id stringlengths 1 5 | contents stringlengths 354 1.98k |
|---|---|
21600 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
And they boast a brilliant record against the Blues of late, winning six out of their last seven meetings.
They have triumphed in their last three trips to Stamford Bridge, and haven't lost in a London derby since May 2022.
As for Chelsea, they go into their match against the Gunners hopeful of a result having won their last three games in all competitions.
Both teams face injury doubts, with Arsenal to potentially be without Bukayo Saka and William Saliba, while it remains to be seen if Reece James and Armando Broja feature for the hosts.
9 Saka missed Arsenal's 1-0 victory over City at the Emirates last time out Credit: Getty
Sheffield United desperate for points against lacklustre Manchester United
With just one point on the board, Sheffield United's season could not be going much worse given they are rock bottom.
With a fixture against Manchester United on the cards, though, they may feel their hopes could be looking up given Erik ten Hag's men disappointing season. |
21601 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
They have triumphed in their last three trips to Stamford Bridge, and haven't lost in a London derby since May 2022.
As for Chelsea, they go into their match against the Gunners hopeful of a result having won their last three games in all competitions.
Both teams face injury doubts, with Arsenal to potentially be without Bukayo Saka and William Saliba, while it remains to be seen if Reece James and Armando Broja feature for the hosts.
9 Saka missed Arsenal's 1-0 victory over City at the Emirates last time out Credit: Getty
Sheffield United desperate for points against lacklustre Manchester United
With just one point on the board, Sheffield United's season could not be going much worse given they are rock bottom.
With a fixture against Manchester United on the cards, though, they may feel their hopes could be looking up given Erik ten Hag's men disappointing season.
They sit tenth in the table having won four and lost as many from their opening eight games. |
21602 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
As for Chelsea, they go into their match against the Gunners hopeful of a result having won their last three games in all competitions.
Both teams face injury doubts, with Arsenal to potentially be without Bukayo Saka and William Saliba, while it remains to be seen if Reece James and Armando Broja feature for the hosts.
9 Saka missed Arsenal's 1-0 victory over City at the Emirates last time out Credit: Getty
Sheffield United desperate for points against lacklustre Manchester United
With just one point on the board, Sheffield United's season could not be going much worse given they are rock bottom.
With a fixture against Manchester United on the cards, though, they may feel their hopes could be looking up given Erik ten Hag's men disappointing season.
They sit tenth in the table having won four and lost as many from their opening eight games.
But their most recent Premier League victory over Brentford may give the Red Devils hope their season is on the up. |
21603 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
As for Chelsea, they go into their match against the Gunners hopeful of a result having won their last three games in all competitions.
Both teams face injury doubts, with Arsenal to potentially be without Bukayo Saka and William Saliba, while it remains to be seen if Reece James and Armando Broja feature for the hosts.
9 Saka missed Arsenal's 1-0 victory over City at the Emirates last time out Credit: Getty
Sheffield United desperate for points against lacklustre Manchester United
With just one point on the board, Sheffield United's season could not be going much worse given they are rock bottom.
With a fixture against Manchester United on the cards, though, they may feel their hopes could be looking up given Erik ten Hag's men disappointing season.
They sit tenth in the table having won four and lost as many from their opening eight games.
But their most recent Premier League victory over Brentford may give the Red Devils hope their season is on the up.
Sheffield United vs Manchester United is live on talkSPORT - kick off is at 8:00pm
9 United got a dramatic win over Brentford before the international break Credit: Getty
An England vs South Africa double header
If you've had your football fix for the day, there's also a packed Saturday of rugby and cricket. |
21604 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
With a fixture against Manchester United on the cards, though, they may feel their hopes could be looking up given Erik ten Hag's men disappointing season.
They sit tenth in the table having won four and lost as many from their opening eight games.
But their most recent Premier League victory over Brentford may give the Red Devils hope their season is on the up.
Sheffield United vs Manchester United is live on talkSPORT - kick off is at 8:00pm
9 United got a dramatic win over Brentford before the international break Credit: Getty
An England vs South Africa double header
If you've had your football fix for the day, there's also a packed Saturday of rugby and cricket.
It's crunch time for England in the World Cups as they face South Africa in the semi-final of the Rugby World Cup and in the ODI Cricket World Cup. |
21605 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
With a fixture against Manchester United on the cards, though, they may feel their hopes could be looking up given Erik ten Hag's men disappointing season.
They sit tenth in the table having won four and lost as many from their opening eight games.
But their most recent Premier League victory over Brentford may give the Red Devils hope their season is on the up.
Sheffield United vs Manchester United is live on talkSPORT - kick off is at 8:00pm
9 United got a dramatic win over Brentford before the international break Credit: Getty
An England vs South Africa double header
If you've had your football fix for the day, there's also a packed Saturday of rugby and cricket.
It's crunch time for England in the World Cups as they face South Africa in the semi-final of the Rugby World Cup and in the ODI Cricket World Cup.
After England secured victory over Fiji in the quarter-finals, they now look to overcome defending champions South Africa to advance into their second consecutive Rugby World Cup final. |
21606 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
They sit tenth in the table having won four and lost as many from their opening eight games.
But their most recent Premier League victory over Brentford may give the Red Devils hope their season is on the up.
Sheffield United vs Manchester United is live on talkSPORT - kick off is at 8:00pm
9 United got a dramatic win over Brentford before the international break Credit: Getty
An England vs South Africa double header
If you've had your football fix for the day, there's also a packed Saturday of rugby and cricket.
It's crunch time for England in the World Cups as they face South Africa in the semi-final of the Rugby World Cup and in the ODI Cricket World Cup.
After England secured victory over Fiji in the quarter-finals, they now look to overcome defending champions South Africa to advance into their second consecutive Rugby World Cup final.
talkSPORT will have updates from all the action in Paris as England take on the Springboks from 8:00pm
9 Owen Farrell will be looking to inspire England to victory against the Springboks Credit: Getty
Over in India, England's Cricket World Cup hopes hang by a thread after their latest shock defeat to Afghanistan. |
21607 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
It's crunch time for England in the World Cups as they face South Africa in the semi-final of the Rugby World Cup and in the ODI Cricket World Cup.
After England secured victory over Fiji in the quarter-finals, they now look to overcome defending champions South Africa to advance into their second consecutive Rugby World Cup final.
talkSPORT will have updates from all the action in Paris as England take on the Springboks from 8:00pm
9 Owen Farrell will be looking to inspire England to victory against the Springboks Credit: Getty
Over in India, England's Cricket World Cup hopes hang by a thread after their latest shock defeat to Afghanistan.
They will be boosted by the news that Ben Stokes is fit for the match after he picked up a hip injury five days before the tournament.
But victory for England could scarcely be more crucial.
Having also lost to New Zealand in their opener, their chances of finishing in the top four and progressing to the semi-finals are looking dubious. |
21608 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
It's crunch time for England in the World Cups as they face South Africa in the semi-final of the Rugby World Cup and in the ODI Cricket World Cup.
After England secured victory over Fiji in the quarter-finals, they now look to overcome defending champions South Africa to advance into their second consecutive Rugby World Cup final.
talkSPORT will have updates from all the action in Paris as England take on the Springboks from 8:00pm
9 Owen Farrell will be looking to inspire England to victory against the Springboks Credit: Getty
Over in India, England's Cricket World Cup hopes hang by a thread after their latest shock defeat to Afghanistan.
They will be boosted by the news that Ben Stokes is fit for the match after he picked up a hip injury five days before the tournament.
But victory for England could scarcely be more crucial.
Having also lost to New Zealand in their opener, their chances of finishing in the top four and progressing to the semi-finals are looking dubious.
But South Africa, despite winning their first two games, suffered a shock defeat to the Netherlands in their most recent match - a sign for England that the Proteas can be beaten. |
21609 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
talkSPORT will have updates from all the action in Paris as England take on the Springboks from 8:00pm
9 Owen Farrell will be looking to inspire England to victory against the Springboks Credit: Getty
Over in India, England's Cricket World Cup hopes hang by a thread after their latest shock defeat to Afghanistan.
They will be boosted by the news that Ben Stokes is fit for the match after he picked up a hip injury five days before the tournament.
But victory for England could scarcely be more crucial.
Having also lost to New Zealand in their opener, their chances of finishing in the top four and progressing to the semi-finals are looking dubious.
But South Africa, despite winning their first two games, suffered a shock defeat to the Netherlands in their most recent match - a sign for England that the Proteas can be beaten.
talkSPORT will bring you updates as England take on South Africa in the Cricket World Cup in Mumbai from 9:30am
9 It's not looking good for England's cricketers
UFC 294 in Abu Dhabi
Islam Makhachev is hoping to to successfully defend his UFC lightweight belt against Alexander Volkanovski at UFC 294. |
21610 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
They will be boosted by the news that Ben Stokes is fit for the match after he picked up a hip injury five days before the tournament.
But victory for England could scarcely be more crucial.
Having also lost to New Zealand in their opener, their chances of finishing in the top four and progressing to the semi-finals are looking dubious.
But South Africa, despite winning their first two games, suffered a shock defeat to the Netherlands in their most recent match - a sign for England that the Proteas can be beaten.
talkSPORT will bring you updates as England take on South Africa in the Cricket World Cup in Mumbai from 9:30am
9 It's not looking good for England's cricketers
UFC 294 in Abu Dhabi
Islam Makhachev is hoping to to successfully defend his UFC lightweight belt against Alexander Volkanovski at UFC 294.
Makhachev retained his title in February this year as he defeated Volkanovski by a unanimous decision. |
21611 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
They will be boosted by the news that Ben Stokes is fit for the match after he picked up a hip injury five days before the tournament.
But victory for England could scarcely be more crucial.
Having also lost to New Zealand in their opener, their chances of finishing in the top four and progressing to the semi-finals are looking dubious.
But South Africa, despite winning their first two games, suffered a shock defeat to the Netherlands in their most recent match - a sign for England that the Proteas can be beaten.
talkSPORT will bring you updates as England take on South Africa in the Cricket World Cup in Mumbai from 9:30am
9 It's not looking good for England's cricketers
UFC 294 in Abu Dhabi
Islam Makhachev is hoping to to successfully defend his UFC lightweight belt against Alexander Volkanovski at UFC 294.
Makhachev retained his title in February this year as he defeated Volkanovski by a unanimous decision.
But despite the Russian's favourable 24-1-0 record, Volkanovski will be desperate to add the lightweight belt to his featherweight title. |
21612 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
Having also lost to New Zealand in their opener, their chances of finishing in the top four and progressing to the semi-finals are looking dubious.
But South Africa, despite winning their first two games, suffered a shock defeat to the Netherlands in their most recent match - a sign for England that the Proteas can be beaten.
talkSPORT will bring you updates as England take on South Africa in the Cricket World Cup in Mumbai from 9:30am
9 It's not looking good for England's cricketers
UFC 294 in Abu Dhabi
Islam Makhachev is hoping to to successfully defend his UFC lightweight belt against Alexander Volkanovski at UFC 294.
Makhachev retained his title in February this year as he defeated Volkanovski by a unanimous decision.
But despite the Russian's favourable 24-1-0 record, Volkanovski will be desperate to add the lightweight belt to his featherweight title.
Also on the cards, Kamaru Usman will fight Khamzat Chimaev in a middleweight title eliminator. |
21613 | Liverpool vs Everton begins epic Saturday with World Cup semi-final as well as Chelsea vs Arsenal – and it could end with a bang
But South Africa, despite winning their first two games, suffered a shock defeat to the Netherlands in their most recent match - a sign for England that the Proteas can be beaten.
talkSPORT will bring you updates as England take on South Africa in the Cricket World Cup in Mumbai from 9:30am
9 It's not looking good for England's cricketers
UFC 294 in Abu Dhabi
Islam Makhachev is hoping to to successfully defend his UFC lightweight belt against Alexander Volkanovski at UFC 294.
Makhachev retained his title in February this year as he defeated Volkanovski by a unanimous decision.
But despite the Russian's favourable 24-1-0 record, Volkanovski will be desperate to add the lightweight belt to his featherweight title.
Also on the cards, Kamaru Usman will fight Khamzat Chimaev in a middleweight title eliminator.
Expect fireworks. |
21614 | Deft is building e-commerce search to help you find the right product quickly
E-commerce search startup Deft is releasing a multimodal search function for users to get better results. The company, which opened its service to beta users in May, has rolled out the new search experience so users don’t have to describe the item in words.
The company is trying to solve the problem of finding the right item without spending hours looking for a product. Often users end up with subpar results while searching for products because their search query description won’t match the details of listed items. The startup is relying on different techniques, including building its own parser and knowledge graph combined with large language models (LLMs) and multimodal search.
Deft was founded in 2019 by Alex Gunnarson and Zach Hudson. Gunnarson started working on the idea after he couldn’t find a specific type of couch online even after putting in different parameters and descriptions. It took him hours to find a perfect result for his search, so Gunnarson decided to build a solution with Hudson. |
21615 | Deft is building e-commerce search to help you find the right product quickly
The company, which opened its service to beta users in May, has rolled out the new search experience so users don’t have to describe the item in words.
The company is trying to solve the problem of finding the right item without spending hours looking for a product. Often users end up with subpar results while searching for products because their search query description won’t match the details of listed items. The startup is relying on different techniques, including building its own parser and knowledge graph combined with large language models (LLMs) and multimodal search.
Deft was founded in 2019 by Alex Gunnarson and Zach Hudson. Gunnarson started working on the idea after he couldn’t find a specific type of couch online even after putting in different parameters and descriptions. It took him hours to find a perfect result for his search, so Gunnarson decided to build a solution with Hudson.
Users can go to Deft and search for things like “wooden lamps with three legs under $400” or upload an image, and modify their search to “lamps under $400 that look like this.” While it’s hard to know you can do this if someone doesn’t tell you that it works, users can also paste the image directly into the search bar. |
21616 | Deft is building e-commerce search to help you find the right product quickly
The startup is relying on different techniques, including building its own parser and knowledge graph combined with large language models (LLMs) and multimodal search.
Deft was founded in 2019 by Alex Gunnarson and Zach Hudson. Gunnarson started working on the idea after he couldn’t find a specific type of couch online even after putting in different parameters and descriptions. It took him hours to find a perfect result for his search, so Gunnarson decided to build a solution with Hudson.
Users can go to Deft and search for things like “wooden lamps with three legs under $400” or upload an image, and modify their search to “lamps under $400 that look like this.” While it’s hard to know you can do this if someone doesn’t tell you that it works, users can also paste the image directly into the search bar. The company is working on highlighting the image search feature better.
The company said that it doesn’t just look at the listing and description for search results. |
21617 | Deft is building e-commerce search to help you find the right product quickly
Deft was founded in 2019 by Alex Gunnarson and Zach Hudson. Gunnarson started working on the idea after he couldn’t find a specific type of couch online even after putting in different parameters and descriptions. It took him hours to find a perfect result for his search, so Gunnarson decided to build a solution with Hudson.
Users can go to Deft and search for things like “wooden lamps with three legs under $400” or upload an image, and modify their search to “lamps under $400 that look like this.” While it’s hard to know you can do this if someone doesn’t tell you that it works, users can also paste the image directly into the search bar. The company is working on highlighting the image search feature better.
The company said that it doesn’t just look at the listing and description for search results. It also looks at materials, reviews, photos and more. |
21618 | Deft is building e-commerce search to help you find the right product quickly
Deft was founded in 2019 by Alex Gunnarson and Zach Hudson. Gunnarson started working on the idea after he couldn’t find a specific type of couch online even after putting in different parameters and descriptions. It took him hours to find a perfect result for his search, so Gunnarson decided to build a solution with Hudson.
Users can go to Deft and search for things like “wooden lamps with three legs under $400” or upload an image, and modify their search to “lamps under $400 that look like this.” While it’s hard to know you can do this if someone doesn’t tell you that it works, users can also paste the image directly into the search bar. The company is working on highlighting the image search feature better.
The company said that it doesn’t just look at the listing and description for search results. It also looks at materials, reviews, photos and more. This way, when someone searches for a “pet-friendly” couch, Deft can return results with stain and scratch-resistant material. |
21619 | Deft is building e-commerce search to help you find the right product quickly
It took him hours to find a perfect result for his search, so Gunnarson decided to build a solution with Hudson.
Users can go to Deft and search for things like “wooden lamps with three legs under $400” or upload an image, and modify their search to “lamps under $400 that look like this.” While it’s hard to know you can do this if someone doesn’t tell you that it works, users can also paste the image directly into the search bar. The company is working on highlighting the image search feature better.
The company said that it doesn’t just look at the listing and description for search results. It also looks at materials, reviews, photos and more. This way, when someone searches for a “pet-friendly” couch, Deft can return results with stain and scratch-resistant material.
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars.” Zach Hudson
Deft is currently focusing on furniture and home décor search but aims to expand to different categories along the way. |
21620 | Deft is building e-commerce search to help you find the right product quickly
Users can go to Deft and search for things like “wooden lamps with three legs under $400” or upload an image, and modify their search to “lamps under $400 that look like this.” While it’s hard to know you can do this if someone doesn’t tell you that it works, users can also paste the image directly into the search bar. The company is working on highlighting the image search feature better.
The company said that it doesn’t just look at the listing and description for search results. It also looks at materials, reviews, photos and more. This way, when someone searches for a “pet-friendly” couch, Deft can return results with stain and scratch-resistant material.
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars.” Zach Hudson
Deft is currently focusing on furniture and home décor search but aims to expand to different categories along the way. The company has built its own scraping tech to add products to its search results. |
21621 | Deft is building e-commerce search to help you find the right product quickly
The company is working on highlighting the image search feature better.
The company said that it doesn’t just look at the listing and description for search results. It also looks at materials, reviews, photos and more. This way, when someone searches for a “pet-friendly” couch, Deft can return results with stain and scratch-resistant material.
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars.” Zach Hudson
Deft is currently focusing on furniture and home décor search but aims to expand to different categories along the way. The company has built its own scraping tech to add products to its search results. It shows results from Target, Pottery Barn and other places on the web. The company hasn’t added searches from Amazon yet because it feels there are a lot of “junk” listings on the site and it will take some work to clean up that data. |
21622 | Deft is building e-commerce search to help you find the right product quickly
The company is working on highlighting the image search feature better.
The company said that it doesn’t just look at the listing and description for search results. It also looks at materials, reviews, photos and more. This way, when someone searches for a “pet-friendly” couch, Deft can return results with stain and scratch-resistant material.
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars.” Zach Hudson
Deft is currently focusing on furniture and home décor search but aims to expand to different categories along the way. The company has built its own scraping tech to add products to its search results. It shows results from Target, Pottery Barn and other places on the web. The company hasn’t added searches from Amazon yet because it feels there are a lot of “junk” listings on the site and it will take some work to clean up that data.
Hudson told TechCrunch that there are a few plaguing problems with the traditional search experience that prevent users from finding a suitable item. |
21623 | Deft is building e-commerce search to help you find the right product quickly
It also looks at materials, reviews, photos and more. This way, when someone searches for a “pet-friendly” couch, Deft can return results with stain and scratch-resistant material.
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars.” Zach Hudson
Deft is currently focusing on furniture and home décor search but aims to expand to different categories along the way. The company has built its own scraping tech to add products to its search results. It shows results from Target, Pottery Barn and other places on the web. The company hasn’t added searches from Amazon yet because it feels there are a lot of “junk” listings on the site and it will take some work to clean up that data.
Hudson told TechCrunch that there are a few plaguing problems with the traditional search experience that prevent users from finding a suitable item.
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars. |
21624 | Deft is building e-commerce search to help you find the right product quickly
This way, when someone searches for a “pet-friendly” couch, Deft can return results with stain and scratch-resistant material.
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars.” Zach Hudson
Deft is currently focusing on furniture and home décor search but aims to expand to different categories along the way. The company has built its own scraping tech to add products to its search results. It shows results from Target, Pottery Barn and other places on the web. The company hasn’t added searches from Amazon yet because it feels there are a lot of “junk” listings on the site and it will take some work to clean up that data.
Hudson told TechCrunch that there are a few plaguing problems with the traditional search experience that prevent users from finding a suitable item.
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars. Some easy searches are now hard because marketers have learned how to game these search engines. |
21625 | Deft is building e-commerce search to help you find the right product quickly
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars.” Zach Hudson
Deft is currently focusing on furniture and home décor search but aims to expand to different categories along the way. The company has built its own scraping tech to add products to its search results. It shows results from Target, Pottery Barn and other places on the web. The company hasn’t added searches from Amazon yet because it feels there are a lot of “junk” listings on the site and it will take some work to clean up that data.
Hudson told TechCrunch that there are a few plaguing problems with the traditional search experience that prevent users from finding a suitable item.
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars. Some easy searches are now hard because marketers have learned how to game these search engines. Plus, now you have AI content that is putting the burden on users to separate fact from fiction,” he said. |
21626 | Deft is building e-commerce search to help you find the right product quickly
The company has built its own scraping tech to add products to its search results. It shows results from Target, Pottery Barn and other places on the web. The company hasn’t added searches from Amazon yet because it feels there are a lot of “junk” listings on the site and it will take some work to clean up that data.
Hudson told TechCrunch that there are a few plaguing problems with the traditional search experience that prevent users from finding a suitable item.
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars. Some easy searches are now hard because marketers have learned how to game these search engines. Plus, now you have AI content that is putting the burden on users to separate fact from fiction,” he said.
The company raised $1.8 million in a seed round from Hustle Fund, Frontier VC, Vitalize, Long Ecommerce Ventures, 43 Ventures and angel investors. |
21627 | Deft is building e-commerce search to help you find the right product quickly
The company has built its own scraping tech to add products to its search results. It shows results from Target, Pottery Barn and other places on the web. The company hasn’t added searches from Amazon yet because it feels there are a lot of “junk” listings on the site and it will take some work to clean up that data.
Hudson told TechCrunch that there are a few plaguing problems with the traditional search experience that prevent users from finding a suitable item.
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars. Some easy searches are now hard because marketers have learned how to game these search engines. Plus, now you have AI content that is putting the burden on users to separate fact from fiction,” he said.
The company raised $1.8 million in a seed round from Hustle Fund, Frontier VC, Vitalize, Long Ecommerce Ventures, 43 Ventures and angel investors.
The startup said it is on track to hit 50,000 monthly active users by the end of this year. |
21628 | Deft is building e-commerce search to help you find the right product quickly
The company hasn’t added searches from Amazon yet because it feels there are a lot of “junk” listings on the site and it will take some work to clean up that data.
Hudson told TechCrunch that there are a few plaguing problems with the traditional search experience that prevent users from finding a suitable item.
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars. Some easy searches are now hard because marketers have learned how to game these search engines. Plus, now you have AI content that is putting the burden on users to separate fact from fiction,” he said.
The company raised $1.8 million in a seed round from Hustle Fund, Frontier VC, Vitalize, Long Ecommerce Ventures, 43 Ventures and angel investors.
The startup said it is on track to hit 50,000 monthly active users by the end of this year. While co-founders didn’t reveal the exact search volume the product is catering to, they said Deft is seeing “tens of thousands” of searches every week. |
21629 | Deft is building e-commerce search to help you find the right product quickly
Hudson told TechCrunch that there are a few plaguing problems with the traditional search experience that prevent users from finding a suitable item.
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars. Some easy searches are now hard because marketers have learned how to game these search engines. Plus, now you have AI content that is putting the burden on users to separate fact from fiction,” he said.
The company raised $1.8 million in a seed round from Hustle Fund, Frontier VC, Vitalize, Long Ecommerce Ventures, 43 Ventures and angel investors.
The startup said it is on track to hit 50,000 monthly active users by the end of this year. While co-founders didn’t reveal the exact search volume the product is catering to, they said Deft is seeing “tens of thousands” of searches every week. They added that people using Deft for the second time do more searches than their first visit. |
21630 | Deft is building e-commerce search to help you find the right product quickly
“You have companies like Google and Amazon that continue to push the most relevant listings down so they can make more advertising dollars. Some easy searches are now hard because marketers have learned how to game these search engines. Plus, now you have AI content that is putting the burden on users to separate fact from fiction,” he said.
The company raised $1.8 million in a seed round from Hustle Fund, Frontier VC, Vitalize, Long Ecommerce Ventures, 43 Ventures and angel investors.
The startup said it is on track to hit 50,000 monthly active users by the end of this year. While co-founders didn’t reveal the exact search volume the product is catering to, they said Deft is seeing “tens of thousands” of searches every week. They added that people using Deft for the second time do more searches than their first visit.
The team also noted that it has a conversion rate that is five times higher — a measure of people buying the product versus seeing it — compared to the standard e-commerce rate, which is around 2-3%, according to various estimates. |
21631 | Deft is building e-commerce search to help you find the right product quickly
Plus, now you have AI content that is putting the burden on users to separate fact from fiction,” he said.
The company raised $1.8 million in a seed round from Hustle Fund, Frontier VC, Vitalize, Long Ecommerce Ventures, 43 Ventures and angel investors.
The startup said it is on track to hit 50,000 monthly active users by the end of this year. While co-founders didn’t reveal the exact search volume the product is catering to, they said Deft is seeing “tens of thousands” of searches every week. They added that people using Deft for the second time do more searches than their first visit.
The team also noted that it has a conversion rate that is five times higher — a measure of people buying the product versus seeing it — compared to the standard e-commerce rate, which is around 2-3%, according to various estimates.
Deft doesn’t show ads on its platform. Rather, it relies on affiliate commissions to generate revenue. |
21632 | Deft is building e-commerce search to help you find the right product quickly
The company raised $1.8 million in a seed round from Hustle Fund, Frontier VC, Vitalize, Long Ecommerce Ventures, 43 Ventures and angel investors.
The startup said it is on track to hit 50,000 monthly active users by the end of this year. While co-founders didn’t reveal the exact search volume the product is catering to, they said Deft is seeing “tens of thousands” of searches every week. They added that people using Deft for the second time do more searches than their first visit.
The team also noted that it has a conversion rate that is five times higher — a measure of people buying the product versus seeing it — compared to the standard e-commerce rate, which is around 2-3%, according to various estimates.
Deft doesn’t show ads on its platform. Rather, it relies on affiliate commissions to generate revenue. However, the startup wants subscriptions to be its primary revenue driver. |
21633 | Deft is building e-commerce search to help you find the right product quickly
The company raised $1.8 million in a seed round from Hustle Fund, Frontier VC, Vitalize, Long Ecommerce Ventures, 43 Ventures and angel investors.
The startup said it is on track to hit 50,000 monthly active users by the end of this year. While co-founders didn’t reveal the exact search volume the product is catering to, they said Deft is seeing “tens of thousands” of searches every week. They added that people using Deft for the second time do more searches than their first visit.
The team also noted that it has a conversion rate that is five times higher — a measure of people buying the product versus seeing it — compared to the standard e-commerce rate, which is around 2-3%, according to various estimates.
Deft doesn’t show ads on its platform. Rather, it relies on affiliate commissions to generate revenue. However, the startup wants subscriptions to be its primary revenue driver. Deft is currently testing two paid tiers: a $10 a month plan, which will offer better search customization to filter out some brands, and a $20 per month plan, which will enable personal shopping service, that will continue to look for suitable products even after you stop searching manually. |
21634 | Deft is building e-commerce search to help you find the right product quickly
While co-founders didn’t reveal the exact search volume the product is catering to, they said Deft is seeing “tens of thousands” of searches every week. They added that people using Deft for the second time do more searches than their first visit.
The team also noted that it has a conversion rate that is five times higher — a measure of people buying the product versus seeing it — compared to the standard e-commerce rate, which is around 2-3%, according to various estimates.
Deft doesn’t show ads on its platform. Rather, it relies on affiliate commissions to generate revenue. However, the startup wants subscriptions to be its primary revenue driver. Deft is currently testing two paid tiers: a $10 a month plan, which will offer better search customization to filter out some brands, and a $20 per month plan, which will enable personal shopping service, that will continue to look for suitable products even after you stop searching manually.
Up next, Deft aims to release a browser extension that helps users search for products by the end of this year or early next year. |
21635 | Deft is building e-commerce search to help you find the right product quickly
They added that people using Deft for the second time do more searches than their first visit.
The team also noted that it has a conversion rate that is five times higher — a measure of people buying the product versus seeing it — compared to the standard e-commerce rate, which is around 2-3%, according to various estimates.
Deft doesn’t show ads on its platform. Rather, it relies on affiliate commissions to generate revenue. However, the startup wants subscriptions to be its primary revenue driver. Deft is currently testing two paid tiers: a $10 a month plan, which will offer better search customization to filter out some brands, and a $20 per month plan, which will enable personal shopping service, that will continue to look for suitable products even after you stop searching manually.
Up next, Deft aims to release a browser extension that helps users search for products by the end of this year or early next year. In the next three years, the company wants to build and release search APIs that other e-commerce sites could use. |
21636 | Deft is building e-commerce search to help you find the right product quickly
The team also noted that it has a conversion rate that is five times higher — a measure of people buying the product versus seeing it — compared to the standard e-commerce rate, which is around 2-3%, according to various estimates.
Deft doesn’t show ads on its platform. Rather, it relies on affiliate commissions to generate revenue. However, the startup wants subscriptions to be its primary revenue driver. Deft is currently testing two paid tiers: a $10 a month plan, which will offer better search customization to filter out some brands, and a $20 per month plan, which will enable personal shopping service, that will continue to look for suitable products even after you stop searching manually.
Up next, Deft aims to release a browser extension that helps users search for products by the end of this year or early next year. In the next three years, the company wants to build and release search APIs that other e-commerce sites could use.
Challenges of building a search startup
Given that it’s building a search solution for e-commerce, Deft already faces challenges from Amazon and Google. |
21637 | Deft is building e-commerce search to help you find the right product quickly
Deft doesn’t show ads on its platform. Rather, it relies on affiliate commissions to generate revenue. However, the startup wants subscriptions to be its primary revenue driver. Deft is currently testing two paid tiers: a $10 a month plan, which will offer better search customization to filter out some brands, and a $20 per month plan, which will enable personal shopping service, that will continue to look for suitable products even after you stop searching manually.
Up next, Deft aims to release a browser extension that helps users search for products by the end of this year or early next year. In the next three years, the company wants to build and release search APIs that other e-commerce sites could use.
Challenges of building a search startup
Given that it’s building a search solution for e-commerce, Deft already faces challenges from Amazon and Google. In September, Amazon updated its visual search feature that lets users snap a photo of a product and search for similar items on the platform. |
21638 | Deft is building e-commerce search to help you find the right product quickly
Rather, it relies on affiliate commissions to generate revenue. However, the startup wants subscriptions to be its primary revenue driver. Deft is currently testing two paid tiers: a $10 a month plan, which will offer better search customization to filter out some brands, and a $20 per month plan, which will enable personal shopping service, that will continue to look for suitable products even after you stop searching manually.
Up next, Deft aims to release a browser extension that helps users search for products by the end of this year or early next year. In the next three years, the company wants to build and release search APIs that other e-commerce sites could use.
Challenges of building a search startup
Given that it’s building a search solution for e-commerce, Deft already faces challenges from Amazon and Google. In September, Amazon updated its visual search feature that lets users snap a photo of a product and search for similar items on the platform. Google released its multi-search feature last year that lets users fuse images and text. |
21639 | Deft is building e-commerce search to help you find the right product quickly
However, the startup wants subscriptions to be its primary revenue driver. Deft is currently testing two paid tiers: a $10 a month plan, which will offer better search customization to filter out some brands, and a $20 per month plan, which will enable personal shopping service, that will continue to look for suitable products even after you stop searching manually.
Up next, Deft aims to release a browser extension that helps users search for products by the end of this year or early next year. In the next three years, the company wants to build and release search APIs that other e-commerce sites could use.
Challenges of building a search startup
Given that it’s building a search solution for e-commerce, Deft already faces challenges from Amazon and Google. In September, Amazon updated its visual search feature that lets users snap a photo of a product and search for similar items on the platform. Google released its multi-search feature last year that lets users fuse images and text. Separately, Deft will also face competition from other startups like Objective, a Matrix Partners-backed startup building an API platform for multimodal search. |
21640 | Deft is building e-commerce search to help you find the right product quickly
Up next, Deft aims to release a browser extension that helps users search for products by the end of this year or early next year. In the next three years, the company wants to build and release search APIs that other e-commerce sites could use.
Challenges of building a search startup
Given that it’s building a search solution for e-commerce, Deft already faces challenges from Amazon and Google. In September, Amazon updated its visual search feature that lets users snap a photo of a product and search for similar items on the platform. Google released its multi-search feature last year that lets users fuse images and text. Separately, Deft will also face competition from other startups like Objective, a Matrix Partners-backed startup building an API platform for multimodal search.
Caroline Casson, a partner at Vitalize Venture Capital and an investor in Deft, believes the startup has an edge because of its knowledge graph for products.
“Building a robust e-commerce search engine is incredibly complex on the backend. |
21641 | Deft is building e-commerce search to help you find the right product quickly
In the next three years, the company wants to build and release search APIs that other e-commerce sites could use.
Challenges of building a search startup
Given that it’s building a search solution for e-commerce, Deft already faces challenges from Amazon and Google. In September, Amazon updated its visual search feature that lets users snap a photo of a product and search for similar items on the platform. Google released its multi-search feature last year that lets users fuse images and text. Separately, Deft will also face competition from other startups like Objective, a Matrix Partners-backed startup building an API platform for multimodal search.
Caroline Casson, a partner at Vitalize Venture Capital and an investor in Deft, believes the startup has an edge because of its knowledge graph for products.
“Building a robust e-commerce search engine is incredibly complex on the backend. The extensive knowledge graph that Deft has built combined with AI search capabilities makes for a high-quality user experience. |
21642 | Deft is building e-commerce search to help you find the right product quickly
In the next three years, the company wants to build and release search APIs that other e-commerce sites could use.
Challenges of building a search startup
Given that it’s building a search solution for e-commerce, Deft already faces challenges from Amazon and Google. In September, Amazon updated its visual search feature that lets users snap a photo of a product and search for similar items on the platform. Google released its multi-search feature last year that lets users fuse images and text. Separately, Deft will also face competition from other startups like Objective, a Matrix Partners-backed startup building an API platform for multimodal search.
Caroline Casson, a partner at Vitalize Venture Capital and an investor in Deft, believes the startup has an edge because of its knowledge graph for products.
“Building a robust e-commerce search engine is incredibly complex on the backend. The extensive knowledge graph that Deft has built combined with AI search capabilities makes for a high-quality user experience. We were excited about early iterations of the product when we invested and we continue to be impressed with each product enhancement,” Casson told TechCrunch over email. |
21643 | Deft is building e-commerce search to help you find the right product quickly
In September, Amazon updated its visual search feature that lets users snap a photo of a product and search for similar items on the platform. Google released its multi-search feature last year that lets users fuse images and text. Separately, Deft will also face competition from other startups like Objective, a Matrix Partners-backed startup building an API platform for multimodal search.
Caroline Casson, a partner at Vitalize Venture Capital and an investor in Deft, believes the startup has an edge because of its knowledge graph for products.
“Building a robust e-commerce search engine is incredibly complex on the backend. The extensive knowledge graph that Deft has built combined with AI search capabilities makes for a high-quality user experience. We were excited about early iterations of the product when we invested and we continue to be impressed with each product enhancement,” Casson told TechCrunch over email.
Adii Pienaar, another investor, and co-founder of WooCommerce, which was acquired by Automattic, told TechCrunch over a call that he sees Deft as solving user experience problems. |
21644 | Deft is building e-commerce search to help you find the right product quickly
Google released its multi-search feature last year that lets users fuse images and text. Separately, Deft will also face competition from other startups like Objective, a Matrix Partners-backed startup building an API platform for multimodal search.
Caroline Casson, a partner at Vitalize Venture Capital and an investor in Deft, believes the startup has an edge because of its knowledge graph for products.
“Building a robust e-commerce search engine is incredibly complex on the backend. The extensive knowledge graph that Deft has built combined with AI search capabilities makes for a high-quality user experience. We were excited about early iterations of the product when we invested and we continue to be impressed with each product enhancement,” Casson told TechCrunch over email.
Adii Pienaar, another investor, and co-founder of WooCommerce, which was acquired by Automattic, told TechCrunch over a call that he sees Deft as solving user experience problems.
“Over the last couple of years, consumers have been trying out new ways to interact with and purchase products. |
21645 | Deft is building e-commerce search to help you find the right product quickly
Separately, Deft will also face competition from other startups like Objective, a Matrix Partners-backed startup building an API platform for multimodal search.
Caroline Casson, a partner at Vitalize Venture Capital and an investor in Deft, believes the startup has an edge because of its knowledge graph for products.
“Building a robust e-commerce search engine is incredibly complex on the backend. The extensive knowledge graph that Deft has built combined with AI search capabilities makes for a high-quality user experience. We were excited about early iterations of the product when we invested and we continue to be impressed with each product enhancement,” Casson told TechCrunch over email.
Adii Pienaar, another investor, and co-founder of WooCommerce, which was acquired by Automattic, told TechCrunch over a call that he sees Deft as solving user experience problems.
“Over the last couple of years, consumers have been trying out new ways to interact with and purchase products. I see Deft as creating a new kind of UX for purchasing,” he said. |
21646 | Deft is building e-commerce search to help you find the right product quickly
Caroline Casson, a partner at Vitalize Venture Capital and an investor in Deft, believes the startup has an edge because of its knowledge graph for products.
“Building a robust e-commerce search engine is incredibly complex on the backend. The extensive knowledge graph that Deft has built combined with AI search capabilities makes for a high-quality user experience. We were excited about early iterations of the product when we invested and we continue to be impressed with each product enhancement,” Casson told TechCrunch over email.
Adii Pienaar, another investor, and co-founder of WooCommerce, which was acquired by Automattic, told TechCrunch over a call that he sees Deft as solving user experience problems.
“Over the last couple of years, consumers have been trying out new ways to interact with and purchase products. I see Deft as creating a new kind of UX for purchasing,” he said.
Startups like Neeva — which was founded by former Google execs — tried to convince people to switch to paid and private search with additional features. |
21647 | Deft is building e-commerce search to help you find the right product quickly
“Building a robust e-commerce search engine is incredibly complex on the backend. The extensive knowledge graph that Deft has built combined with AI search capabilities makes for a high-quality user experience. We were excited about early iterations of the product when we invested and we continue to be impressed with each product enhancement,” Casson told TechCrunch over email.
Adii Pienaar, another investor, and co-founder of WooCommerce, which was acquired by Automattic, told TechCrunch over a call that he sees Deft as solving user experience problems.
“Over the last couple of years, consumers have been trying out new ways to interact with and purchase products. I see Deft as creating a new kind of UX for purchasing,” he said.
Startups like Neeva — which was founded by former Google execs — tried to convince people to switch to paid and private search with additional features. However, earlier this year, the startup shut down its consumer efforts and eventually got acquired by Snowflake. |
21648 | Deft is building e-commerce search to help you find the right product quickly
The extensive knowledge graph that Deft has built combined with AI search capabilities makes for a high-quality user experience. We were excited about early iterations of the product when we invested and we continue to be impressed with each product enhancement,” Casson told TechCrunch over email.
Adii Pienaar, another investor, and co-founder of WooCommerce, which was acquired by Automattic, told TechCrunch over a call that he sees Deft as solving user experience problems.
“Over the last couple of years, consumers have been trying out new ways to interact with and purchase products. I see Deft as creating a new kind of UX for purchasing,” he said.
Startups like Neeva — which was founded by former Google execs — tried to convince people to switch to paid and private search with additional features. However, earlier this year, the startup shut down its consumer efforts and eventually got acquired by Snowflake.
Pienaar said that Deft has to give compelling reasons to users to switch to its service. |
21649 | Deft is building e-commerce search to help you find the right product quickly
We were excited about early iterations of the product when we invested and we continue to be impressed with each product enhancement,” Casson told TechCrunch over email.
Adii Pienaar, another investor, and co-founder of WooCommerce, which was acquired by Automattic, told TechCrunch over a call that he sees Deft as solving user experience problems.
“Over the last couple of years, consumers have been trying out new ways to interact with and purchase products. I see Deft as creating a new kind of UX for purchasing,” he said.
Startups like Neeva — which was founded by former Google execs — tried to convince people to switch to paid and private search with additional features. However, earlier this year, the startup shut down its consumer efforts and eventually got acquired by Snowflake.
Pienaar said that Deft has to give compelling reasons to users to switch to its service.
“Users’ natural behavior for search is to follow the path of least resistance, i.e. |
21650 | Deft is building e-commerce search to help you find the right product quickly
Adii Pienaar, another investor, and co-founder of WooCommerce, which was acquired by Automattic, told TechCrunch over a call that he sees Deft as solving user experience problems.
“Over the last couple of years, consumers have been trying out new ways to interact with and purchase products. I see Deft as creating a new kind of UX for purchasing,” he said.
Startups like Neeva — which was founded by former Google execs — tried to convince people to switch to paid and private search with additional features. However, earlier this year, the startup shut down its consumer efforts and eventually got acquired by Snowflake.
Pienaar said that Deft has to give compelling reasons to users to switch to its service.
“Users’ natural behavior for search is to follow the path of least resistance, i.e. most people just pick up their phone and just use the default search engine. For Deft to change that behavior, they will need to create a high-value proposition,” he said. |
21651 | Deft is building e-commerce search to help you find the right product quickly
“Over the last couple of years, consumers have been trying out new ways to interact with and purchase products. I see Deft as creating a new kind of UX for purchasing,” he said.
Startups like Neeva — which was founded by former Google execs — tried to convince people to switch to paid and private search with additional features. However, earlier this year, the startup shut down its consumer efforts and eventually got acquired by Snowflake.
Pienaar said that Deft has to give compelling reasons to users to switch to its service.
“Users’ natural behavior for search is to follow the path of least resistance, i.e. most people just pick up their phone and just use the default search engine. For Deft to change that behavior, they will need to create a high-value proposition,” he said.
Amir Konigsberg, an investor and founder of e-commerce search startup Twiggle (which shut down), said his startup wanted to solve ChatGPT-type interactions in the shopping world. |
21652 | Deft is building e-commerce search to help you find the right product quickly
I see Deft as creating a new kind of UX for purchasing,” he said.
Startups like Neeva — which was founded by former Google execs — tried to convince people to switch to paid and private search with additional features. However, earlier this year, the startup shut down its consumer efforts and eventually got acquired by Snowflake.
Pienaar said that Deft has to give compelling reasons to users to switch to its service.
“Users’ natural behavior for search is to follow the path of least resistance, i.e. most people just pick up their phone and just use the default search engine. For Deft to change that behavior, they will need to create a high-value proposition,” he said.
Amir Konigsberg, an investor and founder of e-commerce search startup Twiggle (which shut down), said his startup wanted to solve ChatGPT-type interactions in the shopping world. He said that the main problem for startups in this space is the go-to-market strategy and fundraising. |
21653 | Deft is building e-commerce search to help you find the right product quickly
Startups like Neeva — which was founded by former Google execs — tried to convince people to switch to paid and private search with additional features. However, earlier this year, the startup shut down its consumer efforts and eventually got acquired by Snowflake.
Pienaar said that Deft has to give compelling reasons to users to switch to its service.
“Users’ natural behavior for search is to follow the path of least resistance, i.e. most people just pick up their phone and just use the default search engine. For Deft to change that behavior, they will need to create a high-value proposition,” he said.
Amir Konigsberg, an investor and founder of e-commerce search startup Twiggle (which shut down), said his startup wanted to solve ChatGPT-type interactions in the shopping world. He said that the main problem for startups in this space is the go-to-market strategy and fundraising.
“The problem with competing with e-commerce players is not just about user experience, it’s also about logistics infrastructure and supply chain. |
21654 | Deft is building e-commerce search to help you find the right product quickly
However, earlier this year, the startup shut down its consumer efforts and eventually got acquired by Snowflake.
Pienaar said that Deft has to give compelling reasons to users to switch to its service.
“Users’ natural behavior for search is to follow the path of least resistance, i.e. most people just pick up their phone and just use the default search engine. For Deft to change that behavior, they will need to create a high-value proposition,” he said.
Amir Konigsberg, an investor and founder of e-commerce search startup Twiggle (which shut down), said his startup wanted to solve ChatGPT-type interactions in the shopping world. He said that the main problem for startups in this space is the go-to-market strategy and fundraising.
“The problem with competing with e-commerce players is not just about user experience, it’s also about logistics infrastructure and supply chain. So a startup catering to consumer search has to invest a lot of money into making it a viable business,” Konigsberg told TechCrunch. |
21655 | Deft is building e-commerce search to help you find the right product quickly
Pienaar said that Deft has to give compelling reasons to users to switch to its service.
“Users’ natural behavior for search is to follow the path of least resistance, i.e. most people just pick up their phone and just use the default search engine. For Deft to change that behavior, they will need to create a high-value proposition,” he said.
Amir Konigsberg, an investor and founder of e-commerce search startup Twiggle (which shut down), said his startup wanted to solve ChatGPT-type interactions in the shopping world. He said that the main problem for startups in this space is the go-to-market strategy and fundraising.
“The problem with competing with e-commerce players is not just about user experience, it’s also about logistics infrastructure and supply chain. So a startup catering to consumer search has to invest a lot of money into making it a viable business,” Konigsberg told TechCrunch.
He also added that it will be difficult for a startup like Deft to build user loyalty while competing against Google and Amazon. |
21656 | Deft is building e-commerce search to help you find the right product quickly
“Users’ natural behavior for search is to follow the path of least resistance, i.e. most people just pick up their phone and just use the default search engine. For Deft to change that behavior, they will need to create a high-value proposition,” he said.
Amir Konigsberg, an investor and founder of e-commerce search startup Twiggle (which shut down), said his startup wanted to solve ChatGPT-type interactions in the shopping world. He said that the main problem for startups in this space is the go-to-market strategy and fundraising.
“The problem with competing with e-commerce players is not just about user experience, it’s also about logistics infrastructure and supply chain. So a startup catering to consumer search has to invest a lot of money into making it a viable business,” Konigsberg told TechCrunch.
He also added that it will be difficult for a startup like Deft to build user loyalty while competing against Google and Amazon.
Both Pienaar and Konigsberg said that Deft will have to involve retailers in the mix either as partners or as customers of their search product. |
21657 | Deft is building e-commerce search to help you find the right product quickly
For Deft to change that behavior, they will need to create a high-value proposition,” he said.
Amir Konigsberg, an investor and founder of e-commerce search startup Twiggle (which shut down), said his startup wanted to solve ChatGPT-type interactions in the shopping world. He said that the main problem for startups in this space is the go-to-market strategy and fundraising.
“The problem with competing with e-commerce players is not just about user experience, it’s also about logistics infrastructure and supply chain. So a startup catering to consumer search has to invest a lot of money into making it a viable business,” Konigsberg told TechCrunch.
He also added that it will be difficult for a startup like Deft to build user loyalty while competing against Google and Amazon.
Both Pienaar and Konigsberg said that Deft will have to involve retailers in the mix either as partners or as customers of their search product. Either way, it’s going to be interesting to see if Deft can build a user base on its own or sell its search feature to e-commerce retailers. |
21658 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
How Do Intestinal Stem Cells Know Their Destiny? What Triggers Stem Cells to Repair Our Intestines? New Research Offers Answers
What Tells Intestinal Stem Cells to Regenerate? New Study Explains
Stem cells have the remarkable ability to transform and replenish dying or injured cells. Yet, the process by which they select their cellular identity in particular scenarios remains a puzzle.
The research team led by Bon-Kyoung Koo at IMBA, in collaboration with the Institute for Basic Science, has pinpointed a previously unknown gene, Daam1. This gene is critical for activating the formation of secretory cells in the intestines.
This breakthrough, documented in the November 24 issue of Science Advances, heralds a new chapter in the understanding of cancer.
Much like automobiles that require constant maintenance to remain operational, our bodies rely on the continual renewal of cells to sustain organ function. |
21659 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
How Do Intestinal Stem Cells Know Their Destiny? What Triggers Stem Cells to Repair Our Intestines? New Research Offers Answers
What Tells Intestinal Stem Cells to Regenerate? New Study Explains
Stem cells have the remarkable ability to transform and replenish dying or injured cells. Yet, the process by which they select their cellular identity in particular scenarios remains a puzzle.
The research team led by Bon-Kyoung Koo at IMBA, in collaboration with the Institute for Basic Science, has pinpointed a previously unknown gene, Daam1. This gene is critical for activating the formation of secretory cells in the intestines.
This breakthrough, documented in the November 24 issue of Science Advances, heralds a new chapter in the understanding of cancer.
Much like automobiles that require constant maintenance to remain operational, our bodies rely on the continual renewal of cells to sustain organ function. Such regeneration is made possible by adult stem cells native to the tissues, which, unlike their embryonic counterparts that can become any cell type, are programmed to only replace the specific types of cells in their respective tissues. |
21660 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
New Study Explains
Stem cells have the remarkable ability to transform and replenish dying or injured cells. Yet, the process by which they select their cellular identity in particular scenarios remains a puzzle.
The research team led by Bon-Kyoung Koo at IMBA, in collaboration with the Institute for Basic Science, has pinpointed a previously unknown gene, Daam1. This gene is critical for activating the formation of secretory cells in the intestines.
This breakthrough, documented in the November 24 issue of Science Advances, heralds a new chapter in the understanding of cancer.
Much like automobiles that require constant maintenance to remain operational, our bodies rely on the continual renewal of cells to sustain organ function. Such regeneration is made possible by adult stem cells native to the tissues, which, unlike their embryonic counterparts that can become any cell type, are programmed to only replace the specific types of cells in their respective tissues.
Determining how these cells are guided to develop into specific tissue cells has been a key question. |
21661 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
Yet, the process by which they select their cellular identity in particular scenarios remains a puzzle.
The research team led by Bon-Kyoung Koo at IMBA, in collaboration with the Institute for Basic Science, has pinpointed a previously unknown gene, Daam1. This gene is critical for activating the formation of secretory cells in the intestines.
This breakthrough, documented in the November 24 issue of Science Advances, heralds a new chapter in the understanding of cancer.
Much like automobiles that require constant maintenance to remain operational, our bodies rely on the continual renewal of cells to sustain organ function. Such regeneration is made possible by adult stem cells native to the tissues, which, unlike their embryonic counterparts that can become any cell type, are programmed to only replace the specific types of cells in their respective tissues.
Determining how these cells are guided to develop into specific tissue cells has been a key question. Gabriele Colozza, a postdoctoral researcher with Bon-Kyoung Koo at IMBA—currently directing at the Center for Genome Engineering at the Institute for Basic Science in South Korea—took on this challenge by delving into the mechanisms that direct intestinal stem cells. |
21662 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
This gene is critical for activating the formation of secretory cells in the intestines.
This breakthrough, documented in the November 24 issue of Science Advances, heralds a new chapter in the understanding of cancer.
Much like automobiles that require constant maintenance to remain operational, our bodies rely on the continual renewal of cells to sustain organ function. Such regeneration is made possible by adult stem cells native to the tissues, which, unlike their embryonic counterparts that can become any cell type, are programmed to only replace the specific types of cells in their respective tissues.
Determining how these cells are guided to develop into specific tissue cells has been a key question. Gabriele Colozza, a postdoctoral researcher with Bon-Kyoung Koo at IMBA—currently directing at the Center for Genome Engineering at the Institute for Basic Science in South Korea—took on this challenge by delving into the mechanisms that direct intestinal stem cells.
Intestinal stem cells
“In our intestines, cells are exposed to extreme conditions,” comments Colozza. |
21663 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
This breakthrough, documented in the November 24 issue of Science Advances, heralds a new chapter in the understanding of cancer.
Much like automobiles that require constant maintenance to remain operational, our bodies rely on the continual renewal of cells to sustain organ function. Such regeneration is made possible by adult stem cells native to the tissues, which, unlike their embryonic counterparts that can become any cell type, are programmed to only replace the specific types of cells in their respective tissues.
Determining how these cells are guided to develop into specific tissue cells has been a key question. Gabriele Colozza, a postdoctoral researcher with Bon-Kyoung Koo at IMBA—currently directing at the Center for Genome Engineering at the Institute for Basic Science in South Korea—took on this challenge by delving into the mechanisms that direct intestinal stem cells.
Intestinal stem cells
“In our intestines, cells are exposed to extreme conditions,” comments Colozza.
Here, cells face harsh conditions due to factors like mechanical stress, digestive enzymes, and fluctuating pH levels. |
21664 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
Much like automobiles that require constant maintenance to remain operational, our bodies rely on the continual renewal of cells to sustain organ function. Such regeneration is made possible by adult stem cells native to the tissues, which, unlike their embryonic counterparts that can become any cell type, are programmed to only replace the specific types of cells in their respective tissues.
Determining how these cells are guided to develop into specific tissue cells has been a key question. Gabriele Colozza, a postdoctoral researcher with Bon-Kyoung Koo at IMBA—currently directing at the Center for Genome Engineering at the Institute for Basic Science in South Korea—took on this challenge by delving into the mechanisms that direct intestinal stem cells.
Intestinal stem cells
“In our intestines, cells are exposed to extreme conditions,” comments Colozza.
Here, cells face harsh conditions due to factors like mechanical stress, digestive enzymes, and fluctuating pH levels. To counteract this, stem cells within the intestinal lining constantly evolve into new cells to replace those that are damaged. |
21665 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
Such regeneration is made possible by adult stem cells native to the tissues, which, unlike their embryonic counterparts that can become any cell type, are programmed to only replace the specific types of cells in their respective tissues.
Determining how these cells are guided to develop into specific tissue cells has been a key question. Gabriele Colozza, a postdoctoral researcher with Bon-Kyoung Koo at IMBA—currently directing at the Center for Genome Engineering at the Institute for Basic Science in South Korea—took on this challenge by delving into the mechanisms that direct intestinal stem cells.
Intestinal stem cells
“In our intestines, cells are exposed to extreme conditions,” comments Colozza.
Here, cells face harsh conditions due to factors like mechanical stress, digestive enzymes, and fluctuating pH levels. To counteract this, stem cells within the intestinal lining constantly evolve into new cells to replace those that are damaged.
“Uncontrolled stem cell proliferation may lead to tumor formation; on the other hand, if too many stem cells differentiate, the tissue will be depleted of stem cells and ultimately unable to self-renew.”
This intricate balance is maintained through a complex network of signaling pathways and regulatory feedback loops that enable intercellular communication. |
21666 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
Gabriele Colozza, a postdoctoral researcher with Bon-Kyoung Koo at IMBA—currently directing at the Center for Genome Engineering at the Institute for Basic Science in South Korea—took on this challenge by delving into the mechanisms that direct intestinal stem cells.
Intestinal stem cells
“In our intestines, cells are exposed to extreme conditions,” comments Colozza.
Here, cells face harsh conditions due to factors like mechanical stress, digestive enzymes, and fluctuating pH levels. To counteract this, stem cells within the intestinal lining constantly evolve into new cells to replace those that are damaged.
“Uncontrolled stem cell proliferation may lead to tumor formation; on the other hand, if too many stem cells differentiate, the tissue will be depleted of stem cells and ultimately unable to self-renew.”
This intricate balance is maintained through a complex network of signaling pathways and regulatory feedback loops that enable intercellular communication. A crucial player in this process is the Wnt signaling pathway, a well-established mechanism in embryonic growth. |
21667 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
Intestinal stem cells
“In our intestines, cells are exposed to extreme conditions,” comments Colozza.
Here, cells face harsh conditions due to factors like mechanical stress, digestive enzymes, and fluctuating pH levels. To counteract this, stem cells within the intestinal lining constantly evolve into new cells to replace those that are damaged.
“Uncontrolled stem cell proliferation may lead to tumor formation; on the other hand, if too many stem cells differentiate, the tissue will be depleted of stem cells and ultimately unable to self-renew.”
This intricate balance is maintained through a complex network of signaling pathways and regulatory feedback loops that enable intercellular communication. A crucial player in this process is the Wnt signaling pathway, a well-established mechanism in embryonic growth.
However, without proper regulation, an overstimulated Wnt pathway may result in abnormal cell proliferation and, consequently, tumor development.
How Is the Fate of Intestinal Stem Cells Determined? |
21668 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
Intestinal stem cells
“In our intestines, cells are exposed to extreme conditions,” comments Colozza.
Here, cells face harsh conditions due to factors like mechanical stress, digestive enzymes, and fluctuating pH levels. To counteract this, stem cells within the intestinal lining constantly evolve into new cells to replace those that are damaged.
“Uncontrolled stem cell proliferation may lead to tumor formation; on the other hand, if too many stem cells differentiate, the tissue will be depleted of stem cells and ultimately unable to self-renew.”
This intricate balance is maintained through a complex network of signaling pathways and regulatory feedback loops that enable intercellular communication. A crucial player in this process is the Wnt signaling pathway, a well-established mechanism in embryonic growth.
However, without proper regulation, an overstimulated Wnt pathway may result in abnormal cell proliferation and, consequently, tumor development.
How Is the Fate of Intestinal Stem Cells Determined?
Rnf43 is a known regulator that tempers the activity of the Wnt signaling pathway, a role initially discovered by Bon-Kyoung Koo. |
21669 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
To counteract this, stem cells within the intestinal lining constantly evolve into new cells to replace those that are damaged.
“Uncontrolled stem cell proliferation may lead to tumor formation; on the other hand, if too many stem cells differentiate, the tissue will be depleted of stem cells and ultimately unable to self-renew.”
This intricate balance is maintained through a complex network of signaling pathways and regulatory feedback loops that enable intercellular communication. A crucial player in this process is the Wnt signaling pathway, a well-established mechanism in embryonic growth.
However, without proper regulation, an overstimulated Wnt pathway may result in abnormal cell proliferation and, consequently, tumor development.
How Is the Fate of Intestinal Stem Cells Determined?
Rnf43 is a known regulator that tempers the activity of the Wnt signaling pathway, a role initially discovered by Bon-Kyoung Koo. Previously, Rnf43 was recognized for its ability to flag the Wnt receptor Frizzled for destruction. |
21670 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
To counteract this, stem cells within the intestinal lining constantly evolve into new cells to replace those that are damaged.
“Uncontrolled stem cell proliferation may lead to tumor formation; on the other hand, if too many stem cells differentiate, the tissue will be depleted of stem cells and ultimately unable to self-renew.”
This intricate balance is maintained through a complex network of signaling pathways and regulatory feedback loops that enable intercellular communication. A crucial player in this process is the Wnt signaling pathway, a well-established mechanism in embryonic growth.
However, without proper regulation, an overstimulated Wnt pathway may result in abnormal cell proliferation and, consequently, tumor development.
How Is the Fate of Intestinal Stem Cells Determined?
Rnf43 is a known regulator that tempers the activity of the Wnt signaling pathway, a role initially discovered by Bon-Kyoung Koo. Previously, Rnf43 was recognized for its ability to flag the Wnt receptor Frizzled for destruction.
“We wanted to know how Rnf43 works, and also what – in turn – controls Rnf43 and helps it to regulate Wnt signalling,” explains the research team. |
21671 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
A crucial player in this process is the Wnt signaling pathway, a well-established mechanism in embryonic growth.
However, without proper regulation, an overstimulated Wnt pathway may result in abnormal cell proliferation and, consequently, tumor development.
How Is the Fate of Intestinal Stem Cells Determined?
Rnf43 is a known regulator that tempers the activity of the Wnt signaling pathway, a role initially discovered by Bon-Kyoung Koo. Previously, Rnf43 was recognized for its ability to flag the Wnt receptor Frizzled for destruction.
“We wanted to know how Rnf43 works, and also what – in turn – controls Rnf43 and helps it to regulate Wnt signalling,” explains the research team.
It was understood from past studies that Rnf43 could not effectively degrade Frizzled by itself, which is embedded in the cell’s plasma membrane. |
21672 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
A crucial player in this process is the Wnt signaling pathway, a well-established mechanism in embryonic growth.
However, without proper regulation, an overstimulated Wnt pathway may result in abnormal cell proliferation and, consequently, tumor development.
How Is the Fate of Intestinal Stem Cells Determined?
Rnf43 is a known regulator that tempers the activity of the Wnt signaling pathway, a role initially discovered by Bon-Kyoung Koo. Previously, Rnf43 was recognized for its ability to flag the Wnt receptor Frizzled for destruction.
“We wanted to know how Rnf43 works, and also what – in turn – controls Rnf43 and helps it to regulate Wnt signalling,” explains the research team.
It was understood from past studies that Rnf43 could not effectively degrade Frizzled by itself, which is embedded in the cell’s plasma membrane.
“In our project, we used biochemical assays to identify which proteins interact with Rnf43.”
They discovered that the protein Daam1 is a crucial collaborator with Rnf43. |
21673 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
However, without proper regulation, an overstimulated Wnt pathway may result in abnormal cell proliferation and, consequently, tumor development.
How Is the Fate of Intestinal Stem Cells Determined?
Rnf43 is a known regulator that tempers the activity of the Wnt signaling pathway, a role initially discovered by Bon-Kyoung Koo. Previously, Rnf43 was recognized for its ability to flag the Wnt receptor Frizzled for destruction.
“We wanted to know how Rnf43 works, and also what – in turn – controls Rnf43 and helps it to regulate Wnt signalling,” explains the research team.
It was understood from past studies that Rnf43 could not effectively degrade Frizzled by itself, which is embedded in the cell’s plasma membrane.
“In our project, we used biochemical assays to identify which proteins interact with Rnf43.”
They discovered that the protein Daam1 is a crucial collaborator with Rnf43.
To probe the influence of Daam1 on Rnf43 and the tissue systems they influence, Colozza utilized intestinal organoids. |
21674 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
How Is the Fate of Intestinal Stem Cells Determined?
Rnf43 is a known regulator that tempers the activity of the Wnt signaling pathway, a role initially discovered by Bon-Kyoung Koo. Previously, Rnf43 was recognized for its ability to flag the Wnt receptor Frizzled for destruction.
“We wanted to know how Rnf43 works, and also what – in turn – controls Rnf43 and helps it to regulate Wnt signalling,” explains the research team.
It was understood from past studies that Rnf43 could not effectively degrade Frizzled by itself, which is embedded in the cell’s plasma membrane.
“In our project, we used biochemical assays to identify which proteins interact with Rnf43.”
They discovered that the protein Daam1 is a crucial collaborator with Rnf43.
To probe the influence of Daam1 on Rnf43 and the tissue systems they influence, Colozza utilized intestinal organoids.
“We found that Daam1 is required for Rnf43 to be active, so for Rnf43 to regulate Wnt signaling at all. |
21675 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
Previously, Rnf43 was recognized for its ability to flag the Wnt receptor Frizzled for destruction.
“We wanted to know how Rnf43 works, and also what – in turn – controls Rnf43 and helps it to regulate Wnt signalling,” explains the research team.
It was understood from past studies that Rnf43 could not effectively degrade Frizzled by itself, which is embedded in the cell’s plasma membrane.
“In our project, we used biochemical assays to identify which proteins interact with Rnf43.”
They discovered that the protein Daam1 is a crucial collaborator with Rnf43.
To probe the influence of Daam1 on Rnf43 and the tissue systems they influence, Colozza utilized intestinal organoids.
“We found that Daam1 is required for Rnf43 to be active, so for Rnf43 to regulate Wnt signaling at all. Further work in cells showed Rnf43 needs Daam1 to move the Wnt receptor Frizzled into vesicles called endosomes. |
21676 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
“We wanted to know how Rnf43 works, and also what – in turn – controls Rnf43 and helps it to regulate Wnt signalling,” explains the research team.
It was understood from past studies that Rnf43 could not effectively degrade Frizzled by itself, which is embedded in the cell’s plasma membrane.
“In our project, we used biochemical assays to identify which proteins interact with Rnf43.”
They discovered that the protein Daam1 is a crucial collaborator with Rnf43.
To probe the influence of Daam1 on Rnf43 and the tissue systems they influence, Colozza utilized intestinal organoids.
“We found that Daam1 is required for Rnf43 to be active, so for Rnf43 to regulate Wnt signaling at all. Further work in cells showed Rnf43 needs Daam1 to move the Wnt receptor Frizzled into vesicles called endosomes. From the endosomes, Frizzled is shuttled to the lysosomes where it is degraded, dampening Wnt signaling,” Colozza elaborates. |
21677 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
It was understood from past studies that Rnf43 could not effectively degrade Frizzled by itself, which is embedded in the cell’s plasma membrane.
“In our project, we used biochemical assays to identify which proteins interact with Rnf43.”
They discovered that the protein Daam1 is a crucial collaborator with Rnf43.
To probe the influence of Daam1 on Rnf43 and the tissue systems they influence, Colozza utilized intestinal organoids.
“We found that Daam1 is required for Rnf43 to be active, so for Rnf43 to regulate Wnt signaling at all. Further work in cells showed Rnf43 needs Daam1 to move the Wnt receptor Frizzled into vesicles called endosomes. From the endosomes, Frizzled is shuttled to the lysosomes where it is degraded, dampening Wnt signaling,” Colozza elaborates.
Intestinal organoids, which are three-dimensional cultures derived from adult stem cells, replicate the environment of the intestinal lining. |
21678 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
“In our project, we used biochemical assays to identify which proteins interact with Rnf43.”
They discovered that the protein Daam1 is a crucial collaborator with Rnf43.
To probe the influence of Daam1 on Rnf43 and the tissue systems they influence, Colozza utilized intestinal organoids.
“We found that Daam1 is required for Rnf43 to be active, so for Rnf43 to regulate Wnt signaling at all. Further work in cells showed Rnf43 needs Daam1 to move the Wnt receptor Frizzled into vesicles called endosomes. From the endosomes, Frizzled is shuttled to the lysosomes where it is degraded, dampening Wnt signaling,” Colozza elaborates.
Intestinal organoids, which are three-dimensional cultures derived from adult stem cells, replicate the environment of the intestinal lining. For Colozza, these organoids were a window into how Rnf43 and Daam1 influence the intricate interplay between the renewal and differentiation of stem cells in the gut. |
21679 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
To probe the influence of Daam1 on Rnf43 and the tissue systems they influence, Colozza utilized intestinal organoids.
“We found that Daam1 is required for Rnf43 to be active, so for Rnf43 to regulate Wnt signaling at all. Further work in cells showed Rnf43 needs Daam1 to move the Wnt receptor Frizzled into vesicles called endosomes. From the endosomes, Frizzled is shuttled to the lysosomes where it is degraded, dampening Wnt signaling,” Colozza elaborates.
Intestinal organoids, which are three-dimensional cultures derived from adult stem cells, replicate the environment of the intestinal lining. For Colozza, these organoids were a window into how Rnf43 and Daam1 influence the intricate interplay between the renewal and differentiation of stem cells in the gut.
“We found that when we knock-out Rnf43 or Daam1, the organoids grow into tumor-like structures. |
21680 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
“We found that Daam1 is required for Rnf43 to be active, so for Rnf43 to regulate Wnt signaling at all. Further work in cells showed Rnf43 needs Daam1 to move the Wnt receptor Frizzled into vesicles called endosomes. From the endosomes, Frizzled is shuttled to the lysosomes where it is degraded, dampening Wnt signaling,” Colozza elaborates.
Intestinal organoids, which are three-dimensional cultures derived from adult stem cells, replicate the environment of the intestinal lining. For Colozza, these organoids were a window into how Rnf43 and Daam1 influence the intricate interplay between the renewal and differentiation of stem cells in the gut.
“We found that when we knock-out Rnf43 or Daam1, the organoids grow into tumor-like structures. These tumor-like organoids keep on growing, even if we withdraw the growth factors they usually depend on, such as R-spondin,” Colozza notes. |
21681 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
Further work in cells showed Rnf43 needs Daam1 to move the Wnt receptor Frizzled into vesicles called endosomes. From the endosomes, Frizzled is shuttled to the lysosomes where it is degraded, dampening Wnt signaling,” Colozza elaborates.
Intestinal organoids, which are three-dimensional cultures derived from adult stem cells, replicate the environment of the intestinal lining. For Colozza, these organoids were a window into how Rnf43 and Daam1 influence the intricate interplay between the renewal and differentiation of stem cells in the gut.
“We found that when we knock-out Rnf43 or Daam1, the organoids grow into tumor-like structures. These tumor-like organoids keep on growing, even if we withdraw the growth factors they usually depend on, such as R-spondin,” Colozza notes.
What Tells Intestinal Stem Cells to Regenerate? |
21682 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
Further work in cells showed Rnf43 needs Daam1 to move the Wnt receptor Frizzled into vesicles called endosomes. From the endosomes, Frizzled is shuttled to the lysosomes where it is degraded, dampening Wnt signaling,” Colozza elaborates.
Intestinal organoids, which are three-dimensional cultures derived from adult stem cells, replicate the environment of the intestinal lining. For Colozza, these organoids were a window into how Rnf43 and Daam1 influence the intricate interplay between the renewal and differentiation of stem cells in the gut.
“We found that when we knock-out Rnf43 or Daam1, the organoids grow into tumor-like structures. These tumor-like organoids keep on growing, even if we withdraw the growth factors they usually depend on, such as R-spondin,” Colozza notes.
What Tells Intestinal Stem Cells to Regenerate? Here’s What a New Study Says
Activating Paneth Cell Development
Upon delving deeper into this research using mouse models, Colozza and team found something unexpected. |
21683 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
From the endosomes, Frizzled is shuttled to the lysosomes where it is degraded, dampening Wnt signaling,” Colozza elaborates.
Intestinal organoids, which are three-dimensional cultures derived from adult stem cells, replicate the environment of the intestinal lining. For Colozza, these organoids were a window into how Rnf43 and Daam1 influence the intricate interplay between the renewal and differentiation of stem cells in the gut.
“We found that when we knock-out Rnf43 or Daam1, the organoids grow into tumor-like structures. These tumor-like organoids keep on growing, even if we withdraw the growth factors they usually depend on, such as R-spondin,” Colozza notes.
What Tells Intestinal Stem Cells to Regenerate? Here’s What a New Study Says
Activating Paneth Cell Development
Upon delving deeper into this research using mouse models, Colozza and team found something unexpected.
“When Rnf43 was missing, the intestines grew tumors – as expected. |
21684 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
Intestinal organoids, which are three-dimensional cultures derived from adult stem cells, replicate the environment of the intestinal lining. For Colozza, these organoids were a window into how Rnf43 and Daam1 influence the intricate interplay between the renewal and differentiation of stem cells in the gut.
“We found that when we knock-out Rnf43 or Daam1, the organoids grow into tumor-like structures. These tumor-like organoids keep on growing, even if we withdraw the growth factors they usually depend on, such as R-spondin,” Colozza notes.
What Tells Intestinal Stem Cells to Regenerate? Here’s What a New Study Says
Activating Paneth Cell Development
Upon delving deeper into this research using mouse models, Colozza and team found something unexpected.
“When Rnf43 was missing, the intestines grew tumors – as expected. But when Daam1 was missing, no tumors grew. |
21685 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
Intestinal organoids, which are three-dimensional cultures derived from adult stem cells, replicate the environment of the intestinal lining. For Colozza, these organoids were a window into how Rnf43 and Daam1 influence the intricate interplay between the renewal and differentiation of stem cells in the gut.
“We found that when we knock-out Rnf43 or Daam1, the organoids grow into tumor-like structures. These tumor-like organoids keep on growing, even if we withdraw the growth factors they usually depend on, such as R-spondin,” Colozza notes.
What Tells Intestinal Stem Cells to Regenerate? Here’s What a New Study Says
Activating Paneth Cell Development
Upon delving deeper into this research using mouse models, Colozza and team found something unexpected.
“When Rnf43 was missing, the intestines grew tumors – as expected. But when Daam1 was missing, no tumors grew. We were puzzled by this striking difference: how can the loss of factors in the same pathway, that behave similarly in organoids, lead to such different outcomes?”
Upon closer inspection of the intestinal samples, the team observed a proliferation of Paneth cells—secretory cells known for producing growth factors like Wnt that prompt cell division—in the intestines without Rnf43. |
21686 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
These tumor-like organoids keep on growing, even if we withdraw the growth factors they usually depend on, such as R-spondin,” Colozza notes.
What Tells Intestinal Stem Cells to Regenerate? Here’s What a New Study Says
Activating Paneth Cell Development
Upon delving deeper into this research using mouse models, Colozza and team found something unexpected.
“When Rnf43 was missing, the intestines grew tumors – as expected. But when Daam1 was missing, no tumors grew. We were puzzled by this striking difference: how can the loss of factors in the same pathway, that behave similarly in organoids, lead to such different outcomes?”
Upon closer inspection of the intestinal samples, the team observed a proliferation of Paneth cells—secretory cells known for producing growth factors like Wnt that prompt cell division—in the intestines without Rnf43. Conversely, intestines deficient in Daam1 showed no such increase in Paneth cells. |
21687 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
What Tells Intestinal Stem Cells to Regenerate? Here’s What a New Study Says
Activating Paneth Cell Development
Upon delving deeper into this research using mouse models, Colozza and team found something unexpected.
“When Rnf43 was missing, the intestines grew tumors – as expected. But when Daam1 was missing, no tumors grew. We were puzzled by this striking difference: how can the loss of factors in the same pathway, that behave similarly in organoids, lead to such different outcomes?”
Upon closer inspection of the intestinal samples, the team observed a proliferation of Paneth cells—secretory cells known for producing growth factors like Wnt that prompt cell division—in the intestines without Rnf43. Conversely, intestines deficient in Daam1 showed no such increase in Paneth cells.
“Daam1 is required for the efficient formation of Paneth cells. When Daam1 is active, stem cells differentiate to form Paneth cells. |
21688 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
Here’s What a New Study Says
Activating Paneth Cell Development
Upon delving deeper into this research using mouse models, Colozza and team found something unexpected.
“When Rnf43 was missing, the intestines grew tumors – as expected. But when Daam1 was missing, no tumors grew. We were puzzled by this striking difference: how can the loss of factors in the same pathway, that behave similarly in organoids, lead to such different outcomes?”
Upon closer inspection of the intestinal samples, the team observed a proliferation of Paneth cells—secretory cells known for producing growth factors like Wnt that prompt cell division—in the intestines without Rnf43. Conversely, intestines deficient in Daam1 showed no such increase in Paneth cells.
“Daam1 is required for the efficient formation of Paneth cells. When Daam1 is active, stem cells differentiate to form Paneth cells. When Daam1 is not active, the stem cells differentiate into another cell type.”
Tumor Growth Influenced by Cellular Environment
This finding helps to explain the contrasting outcomes observed in intestines and organoids. |
21689 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
“When Rnf43 was missing, the intestines grew tumors – as expected. But when Daam1 was missing, no tumors grew. We were puzzled by this striking difference: how can the loss of factors in the same pathway, that behave similarly in organoids, lead to such different outcomes?”
Upon closer inspection of the intestinal samples, the team observed a proliferation of Paneth cells—secretory cells known for producing growth factors like Wnt that prompt cell division—in the intestines without Rnf43. Conversely, intestines deficient in Daam1 showed no such increase in Paneth cells.
“Daam1 is required for the efficient formation of Paneth cells. When Daam1 is active, stem cells differentiate to form Paneth cells. When Daam1 is not active, the stem cells differentiate into another cell type.”
Tumor Growth Influenced by Cellular Environment
This finding helps to explain the contrasting outcomes observed in intestines and organoids.
“In organoid culture, we scientists provide growth factors, so the knockout of both Rnf43 and Daam1 lead to tumor-like organoids. |
21690 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
Conversely, intestines deficient in Daam1 showed no such increase in Paneth cells.
“Daam1 is required for the efficient formation of Paneth cells. When Daam1 is active, stem cells differentiate to form Paneth cells. When Daam1 is not active, the stem cells differentiate into another cell type.”
Tumor Growth Influenced by Cellular Environment
This finding helps to explain the contrasting outcomes observed in intestines and organoids.
“In organoid culture, we scientists provide growth factors, so the knockout of both Rnf43 and Daam1 lead to tumor-like organoids. But in the intestine, there is no little scientist providing growth factors. Instead, Paneth cells provide growth factors, like Wnt, and create the right conditions for stem cells to survive and divide. When Paneth cells are lacking – such as when Daam1 is not active to drive cells into becoming Paneth cells – stem cells will not divide much. |
21691 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
“Daam1 is required for the efficient formation of Paneth cells. When Daam1 is active, stem cells differentiate to form Paneth cells. When Daam1 is not active, the stem cells differentiate into another cell type.”
Tumor Growth Influenced by Cellular Environment
This finding helps to explain the contrasting outcomes observed in intestines and organoids.
“In organoid culture, we scientists provide growth factors, so the knockout of both Rnf43 and Daam1 lead to tumor-like organoids. But in the intestine, there is no little scientist providing growth factors. Instead, Paneth cells provide growth factors, like Wnt, and create the right conditions for stem cells to survive and divide. When Paneth cells are lacking – such as when Daam1 is not active to drive cells into becoming Paneth cells – stem cells will not divide much. But when there are too many Paneth cells – such as in intestines lacking Rnf43 – the excessive growth factors can contribute to the formation of tumors.”
The findings from Colozza and his team mark the first genetic evidence that Daam1, associated with the non-canonical Wnt pathway, plays a critical role in designating Paneth cell fate and the evolution of this key secretory cell type. |
21692 | The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells’ Fate
“In organoid culture, we scientists provide growth factors, so the knockout of both Rnf43 and Daam1 lead to tumor-like organoids. But in the intestine, there is no little scientist providing growth factors. Instead, Paneth cells provide growth factors, like Wnt, and create the right conditions for stem cells to survive and divide. When Paneth cells are lacking – such as when Daam1 is not active to drive cells into becoming Paneth cells – stem cells will not divide much. But when there are too many Paneth cells – such as in intestines lacking Rnf43 – the excessive growth factors can contribute to the formation of tumors.”
The findings from Colozza and his team mark the first genetic evidence that Daam1, associated with the non-canonical Wnt pathway, plays a critical role in designating Paneth cell fate and the evolution of this key secretory cell type.
“We show that tumor cells modify their microenvironment, and influence their supporting environment so that they can grow better.”
Image Credit: iStock |
21693 | Connecticut moms prowl neighborhood as zombies to raise money for breast cancer research
As Halloween looms up ahead, a cohort of Connecticut moms has been rehearsing their dreadful dance moves and creating creepy costumes in preparation for an annual neighborhood performance on October 31 — all to raise money for breast cancer research.
"It’s a bonding experience," Kate Garin, 39, an accountant in Fairfield, Connecticut, told Fox News Digital.
"Many in our group are survivors," she said, "so to be able to connect with women and share stories and have someone to turn to if, God forbid, this happens to you, it’s very touching. It’s incredible how strong these women are and how amazing they are. And we’re having a lot of fun while raising money."
TO RAISE MILLIONS FOR CANCER CHARITIES, ONE CEO WILL TREK ACROSS THE SOUTH POLE: 'A RISK WORTH TAKING'
The Mombies — a group of nurses, doctors, lawyers, accountants and more — meet in secret for several weeks before Halloween. |
21694 | Connecticut moms prowl neighborhood as zombies to raise money for breast cancer research
"It’s a bonding experience," Kate Garin, 39, an accountant in Fairfield, Connecticut, told Fox News Digital.
"Many in our group are survivors," she said, "so to be able to connect with women and share stories and have someone to turn to if, God forbid, this happens to you, it’s very touching. It’s incredible how strong these women are and how amazing they are. And we’re having a lot of fun while raising money."
TO RAISE MILLIONS FOR CANCER CHARITIES, ONE CEO WILL TREK ACROSS THE SOUTH POLE: 'A RISK WORTH TAKING'
The Mombies — a group of nurses, doctors, lawyers, accountants and more — meet in secret for several weeks before Halloween.
They select a theme and music, a mashup that always includes Michael Jackson’s "Thriller." They also work with professional choreographers and finetune their costumes. |
21695 | Connecticut moms prowl neighborhood as zombies to raise money for breast cancer research
"It’s a bonding experience," Kate Garin, 39, an accountant in Fairfield, Connecticut, told Fox News Digital.
"Many in our group are survivors," she said, "so to be able to connect with women and share stories and have someone to turn to if, God forbid, this happens to you, it’s very touching. It’s incredible how strong these women are and how amazing they are. And we’re having a lot of fun while raising money."
TO RAISE MILLIONS FOR CANCER CHARITIES, ONE CEO WILL TREK ACROSS THE SOUTH POLE: 'A RISK WORTH TAKING'
The Mombies — a group of nurses, doctors, lawyers, accountants and more — meet in secret for several weeks before Halloween.
They select a theme and music, a mashup that always includes Michael Jackson’s "Thriller." They also work with professional choreographers and finetune their costumes.
"There's a lot of planning that goes into place and there's a lot of commitment and hard work, but it pays off," Garin said. |
21696 | Connecticut moms prowl neighborhood as zombies to raise money for breast cancer research
"Many in our group are survivors," she said, "so to be able to connect with women and share stories and have someone to turn to if, God forbid, this happens to you, it’s very touching. It’s incredible how strong these women are and how amazing they are. And we’re having a lot of fun while raising money."
TO RAISE MILLIONS FOR CANCER CHARITIES, ONE CEO WILL TREK ACROSS THE SOUTH POLE: 'A RISK WORTH TAKING'
The Mombies — a group of nurses, doctors, lawyers, accountants and more — meet in secret for several weeks before Halloween.
They select a theme and music, a mashup that always includes Michael Jackson’s "Thriller." They also work with professional choreographers and finetune their costumes.
"There's a lot of planning that goes into place and there's a lot of commitment and hard work, but it pays off," Garin said.
CALIFORNIA WOMAN WITH STAGE 4 BREAST CANCER DENIED MAMMOGRAM AT AGE 29: 'I'LL BE FIGHTING FOREVER'
"We're all working moms and we all have kids and lacrosse tournaments and baseball tournaments. |
21697 | Connecticut moms prowl neighborhood as zombies to raise money for breast cancer research
And we’re having a lot of fun while raising money."
TO RAISE MILLIONS FOR CANCER CHARITIES, ONE CEO WILL TREK ACROSS THE SOUTH POLE: 'A RISK WORTH TAKING'
The Mombies — a group of nurses, doctors, lawyers, accountants and more — meet in secret for several weeks before Halloween.
They select a theme and music, a mashup that always includes Michael Jackson’s "Thriller." They also work with professional choreographers and finetune their costumes.
"There's a lot of planning that goes into place and there's a lot of commitment and hard work, but it pays off," Garin said.
CALIFORNIA WOMAN WITH STAGE 4 BREAST CANCER DENIED MAMMOGRAM AT AGE 29: 'I'LL BE FIGHTING FOREVER'
"We're all working moms and we all have kids and lacrosse tournaments and baseball tournaments. And so, you know, we try to weave it all in," she added. |
21698 | Connecticut moms prowl neighborhood as zombies to raise money for breast cancer research
TO RAISE MILLIONS FOR CANCER CHARITIES, ONE CEO WILL TREK ACROSS THE SOUTH POLE: 'A RISK WORTH TAKING'
The Mombies — a group of nurses, doctors, lawyers, accountants and more — meet in secret for several weeks before Halloween.
They select a theme and music, a mashup that always includes Michael Jackson’s "Thriller." They also work with professional choreographers and finetune their costumes.
"There's a lot of planning that goes into place and there's a lot of commitment and hard work, but it pays off," Garin said.
CALIFORNIA WOMAN WITH STAGE 4 BREAST CANCER DENIED MAMMOGRAM AT AGE 29: 'I'LL BE FIGHTING FOREVER'
"We're all working moms and we all have kids and lacrosse tournaments and baseball tournaments. And so, you know, we try to weave it all in," she added.
Costume design and make up are a big part of the experience. |
21699 | Connecticut moms prowl neighborhood as zombies to raise money for breast cancer research
They select a theme and music, a mashup that always includes Michael Jackson’s "Thriller." They also work with professional choreographers and finetune their costumes.
"There's a lot of planning that goes into place and there's a lot of commitment and hard work, but it pays off," Garin said.
CALIFORNIA WOMAN WITH STAGE 4 BREAST CANCER DENIED MAMMOGRAM AT AGE 29: 'I'LL BE FIGHTING FOREVER'
"We're all working moms and we all have kids and lacrosse tournaments and baseball tournaments. And so, you know, we try to weave it all in," she added.
Costume design and make up are a big part of the experience.
"We have a couple of Mombies who are very talented in the makeup world," Garin said.
"Before the show, we'll get together in groups and help each other," she added. "Nobody does makeup on their own." |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.