drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00218 | DB00741 | 1,176 | 167 | [
"DDInter1247",
"DDInter885"
] | Moxifloxacin | Hydrocortisone | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Major | 2 | [
[
[
1176,
25,
167
]
],
[
[
1176,
25,
1220
],
[
1220,
40,
167
]
],
[
[
1176,
25,
870
],
[
870,
1,
167
]
],
[
[
1176,
21,
28642
],
[
28642,
... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
],
[
"Dexamethasone"... | Moxifloxacin may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Moxifloxacin may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Hydrocortisone (Compound)
Mo... |
DB00582 | DB11995 | 1,622 | 1,634 | [
"DDInter1946",
"DDInter143"
] | Voriconazole | Avatrombopag | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Avatrombopag (_Doptelet_), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,[A33097,L2824] thereby decreasing the need for blood transfusions. Patients with thrombocytopenia and chronic liver disease often require pla... | Moderate | 1 | [
[
[
1622,
24,
1634
]
],
[
[
1622,
24,
760
],
[
760,
24,
1634
]
],
[
[
1622,
63,
254
],
[
254,
24,
1634
]
],
[
[
1622,
25,
971
],
[
971,
... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avatrombopag"
]
],
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
],
... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Avatrombopag
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Nitisinone and ... |
DB00352 | DB06186 | 482 | 1,439 | [
"DDInter1814",
"DDInter969"
] | Tioguanine | Ipilimumab | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Moderate | 1 | [
[
[
482,
24,
1439
]
],
[
[
482,
63,
912
],
[
912,
24,
1439
]
],
[
[
482,
24,
1412
],
[
1412,
63,
1439
]
],
[
[
482,
24,
267
],
[
267,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon beta-1a"
],
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Calas... |
DB00539 | DB06206 | 11 | 1,268 | [
"DDInter1837",
"DDInter1719"
] | Toremifene | Sugammadex | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general ane... | Moderate | 1 | [
[
[
11,
24,
1268
]
],
[
[
11,
24,
279
],
[
279,
24,
1268
]
],
[
[
11,
24,
279
],
[
279,
64,
291
],
[
291,
24,
1268
]
],
[
[
11,
25,
... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sugammadex"
]
],
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"
],
[
... | Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Sugammadex
Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Ani... |
DB00067 | DB01128 | 317 | 918 | [
"DDInter1921",
"DDInter204"
] | Vasopressin | Bicalutamide | Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour.[A110, A111, A112, A113, A228008] Vasopressin is very similar to oxytocin, differing in the third an... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
317,
24,
918
]
],
[
[
317,
24,
129
],
[
129,
40,
918
]
],
[
[
317,
23,
112
],
[
112,
23,
918
]
],
[
[
317,
24,
392
],
[
392,
63,... | [
[
[
"Vasopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Vasopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Vasopressin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Vasopressin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction t... |
DB01114 | DB04837 | 272 | 649 | [
"DDInter362",
"DDInter407"
] | Chlorpheniramine | Clofedanol | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
272,
24,
649
]
],
[
[
272,
74,
1376
],
[
1376,
24,
649
]
],
[
[
272,
63,
21
],
[
21,
24,
649
]
],
[
[
272,
64,
675
],
[
675,
40,... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Chlorpheniramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases ... | Chlorpheniramine (Compound) resembles Diphenhydramine (Compound) and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Chlorpheniramine may cause ... |
DB00047 | DB00609 | 176 | 595 | [
"DDInter932",
"DDInter694"
] | Insulin glargine | Ethionamide | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | Moderate | 1 | [
[
[
176,
24,
595
]
],
[
[
176,
24,
1487
],
[
1487,
63,
595
]
],
[
[
176,
63,
305
],
[
305,
24,
595
]
],
[
[
176,
24,
168
],
[
168,
2... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethionamide"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroq... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide
Insulin glargine may cause a moderate interaction that could exacerbate diseases when tak... |
DB12825 | DB14723 | 1,375 | 159 | [
"DDInter1032",
"DDInter1026"
] | Lefamulin | Larotrectinib | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1375,
24,
159
]
],
[
[
1375,
63,
222
],
[
222,
23,
159
]
],
[
[
1375,
63,
741
],
[
741,
24,
159
]
],
[
[
1375,
64,
1181
],
[
1181,
... | [
[
[
"Lefamulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Lefamulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Lefamulin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Lefamulin may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolap... |
DB01069 | DB01244 | 401 | 762 | [
"DDInter1533",
"DDInter192"
] | Promethazine | Bepridil | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Major | 2 | [
[
[
401,
25,
762
]
],
[
[
401,
24,
1376
],
[
1376,
24,
762
]
],
[
[
401,
63,
704
],
[
704,
1,
762
]
],
[
[
401,
63,
832
],
[
832,
40... | [
[
[
"Promethazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bepridil"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[
"Dip... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Bepridil
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl ... |
DB00041 | DB00445 | 1,648 | 322 | [
"DDInter38",
"DDInter655"
] | Aldesleukin | Epirubicin | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
1648,
24,
322
]
],
[
[
1648,
23,
646
],
[
646,
62,
322
]
],
[
[
1648,
24,
1307
],
[
1307,
62,
322
]
],
[
[
1648,
24,
1224
],
[
1224,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Aldesleukin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cinoxacin"
],
[
... | Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Cinoxacin and Cinoxacin may cause a minor interaction that can limit clinical effects when taken with Epirubicin
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan m... |
DB00373 | DB09333 | 461 | 278 | [
"DDInter1809",
"DDInter963"
] | Timolol | Iopodic acid | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Iopodic acid, also known by the name of ipodate, is classified as a cholecystographic agent formed by a weak organic acid that contains a tri-iodinated benzene ring with iodine at positions 2, 4 and 6. Due to its particular structure, it presents a high degree of lipid solubility and a radiopaque property. It was devel... | Moderate | 1 | [
[
[
461,
24,
278
]
],
[
[
461,
63,
1648
],
[
1648,
24,
278
]
],
[
[
461,
24,
1527
],
[
1527,
24,
278
]
],
[
[
461,
1,
668
],
[
668,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopodic acid"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid and Iot... |
DB00377 | DB04953 | 1,494 | 495 | [
"DDInter1382",
"DDInter708"
] | Palonosetron | Ezogabine | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Moderate | 1 | [
[
[
1494,
24,
495
]
],
[
[
1494,
21,
28787
],
[
28787,
60,
495
]
],
[
[
1494,
23,
112
],
[
112,
23,
495
]
],
[
[
1494,
24,
1148
],
[
1148,... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ezogabine"
]
],
[
[
"Palonosetron",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is... | Palonosetron (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Ezogabine (Compound)
Palonosetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with ... |
DB00804 | DB00808 | 1,507 | 1,605 | [
"DDInter543",
"DDInter916"
] | Dicyclomine | Indapamide | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Minor | 0 | [
[
[
1507,
23,
1605
]
],
[
[
1507,
62,
811
],
[
811,
1,
1605
]
],
[
[
1507,
21,
28900
],
[
28900,
60,
1605
]
],
[
[
1507,
24,
1511
],
[
151... | [
[
[
"Dicyclomine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Indapamide"
]
],
[
[
"Dicyclomine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metolazone"
],
[
... | Dicyclomine may cause a minor interaction that can limit clinical effects when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound)
Dicyclomine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Indapamide (Compound)
Dicyclomine may cause a moderate i... |
DB00945 | DB03619 | 1,479 | 557 | [
"DDInter20",
"DDInter501"
] | Acetylsalicylic acid | Deoxycholic acid | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic... | Moderate | 1 | [
[
[
1479,
24,
557
]
],
[
[
1479,
64,
126
],
[
126,
24,
557
]
],
[
[
1479,
25,
405
],
[
405,
63,
557
]
],
[
[
1479,
63,
702
],
[
702,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deoxycholic acid"
]
],
[
[
"Acetylsalicylic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
],... | Acetylsalicylic acid may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid
Acetylsalicylic acid may lead to a major life threatening interaction when taken with Acalabrutinib and Acalabrutin... |
DB00060 | DB01362 | 912 | 497 | [
"DDInter947",
"DDInter960"
] | Interferon beta-1a | Iohexol | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
912,
25,
497
]
],
[
[
912,
24,
1523
],
[
1523,
24,
497
]
],
[
[
912,
24,
242
],
[
242,
63,
497
]
],
[
[
912,
24,
1416
],
[
1416,
... | [
[
[
"Interferon beta-1a",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
[
... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Iohexol
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir... |
DB00675 | DB09061 | 888 | 1,627 | [
"DDInter1744",
"DDInter284"
] | Tamoxifen | Cannabidiol | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
888,
24,
1627
]
],
[
[
888,
63,
723
],
[
723,
23,
1627
]
],
[
[
888,
24,
760
],
[
760,
62,
1627
]
],
[
[
888,
24,
609
],
[
609,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicista... |
DB01155 | DB06589 | 872 | 1,250 | [
"DDInter813",
"DDInter1400"
] | Gemifloxacin | Pazopanib | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
872,
24,
1250
]
],
[
[
872,
21,
29203
],
[
29203,
60,
1250
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],
[
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872,
62,
112
],
[
112,
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],
[
[
872,
24,
1151
],
[
1151,
... | [
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Gemifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Aspartate aminotransferase increased"
],
[
"Aspartate amin... | Gemifloxacin (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Pazopanib (Compound)
Gemifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interact... |
DB00569 | DB01254 | 553 | 1,213 | [
"DDInter775",
"DDInter484"
] | Fondaparinux | Dasatinib | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
553,
25,
1213
]
],
[
[
553,
21,
28882
],
[
28882,
60,
1213
]
],
[
[
553,
23,
539
],
[
539,
62,
1213
]
],
[
[
553,
24,
738
],
[
738,
... | [
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Fondaparinux",
"{u} (Compound) causes {v} (Side Effect)",
"Body temperature increased"
],
[
"Body temperature increased",
"{u}... | Fondaparinux (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasatinib (Compound)
Fondaparinux may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical ef... |
DB00407 | DB11095 | 202 | 235 | [
"DDInter115",
"DDInter505"
] | Ardeparin | Desirudin | Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
202,
25,
235
]
],
[
[
202,
63,
1595
],
[
1595,
24,
235
]
],
[
[
202,
24,
1151
],
[
1151,
24,
235
]
],
[
[
202,
24,
298
],
[
298,
... | [
[
[
"Ardeparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Ardeparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Collagenase clostridium histolyticum"
],
... | Ardeparin may cause a moderate interaction that could exacerbate diseases when taken with Collagenase clostridium histolyticum and Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Ardeparin may cause a moderate interaction that could exacerba... |
DB01229 | DB01259 | 973 | 392 | [
"DDInter1377",
"DDInter1024"
] | Paclitaxel | Lapatinib | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
973,
24,
392
]
],
[
[
973,
5,
11579
],
[
11579,
44,
392
]
],
[
[
973,
6,
4973
],
[
4973,
45,
392
]
],
[
[
973,
7,
10780
],
[
10780,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Paclitaxel",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is treat... | Paclitaxel (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Lapatinib (Compound)
Paclitaxel (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Paclitaxel (Compound) upregulates CCNB2 (Gene) and CCNB2 (Gene) is upregulated by Lapatinib (Compound)
Paclitaxel... |
DB05676 | DB11652 | 1,513 | 1,155 | [
"DDInter111",
"DDInter1891"
] | Apremilast | Tucatinib | Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Moderate | 1 | [
[
[
1513,
24,
1155
]
],
[
[
1513,
63,
1101
],
[
1101,
23,
1155
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],
[
[
1513,
24,
1320
],
[
1320,
63,
1155
]
],
[
[
1513,
63,
1220
],
[
12... | [
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tucatinib"
]
],
[
[
"Apremilast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix ma... |
DB12498 | DB14711 | 76 | 779 | [
"DDInter1238",
"DDInter1680"
] | Mogamulizumab | Smallpox (Vaccinia) Vaccine, Live | Mogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become canc... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
76,
25,
779
]
],
[
[
76,
64,
1064
],
[
1064,
25,
779
]
],
[
[
76,
63,
270
],
[
270,
25,
779
]
],
[
[
76,
25,
676
],
[
676,
64,
... | [
[
[
"Mogamulizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Mogamulizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
... | Mogamulizumab may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Mogamulizumab may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocreli... |
DB00001 | DB00208 | 1,578 | 1,018 | [
"DDInter1037",
"DDInter1804"
] | Lepirudin | Ticlopidine | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Major | 2 | [
[
[
1578,
25,
1018
]
],
[
[
1578,
25,
1347
],
[
1347,
64,
1018
]
],
[
[
1578,
23,
1631
],
[
1631,
62,
1018
]
],
[
[
1578,
25,
1271
],
[
12... | [
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ticlopidine"
]
],
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clopidogrel"
],
[
"Clopidogrel",
"{u} ... | Lepirudin may lead to a major life threatening interaction when taken with Clopidogrel and Clopidogrel may lead to a major life threatening interaction when taken with Ticlopidine
Lepirudin may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor interaction ... |
DB00238 | DB00604 | 188 | 1,425 | [
"DDInter1285",
"DDInter385"
] | Nevirapine | Cisapride | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Moderate | 1 | [
[
[
188,
24,
1425
]
],
[
[
188,
24,
883
],
[
883,
1,
1425
]
],
[
[
188,
6,
8717
],
[
8717,
45,
1425
]
],
[
[
188,
25,
1362
],
[
1362,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisapride"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Cisapride (Compound)
Nevirapine (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Cisapride (Compound)
Nevirapine may lead to a major life threatening interaction when taken... |
DB00358 | DB09121 | 1,010 | 1,328 | [
"DDInter1140",
"DDInter140"
] | Mefloquine | Aurothioglucose | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Aurothioglucose, also known as gold thioglucose, was formerly used to treat rheumatoid arthritis. Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis . The use of gold compounds has decreased si... | Major | 2 | [
[
[
1010,
25,
1328
]
],
[
[
1010,
24,
1555
],
[
1555,
24,
1328
]
],
[
[
1010,
25,
1593
],
[
1593,
24,
1328
]
],
[
[
1010,
23,
112
],
[
112... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aurothioglucose"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
[
"Oxal... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Aurothioglucose
Mefloquine may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may... |
DB00158 | DB00375 | 356 | 1,037 | [
"DDInter771",
"DDInter433"
] | Folic acid | Colestipol | Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic aci... | Bile acid sequestrants like colestipol have been in use since the 1970s.[FDA Label, F4555, F4567, L6262] And even though such an agent may very well be useful in reducing elevated cholesterol levels and decreasing the risk for atherosclerotic vascular disease due to hypercholesterolemia, colestipol is still generally o... | Moderate | 1 | [
[
[
356,
24,
1037
]
],
[
[
356,
21,
29336
],
[
29336,
60,
1037
]
],
[
[
356,
21,
29336
],
[
29336,
60,
303
],
[
303,
63,
1037
]
],
[
[
356... | [
[
[
"Folic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Colestipol"
]
],
[
[
"Folic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Digestion impaired"
],
[
"Digestion impaired",
"{u} (Si... | Folic acid (Compound) causes Digestion impaired (Side Effect) and Digestion impaired (Side Effect) is caused by Colestipol (Compound)
Folic acid (Compound) causes Digestion impaired (Side Effect) and Digestion impaired (Side Effect) is caused by Medroxyprogesterone acetate (Compound) and Medroxyprogesterone acetate may... |
DB00773 | DB06772 | 896 | 310 | [
"DDInter702",
"DDInter259"
] | Etoposide | Cabazitaxel | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Moderate | 1 | [
[
[
896,
24,
310
]
],
[
[
896,
24,
973
],
[
973,
24,
310
]
],
[
[
896,
5,
11562
],
[
11562,
44,
310
]
],
[
[
896,
6,
7524
],
[
7524,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Etoposide (Compound) treats prostate cancer (Disease) and prostate cancer (Disease) is treated by Cabazitaxel (C... |
DB00939 | DB01067 | 1,338 | 959 | [
"DDInter1135",
"DDInter826"
] | Meclofenamic acid | Glipizide | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
1338,
24,
959
]
],
[
[
1338,
63,
245
],
[
245,
40,
959
]
],
[
[
1338,
24,
1411
],
[
1411,
1,
959
]
],
[
[
1338,
21,
28698
],
[
28698,
... | [
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
... | Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipi... |
DB01033 | DB09061 | 328 | 1,627 | [
"DDInter1156",
"DDInter284"
] | Mercaptopurine | Cannabidiol | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
328,
24,
1627
]
],
[
[
328,
24,
384
],
[
384,
23,
1627
]
],
[
[
328,
63,
597
],
[
597,
23,
1627
]
],
[
[
328,
24,
1613
],
[
1613,
... | [
[
[
"Mercaptopurine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Mercaptopurine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],... | Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenico... |
DB01044 | DB11248 | 246 | 1,193 | [
"DDInter809",
"DDInter1965"
] | Gatifloxacin | Zinc gluconate | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Moderate | 1 | [
[
[
246,
24,
1193
]
],
[
[
246,
63,
1096
],
[
1096,
23,
1193
]
],
[
[
246,
24,
1596
],
[
1596,
23,
1193
]
],
[
[
246,
64,
167
],
[
167,
... | [
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
... | Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with I... |
DB01060 | DB01125 | 319 | 279 | [
"DDInter83",
"DDInter98"
] | Amoxicillin | Anisindione | Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin. Amoxicillin was granted FDA approval on 18 January 1974. | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Moderate | 1 | [
[
[
319,
24,
279
]
],
[
[
319,
63,
1572
],
[
1572,
24,
279
]
],
[
[
319,
24,
1074
],
[
1074,
63,
279
]
],
[
[
319,
23,
609
],
[
609,
... | [
[
[
"Amoxicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"
]
],
[
[
"Amoxicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
],
... | Amoxicillin may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Anisindione
Amoxicillin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-1... |
DB01005 | DB11943 | 995 | 255 | [
"DDInter894",
"DDInter495"
] | Hydroxyurea | Delafloxacin | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Minor | 0 | [
[
[
995,
23,
255
]
],
[
[
995,
63,
1001
],
[
1001,
23,
255
]
],
[
[
995,
24,
60
],
[
60,
23,
255
]
],
[
[
995,
63,
663
],
[
663,
24,... | [
[
[
"Hydroxyurea",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Delafloxacin"
]
],
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mechlorethamine"
],
... | Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Mechlorethamine and Mechlorethamine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Capecitab... |
DB00358 | DB12245 | 1,010 | 823 | [
"DDInter1140",
"DDInter1863"
] | Mefloquine | Triclabendazole | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1010,
24,
823
]
],
[
[
1010,
23,
1247
],
[
1247,
23,
823
]
],
[
[
1010,
24,
1612
],
[
1612,
24,
823
]
],
[
[
1010,
24,
1619
],
[
1619,... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Mefloquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],... | Mefloquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Fostemsa... |
DB04575 | DB14740 | 35 | 771 | [
"DDInter1555",
"DDInter881"
] | Quinestrol | Hyaluronidase | The 3-cyclopentyl ether of ethinyl estradiol. | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
35,
23,
771
]
],
[
[
35,
40,
1438
],
[
1438,
23,
771
]
],
[
[
35,
63,
167
],
[
167,
23,
771
]
],
[
[
35,
40,
1438
],
[
1438,
63,... | [
[
[
"Quinestrol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Quinestrol",
"{u} (Compound) resembles {v} (Compound)",
"Estradiol"
],
[
"Estradiol",
"{u} may cause a minor in... | Quinestrol (Compound) resembles Estradiol (Compound) and Estradiol may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Quinestrol may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that c... |
DB00218 | DB06723 | 1,176 | 115 | [
"DDInter1247",
"DDInter58"
] | Moxifloxacin | Aluminum hydroxide | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
1176,
24,
115
]
],
[
[
1176,
21,
28775
],
[
28775,
60,
115
]
],
[
[
1176,
25,
870
],
[
870,
23,
115
]
],
[
[
1176,
24,
355
],
[
355,
... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Phlebitis"
],
[
"Phlebitis",
"{u} (Side Eff... | Moxifloxacin (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Aluminum hydroxide (Compound)
Moxifloxacin may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Al... |
DB00647 | DB11057 | 675 | 720 | [
"DDInter528",
"DDInter1223"
] | Dextropropoxyphene | Mineral oil | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
675,
24,
720
]
],
[
[
675,
24,
927
],
[
927,
63,
720
]
],
[
[
675,
24,
1151
],
[
1151,
24,
720
]
],
[
[
675,
25,
1069
],
[
1069,
... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafeni... | Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Su... |
DB01097 | DB14783 | 1,377 | 287 | [
"DDInter1033",
"DDInter574"
] | Leflunomide | Diroximel fumarate | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Major | 2 | [
[
[
1377,
25,
287
]
],
[
[
1377,
64,
1101
],
[
1101,
24,
287
]
],
[
[
1377,
25,
812
],
[
812,
24,
287
]
],
[
[
1377,
24,
1430
],
[
1430,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",
... | Leflunomide may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Leflunomide may lead to a major life threatening interaction when taken with Siltuximab and Siltuximab may cause a mod... |
DB00307 | DB11703 | 1,101 | 405 | [
"DDInter202",
"DDInter9"
] | Bexarotene | Acalabrutinib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
1101,
24,
405
]
],
[
[
1101,
23,
1051
],
[
1051,
24,
405
]
],
[
[
1101,
62,
1324
],
[
1324,
24,
405
]
],
[
[
1101,
25,
139
],
[
139,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aminoglutethimide"
],
... | Bexarotene may cause a minor interaction that can limit clinical effects when taken with Aminoglutethimide and Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Troglita... |
DB00209 | DB00316 | 352 | 474 | [
"DDInter1886",
"DDInter14"
] | Trospium | Acetaminophen | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the ... | Minor | 0 | [
[
[
352,
23,
474
]
],
[
[
352,
6,
12523
],
[
12523,
45,
474
]
],
[
[
352,
21,
28792
],
[
28792,
60,
474
]
],
[
[
352,
24,
1511
],
[
1511,
... | [
[
[
"Trospium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetaminophen"
]
],
[
[
"Trospium",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Trospium (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Acetaminophen (Compound)
Trospium (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Acetaminophen (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases whe... |
DB00208 | DB01166 | 1,018 | 477 | [
"DDInter1804",
"DDInter379"
] | Ticlopidine | Cilostazol | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Major | 2 | [
[
[
1018,
25,
477
]
],
[
[
1018,
6,
8374
],
[
8374,
45,
477
]
],
[
[
1018,
21,
29340
],
[
29340,
60,
477
]
],
[
[
1018,
23,
801
],
[
801,
... | [
[
[
"Ticlopidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
]
],
[
[
"Ticlopidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cilos... | Ticlopidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Ticlopidine (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Cilostazol (Compound)
Ticlopidine may cause a minor interaction that can limit clinical effects when... |
DB00682 | DB00783 | 126 | 1,438 | [
"DDInter1951",
"DDInter679"
] | Warfarin | Estradiol | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Moderate | 1 | [
[
[
126,
24,
1438
]
],
[
[
126,
64,
1561
],
[
1561,
40,
1438
]
],
[
[
126,
24,
35
],
[
35,
40,
1438
]
],
[
[
126,
63,
559
],
[
559,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Testosterone"
],
[
"Testosterone"... | Warfarin may lead to a major life threatening interaction when taken with Testosterone and Testosterone (Compound) resembles Estradiol (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol and Quinestrol (Compound) resembles Estradiol (Compound)
Warfarin may caus... |
DB00414 | DB00668 | 590 | 874 | [
"DDInter16",
"DDInter652"
] | Acetohexamide | Epinephrine | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
590,
24,
874
]
],
[
[
590,
63,
1636
],
[
1636,
1,
874
]
],
[
[
590,
24,
688
],
[
688,
63,
874
]
],
[
[
590,
23,
1551
],
[
1551,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
]... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine (Compound) resembles Epinephrine (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interacti... |
DB00440 | DB11967 | 1,548 | 710 | [
"DDInter1874",
"DDInter210"
] | Trimethoprim | Binimetinib | Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in comb... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
1548,
24,
710
]
],
[
[
1548,
24,
129
],
[
129,
24,
710
]
],
[
[
1548,
25,
663
],
[
663,
24,
710
]
],
[
[
1548,
24,
129
],
[
129,
... | [
[
[
"Trimethoprim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Trimethoprim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Trimethoprim may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Trimethoprim may lead to a major life threatening interaction when taken with Methotrexate and Methotrexa... |
DB00358 | DB14509 | 1,010 | 1,399 | [
"DDInter1140",
"DDInter1081"
] | Mefloquine | Lithium carbonate | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
1010,
24,
1399
]
],
[
[
1010,
23,
1620
],
[
1620,
23,
1399
]
],
[
[
1010,
24,
1374
],
[
1374,
24,
1399
]
],
[
[
1010,
63,
618
],
[
618... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Mefloquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tetracycline"
],
... | Mefloquine may cause a minor interaction that can limit clinical effects when taken with Tetracycline and Tetracycline may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone an... |
DB00005 | DB05239 | 1,057 | 866 | [
"DDInter687",
"DDInter425"
] | Etanercept | Cobimetinib | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Major | 2 | [
[
[
1057,
25,
866
]
],
[
[
1057,
25,
482
],
[
482,
24,
866
]
],
[
[
1057,
24,
33
],
[
33,
24,
866
]
],
[
[
1057,
24,
496
],
[
496,
6... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobimetinib"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tioguanine"
],
[
"Tioguanine",
"{u} ... | Etanercept may lead to a major life threatening interaction when taken with Tioguanine and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone may cause... |
DB00023 | DB00069 | 305 | 367 | [
"DDInter127",
"DDInter946"
] | Asparaginase Escherichia coli | Interferon alfacon-1 | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Moderate | 1 | [
[
[
305,
24,
367
]
],
[
[
305,
24,
467
],
[
467,
63,
367
]
],
[
[
305,
63,
1257
],
[
1257,
24,
367
]
],
[
[
305,
25,
581
],
[
581,
2... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon alfacon-1"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when tak... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1
Asparaginase Escherichia coli may cause a moderate interaction that could exacerb... |
DB00775 | DB05773 | 1,226 | 1,047 | [
"DDInter1818",
"DDInter1848"
] | Tirofiban | Trastuzumab emtansine | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Major | 2 | [
[
[
1226,
25,
1047
]
],
[
[
1226,
24,
848
],
[
848,
24,
1047
]
],
[
[
1226,
63,
886
],
[
886,
24,
1047
]
],
[
[
1226,
24,
643
],
[
643,
... | [
[
[
"Tirofiban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Tirofiban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
"Ib... | Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and ... |
DB00444 | DB14975 | 63 | 988 | [
"DDInter1765",
"DDInter1949"
] | Teniposide | Voxelotor | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Moderate | 1 | [
[
[
63,
24,
988
]
],
[
[
63,
24,
309
],
[
309,
24,
988
]
],
[
[
63,
35,
896
],
[
896,
24,
988
]
],
[
[
63,
25,
676
],
[
676,
63,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voxelotor"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
[
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Voxelotor
Teniposide (Compound) resembles Etoposide (Compound) and Teniposide may cause a moderate interaction that could... |
DB00502 | DB09076 | 1,300 | 1,116 | [
"DDInter853",
"DDInter1899"
] | Haloperidol | Umeclidinium | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
1300,
24,
1116
]
],
[
[
1300,
24,
849
],
[
849,
24,
1116
]
],
[
[
1300,
25,
401
],
[
401,
24,
1116
]
],
[
[
1300,
63,
128
],
[
128,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Haloperidol may lead to a major life threatening interaction when taken with Promethazine and Promethazine ma... |
DB00888 | DB05679 | 1,001 | 1,683 | [
"DDInter1133",
"DDInter1907"
] | Mechlorethamine | Ustekinumab | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
1001,
24,
1683
]
],
[
[
1001,
63,
1461
],
[
1461,
23,
1683
]
],
[
[
1001,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
1001,
24,
1307
],
[
13... | [
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
]... | Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab
Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and O... |
DB01132 | DB06077 | 1,130 | 879 | [
"DDInter1472",
"DDInter1102"
] | Pioglitazone | Lumateperone | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Major | 2 | [
[
[
1130,
25,
879
]
],
[
[
1130,
24,
214
],
[
214,
63,
879
]
],
[
[
1130,
24,
392
],
[
392,
24,
879
]
],
[
[
1130,
63,
999
],
[
999,
... | [
[
[
"Pioglitazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumateperone"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[
"Fo... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib a... |
DB00039 | DB00488 | 1,253 | 196 | [
"DDInter1380",
"DDInter57"
] | Palifermin | Altretamine | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Moderate | 1 | [
[
[
1253,
24,
196
]
],
[
[
1253,
24,
4
],
[
4,
63,
196
]
],
[
[
1253,
24,
599
],
[
599,
24,
196
]
],
[
[
1253,
24,
1064
],
[
1064,
2... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Altretamine"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Altretamine
Palifermin may cause a moderate interaction that could exacerbate diseases when t... |
DB01124 | DB11071 | 1,411 | 1,004 | [
"DDInter1828",
"DDInter1449"
] | Tolbutamide | Phenyl salicylate | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
1411,
24,
1004
]
],
[
[
1411,
62,
660
],
[
660,
23,
1004
]
],
[
[
1411,
63,
1573
],
[
1573,
24,
1004
]
],
[
[
1411,
24,
1074
],
[
1074... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Tolbutamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Esomeprazole"
],... | Tolbutamide may cause a minor interaction that can limit clinical effects when taken with Esomeprazole and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Phenyl salicylate
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Prednisone a... |
DB00938 | DB00999 | 455 | 504 | [
"DDInter1635",
"DDInter883"
] | Salmeterol | Hydrochlorothiazide | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Moderate | 1 | [
[
[
455,
24,
504
]
],
[
[
455,
24,
1326
],
[
1326,
40,
504
]
],
[
[
455,
24,
178
],
[
178,
1,
504
]
],
[
[
455,
63,
323
],
[
323,
40... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenamide"
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Diclofenamide and Diclofenamide (Compound) resembles Hydrochlorothiazide (Compound)
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles Hyd... |
DB00687 | DB01162 | 870 | 195 | [
"DDInter747",
"DDInter1767"
] | Fludrocortisone | Terazosin | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertension[FDA Label]. Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate. | Moderate | 1 | [
[
[
870,
24,
195
]
],
[
[
870,
63,
1205
],
[
1205,
40,
195
]
],
[
[
870,
21,
28714
],
[
28714,
60,
195
]
],
[
[
870,
1,
1220
],
[
1220,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terazosin"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prazosin"
],
... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Prazosin and Prazosin (Compound) resembles Terazosin (Compound)
Fludrocortisone (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Terazosin (Compound)
Fludrocortisone (Compound) resembles Dexam... |
DB00446 | DB12674 | 597 | 975 | [
"DDInter351",
"DDInter1105"
] | Chloramphenicol | Lurbinectedin | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Major | 2 | [
[
[
597,
25,
975
]
],
[
[
597,
24,
1488
],
[
1488,
24,
975
]
],
[
[
597,
24,
159
],
[
159,
63,
975
]
],
[
[
597,
63,
482
],
[
482,
2... | [
[
[
"Chloramphenicol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
[
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Larotr... |
DB00059 | DB10583 | 1,560 | 949 | [
"DDInter1404",
"DDInter415"
] | Pegaspargase | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
1560,
24,
949
]
],
[
[
1560,
24,
250
],
[
250,
24,
949
]
],
[
[
1560,
25,
1377
],
[
1377,
24,
949
]
],
[
[
1560,
25,
1259
],
[
1259,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases wh... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Blinatumomab and Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Pegaspargase may lead to a major life threatening intera... |
DB01044 | DB11110 | 246 | 603 | [
"DDInter809",
"DDInter1115"
] | Gatifloxacin | Magnesium citrate | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
246,
24,
603
]
],
[
[
246,
25,
57
],
[
57,
24,
603
]
],
[
[
246,
40,
739
],
[
739,
24,
603
]
],
[
[
246,
64,
870
],
[
870,
24,
... | [
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Gatifloxacin may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Gatifloxacin (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin may cause a moderate interactio... |
DB00407 | DB00975 | 202 | 1,317 | [
"DDInter115",
"DDInter573"
] | Ardeparin | Dipyridamole | Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with... | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Major | 2 | [
[
[
202,
25,
1317
]
],
[
[
202,
21,
28778
],
[
28778,
60,
1317
]
],
[
[
202,
24,
1496
],
[
1496,
63,
1317
]
],
[
[
202,
25,
714
],
[
714,
... | [
[
[
"Ardeparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dipyridamole"
]
],
[
[
"Ardeparin",
"{u} (Compound) causes {v} (Side Effect)",
"Anaphylactic shock"
],
[
"Anaphylactic shock",
"{u} (Side Effect) is c... | Ardeparin (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Dipyridamole (Compound)
Ardeparin may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib and Nintedanib may cause a moderate interaction that could exacerbate diseases when ... |
DB00782 | DB01224 | 1,123 | 623 | [
"DDInter1535",
"DDInter1553"
] | Propantheline | Quetiapine | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
1123,
24,
623
]
],
[
[
1123,
63,
695
],
[
695,
1,
623
]
],
[
[
1123,
24,
1178
],
[
1178,
1,
623
]
],
[
[
1123,
6,
7992
],
[
7992,
... | [
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
... | Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Quetiapine (Compound)
Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Quetiapi... |
DB00726 | DB01181 | 1,164 | 1,532 | [
"DDInter1876",
"DDInter906"
] | Trimipramine | Ifosfamide | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
1164,
24,
1532
]
],
[
[
1164,
6,
6017
],
[
6017,
45,
1532
]
],
[
[
1164,
21,
28956
],
[
28956,
60,
1532
]
],
[
[
1164,
63,
1648
],
[
1... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Trimipramine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compoun... | Trimipramine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ifosfamide (Compound)
Trimipramine (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Aldesle... |
DB00748 | DB00761 | 662 | 1,621 | [
"DDInter297",
"DDInter1497"
] | Carbinoxamine | Potassium chloride | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Major | 2 | [
[
[
662,
25,
1621
]
],
[
[
662,
21,
28809
],
[
28809,
60,
1621
]
],
[
[
662,
63,
1105
],
[
1105,
25,
1621
]
],
[
[
662,
24,
667
],
[
667,
... | [
[
[
"Carbinoxamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
]
],
[
[
"Carbinoxamine",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) is cause... | Carbinoxamine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Potassium chloride (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Trihexyphenidyl and Trihexyphenidyl may lead to a major life threatening interaction when taken wit... |
DB00486 | DB11732 | 1,614 | 1,097 | [
"DDInter1253",
"DDInter1027"
] | Nabilone | Lasmiditan | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
1614,
24,
1097
]
],
[
[
1614,
63,
701
],
[
701,
24,
1097
]
],
[
[
1614,
24,
662
],
[
662,
24,
1097
]
],
[
[
1614,
40,
530
],
[
530,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbino... |
DB09074 | DB14811 | 1,362 | 385 | [
"DDInter1327",
"DDInter979"
] | Olaparib | Isatuximab | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Moderate | 1 | [
[
[
1362,
24,
385
]
],
[
[
1362,
63,
377
],
[
377,
24,
385
]
],
[
[
1362,
24,
738
],
[
738,
24,
385
]
],
[
[
1362,
64,
384
],
[
384,
... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isatuximab"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mitomycin"
],
[
"... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may... |
DB00708 | DB06372 | 1,454 | 259 | [
"DDInter1718",
"DDInter1594"
] | Sufentanil | Rilonacept | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
1454,
24,
259
]
],
[
[
1454,
24,
1619
],
[
1619,
63,
259
]
],
[
[
1454,
24,
1213
],
[
1213,
24,
259
]
],
[
[
1454,
1,
704
],
[
704,
... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[
... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib... |
DB09054 | DB14783 | 384 | 287 | [
"DDInter905",
"DDInter574"
] | Idelalisib | Diroximel fumarate | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
384,
24,
287
]
],
[
[
384,
63,
1101
],
[
1101,
24,
287
]
],
[
[
384,
24,
1583
],
[
1583,
24,
287
]
],
[
[
384,
25,
951
],
[
951,
... | [
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab and... |
DB06168 | DB08868 | 1,531 | 1,011 | [
"DDInter281",
"DDInter737"
] | Canakinumab | Fingolimod | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1531,
25,
1011
]
],
[
[
1531,
24,
748
],
[
748,
63,
1011
]
],
[
[
1531,
24,
1136
],
[
1136,
24,
1011
]
],
[
[
1531,
63,
1081
],
[
1081... | [
[
[
"Canakinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Canakinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
[
"Ant... | Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Denosumab... |
DB00598 | DB08907 | 1,523 | 1,344 | [
"DDInter1013",
"DDInter280"
] | Labetalol | Canagliflozin | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1523,
24,
1344
]
],
[
[
1523,
24,
549
],
[
549,
1,
1344
]
],
[
[
1523,
21,
28681
],
[
28681,
60,
1344
]
],
[
[
1523,
24,
1486
],
[
148... | [
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Labetalol (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Canagliflozin (Compound)
Labetalol may cause ... |
DB00295 | DB00883 | 475 | 426 | [
"DDInter1244",
"DDInter989"
] | Morphine | Isosorbide dinitrate | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action. | Moderate | 1 | [
[
[
475,
24,
426
]
],
[
[
475,
24,
1107
],
[
1107,
1,
426
]
],
[
[
475,
6,
8374
],
[
8374,
45,
426
]
],
[
[
475,
10,
11576
],
[
11576,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isosorbide dinitrate"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isosorbide mononitrat... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide mononitrate and Isosorbide mononitrate (Compound) resembles Isosorbide dinitrate (Compound)
Morphine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Isosorbide dinitrate (Compound)
Morphine (Compound) pallia... |
DB00459 | DB00704 | 640 | 267 | [
"DDInter21",
"DDInter1263"
] | Acitretin | Naltrexone | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
640,
24,
267
]
],
[
[
640,
21,
29457
],
[
29457,
60,
267
]
],
[
[
640,
24,
850
],
[
850,
63,
267
]
],
[
[
640,
64,
1101
],
[
1101,
... | [
[
[
"Acitretin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Acitretin",
"{u} (Compound) causes {v} (Side Effect)",
"Disturbance in sexual arousal"
],
[
"Disturbance in sexual arou... | Acitretin (Compound) causes Disturbance in sexual arousal (Side Effect) and Disturbance in sexual arousal (Side Effect) is caused by Naltrexone (Compound)
Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interactio... |
DB08822 | DB09038 | 911 | 1,450 | [
"DDInter156",
"DDInter636"
] | Azilsartan medoxomil | Empagliflozin | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
911,
24,
1450
]
],
[
[
911,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
911,
40,
217
],
[
217,
24,
1450
]
],
[
[
911,
24,
1455
],
[
1455,
... | [
[
[
"Azilsartan medoxomil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Azilsartan medoxomil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trep... | Azilsartan medoxomil may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Azilsartan medoxomil (Compound) resembles Olmesartan (Compound) and Olmesartan may cause a mode... |
DB00491 | DB09129 | 127 | 625 | [
"DDInter1217",
"DDInter373"
] | Miglitol | Chromic chloride | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Chromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN). | Moderate | 1 | [
[
[
127,
24,
625
]
],
[
[
127,
24,
1021
],
[
1021,
24,
625
]
],
[
[
127,
24,
1296
],
[
1296,
63,
625
]
],
[
[
127,
63,
590
],
[
590,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chromic chloride"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
],
[... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide and Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Chromic chloride
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec ... |
DB01100 | DB01169 | 1,568 | 57 | [
"DDInter1470",
"DDInter120"
] | Pimozide | Arsenic trioxide | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
1568,
25,
57
]
],
[
[
1568,
6,
8374
],
[
8374,
45,
57
]
],
[
[
1568,
62,
112
],
[
112,
23,
57
]
],
[
[
1568,
24,
603
],
[
603,
6... | [
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Pimozide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Arsen... | Pimozide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Pimozide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
Pimozide... |
DB06081 | DB11312 | 1,046 | 298 | [
"DDInter286",
"DDInter1542"
] | Caplacizumab | Protein C | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade. Protein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. It is converted by the thrombin/thrombomodulin-complex on the e... | Major | 2 | [
[
[
1046,
25,
298
]
],
[
[
1046,
25,
707
],
[
707,
24,
298
]
],
[
[
1046,
24,
321
],
[
321,
63,
298
]
],
[
[
1046,
64,
500
],
[
500,
... | [
[
[
"Caplacizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Protein C"
]
],
[
[
"Caplacizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
],
[
"Danaparoid",
"{u... | Caplacizumab may lead to a major life threatening interaction when taken with Danaparoid and Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Protein C
Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib and Selumetinib may c... |
DB00957 | DB11718 | 873 | 927 | [
"DDInter1314",
"DDInter640"
] | Norgestimate | Encorafenib | Norgestimate was first described in the literature in 1977. It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. It is commonly formulated with [ethinylestradiol] as a combined oral contraceptive that can also be used to treat mod... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
873,
25,
927
]
],
[
[
873,
24,
484
],
[
484,
63,
927
]
],
[
[
873,
24,
1094
],
[
1094,
24,
927
]
],
[
[
873,
64,
1101
],
[
1101,
... | [
[
[
"Norgestimate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Norgestimate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
],
[
"Entr... | Norgestimate may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Norgestimate may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin an... |
DB04865 | DB10315 | 4 | 1,137 | [
"DDInter1335",
"DDInter1127"
] | Omacetaxine mepesuccinate | Measles virus vaccine live attenuated | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
4,
25,
1137
]
],
[
[
4,
63,
1042
],
[
1042,
24,
1137
]
],
[
[
4,
24,
119
],
[
119,
64,
1137
]
],
[
[
4,
64,
273
],
[
273,
25,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wit... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide and Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Measles virus vaccine live attenuated
Omacetaxine mepesuccinate may cause a moderate interaction tha... |
DB05528 | DB09122 | 1,070 | 1,613 | [
"DDInter1228",
"DDInter1409"
] | Mipomersen | Peginterferon beta-1a | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Major | 2 | [
[
[
1070,
25,
1613
]
],
[
[
1070,
64,
600
],
[
600,
24,
1613
]
],
[
[
1070,
25,
263
],
[
263,
24,
1613
]
],
[
[
1070,
25,
351
],
[
351,
... | [
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
"Fluconazole",... | Mipomersen may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Mipomersen may lead to a major life threatening interaction when taken with Axitinib and Axitinib may cause a mode... |
DB00957 | DB06168 | 873 | 1,531 | [
"DDInter1314",
"DDInter281"
] | Norgestimate | Canakinumab | Norgestimate was first described in the literature in 1977. It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. It is commonly formulated with [ethinylestradiol] as a combined oral contraceptive that can also be used to treat mod... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
873,
24,
1531
]
],
[
[
873,
24,
1362
],
[
1362,
63,
1531
]
],
[
[
873,
25,
1476
],
[
1476,
63,
1531
]
],
[
[
873,
40,
1197
],
[
1197,
... | [
[
[
"Norgestimate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Norgestimate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[... | Norgestimate may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Norgestimate may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause... |
DB01041 | DB11817 | 770 | 1,259 | [
"DDInter1789",
"DDInter165"
] | Thalidomide | Baricitinib | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
770,
25,
1259
]
],
[
[
770,
63,
421
],
[
421,
24,
1259
]
],
[
[
770,
24,
949
],
[
949,
24,
1259
]
],
[
[
770,
24,
1129
],
[
1129,
... | [
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydromorphone"
],
[
"Hydr... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Clostridium ... |
DB00694 | DB00888 | 51 | 1,001 | [
"DDInter485",
"DDInter1133"
] | Daunorubicin | Mechlorethamine | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Moderate | 1 | [
[
[
51,
24,
1001
]
],
[
[
51,
63,
450
],
[
450,
1,
1001
]
],
[
[
51,
5,
11555
],
[
11555,
44,
1001
]
],
[
[
51,
21,
28725
],
[
28725,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mechlorethamine"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclophosphamide"
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Cyclophosphamide and Cyclophosphamide (Compound) resembles Mechlorethamine (Compound)
Daunorubicin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Mechlorethamine (Compound)
Daunoru... |
DB08881 | DB12161 | 868 | 730 | [
"DDInter1925",
"DDInter512"
] | Vemurafenib | Deutetrabenazine | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Major | 2 | [
[
[
868,
25,
730
]
],
[
[
868,
62,
112
],
[
112,
23,
730
]
],
[
[
868,
64,
322
],
[
322,
24,
730
]
],
[
[
868,
63,
1559
],
[
1559,
2... | [
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Vemurafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"M... | Vemurafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Deutetrabenazine
Vemurafenib may lead to a major life threatening interaction when taken with Epirubicin and Epirubicin ... |
DB08911 | DB09054 | 1,556 | 384 | [
"DDInter1842",
"DDInter905"
] | Trametinib | Idelalisib | Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 inhibitor.[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. It was later approved by Health Canada on July 18, 2013 and by the European Commission on June 30, 2014. ... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1556,
24,
384
]
],
[
[
1556,
24,
241
],
[
241,
63,
384
]
],
[
[
1556,
24,
1040
],
[
1040,
24,
384
]
],
[
[
1556,
63,
129
],
[
129,
... | [
[
[
"Trametinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Trametinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erdafitinib"
],
[
... | Trametinib may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib and Erdafitinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Trametinib may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabr... |
DB00013 | DB01009 | 1,255 | 935 | [
"DDInter1905",
"DDInter1009"
] | Urokinase | Ketoprofen | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
1255,
24,
935
]
],
[
[
1255,
24,
1274
],
[
1274,
24,
935
]
],
[
[
1255,
24,
886
],
[
886,
1,
935
]
],
[
[
1255,
25,
1046
],
[
1046,
... | [
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[
... | Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketor... |
DB00455 | DB01764 | 1,601 | 805 | [
"DDInter1091",
"DDInter469"
] | Loratadine | Dalfopristin | Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations. | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Moderate | 1 | [
[
[
1601,
24,
805
]
],
[
[
1601,
6,
8374
],
[
8374,
45,
805
]
],
[
[
1601,
24,
283
],
[
283,
62,
805
]
],
[
[
1601,
24,
384
],
[
384,
... | [
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalfopristin"
]
],
[
[
"Loratadine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Loratadine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dalfopristin (Compound)
Loratadine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Dalfopristin
Loratadine may c... |
DB00757 | DB00843 | 1,166 | 479 | [
"DDInter581",
"DDInter583"
] | Dolasetron | Donepezil | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
1166,
24,
479
]
],
[
[
1166,
25,
843
],
[
843,
1,
479
]
],
[
[
1166,
6,
12523
],
[
12523,
45,
479
]
],
[
[
1166,
21,
28940
],
[
28940,... | [
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tetrabenazine"
],
[
"Tetraben... | Dolasetron may lead to a major life threatening interaction when taken with Tetrabenazine and Tetrabenazine (Compound) resembles Donepezil (Compound)
Dolasetron (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound)
Dolasetron (Compound) causes Blood alkaline phosphatase increased (Side Effec... |
DB00055 | DB06228 | 834 | 792 | [
"DDInter605",
"DDInter1609"
] | Drotrecogin alfa | Rivaroxaban | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
834,
25,
792
]
],
[
[
834,
23,
944
],
[
944,
62,
792
]
],
[
[
834,
24,
901
],
[
901,
24,
792
]
],
[
[
834,
24,
643
],
[
643,
63,... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Drotrecogin alfa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"... | Drotrecogin alfa may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Rivaroxaban
Drotrecogin alfa may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran an... |
DB00581 | DB00818 | 355 | 898 | [
"DDInter1018",
"DDInter1538"
] | Lactulose | Propofol | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associate... | Moderate | 1 | [
[
[
355,
24,
898
]
],
[
[
355,
21,
28785
],
[
28785,
60,
898
]
],
[
[
355,
24,
392
],
[
392,
63,
898
]
],
[
[
355,
24,
1557
],
[
1557,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propofol"
]
],
[
[
"Lactulose",
"{u} (Compound) causes {v} (Side Effect)",
"Muscle spasms"
],
[
"Muscle spasms",
"{u} (Side Effect) is ... | Lactulose (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Propofol (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Propo... |
DB00055 | DB01175 | 834 | 318 | [
"DDInter605",
"DDInter672"
] | Drotrecogin alfa | Escitalopram | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Moderate | 1 | [
[
[
834,
24,
318
]
],
[
[
834,
24,
1230
],
[
1230,
1,
318
]
],
[
[
834,
25,
714
],
[
714,
24,
318
]
],
[
[
834,
64,
1432
],
[
1432,
... | [
[
[
"Drotrecogin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
]
],
[
[
"Drotrecogin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
... | Drotrecogin alfa may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Drotrecogin alfa may lead to a major life threatening interaction when taken with Iloprost and Iloprost may cause a moderate interaction that could exac... |
DB00424 | DB00960 | 19 | 887 | [
"DDInter896",
"DDInter1471"
] | Hyoscyamine | Pindolol | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Moderate | 1 | [
[
[
19,
24,
887
]
],
[
[
19,
24,
819
],
[
819,
40,
887
]
],
[
[
19,
63,
88
],
[
88,
40,
887
]
],
[
[
19,
24,
1121
],
[
1121,
1,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
[
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Pindolol (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Pindolol (Compound)
Hy... |
DB08880 | DB08899 | 1,510 | 129 | [
"DDInter1771",
"DDInter649"
] | Teriflunomide | Enzalutamide | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1510,
24,
129
]
],
[
[
1510,
64,
918
],
[
918,
1,
129
]
],
[
[
1510,
25,
110
],
[
110,
62,
129
]
],
[
[
1510,
63,
112
],
[
112,
... | [
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
],
[
"... | Teriflunomide may lead to a major life threatening interaction when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Teriflunomide may lead to a major life threatening interaction when taken with Polatuzumab vedotin and Polatuzumab vedotin may cause a minor interaction that can limi... |
DB00041 | DB00968 | 1,648 | 1,551 | [
"DDInter38",
"DDInter1185"
] | Aldesleukin | Methyldopa | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrener... | Moderate | 1 | [
[
[
1648,
24,
1551
]
],
[
[
1648,
24,
1264
],
[
1264,
62,
1551
]
],
[
[
1648,
24,
1486
],
[
1486,
24,
1551
]
],
[
[
1648,
25,
976
],
[
976... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyldopa"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a minor interaction that can limit clinical effects when taken with Methyldopa
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Meth... |
DB00341 | DB00842 | 1,242 | 686 | [
"DDInter343",
"DDInter1359"
] | Cetirizine | Oxazepam | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feat... | Moderate | 1 | [
[
[
1242,
24,
686
]
],
[
[
1242,
24,
695
],
[
695,
40,
686
]
],
[
[
1242,
24,
1119
],
[
1119,
1,
686
]
],
[
[
1242,
63,
905
],
[
905,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxazepam"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Oxazepam (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) resembles Oxazepam (Comp... |
DB00041 | DB00552 | 1,648 | 1,238 | [
"DDInter38",
"DDInter1425"
] | Aldesleukin | Pentostatin | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Moderate | 1 | [
[
[
1648,
24,
1238
]
],
[
[
1648,
23,
1467
],
[
1467,
23,
1238
]
],
[
[
1648,
23,
1539
],
[
1539,
62,
1238
]
],
[
[
1648,
24,
995
],
[
995... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentostatin"
]
],
[
[
"Aldesleukin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enoxacin"
],
[
... | Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin may cause a minor interaction that can limit clinical effects when taken with Pentostatin
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Ofloxacin and Ofloxacin may ... |
DB00222 | DB00627 | 245 | 265 | [
"DDInter825",
"DDInter1286"
] | Glimepiride | Niacin | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Moderate | 1 | [
[
[
245,
24,
265
]
],
[
[
245,
21,
29519
],
[
29519,
60,
265
]
],
[
[
245,
24,
1479
],
[
1479,
62,
265
]
],
[
[
245,
24,
1296
],
[
1296,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niacin"
]
],
[
[
"Glimepiride",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal symptom NOS"
],
[
"Gastrointestinal symptom NO... | Glimepiride (Compound) causes Gastrointestinal symptom NOS (Side Effect) and Gastrointestinal symptom NOS (Side Effect) is caused by Niacin (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction t... |
DB00230 | DB00372 | 784 | 999 | [
"DDInter1516",
"DDInter1793"
] | Pregabalin | Thiethylperazine | Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively characterized, there is evide... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Moderate | 1 | [
[
[
784,
24,
999
]
],
[
[
784,
24,
1614
],
[
1614,
63,
999
]
],
[
[
784,
24,
1242
],
[
1242,
24,
999
]
],
[
[
784,
25,
475
],
[
475,
... | [
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
... | Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Ceti... |
DB00618 | DB01390 | 1,572 | 1,117 | [
"DDInter498",
"DDInter1683"
] | Demeclocycline | Sodium bicarbonate | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Moderate | 1 | [
[
[
1572,
24,
1117
]
],
[
[
1572,
63,
663
],
[
663,
23,
1117
]
],
[
[
1572,
24,
954
],
[
954,
23,
1117
]
],
[
[
1572,
24,
1482
],
[
1482,
... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexat... | Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbonate
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Qui... |
DB00594 | DB06754 | 863 | 707 | [
"DDInter68",
"DDInter471"
] | Amiloride | Danaparoid | A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Moderate | 1 | [
[
[
863,
24,
707
]
],
[
[
863,
24,
222
],
[
222,
24,
707
]
],
[
[
863,
24,
365
],
[
365,
64,
707
]
],
[
[
863,
24,
848
],
[
848,
25,... | [
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danaparoid"
]
],
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin and Daltep... |
DB01234 | DB09143 | 1,220 | 313 | [
"DDInter513",
"DDInter1701"
] | Dexamethasone | Sonidegib | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Major | 2 | [
[
[
1220,
25,
313
]
],
[
[
1220,
25,
478
],
[
478,
24,
313
]
],
[
[
1220,
24,
1478
],
[
1478,
24,
313
]
],
[
[
1220,
25,
1375
],
[
1375,
... | [
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sonidegib"
]
],
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
],
[
"Nilotinib",
"{u... | Dexamethasone may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Sonidegib
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause... |
DB00322 | DB00526 | 141 | 1,555 | [
"DDInter742",
"DDInter1355"
] | Floxuridine | Oxaliplatin | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
141,
24,
1555
]
],
[
[
141,
24,
810
],
[
810,
63,
1555
]
],
[
[
141,
1,
231
],
[
231,
63,
1555
]
],
[
[
141,
63,
1257
],
[
1257,
... | [
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89... | Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89 and Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Floxuridine (Compound) resembles Stavudine (Compound) and Stavudine may cause a mo... |
DB00095 | DB11569 | 66 | 1,093 | [
"DDInter623",
"DDInter1003"
] | Efalizumab | Ixekizumab | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Moderate | 1 | [
[
[
66,
24,
1093
]
],
[
[
66,
23,
1114
],
[
1114,
23,
1093
]
],
[
[
66,
24,
496
],
[
496,
24,
1093
]
],
[
[
66,
63,
599
],
[
599,
24... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
]
],
[
[
"Efalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
... | Efalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Ixekizumab
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine a... |
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