388",
"DDInter1678"
] | Citalopram | Sirolimus | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1230,
24,
629
]
],
[
[
1230,
6,
4973
],
[
4973,
45,
629
]
],
[
[
1230,
7,
8587
],
[
8587,
57,
629
]
],
[
[
1230,
18,
7623
],
[
7623,
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Citalopram (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Citalopram (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is downregulated by Sirolimus (Compound)
Citalopram (Compound) downregulates RRP12 (Gene) and RRP12 (Gene) is downregulated by Sirolimus (Compound)
Citalopram (Compoun... |
DB00434 | DB14740 | 13 | 771 | [
"DDInter459",
"DDInter881"
] | Cyproheptadine | Hyaluronidase | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
13,
23,
771
]
],
[
[
13,
24,
849
],
[
849,
23,
771
]
],
[
[
13,
63,
1242
],
[
1242,
23,
771
]
],
[
[
13,
24,
849
],
[
849,
24,
... | [
[
[
"Cyproheptadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine a... |
DB05316 | DB06616 | 749 | 594 | [
"DDInter1467",
"DDInter224"
] | Pimavanserin | Bosutinib | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
749,
24,
594
]
],
[
[
749,
62,
112
],
[
112,
23,
594
]
],
[
[
749,
63,
1559
],
[
1559,
24,
594
]
],
[
[
749,
24,
1040
],
[
1040,
... | [
[
[
"Pimavanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Pimavanserin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Pimavanserin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Bosutinib
Pimavanserin may cause a moderate interaction that could exacerbate diseases when taken with Famotidine and F... |
DB00443 | DB00812 | 251 | 998 | [
"DDInter195",
"DDInter1451"
] | Betamethasone | Phenylbutazone | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Moderate | 1 | [
[
[
251,
24,
998
]
],
[
[
251,
23,
307
],
[
307,
1,
998
]
],
[
[
251,
63,
362
],
[
362,
1,
998
]
],
[
[
251,
24,
97
],
[
97,
40,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
]
],
[
[
"Betamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
... | Betamethasone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Phenylbutazone (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenylbutazone (Co... |
DB00022 | DB06674 | 268 | 908 | [
"DDInter1408",
"DDInter837"
] | Peginterferon alfa-2b | Golimumab | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
268,
24,
908
]
],
[
[
268,
24,
505
],
[
505,
63,
908
]
],
[
[
268,
24,
458
],
[
458,
24,
908
]
],
[
[
268,
25,
1477
],
[
1477,
2... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodo... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline and Diiodohydroxyquinoline may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate d... |
DB01224 | DB12010 | 623 | 214 | [
"DDInter1553",
"DDInter785"
] | Quetiapine | Fostamatinib | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
623,
24,
214
]
],
[
[
623,
63,
723
],
[
723,
24,
214
]
],
[
[
623,
24,
1250
],
[
1250,
24,
214
]
],
[
[
623,
64,
1166
],
[
1166,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib and Pazop... |
DB00557 | DB09293 | 252 | 116 | [
"DDInter895",
"DDInter954"
] | Hydroxyzine | Iodide I-131 | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
252,
24,
116
]
],
[
[
252,
74,
701
],
[
701,
24,
116
]
],
[
[
252,
25,
1487
],
[
1487,
24,
116
]
],
[
[
252,
24,
516
],
[
516,
2... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Hydroxyzine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when tak... | Hydroxyzine (Compound) resembles Clemastine (Compound) and Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Hydroxyzine may lead to a major life threatening i... |
DB04948 | DB09078 | 1,084 | 1,228 | [
"DDInter1083",
"DDInter1036"
] | Lofexidine | Lenvatinib | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
1084,
24,
1228
]
],
[
[
1084,
62,
112
],
[
112,
23,
1228
]
],
[
[
1084,
63,
609
],
[
609,
24,
1228
]
],
[
[
1084,
24,
603
],
[
603,
... | [
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Lofexidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Lofexidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and ... |
DB12332 | DB12457 | 1,619 | 1,180 | [
"DDInter1626",
"DDInter1598"
] | Rucaparib | Rimegepant | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals. It received FDA approval on February 27, 2020 for the acute treatment migraine headache, and was subsequently approved by the European Commission in April 2022 for both the treatment and prevention of migraines. While several p... | Moderate | 1 | [
[
[
1619,
24,
1180
]
],
[
[
1619,
63,
1419
],
[
1419,
24,
1180
]
],
[
[
1619,
24,
1501
],
[
1501,
63,
1180
]
],
[
[
1619,
64,
351
],
[
351... | [
[
[
"Rucaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rimegepant"
]
],
[
[
"Rucaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[
... | Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Rimegepant
Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Enasidenib and Enasidenib m... |
DB00065 | DB01033 | 581 | 328 | [
"DDInter923",
"DDInter1156"
] | Infliximab | Mercaptopurine | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Major | 2 | [
[
[
581,
25,
328
]
],
[
[
581,
25,
663
],
[
663,
23,
328
]
],
[
[
581,
24,
126
],
[
126,
24,
328
]
],
[
[
581,
24,
1627
],
[
1627,
6... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mercaptopurine"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methotrexate"
],
[
"Methotrexate",
... | Infliximab may lead to a major life threatening interaction when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may caus... |
DB04868 | DB11642 | 478 | 938 | [
"DDInter1293",
"DDInter1480"
] | Nilotinib | Pitolisant | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Major | 2 | [
[
[
478,
25,
938
]
],
[
[
478,
62,
112
],
[
112,
23,
938
]
],
[
[
478,
25,
760
],
[
760,
24,
938
]
],
[
[
478,
24,
28
],
[
28,
24,
... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pitolisant"
]
],
[
[
"Nilotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazo... | Nilotinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Nilotinib may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may cause ... |
DB00624 | DB11730 | 1,561 | 351 | [
"DDInter1775",
"DDInter1588"
] | Testosterone | Ribociclib | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
1561,
24,
351
]
],
[
[
1561,
24,
283
],
[
283,
62,
351
]
],
[
[
1561,
24,
372
],
[
372,
24,
351
]
],
[
[
1561,
63,
663
],
[
663,
... | [
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
... | Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clo... |
DB01138 | DB01229 | 804 | 973 | [
"DDInter1726",
"DDInter1378"
] | Sulfinpyrazone | Paclitaxel (protein-bound) | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
804,
24,
973
]
],
[
[
804,
24,
310
],
[
310,
63,
973
]
],
[
[
804,
6,
8374
],
[
8374,
45,
973
]
],
[
[
804,
7,
16703
],
[
16703,
... | [
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],... | Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
... |
DB00398 | DB08916 | 79 | 26 | [
"DDInter1702",
"DDInter32"
] | Sorafenib | Afatinib | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
79,
24,
26
]
],
[
[
79,
6,
4973
],
[
4973,
45,
26
]
],
[
[
79,
7,
8386
],
[
8386,
46,
26
]
],
[
[
79,
18,
2942
],
[
2942,
46,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Sorafenib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Sorafenib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Afatinib (Compound)
Sorafenib (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Afatinib (Compound)
Sorafenib (Compound) downregulates KEAP1 (Gene) and KEAP1 (Gene) is upregulated by Afatinib (Compound)
Sorafenib (Compound) down... |
DB00529 | DB09156 | 789 | 777 | [
"DDInter779",
"DDInter964"
] | Foscarnet | Iopromide | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Major | 2 | [
[
[
789,
25,
777
]
],
[
[
789,
24,
372
],
[
372,
25,
777
]
],
[
[
789,
25,
1132
],
[
1132,
25,
777
]
],
[
[
789,
63,
589
],
[
589,
2... | [
[
[
"Foscarnet",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iopromide"
]
],
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[
"Clofarabine"... | Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may lead to a major life threatening interaction when taken with Iopromide
Foscarnet may lead to a major life threatening interaction when taken with Gentamicin and Gentamicin may lead to a major life t... |
DB00574 | DB09068 | 121 | 1,427 | [
"DDInter717",
"DDInter1948"
] | Fenfluramine | Vortioxetine | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Major | 2 | [
[
[
121,
25,
1427
]
],
[
[
121,
63,
25
],
[
25,
24,
1427
]
],
[
[
121,
24,
256
],
[
256,
24,
1427
]
],
[
[
121,
24,
405
],
[
405,
63... | [
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vortioxetine"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anistreplase"
],
[
"An... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Prasugrel a... |
DB00682 | DB01381 | 126 | 958 | [
"DDInter1951",
"DDInter819"
] | Warfarin | Ginkgo biloba | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
126,
24,
958
]
],
[
[
126,
25,
1347
],
[
1347,
24,
958
]
],
[
[
126,
24,
1317
],
[
1317,
24,
958
]
],
[
[
126,
63,
121
],
[
121,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clopidogrel"
],
[
"Clopidogre... | Warfarin may lead to a major life threatening interaction when taken with Clopidogrel and Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole and Dipyridamole may c... |
DB00200 | DB01169 | 204 | 57 | [
"DDInter891",
"DDInter120"
] | Hydroxocobalamin | Arsenic trioxide | Hydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is an injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency. It is also used in cyanide poisoning, Leber's optic atrophy, and toxic amblyopia. | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Moderate | 1 | [
[
[
204,
24,
57
]
],
[
[
204,
40,
227
],
[
227,
24,
57
]
],
[
[
204,
6,
4182
],
[
4182,
39,
2084
],
[
2084,
45,
57
]
],
[
[
204,
40,... | [
[
[
"Hydroxocobalamin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Hydroxocobalamin",
"{u} (Compound) resembles {v} (Compound)",
"Cyanocobalamin"
],
[
"Cyanocobalamin",
... | Hydroxocobalamin (Compound) resembles Cyanocobalamin (Compound) and Cyanocobalamin may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide
Hydroxocobalamin (Compound) binds CASP9 (Gene) and CASP9 (Gene) interacts with AKT1 (Gene) and AKT1 (Gene) is bound by Arsenic trioxide (Com... |
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