drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01021 | DB01284 | 674 | 1,042 | [
"DDInter1861",
"DDInter1782"
] | Trichlormethiazide | Tetracosactide | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
674,
24,
1042
]
],
[
[
674,
63,
455
],
[
455,
23,
1042
]
],
[
[
674,
24,
659
],
[
659,
62,
1042
]
],
[
[
674,
24,
761
],
[
761,
... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmete... | Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Vil... |
DB00745 | DB01064 | 307 | 1,148 | [
"DDInter1236",
"DDInter987"
] | Modafinil | Isoprenaline | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
307,
24,
1148
]
],
[
[
307,
24,
480
],
[
480,
24,
1148
]
],
[
[
307,
21,
29316
],
[
29316,
60,
1148
]
],
[
[
307,
62,
251
],
[
251,
... | [
[
[
"Modafinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Modafinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
... | Modafinil may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Modafinil (Compound) causes Sweating (Side Effect) and Sweating (Side Effect) is caused by Isoprenaline (Compou... |
DB08901 | DB10315 | 1,468 | 1,137 | [
"DDInter1492",
"DDInter1127"
] | Ponatinib | Measles virus vaccine live attenuated | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
1468,
25,
1137
]
],
[
[
1468,
24,
119
],
[
119,
64,
1137
]
],
[
[
1468,
64,
273
],
[
273,
25,
1137
]
],
[
[
1468,
24,
384
],
[
384,
... | [
[
[
"Ponatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib and Talazoparib may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Ponatinib may lead to a major life threatening interaction when taken with Tositumomab and Tositumo... |
DB01083 | DB11827 | 1,142 | 433 | [
"DDInter1348",
"DDInter669"
] | Orlistat | Ertugliflozin | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1142,
24,
433
]
],
[
[
1142,
63,
959
],
[
959,
24,
433
]
],
[
[
1142,
24,
624
],
[
624,
24,
433
]
],
[
[
1142,
24,
1412
],
[
1412,
... | [
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotrix may ... |
DB05773 | DB15035 | 1,047 | 503 | [
"DDInter1848",
"DDInter1959"
] | Trastuzumab emtansine | Zanubrutinib | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1047,
25,
503
]
],
[
[
1047,
63,
222
],
[
222,
24,
503
]
],
[
[
1047,
24,
98
],
[
98,
24,
503
]
],
[
[
1047,
25,
39
],
[
39,
25,... | [
[
[
"Trastuzumab emtansine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]... | Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00705 | DB00860 | 441 | 891 | [
"DDInter496",
"DDInter1513"
] | Delavirdine | Prednisolone | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
441,
24,
891
]
],
[
[
441,
63,
1351
],
[
1351,
40,
891
]
],
[
[
441,
64,
175
],
[
175,
40,
891
]
],
[
[
441,
24,
167
],
[
167,
1... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flunisolide"
],
... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Flunisolide and Flunisolide (Compound) resembles Prednisolone (Compound)
Delavirdine may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)
D... |
DB00774 | DB00938 | 1,577 | 455 | [
"DDInter889",
"DDInter1635"
] | Hydroflumethiazide | Salmeterol | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
1577,
24,
455
]
],
[
[
1577,
24,
688
],
[
688,
63,
455
]
],
[
[
1577,
21,
28722
],
[
28722,
60,
455
]
],
[
[
1577,
63,
167
],
[
167,
... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"... | Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Hydroflumethiazide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Salmeter... |
DB00176 | DB12130 | 529 | 1,017 | [
"DDInter770",
"DDInter1094"
] | Fluvoxamine | Lorlatinib | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
529,
24,
1017
]
],
[
[
529,
24,
608
],
[
608,
23,
1017
]
],
[
[
529,
24,
590
],
[
590,
24,
1017
]
],
[
[
529,
24,
1421
],
[
1421,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Aceto... |
DB01610 | DB06616 | 248 | 594 | [
"DDInter1912",
"DDInter224"
] | Valganciclovir | Bosutinib | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
248,
24,
594
]
],
[
[
248,
21,
29231
],
[
29231,
60,
594
]
],
[
[
248,
63,
663
],
[
663,
24,
594
]
],
[
[
248,
24,
1619
],
[
1619,
... | [
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Valganciclovir",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac disorder"
],
[
"Cardiac disorder",
"{u} ... | Valganciclovir (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Bosutinib (Compound)
Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate disease... |
DB00099 | DB09052 | 440 | 250 | [
"DDInter735",
"DDInter220"
] | Filgrastim | Blinatumomab | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Moderate | 1 | [
[
[
440,
24,
250
]
],
[
[
440,
24,
1362
],
[
1362,
63,
250
]
],
[
[
440,
63,
305
],
[
305,
24,
250
]
],
[
[
440,
24,
869
],
[
869,
2... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Blinatumomab"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Blinatumomab
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichi... |
DB00366 | DB00813 | 1,594 | 704 | [
"DDInter600",
"DDInter722"
] | Doxylamine | Fentanyl | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Moderate | 1 | [
[
[
1594,
24,
704
]
],
[
[
1594,
24,
194
],
[
194,
40,
704
]
],
[
[
1594,
40,
939
],
[
939,
40,
704
]
],
[
[
1594,
24,
543
],
[
543,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darifenacin"
],
[
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Darifenacin and Darifenacin (Compound) resembles Fentanyl (Compound)
Doxylamine (Compound) resembles Benzphetamine (Compound) and Benzphetamine (Compound) resembles Fentanyl (Compound)
Doxylamine may cause a moderate interaction ... |
DB00726 | DB00938 | 1,164 | 455 | [
"DDInter1876",
"DDInter1635"
] | Trimipramine | Salmeterol | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
1164,
24,
455
]
],
[
[
1164,
24,
688
],
[
688,
63,
455
]
],
[
[
1164,
6,
8374
],
[
8374,
45,
455
]
],
[
[
1164,
7,
9650
],
[
9650,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
... | Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Trimipramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Salmeterol (Compound)
Trimipramine (... |
DB01114 | DB09034 | 272 | 1,313 | [
"DDInter362",
"DDInter1733"
] | Chlorpheniramine | Suvorexant | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. | Moderate | 1 | [
[
[
272,
24,
1313
]
],
[
[
272,
24,
649
],
[
649,
24,
1313
]
],
[
[
272,
63,
530
],
[
530,
24,
1313
]
],
[
[
272,
74,
100
],
[
100,
... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Suvorexant"
]
],
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
... | Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Suvorexant
Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Dronabino... |
DB00777 | DB06691 | 146 | 849 | [
"DDInter1537",
"DDInter1155"
] | Propiomazine | Mepyramine | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
146,
24,
849
]
],
[
[
146,
63,
1594
],
[
1594,
24,
849
]
],
[
[
146,
1,
324
],
[
324,
40,
849
]
],
[
[
146,
24,
272
],
[
272,
24... | [
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Propiomazine (Compound) resembles Diltiazem (Compound) and Diltiazem (Compound) resembles Mepyramine (Compound... |
DB05351 | DB05541 | 101 | 801 | [
"DDInter519",
"DDInter239"
] | Dexlansoprazole | Brivaracetam | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of, which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generation... | Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 . | Minor | 0 | [
[
[
101,
23,
801
]
],
[
[
101,
63,
126
],
[
126,
23,
801
]
],
[
[
101,
62,
1347
],
[
1347,
24,
801
]
],
[
[
101,
63,
126
],
[
126,
2... | [
[
[
"Dexlansoprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Brivaracetam"
]
],
[
[
"Dexlansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
... | Dexlansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Brivaracetam
Dexlansoprazole may cause a minor interaction that can limit clinical effects when taken with Clopidogrel and C... |
DB01254 | DB14840 | 1,213 | 861 | [
"DDInter484",
"DDInter1601"
] | Dasatinib | Ripretinib | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Moderate | 1 | [
[
[
1213,
24,
861
]
],
[
[
1213,
25,
351
],
[
351,
24,
861
]
],
[
[
1213,
24,
214
],
[
214,
24,
861
]
],
[
[
1213,
63,
353
],
[
353,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ripretinib"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Ribociclib",... | Dasatinib may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may caus... |
DB00519 | DB01390 | 1,638 | 1,117 | [
"DDInter1843",
"DDInter1683"
] | Trandolapril | Sodium bicarbonate | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Minor | 0 | [
[
[
1638,
23,
1117
]
],
[
[
1638,
21,
29093
],
[
29093,
60,
1117
]
],
[
[
1638,
24,
1220
],
[
1220,
23,
1117
]
],
[
[
1638,
1,
954
],
[
95... | [
[
[
"Trandolapril",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Trandolapril",
"{u} (Compound) causes {v} (Side Effect)",
"Fatigue"
],
[
"Fatigue",
"{u} (Side Effect) i... | Trandolapril (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Sodium bicarbonate (Compound)
Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken ... |
DB00652 | DB00902 | 234 | 104 | [
"DDInter1421",
"DDInter1168"
] | Pentazocine | Methdilazine | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
234,
24,
104
]
],
[
[
234,
63,
13
],
[
13,
24,
104
]
],
[
[
234,
24,
820
],
[
820,
1,
104
]
],
[
[
234,
24,
537
],
[
537,
40,
... | [
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazi... |
DB10583 | DB12332 | 949 | 1,619 | [
"DDInter415",
"DDInter1626"
] | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Rucaparib | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
949,
24,
1619
]
],
[
[
949,
63,
259
],
[
259,
24,
1619
]
],
[
[
949,
24,
1019
],
[
1019,
24,
1619
]
],
[
[
949,
24,
1259
],
[
1259,
... | [
[
[
"Clostridium tetani toxoid antigen (formaldehyde inactivated)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Clostridium tetani toxoid antigen (formaldehyde inactivated)",
"{u} may cause a moderate ... | Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Clostridium tetani toxoid antigen (formaldehyde inactivated) ma... |
DB00731 | DB01197 | 1,144 | 1,603 | [
"DDInter1269",
"DDInter292"
] | Nateglinide | Captopril | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Moderate | 1 | [
[
[
1144,
24,
1603
]
],
[
[
1144,
63,
610
],
[
610,
1,
1603
]
],
[
[
1144,
6,
1829
],
[
1829,
45,
1603
]
],
[
[
1144,
21,
28921
],
[
28921... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
[
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Captopril (Compound)
Nateglinide (Compound) binds ALB (Gene) and ALB (Gene) is bound by Captopril (Compound)
Nateglinide (Compound) causes Dizziness (Side Effect) and Dizziness (Side ... |
DB00863 | DB08901 | 1,194 | 1,468 | [
"DDInter1568",
"DDInter1492"
] | Ranitidine | Ponatinib | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Minor | 0 | [
[
[
1194,
23,
1468
]
],
[
[
1194,
24,
478
],
[
478,
24,
1468
]
],
[
[
1194,
6,
12523
],
[
12523,
45,
1468
]
],
[
[
1194,
18,
6797
],
[
679... | [
[
[
"Ranitidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ponatinib"
]
],
[
[
"Ranitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Ranitidine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Ranitidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ponatinib (Compound)
Ranitidine (Compound) ... |
DB00242 | DB00446 | 1,064 | 597 | [
"DDInter392",
"DDInter351"
] | Cladribine | Chloramphenicol | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Major | 2 | [
[
[
1064,
25,
597
]
],
[
[
1064,
18,
10780
],
[
10780,
57,
597
]
],
[
[
1064,
21,
28787
],
[
28787,
60,
597
]
],
[
[
1064,
25,
1101
],
[
1... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Chloramphenicol"
]
],
[
[
"Cladribine",
"{u} (Compound) downregulates {v} (Gene)",
"CCNB2"
],
[
"CCNB2",
"{u} (Gene) is downregulated by {v} (Compoun... | Cladribine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is downregulated by Chloramphenicol (Compound)
Cladribine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Chloramphenicol (Compound)
Cladribine may lead to a major life threatening interaction when taken with Bexarote... |
DB00242 | DB11703 | 1,064 | 405 | [
"DDInter392",
"DDInter9"
] | Cladribine | Acalabrutinib | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
1064,
25,
405
]
],
[
[
1064,
25,
139
],
[
139,
24,
405
]
],
[
[
1064,
64,
58
],
[
58,
24,
405
]
],
[
[
1064,
24,
151
],
[
151,
6... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zidovudine"
],
[
"Zidovudine",
"{u... | Cladribine may lead to a major life threatening interaction when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Cladribine may lead to a major life threatening interaction when taken with Alefacept and Alefacept may cause a moderate int... |
DB00436 | DB00681 | 323 | 1,287 | [
"DDInter179",
"DDInter85"
] | Bendroflumethiazide | Amphotericin B | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Moderate | 1 | [
[
[
323,
24,
1287
]
],
[
[
323,
21,
28714
],
[
28714,
60,
1287
]
],
[
[
323,
24,
663
],
[
663,
24,
1287
]
],
[
[
323,
24,
660
],
[
660,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphotericin B"
]
],
[
[
"Bendroflumethiazide",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (... | Bendroflumethiazide (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Amphotericin B (Compound)
Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases... |
DB00364 | DB09038 | 417 | 1,450 | [
"DDInter1717",
"DDInter636"
] | Sucralfate | Empagliflozin | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
417,
24,
1450
]
],
[
[
417,
23,
461
],
[
461,
24,
1450
]
],
[
[
417,
24,
872
],
[
872,
24,
1450
]
],
[
[
417,
63,
1179
],
[
1179,
... | [
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Sucralfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Timolol"
],
[
... | Sucralfate may cause a minor interaction that can limit clinical effects when taken with Timolol and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxa... |
DB01114 | DB06700 | 272 | 643 | [
"DDInter362",
"DDInter511"
] | Chlorpheniramine | Desvenlafaxine | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
272,
24,
643
]
],
[
[
272,
63,
1100
],
[
1100,
1,
643
]
],
[
[
272,
6,
7390
],
[
7390,
45,
643
]
],
[
[
272,
21,
28709
],
[
28709,
... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine... | Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Chlorpheniramine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Desvenlafaxine (Compound)
Chlorpheniramine (Compound) causes Decreased... |
DB00346 | DB01087 | 472 | 1,520 | [
"DDInter44",
"DDInter1520"
] | Alfuzosin | Primaquine | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
472,
24,
1520
]
],
[
[
472,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
472,
6,
8374
],
[
8374,
45,
1520
]
],
[
[
472,
18,
8800
],
[
8800,
... | [
[
[
"Alfuzosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Alfuzosin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
"Hydr... | Alfuzosin may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Alfuzosin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Primaquine (Compound)
Alfuzosin (Compound) downregulates... |
DB00176 | DB14723 | 529 | 159 | [
"DDInter770",
"DDInter1026"
] | Fluvoxamine | Larotrectinib | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
529,
24,
159
]
],
[
[
529,
25,
222
],
[
222,
23,
159
]
],
[
[
529,
23,
466
],
[
466,
23,
159
]
],
[
[
529,
24,
741
],
[
741,
24,... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Fluvoxamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibu... | Fluvoxamine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Fluvoxamine may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may... |
DB00682 | DB01097 | 126 | 1,377 | [
"DDInter1951",
"DDInter1033"
] | Warfarin | Leflunomide | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Moderate | 1 | [
[
[
126,
24,
1377
]
],
[
[
126,
6,
6017
],
[
6017,
45,
1377
]
],
[
[
126,
63,
1461
],
[
1461,
23,
1377
]
],
[
[
126,
24,
959
],
[
959,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Leflunomide"
]
],
[
[
"Warfarin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Warfarin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Leflunomide
Warfarin may cause a mod... |
DB00889 | DB08912 | 1,133 | 1,040 | [
"DDInter840",
"DDInter462"
] | Granisetron | Dabrafenib | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1133,
24,
1040
]
],
[
[
1133,
6,
8374
],
[
8374,
45,
1040
]
],
[
[
1133,
18,
4729
],
[
4729,
57,
1040
]
],
[
[
1133,
21,
28900
],
[
28... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Granisetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dabrafenib (Compound)
Granisetron (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Dabrafenib (Compound)
Granisetron (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabra... |
DB00284 | DB00288 | 1,647 | 1,103 | [
"DDInter11",
"DDInter63"
] | Acarbose | Amcinonide | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Amcinonide is a corticosteroid. | Minor | 0 | [
[
[
1647,
23,
1103
]
],
[
[
1647,
24,
175
],
[
175,
40,
1103
]
],
[
[
1647,
24,
870
],
[
870,
1,
1103
]
],
[
[
1647,
21,
28787
],
[
28787,... | [
[
[
"Acarbose",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Amcinonide (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Amcinonide... |
DB06822 | DB10344 | 802 | 992 | [
"DDInter1812",
"DDInter818"
] | Tinzaparin | Ginger | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Ginger allergenic extract is used in allergenic testing. | Moderate | 1 | [
[
[
802,
24,
992
]
],
[
[
802,
64,
1578
],
[
1578,
24,
992
]
],
[
[
802,
25,
1421
],
[
1421,
63,
992
]
],
[
[
802,
25,
498
],
[
498,
... | [
[
[
"Tinzaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginger"
]
],
[
[
"Tinzaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lepirudin"
],
[
"Lepirudin",
... | Tinzaparin may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ginger
Tinzaparin may lead to a major life threatening interaction when taken with Betrixaban and Betrixaban may cause a moderate interactio... |
DB00023 | DB00609 | 305 | 595 | [
"DDInter127",
"DDInter694"
] | Asparaginase Escherichia coli | Ethionamide | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | Moderate | 1 | [
[
[
305,
24,
595
]
],
[
[
305,
24,
372
],
[
372,
63,
595
]
],
[
[
305,
64,
1057
],
[
1057,
24,
595
]
],
[
[
305,
24,
176
],
[
176,
2... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethionamide"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide
Asparaginase Escherichia coli may lead to a major life threatening interaction when taken ... |
DB00472 | DB00539 | 758 | 11 | [
"DDInter758",
"DDInter1837"
] | Fluoxetine | Toremifene | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Major | 2 | [
[
[
758,
25,
11
]
],
[
[
758,
63,
1594
],
[
1594,
40,
11
]
],
[
[
758,
24,
1376
],
[
1376,
40,
11
]
],
[
[
758,
40,
11296
],
[
11296,
... | [
[
[
"Fluoxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
"Doxylamine... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine (Compound) resembles Toremifene (Compound)
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Toremifene (... |
DB01232 | DB09098 | 1,327 | 98 | [
"DDInter1640",
"DDInter1700"
] | Saquinavir | Somatrem | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1327,
24,
98
]
],
[
[
1327,
64,
608
],
[
608,
23,
98
]
],
[
[
1327,
63,
168
],
[
168,
23,
98
]
],
[
[
1327,
63,
284
],
[
284,
24... | [
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lidocaine"
],
[
"Lidocaine",
... | Saquinavir may lead to a major life threatening interaction when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Somatrem
Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a mino... |
DB01045 | DB09038 | 463 | 1,450 | [
"DDInter1590",
"DDInter636"
] | Rifampicin | Empagliflozin | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
463,
24,
1450
]
],
[
[
463,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
463,
25,
1017
],
[
1017,
63,
1450
]
],
[
[
463,
25,
1510
],
[
1510,
... | [
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Rifampicin may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may... |
DB06643 | DB12159 | 1,136 | 12 | [
"DDInter500",
"DDInter609"
] | Denosumab | Dupilumab | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL), that indu... | Moderate | 1 | [
[
[
1136,
24,
12
]
],
[
[
1136,
63,
599
],
[
599,
24,
12
]
],
[
[
1136,
24,
713
],
[
713,
24,
12
]
],
[
[
1136,
24,
1011
],
[
1011,
... | [
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dupilumab"
]
],
[
[
"Denosumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
],
[
... | Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Dupilumab
Denosumab may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and ... |
DB00456 | DB01172 | 164 | 416 | [
"DDInter311",
"DDInter1004"
] | Cefalotin | Kanamycin | Cefalotin is a cephalosporin antibiotic. | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Moderate | 1 | [
[
[
164,
24,
416
]
],
[
[
164,
7,
4930
],
[
4930,
57,
416
]
],
[
[
164,
40,
1024
],
[
1024,
63,
416
]
],
[
[
164,
24,
1662
],
[
1662,
... | [
[
[
"Cefalotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kanamycin"
]
],
[
[
"Cefalotin",
"{u} (Compound) upregulates {v} (Gene)",
"DLD"
],
[
"DLD",
"{u} (Gene) is downregulated by {v} (Compou... | Cefalotin (Compound) upregulates DLD (Gene) and DLD (Gene) is downregulated by Kanamycin (Compound)
Cefalotin (Compound) resembles Cefpodoxime (Compound) and Cefpodoxime may cause a moderate interaction that could exacerbate diseases when taken with Kanamycin
Cefalotin may cause a moderate interaction that could exacer... |
DB00196 | DB05294 | 600 | 1,069 | [
"DDInter743",
"DDInter1917"
] | Fluconazole | Vandetanib | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
600,
25,
1069
]
],
[
[
600,
24,
883
],
[
883,
40,
1069
]
],
[
[
600,
6,
8374
],
[
8374,
45,
1069
]
],
[
[
600,
21,
28719
],
[
28719,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"Gefitinib... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Vandetanib (Compound)
Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound)
Fluconazole (Compound) causes Pain (Side Effect) and Pain (Side Ef... |
DB00834 | DB04932 | 932 | 1,564 | [
"DDInter1215",
"DDInter491"
] | Mifepristone | Defibrotide | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Major | 2 | [
[
[
932,
25,
1564
]
],
[
[
932,
63,
1512
],
[
1512,
24,
1564
]
],
[
[
932,
24,
848
],
[
848,
24,
1564
]
],
[
[
932,
24,
1496
],
[
1496,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Defibrotide"
]
],
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
],
[
"Diclo... | Mifepristone may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Defibrotide
Mifepristone may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ib... |
DB01309 | DB13007 | 1,254 | 1,060 | [
"DDInter933",
"DDInter642"
] | Insulin glulisine | Enfortumab vedotin | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
1254,
24,
1060
]
],
[
[
1254,
63,
590
],
[
590,
24,
1060
]
],
[
[
1254,
24,
1281
],
[
1281,
24,
1060
]
],
[
[
1254,
24,
1385
],
[
1385... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aceto... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when take... |
DB00951 | DB05773 | 1,072 | 1,047 | [
"DDInter986",
"DDInter1848"
] | Isoniazid | Trastuzumab emtansine | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
1072,
24,
1047
]
],
[
[
1072,
24,
375
],
[
375,
63,
1047
]
],
[
[
1072,
63,
458
],
[
458,
24,
1047
]
],
[
[
1072,
24,
1488
],
[
1488,
... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol... | Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol and Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Isoniazid may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00332 | DB00405 | 1,089 | 128 | [
"DDInter970",
"DDInter517"
] | Ipratropium | Dexbrompheniramine | Ipratropium is a quaternary ammonium derivative of [atropine] that acts as an anticholinergic agent. It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its... | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Moderate | 1 | [
[
[
1089,
24,
128
]
],
[
[
1089,
24,
662
],
[
662,
63,
128
]
],
[
[
1089,
18,
20113
],
[
20113,
57,
128
]
],
[
[
1089,
24,
1386
],
[
1386,... | [
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
]
],
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
... | Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Ipratropium (Compound) downregulates IER3 (Gene) and IER3 (Gene) is downregulated by Dexbrompheni... |
DB09128 | DB11901 | 1,241 | 913 | [
"DDInter231",
"DDInter107"
] | Brexpiprazole | Apalutamide | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1241,
24,
913
]
],
[
[
1241,
64,
600
],
[
600,
24,
913
]
],
[
[
1241,
25,
1619
],
[
1619,
63,
913
]
],
[
[
1241,
63,
1450
],
[
1450,
... | [
[
[
"Brexpiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Brexpiprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
"Fl... | Brexpiprazole may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Brexpiprazole may lead to a major life threatening interaction when taken with Rucaparib and Rucaparib may cause a modera... |
DB00747 | DB01181 | 1,442 | 1,532 | [
"DDInter1647",
"DDInter906"
] | Scopolamine | Ifosfamide | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
1442,
24,
1532
]
],
[
[
1442,
21,
28900
],
[
28900,
60,
1532
]
],
[
[
1442,
63,
684
],
[
684,
24,
1532
]
],
[
[
1442,
24,
1170
],
[
11... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Scopolamine",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Eff... | Scopolamine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Ifosfamide (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thioridazine may cause a moderate interaction that could exacerbate diseases when ta... |
DB00176 | DB01259 | 529 | 392 | [
"DDInter770",
"DDInter1024"
] | Fluvoxamine | Lapatinib | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
529,
24,
392
]
],
[
[
529,
6,
4973
],
[
4973,
45,
392
]
],
[
[
529,
21,
28688
],
[
28688,
60,
392
]
],
[
[
529,
23,
1135
],
[
1135,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Fluvoxamine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Fluvoxamine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Fluvoxamine (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Lapatinib (Compound)
Fluvoxamine may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxego... |
DB09054 | DB12240 | 384 | 110 | [
"DDInter905",
"DDInter1485"
] | Idelalisib | Polatuzumab vedotin | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Major | 2 | [
[
[
384,
25,
110
]
],
[
[
384,
64,
129
],
[
129,
23,
110
]
],
[
[
384,
25,
913
],
[
913,
23,
110
]
],
[
[
384,
64,
467
],
[
467,
24,... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",... | Idelalisib may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Polatuzumab vedotin
Idelalisib may lead to a major life threatening interaction when taken with Apalutamide and Apalutamide may cause a ... |
DB00783 | DB01142 | 1,438 | 1,264 | [
"DDInter679",
"DDInter593"
] | Estradiol | Doxepin | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Minor | 0 | [
[
[
1438,
23,
1264
]
],
[
[
1438,
6,
4973
],
[
4973,
45,
1264
]
],
[
[
1438,
18,
19557
],
[
19557,
57,
1264
]
],
[
[
1438,
21,
29226
],
[
... | [
[
[
"Estradiol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doxepin"
]
],
[
[
"Estradiol",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"D... | Estradiol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Doxepin (Compound)
Estradiol (Compound) downregulates FAM69A (Gene) and FAM69A (Gene) is downregulated by Doxepin (Compound)
Estradiol (Compound) causes Sinusitis (Side Effect) and Sinusitis (Side Effect) is caused by Doxepin (Compound)
Estradiol (Com... |
DB00209 | DB00612 | 352 | 1,121 | [
"DDInter1886",
"DDInter216"
] | Trospium | Bisoprolol | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Moderate | 1 | [
[
[
352,
24,
1121
]
],
[
[
352,
24,
819
],
[
819,
40,
1121
]
],
[
[
352,
6,
12523
],
[
12523,
45,
1121
]
],
[
[
352,
21,
28850
],
[
28850,... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisoprolol"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Bisoprolol (Compound)
Trospium (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bisoprolol (Compound)
Trospium (Compound) causes Back pain (Side Effect) and Back pain (Side... |
DB00046 | DB09098 | 1,179 | 98 | [
"DDInter940",
"DDInter1700"
] | Insulin lispro | Somatrem | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1179,
24,
98
]
],
[
[
1179,
24,
168
],
[
168,
23,
98
]
],
[
[
1179,
24,
1573
],
[
1573,
24,
98
]
],
[
[
1179,
24,
192
],
[
192,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somatrem
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Pr... |
DB00328 | DB00397 | 831 | 1,466 | [
"DDInter921",
"DDInter1458"
] | Indomethacin | Phenylpropanolamine | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Moderate | 1 | [
[
[
831,
24,
1466
]
],
[
[
831,
21,
28717
],
[
28717,
60,
1466
]
],
[
[
831,
24,
1662
],
[
1662,
63,
1466
]
],
[
[
831,
63,
245
],
[
245,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylpropanolamine"
]
],
[
[
"Indomethacin",
"{u} (Compound) causes {v} (Side Effect)",
"Flushing"
],
[
"Flushing",
"{u} (Side Effe... | Indomethacin (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Phenylpropanolamine (Compound)
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Picosulfuric acid may cause a moderate interaction that could exacerbate disease... |
DB08896 | DB12457 | 292 | 1,180 | [
"DDInter1576",
"DDInter1598"
] | Regorafenib | Rimegepant | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals. It received FDA approval on February 27, 2020 for the acute treatment migraine headache, and was subsequently approved by the European Commission in April 2022 for both the treatment and prevention of migraines. While several p... | Moderate | 1 | [
[
[
292,
24,
1180
]
],
[
[
292,
25,
283
],
[
283,
63,
1180
]
],
[
[
292,
24,
26
],
[
26,
24,
1180
]
],
[
[
292,
24,
159
],
[
159,
63... | [
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rimegepant"
]
],
[
[
"Regorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratin... | Regorafenib may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Rimegepant
Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Afatinib and Afatinib may cause a ... |
DB00307 | DB00607 | 1,101 | 1,249 | [
"DDInter202",
"DDInter1256"
] | Bexarotene | Nafcillin | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Minor | 0 | [
[
[
1101,
23,
1249
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
1249
]
],
[
[
1101,
21,
28792
],
[
28792,
60,
1249
]
],
[
[
1101,
62,
168
],
[
16... | [
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nafcillin"
]
],
[
[
"Bexarotene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nafcillin (Compound)
Bexarotene (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Nafcillin (Compound)
Bexarotene may cause a minor interaction that can limit clinical effects when ta... |
DB00092 | DB01033 | 58 | 328 | [
"DDInter40",
"DDInter1156"
] | Alefacept | Mercaptopurine | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Moderate | 1 | [
[
[
58,
24,
328
]
],
[
[
58,
24,
663
],
[
663,
23,
328
]
],
[
[
58,
24,
126
],
[
126,
24,
328
]
],
[
[
58,
24,
384
],
[
384,
63,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warf... |
DB00701 | DB01261 | 1,091 | 170 | [
"DDInter90",
"DDInter1679"
] | Amprenavir | Sitagliptin | Amprenavir is a protease inhibitor used to treat HIV infection. | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1091,
24,
170
]
],
[
[
1091,
6,
3486
],
[
3486,
45,
170
]
],
[
[
1091,
21,
28792
],
[
28792,
60,
170
]
],
[
[
1091,
24,
52
],
[
52,
... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Amprenavir",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)"... | Amprenavir (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sitagliptin (Compound)
Amprenavir (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Sitagliptin (Compound)
Amprenavir may cause a moderate interaction that could exacerbate diseases w... |
DB00985 | DB01181 | 1,443 | 1,532 | [
"DDInter562",
"DDInter906"
] | Dimenhydrinate | Ifosfamide | Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyl... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
1443,
24,
1532
]
],
[
[
1443,
21,
28956
],
[
28956,
60,
1532
]
],
[
[
1443,
40,
307
],
[
307,
23,
1532
]
],
[
[
1443,
24,
401
],
[
401... | [
[
[
"Dimenhydrinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Dimenhydrinate",
"{u} (Compound) causes {v} (Side Effect)",
"Palpitations"
],
[
"Palpitations",
"{u} (Side E... | Dimenhydrinate (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Dimenhydrinate (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Ifosfamide
Dimenhydrinate may cause a moderat... |
DB01619 | DB11130 | 830 | 407 | [
"DDInter1441",
"DDInter1344"
] | Phenindamine | Opium | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
830,
24,
407
]
],
[
[
830,
63,
556
],
[
556,
24,
407
]
],
[
[
830,
24,
1580
],
[
1580,
24,
407
]
],
[
[
830,
24,
418
],
[
418,
6... | [
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Phenindamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valproic acid"
],
[
... | Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Valproic acid and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Opium
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol and ... |
DB11837 | DB13179 | 1,297 | 68 | [
"DDInter1351",
"DDInter1882"
] | Osilodrostat | Troleandomycin | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | A macrolide antibiotic that is similar to erythromycin. | Major | 2 | [
[
[
1297,
25,
68
]
],
[
[
1297,
63,
1101
],
[
1101,
23,
68
]
],
[
[
1297,
62,
222
],
[
222,
23,
68
]
],
[
[
1297,
23,
466
],
[
466,
... | [
[
[
"Osilodrostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Troleandomycin"
]
],
[
[
"Osilodrostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Be... | Osilodrostat may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Osilodrostat may cause a minor interaction that can limit clinical effects when taken with Sibutramine and S... |
DB00758 | DB01259 | 1,347 | 392 | [
"DDInter413",
"DDInter1024"
] | Clopidogrel | Lapatinib | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1347,
24,
392
]
],
[
[
1347,
6,
4973
],
[
4973,
45,
392
]
],
[
[
1347,
18,
5795
],
[
5795,
46,
392
]
],
[
[
1347,
7,
4602
],
[
4602,
... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Clopidogrel",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Clopidogrel (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Clopidogrel (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is upregulated by Lapatinib (Compound)
Clopidogrel (Compound) upregulates SUPV3L1 (Gene) and SUPV3L1 (Gene) is downregulated by Lapatinib (Compound)
Clopidogrel ... |
DB00794 | DB11581 | 759 | 1,456 | [
"DDInter1521",
"DDInter1926"
] | Primidone | Venetoclax | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
759,
25,
1456
]
],
[
[
759,
25,
1135
],
[
1135,
23,
1456
]
],
[
[
759,
24,
259
],
[
259,
24,
1456
]
],
[
[
759,
25,
1476
],
[
1476,
... | [
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may c... | Primidone may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a mode... |
DB00999 | DB09268 | 504 | 1,662 | [
"DDInter883",
"DDInter1464"
] | Hydrochlorothiazide | Picosulfuric acid | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
504,
24,
1662
]
],
[
[
504,
24,
708
],
[
708,
24,
1662
]
],
[
[
504,
63,
1573
],
[
1573,
24,
1662
]
],
[
[
504,
62,
964
],
[
964,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Co... | Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when t... |
DB00911 | DB06674 | 458 | 908 | [
"DDInter1811",
"DDInter837"
] | Tinidazole | Golimumab | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
458,
24,
908
]
],
[
[
458,
63,
268
],
[
268,
24,
908
]
],
[
[
458,
24,
697
],
[
697,
24,
908
]
],
[
[
458,
24,
505
],
[
505,
63,... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
]... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00279 | DB00621 | 1,152 | 1,026 | [
"DDInter1074",
"DDInter1357"
] | Liothyronine | Oxandrolone | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | A synthetic hormone with anabolic and androgenic properties. | Moderate | 1 | [
[
[
1152,
24,
1026
]
],
[
[
1152,
24,
1546
],
[
1546,
1,
1026
]
],
[
[
1152,
24,
473
],
[
473,
63,
1026
]
],
[
[
1152,
1,
624
],
[
624,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxandrolone"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Oxandrolone (Compound)
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may cause a moderate... |
DB00624 | DB08889 | 1,561 | 350 | [
"DDInter1776",
"DDInter299"
] | Testosterone (topical) | Carfilzomib | Testosterone is an androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5.. It has a role as an androgen, a human metabolite, a Daphnia magna metabolite and a mouse metabolite. It is a 17beta-hydroxy steroid, an androstanoid, a C19-steroid and a 3-oxo-Delta(4) steroid. | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Major | 2 | [
[
[
1561,
25,
350
]
],
[
[
1561,
6,
4973
],
[
4973,
45,
350
]
],
[
[
1561,
21,
28762
],
[
28762,
60,
350
]
],
[
[
1561,
63,
482
],
[
482,
... | [
[
[
"Testosterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carfilzomib"
]
],
[
[
"Testosterone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Carf... | Testosterone may lead to a major life threatening interaction when taken with Carfilzomib
Testosterone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Carfilzomib (Compound)
Testosterone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Testosterone may c... |
DB05812 | DB12240 | 1,374 | 110 | [
"DDInter8",
"DDInter1485"
] | Abiraterone | Polatuzumab vedotin | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
1374,
24,
110
]
],
[
[
1374,
25,
129
],
[
129,
23,
110
]
],
[
[
1374,
63,
372
],
[
372,
24,
110
]
],
[
[
1374,
25,
1593
],
[
1593,
... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Abiraterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
... | Abiraterone may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Polatuzumab vedotin
Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofara... |
DB00285 | DB01064 | 1,100 | 1,148 | [
"DDInter1927",
"DDInter987"
] | Venlafaxine | Isoprenaline | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
1100,
24,
1148
]
],
[
[
1100,
24,
1636
],
[
1636,
24,
1148
]
],
[
[
1100,
21,
28717
],
[
28717,
60,
1148
]
],
[
[
1100,
40,
534
],
[
5... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Venlafaxine (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Isoprenali... |
DB11581 | DB12941 | 1,456 | 466 | [
"DDInter1926",
"DDInter481"
] | Venetoclax | Darolutamide | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
1456,
24,
466
]
],
[
[
1456,
64,
1622
],
[
1622,
23,
466
]
],
[
[
1456,
25,
351
],
[
351,
23,
466
]
],
[
[
1456,
63,
86
],
[
86,
... | [
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Venetoclax",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voriconazole"
],
[
"Vorico... | Venetoclax may lead to a major life threatening interaction when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Venetoclax may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a minor int... |
DB11581 | DB14568 | 1,456 | 982 | [
"DDInter1926",
"DDInter1000"
] | Venetoclax | Ivosidenib | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
1456,
24,
982
]
],
[
[
1456,
64,
271
],
[
271,
23,
982
]
],
[
[
1456,
63,
1101
],
[
1101,
23,
982
]
],
[
[
1456,
64,
976
],
[
976,
... | [
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Venetoclax",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mirabegron"
],
[
"Mirabegron... | Venetoclax may lead to a major life threatening interaction when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a ... |
DB00959 | DB00982 | 1,486 | 1,517 | [
"DDInter1191",
"DDInter991"
] | Methylprednisolone | Isotretinoin | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Moderate | 1 | [
[
[
1486,
24,
1517
]
],
[
[
1486,
18,
7095
],
[
7095,
46,
1517
]
],
[
[
1486,
7,
10578
],
[
10578,
46,
1517
]
],
[
[
1486,
21,
28672
],
[
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isotretinoin"
]
],
[
[
"Methylprednisolone",
"{u} (Compound) downregulates {v} (Gene)",
"CCL2"
],
[
"CCL2",
"{u} (Gene) is upr... | Methylprednisolone (Compound) downregulates CCL2 (Gene) and CCL2 (Gene) is upregulated by Isotretinoin (Compound)
Methylprednisolone (Compound) upregulates PRKAG2 (Gene) and PRKAG2 (Gene) is upregulated by Isotretinoin (Compound)
Methylprednisolone (Compound) causes Secondary infection (Side Effect) and Secondary infec... |
DB00970 | DB14443 | 0 | 987 | [
"DDInter466",
"DDInter1931"
] | Dactinomycin | Vibrio cholerae CVD 103-HgR strain live antigen | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
0,
24,
987
]
],
[
[
0,
63,
141
],
[
141,
24,
987
]
],
[
[
0,
24,
1224
],
[
1224,
24,
987
]
],
[
[
0,
64,
581
],
[
581,
24,
... | [
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with... | Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Dactinomycin may cause a moderate interaction that could exacerbate dis... |
DB04908 | DB09488 | 1,671 | 103 | [
"DDInter741",
"DDInter23"
] | Flibanserin | Acrivastine | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
1671,
24,
103
]
],
[
[
1671,
63,
85
],
[
85,
24,
103
]
],
[
[
1671,
64,
543
],
[
543,
24,
103
]
],
[
[
1671,
24,
849
],
[
849,
2... | [
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
],
[
... | Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Flibanserin may lead to a major life threatening interaction when taken with Loperamide and Loperamide may cause a... |
DB00026 | DB11760 | 1,184 | 119 | [
"DDInter94",
"DDInter1742"
] | Anakinra | Talazoparib | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
1184,
24,
119
]
],
[
[
1184,
24,
66
],
[
66,
24,
119
]
],
[
[
1184,
24,
1129
],
[
1129,
63,
119
]
],
[
[
1184,
25,
1137
],
[
1137,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serot... |
DB00015 | DB08816 | 582 | 578 | [
"DDInter1585",
"DDInter1802"
] | Reteplase | Ticagrelor | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
582,
24,
578
]
],
[
[
582,
23,
297
],
[
297,
62,
578
]
],
[
[
582,
24,
191
],
[
191,
23,
578
]
],
[
[
582,
64,
1578
],
[
1578,
2... | [
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Reteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clov... | Reteplase may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Aminocaproic acid and Aminocaproic ac... |
DB00264 | DB01142 | 88 | 1,264 | [
"DDInter1200",
"DDInter593"
] | Metoprolol | Doxepin | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
88,
24,
1264
]
],
[
[
88,
24,
401
],
[
401,
24,
1264
]
],
[
[
88,
6,
4973
],
[
4973,
45,
1264
]
],
[
[
88,
21,
28898
],
[
28898,
... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Metoprolol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Doxepin (Compound)
Metoprolol (Compound) ... |
DB00734 | DB01166 | 1,664 | 477 | [
"DDInter1605",
"DDInter379"
] | Risperidone | Cilostazol | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
1664,
24,
477
]
],
[
[
1664,
6,
8374
],
[
8374,
45,
477
]
],
[
[
1664,
21,
28919
],
[
28919,
60,
477
]
],
[
[
1664,
23,
112
],
[
112,
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Risperidone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Risperidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Risperidone (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Cilostazol (Compound)
Risperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and ... |
DB01403 | DB08871 | 9 | 36 | [
"DDInter1175",
"DDInter666"
] | Methotrimeprazine | Eribulin | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
9,
24,
36
]
],
[
[
9,
63,
1424
],
[
1424,
24,
36
]
],
[
[
9,
1,
820
],
[
820,
24,
36
]
],
[
[
9,
24,
28
],
[
28,
63,
36
... | [
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],... | Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Methotrimeprazine (Compound) resembles Alimemazine (Compound) and Alimemazine may cause a moderate interaction th... |
DB00620 | DB00876 | 175 | 1,414 | [
"DDInter1855",
"DDInter658"
] | Triamcinolone | Eprosartan | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced. | Moderate | 1 | [
[
[
175,
24,
1414
]
],
[
[
175,
24,
240
],
[
240,
40,
1414
]
],
[
[
175,
21,
29291
],
[
29291,
60,
1414
]
],
[
[
175,
63,
176
],
[
176,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eprosartan"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Losartan"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) resembles Eprosartan (Compound)
Triamcinolone (Compound) causes Muscular weakness (Side Effect) and Muscular weakness (Side Effect) is caused by Eprosartan (Compound)
Triamcinolone may cause a ... |
DB08820 | DB11760 | 1,478 | 119 | [
"DDInter997",
"DDInter1742"
] | Ivacaftor | Talazoparib | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
1478,
24,
119
]
],
[
[
1478,
64,
441
],
[
441,
24,
119
]
],
[
[
1478,
24,
985
],
[
985,
24,
119
]
],
[
[
1478,
25,
1339
],
[
1339,
... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Ivacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Delavirdine"
],
[
"Delavirdin... | Ivacaftor may lead to a major life threatening interaction when taken with Delavirdine and Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib and Osimertinib may cau... |
DB00235 | DB01143 | 444 | 923 | [
"DDInter1221",
"DDInter65"
] | Milrinone | Amifostine | Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. Often the result of long-term myocardial ischemia, cardiomyopathy, or other cardiac insults, heart failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and metabolites, resulting... | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
444,
24,
923
]
],
[
[
444,
21,
28778
],
[
28778,
60,
923
]
],
[
[
444,
1,
1111
],
[
1111,
63,
923
]
],
[
[
444,
21,
28778
],
[
28778,
... | [
[
[
"Milrinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Milrinone",
"{u} (Compound) causes {v} (Side Effect)",
"Anaphylactic shock"
],
[
"Anaphylactic shock",
"{u} (Side... | Milrinone (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Amifostine (Compound)
Milrinone (Compound) resembles Amrinone (Compound) and Amrinone may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Milrinone (Compound) causes Anap... |
DB00285 | DB00295 | 1,100 | 475 | [
"DDInter1927",
"DDInter1244"
] | Venlafaxine | Morphine | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Moderate | 1 | [
[
[
1100,
24,
475
]
],
[
[
1100,
6,
12523
],
[
12523,
45,
475
]
],
[
[
1100,
21,
28784
],
[
28784,
60,
475
]
],
[
[
1100,
24,
22
],
[
22,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
]
],
[
[
"Venlafaxine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",... | Venlafaxine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Morphine (Compound)
Venlafaxine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Morphine (Compound)
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Ephedr... |
DB01222 | DB10343 | 617 | 962 | [
"DDInter246",
"DDInter160"
] | Budesonide | Bacillus calmette-guerin substrain tice live antigen | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Moderate | 1 | [
[
[
617,
24,
962
]
],
[
[
617,
64,
1057
],
[
1057,
25,
962
]
],
[
[
617,
24,
1213
],
[
1213,
25,
962
]
],
[
[
617,
24,
270
],
[
270,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Budesonide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"... | Budesonide may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib... |
DB00153 | DB00910 | 1,331 | 1,041 | [
"DDInter662",
"DDInter1394"
] | Ergocalciferol | Paricalcitol | Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolat... | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Major | 2 | [
[
[
1331,
36,
1041
]
],
[
[
1331,
36,
386
],
[
386,
25,
1041
]
],
[
[
1331,
40,
1113
],
[
1113,
1,
1041
]
],
[
[
1331,
1,
11457
],
[
11457... | [
[
[
"Ergocalciferol",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",
"Paricalcitol"
]
],
[
[
"Ergocalciferol",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening ... | Ergocalciferol (Compound) resembles Paricalcitol (Compound) and
Ergocalciferol (Compound) resembles Cholecalciferol (Compound) and Ergocalciferol may lead to a major life threatening interaction when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Paricalc... |
DB04855 | DB06176 | 540 | 1,342 | [
"DDInter602",
"DDInter1616"
] | Dronedarone | Romidepsin | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Major | 2 | [
[
[
540,
25,
1342
]
],
[
[
540,
62,
112
],
[
112,
23,
1342
]
],
[
[
540,
64,
485
],
[
485,
24,
1342
]
],
[
[
540,
25,
1616
],
[
1616,
... | [
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Romidepsin"
]
],
[
[
"Dronedarone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Dronedarone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Dronedarone may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may ... |
DB01149 | DB01216 | 851 | 284 | [
"DDInter1274",
"DDInter736"
] | Nefazodone | Finasteride | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Finasteride is a synthetic 4-azasteroid compound and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). It works in a similar fashion as [dutasteride], which is another 5-alpha-reductase inhibitor, by exerting a... | Moderate | 1 | [
[
[
851,
24,
284
]
],
[
[
851,
6,
6799
],
[
6799,
45,
284
]
],
[
[
851,
21,
29247
],
[
29247,
60,
284
]
],
[
[
851,
24,
98
],
[
98,
... | [
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Finasteride"
]
],
[
[
"Nefazodone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7"
],
[
"CYP3A7",
"{u} (Gene) is bound by {v} (Compound)"... | Nefazodone (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Finasteride (Compound)
Nefazodone (Compound) causes Pharyngitis (Side Effect) and Pharyngitis (Side Effect) is caused by Finasteride (Compound)
Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and ... |
DB00295 | DB00622 | 475 | 1,081 | [
"DDInter1244",
"DDInter1287"
] | Morphine | Nicardipine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Moderate | 1 | [
[
[
475,
24,
1081
]
],
[
[
475,
24,
409
],
[
409,
1,
1081
]
],
[
[
475,
63,
1428
],
[
1428,
1,
1081
]
],
[
[
475,
6,
12523
],
[
12523,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nicardipine"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Felodipine and Felodipine (Compound) resembles Nicardipine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Nicardipine (Compound)
Mo... |
DB06697 | DB08912 | 436 | 1,040 | [
"DDInter121",
"DDInter462"
] | Artemether | Dabrafenib | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
436,
24,
1040
]
],
[
[
436,
6,
8374
],
[
8374,
45,
1040
]
],
[
[
436,
63,
1101
],
[
1101,
23,
1040
]
],
[
[
436,
24,
1478
],
[
1478,
... | [
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Artemether",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Artemether (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dabrafenib (Compound)
Artemether may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Dabrafenib
Artemether may cause... |
DB00446 | DB01168 | 597 | 1,053 | [
"DDInter351",
"DDInter1526"
] | Chloramphenicol | Procarbazine | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
597,
24,
1053
]
],
[
[
597,
7,
7448
],
[
7448,
46,
1053
]
],
[
[
597,
18,
4930
],
[
4930,
57,
1053
]
],
[
[
597,
21,
28762
],
[
28762,... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Chloramphenicol",
"{u} (Compound) upregulates {v} (Gene)",
"MOK"
],
[
"MOK",
"{u} (Gene) is upregulated b... | Chloramphenicol (Compound) upregulates MOK (Gene) and MOK (Gene) is upregulated by Procarbazine (Compound)
Chloramphenicol (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Procarbazine (Compound)
Chloramphenicol (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Proca... |
DB00238 | DB11828 | 188 | 1,406 | [
"DDInter1285",
"DDInter1281"
] | Nevirapine | Neratinib | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
188,
25,
1406
]
],
[
[
188,
24,
1135
],
[
1135,
23,
1406
]
],
[
[
188,
24,
392
],
[
392,
24,
1406
]
],
[
[
188,
25,
1510
],
[
1510,
... | [
[
[
"Nevirapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib ma... |
DB00331 | DB01067 | 1,645 | 959 | [
"DDInter1164",
"DDInter826"
] | Metformin | Glipizide | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
1645,
24,
959
]
],
[
[
1645,
63,
245
],
[
245,
40,
959
]
],
[
[
1645,
24,
1411
],
[
1411,
1,
959
]
],
[
[
1645,
5,
11640
],
[
11640,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound)
... |
DB00075 | DB10795 | 541 | 221 | [
"DDInter1250",
"DDInter1486"
] | Muromonab | Poliovirus type 1 antigen (formaldehyde inactivated) | Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
541,
24,
221
]
],
[
[
541,
64,
581
],
[
581,
24,
221
]
],
[
[
541,
24,
599
],
[
599,
24,
221
]
],
[
[
541,
25,
1510
],
[
1510,
2... | [
[
[
"Muromonab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Muromonab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"In... | Muromonab may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Muromonab may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00780 | DB01064 | 551 | 1,148 | [
"DDInter1440",
"DDInter987"
] | Phenelzine | Isoprenaline | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
551,
24,
1148
]
],
[
[
551,
64,
1636
],
[
1636,
24,
1148
]
],
[
[
551,
24,
480
],
[
480,
24,
1148
]
],
[
[
551,
63,
874
],
[
874,
... | [
[
[
"Phenelzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Phenelzine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenylephrine"
],
[
"Pheny... | Phenelzine may lead to a major life threatening interaction when taken with Phenylephrine and Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Phenelzine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol ma... |
DB00557 | DB00747 | 252 | 1,442 | [
"DDInter895",
"DDInter1647"
] | Hydroxyzine | Scopolamine | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
252,
24,
1442
]
],
[
[
252,
63,
19
],
[
19,
24,
1442
]
],
[
[
252,
21,
28766
],
[
28766,
60,
1442
]
],
[
[
252,
24,
543
],
[
543,
... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Hydroxyzine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Scopolami... |
DB00712 | DB12130 | 1,274 | 1,017 | [
"DDInter763",
"DDInter1094"
] | Flurbiprofen | Lorlatinib | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1274,
24,
1017
]
],
[
[
1274,
63,
590
],
[
590,
24,
1017
]
],
[
[
1274,
24,
976
],
[
976,
24,
1017
]
],
[
[
1274,
25,
1421
],
[
1421,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
],
... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib... |
DB00367 | DB12010 | 566 | 214 | [
"DDInter1061",
"DDInter785"
] | Levonorgestrel | Fostamatinib | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
566,
24,
214
]
],
[
[
566,
24,
723
],
[
723,
24,
214
]
],
[
[
566,
63,
600
],
[
600,
24,
214
]
],
[
[
566,
40,
167
],
[
167,
24,... | [
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
]... | Levonorgestrel may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Levonorgestrel may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole... |
DB00316 | DB11901 | 474 | 913 | [
"DDInter14",
"DDInter107"
] | Acetaminophen | Apalutamide | Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the ... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
474,
24,
913
]
],
[
[
474,
24,
1619
],
[
1619,
63,
913
]
],
[
[
474,
24,
322
],
[
322,
24,
913
]
],
[
[
474,
63,
10
],
[
10,
24,... | [
[
[
"Acetaminophen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Acetaminophen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
... | Acetaminophen may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Acetaminophen may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and E... |
DB01020 | DB01069 | 1,107 | 401 | [
"DDInter990",
"DDInter1533"
] | Isosorbide mononitrate | Promethazine | Isosorbide mononitrate is an organic nitrate with vasodilating properties. It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload.[L11698, L11743] Isosorbide mononitrate is an active metabolite of [isosorbide dinitrate]. Li... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1107,
24,
401
]
],
[
[
1107,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1107,
63,
104
],
[
104,
24,
401
]
],
[
[
1107,
21,
28709
],
[
28709,... | [
[
[
"Isosorbide mononitrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Isosorbide mononitrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"D... | Isosorbide mononitrate may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Isosorbide mononitrate may cause a moderate interaction that could exacerbate diseases when taken with M... |
DB00006 | DB00208 | 942 | 1,018 | [
"DDInter217",
"DDInter1804"
] | Bivalirudin | Ticlopidine | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Moderate | 1 | [
[
[
942,
24,
1018
]
],
[
[
942,
24,
1347
],
[
1347,
64,
1018
]
],
[
[
942,
23,
1631
],
[
1631,
62,
1018
]
],
[
[
942,
25,
1271
],
[
1271,
... | [
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticlopidine"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
],
... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel may lead to a major life threatening interaction when taken with Ticlopidine
Bivalirudin may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a... |
DB06700 | DB06706 | 643 | 468 | [
"DDInter511",
"DDInter985"
] | Desvenlafaxine | Isometheptene | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Isometheptene is a sympathomimetic drug that causes vasoconstriction. It is used for treating migraines and tension headaches. | Moderate | 1 | [
[
[
643,
24,
468
]
],
[
[
643,
63,
480
],
[
480,
24,
468
]
],
[
[
643,
40,
1100
],
[
1100,
24,
468
]
],
[
[
643,
24,
144
],
[
144,
6... | [
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isometheptene"
]
],
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
... | Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isometheptene
Desvenlafaxine (Compound) resembles Venlafaxine (Compound) and Venlafaxine may cause a moderate interacti... |
DB09078 | DB14730 | 1,228 | 1,412 | [
"DDInter1036",
"DDInter264"
] | Lenvatinib | Calaspargase pegol | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1228,
24,
1412
]
],
[
[
1228,
63,
322
],
[
322,
24,
1412
]
],
[
[
1228,
64,
868
],
[
868,
24,
1412
]
],
[
[
1228,
24,
484
],
[
484,
... | [
[
[
"Lenvatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Lenvatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
... | Lenvatinib may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Lenvatinib may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib ... |
DB01319 | DB08881 | 34 | 868 | [
"DDInter777",
"DDInter1925"
] | Fosamprenavir | Vemurafenib | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
34,
24,
868
]
],
[
[
34,
6,
8374
],
[
8374,
45,
868
]
],
[
[
34,
21,
29106
],
[
29106,
60,
868
]
],
[
[
34,
64,
608
],
[
608,
23... | [
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Fosamprenavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Fosamprenavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Fosamprenavir (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Vemurafenib (Compound)
Fosamprenavir may lead to a major life threatening interaction when taken with Lidocaine and Lidocaine may... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.