drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB05578 | DB09030 | 330 | 840 | [
"DDInter1566",
"DDInter1945"
] | Ramucirumab | Vorapaxar | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
330,
25,
840
]
],
[
[
330,
63,
765
],
[
765,
24,
840
]
],
[
[
330,
64,
885
],
[
885,
24,
840
]
],
[
[
330,
25,
578
],
[
578,
24,... | [
[
[
"Ramucirumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Ramucirumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hemin"
],
[
"Hemin",
... | Ramucirumab may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Ramucirumab may lead to a major life threatening interaction when taken with Epoprostenol and Epoprostenol may cause a mod... |
DB01364 | DB11124 | 22 | 209 | [
"DDInter650",
"DDInter1560"
] | Ephedrine | Racepinephrine | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Racepinephrine is a racemic mixture consisting of d- and l- enantiomers. Epinephrine is a non-selective α- and β-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including wheezing, tightness of chest and shortness of breath. It is an active ingred... | Moderate | 1 | [
[
[
22,
24,
209
]
],
[
[
22,
62,
1220
],
[
1220,
23,
209
]
],
[
[
22,
63,
688
],
[
688,
24,
209
]
],
[
[
22,
64,
222
],
[
222,
24,
... | [
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Racepinephrine"
]
],
[
[
"Ephedrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexamethasone"
],
[... | Ephedrine may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Racepinephrine
Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Sa... |
DB00581 | DB09020 | 355 | 28 | [
"DDInter1018",
"DDInter212"
] | Lactulose | Bisacodyl | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
355,
24,
28
]
],
[
[
355,
54,
19223
],
[
19223,
15,
28
]
],
[
[
355,
21,
28809
],
[
28809,
60,
28
]
],
[
[
355,
23,
16
],
[
16,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Lactulose",
"{u} (Compound) is included by {v} (Pharmacologic Class)",
"Stimulation Large Intestine Fluid/Electrolyte Secretion"
]... | Lactulose (Compound) is included by Stimulation Large Intestine Fluid/Electrolyte Secretion (Pharmacologic Class) and Stimulation Large Intestine Fluid/Electrolyte Secretion (Pharmacologic Class) includes Bisacodyl (Compound)
Lactulose (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by B... |
DB00108 | DB14762 | 1,066 | 994 | [
"DDInter1268",
"DDInter1602"
] | Natalizumab | Risankizumab | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and Europe in April 2019. Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease... | Major | 2 | [
[
[
1066,
25,
994
]
],
[
[
1066,
23,
1114
],
[
1114,
23,
994
]
],
[
[
1066,
25,
4
],
[
4,
24,
994
]
],
[
[
1066,
64,
58
],
[
58,
24,... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Risankizumab"
]
],
[
[
"Natalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
"Zinc s... | Natalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Risankizumab
Natalizumab may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Om... |
DB00188 | DB14575 | 168 | 733 | [
"DDInter222",
"DDInter674"
] | Bortezomib | Eslicarbazepine | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Minor | 0 | [
[
[
168,
23,
733
]
],
[
[
168,
23,
1101
],
[
1101,
23,
733
]
],
[
[
168,
23,
985
],
[
985,
24,
733
]
],
[
[
168,
25,
129
],
[
129,
2... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
... | Bortezomib may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib and Osimer... |
DB00619 | DB06210 | 1,419 | 72 | [
"DDInter909",
"DDInter631"
] | Imatinib | Eltrombopag | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Moderate | 1 | [
[
[
1419,
24,
72
]
],
[
[
1419,
6,
7950
],
[
7950,
45,
72
]
],
[
[
1419,
24,
74
],
[
74,
62,
72
]
],
[
[
1419,
24,
384
],
[
384,
63,... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
]
],
[
[
"Imatinib",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Imatinib (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Eltrombopag (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Boceprevir and Boceprevir may cause a minor interaction that can limit clinical effects when taken with Eltrombopag
Imatinib may cause a m... |
DB01129 | DB12615 | 379 | 1,381 | [
"DDInter1559",
"DDInter1482"
] | Rabeprazole | Plazomicin | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from . The structure of plazomicin was established via appending hydroxylaminobutyric acid to at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglyco... | Moderate | 1 | [
[
[
379,
24,
1381
]
],
[
[
379,
62,
1479
],
[
1479,
24,
1381
]
],
[
[
379,
40,
837
],
[
837,
24,
1381
]
],
[
[
379,
24,
416
],
[
416,
... | [
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Plazomicin"
]
],
[
[
"Rabeprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetylsalicylic acid"
]... | Rabeprazole may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Plazomicin
Rabeprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole may cause a moderat... |
DB00104 | DB00731 | 966 | 1,144 | [
"DDInter1323",
"DDInter1269"
] | Octreotide | Nateglinide | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
966,
24,
1144
]
],
[
[
966,
21,
28787
],
[
28787,
60,
1144
]
],
[
[
966,
24,
17
],
[
17,
24,
1144
]
],
[
[
966,
24,
729
],
[
729,
... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Octreotide",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is c... | Octreotide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Nateglinide (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Nateglinid... |
DB00451 | DB00656 | 542 | 827 | [
"DDInter1064",
"DDInter1851"
] | Levothyroxine | Trazodone | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Minor | 0 | [
[
[
542,
23,
827
]
],
[
[
542,
6,
4973
],
[
4973,
45,
827
]
],
[
[
542,
21,
29118
],
[
29118,
60,
827
]
],
[
[
542,
24,
126
],
[
126,
... | [
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trazodone"
]
],
[
[
"Levothyroxine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)"... | Levothyroxine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Trazodone (Compound)
Levothyroxine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Trazodone (Compound)
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin a... |
DB00421 | DB11967 | 443 | 710 | [
"DDInter1707",
"DDInter210"
] | Spironolactone | Binimetinib | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
443,
24,
710
]
],
[
[
443,
24,
1619
],
[
1619,
63,
710
]
],
[
[
443,
24,
1220
],
[
1220,
24,
710
]
],
[
[
443,
1,
1561
],
[
1561,
... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
... | Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone ... |
DB01042 | DB01208 | 1,307 | 945 | [
"DDInter1144",
"DDInter1705"
] | Melphalan | Sparfloxacin | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Minor | 0 | [
[
[
1307,
23,
945
]
],
[
[
1307,
62,
739
],
[
739,
1,
945
]
],
[
[
1307,
23,
1539
],
[
1539,
1,
945
]
],
[
[
1307,
21,
28787
],
[
28787,
... | [
[
[
"Melphalan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Melphalan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Melphalan may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Melphalan may cause a minor interaction that can limit clinical effects when taken with Ofloxacin and Ofloxacin (Compound) resembles Sparfloxacin (Compound)
... |
DB01156 | DB01612 | 593 | 1,637 | [
"DDInter252",
"DDInter92"
] | Bupropion | Amyl Nitrite | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
593,
24,
1637
]
],
[
[
593,
25,
180
],
[
180,
63,
1637
]
],
[
[
593,
25,
993
],
[
993,
24,
1637
]
],
[
[
593,
64,
413
],
[
413,
... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oliceridine"
],
[
"Oliceridi... | Bupropion may lead to a major life threatening interaction when taken with Oliceridine and Oliceridine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Bupropion may lead to a major life threatening interaction when taken with Diamorphine and Diamorphine may cause a moderate ... |
DB00792 | DB11732 | 832 | 1,097 | [
"DDInter1878",
"DDInter1027"
] | Tripelennamine | Lasmiditan | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
832,
24,
1097
]
],
[
[
832,
63,
701
],
[
701,
24,
1097
]
],
[
[
832,
74,
662
],
[
662,
24,
1097
]
],
[
[
832,
35,
272
],
[
272,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Tripelennamine (Compound) resembles Carbinoxamine (Compound) and Tripelennamine may cause a moderate interac... |
DB00218 | DB11126 | 1,176 | 900 | [
"DDInter1247",
"DDInter276"
] | Moxifloxacin | Calcium gluconate | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Moderate | 1 | [
[
[
1176,
24,
900
]
],
[
[
1176,
1,
945
],
[
945,
24,
900
]
],
[
[
1176,
1,
945
],
[
945,
40,
739
],
[
739,
24,
900
]
],
[
[
1176,
1... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Sparfloxacin"
],
[
"Sparfloxacin",
"{u} may ... | Moxifloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Moxifloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin may cause ... |
DB01105 | DB11124 | 222 | 209 | [
"DDInter1665",
"DDInter1560"
] | Sibutramine | Racepinephrine | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Racepinephrine is a racemic mixture consisting of d- and l- enantiomers. Epinephrine is a non-selective α- and β-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including wheezing, tightness of chest and shortness of breath. It is an active ingred... | Moderate | 1 | [
[
[
222,
24,
209
]
],
[
[
222,
63,
688
],
[
688,
24,
209
]
],
[
[
222,
25,
22
],
[
22,
24,
209
]
],
[
[
222,
24,
1090
],
[
1090,
24,... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Racepinephrine"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Racepinephrine
Sibutramine may lead to a major life threatening interaction when taken with Ephedrine and Ephedrine may ca... |
DB01098 | DB13879 | 14 | 1,043 | [
"DDInter1622",
"DDInter824"
] | Rosuvastatin | Glecaprevir | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Glecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication. In combination with , glecaprevir is a useful therapy for patients who experienced therapeutic failure from other NS3/4A protease inhibitors. It demonstrates a high genetic ba... | Major | 2 | [
[
[
14,
25,
1043
]
],
[
[
14,
25,
466
],
[
466,
24,
1043
]
],
[
[
14,
24,
971
],
[
971,
24,
1043
]
],
[
[
14,
63,
629
],
[
629,
24,
... | [
[
[
"Rosuvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glecaprevir"
]
],
[
[
"Rosuvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Darolutamide"
],
[
"Darolutamide",
... | Rosuvastatin may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Glecaprevir
Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritin... |
DB00637 | DB00738 | 1,557 | 485 | [
"DDInter128",
"DDInter1420"
] | Astemizole | Pentamidine | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Moderate | 1 | [
[
[
1557,
24,
485
]
],
[
[
1557,
6,
12523
],
[
12523,
45,
485
]
],
[
[
1557,
7,
7669
],
[
7669,
46,
485
]
],
[
[
1557,
7,
9915
],
[
9915,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
]
],
[
[
"Astemizole",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)"... | Astemizole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pentamidine (Compound)
Astemizole (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Pentamidine (Compound)
Astemizole (Compound) upregulates LIPA (Gene) and LIPA (Gene) is downregulated by Pentamidine (Compound)
Astemizole may ... |
DB01611 | DB14568 | 1,487 | 982 | [
"DDInter893",
"DDInter1000"
] | Hydroxychloroquine | Ivosidenib | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1487,
25,
982
]
],
[
[
1487,
63,
112
],
[
112,
23,
982
]
],
[
[
1487,
62,
1247
],
[
1247,
23,
982
]
],
[
[
1487,
63,
700
],
[
700,
... | [
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Hydroxychloroquine may cause a minor interaction that can limit clinical effects when taken with Sul... |
DB11988 | DB13985 | 270 | 546 | [
"DDInter1321",
"DDInter1108"
] | Ocrelizumab | Lutetium Lu 177 dotatate | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting tumours with molecules carrying radioactive particles that bind to specific receptors expressed by the tumour. Lutetium Lu 177 dot... | Moderate | 1 | [
[
[
270,
24,
546
]
],
[
[
270,
63,
66
],
[
66,
24,
546
]
],
[
[
270,
64,
1057
],
[
1057,
25,
546
]
],
[
[
270,
63,
629
],
[
629,
25,... | [
[
[
"Ocrelizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lutetium Lu 177 dotatate"
]
],
[
[
"Ocrelizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"... | Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Lutetium Lu 177 dotatate
Ocrelizumab may lead to a major life threatening interaction when taken with Etanercept and Etane... |
DB00519 | DB09038 | 1,638 | 1,450 | [
"DDInter1843",
"DDInter636"
] | Trandolapril | Empagliflozin | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1638,
24,
1450
]
],
[
[
1638,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
1638,
24,
1486
],
[
1486,
24,
1450
]
],
[
[
1638,
24,
1455
],
[
14... | [
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],... | Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Methylpred... |
DB00241 | DB13074 | 288 | 877 | [
"DDInter257",
"DDInter1110"
] | Butalbital | Macimorelin | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
288,
24,
877
]
],
[
[
288,
24,
112
],
[
112,
23,
877
]
],
[
[
288,
24,
1320
],
[
1320,
24,
877
]
],
[
[
288,
23,
1101
],
[
1101,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Ela... |
DB00938 | DB08899 | 455 | 129 | [
"DDInter1635",
"DDInter649"
] | Salmeterol | Enzalutamide | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
455,
24,
129
]
],
[
[
455,
24,
918
],
[
918,
1,
129
]
],
[
[
455,
6,
8374
],
[
8374,
45,
129
]
],
[
[
455,
21,
29377
],
[
29377,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Salmeterol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Salmeterol (Compound) causes Musculoskeletal pain (Side Ef... |
DB00831 | DB09104 | 1,178 | 286 | [
"DDInter1866",
"DDInter1118"
] | Trifluoperazine | Magnesium hydroxide | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1178,
24,
286
]
],
[
[
1178,
35,
820
],
[
820,
23,
286
]
],
[
[
1178,
1,
146
],
[
146,
23,
286
]
],
[
[
1178,
63,
999
],
[
999,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Trifluoperazine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate di... | Trifluoperazine (Compound) resembles Alimemazine (Compound) and Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Trifluoperazine (Compound) resembl... |
DB00894 | DB04865 | 1,581 | 4 | [
"DDInter1774",
"DDInter1335"
] | Testolactone | Omacetaxine mepesuccinate | An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer. | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1581,
24,
4
]
],
[
[
1581,
1,
423
],
[
423,
24,
4
]
],
[
[
1581,
25,
350
],
[
350,
63,
4
]
],
[
[
1581,
40,
1547
],
[
1547,
24,
... | [
[
[
"Testolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Testolactone",
"{u} (Compound) resembles {v} (Compound)",
"Ciclesonide"
],
[
"Ciclesonide",
"{u... | Testolactone (Compound) resembles Ciclesonide (Compound) and Ciclesonide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Testolactone may lead to a major life threatening interaction when taken with Carfilzomib and Carfilzomib may cause a moderate interaction th... |
DB00526 | DB10583 | 1,555 | 949 | [
"DDInter1355",
"DDInter415"
] | Oxaliplatin | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
1555,
24,
949
]
],
[
[
1555,
63,
589
],
[
589,
24,
949
]
],
[
[
1555,
25,
1377
],
[
1377,
24,
949
]
],
[
[
1555,
24,
663
],
[
663,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Oxaliplatin may lead to a major life threatening interaction wh... |
DB00359 | DB00586 | 161 | 1,512 | [
"DDInter1721",
"DDInter537"
] | Sulfadiazine | Diclofenac | One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Moderate | 1 | [
[
[
161,
24,
1512
]
],
[
[
161,
6,
8374
],
[
8374,
45,
1512
]
],
[
[
161,
21,
28957
],
[
28957,
60,
1512
]
],
[
[
161,
24,
473
],
[
473,
... | [
[
[
"Sulfadiazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
]
],
[
[
"Sulfadiazine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Sulfadiazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Diclofenac (Compound)
Sulfadiazine (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Diclofenac (Compound)
Sulfadiazine may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide... |
DB00889 | DB12332 | 1,133 | 1,619 | [
"DDInter840",
"DDInter1626"
] | Granisetron | Rucaparib | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1133,
24,
1619
]
],
[
[
1133,
25,
222
],
[
222,
23,
1619
]
],
[
[
1133,
62,
307
],
[
307,
23,
1619
]
],
[
[
1133,
23,
112
],
[
112,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutram... | Granisetron may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Granisetron may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a m... |
DB00465 | DB09418 | 886 | 554 | [
"DDInter1010",
"DDInter1501"
] | Ketorolac | Potassium perchlorate | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Potassium perchlorate is an inorganic salt with the chemical formula KClO4. It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. Potassium is most commonly used in flares and automobile airbags . The use of potassium perchlorate as a component in sealing gaskets for food containers has b... | Moderate | 1 | [
[
[
886,
24,
554
]
],
[
[
886,
1,
935
],
[
935,
24,
554
]
],
[
[
886,
25,
1274
],
[
1274,
24,
554
]
],
[
[
886,
1,
935
],
[
935,
63,... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium perchlorate"
]
],
[
[
"Ketorolac",
"{u} (Compound) resembles {v} (Compound)",
"Ketoprofen"
],
[
"Ketoprofen",
"{u} may cause ... | Ketorolac (Compound) resembles Ketoprofen (Compound) and Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Potassium perchlorate
Ketorolac may lead to a major life threatening interaction when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could e... |
DB00348 | DB00615 | 254 | 690 | [
"DDInter1300",
"DDInter1589"
] | Nitisinone | Rifabutin | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Moderate | 1 | [
[
[
254,
24,
690
]
],
[
[
254,
24,
463
],
[
463,
1,
690
]
],
[
[
254,
21,
28852
],
[
28852,
60,
690
]
],
[
[
254,
63,
1101
],
[
1101,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rifampicin (Compound) resembles Rifabutin (Compound)
Nitisinone (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Rifabutin (Compound)
Nitisinone may cause a moderate interaction ... |
DB01236 | DB09268 | 679 | 1,662 | [
"DDInter1664",
"DDInter1464"
] | Sevoflurane | Picosulfuric acid | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
679,
24,
1662
]
],
[
[
679,
24,
484
],
[
484,
63,
1662
]
],
[
[
679,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
679,
24,
1491
],
[
1491,
... | [
[
[
"Sevoflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Sevoflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]... | Sevoflurane may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Sevoflurane may lead to a major life threatening interaction when taken with Cabozantinib and Cabozant... |
DB00030 | DB00443 | 1,685 | 251 | [
"DDInter934",
"DDInter195"
] | Insulin human | Betamethasone | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Moderate | 1 | [
[
[
1685,
24,
251
]
],
[
[
1685,
24,
870
],
[
870,
1,
251
]
],
[
[
1685,
24,
1486
],
[
1486,
40,
251
]
],
[
[
1685,
23,
1103
],
[
1103,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Betamethasone (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone (Compoun... |
DB00888 | DB11943 | 1,001 | 255 | [
"DDInter1133",
"DDInter495"
] | Mechlorethamine | Delafloxacin | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Minor | 0 | [
[
[
1001,
23,
255
]
],
[
[
1001,
63,
377
],
[
377,
23,
255
]
],
[
[
1001,
24,
995
],
[
995,
23,
255
]
],
[
[
1001,
40,
450
],
[
450,
... | [
[
[
"Mechlorethamine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Delafloxacin"
]
],
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mitomycin"
],... | Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyurea a... |
DB05260 | DB09134 | 1,329 | 1,552 | [
"DDInter804",
"DDInter966"
] | Gallium nitrate | Ioversol | Gallium nitrate is a nitrate salt of, a heavy metal that has been used as a diagnostic agent. Gallium nitrate is reported to possess antiresorptive and hypocalcemic effects on bone. GANITE, a product of gallium nitrate previously used to treat cancer-related hypercalcemia, was discontinued from marketing in the US for ... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Major | 2 | [
[
[
1329,
25,
1552
]
],
[
[
1329,
64,
1448
],
[
1448,
25,
1552
]
],
[
[
1329,
63,
372
],
[
372,
25,
1552
]
],
[
[
1329,
64,
1448
],
[
1448... | [
[
[
"Gallium nitrate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioversol"
]
],
[
[
"Gallium nitrate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Streptomycin"
],
[
"Streptomycin",
... | Gallium nitrate may lead to a major life threatening interaction when taken with Streptomycin and Streptomycin may lead to a major life threatening interaction when taken with Ioversol
Gallium nitrate may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may lead to... |
DB00193 | DB00366 | 534 | 1,594 | [
"DDInter1841",
"DDInter600"
] | Tramadol | Doxylamine | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Moderate | 1 | [
[
[
534,
24,
1594
]
],
[
[
534,
25,
11
],
[
11,
1,
1594
]
],
[
[
534,
24,
662
],
[
662,
63,
1594
]
],
[
[
534,
25,
1264
],
[
1264,
6... | [
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
]
],
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
],
[
"Toremifene",
... | Tramadol may lead to a major life threatening interaction when taken with Toremifene and Toremifene (Compound) resembles Doxylamine (Compound)
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate d... |
DB00373 | DB01377 | 461 | 1,283 | [
"DDInter1809",
"DDInter1119"
] | Timolol | Magnesium oxide | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
461,
23,
1283
]
],
[
[
461,
24,
167
],
[
167,
23,
1283
]
],
[
[
461,
1,
729
],
[
729,
23,
1283
]
],
[
[
461,
63,
999
],
[
999,
2... | [
[
[
"Timolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
[
... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Timolol (Compound) resembles Penbutolol (Compound) and Penbutolol may cause a minor interaction that can... |
DB00041 | DB00474 | 1,648 | 1,269 | [
"DDInter38",
"DDInter1173"
] | Aldesleukin | Methohexital | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia. | Moderate | 1 | [
[
[
1648,
24,
1269
]
],
[
[
1648,
24,
1023
],
[
1023,
1,
1269
]
],
[
[
1648,
24,
536
],
[
536,
40,
1269
]
],
[
[
1648,
24,
401
],
[
401,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methohexital"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentobarbital"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital and Pentobarbital (Compound) resembles Methohexital (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital (Compound) resembles Methohex... |
DB00812 | DB01234 | 998 | 1,220 | [
"DDInter1451",
"DDInter513"
] | Phenylbutazone | Dexamethasone | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
998,
24,
1220
]
],
[
[
998,
63,
870
],
[
870,
1,
1220
]
],
[
[
998,
63,
175
],
[
175,
40,
1220
]
],
[
[
998,
24,
617
],
[
617,
4... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resem... |
DB00507 | DB00563 | 316 | 663 | [
"DDInter1299",
"DDInter1174"
] | Nitazoxanide | Methotrexate | Nitazoxanide belongs to the class of drugs known as _thiazolides_. Nitazoxanide (NTZ) is a broad-spectrum anti-infective drug that markedly modulates the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, in addition to viruses.... | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
316,
24,
663
]
],
[
[
316,
7,
1720
],
[
1720,
46,
663
]
],
[
[
316,
18,
10699
],
[
10699,
57,
663
]
],
[
[
316,
21,
28681
],
[
28681,
... | [
[
[
"Nitazoxanide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Nitazoxanide",
"{u} (Compound) upregulates {v} (Gene)",
"RELB"
],
[
"RELB",
"{u} (Gene) is upregulated by {v... | Nitazoxanide (Compound) upregulates RELB (Gene) and RELB (Gene) is upregulated by Methotrexate (Compound)
Nitazoxanide (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is downregulated by Methotrexate (Compound)
Nitazoxanide (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is ... |
DB00619 | DB00696 | 1,419 | 826 | [
"DDInter909",
"DDInter665"
] | Imatinib | Ergotamine | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Moderate | 1 | [
[
[
1419,
24,
826
]
],
[
[
1419,
24,
469
],
[
469,
40,
826
]
],
[
[
1419,
63,
588
],
[
588,
1,
826
]
],
[
[
1419,
63,
1131
],
[
1131,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ergotamine"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromocriptine"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Bromocriptine and Bromocriptine (Compound) resembles Ergotamine (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Methylergometrine and Methylergometrine (Compound) resembles Ergota... |
DB00436 | DB11130 | 323 | 407 | [
"DDInter179",
"DDInter1344"
] | Bendroflumethiazide | Opium | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
323,
24,
407
]
],
[
[
323,
24,
849
],
[
849,
24,
407
]
],
[
[
323,
40,
178
],
[
178,
24,
407
]
],
[
[
323,
62,
352
],
[
352,
24,... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Bendroflumethiazide (Compound) resembles Polythiazide (Compound) and Polythiazide may cause a moderate inter... |
DB00983 | DB06764 | 480 | 1,090 | [
"DDInter776",
"DDInter1787"
] | Formoterol | Tetryzoline (nasal) | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Moderate | 1 | [
[
[
480,
24,
1090
]
],
[
[
480,
24,
1032
],
[
1032,
63,
1090
]
],
[
[
480,
24,
901
],
[
901,
24,
1090
]
],
[
[
480,
63,
1290
],
[
1290,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetryzoline"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
],
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol and Levosalbutamol may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
... |
DB00694 | DB00978 | 51 | 739 | [
"DDInter485",
"DDInter1084"
] | Daunorubicin | Lomefloxacin | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Minor | 0 | [
[
[
51,
23,
739
]
],
[
[
51,
25,
945
],
[
945,
40,
739
]
],
[
[
51,
24,
872
],
[
872,
40,
739
]
],
[
[
51,
64,
1176
],
[
1176,
1,
... | [
[
[
"Daunorubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
],
[
"Spar... | Daunorubicin may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Lomefloxacin (Compound)... |
DB01124 | DB06292 | 1,411 | 549 | [
"DDInter1828",
"DDInter474"
] | Tolbutamide | Dapagliflozin | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1411,
24,
549
]
],
[
[
1411,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1411,
6,
6017
],
[
6017,
45,
549
]
],
[
[
1411,
21,
29222
],
[
29222... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Tolbutamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dapagliflozin (Compound)
Tolbutamide (Compound) causes Hypoglycaemia (Side Ef... |
DB01105 | DB04948 | 222 | 1,084 | [
"DDInter1665",
"DDInter1083"
] | Sibutramine | Lofexidine | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
222,
24,
1084
]
],
[
[
222,
63,
1617
],
[
1617,
1,
1084
]
],
[
[
222,
63,
688
],
[
688,
24,
1084
]
],
[
[
222,
24,
392
],
[
392,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Lofexidine (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction th... |
DB01001 | DB06603 | 688 | 39 | [
"DDInter1632",
"DDInter1387"
] | Salbutamol | Panobinostat | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
688,
24,
39
]
],
[
[
688,
23,
1247
],
[
1247,
23,
39
]
],
[
[
688,
62,
112
],
[
112,
23,
39
]
],
[
[
688,
63,
479
],
[
479,
23,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Salbutamol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Salbutamol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Salbutamol may cause a minor interaction that can limit clinical effects when taken with Metronidazole... |
DB01591 | DB08865 | 667 | 1,593 | [
"DDInter1696",
"DDInter448"
] | Solifenacin | Crizotinib | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
667,
25,
1593
]
],
[
[
667,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
667,
21,
29093
],
[
29093,
60,
1593
]
],
[
[
667,
24,
283
],
[
283,
... | [
[
[
"Solifenacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Solifenacin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizo... | Solifenacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Solifenacin (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Crizotinib (Compound)
Solifenacin may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedra... |
DB06704 | DB09134 | 247 | 1,552 | [
"DDInter952",
"DDInter966"
] | Iobenguane (I-131) | Ioversol | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Major | 2 | [
[
[
247,
25,
1552
]
],
[
[
247,
64,
17
],
[
17,
24,
1552
]
],
[
[
247,
24,
242
],
[
242,
63,
1552
]
],
[
[
247,
76,
1523
],
[
1523,
... | [
[
[
"Iobenguane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioversol"
]
],
[
[
"Iobenguane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sotalol"
],
[
"Sotalol",
"{u} may cause... | Iobenguane may lead to a major life threatening interaction when taken with Ioversol
Iobenguane may lead to a major life threatening interaction when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Iobenguane may cause a moderate interaction that c... |
DB01284 | DB11601 | 1,042 | 1,270 | [
"DDInter1782",
"DDInter1889"
] | Tetracosactide | Tuberculin purified protein derivative | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
1042,
24,
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]
],
[
[
1042,
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],
[
1531,
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]
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[
[
1042,
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1064
],
[
1064,
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]
],
[
[
1042,
63,
599
],
[
599... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Tetracosactide may lead to a major life threatening interaction when taken wit... |
DB00443 | DB00834 | 251 | 932 | [
"DDInter195",
"DDInter1215"
] | Betamethasone | Mifepristone | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Major | 2 | [
[
[
251,
25,
932
]
],
[
[
251,
6,
1899
],
[
1899,
45,
932
]
],
[
[
251,
7,
2384
],
[
2384,
46,
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]
],
[
[
251,
18,
5057
],
[
5057,
... | [
[
[
"Betamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mifepristone"
]
],
[
[
"Betamethasone",
"{u} (Compound) binds {v} (Gene)",
"NR3C1"
],
[
"NR3C1",
"{u} (Gene) is bound by {v} (Compound)",
"M... | Betamethasone (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) is bound by Mifepristone (Compound)
Betamethasone (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Mifepristone (Compound)
Betamethasone (Compound) downregulates IL1B (Gene) and IL1B (Gene) is upregulated by Mifepristone (Compound)
Betamet... |
DB00197 | DB14761 | 1,324 | 242 | [
"DDInter1881",
"DDInter1578"
] | Troglitazone | Remdesivir | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1324,
24,
242
]
],
[
[
1324,
24,
1130
],
[
1130,
24,
242
]
],
[
[
1324,
25,
1377
],
[
1377,
24,
242
]
],
[
[
1324,
23,
1101
],
[
1101,... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Troglitazone may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide ... |
DB01211 | DB11757 | 609 | 960 | [
"DDInter393",
"DDInter994"
] | Clarithromycin | Istradefylline | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Istradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A<sub>2A</sub> receptors in the basal ganglia. This region of the brain is highly in... | Major | 2 | [
[
[
609,
25,
960
]
],
[
[
609,
25,
1135
],
[
1135,
23,
960
]
],
[
[
609,
63,
77
],
[
77,
24,
960
]
],
[
[
609,
24,
1499
],
[
1499,
2... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Istradefylline"
]
],
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Clarithromycin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Istradefylline
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin and Idarubicin ma... |
DB00006 | DB06603 | 942 | 39 | [
"DDInter217",
"DDInter1387"
] | Bivalirudin | Panobinostat | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
942,
25,
39
]
],
[
[
942,
24,
578
],
[
578,
63,
39
]
],
[
[
942,
24,
383
],
[
383,
24,
39
]
],
[
[
942,
25,
4
],
[
4,
24,
... | [
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
"Ticagr... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulf... |
DB00041 | DB01041 | 1,648 | 770 | [
"DDInter38",
"DDInter1789"
] | Aldesleukin | Thalidomide | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
1648,
25,
770
]
],
[
[
1648,
24,
4
],
[
4,
63,
770
]
],
[
[
1648,
24,
684
],
[
684,
24,
770
]
],
[
[
1648,
25,
876
],
[
876,
24,... | [
[
[
"Aldesleukin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
],
[... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Aldesleukin may cause a moderate interaction that could exacerbate diseases when... |
DB00448 | DB00758 | 1,215 | 1,347 | [
"DDInter1022",
"DDInter413"
] | Lansoprazole | Clopidogrel | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Moderate | 1 | [
[
[
1215,
24,
1347
]
],
[
[
1215,
6,
3486
],
[
3486,
45,
1347
]
],
[
[
1215,
18,
4602
],
[
4602,
46,
1347
]
],
[
[
1215,
21,
28744
],
[
28... | [
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
]
],
[
[
"Lansoprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compou... | Lansoprazole (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Clopidogrel (Compound)
Lansoprazole (Compound) downregulates SUPV3L1 (Gene) and SUPV3L1 (Gene) is upregulated by Clopidogrel (Compound)
Lansoprazole (Compound) causes Deafness (Side Effect) and Deafness (Side Effect) is caused by Clopidogrel (Com... |
DB00176 | DB00427 | 529 | 1,233 | [
"DDInter770",
"DDInter1879"
] | Fluvoxamine | Triprolidine | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Moderate | 1 | [
[
[
529,
24,
1233
]
],
[
[
529,
6,
12523
],
[
12523,
45,
1233
]
],
[
[
529,
24,
662
],
[
662,
63,
1233
]
],
[
[
529,
25,
506
],
[
506,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triprolidine"
]
],
[
[
"Fluvoxamine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compoun... | Fluvoxamine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Triprolidine (Compound)
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Fluvox... |
DB00927 | DB01118 | 1,559 | 33 | [
"DDInter712",
"DDInter76"
] | Famotidine | Amiodarone | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
1559,
24,
33
]
],
[
[
1559,
24,
540
],
[
540,
1,
33
]
],
[
[
1559,
6,
10215
],
[
10215,
45,
33
]
],
[
[
1559,
21,
28779
],
[
28779,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
],
[
... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Famotidine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Amiodarone (Compound)
Famotidine (Compound) causes Dry mouth (Side Effect) and Dry m... |
DB00712 | DB01021 | 1,274 | 674 | [
"DDInter763",
"DDInter1861"
] | Flurbiprofen | Trichlormethiazide | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Moderate | 1 | [
[
[
1274,
24,
674
]
],
[
[
1274,
63,
1014
],
[
1014,
40,
674
]
],
[
[
1274,
24,
178
],
[
178,
1,
674
]
],
[
[
1274,
24,
359
],
[
359,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazide"
... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles Tr... |
DB01611 | DB11730 | 1,487 | 351 | [
"DDInter893",
"DDInter1588"
] | Hydroxychloroquine | Ribociclib | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1487,
25,
351
]
],
[
[
1487,
62,
1247
],
[
1247,
23,
351
]
],
[
[
1487,
63,
112
],
[
112,
23,
351
]
],
[
[
1487,
24,
283
],
[
283,
... | [
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Hydroxychloroquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB11921 | DB14443 | 1,019 | 987 | [
"DDInter492",
"DDInter1931"
] | Deflazacort | Vibrio cholerae CVD 103-HgR strain live antigen | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
1019,
24,
987
]
],
[
[
1019,
64,
1220
],
[
1220,
24,
987
]
],
[
[
1019,
63,
305
],
[
305,
24,
987
]
],
[
[
1019,
24,
1619
],
[
1619,
... | [
[
[
"Deflazacort",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Deflazacort",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dex... | Deflazacort may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Deflazacort may cause a moderate interaction that could exacerbate diseases when ta... |
DB00213 | DB01602 | 837 | 339 | [
"DDInter1388",
"DDInter159"
] | Pantoprazole | Bacampicillin | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal ac... | Moderate | 1 | [
[
[
837,
24,
339
]
],
[
[
837,
1,
1215
],
[
1215,
24,
339
]
],
[
[
837,
24,
126
],
[
126,
24,
339
]
],
[
[
837,
25,
663
],
[
663,
25... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bacampicillin"
]
],
[
[
"Pantoprazole",
"{u} (Compound) resembles {v} (Compound)",
"Lansoprazole"
],
[
"Lansoprazole",
"{u} may caus... | Pantoprazole (Compound) resembles Lansoprazole (Compound) and Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Bacampicillin
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction tha... |
DB04868 | DB09046 | 478 | 1,094 | [
"DDInter1293",
"DDInter1201"
] | Nilotinib | Metreleptin | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Moderate | 1 | [
[
[
478,
24,
1094
]
],
[
[
478,
25,
230
],
[
230,
62,
1094
]
],
[
[
478,
63,
168
],
[
168,
23,
1094
]
],
[
[
478,
23,
1135
],
[
1135,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
]
],
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Relugolix"
],
[
"Relugolix",
... | Nilotinib may lead to a major life threatening interaction when taken with Relugolix and Relugolix may cause a minor interaction that can limit clinical effects when taken with Metreleptin
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a min... |
DB00222 | DB01021 | 245 | 674 | [
"DDInter825",
"DDInter1861"
] | Glimepiride | Trichlormethiazide | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Moderate | 1 | [
[
[
245,
24,
674
]
],
[
[
245,
24,
1014
],
[
1014,
40,
674
]
],
[
[
245,
24,
178
],
[
178,
1,
674
]
],
[
[
245,
24,
126
],
[
126,
23... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazide"
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles Tric... |
DB00374 | DB00622 | 1,061 | 1,081 | [
"DDInter1852",
"DDInter1287"
] | Treprostinil | Nicardipine | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Moderate | 1 | [
[
[
1061,
24,
1081
]
],
[
[
1061,
24,
409
],
[
409,
1,
1081
]
],
[
[
1061,
63,
1428
],
[
1428,
1,
1081
]
],
[
[
1061,
7,
7067
],
[
7067,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nicardipine"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
],
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Felodipine and Felodipine (Compound) resembles Nicardipine (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Nicardipine (Comp... |
DB01073 | DB08826 | 1,488 | 1,292 | [
"DDInter745",
"DDInter489"
] | Fludarabine | Deferiprone | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
1488,
25,
1292
]
],
[
[
1488,
21,
28809
],
[
28809,
60,
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]
],
[
[
1488,
63,
45
],
[
45,
24,
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]
],
[
[
1488,
40,
1426
],
[
1426... | [
[
[
"Fludarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Fludarabine",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) is caused by {v} (C... | Fludarabine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Deferiprone (Compound)
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Defe... |
DB00515 | DB00552 | 589 | 1,238 | [
"DDInter387",
"DDInter1425"
] | Cisplatin | Pentostatin | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Moderate | 1 | [
[
[
589,
24,
1238
]
],
[
[
589,
24,
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],
[
1477,
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],
[
[
589,
5,
11555
],
[
11555,
44,
1238
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],
[
[
589,
21,
28769
],
[
2876... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentostatin"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telbivudine"
],
[
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Telbivudine and Telbivudine (Compound) resembles Pentostatin (Compound)
Cisplatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Pentostatin (Compound)
Cisplatin (Compound) causes Fee... |
DB00059 | DB11827 | 1,560 | 433 | [
"DDInter1404",
"DDInter669"
] | Pegaspargase | Ertugliflozin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1560,
24,
433
]
],
[
[
1560,
25,
695
],
[
695,
24,
433
]
],
[
[
1560,
24,
959
],
[
959,
24,
433
]
],
[
[
1560,
63,
176
],
[
176,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Pegaspargase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
],
[
"Cloz... | Pegaspargase may lead to a major life threatening interaction when taken with Clozapine and Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cau... |
DB02701 | DB09054 | 1,632 | 384 | [
"DDInter1289",
"DDInter905"
] | Nicotinamide | Idelalisib | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1632,
24,
384
]
],
[
[
1632,
24,
1627
],
[
1627,
62,
384
]
],
[
[
1632,
63,
305
],
[
305,
24,
384
]
],
[
[
1632,
24,
242
],
[
242,
... | [
[
[
"Nicotinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Nicotinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
... | Nicotinamide may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Nicotinamide may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Esch... |
DB00286 | DB06777 | 380 | 780 | [
"DDInter439",
"DDInter348"
] | Conjugated estrogens | Chenodeoxycholic acid | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decre... | Moderate | 1 | [
[
[
380,
24,
780
]
],
[
[
380,
6,
8374
],
[
8374,
45,
780
]
],
[
[
380,
21,
28890
],
[
28890,
60,
780
]
],
[
[
380,
40,
890
],
[
890,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chenodeoxycholic acid"
]
],
[
[
"Conjugated estrogens",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gen... | Conjugated estrogens (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Chenodeoxycholic acid (Compound)
Conjugated estrogens (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Chenodeoxycholic acid (Compound)
Conjugated estrogens (Compound) resembles Me... |
DB00401 | DB06691 | 84 | 849 | [
"DDInter1298",
"DDInter1155"
] | Nisoldipine | Mepyramine | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
84,
24,
849
]
],
[
[
84,
24,
770
],
[
770,
24,
849
]
],
[
[
84,
63,
1648
],
[
1648,
24,
849
]
],
[
[
84,
40,
1428
],
[
1428,
24,... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
],
[... | Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and A... |
DB05812 | DB09098 | 1,374 | 98 | [
"DDInter8",
"DDInter1700"
] | Abiraterone | Somatrem | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1374,
24,
98
]
],
[
[
1374,
24,
1612
],
[
1612,
62,
98
]
],
[
[
1374,
63,
671
],
[
671,
24,
98
]
],
[
[
1374,
24,
159
],
[
159,
... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
[
... | Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Somatrem
Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluva... |
DB00065 | DB01177 | 581 | 77 | [
"DDInter923",
"DDInter904"
] | Infliximab | Idarubicin | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Major | 2 | [
[
[
581,
25,
77
]
],
[
[
581,
24,
112
],
[
112,
23,
77
]
],
[
[
581,
24,
496
],
[
496,
63,
77
]
],
[
[
581,
24,
1463
],
[
1463,
24,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idarubicin"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Idarubicin
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vacci... |
DB00208 | DB00363 | 1,018 | 695 | [
"DDInter1804",
"DDInter419"
] | Ticlopidine | Clozapine | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Major | 2 | [
[
[
1018,
25,
695
]
],
[
[
1018,
24,
902
],
[
902,
40,
695
]
],
[
[
1018,
6,
12523
],
[
12523,
45,
695
]
],
[
[
1018,
23,
286
],
[
286,
... | [
[
[
"Ticlopidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
]
],
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clobazam"
],
[
"Clobazam",
... | Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Clozapine (Compound)
Ticlopidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Clozapine (Compound)
Ticlopidine may cause a minor interaction that can limit clinical effe... |
DB00912 | DB06636 | 473 | 1,623 | [
"DDInter1581",
"DDInter980"
] | Repaglinide | Isavuconazonium | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
473,
24,
1623
]
],
[
[
473,
24,
466
],
[
466,
62,
1623
]
],
[
[
473,
24,
222
],
[
222,
23,
1623
]
],
[
[
473,
63,
1419
],
[
1419,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Isavuconazonium
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine ... |
DB01110 | DB08873 | 86 | 74 | [
"DDInter1209",
"DDInter221"
] | Miconazole | Boceprevir | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Moderate | 1 | [
[
[
86,
24,
74
]
],
[
[
86,
6,
4973
],
[
4973,
45,
74
]
],
[
[
86,
21,
28769
],
[
28769,
60,
74
]
],
[
[
86,
24,
310
],
[
310,
24,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Boceprevir"
]
],
[
[
"Miconazole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Miconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Boceprevir (Compound)
Miconazole (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Boceprevir (Compound)
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Cabazit... |
DB01284 | DB09043 | 1,042 | 135 | [
"DDInter1782",
"DDInter36"
] | Tetracosactide | Albiglutide | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
1042,
24,
135
]
],
[
[
1042,
63,
126
],
[
126,
23,
135
]
],
[
[
1042,
63,
519
],
[
519,
24,
135
]
],
[
[
1042,
62,
1052
],
[
1052,
... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and P... |
DB11853 | DB14568 | 230 | 982 | [
"DDInter1577",
"DDInter1000"
] | Relugolix | Ivosidenib | Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under th... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
230,
25,
982
]
],
[
[
230,
62,
112
],
[
112,
23,
982
]
],
[
[
230,
63,
28
],
[
28,
24,
982
]
],
[
[
230,
64,
1478
],
[
1478,
24,... | [
[
[
"Relugolix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Relugolix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazo... | Relugolix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Relugolix may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and Bisacod... |
DB00982 | DB14840 | 1,517 | 861 | [
"DDInter991",
"DDInter1601"
] | Isotretinoin | Ripretinib | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Moderate | 1 | [
[
[
1517,
24,
861
]
],
[
[
1517,
24,
214
],
[
214,
24,
861
]
],
[
[
1517,
64,
1101
],
[
1101,
24,
861
]
],
[
[
1517,
24,
384
],
[
384,
... | [
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ripretinib"
]
],
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
... | Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Isotretinoin may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene ma... |
DB00953 | DB01168 | 742 | 1,053 | [
"DDInter1611",
"DDInter1526"
] | Rizatriptan | Procarbazine | Rizatriptan is a second-generation triptan and a selective 5-HT<sub>1B and 5-HT1D</sub> receptor agonist. Used in the treatment of migraines, rizatriptan was first approved in the US in 1998. Rizatriptan is available in oral tablets, orally disintegrating tablets (wafers), and oral film formulations. | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Major | 2 | [
[
[
742,
25,
1053
]
],
[
[
742,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
742,
25,
1039
],
[
1039,
64,
1053
]
],
[
[
742,
64,
1494
],
[
1494... | [
[
[
"Rizatriptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procarbazine"
]
],
[
[
"Rizatriptan",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by {v} (Co... | Rizatriptan (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Rizatriptan may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may lead to a major life threatening interaction when taken with Procarbazine
Rizatriptan ... |
DB00218 | DB08870 | 1,176 | 850 | [
"DDInter1247",
"DDInter228"
] | Moxifloxacin | Brentuximab vedotin | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1176,
24,
850
]
],
[
[
1176,
23,
611
],
[
611,
24,
850
]
],
[
[
1176,
24,
267
],
[
267,
24,
850
]
],
[
[
1176,
25,
245
],
[
245,
... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dacarbazine"
... | Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Dacarbazine and Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Naltrexo... |
DB01132 | DB08912 | 1,130 | 1,040 | [
"DDInter1472",
"DDInter462"
] | Pioglitazone | Dabrafenib | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1130,
24,
1040
]
],
[
[
1130,
6,
13478
],
[
13478,
45,
1040
]
],
[
[
1130,
7,
4698
],
[
4698,
46,
1040
]
],
[
[
1130,
6,
4789
],
[
478... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Pioglitazone",
"{u} (Compound) binds {v} (Gene)",
"SLCO1B3"
],
[
"SLCO1B3",
"{u} (Gene) is bound by {v} (Compo... | Pioglitazone (Compound) binds SLCO1B3 (Gene) and SLCO1B3 (Gene) is bound by Dabrafenib (Compound)
Pioglitazone (Compound) upregulates GPC1 (Gene) and GPC1 (Gene) is upregulated by Dabrafenib (Compound)
Pioglitazone (Compound) binds PPARG (Gene) and PPARG (Gene) is downregulated by Dabrafenib (Compound)
Pioglitazone (Co... |
DB06207 | DB06595 | 910 | 1,491 | [
"DDInter1667",
"DDInter1214"
] | Silodosin | Midostaurin | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
910,
24,
1491
]
],
[
[
910,
24,
1017
],
[
1017,
63,
1491
]
],
[
[
910,
63,
1424
],
[
1424,
24,
1491
]
],
[
[
910,
24,
1250
],
[
1250,
... | [
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
... | Silodosin may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Silodosin may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine ma... |
DB00814 | DB06715 | 1,171 | 239 | [
"DDInter1143",
"DDInter1500"
] | Meloxicam | Potassium Iodide | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperthyroidism (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyr... | Moderate | 1 | [
[
[
1171,
24,
239
]
],
[
[
1171,
21,
29196
],
[
29196,
60,
239
]
],
[
[
1171,
24,
877
],
[
877,
63,
239
]
],
[
[
1171,
63,
1274
],
[
1274,... | [
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium Iodide"
]
],
[
[
"Meloxicam",
"{u} (Compound) causes {v} (Side Effect)",
"Paraesthesia"
],
[
"Paraesthesia",
"{u} (Side Effec... | Meloxicam (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Potassium Iodide (Compound)
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin and Macimorelin may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00286 | DB00443 | 380 | 251 | [
"DDInter439",
"DDInter195"
] | Conjugated estrogens | Betamethasone | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Moderate | 1 | [
[
[
380,
24,
251
]
],
[
[
380,
24,
617
],
[
617,
40,
251
]
],
[
[
380,
24,
870
],
[
870,
1,
251
]
],
[
[
380,
6,
8374
],
[
8374,
45,... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bude... | Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Betamethasone (Compound)
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound)... |
DB01068 | DB09241 | 1,565 | 1,629 | [
"DDInter411",
"DDInter1186"
] | Clonazepam | Methylene blue | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Moderate | 1 | [
[
[
1565,
24,
1629
]
],
[
[
1565,
24,
1311
],
[
1311,
24,
1629
]
],
[
[
1565,
24,
593
],
[
593,
25,
1629
]
],
[
[
1565,
24,
407
],
[
407,
... | [
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylene blue"
]
],
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
... | Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Bupropion... |
DB01097 | DB11834 | 1,377 | 1,303 | [
"DDInter1033",
"DDInter849"
] | Leflunomide | Guselkumab | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Major | 2 | [
[
[
1377,
25,
1303
]
],
[
[
1377,
23,
1193
],
[
1193,
23,
1303
]
],
[
[
1377,
62,
1461
],
[
1461,
23,
1303
]
],
[
[
1377,
24,
949
],
[
949... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Guselkumab"
]
],
[
[
"Leflunomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc g... | Leflunomide may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Guselkumab
Leflunomide may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vit... |
DB00396 | DB06335 | 989 | 761 | [
"DDInter1529",
"DDInter1646"
] | Progesterone | Saxagliptin | Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss. Progesterone is used in var... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
989,
24,
761
]
],
[
[
989,
6,
10417
],
[
10417,
45,
761
]
],
[
[
989,
21,
28966
],
[
28966,
60,
761
]
],
[
[
989,
24,
1296
],
[
1296,
... | [
[
[
"Progesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Progesterone",
"{u} (Compound) binds {v} (Gene)",
"ABCC1"
],
[
"ABCC1",
"{u} (Gene) is bound by {v} (Compound... | Progesterone (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Saxagliptin (Compound)
Progesterone (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Saxagliptin (Compound)
Progesterone may cause a moderate interaction that could e... |
DB01234 | DB14550 | 1,220 | 821 | [
"DDInter513",
"DDInter803"
] | Dexamethasone | Gallium chloride Ga-67 | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Gallium chloride Ga-67 is the chloride salt of a gallium radioisotope which is typically complexed with [sodium citrate] to generate [gallium citrate Ga 67], which can be used to image certain cancers and inflammatory lesions. | Moderate | 1 | [
[
[
1220,
24,
821
]
],
[
[
1220,
63,
663
],
[
663,
24,
821
]
],
[
[
1220,
40,
251
],
[
251,
24,
821
]
],
[
[
1220,
1,
617
],
[
617,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gallium chloride Ga-67"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrex... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Gallium chloride Ga-67
Dexamethasone (Compound) resembles Betamethasone (Compound) and Betamethasone may cause a mod... |
DB00524 | DB09104 | 811 | 286 | [
"DDInter1199",
"DDInter1118"
] | Metolazone | Magnesium hydroxide | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
811,
24,
286
]
],
[
[
811,
24,
820
],
[
820,
23,
286
]
],
[
[
811,
63,
999
],
[
999,
23,
286
]
],
[
[
811,
24,
688
],
[
688,
24,... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]... | Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylpera... |
DB09065 | DB12364 | 760 | 1,421 | [
"DDInter424",
"DDInter200"
] | Cobicistat | Betrixaban | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
760,
24,
1421
]
],
[
[
760,
63,
1091
],
[
1091,
24,
1421
]
],
[
[
760,
25,
1017
],
[
1017,
24,
1421
]
],
[
[
760,
64,
759
],
[
759,
... | [
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
],
[
... | Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Cobicistat may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may cause ... |
DB00361 | DB09074 | 134 | 1,362 | [
"DDInter1939",
"DDInter1327"
] | Vinorelbine | Olaparib | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
134,
24,
1362
]
],
[
[
134,
24,
725
],
[
725,
63,
1362
]
],
[
[
134,
24,
896
],
[
896,
24,
1362
]
],
[
[
134,
63,
552
],
[
552,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Satralizumab"
],
[
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab and Satralizumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Eto... |
DB00390 | DB01172 | 1,252 | 416 | [
"DDInter554",
"DDInter1004"
] | Digoxin | Kanamycin | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Minor | 0 | [
[
[
1252,
23,
416
]
],
[
[
1252,
63,
1647
],
[
1647,
1,
416
]
],
[
[
1252,
7,
7245
],
[
7245,
46,
416
]
],
[
[
1252,
18,
4930
],
[
4930,
... | [
[
[
"Digoxin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Kanamycin"
]
],
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[
"Acarbo... | Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose (Compound) resembles Kanamycin (Compound)
Digoxin (Compound) upregulates SSBP2 (Gene) and SSBP2 (Gene) is upregulated by Kanamycin (Compound)
Digoxin (Compound) downregulates DLD (Gene) and DLD (Gene) is downre... |
DB00601 | DB00731 | 453 | 1,144 | [
"DDInter1073",
"DDInter1269"
] | Linezolid | Nateglinide | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
453,
24,
1144
]
],
[
[
453,
63,
168
],
[
168,
24,
1144
]
],
[
[
453,
21,
28787
],
[
28787,
60,
1144
]
],
[
[
453,
64,
121
],
[
121,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide
Linezolid (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Nateglinide (Comp... |
DB01128 | DB04953 | 918 | 495 | [
"DDInter204",
"DDInter708"
] | Bicalutamide | Ezogabine | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Moderate | 1 | [
[
[
918,
24,
495
]
],
[
[
918,
21,
28787
],
[
28787,
60,
495
]
],
[
[
918,
23,
1135
],
[
1135,
62,
495
]
],
[
[
918,
62,
112
],
[
112,
... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ezogabine"
]
],
[
[
"Bicalutamide",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is... | Bicalutamide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Ezogabine (Compound)
Bicalutamide may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Ezogabin... |
DB00656 | DB00719 | 827 | 1,219 | [
"DDInter1851",
"DDInter149"
] | Trazodone | Azatadine | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
827,
24,
1219
]
],
[
[
827,
63,
13
],
[
13,
24,
1219
]
],
[
[
827,
24,
830
],
[
830,
1,
1219
]
],
[
[
827,
40,
695
],
[
695,
24,... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
[
... | Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and... |
DB01115 | DB12364 | 336 | 1,421 | [
"DDInter1291",
"DDInter200"
] | Nifedipine | Betrixaban | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
336,
24,
1421
]
],
[
[
336,
24,
1017
],
[
1017,
24,
1421
]
],
[
[
336,
25,
913
],
[
913,
24,
1421
]
],
[
[
336,
63,
714
],
[
714,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
... | Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Nifedipine may lead to a major life threatening interaction when taken with Apalutamide and Apalutamide may caus... |
DB00445 | DB11601 | 322 | 1,270 | [
"DDInter655",
"DDInter1889"
] | Epirubicin | Tuberculin purified protein derivative | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
322,
24,
1270
]
],
[
[
322,
64,
550
],
[
550,
24,
1270
]
],
[
[
322,
24,
1531
],
[
1531,
24,
1270
]
],
[
[
322,
63,
329
],
[
329,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trastuzumab"
... | Epirubicin may lead to a major life threatening interaction when taken with Trastuzumab and Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Canaki... |
DB00983 | DB01124 | 480 | 1,411 | [
"DDInter776",
"DDInter1828"
] | Formoterol | Tolbutamide | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
480,
24,
1411
]
],
[
[
480,
24,
959
],
[
959,
40,
1411
]
],
[
[
480,
63,
245
],
[
245,
40,
1411
]
],
[
[
480,
6,
10215
],
[
10215,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound... |
DB01222 | DB09381 | 617 | 192 | [
"DDInter246",
"DDInter678"
] | Budesonide | Esterified estrogens | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
617,
24,
192
]
],
[
[
617,
23,
771
],
[
771,
62,
192
]
],
[
[
617,
63,
723
],
[
723,
24,
192
]
],
[
[
617,
24,
283
],
[
283,
63,... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Budesonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
... | Budesonide may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Esterified estrogens
Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Aprepitan... |
DB00331 | DB00722 | 1,645 | 743 | [
"DDInter1164",
"DDInter1079"
] | Metformin | Lisinopril | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | Moderate | 1 | [
[
[
1645,
24,
743
]
],
[
[
1645,
24,
610
],
[
610,
40,
743
]
],
[
[
1645,
24,
1638
],
[
1638,
1,
743
]
],
[
[
1645,
21,
28691
],
[
28691,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Lisinopril (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Lisinopril (Compound)
... |
DB08895 | DB11979 | 976 | 1,320 | [
"DDInter1825",
"DDInter625"
] | Tofacitinib | Elagolix | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
976,
24,
1320
]
],
[
[
976,
64,
168
],
[
168,
23,
1320
]
],
[
[
976,
63,
608
],
[
608,
23,
1320
]
],
[
[
976,
24,
1297
],
[
1297,
... | [
[
[
"Tofacitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezomib... | Tofacitinib may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a mi... |
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