drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB06317 | DB09276 | 1,626 | 381 | [
"DDInter630",
"DDInter1682"
] | Elotuzumab | Sodium aurothiomalate | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
1626,
24,
381
]
],
[
[
1626,
63,
1683
],
[
1683,
24,
381
]
],
[
[
1626,
24,
1593
],
[
1593,
24,
381
]
],
[
[
1626,
25,
375
],
[
375,
... | [
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Elotuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
... | Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Elotuzumab may cause a moderate interaction that could exacerbate diseases when taken with Crizotin... |
DB00191 | DB00899 | 73 | 411 | [
"DDInter1447",
"DDInter1579"
] | Phentermine | Remifentanil | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | Moderate | 1 | [
[
[
73,
24,
411
]
],
[
[
73,
24,
1322
],
[
1322,
40,
411
]
],
[
[
73,
24,
704
],
[
704,
1,
411
]
],
[
[
73,
21,
28680
],
[
28680,
60... | [
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remifentanil"
]
],
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alfentanil"
],
... | Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Alfentanil and Alfentanil (Compound) resembles Remifentanil (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Remifentanil (Compound... |
DB00206 | DB11921 | 1,245 | 1,019 | [
"DDInter1582",
"DDInter492"
] | Reserpine | Deflazacort | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1245,
24,
1019
]
],
[
[
1245,
24,
959
],
[
959,
24,
1019
]
],
[
[
1245,
40,
1340
],
[
1340,
24,
1019
]
],
[
[
1245,
63,
176
],
[
176,
... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Reserpine (Compound) resembles Deserpidine (Compound) and Deserpidine may cause a moderate interaction that could ... |
DB06186 | DB06772 | 1,439 | 310 | [
"DDInter969",
"DDInter259"
] | Ipilimumab | Cabazitaxel | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Moderate | 1 | [
[
[
1439,
24,
310
]
],
[
[
1439,
63,
973
],
[
973,
24,
310
]
],
[
[
1439,
24,
868
],
[
868,
63,
310
]
],
[
[
1439,
24,
1626
],
[
1626,
... | [
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemu... |
DB00532 | DB01211 | 208 | 609 | [
"DDInter1152",
"DDInter393"
] | Mephenytoin | Clarithromycin | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
208,
24,
609
]
],
[
[
208,
64,
600
],
[
600,
23,
609
]
],
[
[
208,
24,
222
],
[
222,
23,
609
]
],
[
[
208,
23,
660
],
[
660,
23,... | [
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Mephenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
"Flu... | Mephenytoin may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Clarithromycin
Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine ma... |
DB00471 | DB01138 | 201 | 804 | [
"DDInter1242",
"DDInter1726"
] | Montelukast | Sulfinpyrazone | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Moderate | 1 | [
[
[
201,
24,
804
]
],
[
[
201,
24,
998
],
[
998,
1,
804
]
],
[
[
201,
6,
3486
],
[
3486,
45,
804
]
],
[
[
201,
24,
1144
],
[
1144,
2... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfinpyrazone"
]
],
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
]... | Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Sulfinpyrazone (Compound)
Montelukast (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sulfinpyrazone (Compound)
Montelukast may cause a moderate interaction tha... |
DB00774 | DB01168 | 1,577 | 1,053 | [
"DDInter889",
"DDInter1526"
] | Hydroflumethiazide | Procarbazine | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
1577,
24,
1053
]
],
[
[
1577,
24,
848
],
[
848,
40,
1053
]
],
[
[
1577,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
1577,
62,
126
],
[
126... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen... | Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
Hydroflumethiazide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Hydroflumethiazide may cause... |
DB00316 | DB00631 | 474 | 372 | [
"DDInter14",
"DDInter405"
] | Acetaminophen | Clofarabine | Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the ... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
474,
24,
372
]
],
[
[
474,
6,
7720
],
[
7720,
46,
372
]
],
[
[
474,
7,
12149
],
[
12149,
57,
372
]
],
[
[
474,
18,
2852
],
[
2852,
... | [
[
[
"Acetaminophen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Acetaminophen",
"{u} (Compound) binds {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is upregulated by {v} (... | Acetaminophen (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Clofarabine (Compound)
Acetaminophen (Compound) upregulates WRB (Gene) and WRB (Gene) is downregulated by Clofarabine (Compound)
Acetaminophen (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is downregulated by Clofarabine (Compound)
... |
DB00367 | DB00459 | 566 | 640 | [
"DDInter1061",
"DDInter21"
] | Levonorgestrel | Acitretin | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. | Major | 2 | [
[
[
566,
25,
640
]
],
[
[
566,
7,
2023
],
[
2023,
46,
640
]
],
[
[
566,
21,
29514
],
[
29514,
60,
640
]
],
[
[
566,
63,
245
],
[
245,
... | [
[
[
"Levonorgestrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acitretin"
]
],
[
[
"Levonorgestrel",
"{u} (Compound) upregulates {v} (Gene)",
"RAP1GAP"
],
[
"RAP1GAP",
"{u} (Gene) is upregulated by {v} (Compo... | Levonorgestrel (Compound) upregulates RAP1GAP (Gene) and RAP1GAP (Gene) is upregulated by Acitretin (Compound)
Levonorgestrel (Compound) causes Influenza like illness (Side Effect) and Influenza like illness (Side Effect) is caused by Acitretin (Compound)
Levonorgestrel may cause a moderate interaction that could exace... |
DB00983 | DB01224 | 480 | 623 | [
"DDInter776",
"DDInter1553"
] | Formoterol | Quetiapine | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
480,
24,
623
]
],
[
[
480,
63,
827
],
[
827,
1,
623
]
],
[
[
480,
6,
12523
],
[
12523,
45,
623
]
],
[
[
480,
21,
29039
],
[
29039,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Formoterol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Quetiapine (Compound)
Formoterol (Compound) causes Cystitis noninfective (Side Effect) and... |
DB00081 | DB10583 | 273 | 949 | [
"DDInter1838",
"DDInter415"
] | Tositumomab | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
273,
24,
949
]
],
[
[
273,
25,
1377
],
[
1377,
24,
949
]
],
[
[
273,
24,
58
],
[
58,
24,
949
]
],
[
[
273,
25,
1259
],
[
1259,
6... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}... | Tositumomab may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Tositumomab may cause a moderate interaction that could exacerbate disease... |
DB00065 | DB04865 | 581 | 4 | [
"DDInter923",
"DDInter1335"
] | Infliximab | Omacetaxine mepesuccinate | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Major | 2 | [
[
[
581,
25,
4
]
],
[
[
581,
25,
1394
],
[
1394,
24,
4
]
],
[
[
581,
25,
994
],
[
994,
63,
4
]
],
[
[
581,
24,
496
],
[
496,
63,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rituximab"
],
[
"Rituximab",... | Infliximab may lead to a major life threatening interaction when taken with Rituximab and Rituximab may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Infliximab may lead to a major life threatening interaction when taken with Risankizumab and Risankizumab may caus... |
DB00352 | DB00580 | 482 | 311 | [
"DDInter1814",
"DDInter1910"
] | Tioguanine | Valdecoxib | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Moderate | 1 | [
[
[
482,
24,
311
]
],
[
[
482,
24,
663
],
[
663,
24,
311
]
],
[
[
482,
63,
1560
],
[
1560,
24,
311
]
],
[
[
482,
24,
1613
],
[
1613,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valdecoxib"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Valdecoxib
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and ... |
DB00289 | DB00563 | 847 | 663 | [
"DDInter132",
"DDInter1174"
] | Atomoxetine | Methotrexate | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
847,
24,
663
]
],
[
[
847,
18,
3741
],
[
3741,
46,
663
]
],
[
[
847,
21,
28850
],
[
28850,
60,
663
]
],
[
[
847,
40,
126
],
[
126,
... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Atomoxetine",
"{u} (Compound) downregulates {v} (Gene)",
"OXA1L"
],
[
"OXA1L",
"{u} (Gene) is upregulated by ... | Atomoxetine (Compound) downregulates OXA1L (Gene) and OXA1L (Gene) is upregulated by Methotrexate (Compound)
Atomoxetine (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Methotrexate (Compound)
Atomoxetine (Compound) resembles Warfarin (Compound) and Warfarin may cause a minor interact... |
DB01015 | DB12245 | 1,247 | 823 | [
"DDInter1724",
"DDInter1863"
] | Sulfamethoxazole | Triclabendazole | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Minor | 0 | [
[
[
1247,
23,
823
]
],
[
[
1247,
62,
112
],
[
112,
23,
823
]
],
[
[
1247,
62,
1010
],
[
1010,
24,
823
]
],
[
[
1247,
23,
77
],
[
77,
... | [
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Triclabendazole"
]
],
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"... | Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Mefl... |
DB00675 | DB01175 | 888 | 318 | [
"DDInter1744",
"DDInter672"
] | Tamoxifen | Escitalopram | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Major | 2 | [
[
[
888,
25,
318
]
],
[
[
888,
64,
1230
],
[
1230,
1,
318
]
],
[
[
888,
6,
8374
],
[
8374,
45,
318
]
],
[
[
888,
18,
7623
],
[
7623,
... | [
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
]
],
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Citalopram"
],
[
"Citalopram",
"{u} (... | Tamoxifen may lead to a major life threatening interaction when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Tamoxifen (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Escitalopram (Compound)
Tamoxifen (Compound) downregulates RRP12 (Gene) and RRP12 (Gene) is downregulat... |
DB06636 | DB09079 | 1,623 | 1,496 | [
"DDInter980",
"DDInter1296"
] | Isavuconazonium | Nintedanib | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Moderate | 1 | [
[
[
1623,
24,
1496
]
],
[
[
1623,
64,
609
],
[
609,
24,
1496
]
],
[
[
1623,
25,
913
],
[
913,
63,
1496
]
],
[
[
1623,
24,
1593
],
[
1593,
... | [
[
[
"Isavuconazonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
]
],
[
[
"Isavuconazonium",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
... | Isavuconazonium may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Isavuconazonium may lead to a major life threatening interaction when taken with Apalutamide and Apalutamide may c... |
DB00563 | DB00743 | 663 | 808 | [
"DDInter1174",
"DDInter792"
] | Methotrexate | Gadobenic acid | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Gadobenic acid, usually available in the salt form gadobenate dimeglumine, is a linear MRI gadolinium-based contrast agent (GBCA) used primarily for MR imaging of the liver. It differs from other GBCAs due to the benzene ring that confers weak protein binding, thus leading to an increased R1 and R2 relaxivity. As gadob... | Moderate | 1 | [
[
[
663,
24,
808
]
],
[
[
663,
6,
1829
],
[
1829,
45,
808
]
],
[
[
663,
21,
28769
],
[
28769,
60,
808
]
],
[
[
663,
63,
589
],
[
589,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadobenic acid"
]
],
[
[
"Methotrexate",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)... | Methotrexate (Compound) binds ALB (Gene) and ALB (Gene) is bound by Gadobenic acid (Compound)
Methotrexate (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Gadobenic acid (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00184 | DB00201 | 763 | 1,684 | [
"DDInter1290",
"DDInter263"
] | Nicotine | Caffeine | Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. | Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but ... | Minor | 0 | [
[
[
763,
23,
1684
]
],
[
[
763,
6,
7950
],
[
7950,
45,
1684
]
],
[
[
763,
21,
29024
],
[
29024,
60,
1684
]
],
[
[
763,
23,
752
],
[
752,
... | [
[
[
"Nicotine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Caffeine"
]
],
[
[
"Nicotine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"... | Nicotine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Caffeine (Compound)
Nicotine (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Caffeine (Compound)
Nicotine may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine... |
DB00877 | DB01319 | 629 | 34 | [
"DDInter1678",
"DDInter777"
] | Sirolimus | Fosamprenavir | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Major | 2 | [
[
[
629,
25,
34
]
],
[
[
629,
64,
1091
],
[
1091,
40,
34
]
],
[
[
629,
6,
8374
],
[
8374,
45,
34
]
],
[
[
629,
21,
29062
],
[
29062,
... | [
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amprenavir"
],
[
"Amprenavir",
"{u} ... | Sirolimus may lead to a major life threatening interaction when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Sirolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosamprenavir (Compound)
Sirolimus (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side E... |
DB01285 | DB09038 | 708 | 1,450 | [
"DDInter445",
"DDInter636"
] | Corticotropin | Empagliflozin | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
708,
24,
1450
]
],
[
[
708,
63,
461
],
[
461,
24,
1450
]
],
[
[
708,
23,
659
],
[
659,
63,
1450
]
],
[
[
708,
24,
192
],
[
192,
... | [
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
... | Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Corticotropin may cause a minor interaction that can limit clinical effects when taken with Vilanterol and Vilan... |
DB09038 | DB09098 | 1,450 | 98 | [
"DDInter636",
"DDInter1700"
] | Empagliflozin | Somatrem | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1450,
24,
98
]
],
[
[
1450,
24,
1612
],
[
1612,
62,
98
]
],
[
[
1450,
63,
168
],
[
168,
23,
98
]
],
[
[
1450,
63,
336
],
[
336,
... | [
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
... | Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Somatrem
Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bo... |
DB00983 | DB11796 | 480 | 1,612 | [
"DDInter776",
"DDInter786"
] | Formoterol | Fostemsavir | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
480,
24,
1612
]
],
[
[
480,
63,
1324
],
[
1324,
23,
1612
]
],
[
[
480,
23,
1220
],
[
1220,
23,
1612
]
],
[
[
480,
63,
1424
],
[
1424,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Formoterol may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and De... |
DB00270 | DB14724 | 1,428 | 48 | [
"DDInter993",
"DDInter634"
] | Isradipine | Emapalumab | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority... | Moderate | 1 | [
[
[
1428,
24,
48
]
],
[
[
1428,
1,
376
],
[
376,
24,
48
]
],
[
[
1428,
40,
854
],
[
854,
24,
48
]
],
[
[
1428,
23,
467
],
[
467,
24,... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Emapalumab"
]
],
[
[
"Isradipine",
"{u} (Compound) resembles {v} (Compound)",
"Amlodipine"
],
[
"Amlodipine",
"{u} may cause a moderat... | Isradipine (Compound) resembles Amlodipine (Compound) and Amlodipine may cause a moderate interaction that could exacerbate diseases when taken with Emapalumab
Isradipine (Compound) resembles Nimodipine (Compound) and Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Emapalumab
... |
DB00915 | DB01176 | 1,170 | 537 | [
"DDInter60",
"DDInter453"
] | Amantadine | Cyclizine | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesi... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1170,
24,
537
]
],
[
[
1170,
24,
1511
],
[
1511,
63,
537
]
],
[
[
1170,
63,
104
],
[
104,
1,
537
]
],
[
[
1170,
24,
830
],
[
830,
... | [
[
[
"Amantadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Amantadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Met... |
DB00512 | DB00626 | 91 | 1,441 | [
"DDInter1916",
"DDInter161"
] | Vancomycin | Bacitracin | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Bacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Bacitracin was granted FDA approval on 29 July 1948.[A... | Moderate | 1 | [
[
[
91,
24,
1441
]
],
[
[
91,
24,
1481
],
[
1481,
1,
1441
]
],
[
[
91,
21,
28719
],
[
28719,
60,
1441
]
],
[
[
91,
24,
648
],
[
648,
... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bacitracin"
]
],
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polymyxin B"
],
[
... | Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B and Polymyxin B (Compound) resembles Bacitracin (Compound)
Vancomycin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Bacitracin (Compound)
Vancomycin may cause a moderate interaction that cou... |
DB01042 | DB01610 | 1,307 | 248 | [
"DDInter1144",
"DDInter1912"
] | Melphalan | Valganciclovir | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Moderate | 1 | [
[
[
1307,
24,
248
]
],
[
[
1307,
63,
563
],
[
563,
1,
248
]
],
[
[
1307,
21,
29209
],
[
29209,
60,
248
]
],
[
[
1307,
63,
1238
],
[
1238,
... | [
[
[
"Melphalan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]
],
[
[
"Melphalan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
],
[... | Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Melphalan (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Valganciclovir (Compound)
Melphalan may cause a moderate interac... |
DB00295 | DB01080 | 475 | 855 | [
"DDInter1244",
"DDInter1933"
] | Morphine | Vigabatrin | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Moderate | 1 | [
[
[
475,
24,
855
]
],
[
[
475,
21,
28975
],
[
28975,
60,
855
]
],
[
[
475,
24,
407
],
[
407,
63,
855
]
],
[
[
475,
24,
401
],
[
401,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vigabatrin"
]
],
[
[
"Morphine",
"{u} (Compound) causes {v} (Side Effect)",
"Tension"
],
[
"Tension",
"{u} (Side Effect) is caused by {v... | Morphine (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Vigabatrin (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Vigabatrin
Morphine may c... |
DB11978 | DB12130 | 124 | 1,017 | [
"DDInter822",
"DDInter1094"
] | Glasdegib | Lorlatinib | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Major | 2 | [
[
[
124,
25,
1017
]
],
[
[
124,
63,
1612
],
[
1612,
23,
1017
]
],
[
[
124,
63,
786
],
[
786,
24,
1017
]
],
[
[
124,
24,
1421
],
[
1421,
... | [
[
[
"Glasdegib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
]
],
[
[
"Glasdegib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
[
"Fostemsavir... | Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Rilpivirine and Rilpivi... |
DB11703 | DB15091 | 405 | 676 | [
"DDInter9",
"DDInter1901"
] | Acalabrutinib | Upadacitinib | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
405,
25,
676
]
],
[
[
405,
63,
1430
],
[
1430,
24,
676
]
],
[
[
405,
25,
283
],
[
283,
24,
676
]
],
[
[
405,
64,
1593
],
[
1593,
... | [
[
[
"Acalabrutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Acalabrutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"... | Acalabrutinib may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Acalabrutinib may lead to a major life threatening interaction when taken with Fedratinib and Fedratini... |
DB01041 | DB04946 | 770 | 924 | [
"DDInter1789",
"DDInter907"
] | Thalidomide | Iloperidone | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
770,
24,
924
]
],
[
[
770,
63,
1664
],
[
1664,
1,
924
]
],
[
[
770,
63,
1425
],
[
1425,
25,
924
]
],
[
[
770,
24,
519
],
[
519,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Cisapride and Cisapride may lead to a major life threatening int... |
DB00207 | DB12364 | 1,570 | 1,421 | [
"DDInter157",
"DDInter200"
] | Azithromycin | Betrixaban | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
1570,
25,
1421
]
],
[
[
1570,
24,
1151
],
[
1151,
24,
1421
]
],
[
[
1570,
25,
1593
],
[
1593,
24,
1421
]
],
[
[
1570,
63,
305
],
[
305... | [
[
[
"Azithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
],
[
"Sunitin... | Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Azithromycin may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may caus... |
DB00758 | DB01192 | 1,347 | 560 | [
"DDInter413",
"DDInter1372"
] | Clopidogrel | Oxymorphone | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
1347,
24,
560
]
],
[
[
1347,
63,
828
],
[
828,
1,
560
]
],
[
[
1347,
24,
314
],
[
314,
1,
560
]
],
[
[
1347,
6,
8374
],
[
8374,
... | [
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Clopidogrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[
... | Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine (Compound) resembles Oxymorphone (Compound... |
DB00533 | DB01088 | 1,416 | 714 | [
"DDInter1613",
"DDInter908"
] | Rofecoxib | Iloprost | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1416,
24,
714
]
],
[
[
1416,
24,
1479
],
[
1479,
24,
714
]
],
[
[
1416,
63,
1432
],
[
1432,
24,
714
]
],
[
[
1416,
24,
1564
],
[
1564,... | [
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
],
... | Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Abcix... |
DB00304 | DB09046 | 1,657 | 1,094 | [
"DDInter508",
"DDInter1201"
] | Desogestrel | Metreleptin | Desogestrel, a prodrug, is a third generation progestogen and hence, a member of the gonane family which was largely used in Europe before being approved in the US and Canada. It was firstly generated from a study that showed that 11-beta and 11-alkylidene substituent in nortestosterone can enhance the biological activ... | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Moderate | 1 | [
[
[
1657,
24,
1094
]
],
[
[
1657,
24,
1254
],
[
1254,
24,
1094
]
],
[
[
1657,
1,
1197
],
[
1197,
24,
1094
]
],
[
[
1657,
24,
1296
],
[
129... | [
[
[
"Desogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
]
],
[
[
"Desogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]... | Desogestrel may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin
Desogestrel (Compound) resembles Norethisterone (Compound) and Norethisterone may cause a modera... |
DB05773 | DB09061 | 1,047 | 1,627 | [
"DDInter1848",
"DDInter284"
] | Trastuzumab emtansine | Cannabidiol | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
1047,
24,
1627
]
],
[
[
1047,
24,
760
],
[
760,
62,
1627
]
],
[
[
1047,
63,
609
],
[
609,
23,
1627
]
],
[
[
1047,
24,
384
],
[
384,
... | [
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobi... | Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00765 | DB01233 | 1,266 | 1,311 | [
"DDInter1205",
"DDInter1197"
] | Metyrosine | Metoclopramide | An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed) | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
1266,
24,
1311
]
],
[
[
1266,
21,
28714
],
[
28714,
60,
1311
]
],
[
[
1266,
40,
474
],
[
474,
23,
1311
]
],
[
[
1266,
24,
649
],
[
649... | [
[
[
"Metyrosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Metyrosine",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is ca... | Metyrosine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Metoclopramide (Compound)
Metyrosine (Compound) resembles Acetaminophen (Compound) and Acetaminophen may cause a minor interaction that can limit clinical effects when taken with Metoclopramide
Metyrosine may cause a moderate in... |
DB00580 | DB09268 | 311 | 1,662 | [
"DDInter1910",
"DDInter1464"
] | Valdecoxib | Picosulfuric acid | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
311,
24,
1662
]
],
[
[
311,
24,
1619
],
[
1619,
63,
1662
]
],
[
[
311,
63,
91
],
[
91,
24,
1662
]
],
[
[
311,
24,
1573
],
[
1573,
... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and V... |
DB08889 | DB09074 | 350 | 1,362 | [
"DDInter299",
"DDInter1327"
] | Carfilzomib | Olaparib | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
350,
24,
1362
]
],
[
[
350,
63,
896
],
[
896,
24,
1362
]
],
[
[
350,
64,
1336
],
[
1336,
24,
1362
]
],
[
[
350,
24,
1468
],
[
1468,
... | [
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
... | Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Carfilzomib may lead to a major life threatening interaction when taken with Etonogestrel and Etonogestrel may caus... |
DB01009 | DB01097 | 935 | 1,377 | [
"DDInter1009",
"DDInter1033"
] | Ketoprofen | Leflunomide | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
935,
25,
1377
]
],
[
[
935,
6,
6017
],
[
6017,
45,
1377
]
],
[
[
935,
21,
28864
],
[
28864,
60,
1377
]
],
[
[
935,
75,
126
],
[
126,
... | [
[
[
"Ketoprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Ketoprofen",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Leflun... | Ketoprofen (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Ketoprofen (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Leflunomide (Compound)
Ketoprofen (Compound) resembles Warfarin (Compound) and Ketoprofen may lead to a major l... |
DB00078 | DB14783 | 1,172 | 287 | [
"DDInter898",
"DDInter574"
] | Ibritumomab tiuxetan | Diroximel fumarate | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
1172,
24,
287
]
],
[
[
1172,
24,
384
],
[
384,
24,
287
]
],
[
[
1172,
25,
1468
],
[
1468,
24,
287
]
],
[
[
1172,
63,
1184
],
[
1184,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Ponatini... |
DB01410 | DB08873 | 423 | 74 | [
"DDInter376",
"DDInter221"
] | Ciclesonide (nasal) | Boceprevir | Ciclesonide is an organic molecular entity. | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Moderate | 1 | [
[
[
423,
24,
74
]
],
[
[
423,
6,
8374
],
[
8374,
45,
74
]
],
[
[
423,
21,
28792
],
[
28792,
60,
74
]
],
[
[
423,
63,
86
],
[
86,
24,... | [
[
[
"Ciclesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Boceprevir"
]
],
[
[
"Ciclesonide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Ciclesonide may cause a moderate interaction that could exacerbate diseases when taken with Boceprevir
Ciclesonide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Boceprevir (Compound)
Ciclesonide (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is cause... |
DB00390 | DB08895 | 1,252 | 976 | [
"DDInter554",
"DDInter1825"
] | Digoxin | Tofacitinib | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
1252,
24,
976
]
],
[
[
1252,
24,
660
],
[
660,
24,
976
]
],
[
[
1252,
24,
214
],
[
214,
63,
976
]
],
[
[
1252,
1,
1482
],
[
1482,
... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esomeprazole"
],
[
... | Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fosta... |
DB05294 | DB05351 | 1,069 | 101 | [
"DDInter1917",
"DDInter519"
] | Vandetanib | Dexlansoprazole | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Minor | 0 | [
[
[
1069,
23,
101
]
],
[
[
1069,
64,
609
],
[
609,
24,
101
]
],
[
[
1069,
1,
883
],
[
883,
24,
101
]
],
[
[
1069,
63,
1252
],
[
1252,
... | [
[
[
"Vandetanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Cla... | Vandetanib may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Dexlansoprazole
Vandetanib (Compound) resembles Gefitinib (Compound) and Gefitinib may cause a moderate interaction that could exa... |
DB00619 | DB09048 | 1,419 | 555 | [
"DDInter909",
"DDInter1284"
] | Imatinib | Netupitant | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Moderate | 1 | [
[
[
1419,
24,
555
]
],
[
[
1419,
62,
1101
],
[
1101,
23,
555
]
],
[
[
1419,
24,
466
],
[
466,
62,
555
]
],
[
[
1419,
63,
254
],
[
254,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
]
],
[
[
"Imatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
"B... | Imatinib may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Netupitant
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide... |
DB00773 | DB14711 | 896 | 779 | [
"DDInter702",
"DDInter1680"
] | Etoposide | Smallpox (Vaccinia) Vaccine, Live | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
896,
25,
779
]
],
[
[
896,
64,
1064
],
[
1064,
25,
779
]
],
[
[
896,
24,
478
],
[
478,
25,
779
]
],
[
[
896,
25,
1377
],
[
1377,
... | [
[
[
"Etoposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Etoposide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Clad... | Etoposide may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may le... |
DB01217 | DB04574 | 630 | 177 | [
"DDInter95",
"DDInter684"
] | Anastrozole | Estrone sulfate (topical) | Anastrozole is a non-steroidal aromatase inhibitor (AI), similar to [letrozole], used to decrease circulating estrogen levels in the treatment of postmenopausal women with estrogen-responsive breast cancer. Anastrozole is also related to [exemestane], a steroidal AI, but its non-steroidal nature provides stark advantag... | Estrone 3-sulfate is a steroid sulfate that is the 3-sulfate of estrone. It has a role as a human metabolite and a mouse metabolite. It is a 17-oxo steroid and a steroid sulfate. It is functionally related to an estrone. It is a conjugate acid of an estrone 3-sulfate(1-). It derives from a hydride of an estrane. | Moderate | 1 | [
[
[
630,
24,
177
]
],
[
[
630,
63,
380
],
[
380,
1,
177
]
],
[
[
630,
24,
35
],
[
35,
1,
177
]
],
[
[
630,
6,
7950
],
[
7950,
45,
... | [
[
[
"Anastrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estrone sulfate"
]
],
[
[
"Anastrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conjugated estrogens... | Anastrozole may cause a moderate interaction that could exacerbate diseases when taken with Estrone sulfate
Anastrozole may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens and Conjugated estrogens (Compound) resembles Estrone sulfate (Compound)
Anastrozole may cause a mo... |
DB00009 | DB00407 | 1,271 | 202 | [
"DDInter56",
"DDInter115"
] | Alteplase | Ardeparin | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with... | Major | 2 | [
[
[
1271,
25,
202
]
],
[
[
1271,
24,
738
],
[
738,
63,
202
]
],
[
[
1271,
24,
1595
],
[
1595,
24,
202
]
],
[
[
1271,
25,
1564
],
[
1564,
... | [
[
[
"Alteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ardeparin"
]
],
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
[
"Niraparib",
... | Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Ardeparin
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Collagenase clostridium hi... |
DB00108 | DB04845 | 1,066 | 309 | [
"DDInter1268",
"DDInter1001"
] | Natalizumab | Ixabepilone | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Major | 2 | [
[
[
1066,
25,
309
]
],
[
[
1066,
25,
60
],
[
60,
23,
309
]
],
[
[
1066,
25,
1419
],
[
1419,
24,
309
]
],
[
[
1066,
25,
1619
],
[
1619,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixabepilone"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Capecitabine"
],
[
"Capecitabine",
... | Natalizumab may lead to a major life threatening interaction when taken with Capecitabine and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Ixabepilone
Natalizumab may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a moderate int... |
DB00916 | DB01159 | 112 | 419 | [
"DDInter1202",
"DDInter854"
] | Metronidazole | Halothane | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Minor | 0 | [
[
[
112,
23,
419
]
],
[
[
112,
6,
8374
],
[
8374,
45,
419
]
],
[
[
112,
23,
774
],
[
774,
63,
419
]
],
[
[
112,
23,
1264
],
[
1264,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Halothane"
]
],
[
[
"Metronidazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Metronidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Halothane (Compound)
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Degarelix and Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Halothane
Metronidazole may ... |
DB00813 | DB06274 | 704 | 574 | [
"DDInter722",
"DDInter59"
] | Fentanyl | Alvimopan | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Alvimopan is a peripherally acting μ opioid antagonist. It is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period. | Major | 2 | [
[
[
704,
25,
574
]
],
[
[
704,
1,
1055
],
[
1055,
40,
574
]
],
[
[
704,
6,
6291
],
[
6291,
45,
574
]
],
[
[
704,
21,
28759
],
[
28759,
... | [
[
[
"Fentanyl",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alvimopan"
]
],
[
[
"Fentanyl",
"{u} (Compound) resembles {v} (Compound)",
"Benazepril"
],
[
"Benazepril",
"{u} (Compound) resembles {v} (Compound)",
... | Fentanyl (Compound) resembles Benazepril (Compound) and Benazepril (Compound) resembles Alvimopan (Compound)
Fentanyl (Compound) binds OPRD1 (Gene) and OPRD1 (Gene) is bound by Alvimopan (Compound)
Fentanyl (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused... |
DB00835 | DB01403 | 100 | 9 | [
"DDInter245",
"DDInter1175"
] | Brompheniramine | Methotrimeprazine | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
100,
24,
9
]
],
[
[
100,
63,
1178
],
[
1178,
40,
9
]
],
[
[
100,
63,
1164
],
[
1164,
1,
9
]
],
[
[
100,
24,
104
],
[
104,
40,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoper... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) r... |
DB00757 | DB11796 | 1,166 | 1,612 | [
"DDInter581",
"DDInter786"
] | Dolasetron | Fostemsavir | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Major | 2 | [
[
[
1166,
25,
1612
]
],
[
[
1166,
24,
98
],
[
98,
23,
1612
]
],
[
[
1166,
23,
112
],
[
112,
23,
1612
]
],
[
[
1166,
64,
1424
],
[
1424,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
]
],
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
],
[
"Somatrem",
... | Dolasetron may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Dolasetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidaz... |
DB00078 | DB08904 | 1,172 | 375 | [
"DDInter898",
"DDInter342"
] | Ibritumomab tiuxetan | Certolizumab pegol | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
1172,
25,
375
]
],
[
[
1172,
24,
200
],
[
200,
63,
375
]
],
[
[
1172,
24,
66
],
[
66,
24,
375
]
],
[
[
1172,
25,
792
],
[
792,
2... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albica... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans and Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseas... |
DB00285 | DB08868 | 1,100 | 1,011 | [
"DDInter1927",
"DDInter737"
] | Venlafaxine | Fingolimod | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1100,
25,
1011
]
],
[
[
1100,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
1100,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
1100,
24,
578
],
[
... | [
[
[
"Venlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Venlafaxine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Fingo... | Venlafaxine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Venlafaxine (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Ticagr... |
DB01234 | DB05316 | 1,220 | 749 | [
"DDInter513",
"DDInter1467"
] | Dexamethasone | Pimavanserin | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Moderate | 1 | [
[
[
1220,
24,
749
]
],
[
[
1220,
24,
392
],
[
392,
24,
749
]
],
[
[
1220,
63,
888
],
[
888,
24,
749
]
],
[
[
1220,
25,
594
],
[
594,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimavanserin"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Pimavanserin
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and T... |
DB00332 | DB00771 | 1,089 | 262 | [
"DDInter970",
"DDInter397"
] | Ipratropium | Clidinium | Ipratropium is a quaternary ammonium derivative of [atropine] that acts as an anticholinergic agent. It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its... | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Moderate | 1 | [
[
[
1089,
24,
262
]
],
[
[
1089,
24,
1511
],
[
1511,
63,
262
]
],
[
[
1089,
6,
2720
],
[
2720,
45,
262
]
],
[
[
1089,
35,
19
],
[
19,
... | [
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clidinium"
]
],
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Ipratropium (Compound) binds CHRM3 (Gene) and CHRM3 (Gene) is bound by Clidinium (Compound)
Ipratropium (Compo... |
DB00283 | DB00726 | 701 | 1,164 | [
"DDInter395",
"DDInter1876"
] | Clemastine | Trimipramine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Moderate | 1 | [
[
[
701,
24,
1164
]
],
[
[
701,
24,
1237
],
[
1237,
40,
1164
]
],
[
[
701,
25,
675
],
[
675,
40,
1164
]
],
[
[
701,
6,
10104
],
[
10104,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Trimipramine (Compound)
Clemastine may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Trimipramine (C... |
DB00099 | DB15699 | 440 | 652 | [
"DDInter735",
"DDInter232"
] | Filgrastim | Brexucabtagene autoleucel | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as [ibrutinib] and [acalabrutinib], the prognosis for MCL patients rem... | Moderate | 1 | [
[
[
440,
24,
652
]
],
[
[
440,
24,
4
],
[
4,
24,
652
]
],
[
[
440,
63,
599
],
[
599,
24,
652
]
],
[
[
440,
25,
1064
],
[
1064,
25,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexucabtagene autoleucel"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine ... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Brexucabtagene autoleucel
Filgrastim may cause a moderate interaction that could exacerbate d... |
DB00431 | DB00679 | 1,503 | 684 | [
"DDInter1072",
"DDInter1796"
] | Lindane | Thioridazine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Moderate | 1 | [
[
[
1503,
24,
684
]
],
[
[
1503,
24,
1237
],
[
1237,
40,
684
]
],
[
[
1503,
24,
216
],
[
216,
1,
684
]
],
[
[
1503,
63,
508
],
[
508,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Thioridazine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) resembles Thioridazine (... |
DB01344 | DB01592 | 1,231 | 1,596 | [
"DDInter1830",
"DDInter975"
] | Tolevamer | Iron | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Moderate | 1 | [
[
[
1231,
24,
1596
]
],
[
[
1231,
24,
1193
],
[
1193,
62,
1596
]
],
[
[
1231,
63,
1215
],
[
1215,
24,
1596
]
],
[
[
1231,
25,
1384
],
[
13... | [
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
]
],
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
],
[
... | Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Iron
Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansop... |
DB01073 | DB01165 | 1,488 | 1,539 | [
"DDInter745",
"DDInter1325"
] | Fludarabine | Ofloxacin | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Minor | 0 | [
[
[
1488,
23,
1539
]
],
[
[
1488,
62,
1467
],
[
1467,
1,
1539
]
],
[
[
1488,
23,
945
],
[
945,
40,
1539
]
],
[
[
1488,
62,
956
],
[
956,
... | [
[
[
"Fludarabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ofloxacin"
]
],
[
[
"Fludarabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enoxacin"
],
[
"... | Fludarabine may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Fludarabine may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Flud... |
DB00726 | DB00857 | 1,164 | 1,387 | [
"DDInter1876",
"DDInter1768"
] | Trimipramine | Terbinafine | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Moderate | 1 | [
[
[
1164,
24,
1387
]
],
[
[
1164,
6,
8374
],
[
8374,
45,
1387
]
],
[
[
1164,
7,
6134
],
[
6134,
45,
1387
]
],
[
[
1164,
7,
4634
],
[
4634,... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terbinafine"
]
],
[
[
"Trimipramine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Trimipramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Terbinafine (Compound)
Trimipramine (Compound) upregulates SQLE (Gene) and SQLE (Gene) is bound by Terbinafine (Compound)
Trimipramine (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Terbinafine (Compound)
Trimipramine (Com... |
DB00476 | DB04951 | 109 | 187 | [
"DDInter608",
"DDInter1477"
] | Duloxetine | Pirfenidone | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Moderate | 1 | [
[
[
109,
24,
187
]
],
[
[
109,
25,
1670
],
[
1670,
63,
187
]
],
[
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109,
24,
1419
],
[
1419,
24,
187
]
],
[
[
109,
63,
702
],
[
702,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pirfenidone"
]
],
[
[
"Duloxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eliglustat"
],
[
"Eliglusta... | Duloxetine may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Pirfenidone
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a m... |
DB00163 | DB06605 | 1,461 | 1,409 | [
"DDInter1943",
"DDInter108"
] | Vitamin E | Apixaban | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
1461,
24,
1409
]
],
[
[
1461,
62,
58
],
[
58,
24,
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],
[
[
1461,
23,
1531
],
[
1531,
24,
1409
]
],
[
[
1461,
23,
1093
],
[
1093,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Alefacept"
],
[
"Al... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Apixaban
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Canakinumab and Canakinumab may... |
DB01320 | DB11730 | 651 | 351 | [
"DDInter783",
"DDInter1588"
] | Fosphenytoin | Ribociclib | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
651,
25,
351
]
],
[
[
651,
25,
466
],
[
466,
62,
351
]
],
[
[
651,
63,
112
],
[
112,
23,
351
]
],
[
[
651,
24,
310
],
[
310,
24,... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Darolutamide"
],
[
"Darolutamide",
... | Fosphenytoin may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazol... |
DB00495 | DB01177 | 139 | 77 | [
"DDInter1961",
"DDInter904"
] | Zidovudine | Idarubicin | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
139,
24,
77
]
],
[
[
139,
6,
6017
],
[
6017,
45,
77
]
],
[
[
139,
6,
5441
],
[
5441,
46,
77
]
],
[
[
139,
21,
29170
],
[
29170,
... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Zidovudine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",... | Zidovudine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Zidovudine (Compound) binds TERT (Gene) and TERT (Gene) is upregulated by Idarubicin (Compound)
Zidovudine (Compound) causes Cardiac failure congestive (Side Effect) and Cardiac failure congestive (Side Effect) is caused by Id... |
DB00762 | DB01118 | 613 | 33 | [
"DDInter973",
"DDInter76"
] | Irinotecan | Amiodarone | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
613,
24,
33
]
],
[
[
613,
24,
540
],
[
540,
1,
33
]
],
[
[
613,
6,
6799
],
[
6799,
45,
33
]
],
[
[
613,
18,
11048
],
[
11048,
46... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
],
[
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Irinotecan (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Amiodarone (Compound)
Irinotecan (Compound) downregulates VAT1 (Gene) and VAT1 (Gene) ... |
DB00661 | DB06791 | 122 | 1,446 | [
"DDInter1928",
"DDInter1021"
] | Verapamil | Lanreotide | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Moderate | 1 | [
[
[
122,
24,
1446
]
],
[
[
122,
23,
466
],
[
466,
62,
1446
]
],
[
[
122,
24,
1017
],
[
1017,
63,
1446
]
],
[
[
122,
25,
405
],
[
405,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanreotide"
]
],
[
[
"Verapamil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
... | Verapamil may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Lanreotide
Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatin... |
DB00046 | DB09045 | 1,179 | 52 | [
"DDInter940",
"DDInter607"
] | Insulin lispro | Dulaglutide | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
1179,
24,
52
]
],
[
[
1179,
23,
1103
],
[
1103,
23,
52
]
],
[
[
1179,
24,
170
],
[
170,
23,
52
]
],
[
[
1179,
24,
280
],
[
280,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Insulin lispro",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Insulin lispro may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and ... |
DB06402 | DB08875 | 1,079 | 1,618 | [
"DDInter1756",
"DDInter262"
] | Telavancin | Cabozantinib | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1079,
25,
1618
]
],
[
[
1079,
62,
112
],
[
112,
23,
1618
]
],
[
[
1079,
24,
1662
],
[
1662,
63,
1618
]
],
[
[
1079,
63,
480
],
[
480,
... | [
[
[
"Telavancin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Telavancin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Telavancin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid... |
DB08875 | DB09082 | 1,618 | 659 | [
"DDInter262",
"DDInter1934"
] | Cabozantinib | Vilanterol | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1618,
24,
659
]
],
[
[
1618,
63,
1220
],
[
1220,
23,
659
]
],
[
[
1618,
64,
1570
],
[
1570,
24,
659
]
],
[
[
1618,
25,
927
],
[
927,
... | [
[
[
"Cabozantinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Cabozantinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Cabozantinib may lead to a major life threatening interaction when taken with Azithromycin and Azithromyci... |
DB08908 | DB14443 | 713 | 987 | [
"DDInter564",
"DDInter1931"
] | Dimethyl fumarate | Vibrio cholerae CVD 103-HgR strain live antigen | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
713,
24,
987
]
],
[
[
713,
24,
1480
],
[
1480,
24,
987
]
],
[
[
713,
63,
141
],
[
141,
24,
987
]
],
[
[
713,
64,
581
],
[
581,
2... | [
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when ... | Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Dimethyl fumarate may cause a moderate interaction that could exacerbate... |
DB01229 | DB06372 | 973 | 259 | [
"DDInter1377",
"DDInter1594"
] | Paclitaxel | Rilonacept | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
973,
24,
259
]
],
[
[
973,
63,
1461
],
[
1461,
23,
259
]
],
[
[
973,
24,
1619
],
[
1619,
63,
259
]
],
[
[
973,
24,
478
],
[
478,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib m... |
DB00425 | DB14723 | 558 | 159 | [
"DDInter1970",
"DDInter1026"
] | Zolpidem | Larotrectinib | Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of s... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
558,
24,
159
]
],
[
[
558,
24,
222
],
[
222,
23,
159
]
],
[
[
558,
24,
98
],
[
98,
24,
159
]
],
[
[
558,
63,
353
],
[
353,
24,
... | [
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem ... |
DB06081 | DB15035 | 1,046 | 503 | [
"DDInter286",
"DDInter1959"
] | Caplacizumab | Zanubrutinib | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1046,
25,
503
]
],
[
[
1046,
63,
222
],
[
222,
24,
503
]
],
[
[
1046,
24,
738
],
[
738,
24,
503
]
],
[
[
1046,
25,
39
],
[
39,
2... | [
[
[
"Caplacizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Caplacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sib... | Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and... |
DB00446 | DB01320 | 597 | 651 | [
"DDInter351",
"DDInter783"
] | Chloramphenicol | Fosphenytoin | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
597,
24,
651
]
],
[
[
597,
23,
307
],
[
307,
1,
651
]
],
[
[
597,
63,
362
],
[
362,
1,
651
]
],
[
[
597,
6,
6017
],
[
6017,
45,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Chloramphenicol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],... | Chloramphenicol may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Fosphenytoin (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Co... |
DB00008 | DB00980 | 491 | 969 | [
"DDInter1407",
"DDInter1564"
] | Peginterferon alfa-2a | Ramelteon | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Moderate | 1 | [
[
[
491,
24,
969
]
],
[
[
491,
25,
1101
],
[
1101,
24,
969
]
],
[
[
491,
24,
702
],
[
702,
24,
969
]
],
[
[
491,
24,
384
],
[
384,
6... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ramelteon"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
... | Peginterferon alfa-2a may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Ramelteon
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Anagrelide and ... |
DB00414 | DB04946 | 590 | 924 | [
"DDInter16",
"DDInter907"
] | Acetohexamide | Iloperidone | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
590,
24,
924
]
],
[
[
590,
24,
1664
],
[
1664,
1,
924
]
],
[
[
590,
24,
519
],
[
519,
40,
924
]
],
[
[
590,
24,
1532
],
[
1532,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Iloperido... |
DB00557 | DB01233 | 252 | 1,311 | [
"DDInter895",
"DDInter1197"
] | Hydroxyzine | Metoclopramide | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
252,
24,
1311
]
],
[
[
252,
24,
1151
],
[
1151,
40,
1311
]
],
[
[
252,
25,
1425
],
[
1425,
40,
1311
]
],
[
[
252,
6,
12523
],
[
12523,... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
],
... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib (Compound) resembles Metoclopramide (Compound)
Hydroxyzine may lead to a major life threatening interaction when taken with Cisapride and Cisapride (Compound) resembles Metoclopramide (Compound)
Hydroxyzi... |
DB00307 | DB01045 | 1,101 | 463 | [
"DDInter202",
"DDInter1590"
] | Bexarotene | Rifampicin | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Minor | 0 | [
[
[
1101,
23,
463
]
],
[
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690
],
[
690,
40,
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[
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],
[
[
1101,
62,
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[
608,
... | [
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rifampicin"
]
],
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rifabutin"
],
[
"... | Bexarotene may cause a minor interaction that can limit clinical effects when taken with Rifabutin and Rifabutin (Compound) resembles Rifampicin (Compound)
Bexarotene (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Rifampicin (Compound)
Bexarotene may cause a minor interaction that can limit clinical effec... |
DB00307 | DB00497 | 1,101 | 828 | [
"DDInter202",
"DDInter1366"
] | Bexarotene | Oxycodone | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Moderate | 1 | [
[
[
1101,
24,
828
]
],
[
[
1101,
24,
267
],
[
267,
64,
828
]
],
[
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1101,
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8374
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[
8374,
45,
828
]
],
[
[
1101,
21,
29094
],
[
29094,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may lead to a major life threatening interaction when taken with Oxycodone
Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Oxycodone (Compound)
Bexarotene (Compound) causes Thinki... |
DB00682 | DB14575 | 126 | 733 | [
"DDInter1951",
"DDInter674"
] | Warfarin | Eslicarbazepine | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
126,
24,
733
]
],
[
[
126,
62,
168
],
[
168,
23,
733
]
],
[
[
126,
24,
1264
],
[
1264,
24,
733
]
],
[
[
126,
23,
477
],
[
477,
2... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[
... | Warfarin may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may ... |
DB00222 | DB06292 | 245 | 549 | [
"DDInter825",
"DDInter474"
] | Glimepiride | Dapagliflozin | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
245,
24,
549
]
],
[
[
245,
24,
1344
],
[
1344,
40,
549
]
],
[
[
245,
6,
6017
],
[
6017,
45,
549
]
],
[
[
245,
21,
29222
],
[
29222,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dapagliflozin (Compound)
Glimepiride (Compound) causes Hypoglycaemia (Side Ef... |
DB00545 | DB11921 | 751 | 1,019 | [
"DDInter1548",
"DDInter492"
] | Pyridostigmine | Deflazacort | Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of ... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
751,
24,
1019
]
],
[
[
751,
24,
61
],
[
61,
24,
1019
]
],
[
[
751,
40,
1372
],
[
1372,
24,
1019
]
],
[
[
751,
24,
1220
],
[
1220,
... | [
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edrophonium"
]... | Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Edrophonium and Edrophonium may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Pyridostigmine (Compound) resembles Neostigmine (Compound) and Neostigmine may cause a moderate interacti... |
DB00443 | DB01080 | 251 | 855 | [
"DDInter195",
"DDInter1933"
] | Betamethasone | Vigabatrin | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Major | 2 | [
[
[
251,
25,
855
]
],
[
[
251,
21,
28719
],
[
28719,
60,
855
]
],
[
[
251,
25,
770
],
[
770,
24,
855
]
],
[
[
251,
1,
617
],
[
617,
... | [
[
[
"Betamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vigabatrin"
]
],
[
[
"Betamethasone",
"{u} (Compound) causes {v} (Side Effect)",
"Pain"
],
[
"Pain",
"{u} (Side Effect) is caused by {v} (Compound... | Betamethasone (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Vigabatrin (Compound)
Betamethasone may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Vigabatrin
Betamethasone... |
DB00687 | DB08908 | 870 | 713 | [
"DDInter747",
"DDInter564"
] | Fludrocortisone | Dimethyl fumarate | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
870,
24,
713
]
],
[
[
870,
24,
4
],
[
4,
24,
713
]
],
[
[
870,
24,
270
],
[
270,
63,
713
]
],
[
[
870,
1,
1220
],
[
1220,
24,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxin... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Fludrocortisone may cause a moderate interaction that could exacerbate... |
DB00607 | DB00619 | 1,249 | 1,419 | [
"DDInter1256",
"DDInter909"
] | Nafcillin | Imatinib | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
1249,
24,
1419
]
],
[
[
1249,
6,
7950
],
[
7950,
45,
1419
]
],
[
[
1249,
7,
3422
],
[
3422,
46,
1419
]
],
[
[
1249,
21,
28766
],
[
287... | [
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Nafcillin",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Nafcillin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Imatinib (Compound)
Nafcillin (Compound) upregulates SATB1 (Gene) and SATB1 (Gene) is upregulated by Imatinib (Compound)
Nafcillin (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Imatinib (Compound)
Nafcillin m... |
DB11703 | DB11901 | 405 | 913 | [
"DDInter9",
"DDInter107"
] | Acalabrutinib | Apalutamide | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
405,
25,
913
]
],
[
[
405,
64,
279
],
[
279,
24,
913
]
],
[
[
405,
63,
1237
],
[
1237,
24,
913
]
],
[
[
405,
24,
1320
],
[
1320,
... | [
[
[
"Acalabrutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Acalabrutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anisindione"
],
[
"Anisindione",
... | Acalabrutinib may lead to a major life threatening interaction when taken with Anisindione and Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Acalabrutinib may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomiprami... |
DB00496 | DB09076 | 194 | 1,116 | [
"DDInter480",
"DDInter1899"
] | Darifenacin | Umeclidinium | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
194,
24,
1116
]
],
[
[
194,
24,
849
],
[
849,
24,
1116
]
],
[
[
194,
63,
128
],
[
128,
24,
1116
]
],
[
[
194,
74,
352
],
[
352,
... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramin... |
DB00912 | DB09045 | 473 | 52 | [
"DDInter1581",
"DDInter607"
] | Repaglinide | Dulaglutide | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
473,
24,
52
]
],
[
[
473,
62,
1103
],
[
1103,
23,
52
]
],
[
[
473,
24,
170
],
[
170,
23,
52
]
],
[
[
473,
24,
280
],
[
280,
24,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Repaglinide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
[
... | Repaglinide may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagl... |
DB01149 | DB11730 | 851 | 351 | [
"DDInter1274",
"DDInter1588"
] | Nefazodone | Ribociclib | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
851,
25,
351
]
],
[
[
851,
23,
466
],
[
466,
62,
351
]
],
[
[
851,
64,
222
],
[
222,
23,
351
]
],
[
[
851,
25,
283
],
[
283,
62,... | [
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Nefazodone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[
"Darolutami... | Nefazodone may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Nefazodone may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may caus... |
DB01406 | DB06292 | 984 | 549 | [
"DDInter472",
"DDInter474"
] | Danazol | Dapagliflozin | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
984,
24,
549
]
],
[
[
984,
24,
1344
],
[
1344,
40,
549
]
],
[
[
984,
6,
8374
],
[
8374,
45,
549
]
],
[
[
984,
21,
28882
],
[
28882,
... | [
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
[
... | Danazol may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Danazol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Danazol (Compound) causes Body temperature increased (Side E... |
DB01124 | DB09045 | 1,411 | 52 | [
"DDInter1828",
"DDInter607"
] | Tolbutamide | Dulaglutide | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
1411,
24,
52
]
],
[
[
1411,
62,
1103
],
[
1103,
23,
52
]
],
[
[
1411,
24,
170
],
[
170,
23,
52
]
],
[
[
1411,
24,
280
],
[
280,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Tolbutamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
[
... | Tolbutamide may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagl... |
DB01069 | DB06663 | 401 | 1,154 | [
"DDInter1533",
"DDInter1398"
] | Promethazine | Pasireotide | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
401,
25,
1154
]
],
[
[
401,
21,
29355
],
[
29355,
60,
1154
]
],
[
[
401,
62,
112
],
[
112,
23,
1154
]
],
[
[
401,
24,
1385
],
[
1385,
... | [
[
[
"Promethazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Promethazine",
"{u} (Compound) causes {v} (Side Effect)",
"Injection site reaction"
],
[
"Injection site reaction",
"{u} (Si... | Promethazine (Compound) causes Injection site reaction (Side Effect) and Injection site reaction (Side Effect) is caused by Pasireotide (Compound)
Promethazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clini... |
DB00757 | DB01192 | 1,166 | 560 | [
"DDInter581",
"DDInter1372"
] | Dolasetron | Oxymorphone | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
1166,
24,
560
]
],
[
[
1166,
63,
828
],
[
828,
1,
560
]
],
[
[
1166,
24,
314
],
[
314,
1,
560
]
],
[
[
1166,
6,
12523
],
[
12523,
... | [
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[
... | Dolasetron may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Dolasetron may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine (Compound) resembles Oxymorphone (Compound)
... |
DB09278 | DB14006 | 852 | 972 | [
"DDInter24",
"DDInter370"
] | Activated charcoal | Choline salicylate | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
852,
24,
972
]
],
[
[
852,
63,
126
],
[
126,
24,
972
]
],
[
[
852,
63,
1510
],
[
1510,
25,
972
]
],
[
[
852,
63,
126
],
[
126,
2... | [
[
[
"Activated charcoal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Activated charcoal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"War... | Activated charcoal may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Activated charcoal may cause a moderate interaction that could exacerbate diseases when taken with T... |
DB06186 | DB08860 | 1,439 | 788 | [
"DDInter969",
"DDInter1479"
] | Ipilimumab | Pitavastatin | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
1439,
24,
788
]
],
[
[
1439,
63,
671
],
[
671,
1,
788
]
],
[
[
1439,
63,
700
],
[
700,
40,
788
]
],
[
[
1439,
64,
126
],
[
126,
... | [
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
[... | Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastatin (Compound) resembles Pitavastatin (... |
DB08880 | DB15762 | 1,510 | 725 | [
"DDInter1771",
"DDInter1644"
] | Teriflunomide | Satralizumab | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare au... | Major | 2 | [
[
[
1510,
25,
725
]
],
[
[
1510,
23,
1193
],
[
1193,
23,
725
]
],
[
[
1510,
25,
1362
],
[
1362,
24,
725
]
],
[
[
1510,
64,
372
],
[
372,
... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Satralizumab"
]
],
[
[
"Teriflunomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"... | Teriflunomide may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Satralizumab
Teriflunomide may lead to a major life threatening interaction when taken with Olaparib and Olaparib ma... |
DB00193 | DB09122 | 534 | 1,613 | [
"DDInter1841",
"DDInter1409"
] | Tramadol | Peginterferon beta-1a | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Major | 2 | [
[
[
534,
25,
1613
]
],
[
[
534,
24,
600
],
[
600,
24,
1613
]
],
[
[
534,
25,
1503
],
[
1503,
24,
1613
]
],
[
[
534,
24,
1383
],
[
1383,
... | [
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
"Fl... | Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Tramadol may lead to a major life threatening interaction when taken with Lindane and Lindane may cau... |
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