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Jarred Younger: Thanks, Vicky. I am going to just go right in and introduce someone else, that's what I'm only doing most of today.
<|0.00|>Jarred Younger: Thanks, Vicky. I am going to just<|3.56|><|3.56|>go right in and introduce someone else, that's what I'm only doing most<|7.38|><|7.38|>of today.<|8.44|>
00:00:00.000
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I will turn it over to Trisha for the lived experience talk. Trisha Fisher: Thank you. My name is Trisha Fisher, I'm 40 years
<|0.00|>I will turn it over to Trisha for the lived experience talk.<|3.26|><|3.26|>Trisha Fisher:<|5.72|><|5.72|>Thank you. My name is Trisha Fisher,<|9.68|><|9.68|>I'm 40 years<|10.40|>
00:00:00.065
00:00:10.845
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radio label glucose tracer injected into patients, what was noticed that cold stimulate stimulated brown adipose tissue, glucose uptake in brown adipose tissue in Lean individuals.
<|0.00|>radio label glucose tracer injected into patients, what<|3.72|><|3.72|>was noticed that cold stimulate stimulated brown adipose<|7.54|><|7.54|>tissue, glucose uptake in brown adipose tissue in Lean individuals.<|11.40|>
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Dr. Davidson is the director of the Center for Cellular and Molecular Therapeutics and Chief Scientific Strategy officer at the Children's Hospital at Philadelphia and holds
<|0.00|>Dr. Davidson is the director of the Center for Cellular<|3.82|><|3.82|>and Molecular Therapeutics and Chief Scientific Strategy officer<|7.32|><|7.32|>at the Children's Hospital at Philadelphia and holds<|10.48|>
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disorders. She is associate director of the Center for Gene Therapy for cystic fibrosis and other genetic diseases. Her talk is titled "Advancing Therapies for CNS
<|0.00|>disorders. She is associate director of the Center for Gene<|3.58|><|3.58|>Therapy for cystic fibrosis and other genetic diseases.<|6.46|><|6.46|>Her talk is titled "Advancing Therapies for CNS<|9.70|>
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ataxias. For the CAG polyglutamine repeat diseases such a Huntington's and spinal cerebellar ataxias is a toxic gain of function mechanism. So the idea is we would like to develop
<|0.00|>ataxias. For the CAG polyglutamine repeat diseases<|3.84|><|3.84|>such a Huntington's and spinal cerebellar ataxias<|7.98|><|7.98|>is a toxic gain of function mechanism.<|11.04|><|11.04|>So the idea is we would like to develop<|14.24|>
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With this in mind, what we decided was to take a look at the mutant allele and scan upstream of the mutant allele and upstream of the axon 1 and downstream of
<|0.00|>With this in mind, what we decided was to take a look at the<|3.60|><|3.60|>mutant allele and scan upstream<|7.84|><|7.84|>of the mutant allele and upstream of the<|11.46|><|11.46|>axon 1 and downstream of<|13.62|>
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the limitations of the diagnostic testing for Sjogren's syndrome the diagnostic testing for Sjogren's is horrendous needs to improve it lacks sensitivity I'll talk a bit about
<|0.00|>the limitations of the diagnostic testing for Sjogren's syndrome<|3.98|><|3.98|>the diagnostic testing for Sjogren's is horrendous<|7.66|><|7.66|>needs to improve it lacks sensitivity<|11.48|><|11.48|>I'll talk a bit about<|13.64|>
00:00:00.506
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by dis aughtta know me and dysautonomia i think is best considered a more general generalized term to describe autonomic dysfunction so that can include pots but it's not limited to it
<|0.00|>by dis aughtta know me and dysautonomia i think is<|3.90|><|3.90|>best considered a more general generalized term<|7.64|><|7.64|>to describe autonomic dysfunction so that can<|11.20|><|11.20|>include pots but it's not limited to it<|13.84|>
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with a reduced risk of first hospitalization compared to Placebo or standard of care so yes the confidence intervals were wide but the results
<|0.00|>with a reduced risk of first hospitalization compared to Placebo<|3.86|><|3.86|>or standard of care so yes the confidence<|7.72|><|7.72|>intervals were wide but the results<|9.92|>
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really no one authors were found in their systematic review of 15 rcts including about 6 300 patients that vessel time of year was not
<|0.00|>really no one authors were found in their systematic<|3.72|><|3.72|>review of 15 rcts including about 6 300 patients<|7.88|><|7.88|>that vessel time of year was not<|9.96|>
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on to bacterial do you listen be sure to listen to this week in microbiology so uh the article inappropriate antibiotic prescribing and its determinants
<|0.00|>on to bacterial do you listen be sure to listen to this week<|3.64|><|3.64|>in microbiology so uh the article inappropriate<|7.76|><|7.76|>antibiotic prescribing and its determinants<|10.10|>
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in Uganda and that was his first responses seems like a lot of antibiotic prescribing going on here what should I do and I said Scott is a great time
<|0.00|>in Uganda and that was his first responses seems like a lot<|3.54|><|3.54|>of antibiotic prescribing going on here what should I do and I said<|7.22|><|7.22|>Scott is a great time<|9.30|>
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aged two and under in Madagascar Senegal and Cambodia involved the diagnosis that didn't require an antibiotic they looked at 11
<|0.00|>aged two and under in Madagascar Senegal and Cambodia<|3.56|><|3.56|>involved the diagnosis that didn't require an<|7.20|><|7.20|>antibiotic they looked at 11<|10.16|>
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antibiotic but still received one was 15.5 percent of Madagascar 57 in Cambodia 57 in Senegal and and I have to say uh recently a colleague of mine
<|0.00|>antibiotic but still received one was 15.5 percent<|4.12|><|4.12|>of Madagascar 57 in Cambodia 57<|7.90|><|7.90|>in Senegal and and I have to say<|11.68|><|11.68|>uh recently a colleague of mine<|13.58|>
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medicine so they reported that in this study more than are you ready three quarters of consultations resulting in an antibiotic prescription for
<|0.00|>medicine so they reported that in this study<|3.62|><|3.62|>more than are you ready three quarters of consultations<|7.92|><|7.92|>resulting in an antibiotic prescription for<|10.64|>
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So-- MARCIA CASTRO: That's the mean surface temperature. It started in 1880, and will go until 2022. OK, so that is a sobering picture of
<|0.00|>So-- MARCIA CASTRO: That's the mean surface temperature.<|3.40|><|3.40|>It started in 1880, and will go until 2022.<|7.80|><|7.80|>OK, so that is a sobering picture<|12.78|><|12.78|>of
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And Ari, it is up to you to sort of scope that problem for us. ARI BERNSTEIN: No problem. So thank you, Sarah, for
<|0.00|>And Ari, it is up to you to<|4.00|><|4.00|>sort of scope that problem for us.<|6.20|><|6.20|>ARI BERNSTEIN: No problem. So thank you,<|9.82|><|9.82|>Sarah, for
00:00:00.254
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[inquisitive string music] Some communities believed the disease was genetic; others thought it was contagious. Some thought it was caused by foul
<|0.00|>[inquisitive string music] Some communities believed<|3.52|><|3.52|>the disease was genetic; others thought it was contagious.<|6.68|><|6.68|>Some thought it was caused by foul<|8.70|>
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explosion population growth, spreading poverty, global warming, and urban migration, and what we're finding is new pathogens
<|0.00|>explosion population growth, spreading poverty, global<|4.46|><|4.46|>warming, and urban migration, and what<|7.96|><|7.96|>we're finding is new pathogens<|10.52|>
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It's increased. If we have a disease outbreak in Kuala Lumpur, in a day, the person that gets on that airplane with an infectious disease can be in Chicago in that same day. So
<|0.00|>It's increased. If we have a disease outbreak in Kuala<|3.76|><|3.76|>Lumpur, in a day, the person that gets<|7.40|><|7.40|>on that airplane with an infectious disease<|11.24|><|11.24|>can be in Chicago in that same day.<|14.10|><|14.10|>So<|14.84|>
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you're infected. And of the big problems with a possible influenza epidemic is if you catch flu bug--influenza--you are
<|0.00|>you're infected. And of the big problems<|3.54|><|3.54|>with a possible influenza epidemic is<|7.10|><|7.10|>if you catch flu bug--influenza--you<|11.46|><|11.46|>are<|12.34|>
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but those are the types of diseases that are carried by things like ticks, mosquitoes, tsetse
<|0.00|>but those are the types of diseases that are carried by things like<|3.60|><|3.60|>ticks, mosquitoes, tsetse<|6.84|>
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These are organisms like Campylobacter jejuni and Salmonella enterica. We tend to have these crises, because romaine
<|0.00|>These are organisms like Campylobacter jejuni and Salmonella<|3.78|><|3.78|>enterica. We tend to have these crises,<|7.30|><|7.30|>because romaine<|10.60|>
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And he can even figure out when you're in trouble and this infection is gonna be bad, and when you're gonna clear the
<|0.00|>And he can even figure out when you're in trouble and<|3.60|><|3.60|>this infection is gonna be bad, and when you're gonna clear the<|6.54|>
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I'm just going to share my screen. We have been very lucky the last few years to
<|0.00|>I'm just going to share my screen.<|3.60|><|3.60|>We have been very lucky the last few<|7.12|><|7.12|>years to<|7.98|>
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Probably all these different, both environmental etiological biological factors are interacting both with the proteinopathy as
<|0.00|>Probably all these different, both environmental<|3.68|><|3.68|>etiological biological factors are interacting<|7.66|><|7.66|>both with the proteinopathy as<|9.36|>
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we just had these RFA on etiology of AD/ADRD. We're having another one coming up on immunity. We have had in the
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he's disease-free so he's out well i was i wasn't the first to do this there were some other uh authors who who'd done this before uh there were a few stage 2a seminomas
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it turns out i wasn't and you know dissection pain planes were normal at the time our length of state was three three days this was early on in 2000 uh uh 11 through 14 and
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uh from two uh that that's our series with with uh uh brian who who was our fellow is who's now at loma linda and the kopi on this on this trial with me so when you look at
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- I think in every surgeon's career you're gonna do tons of surgeries over the course of your surgical
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patients in the country. I've operated across the globe in first and third world countries. My experiences taught me the
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These are our cases. - [Madeline] My name is Madeline Garcia. AKA
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see that again. - 10 years later, it doubled in size. It was getting where even family
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(laughing) So she went. - I've seen tons of carotid tumors. I've seen them all over the
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um we are very very fortunate to have today dr kim scarsey dr kim
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can answer while i'm talking uh you know in the zoom world sometimes you end up just kind
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okay all right so kind of a mix there um all right let's see if i can successfully share my screen that's
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well so as i mentioned we will talk about kind of broadly all of the different pharmacy careers in
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university i didn't grow up knowing that i wanted to be a pharmacist i actually when i registered for drake i was
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pharmacokinetics later in your your farmside curriculum this year so i'm always happy to have a chance to interact with the students a little
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um which means that i spend about 70 percent of my time on on research so i get to spend most of my time with you in infectious diseases
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sounds like two different extremes... how did I get interested in coupling them? Well, I was always interested, but the point of no
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of how mathematics, or theoretical physics, and experimental biology can come together and produce novel
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and they shot at me, "Well, this is just a model -- what does it have to do with reality?" And I shot back at
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um at the time uh maybe giving away a little bit of my age here but uh pharmd was still an optional uh degree so most of my class uh
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Here is a normal liver, where all the cells are functioning properly. But, when due to some aberrations -- genetic, environmental, or some other reason --
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because, eventually, isn't that the goal? Alright, coming back to cancer... cancer... this word sends a shiver down our
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and limitations. Can we not actually couple their strengths together so that we can produce some new insights into the
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freeway and then travel all through the body, and take an exit at multiple distant organs to form metastases, to form secondary
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does the breast cancer metastasize? And the most intriguing thing about metastasis is that more than 80% of cancers,
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in organs where cells do not have the innate property to move or migrate. Let's talk about breast cancer, prostate cancer, lung cancer
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and where did you go to undergrad i went to the university of notre dame fighting irish and medical school and medical college of virginia that
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i'm sorry gap years like did you go straight from undergrad into medical straight from undergrad into no gap years i did i didn't
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loved the kids and i was also in the summertime one of the older kids sort of looking after the younger kids so and my uncle was a
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and i i did love most of the parents most of them were very good but you know every once in a while you get a
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wore on me i 8 of my 12 months of internship were every other night on call and then so that was
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in surgery i didn't feel like making rounds at you know 4 30 in the morning and then again uh in the evening changing all the bandages i love
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surgery that was fun all right well you said you loved internal medicine and then now your infectious disease so what first
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chief of infectious diseases and told him my sad story that my money had fallen through i said is there any chance i could be
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And I saw that as an opportunity to pursue this passion, this lifelong passion of trying to do something for
<|0.00|>And I saw that as an opportunity to<|4.08|><|4.08|>pursue this passion, this lifelong passion of trying to do something<|7.94|><|7.94|>for
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And we'll answer your questions coming up right now on At the Forefront Live. And we want to remind our viewers
<|0.00|>And we'll answer your questions coming up right now on At the Forefront Live.<|3.48|><|3.48|>And we want to remind our viewers<|4.94|>
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seeing is, with some of the advances and in some areas, you're seeing more because of the fact, that folks are living longer and that's
<|0.00|>seeing is, with some of the advances and in some areas, you're<|3.94|><|3.94|>seeing more because of the fact, that folks<|7.46|><|7.46|>are living longer and that's<|9.64|>
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This is chapter nine in the neonatal protocol. Overview By the end of this chapter, I expect all participants
<|0.00|>This is chapter nine in the neonatal protocol.<|2.14|><|2.14|>Overview By the end of<|5.66|><|5.66|>this chapter, I expect all participants<|10.02|>
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A lumbar puncture should be considered if there is concern for meningitis, such as bulging fontanelle, lethargy, irritability,
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least 38 five or more and they may even have some GI symptoms which can deter the physician from making a specific diagnosis they will have nausea
<|0.00|>least 38 five or more and<|3.96|><|3.96|>they may even have some GI symptoms which can deter the<|7.56|><|7.56|>physician from making a specific diagnosis they<|11.86|><|11.86|>will have nausea<|12.80|>
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quality because the the sweat glands are slightly ademma tiss and you can feel the skin having sort of a rough texture to it some other conditions that
<|0.00|>quality because the the sweat glands<|3.80|><|3.80|>are slightly ademma tiss and you can feel the<|7.64|><|7.64|>skin having sort of a rough texture to it some<|11.46|><|11.46|>other conditions that<|13.42|>
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and you should note the white plaques that you find they can be on the buccal mucosa and the posterior pharynx they can be on the tongue and the Pearl is
<|0.00|>and you should note the white plaques that<|4.50|><|4.50|>you find they can be on the buccal mucosa and the posterior<|8.00|><|8.00|>pharynx they can be on the tongue and the<|11.56|><|11.56|>Pearl is<|12.24|>
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ulcers on the soft palate and one thing about herpangina is most of the lesions tend to be posterior lis located in the pharynx we certainly wouldn't want
<|0.00|>ulcers on the soft palate and one thing about<|3.64|><|3.64|>herpangina is most of the lesions<|7.30|><|7.30|>tend to be posterior lis located in<|10.92|><|10.92|>the pharynx we certainly wouldn't want<|12.98|>
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together some people say like Chinese lettering and we don't find this in developed countries because people are immunized but in a developing country
<|0.00|>together some people say like Chinese lettering<|3.82|><|3.82|>and we don't find this in developed countries because<|7.48|><|7.48|>people are immunized but in<|11.04|><|11.04|>a developing country<|12.20|>
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deathly ill so we can't overlook the possibility of fuse o bacterium and Akram and lemierre's syndrome this is an organism that reportedly
<|0.00|>deathly ill so we can't overlook<|3.64|><|3.64|>the possibility of fuse o bacterium and Akram<|7.44|><|7.44|>and lemierre's syndrome this is<|11.24|><|11.24|>an organism that reportedly<|13.72|>
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SO SURGEON GENERAL ADAMS? [APPLAUSE] >> GOOD MORNING, EVERYONE. THANK YOU VERY MUCH FOR THAT KIND INTRODUCTION, RICH,
<|0.00|>SO SURGEON GENERAL ADAMS? [APPLAUSE] >><|6.58|><|6.58|>GOOD MORNING, EVERYONE. THANK YOU VERY<|10.12|><|10.12|>MUCH FOR THAT KIND INTRODUCTION, RICH,<|12.40|>
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SO IT'S SOMETHING THAT AFFECTS ME IN MULTIPLE WAYS AND I COULDN'T BE MORE PLEASED TO SEE ALL OF YOU HERE AND SO MANY ON THIS WEBCAST HELPING US COME UP WITH PRODUCTIVE SOLUTIONS
<|0.00|>SO IT'S SOMETHING THAT AFFECTS ME IN MULTIPLE WAYS AND I COULDN'T BE<|3.64|><|3.64|>MORE PLEASED TO SEE ALL OF YOU HERE AND<|7.14|><|7.14|>SO MANY ON THIS WEBCAST HELPING US COME<|10.78|><|10.78|>UP WITH PRODUCTIVE SOLUTIONS<|13.04|>
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foreign [Applause] I am myself Dr Rajesh gubba I am the general medicine
<|0.00|>foreign [Applause] I<|3.66|><|3.66|>am myself Dr Rajesh gubba I am the general medicine<|6.84|>
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is the point when the organism entering into the body and development of full-blown AIDS it will take almost 10 years okay so this is basically we
<|0.00|>is the point when the organism entering into the body and<|3.52|><|3.52|>development of full-blown AIDS it will take almost 10 years<|7.28|><|7.28|>okay so this is basically we<|11.00|>
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encephalopathy so this will be a form of a full-blown AIDS and it takes almost 10 years all right that was the first question second question is which of
<|0.00|>encephalopathy so this will be a form of a<|3.62|><|3.62|>full-blown AIDS and it takes almost 10 years all right<|7.24|><|7.24|>that was the first question second question is which<|10.98|><|10.98|>of
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screened for HIV two it's an incorrect statement so donated blood it is screened for both HIV one and as well as the HIV two all right so the
<|0.00|>screened for HIV two it's an incorrect statement so donated<|3.72|><|3.72|>blood it is screened for both HIV one and as well as the HIV<|7.46|><|7.46|>two all right so the<|10.78|>
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you take the DC sign what is DC sign DC sign is a type of cell surface lectin receptor right it is a type of it is a type
<|0.00|>you take the DC sign what is DC sign DC sign<|3.56|><|3.56|>is a type of cell surface lectin<|7.58|><|7.58|>receptor right it is a type of<|11.08|><|11.08|>it is a type<|12.88|>
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receptor that is lectin receptor where is it present it is present on the dendritic cells they are nothing but the antigen presenting cells so on
<|0.00|>receptor that is lectin receptor where is it present<|3.56|><|3.56|>it is present on the dendritic cells<|7.12|><|7.12|>they are nothing but the antigen presenting cells so on<|10.16|>
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cell surface leptin receptors to which the HIV has the Affinity to bind right to which the HIV has Affinity to bind now the expression of this
<|0.00|>cell surface leptin receptors to which the HIV<|3.88|><|3.88|>has the Affinity to bind right to which<|7.56|><|7.56|>the HIV has Affinity to bind now the<|11.20|><|11.20|>expression of this<|12.48|>
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acoustic neuromas, meningiomas and others. - Okay. Thank you
<|0.00|>acoustic neuromas, meningiomas<|4.32|><|4.32|>and others.<|6.02|><|6.02|>- Okay. Thank you<|7.90|>
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I'm gonna turn now to Dr. Satinsky. Welcome. - Thank you. - Thank you for joining us. Can you start off by introducing yourself to our viewers?
<|0.00|>I'm gonna turn now to Dr. Satinsky.<|2.16|><|2.16|>Welcome. - Thank you.<|4.26|><|4.26|>- Thank you for joining us. Can you start off by introducing yourself to our viewers?<|8.74|>
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row_001196.wav
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fireworks/whisper-v3
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surgeons do i know that's probably uh unpopular uh thought amongst you know id people but you've got to know the anatomy you
<|0.00|>surgeons do i know that's probably uh unpopular uh<|4.10|><|4.10|>thought amongst you know id people but you've got to know the<|7.60|><|7.60|>anatomy you
00:00:00.000
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row_001249.wav
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fireworks/whisper-v3
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has a hemoshield graph in addition he also has a pacemaker so just to kind of remind everybody what a corruptation of the order is you probably remember but still um you know the defect can occur anywhere
<|0.00|>has a hemoshield graph in addition he also has a pacemaker<|3.80|><|3.80|>so just to kind of remind everybody what a corruptation of the order is you<|7.68|><|7.68|>probably remember but still um you know the defect can occur anywhere<|11.18|>
00:00:00.000
00:00:12.320
12.32
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row_001254.wav
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fireworks/whisper-v3
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it was repaired at uf shan's at age one month and had a revision when he was about a little bit over 10 years old and
<|0.00|>it was repaired at uf shan's at age one<|3.72|><|3.72|>month and had a revision when he was about a little bit over<|7.48|><|7.48|>10 years old and<|8.66|>
00:00:00.000
00:00:10.000
10
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row_001253.wav
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fireworks/whisper-v3
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the construction per se uh but he does oversee it and he is on the job sites uh so his hobbies are fresh water and
<|0.00|>the construction per se uh but he does oversee<|3.88|><|3.88|>it and he is on the job sites uh so his hobbies are fresh water<|7.62|><|7.62|>and<|10.32|>
00:00:00.000
00:00:10.320
10.32
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row_001262.wav
en
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fireworks/whisper-v3
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from time to time chews on the inside of his buccal mucosa uh you know so he he has no drug alert no drug
<|0.00|>from time to time chews on the inside of his buccal mucosa<|3.84|><|3.84|>uh you know so he he has no drug alert<|7.42|><|7.42|>no drug<|7.92|>
00:00:00.000
00:00:10.160
8.371
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row_001258.wav
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fireworks/whisper-v3
0.8761
End of preview. Expand in Data Studio

Dropped Samples

Samples removed during filtering of None.

These had CER >= 47% against filter model fireworks/whisper-v3, indicating unreliable reference transcriptions.

Columns

Column Description
audio Audio sample
text Original reference transcription
filter_prediction Filter model prediction
filter_cer CER between filter prediction and reference
filter_model Model used for filter CER computation
filter_confidence Geometric mean word confidence (if available)

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