drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB08882 | DB11979 | 1,281 | 1,320 | [
"DDInter1070",
"DDInter625"
] | Linagliptin | Elagolix | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin w... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1281,
24,
1320
]
],
[
[
1281,
63,
168
],
[
168,
23,
1320
]
],
[
[
1281,
63,
1249
],
[
1249,
24,
1320
]
],
[
[
1281,
24,
129
],
[
129,
... | [
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin... |
DB04865 | DB09276 | 4 | 381 | [
"DDInter1335",
"DDInter1682"
] | Omacetaxine mepesuccinate | Sodium aurothiomalate | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
4,
24,
381
]
],
[
[
4,
24,
1683
],
[
1683,
24,
381
]
],
[
[
4,
63,
491
],
[
491,
24,
381
]
],
[
[
4,
25,
1047
],
[
1047,
24,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate dis... |
DB00450 | DB01611 | 78 | 1,487 | [
"DDInter603",
"DDInter893"
] | Droperidol | Hydroxychloroquine | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
78,
25,
1487
]
],
[
[
78,
25,
1520
],
[
1520,
25,
1487
]
],
[
[
78,
21,
28640
],
[
28640,
60,
1487
]
],
[
[
78,
24,
286
],
[
286,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
],
[
"Primaquine",
... | Droperidol may lead to a major life threatening interaction when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Droperidol (Compound) causes Depression (Side Effect) and Depression (Side Effect) is caused by Hydroxychloroquine (Compound)
Droperid... |
DB01221 | DB01233 | 1,190 | 1,311 | [
"DDInter1007",
"DDInter1197"
] | Ketamine | Metoclopramide | Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
1190,
24,
1311
]
],
[
[
1190,
6,
2250
],
[
2250,
45,
1311
]
],
[
[
1190,
21,
28680
],
[
28680,
60,
1311
]
],
[
[
1190,
24,
649
],
[
64... | [
[
[
"Ketamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Ketamine",
"{u} (Compound) binds {v} (Gene)",
"DRD2"
],
[
"DRD2",
"{u} (Gene) is bound by {v} (Compound)",
... | Ketamine (Compound) binds DRD2 (Gene) and DRD2 (Gene) is bound by Metoclopramide (Compound)
Ketamine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Metoclopramide (Compound)
Ketamine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may c... |
DB00629 | DB11827 | 390 | 433 | [
"DDInter844",
"DDInter669"
] | Guanabenz | Ertugliflozin | An alpha-2 selective adrenergic agonist used as an antihypertensive agent. [PubChem] | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
390,
24,
433
]
],
[
[
390,
63,
251
],
[
251,
24,
433
]
],
[
[
390,
24,
870
],
[
870,
24,
433
]
],
[
[
390,
1,
1364
],
[
1364,
24... | [
[
[
"Guanabenz",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Guanabenz",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
],
... | Guanabenz may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Guanabenz may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortison... |
DB09570 | DB12834 | 1,480 | 148 | [
"DDInter1002",
"DDInter1649"
] | Ixazomib | Secnidazole | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
1480,
24,
148
]
],
[
[
1480,
63,
1593
],
[
1593,
24,
148
]
],
[
[
1480,
24,
1434
],
[
1434,
24,
148
]
],
[
[
1480,
64,
1510
],
[
1510,... | [
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[
... | Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole and Benznid... |
DB00668 | DB06288 | 874 | 607 | [
"DDInter652",
"DDInter77"
] | Epinephrine | Amisulpride | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Moderate | 1 | [
[
[
874,
24,
607
]
],
[
[
874,
21,
28722
],
[
28722,
60,
607
]
],
[
[
874,
24,
144
],
[
144,
63,
607
]
],
[
[
874,
24,
480
],
[
480,
... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amisulpride"
]
],
[
[
"Epinephrine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused ... | Epinephrine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Amisulpride (Compound)
Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Amisulprid... |
DB00682 | DB06441 | 126 | 936 | [
"DDInter1951",
"DDInter283"
] | Warfarin | Cangrelor | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Major | 2 | [
[
[
126,
25,
936
]
],
[
[
126,
23,
1631
],
[
1631,
62,
936
]
],
[
[
126,
36,
97
],
[
97,
24,
936
]
],
[
[
126,
25,
1171
],
[
1171,
2... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cangrelor"
]
],
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
],
[
"Turmeric",
"{... | Warfarin may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor interaction that can limit clinical effects when taken with Cangrelor
Warfarin (Compound) resembles Oxaprozin (Compound) and Warfarin may lead to a major life threatening interaction when taken... |
DB00214 | DB00762 | 1,028 | 613 | [
"DDInter1836",
"DDInter973"
] | Torasemide | Irinotecan | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Moderate | 1 | [
[
[
1028,
24,
613
]
],
[
[
1028,
18,
3439
],
[
3439,
46,
613
]
],
[
[
1028,
21,
28645
],
[
28645,
60,
613
]
],
[
[
1028,
63,
600
],
[
600,... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
]
],
[
[
"Torasemide",
"{u} (Compound) downregulates {v} (Gene)",
"GRN"
],
[
"GRN",
"{u} (Gene) is upregulated by {v} (Com... | Torasemide (Compound) downregulates GRN (Gene) and GRN (Gene) is upregulated by Irinotecan (Compound)
Torasemide (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Irinotecan (Compound)
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Flu... |
DB00862 | DB08907 | 1,005 | 1,344 | [
"DDInter1918",
"DDInter280"
] | Vardenafil | Canagliflozin | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1005,
24,
1344
]
],
[
[
1005,
24,
549
],
[
549,
1,
1344
]
],
[
[
1005,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
1005,
21,
28681
],
[
28681... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Vardenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Vardenafil (Compound) causes Hypersensitivity (Side Ef... |
DB00572 | DB03128 | 85 | 140 | [
"DDInter136",
"DDInter18"
] | Atropine | Acetylcholine | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken ... | Moderate | 1 | [
[
[
85,
24,
140
]
],
[
[
85,
24,
1376
],
[
1376,
24,
140
]
],
[
[
85,
63,
999
],
[
999,
24,
140
]
],
[
[
85,
24,
1116
],
[
1116,
63,... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylcholine"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Acetylcholine
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylpera... |
DB01144 | DB06655 | 1,326 | 5 | [
"DDInter540",
"DDInter1077"
] | Diclofenamide | Liraglutide | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
1326,
24,
5
]
],
[
[
1326,
63,
870
],
[
870,
24,
5
]
],
[
[
1326,
24,
708
],
[
708,
24,
5
]
],
[
[
1326,
24,
1019
],
[
1019,
63,... | [
[
[
"Diclofenamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Diclofenamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
... | Diclofenamide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Diclofenamide may cause a moderate interaction that could exacerbate diseases when taken with Cort... |
DB01087 | DB01218 | 1,520 | 1,493 | [
"DDInter1520",
"DDInter852"
] | Primaquine | Halofantrine | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
1520,
25,
1493
]
],
[
[
1520,
6,
12523
],
[
12523,
45,
1493
]
],
[
[
1520,
21,
29119
],
[
29119,
60,
1493
]
],
[
[
1520,
62,
211
],
[
... | [
[
[
"Primaquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Primaquine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Halof... | Primaquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Halofantrine (Compound)
Primaquine (Compound) causes Haemolytic anaemia (Side Effect) and Haemolytic anaemia (Side Effect) is caused by Halofantrine (Compound)
Primaquine may cause a minor interaction that can limit clinical effects when taken with... |
DB01075 | DB04844 | 1,376 | 843 | [
"DDInter569",
"DDInter1778"
] | Diphenhydramine | Tetrabenazine | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Moderate | 1 | [
[
[
1376,
24,
843
]
],
[
[
1376,
63,
479
],
[
479,
40,
843
]
],
[
[
1376,
6,
12523
],
[
12523,
45,
843
]
],
[
[
1376,
21,
28698
],
[
28698... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
... | Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil (Compound) resembles Tetrabenazine (Compound)
Diphenhydramine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tetrabenazine (Compound)
Diphenhydramine (Compound) causes Insomnia (Side Eff... |
DB01611 | DB06636 | 1,487 | 1,623 | [
"DDInter893",
"DDInter980"
] | Hydroxychloroquine | Isavuconazonium | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
1487,
24,
1623
]
],
[
[
1487,
63,
1419
],
[
1419,
24,
1623
]
],
[
[
1487,
64,
1557
],
[
1557,
24,
1623
]
],
[
[
1487,
24,
309
],
[
309... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatin... | Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Hydroxychloroquine may lead to a major life threatening interaction when taken with Astemizole and Aste... |
DB00281 | DB01199 | 608 | 1,217 | [
"DDInter1066",
"DDInter1890"
] | Lidocaine | Tubocurarine | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to coat the tips of hunting arrows and darts, which were typically derived from plants of the genera _Chondrodend... | Moderate | 1 | [
[
[
608,
24,
1217
]
],
[
[
608,
24,
545
],
[
545,
1,
1217
]
],
[
[
608,
23,
1220
],
[
1220,
63,
1217
]
],
[
[
608,
23,
1448
],
[
1448,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tubocurarine"
]
],
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metocurine"
],
[
... | Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Metocurine and Metocurine (Compound) resembles Tubocurarine (Compound)
Lidocaine may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone may cause a moderate interaction that c... |
DB00283 | DB00836 | 701 | 543 | [
"DDInter395",
"DDInter1088"
] | Clemastine | Loperamide | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
701,
24,
543
]
],
[
[
701,
24,
704
],
[
704,
40,
543
]
],
[
[
701,
25,
675
],
[
675,
24,
543
]
],
[
[
701,
24,
649
],
[
649,
1,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Loperamide (Compound)
Clemastine may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene may cause a moderate interaction that could ex... |
DB00030 | DB00254 | 1,685 | 964 | [
"DDInter934",
"DDInter598"
] | Insulin human | Doxycycline | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Moderate | 1 | [
[
[
1685,
24,
964
]
],
[
[
1685,
24,
1572
],
[
1572,
40,
964
]
],
[
[
1685,
24,
1620
],
[
1620,
1,
964
]
],
[
[
1685,
24,
1399
],
[
1399,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxycycline"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Doxycycline (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline and Tetracycline (Compound) resembles Dox... |
DB00862 | DB09082 | 1,005 | 659 | [
"DDInter1918",
"DDInter1934"
] | Vardenafil | Vilanterol | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1005,
24,
659
]
],
[
[
1005,
24,
927
],
[
927,
63,
659
]
],
[
[
1005,
25,
1069
],
[
1069,
24,
659
]
],
[
[
1005,
24,
1450
],
[
1450,
... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[
... | Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Vardenafil may lead to a major life threatening interaction when taken with Vandetanib and Vandetanib may caus... |
DB00836 | DB12245 | 543 | 823 | [
"DDInter1088",
"DDInter1863"
] | Loperamide | Triclabendazole | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
543,
24,
823
]
],
[
[
543,
24,
112
],
[
112,
23,
823
]
],
[
[
543,
24,
1612
],
[
1612,
24,
823
]
],
[
[
543,
63,
1010
],
[
1010,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir ... |
DB00556 | DB11901 | 1,262 | 913 | [
"DDInter1429",
"DDInter107"
] | Perflutren | Apalutamide | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1262,
24,
913
]
],
[
[
1262,
23,
112
],
[
112,
23,
913
]
],
[
[
1262,
63,
600
],
[
600,
24,
913
]
],
[
[
1262,
24,
28
],
[
28,
2... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Perflutren",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Perflutren may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Perflutren may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fl... |
DB00092 | DB00443 | 58 | 251 | [
"DDInter40",
"DDInter195"
] | Alefacept | Betamethasone | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Moderate | 1 | [
[
[
58,
24,
251
]
],
[
[
58,
24,
617
],
[
617,
40,
251
]
],
[
[
58,
24,
870
],
[
870,
1,
251
]
],
[
[
58,
23,
1461
],
[
1461,
23,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Betamethasone (Compound)
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Betamethaso... |
DB11793 | DB12332 | 738 | 1,619 | [
"DDInter1297",
"DDInter1626"
] | Niraparib | Rucaparib | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
738,
24,
1619
]
],
[
[
738,
63,
259
],
[
259,
24,
1619
]
],
[
[
738,
24,
151
],
[
151,
63,
1619
]
],
[
[
738,
24,
710
],
[
710,
... | [
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
[
... | Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/Cali... |
DB00366 | DB04908 | 1,594 | 1,671 | [
"DDInter600",
"DDInter741"
] | Doxylamine | Flibanserin | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
1594,
24,
1671
]
],
[
[
1594,
24,
830
],
[
830,
24,
1671
]
],
[
[
1594,
24,
407
],
[
407,
63,
1671
]
],
[
[
1594,
63,
1242
],
[
1242,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
],
[... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium ... |
DB09074 | DB14711 | 1,362 | 779 | [
"DDInter1327",
"DDInter1680"
] | Olaparib | Smallpox (Vaccinia) Vaccine, Live | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
1362,
25,
779
]
],
[
[
1362,
64,
1064
],
[
1064,
25,
779
]
],
[
[
1362,
63,
478
],
[
478,
25,
779
]
],
[
[
1362,
25,
1259
],
[
1259,
... | [
[
[
"Olaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Olaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cladri... | Olaparib may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may lead... |
DB01190 | DB04834 | 568 | 276 | [
"DDInter398",
"DDInter1571"
] | Clindamycin | Rapacuronium | Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bac... | Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm. | Moderate | 1 | [
[
[
568,
24,
276
]
],
[
[
568,
63,
1132
],
[
1132,
25,
276
]
],
[
[
568,
6,
8374
],
[
8374,
45,
613
],
[
613,
23,
276
]
],
[
[
568,
... | [
[
[
"Clindamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rapacuronium"
]
],
[
[
"Clindamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gentamicin"
],
... | Clindamycin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin and Gentamicin may lead to a major life threatening interaction when taken with Rapacuronium
Clindamycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Irinotecan (Compound) and Irinotecan may cause a mi... |
DB00039 | DB00552 | 1,253 | 1,238 | [
"DDInter1380",
"DDInter1425"
] | Palifermin | Pentostatin | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Moderate | 1 | [
[
[
1253,
24,
1238
]
],
[
[
1253,
24,
1426
],
[
1426,
1,
1238
]
],
[
[
1253,
24,
1648
],
[
1648,
24,
1238
]
],
[
[
1253,
24,
995
],
[
995,... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentostatin"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azacitidine"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Azacitidine and Azacitidine (Compound) resembles Pentostatin (Compound)
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that ... |
DB00213 | DB12615 | 837 | 1,381 | [
"DDInter1388",
"DDInter1482"
] | Pantoprazole | Plazomicin | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from . The structure of plazomicin was established via appending hydroxylaminobutyric acid to at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglyco... | Moderate | 1 | [
[
[
837,
24,
1381
]
],
[
[
837,
23,
1479
],
[
1479,
24,
1381
]
],
[
[
837,
24,
416
],
[
416,
24,
1381
]
],
[
[
837,
1,
379
],
[
379,
... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Plazomicin"
]
],
[
[
"Pantoprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetylsalicylic acid"
... | Pantoprazole may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Plazomicin
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00048 | DB11095 | 1,595 | 235 | [
"DDInter435",
"DDInter505"
] | Collagenase clostridium histolyticum | Desirudin | Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Moderate | 1 | [
[
[
1595,
24,
235
]
],
[
[
1595,
24,
578
],
[
578,
24,
235
]
],
[
[
1595,
24,
1409
],
[
1409,
25,
235
]
],
[
[
1595,
63,
1271
],
[
1271,
... | [
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desirudin"
]
],
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when ... | Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Collagenase clostridium histolyticum may cause a moderate interaction that could exacer... |
DB00108 | DB06650 | 1,066 | 1,500 | [
"DDInter1268",
"DDInter1324"
] | Natalizumab | Ofatumumab | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however... | Major | 2 | [
[
[
1066,
25,
1500
]
],
[
[
1066,
25,
270
],
[
270,
63,
1500
]
],
[
[
1066,
24,
1129
],
[
1129,
63,
1500
]
],
[
[
1066,
25,
869
],
[
869,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ofatumumab"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ocrelizumab"
],
[
"Ocrelizumab",
"{... | Natalizumab may lead to a major life threatening interaction when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Ofatumumab
Natalizumab may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 st... |
DB00477 | DB09020 | 216 | 28 | [
"DDInter363",
"DDInter212"
] | Chlorpromazine | Bisacodyl | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
216,
24,
28
]
],
[
[
216,
24,
662
],
[
662,
1,
28
]
],
[
[
216,
63,
128
],
[
128,
40,
28
]
],
[
[
216,
35,
272
],
[
272,
40,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
]... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Bisacodyl (Compound)
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine (Compound) res... |
DB00775 | DB06605 | 1,226 | 1,409 | [
"DDInter1818",
"DDInter108"
] | Tirofiban | Apixaban | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
1226,
25,
1409
]
],
[
[
1226,
21,
28931
],
[
28931,
60,
1409
]
],
[
[
1226,
23,
539
],
[
539,
62,
1409
]
],
[
[
1226,
63,
109
],
[
109... | [
[
[
"Tirofiban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Tirofiban",
"{u} (Compound) causes {v} (Side Effect)",
"Haemorrhage"
],
[
"Haemorrhage",
"{u} (Side Effect) is caused by {v} (Comp... | Tirofiban (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Apixaban (Compound)
Tirofiban may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Apixaban
Tirofi... |
DB08932 | DB09065 | 1,398 | 760 | [
"DDInter1111",
"DDInter424"
] | Macitentan | Cobicistat | Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension. It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
1398,
25,
760
]
],
[
[
1398,
63,
1101
],
[
1101,
23,
760
]
],
[
[
1398,
63,
723
],
[
723,
24,
760
]
],
[
[
1398,
64,
609
],
[
609,
... | [
[
[
"Macitentan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Macitentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarotene... | Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepita... |
DB00286 | DB00414 | 380 | 590 | [
"DDInter439",
"DDInter16"
] | Conjugated estrogens | Acetohexamide | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Moderate | 1 | [
[
[
380,
24,
590
]
],
[
[
380,
24,
1017
],
[
1017,
63,
590
]
],
[
[
380,
40,
1438
],
[
1438,
63,
590
]
],
[
[
380,
63,
176
],
[
176,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorl... | Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide
Conjugated estrogens (Compound) resembles Estradiol (Compound) and Estradiol may cause a moderate i... |
DB00609 | DB01309 | 595 | 1,254 | [
"DDInter694",
"DDInter933"
] | Ethionamide | Insulin glulisine | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
595,
24,
1254
]
],
[
[
595,
63,
305
],
[
305,
24,
1254
]
],
[
[
595,
24,
850
],
[
850,
63,
1254
]
],
[
[
595,
24,
1411
],
[
1411,
... | [
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Esche... | Ethionamide may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Ethionamide may cause a moderate interaction that could exacerbate... |
DB00633 | DB01176 | 614 | 537 | [
"DDInter520",
"DDInter453"
] | Dexmedetomidine | Cyclizine | An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine. | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
614,
24,
537
]
],
[
[
614,
63,
1242
],
[
1242,
24,
537
]
],
[
[
614,
21,
29054
],
[
29054,
60,
537
]
],
[
[
614,
24,
1532
],
[
1532,
... | [
[
[
"Dexmedetomidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Dexmedetomidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],... | Dexmedetomidine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Dexmedetomidine (Compound) causes Speech disorder (Side Effect) and Speech disorder (Side Effect) is caused ... |
DB00264 | DB00358 | 88 | 1,010 | [
"DDInter1200",
"DDInter1140"
] | Metoprolol | Mefloquine | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Moderate | 1 | [
[
[
88,
24,
1010
]
],
[
[
88,
6,
12523
],
[
12523,
45,
1010
]
],
[
[
88,
21,
28789
],
[
28789,
60,
1010
]
],
[
[
88,
24,
688
],
[
688,
... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
]
],
[
[
"Metoprolol",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",... | Metoprolol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mefloquine (Compound)
Metoprolol (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Mefloquine (Compound)
Metoprolol may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01009 | DB09133 | 935 | 1,527 | [
"DDInter1009",
"DDInter965"
] | Ketoprofen | Iothalamic acid | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Major | 2 | [
[
[
935,
25,
1527
]
],
[
[
935,
1,
1523
],
[
1523,
24,
1527
]
],
[
[
935,
63,
91
],
[
91,
25,
1527
]
],
[
[
935,
24,
848
],
[
848,
2... | [
[
[
"Ketoprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Ketoprofen",
"{u} (Compound) resembles {v} (Compound)",
"Labetalol"
],
[
"Labetalol",
"{u} may cause a moderate interactio... | Ketoprofen (Compound) resembles Labetalol (Compound) and Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may lead to a major life threatening int... |
DB01263 | DB08875 | 859 | 1,618 | [
"DDInter1494",
"DDInter262"
] | Posaconazole | Cabozantinib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
859,
25,
1618
]
],
[
[
859,
25,
1135
],
[
1135,
62,
1618
]
],
[
[
859,
62,
112
],
[
112,
23,
1618
]
],
[
[
859,
63,
723
],
[
723,
... | [
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{... | Posaconazole may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Posaconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may ... |
DB00959 | DB12332 | 1,486 | 1,619 | [
"DDInter1191",
"DDInter1626"
] | Methylprednisolone | Rucaparib | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1486,
24,
1619
]
],
[
[
1486,
62,
307
],
[
307,
23,
1619
]
],
[
[
1486,
24,
259
],
[
259,
24,
1619
]
],
[
[
1486,
24,
151
],
[
151,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Methylprednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
... | Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept a... |
DB00035 | DB14575 | 1,314 | 733 | [
"DDInter507",
"DDInter674"
] | Desmopressin | Eslicarbazepine | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
1314,
24,
733
]
],
[
[
1314,
24,
1264
],
[
1264,
24,
733
]
],
[
[
1314,
24,
1264
],
[
1264,
63,
272
],
[
272,
24,
733
]
],
[
[
1314,
... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
... | Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Eslicarbazepine
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepi... |
DB00832 | DB06691 | 499 | 849 | [
"DDInter1446",
"DDInter1155"
] | Phensuximide | Mepyramine | Phensuximide is a member of the succinimide class with anticonvulsant properties. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
499,
24,
849
]
],
[
[
499,
63,
1594
],
[
1594,
24,
849
]
],
[
[
499,
24,
272
],
[
272,
24,
849
]
],
[
[
499,
7,
2216
],
[
2216,
... | [
[
[
"Phensuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Phensuximide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Phensuximide may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Phensuximide may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine ... |
DB00620 | DB00624 | 175 | 1,561 | [
"DDInter1855",
"DDInter1775"
] | Triamcinolone | Testosterone | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Moderate | 1 | [
[
[
175,
24,
1561
]
],
[
[
175,
63,
443
],
[
443,
1,
1561
]
],
[
[
175,
24,
155
],
[
155,
1,
1561
]
],
[
[
175,
40,
870
],
[
870,
63... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Testosterone"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Spironolactone"
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone and Spironolactone (Compound) resembles Testosterone (Compound)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resemb... |
DB00104 | DB00307 | 966 | 1,101 | [
"DDInter1323",
"DDInter202"
] | Octreotide | Bexarotene | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Major | 2 | [
[
[
966,
25,
1101
]
],
[
[
966,
21,
28762
],
[
28762,
60,
1101
]
],
[
[
966,
24,
608
],
[
608,
23,
1101
]
],
[
[
966,
24,
655
],
[
655,
... | [
[
[
"Octreotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
]
],
[
[
"Octreotide",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by {v} (Compou... | Octreotide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Bexarotene (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Oc... |
DB00193 | DB00771 | 534 | 262 | [
"DDInter1841",
"DDInter397"
] | Tramadol | Clidinium | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Moderate | 1 | [
[
[
534,
24,
262
]
],
[
[
534,
24,
1511
],
[
1511,
63,
262
]
],
[
[
534,
6,
2720
],
[
2720,
45,
262
]
],
[
[
534,
24,
19
],
[
19,
24... | [
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clidinium"
]
],
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Tramadol (Compound) binds CHRM3 (Gene) and CHRM3 (Gene) is bound by Clidinium (Compound)
Tramadol may cause a mod... |
DB01579 | DB09043 | 341 | 135 | [
"DDInter1439",
"DDInter36"
] | Phendimetrazine | Albiglutide | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
341,
24,
135
]
],
[
[
341,
63,
1647
],
[
1647,
23,
135
]
],
[
[
341,
63,
176
],
[
176,
24,
135
]
],
[
[
341,
64,
73
],
[
73,
24,... | [
[
[
"Phendimetrazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Phendimetrazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],... | Phendimetrazine may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Phendimetrazine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine... |
DB00816 | DB00834 | 1,674 | 932 | [
"DDInter1346",
"DDInter1215"
] | Orciprenaline | Mifepristone | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Major | 2 | [
[
[
1674,
25,
932
]
],
[
[
1674,
7,
2384
],
[
2384,
46,
932
]
],
[
[
1674,
21,
28762
],
[
28762,
60,
932
]
],
[
[
1674,
24,
480
],
[
480,
... | [
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mifepristone"
]
],
[
[
"Orciprenaline",
"{u} (Compound) upregulates {v} (Gene)",
"CDK6"
],
[
"CDK6",
"{u} (Gene) is upregulated by {v} (Compound)"... | Orciprenaline (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Mifepristone (Compound)
Orciprenaline (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Mifepristone (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB01166 | DB06441 | 477 | 936 | [
"DDInter379",
"DDInter283"
] | Cilostazol | Cangrelor | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Moderate | 1 | [
[
[
477,
24,
936
]
],
[
[
477,
23,
944
],
[
944,
62,
936
]
],
[
[
477,
63,
97
],
[
97,
24,
936
]
],
[
[
477,
24,
637
],
[
637,
63,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cangrelor"
]
],
[
[
"Cilostazol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
... | Cilostazol may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Cangrelor
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin may ... |
DB00214 | DB01156 | 1,028 | 593 | [
"DDInter1836",
"DDInter252"
] | Torasemide | Bupropion | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Moderate | 1 | [
[
[
1028,
24,
593
]
],
[
[
1028,
6,
3486
],
[
3486,
45,
593
]
],
[
[
1028,
18,
17469
],
[
17469,
57,
593
]
],
[
[
1028,
21,
28757
],
[
287... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
]
],
[
[
"Torasemide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Torasemide (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Bupropion (Compound)
Torasemide (Compound) downregulates ADI1 (Gene) and ADI1 (Gene) is downregulated by Bupropion (Compound)
Torasemide (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Bupropion (Compound)
Torasem... |
DB01278 | DB04575 | 1,021 | 35 | [
"DDInter1506",
"DDInter1555"
] | Pramlintide | Quinestrol | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | The 3-cyclopentyl ether of ethinyl estradiol. | Moderate | 1 | [
[
[
1021,
24,
35
]
],
[
[
1021,
63,
566
],
[
566,
1,
35
]
],
[
[
1021,
24,
984
],
[
984,
40,
35
]
],
[
[
1021,
63,
1336
],
[
1336,
4... | [
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
]
],
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonorgestrel"
],
... | Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel and Levonorgestrel (Compound) resembles Quinestrol (Compound)
Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol (Compound) resembles Quinestrol (Compou... |
DB00687 | DB11110 | 870 | 603 | [
"DDInter747",
"DDInter1115"
] | Fludrocortisone | Magnesium citrate | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
870,
24,
603
]
],
[
[
870,
25,
57
],
[
57,
24,
603
]
],
[
[
870,
63,
789
],
[
789,
24,
603
]
],
[
[
870,
24,
519
],
[
519,
24,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Fludrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
... | Fludrocortisone may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Foscarn... |
DB00647 | DB01001 | 675 | 688 | [
"DDInter528",
"DDInter1632"
] | Dextropropoxyphene | Salbutamol | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
675,
24,
688
]
],
[
[
675,
24,
455
],
[
455,
24,
688
]
],
[
[
675,
24,
1148
],
[
1148,
63,
688
]
],
[
[
675,
6,
8374
],
[
8374,
... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"... | Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Isopr... |
DB00421 | DB11691 | 443 | 1,499 | [
"DDInter1707",
"DDInter1258"
] | Spironolactone | Naldemedine | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Moderate | 1 | [
[
[
443,
24,
1499
]
],
[
[
443,
24,
578
],
[
578,
24,
1499
]
],
[
[
443,
24,
159
],
[
159,
63,
1499
]
],
[
[
443,
25,
1456
],
[
1456,
... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naldemedine"
]
],
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],... | Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectini... |
DB01611 | DB06702 | 1,487 | 573 | [
"DDInter893",
"DDInter731"
] | Hydroxychloroquine | Fesoterodine | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
1487,
24,
573
]
],
[
[
1487,
62,
211
],
[
211,
1,
573
]
],
[
[
1487,
64,
494
],
[
494,
1,
573
]
],
[
[
1487,
6,
12523
],
[
12523,
... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tolterodine... | Hydroxychloroquine may cause a minor interaction that can limit clinical effects when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Hydroxychloroquine may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) resembles Fesoterodine (C... |
DB01404 | DB08816 | 757 | 578 | [
"DDInter820",
"DDInter1802"
] | Ginseng | Ticagrelor | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
757,
24,
578
]
],
[
[
757,
63,
1578
],
[
1578,
24,
578
]
],
[
[
757,
24,
761
],
[
761,
24,
578
]
],
[
[
757,
24,
840
],
[
840,
6... | [
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lepirudin"
],
[
"Le... | Ginseng may cause a moderate interaction that could exacerbate diseases when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor
Ginseng may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and Saxagliptin m... |
DB00331 | DB15305 | 1,645 | 719 | [
"DDInter1164",
"DDInter1603"
] | Metformin | Risdiplam | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Risdiplam is an orally bioavailable mRNA splicing modifier used for the treatment of spinal muscular atrophy (SMA). It increases systemic SMN protein concentrations by improving the efficiency of _SMN2_ gene transcription. This mechanism of action is similar to its predecessor [nusinersen], the biggest difference being... | Moderate | 1 | [
[
[
1645,
24,
719
]
],
[
[
1645,
21,
28792
],
[
28792,
60,
1159
],
[
1159,
24,
719
]
],
[
[
1645,
24,
971
],
[
971,
63,
1159
],
[
1159,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risdiplam"
]
],
[
[
"Metformin",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal disorder"
],
[
"Gastrointestinal disorder",
... | Metformin (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Methylnaltrexone (Compound) and Methylnaltrexone may cause a moderate interaction that could exacerbate diseases when taken with Risdiplam
Metformin may cause a moderate interaction that could ex... |
DB00358 | DB00843 | 1,010 | 479 | [
"DDInter1140",
"DDInter583"
] | Mefloquine | Donepezil | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
1010,
24,
479
]
],
[
[
1010,
24,
843
],
[
843,
1,
479
]
],
[
[
1010,
6,
12523
],
[
12523,
45,
479
]
],
[
[
1010,
18,
2183
],
[
2183,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine and Tetrabenazine (Compound) resembles Donepezil (Compound)
Mefloquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound)
Mefloquine (Compound) downregulates CDC20 (Gene) and CDC20 (Ge... |
DB00334 | DB00738 | 867 | 485 | [
"DDInter1326",
"DDInter1420"
] | Olanzapine | Pentamidine | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Moderate | 1 | [
[
[
867,
24,
485
]
],
[
[
867,
6,
12523
],
[
12523,
45,
485
]
],
[
[
867,
23,
112
],
[
112,
62,
485
]
],
[
[
867,
24,
971
],
[
971,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
]
],
[
[
"Olanzapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)"... | Olanzapine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pentamidine (Compound)
Olanzapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pentamidine
Olanzapine may... |
DB01064 | DB01211 | 1,148 | 609 | [
"DDInter987",
"DDInter393"
] | Isoprenaline | Clarithromycin | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1148,
24,
609
]
],
[
[
1148,
63,
1570
],
[
1570,
24,
609
]
],
[
[
1148,
18,
2183
],
[
2183,
57,
609
]
],
[
[
1148,
21,
28662
],
[
2866... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
]... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Isoprenaline (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Clarithromycin... |
DB09498 | DB13007 | 810 | 1,060 | [
"DDInter1715",
"DDInter642"
] | Strontium chloride Sr-89 | Enfortumab vedotin | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
810,
24,
1060
]
],
[
[
810,
63,
350
],
[
350,
24,
1060
]
],
[
[
810,
24,
1480
],
[
1480,
24,
1060
]
],
[
[
810,
24,
676
],
[
676,
... | [
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib and Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin
Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases... |
DB01059 | DB06595 | 956 | 1,491 | [
"DDInter1313",
"DDInter1214"
] | Norfloxacin | Midostaurin | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
956,
24,
1491
]
],
[
[
956,
62,
112
],
[
112,
23,
1491
]
],
[
[
956,
24,
761
],
[
761,
24,
1491
]
],
[
[
956,
63,
888
],
[
888,
... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Norfloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Norfloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and ... |
DB06168 | DB11714 | 1,531 | 1,316 | [
"DDInter281",
"DDInter610"
] | Canakinumab | Durvalumab | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote... | Moderate | 1 | [
[
[
1531,
24,
1316
]
],
[
[
1531,
62,
1461
],
[
1461,
23,
1316
]
],
[
[
1531,
23,
1114
],
[
1114,
23,
1316
]
],
[
[
1531,
63,
167
],
[
167... | [
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Durvalumab"
]
],
[
[
"Canakinumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Canakinumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Durvalumab
Canakinumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfa... |
DB08880 | DB11986 | 1,510 | 484 | [
"DDInter1771",
"DDInter648"
] | Teriflunomide | Entrectinib | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
1510,
25,
484
]
],
[
[
1510,
63,
112
],
[
112,
23,
484
]
],
[
[
1510,
24,
466
],
[
466,
62,
484
]
],
[
[
1510,
63,
1197
],
[
1197,
... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"... | Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Darolutami... |
DB00877 | DB09061 | 629 | 1,627 | [
"DDInter1678",
"DDInter284"
] | Sirolimus | Cannabidiol | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
629,
24,
1627
]
],
[
[
629,
63,
723
],
[
723,
23,
1627
]
],
[
[
629,
25,
760
],
[
760,
62,
1627
]
],
[
[
629,
25,
609
],
[
609,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Sirolimus may lead to a major life threatening interaction when taken with Cobicistat and Cobicistat may cause a m... |
DB01285 | DB11817 | 708 | 1,259 | [
"DDInter445",
"DDInter165"
] | Corticotropin | Baricitinib | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
708,
25,
1259
]
],
[
[
708,
24,
949
],
[
949,
24,
1259
]
],
[
[
708,
24,
1129
],
[
1129,
63,
1259
]
],
[
[
708,
25,
1011
],
[
1011,
... | [
[
[
"Corticotropin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (... | Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Corticot... |
DB00344 | DB01001 | 1,302 | 688 | [
"DDInter1543",
"DDInter1632"
] | Protriptyline | Salbutamol | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1302,
24,
688
]
],
[
[
1302,
25,
874
],
[
874,
24,
688
]
],
[
[
1302,
24,
455
],
[
455,
24,
688
]
],
[
[
1302,
24,
1148
],
[
1148,
... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Protriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epinephrine"
],
[
"Epi... | Protriptyline may lead to a major life threatening interaction when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol ma... |
DB06589 | DB12010 | 1,250 | 214 | [
"DDInter1400",
"DDInter785"
] | Pazopanib | Fostamatinib | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1250,
24,
214
]
],
[
[
1250,
25,
976
],
[
976,
24,
214
]
],
[
[
1250,
63,
723
],
[
723,
24,
214
]
],
[
[
1250,
24,
861
],
[
861,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitin... | Pazopanib may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may caus... |
DB00280 | DB01069 | 494 | 401 | [
"DDInter575",
"DDInter1533"
] | Disopyramide | Promethazine | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Major | 2 | [
[
[
494,
25,
401
]
],
[
[
494,
25,
1264
],
[
1264,
63,
401
]
],
[
[
494,
40,
649
],
[
649,
63,
401
]
],
[
[
494,
1,
11392
],
[
11392,
... | [
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
]
],
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
],
[
"Doxepin",
"{u} m... | Disopyramide may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Disopyramide (Compound) resembles Clofedanol (Compound) and Clofedanol may cause a moderate interaction that could exacerbate dis... |
DB00950 | DB04908 | 1,413 | 1,671 | [
"DDInter732",
"DDInter741"
] | Fexofenadine | Flibanserin | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
1413,
24,
1671
]
],
[
[
1413,
24,
741
],
[
741,
63,
1671
]
],
[
[
1413,
1,
1242
],
[
1242,
24,
1671
]
],
[
[
1413,
24,
478
],
[
478,
... | [
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
],
... | Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin
Fexofenadine (Compound) resembles Cetirizine (Compound) and Cetirizine may cause a moderate interaction that ... |
DB01115 | DB06273 | 336 | 980 | [
"DDInter1291",
"DDInter1824"
] | Nifedipine | Tocilizumab | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
336,
24,
980
]
],
[
[
336,
40,
1428
],
[
1428,
24,
980
]
],
[
[
336,
24,
309
],
[
309,
24,
980
]
],
[
[
336,
62,
1031
],
[
1031,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Nifedipine",
"{u} (Compound) resembles {v} (Compound)",
"Isradipine"
],
[
"Isradipine",
"{u} may cause a modera... | Nifedipine (Compound) resembles Isradipine (Compound) and Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that co... |
DB00009 | DB00939 | 1,271 | 1,338 | [
"DDInter56",
"DDInter1135"
] | Alteplase | Meclofenamic acid | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Moderate | 1 | [
[
[
1271,
24,
1338
]
],
[
[
1271,
24,
1479
],
[
1479,
63,
1338
]
],
[
[
1271,
24,
1347
],
[
1347,
24,
1338
]
],
[
[
1271,
25,
1226
],
[
12... | [
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid"
]
],
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
... | Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid
Alteplase may cause a moderate interaction that could exacerbate diseases when taken w... |
DB01174 | DB01619 | 697 | 830 | [
"DDInter1442",
"DDInter1441"
] | Phenobarbital | Phenindamine | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
697,
24,
830
]
],
[
[
697,
24,
537
],
[
537,
40,
830
]
],
[
[
697,
63,
1219
],
[
1219,
40,
830
]
],
[
[
697,
63,
13
],
[
13,
24,... | [
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
... | Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine (Compound) resembles Phenindamine (Comp... |
DB00040 | DB00682 | 27 | 126 | [
"DDInter827",
"DDInter1951"
] | Glucagon | Warfarin | Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.[L7634,L7637,L7640,L7643,L8519] Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Minor | 0 | [
[
[
27,
23,
126
]
],
[
[
27,
23,
729
],
[
729,
62,
126
]
],
[
[
27,
23,
1523
],
[
1523,
23,
126
]
],
[
[
27,
24,
831
],
[
831,
25,
... | [
[
[
"Glucagon",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Warfarin"
]
],
[
[
"Glucagon",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Penbutolol"
],
[
"Penbu... | Glucagon may cause a minor interaction that can limit clinical effects when taken with Penbutolol and Penbutolol may cause a minor interaction that can limit clinical effects when taken with Warfarin
Glucagon may cause a minor interaction that can limit clinical effects when taken with Labetalol and Labetalol may cause... |
DB00556 | DB11113 | 1,262 | 657 | [
"DDInter1429",
"DDInter307"
] | Perflutren | Castor oil | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
1262,
24,
657
]
],
[
[
1262,
24,
927
],
[
927,
63,
657
]
],
[
[
1262,
24,
1491
],
[
1491,
24,
657
]
],
[
[
1262,
25,
985
],
[
985,
... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[
... | Perflutren may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Perflutren may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Mid... |
DB00035 | DB03904 | 1,314 | 1,574 | [
"DDInter507",
"DDInter1903"
] | Desmopressin | Urea | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | Moderate | 1 | [
[
[
1314,
24,
1574
]
],
[
[
1314,
24,
643
],
[
643,
63,
1574
]
],
[
[
1314,
24,
1230
],
[
1230,
24,
1574
]
],
[
[
1314,
24,
643
],
[
643,
... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Urea"
]
],
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
],
[
... | Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Urea
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and ... |
DB01005 | DB14783 | 995 | 287 | [
"DDInter894",
"DDInter574"
] | Hydroxyurea | Diroximel fumarate | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
995,
24,
287
]
],
[
[
995,
63,
599
],
[
599,
24,
287
]
],
[
[
995,
24,
270
],
[
270,
24,
287
]
],
[
[
995,
25,
770
],
[
770,
24,... | [
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
... | Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizum... |
DB00365 | DB09104 | 839 | 286 | [
"DDInter842",
"DDInter1118"
] | Grepafloxacin | Magnesium hydroxide | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
839,
24,
286
]
],
[
[
839,
25,
401
],
[
401,
23,
286
]
],
[
[
839,
23,
60
],
[
60,
23,
286
]
],
[
[
839,
24,
1559
],
[
1559,
23,... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
],
[
... | Grepafloxacin may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Capecitabine and Cape... |
DB00637 | DB06402 | 1,557 | 1,079 | [
"DDInter128",
"DDInter1756"
] | Astemizole | Telavancin | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Moderate | 1 | [
[
[
1557,
24,
1079
]
],
[
[
1557,
23,
112
],
[
112,
23,
1079
]
],
[
[
1557,
24,
657
],
[
657,
63,
1079
]
],
[
[
1557,
24,
543
],
[
543,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telavancin"
]
],
[
[
"Astemizole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Astemizole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Telavancin
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Castor oil and Cast... |
DB00586 | DB00682 | 1,512 | 126 | [
"DDInter537",
"DDInter1951"
] | Diclofenac | Warfarin | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Major | 2 | [
[
[
1512,
25,
126
]
],
[
[
1512,
6,
3486
],
[
3486,
45,
126
]
],
[
[
1512,
63,
443
],
[
443,
23,
126
]
],
[
[
1512,
24,
359
],
[
359,
... | [
[
[
"Diclofenac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
]
],
[
[
"Diclofenac",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"Warfarin"... | Diclofenac (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Warfarin (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone and Spironolactone may cause a minor interaction that can limit clinical effects when taken with Warfarin
Diclofenac may c... |
DB01168 | DB01359 | 1,053 | 729 | [
"DDInter1526",
"DDInter1417"
] | Procarbazine | Penbutolol | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Moderate | 1 | [
[
[
1053,
24,
729
]
],
[
[
1053,
63,
461
],
[
461,
1,
729
]
],
[
[
1053,
24,
699
],
[
699,
40,
729
]
],
[
[
1053,
21,
28698
],
[
28698,
... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
[
... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol (Compound) resembles Penbutolol (Compound)
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Nadolol and Nadolol (Compound) resembles Penbutolol (Compound)
Procarba... |
DB00741 | DB06674 | 167 | 908 | [
"DDInter885",
"DDInter837"
] | Hydrocortisone | Golimumab | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
167,
25,
908
]
],
[
[
167,
23,
1193
],
[
1193,
62,
908
]
],
[
[
167,
62,
1461
],
[
1461,
23,
908
]
],
[
[
167,
24,
336
],
[
336,
... | [
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Hydrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Z... | Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Golimumab
Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Vitamin E an... |
DB00656 | DB01181 | 827 | 1,532 | [
"DDInter1851",
"DDInter906"
] | Trazodone | Ifosfamide | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
827,
24,
1532
]
],
[
[
827,
6,
7524
],
[
7524,
45,
1532
]
],
[
[
827,
21,
28956
],
[
28956,
60,
1532
]
],
[
[
827,
63,
1648
],
[
1648,... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Trazodone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
... | Trazodone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ifosfamide (Compound)
Trazodone (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and ... |
DB01319 | DB09065 | 34 | 760 | [
"DDInter777",
"DDInter424"
] | Fosamprenavir | Cobicistat | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
34,
24,
760
]
],
[
[
34,
63,
1101
],
[
1101,
23,
760
]
],
[
[
34,
23,
1374
],
[
1374,
23,
760
]
],
[
[
34,
63,
1041
],
[
1041,
2... | [
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Fosamprenavir may cause a minor interaction that can limit clinical effects when taken with Abiraterone and Abi... |
DB00860 | DB01072 | 891 | 915 | [
"DDInter1513",
"DDInter129"
] | Prednisolone | Atazanavir | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Moderate | 1 | [
[
[
891,
24,
915
]
],
[
[
891,
24,
1327
],
[
1327,
1,
915
]
],
[
[
891,
6,
4973
],
[
4973,
45,
915
]
],
[
[
891,
21,
29051
],
[
29051,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atazanavir"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
],
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Atazanavir (Compound)
Prednisolone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Atazanavir (Compound)
Prednisolone (Compound) causes Fluid retention (Side Effect) and... |
DB00059 | DB01299 | 1,560 | 698 | [
"DDInter1404",
"DDInter1722"
] | Pegaspargase | Sulfadoxine | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections. | Moderate | 1 | [
[
[
1560,
24,
698
]
],
[
[
1560,
24,
1247
],
[
1247,
40,
698
]
],
[
[
1560,
24,
161
],
[
161,
1,
698
]
],
[
[
1560,
63,
176
],
[
176,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfadoxine"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole (Compound) resembles Sulfadoxine (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine (Compound) resembles S... |
DB09280 | DB13007 | 1,604 | 1,060 | [
"DDInter1101",
"DDInter642"
] | Lumacaftor | Enfortumab vedotin | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Minor | 0 | [
[
[
1604,
23,
1060
]
],
[
[
1604,
63,
590
],
[
590,
24,
1060
]
],
[
[
1604,
64,
1362
],
[
1362,
24,
1060
]
],
[
[
1604,
25,
1480
],
[
1480... | [
[
[
"Lumacaftor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Lumacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
],... | Lumacaftor may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin
Lumacaftor may lead to a major life threatening interaction when taken with Olaparib and Olaparib ... |
DB00372 | DB11186 | 999 | 1,609 | [
"DDInter1793",
"DDInter1427"
] | Thiethylperazine | Pentoxyverine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
999,
24,
1609
]
],
[
[
999,
24,
314
],
[
314,
24,
1609
]
],
[
[
999,
63,
556
],
[
556,
24,
1609
]
],
[
[
999,
25,
306
],
[
306,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Valpro... |
DB00745 | DB12010 | 307 | 214 | [
"DDInter1236",
"DDInter785"
] | Modafinil | Fostamatinib | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
307,
24,
214
]
],
[
[
307,
23,
976
],
[
976,
24,
214
]
],
[
[
307,
62,
723
],
[
723,
24,
214
]
],
[
[
307,
25,
866
],
[
866,
24,... | [
[
[
"Modafinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tofacitinib"
],
[
... | Modafinil may cause a minor interaction that can limit clinical effects when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Modafinil may cause a minor interaction that can limit clinical effects when taken with Aprepitant and Aprepita... |
DB00197 | DB00398 | 1,324 | 79 | [
"DDInter1881",
"DDInter1702"
] | Troglitazone | Sorafenib | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Moderate | 1 | [
[
[
1324,
24,
79
]
],
[
[
1324,
24,
1135
],
[
1135,
62,
79
]
],
[
[
1324,
23,
809
],
[
809,
62,
79
]
],
[
[
1324,
24,
126
],
[
126,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Sorafenib
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Raltegravir and Raltegra... |
DB00099 | DB11952 | 440 | 800 | [
"DDInter735",
"DDInter612"
] | Filgrastim | Duvelisib | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
440,
24,
800
]
],
[
[
440,
24,
310
],
[
310,
24,
800
]
],
[
[
440,
24,
564
],
[
564,
63,
800
]
],
[
[
440,
63,
599
],
[
599,
24,... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib and Abem... |
DB04953 | DB11901 | 495 | 913 | [
"DDInter708",
"DDInter107"
] | Ezogabine | Apalutamide | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
495,
24,
913
]
],
[
[
495,
62,
112
],
[
112,
23,
913
]
],
[
[
495,
63,
600
],
[
600,
24,
913
]
],
[
[
495,
24,
28
],
[
28,
24,
... | [
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Ezogabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Ezogabine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluc... |
DB00374 | DB00686 | 1,061 | 383 | [
"DDInter1852",
"DDInter1424"
] | Treprostinil | Pentosan polysulfate | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. | Moderate | 1 | [
[
[
1061,
24,
383
]
],
[
[
1061,
21,
28708
],
[
28708,
60,
383
]
],
[
[
1061,
63,
20
],
[
20,
24,
383
]
],
[
[
1061,
25,
405
],
[
405,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
]
],
[
[
"Treprostinil",
"{u} (Compound) causes {v} (Side Effect)",
"Malaise"
],
[
"Malaise",
"{u} (Side Effec... | Treprostinil (Compound) causes Malaise (Side Effect) and Malaise (Side Effect) is caused by Pentosan polysulfate (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Tenecteplase and Tenecteplase may cause a moderate interaction that could exacerbate diseases when take... |
DB00224 | DB01129 | 215 | 379 | [
"DDInter917",
"DDInter1559"
] | Indinavir | Rabeprazole | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Moderate | 1 | [
[
[
215,
24,
379
]
],
[
[
215,
24,
1215
],
[
1215,
40,
379
]
],
[
[
215,
24,
660
],
[
660,
1,
379
]
],
[
[
215,
63,
837
],
[
837,
1,... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
[
... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole (Compound) resembles Rabeprazole (Co... |
DB00759 | DB01233 | 1,620 | 1,311 | [
"DDInter1783",
"DDInter1197"
] | Tetracycline | Metoclopramide | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Minor | 0 | [
[
[
1620,
23,
1311
]
],
[
[
1620,
62,
1010
],
[
1010,
23,
1311
]
],
[
[
1620,
63,
1252
],
[
1252,
23,
1311
]
],
[
[
1620,
24,
728
],
[
728... | [
[
[
"Tetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metoclopramide"
]
],
[
[
"Tetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mefloquine"
],
... | Tetracycline may cause a minor interaction that can limit clinical effects when taken with Mefloquine and Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metoclopramide
Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digox... |
DB01267 | DB06663 | 519 | 1,154 | [
"DDInter1381",
"DDInter1398"
] | Paliperidone | Pasireotide | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
519,
25,
1154
]
],
[
[
519,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
519,
62,
112
],
[
112,
23,
1154
]
],
[
[
519,
24,
1385
],
[
1385,
... | [
[
[
"Paliperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Paliperidone",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caus... | Paliperidone (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Paliperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when t... |
DB00945 | DB08886 | 1,479 | 637 | [
"DDInter20",
"DDInter126"
] | Acetylsalicylic acid | Asparaginase Erwinia chrysanthemi | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
1479,
24,
637
]
],
[
[
1479,
63,
167
],
[
167,
24,
637
]
],
[
[
1479,
24,
1220
],
[
1220,
24,
637
]
],
[
[
1479,
25,
1421
],
[
1421,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wi... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Acetylsalicylic acid may cause a moderate interaction that could exacer... |
DB01142 | DB12161 | 1,264 | 730 | [
"DDInter593",
"DDInter512"
] | Doxepin | Deutetrabenazine | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
1264,
24,
730
]
],
[
[
1264,
62,
112
],
[
112,
23,
730
]
],
[
[
1264,
63,
322
],
[
322,
24,
730
]
],
[
[
1264,
24,
971
],
[
971,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Doxepin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Doxepin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Deutetrabenazine
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epir... |
DB01005 | DB11003 | 995 | 748 | [
"DDInter894",
"DDInter100"
] | Hydroxyurea | Anthrax vaccine | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
995,
24,
748
]
],
[
[
995,
63,
322
],
[
322,
24,
748
]
],
[
[
995,
25,
676
],
[
676,
63,
748
]
],
[
[
995,
24,
1683
],
[
1683,
2... | [
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
... | Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Hydroxyurea may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib... |
DB00195 | DB09156 | 726 | 777 | [
"DDInter198",
"DDInter964"
] | Betaxolol (ophthalmic) | Iopromide | Betaxolol is a propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment... | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Moderate | 1 | [
[
[
726,
24,
777
]
],
[
[
726,
24,
1013
],
[
1013,
63,
777
]
],
[
[
726,
1,
88
],
[
88,
24,
777
]
],
[
[
726,
24,
512
],
[
512,
24,
... | [
[
[
"Betaxolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
]
],
[
[
"Betaxolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tyropanoic acid"
],
[
... | Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid and Tyropanoic acid may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Beta... |
DB00802 | DB12010 | 1,322 | 214 | [
"DDInter43",
"DDInter785"
] | Alfentanil | Fostamatinib | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1322,
24,
214
]
],
[
[
1322,
24,
976
],
[
976,
24,
214
]
],
[
[
1322,
64,
723
],
[
723,
24,
214
]
],
[
[
1322,
63,
597
],
[
597,
... | [
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
],
[... | Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Alfentanil may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant may ca... |
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