prompt stringlengths 2.15k 5.36k | title stringclasses 394
values | abstract stringclasses 394
values | head_entity dict | title_entity dict | candidate_relation_list listlengths 3 7 | label stringclasses 8
values |
|---|---|---|---|---|---|---|
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein Hepatocyte nuclear factor-6 and a disease type II diabetes in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The me... | Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion. | The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus... | {
"name": "Hepatocyte nuclear factor-6",
"type": "GeneOrGeneProduct"
} | {
"name": "type II diabetes",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical glucose and a gene or protein insulin in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of each relat... | Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion. | The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus... | {
"name": "glucose",
"type": "ChemicalEntity"
} | {
"name": "insulin",
"type": "GeneOrGeneProduct"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical glucose and a disease Type II diabetes mellitus in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each re... | Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion. | The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus... | {
"name": "glucose",
"type": "ChemicalEntity"
} | {
"name": "Type II diabetes mellitus",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein type II Ca2+-dependent lectin and a chemical mannose in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The m... | Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. | We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin. LC are uniquely characterized by Birbeck granules (BG), which are organelles consisting of superimposed and zippered membranes. Here, we have shown that Langerin... | {
"name": "type II Ca2+-dependent lectin",
"type": "GeneOrGeneProduct"
} | {
"name": "mannose",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Bind |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease breast cancer and a variant 5382insC in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type ... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "breast cancer",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "5382insC",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease breast cancer and a variant 4153delA in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type ... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "breast cancer",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "4153delA",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease breast cancer and a variant C61G in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are ... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "breast cancer",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "C61G",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease ovarian cancer and a variant 5382insC in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "ovarian cancer",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "5382insC",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease ovarian cancer and a variant 4153delA in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "ovarian cancer",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "4153delA",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease ovarian cancer and a variant C61G in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "ovarian cancer",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "C61G",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant 5382insC and a disease breast-ovarian cancer syndrome in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of ea... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "5382insC",
"type": "SequenceVariant"
} | {
"name": "breast-ovarian cancer syndrome",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant 4153delA and a disease breast-ovarian cancer syndrome in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of ea... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "4153delA",
"type": "SequenceVariant"
} | {
"name": "breast-ovarian cancer syndrome",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant C61G and a disease breast-ovarian cancer syndrome in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each r... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "C61G",
"type": "SequenceVariant"
} | {
"name": "breast-ovarian cancer syndrome",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease BRCA1 abnormalities and a variant 5382insC in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1 abnormalities",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "5382insC",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease BRCA1 abnormalities and a variant 4153delA in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1 abnormalities",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "4153delA",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease BRCA1 abnormalities and a variant C61G in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation typ... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1 abnormalities",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "C61G",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein BRCA1 and a disease breast cancers in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1",
"type": "GeneOrGeneProduct"
} | {
"name": "breast cancers",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein BRCA1 and a disease ovarian cancer in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1",
"type": "GeneOrGeneProduct"
} | {
"name": "ovarian cancer",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein BRCA1 and a disease BRCA1 abnormalities in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each rel... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1",
"type": "GeneOrGeneProduct"
} | {
"name": "BRCA1 abnormalities",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein BRCA1 and a disease breast-ovarian cancer in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each r... | Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. | We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the thre... | {
"name": "BRCA1",
"type": "GeneOrGeneProduct"
} | {
"name": "breast-ovarian cancer",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical levodopa and a disease dyskinesias in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type a... | Apomorphine: an underutilized therapy for Parkinson's disease. | Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of syst... | {
"name": "levodopa",
"type": "ChemicalEntity"
} | {
"name": "dyskinesias",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical apomorphine and a chemical levodopa in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association'], based only on the informa... | Apomorphine: an underutilized therapy for Parkinson's disease. | Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of syst... | {
"name": "apomorphine",
"type": "ChemicalEntity"
} | {
"name": "levodopa",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Drug_Interaction",
"Cotreatment",
"Conversion",
"Comparison",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical apomorphine and a disease dyskinesias in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation typ... | Apomorphine: an underutilized therapy for Parkinson's disease. | Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of syst... | {
"name": "apomorphine",
"type": "ChemicalEntity"
} | {
"name": "dyskinesias",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical Apomorphine and a disease Parkinson's disease in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each rela... | Apomorphine: an underutilized therapy for Parkinson's disease. | Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of syst... | {
"name": "Apomorphine",
"type": "ChemicalEntity"
} | {
"name": "Parkinson's disease",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease uterine sarcoma and a gene or protein Rab6c in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relatio... | Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. | A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and... | {
"name": "uterine sarcoma",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "Rab6c",
"type": "GeneOrGeneProduct"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein Rab6c and a chemical vincristine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of each rel... | Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. | A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and... | {
"name": "Rab6c",
"type": "GeneOrGeneProduct"
} | {
"name": "vincristine",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein Rab6c and a chemical vinblastine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of each rel... | Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. | A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and... | {
"name": "Rab6c",
"type": "GeneOrGeneProduct"
} | {
"name": "vinblastine",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein Rab6c and a chemical taxol in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of each relation ... | Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. | A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and... | {
"name": "Rab6c",
"type": "GeneOrGeneProduct"
} | {
"name": "taxol",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein Rab6c and a chemical doxorubicin in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of each rel... | Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. | A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and... | {
"name": "Rab6c",
"type": "GeneOrGeneProduct"
} | {
"name": "doxorubicin",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein calcineurin and a chemical tacrolimus in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of eac... | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). Thi... | {
"name": "calcineurin",
"type": "GeneOrGeneProduct"
} | {
"name": "tacrolimus",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein calcineurin and a chemical cyclosporine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of e... | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). Thi... | {
"name": "calcineurin",
"type": "GeneOrGeneProduct"
} | {
"name": "cyclosporine",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease hepatorenal syndrome and a chemical creatinine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each rela... | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). Thi... | {
"name": "hepatorenal syndrome",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "creatinine",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical tacrolimus and a disease nephrotoxic in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type... | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). Thi... | {
"name": "tacrolimus",
"type": "ChemicalEntity"
} | {
"name": "nephrotoxic",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease CRF and a chemical creatinine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are as ... | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). Thi... | {
"name": "CRF",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "creatinine",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical cyclosporine and a disease nephrotoxic in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation ty... | End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). Thi... | {
"name": "cyclosporine",
"type": "ChemicalEntity"
} | {
"name": "nephrotoxic",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein SOD1 and a disease amyotrophic lateral sclerosis in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of ... | D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype. | More than 100 different heterozygous mutations in copper/zinc superoxide dismutase (SOD1) have been found in patients with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Uniquely, D90A-SOD1 has been identified in recessive, dominant and apparently sporadic pedigrees. The phenotype of homozygote... | {
"name": "SOD1",
"type": "GeneOrGeneProduct"
} | {
"name": "amyotrophic lateral sclerosis",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant D90A and a disease ALS in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are as follows... | D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype. | More than 100 different heterozygous mutations in copper/zinc superoxide dismutase (SOD1) have been found in patients with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Uniquely, D90A-SOD1 has been identified in recessive, dominant and apparently sporadic pedigrees. The phenotype of homozygote... | {
"name": "D90A",
"type": "SequenceVariant"
} | {
"name": "ALS",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein arylsulfatase A and a disease metachromatic leukodystrophy in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The me... | Late-onset metachromatic leukodystrophy: molecular pathology in two siblings. | We report on a new allele at the arylsulfatase A (ARSA) locus causing late-onset metachromatic leukodystrophy (MLD). In that allele arginine84, a residue that is highly conserved in the arylsulfatase gene family, is replaced by glutamine. In contrast to alleles that cause early-onset MLD, the arginine84 to glutamine su... | {
"name": "arylsulfatase A",
"type": "GeneOrGeneProduct"
} | {
"name": "metachromatic leukodystrophy",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant arginine84 and a disease MLD in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are as f... | Late-onset metachromatic leukodystrophy: molecular pathology in two siblings. | We report on a new allele at the arylsulfatase A (ARSA) locus causing late-onset metachromatic leukodystrophy (MLD). In that allele arginine84, a residue that is highly conserved in the arylsulfatase gene family, is replaced by glutamine. In contrast to alleles that cause early-onset MLD, the arginine84 to glutamine su... | {
"name": "arginine84",
"type": "SequenceVariant"
} | {
"name": "MLD",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein GJB2 and a disease non-syndromic autosomal recessive deafness in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The... | Low frequency of deafness-associated GJB2 variants in Kenya and Sudan and novel GJB2 variants. | A large proportion of non-syndromic autosomal recessive deafness (NSARD) in many populations is caused by variants of the GJB2 gene. Here, the frequency of GJB2 variants was studied in 406 and 183 apparently unrelated children from Kenya and Sudan, respectively, with mostly severe to profound non-syndromic deafness. Ni... | {
"name": "GJB2",
"type": "GeneOrGeneProduct"
} | {
"name": "non-syndromic autosomal recessive deafness",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant N157K and a disease autosomal dominant hypercholesterolemia in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings ... | Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia. | Proprotein convertase subtilisin/kexin type 9 (PCSK9) is at a locus for autosomal dominant hypercholesterolemia, and recent data indicate that the PCSK9 gene is involved in cholesterol biosynthesis. Mutations within this gene have previously been found to segregate with hypercholesterolemia. In this study, DNA sequenci... | {
"name": "N157K",
"type": "SequenceVariant"
} | {
"name": "autosomal dominant hypercholesterolemia",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease autosomal dominant hypercholesterolemia and a gene or protein PCSK9 in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The m... | Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia. | Proprotein convertase subtilisin/kexin type 9 (PCSK9) is at a locus for autosomal dominant hypercholesterolemia, and recent data indicate that the PCSK9 gene is involved in cholesterol biosynthesis. Mutations within this gene have previously been found to segregate with hypercholesterolemia. In this study, DNA sequenci... | {
"name": "autosomal dominant hypercholesterolemia",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "PCSK9",
"type": "GeneOrGeneProduct"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein PCSK9 and a chemical cholesterol in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of each rel... | Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia. | Proprotein convertase subtilisin/kexin type 9 (PCSK9) is at a locus for autosomal dominant hypercholesterolemia, and recent data indicate that the PCSK9 gene is involved in cholesterol biosynthesis. Mutations within this gene have previously been found to segregate with hypercholesterolemia. In this study, DNA sequenci... | {
"name": "PCSK9",
"type": "GeneOrGeneProduct"
} | {
"name": "cholesterol",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein PCSK9 and a disease hypercholesterolemia in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each re... | Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia. | Proprotein convertase subtilisin/kexin type 9 (PCSK9) is at a locus for autosomal dominant hypercholesterolemia, and recent data indicate that the PCSK9 gene is involved in cholesterol biosynthesis. Mutations within this gene have previously been found to segregate with hypercholesterolemia. In this study, DNA sequenci... | {
"name": "PCSK9",
"type": "GeneOrGeneProduct"
} | {
"name": "hypercholesterolemia",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant D374Y and a disease autosomal dominant hypercholesterolemia in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings ... | Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia. | Proprotein convertase subtilisin/kexin type 9 (PCSK9) is at a locus for autosomal dominant hypercholesterolemia, and recent data indicate that the PCSK9 gene is involved in cholesterol biosynthesis. Mutations within this gene have previously been found to segregate with hypercholesterolemia. In this study, DNA sequenci... | {
"name": "D374Y",
"type": "SequenceVariant"
} | {
"name": "autosomal dominant hypercholesterolemia",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease hypercholesterolemia and a variant D374Y in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation t... | Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia. | Proprotein convertase subtilisin/kexin type 9 (PCSK9) is at a locus for autosomal dominant hypercholesterolemia, and recent data indicate that the PCSK9 gene is involved in cholesterol biosynthesis. Mutations within this gene have previously been found to segregate with hypercholesterolemia. In this study, DNA sequenci... | {
"name": "hypercholesterolemia",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "D374Y",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein alpha-B crystallin and a disease DRM in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relati... | Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene. | Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin. Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases. The genetic basis of the other forms remain unknown, including... | {
"name": "alpha-B crystallin",
"type": "GeneOrGeneProduct"
} | {
"name": "DRM",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein desmin and a disease DRMs in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are... | Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene. | Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin. Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases. The genetic basis of the other forms remain unknown, including... | {
"name": "desmin",
"type": "GeneOrGeneProduct"
} | {
"name": "DRMs",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein SEPN1 and a disease multiminicore disease in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each r... | Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene. | Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin. Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases. The genetic basis of the other forms remain unknown, including... | {
"name": "SEPN1",
"type": "GeneOrGeneProduct"
} | {
"name": "multiminicore disease",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein SEPN1 and a disease rigid spine muscular dystrophy in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings o... | Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene. | Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin. Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases. The genetic basis of the other forms remain unknown, including... | {
"name": "SEPN1",
"type": "GeneOrGeneProduct"
} | {
"name": "rigid spine muscular dystrophy",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein SEPN1 and a disease SEPN-related myopathy in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each r... | Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene. | Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin. Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases. The genetic basis of the other forms remain unknown, including... | {
"name": "SEPN1",
"type": "GeneOrGeneProduct"
} | {
"name": "SEPN-related myopathy",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease DRM and a variant del 92 nucleotide -19/+73 in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relatio... | Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene. | Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin. Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases. The genetic basis of the other forms remain unknown, including... | {
"name": "DRM",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "del 92 nucleotide -19/+73",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease Desmin-related myopathy and a gene or protein selenoprotein N in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meaning... | Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene. | Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin. Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases. The genetic basis of the other forms remain unknown, including... | {
"name": "Desmin-related myopathy",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "selenoprotein N",
"type": "GeneOrGeneProduct"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein Tuple1 and a disease DiGeorge and Velocardiofacial syndromes in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The ... | Altered replication timing of the HIRA/Tuple1 locus in the DiGeorge and Velocardiofacial syndromes. | DiGeorge and Velocardiofacial syndromes (DGS/VCFS) are endowed by a similar complex phenotype including cardiovascular, craniofacial, and thymic malformations, and are associated with heterozygous deletions of 22q11 chromosomal band. The Typically Deleted Region in the 22q11.21 subband (here called TDR22) is very gene-... | {
"name": "Tuple1",
"type": "GeneOrGeneProduct"
} | {
"name": "DiGeorge and Velocardiofacial syndromes",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical Catecholamine and a disease cardiomyopathy in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relatio... | Severe reversible left ventricular systolic and diastolic dysfunction due to accidental iatrogenic epinephrine overdose. | Catecholamine-induced cardiomyopathy due to chronic excess of endogenous catecholamines has been recognized for decades as a clinical phenomenon. In contrast, reports of myocardial dysfunction due to acute iatrogenic overdose are rare. A 35-year-old woman whose cervix uteri was inadvertently injected with 8 mg of epine... | {
"name": "Catecholamine",
"type": "ChemicalEntity"
} | {
"name": "cardiomyopathy",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease cardiomyopathy and a chemical epinephrine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation ... | Severe reversible left ventricular systolic and diastolic dysfunction due to accidental iatrogenic epinephrine overdose. | Catecholamine-induced cardiomyopathy due to chronic excess of endogenous catecholamines has been recognized for decades as a clinical phenomenon. In contrast, reports of myocardial dysfunction due to acute iatrogenic overdose are rare. A 35-year-old woman whose cervix uteri was inadvertently injected with 8 mg of epine... | {
"name": "cardiomyopathy",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "epinephrine",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical epinephrine and a disease myocardial stunning in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each rela... | Severe reversible left ventricular systolic and diastolic dysfunction due to accidental iatrogenic epinephrine overdose. | Catecholamine-induced cardiomyopathy due to chronic excess of endogenous catecholamines has been recognized for decades as a clinical phenomenon. In contrast, reports of myocardial dysfunction due to acute iatrogenic overdose are rare. A 35-year-old woman whose cervix uteri was inadvertently injected with 8 mg of epine... | {
"name": "epinephrine",
"type": "ChemicalEntity"
} | {
"name": "myocardial stunning",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease left ventricular systolic and diastolic dysfunction and a chemical epinephrine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the... | Severe reversible left ventricular systolic and diastolic dysfunction due to accidental iatrogenic epinephrine overdose. | Catecholamine-induced cardiomyopathy due to chronic excess of endogenous catecholamines has been recognized for decades as a clinical phenomenon. In contrast, reports of myocardial dysfunction due to acute iatrogenic overdose are rare. A 35-year-old woman whose cervix uteri was inadvertently injected with 8 mg of epine... | {
"name": "left ventricular systolic and diastolic dysfunction",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "epinephrine",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease thrombotic and a chemical aspirin in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are... | Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis. | There have been concerns that the risk of cardiovascular thrombotic events may be higher with cyclooxygenase (COX)-2-specific inhibitors than nonselective nonsteroidal antiinflammatory drugs (NSAIDs). We evaluated cardiovascular event data for valdecoxib, a new COX-2-specific inhibitor in approximately 8000 patients wi... | {
"name": "thrombotic",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "aspirin",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical valdecoxib and a disease rheumatoid arthritis in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each rela... | Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis. | There have been concerns that the risk of cardiovascular thrombotic events may be higher with cyclooxygenase (COX)-2-specific inhibitors than nonselective nonsteroidal antiinflammatory drugs (NSAIDs). We evaluated cardiovascular event data for valdecoxib, a new COX-2-specific inhibitor in approximately 8000 patients wi... | {
"name": "valdecoxib",
"type": "ChemicalEntity"
} | {
"name": "rheumatoid arthritis",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical valdecoxib and a disease osteoarthritis in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation t... | Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis. | There have been concerns that the risk of cardiovascular thrombotic events may be higher with cyclooxygenase (COX)-2-specific inhibitors than nonselective nonsteroidal antiinflammatory drugs (NSAIDs). We evaluated cardiovascular event data for valdecoxib, a new COX-2-specific inhibitor in approximately 8000 patients wi... | {
"name": "valdecoxib",
"type": "ChemicalEntity"
} | {
"name": "osteoarthritis",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical valdecoxib and a chemical nonsteroidal antiinflammatory agents in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association']... | Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis. | There have been concerns that the risk of cardiovascular thrombotic events may be higher with cyclooxygenase (COX)-2-specific inhibitors than nonselective nonsteroidal antiinflammatory drugs (NSAIDs). We evaluated cardiovascular event data for valdecoxib, a new COX-2-specific inhibitor in approximately 8000 patients wi... | {
"name": "valdecoxib",
"type": "ChemicalEntity"
} | {
"name": "nonsteroidal antiinflammatory agents",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Drug_Interaction",
"Cotreatment",
"Conversion",
"Comparison",
"Association"
] | Comparison |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical valdecoxib and a disease arthritis in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type a... | Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis. | There have been concerns that the risk of cardiovascular thrombotic events may be higher with cyclooxygenase (COX)-2-specific inhibitors than nonselective nonsteroidal antiinflammatory drugs (NSAIDs). We evaluated cardiovascular event data for valdecoxib, a new COX-2-specific inhibitor in approximately 8000 patients wi... | {
"name": "valdecoxib",
"type": "ChemicalEntity"
} | {
"name": "arthritis",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein cyclooxygenase-2 and a chemical valdecoxib in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of... | Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis. | There have been concerns that the risk of cardiovascular thrombotic events may be higher with cyclooxygenase (COX)-2-specific inhibitors than nonselective nonsteroidal antiinflammatory drugs (NSAIDs). We evaluated cardiovascular event data for valdecoxib, a new COX-2-specific inhibitor in approximately 8000 patients wi... | {
"name": "cyclooxygenase-2",
"type": "GeneOrGeneProduct"
} | {
"name": "valdecoxib",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant nine nucleotide insertion and a disease WFS in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relatio... | Identification of a novel WFS1 mutation (AFF344-345ins) in Japanese patients with Wolfram syndrome. | Wolfram syndrome (WFS) is an autosomal recessive disorder characterized by early onset diabetes mellitus, progressive optic atrophy, sensorineural deafness and diabetes insipidus. Affected individuals may also have renal tract abnormalities as well as neurogical and psychiatric syndromes. WFS1 encoding a transmembrane ... | {
"name": "nine nucleotide insertion",
"type": "SequenceVariant"
} | {
"name": "WFS",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein WFS1 and a disease WFS in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are as... | Identification of a novel WFS1 mutation (AFF344-345ins) in Japanese patients with Wolfram syndrome. | Wolfram syndrome (WFS) is an autosomal recessive disorder characterized by early onset diabetes mellitus, progressive optic atrophy, sensorineural deafness and diabetes insipidus. Affected individuals may also have renal tract abnormalities as well as neurogical and psychiatric syndromes. WFS1 encoding a transmembrane ... | {
"name": "WFS1",
"type": "GeneOrGeneProduct"
} | {
"name": "WFS",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant AFF344-345ins and a disease Wolfram syndrome in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relati... | Identification of a novel WFS1 mutation (AFF344-345ins) in Japanese patients with Wolfram syndrome. | Wolfram syndrome (WFS) is an autosomal recessive disorder characterized by early onset diabetes mellitus, progressive optic atrophy, sensorineural deafness and diabetes insipidus. Affected individuals may also have renal tract abnormalities as well as neurogical and psychiatric syndromes. WFS1 encoding a transmembrane ... | {
"name": "AFF344-345ins",
"type": "SequenceVariant"
} | {
"name": "Wolfram syndrome",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical serotonin and a disease migraine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are... | A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach. | Migraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few genetic studies investig... | {
"name": "serotonin",
"type": "ChemicalEntity"
} | {
"name": "migraine",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical S-1 and a chemical 5-FU in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association'], based only on the information provide... | 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine. | Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies. We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. The patient, who had unresectable colon cancer metastases... | {
"name": "S-1",
"type": "ChemicalEntity"
} | {
"name": "5-FU",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Drug_Interaction",
"Cotreatment",
"Conversion",
"Comparison",
"Association"
] | Comparison |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease cardiac symptoms and a chemical S-1 in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type a... | 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine. | Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies. We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. The patient, who had unresectable colon cancer metastases... | {
"name": "cardiac symptoms",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "S-1",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease cardiotoxicity and a chemical S-1 in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are... | 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine. | Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies. We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. The patient, who had unresectable colon cancer metastases... | {
"name": "cardiotoxicity",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "S-1",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease cardiotoxicity and a chemical alpha-fluoro-beta-alanine in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of ... | 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine. | Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies. We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. The patient, who had unresectable colon cancer metastases... | {
"name": "cardiotoxicity",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "alpha-fluoro-beta-alanine",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease precordial pain and a chemical FBAL in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type a... | 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine. | Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies. We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. The patient, who had unresectable colon cancer metastases... | {
"name": "precordial pain",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "FBAL",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease precordial pain and a chemical 5-FU in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type a... | 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine. | Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies. We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. The patient, who had unresectable colon cancer metastases... | {
"name": "precordial pain",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "5-FU",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical FBAL and a chemical S-1 in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association'], based only on the information provide... | 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine. | Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies. We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. The patient, who had unresectable colon cancer metastases... | {
"name": "FBAL",
"type": "ChemicalEntity"
} | {
"name": "S-1",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Drug_Interaction",
"Cotreatment",
"Conversion",
"Comparison",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease right bundle branch block and a chemical FBAL in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relat... | 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine. | Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies. We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. The patient, who had unresectable colon cancer metastases... | {
"name": "right bundle branch block",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "FBAL",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical 5-FU and a disease malignancies in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type are ... | 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine. | Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies. We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. The patient, who had unresectable colon cancer metastases... | {
"name": "5-FU",
"type": "ChemicalEntity"
} | {
"name": "malignancies",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical 5-Fluorouracil and a disease cardiotoxicity in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relati... | 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine. | Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies. We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. The patient, who had unresectable colon cancer metastases... | {
"name": "5-Fluorouracil",
"type": "ChemicalEntity"
} | {
"name": "cardiotoxicity",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical 5-FU and a chemical FBAL in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association'], based only on the information provid... | 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine. | Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies. We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. The patient, who had unresectable colon cancer metastases... | {
"name": "5-FU",
"type": "ChemicalEntity"
} | {
"name": "FBAL",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Drug_Interaction",
"Cotreatment",
"Conversion",
"Comparison",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical 5-FU and a disease right bundle branch block in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relat... | 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine. | Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies. We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. The patient, who had unresectable colon cancer metastases... | {
"name": "5-FU",
"type": "ChemicalEntity"
} | {
"name": "right bundle branch block",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical Pilocarpine and a disease status epilepticus in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relat... | Pilocarpine seizures cause age-dependent impairment in auditory location discrimination. | Children who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was ... | {
"name": "Pilocarpine",
"type": "ChemicalEntity"
} | {
"name": "status epilepticus",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical Pilocarpine and a disease impairment in auditory location discrimination in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text... | Pilocarpine seizures cause age-dependent impairment in auditory location discrimination. | Children who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was ... | {
"name": "Pilocarpine",
"type": "ChemicalEntity"
} | {
"name": "impairment in auditory location discrimination",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical Pilocarpine and a disease seizures in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type a... | Pilocarpine seizures cause age-dependent impairment in auditory location discrimination. | Children who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was ... | {
"name": "Pilocarpine",
"type": "ChemicalEntity"
} | {
"name": "seizures",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein PTPN22 and a disease autoimmune conditions in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each ... | No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations. | INTRODUCTION: The PTPN22 is a negative regulator of the T cell response. Its +1858C>T (R620W) polymorphism has been shown to associate with a risk for multiple autoimmune diseases, including type 1 diabetes (T1D) and juvenile idiopathic arthritis (JIA). The minor (susceptibility) allele is absent in Asian populations, ... | {
"name": "PTPN22",
"type": "GeneOrGeneProduct"
} | {
"name": "autoimmune conditions",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein PTPN22 and a disease type 1 diabetes in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relati... | No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations. | INTRODUCTION: The PTPN22 is a negative regulator of the T cell response. Its +1858C>T (R620W) polymorphism has been shown to associate with a risk for multiple autoimmune diseases, including type 1 diabetes (T1D) and juvenile idiopathic arthritis (JIA). The minor (susceptibility) allele is absent in Asian populations, ... | {
"name": "PTPN22",
"type": "GeneOrGeneProduct"
} | {
"name": "type 1 diabetes",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein PTPN22 and a disease juvenile idiopathic arthritis in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings o... | No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations. | INTRODUCTION: The PTPN22 is a negative regulator of the T cell response. Its +1858C>T (R620W) polymorphism has been shown to associate with a risk for multiple autoimmune diseases, including type 1 diabetes (T1D) and juvenile idiopathic arthritis (JIA). The minor (susceptibility) allele is absent in Asian populations, ... | {
"name": "PTPN22",
"type": "GeneOrGeneProduct"
} | {
"name": "juvenile idiopathic arthritis",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant R620W and a disease autoimmune diseases in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation ty... | No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations. | INTRODUCTION: The PTPN22 is a negative regulator of the T cell response. Its +1858C>T (R620W) polymorphism has been shown to associate with a risk for multiple autoimmune diseases, including type 1 diabetes (T1D) and juvenile idiopathic arthritis (JIA). The minor (susceptibility) allele is absent in Asian populations, ... | {
"name": "R620W",
"type": "SequenceVariant"
} | {
"name": "autoimmune diseases",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant (W) allele at codon 620 and a disease T1D in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation ... | No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations. | INTRODUCTION: The PTPN22 is a negative regulator of the T cell response. Its +1858C>T (R620W) polymorphism has been shown to associate with a risk for multiple autoimmune diseases, including type 1 diabetes (T1D) and juvenile idiopathic arthritis (JIA). The minor (susceptibility) allele is absent in Asian populations, ... | {
"name": "(W) allele at codon 620",
"type": "SequenceVariant"
} | {
"name": "T1D",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant (R) allele at codon 620 and a disease JIA in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation ... | No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations. | INTRODUCTION: The PTPN22 is a negative regulator of the T cell response. Its +1858C>T (R620W) polymorphism has been shown to associate with a risk for multiple autoimmune diseases, including type 1 diabetes (T1D) and juvenile idiopathic arthritis (JIA). The minor (susceptibility) allele is absent in Asian populations, ... | {
"name": "(R) allele at codon 620",
"type": "SequenceVariant"
} | {
"name": "JIA",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant -1123 G>C and a variant +2740 A>G in a medical text. Choose the correct relation from ['Association', 'Positive_Correlation', 'Negative_Correlation'], based only on the information provided in the text.The meanings of each relation type are ... | No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations. | INTRODUCTION: The PTPN22 is a negative regulator of the T cell response. Its +1858C>T (R620W) polymorphism has been shown to associate with a risk for multiple autoimmune diseases, including type 1 diabetes (T1D) and juvenile idiopathic arthritis (JIA). The minor (susceptibility) allele is absent in Asian populations, ... | {
"name": "-1123 G>C",
"type": "SequenceVariant"
} | {
"name": "+2740 A>G",
"type": "SequenceVariant"
} | [
"Association",
"Positive_Correlation",
"Negative_Correlation"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant -511C/T and a variant -31T/C in a medical text. Choose the correct relation from ['Association', 'Positive_Correlation', 'Negative_Correlation'], based only on the information provided in the text.The meanings of each relation type are as fo... | A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population. | Proinflammatory cytokine gene polymorphisms have been demonstrated to associate with gastric cancer risk, of which IL1B-31T/C and -511C/T changes have been well investigated due to the possibility that they may alter the IL1B transcription. The signal transduction target upon interleukin 1 beta (IL1beta) stimulation, t... | {
"name": "-511C/T",
"type": "SequenceVariant"
} | {
"name": "-31T/C",
"type": "SequenceVariant"
} | [
"Association",
"Positive_Correlation",
"Negative_Correlation"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein NFkappaB and a disease cancer in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type... | A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population. | Proinflammatory cytokine gene polymorphisms have been demonstrated to associate with gastric cancer risk, of which IL1B-31T/C and -511C/T changes have been well investigated due to the possibility that they may alter the IL1B transcription. The signal transduction target upon interleukin 1 beta (IL1beta) stimulation, t... | {
"name": "NFkappaB",
"type": "GeneOrGeneProduct"
} | {
"name": "cancer",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein IL1beta and a disease cancer in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each relation type ... | A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population. | Proinflammatory cytokine gene polymorphisms have been demonstrated to associate with gastric cancer risk, of which IL1B-31T/C and -511C/T changes have been well investigated due to the possibility that they may alter the IL1B transcription. The signal transduction target upon interleukin 1 beta (IL1beta) stimulation, t... | {
"name": "IL1beta",
"type": "GeneOrGeneProduct"
} | {
"name": "cancer",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein IL1beta and a gene or protein nuclear factor of kappa B in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.Th... | A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population. | Proinflammatory cytokine gene polymorphisms have been demonstrated to associate with gastric cancer risk, of which IL1B-31T/C and -511C/T changes have been well investigated due to the possibility that they may alter the IL1B transcription. The signal transduction target upon interleukin 1 beta (IL1beta) stimulation, t... | {
"name": "IL1beta",
"type": "GeneOrGeneProduct"
} | {
"name": "nuclear factor of kappa B",
"type": "GeneOrGeneProduct"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein IL1B and a disease gastric adenocarcinoma in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of each r... | A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population. | Proinflammatory cytokine gene polymorphisms have been demonstrated to associate with gastric cancer risk, of which IL1B-31T/C and -511C/T changes have been well investigated due to the possibility that they may alter the IL1B transcription. The signal transduction target upon interleukin 1 beta (IL1beta) stimulation, t... | {
"name": "IL1B",
"type": "GeneOrGeneProduct"
} | {
"name": "gastric adenocarcinoma",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Association |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a disease gastric adenocarcinoma and a variant T allele at -511 in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meanings of ea... | A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population. | Proinflammatory cytokine gene polymorphisms have been demonstrated to associate with gastric cancer risk, of which IL1B-31T/C and -511C/T changes have been well investigated due to the possibility that they may alter the IL1B transcription. The signal transduction target upon interleukin 1 beta (IL1beta) stimulation, t... | {
"name": "gastric adenocarcinoma",
"type": "DiseaseOrPhenotypicFeature"
} | {
"name": "T allele at -511",
"type": "SequenceVariant"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a variant C-to-T substitution at -31 and a disease gastric adenocarcinoma in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Association'], based only on the information provided in the text.The meani... | A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population. | Proinflammatory cytokine gene polymorphisms have been demonstrated to associate with gastric cancer risk, of which IL1B-31T/C and -511C/T changes have been well investigated due to the possibility that they may alter the IL1B transcription. The signal transduction target upon interleukin 1 beta (IL1beta) stimulation, t... | {
"name": "C-to-T substitution at -31",
"type": "SequenceVariant"
} | {
"name": "gastric adenocarcinoma",
"type": "DiseaseOrPhenotypicFeature"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a chemical cisplatin and a chemical CAA in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association'], based only on the information pr... | Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy. | Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO. Depletion of sulfhydryl (SH) groups has been reported from cell culture, animal and clinical studies. In this work the effect of CAA on human proximal tubu... | {
"name": "cisplatin",
"type": "ChemicalEntity"
} | {
"name": "CAA",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Drug_Interaction",
"Cotreatment",
"Conversion",
"Comparison",
"Association"
] | Negative_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein caspase-8 and a chemical cisplatin in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of each r... | Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy. | Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO. Depletion of sulfhydryl (SH) groups has been reported from cell culture, animal and clinical studies. In this work the effect of CAA on human proximal tubu... | {
"name": "caspase-8",
"type": "GeneOrGeneProduct"
} | {
"name": "cisplatin",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Positive_Correlation |
<s>[INST]<<SYS>>
Your task is to determine the relationship between a gene or protein caspase-3 and a chemical cisplatin in a medical text. Choose the correct relation from ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'], based only on the information provided in the text.The meanings of each r... | Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy. | Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO. Depletion of sulfhydryl (SH) groups has been reported from cell culture, animal and clinical studies. In this work the effect of CAA on human proximal tubu... | {
"name": "caspase-3",
"type": "GeneOrGeneProduct"
} | {
"name": "cisplatin",
"type": "ChemicalEntity"
} | [
"Positive_Correlation",
"Negative_Correlation",
"Bind",
"Association"
] | Positive_Correlation |
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