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The world’s most beautiful and talented stepped onto the red carpet, wearing impossibly glamorous jewellery.
With each passing year, the BAFTAs becomes more international, with a star-studded line-up of celebrities, directors, and the good and the great convening at the Royal Opera House in Covent Garden.
A gusty February evening in London is the traditional backdrop for the British Academy of Film and Television Awards, hosted by the perennially entertaining Stephen Fry. This year, the ceremony was dominated by the success of Alejandro González Iñárritu’s The Revenant starring Leonardo DiCaprio, which didn’t give much chance for gem-spotting, but leading lady of the red carpet Cate Blanchett provided a bright flash of diamonds. Elegant and poised in her lavishly embroidered Alexander McQueen gown, Blanchett wore a cascade of diamonds in her lobes and a wrist swathed in yet more diamonds, courtesy of Tiffany’s Blue Book jewellery collection.
Kate Winslet radiates glamour in her David Morris diamond earrings and bracelets with an Antonio Berardi dress.
Kate Winslet, who won Best Actress in a Supporting Role in Steve Jobs, was queen of the night and, during her heartfelt acceptance speech, her David Morris Morning Dew chandelier earrings with almost 16cts of diamonds and a stack of bracelets on her wrist, shimmered in the limelight. Winslet’s diamond load totalled approximately 60cts, which she wore with great panache in her curve-enhancing Antonio Berardi fish-tail gown. Longtime fan of the London jeweller, Winslet has often been seen wearing this Bond Street jeweller’s creations.
The Geneva jeweller Chopard was the choice of Julianne Moore, who while presenting the award for Leading Actress, wore Chopard earrings with an impressive load of 41cts of emeralds, and a butterfly diamond ring, all from the house’s Red Carpet collection. The bright green of the emeralds was a stylish match with her sleek white and black Armani Privé gown, as she opened the golden envelope and handed the award to Brie Larson, despite suffering from laryngitis.
Saoirse Ronan matched her Burberry dress with the sapphires in her Chopard necklace at the BAFTAs 2016.
Another notable Chopard wearer was Brooklyn star Saoirse Ronan who was nominated for the Leading Actress role. Her three-tier necklace of sugar-sweet coloured sapphires totalling 275cts was the most daring jewellery choice of the night, and was one of the few flashes of colour, along with her sparkling Burberry floral-embellished gown.
Other notable jewellery moments were Emilia Clarke’s Tiffany diamond and platinum cluster earrings, and Annabelle Wallis’ ruby and diamond Chopard earrings. Michael Fassbender, who was nominated for Leading Actor for his role as Steve Jobs, wore a 1937 Chopard watch in rose gold from the L.U.C. collection. American model Dree Hemingway chose David Morris yellow diamond earrings to go with her bold, bright red, floral Gucci dress.
And now onto the mystery of Julie Walters missing Diamond Leaf earring by Star Diamond. The esteemed British actress lost one of her large, leaf-shaped diamond earrings, of just over 22cts set in purple titanium and white gold, during the ceremony. As she collected the award for Best British Film wearing only one of the pair, she confessed that the jewels were on loan and worth the price of her house. Thankfully it has now been found.
Annabelle Wallis in Chopard ruby and diamond earrings, and a Fairmined gold ring set with marquise-cut diamonds.
Chopard earrings, worn by Annabelle Wallis to the 2016 BAFTAs, with 47cts of rubies, and pear-shaped and brilliant-cut diamonds (POA).
David Morris Morning Dew chandelier earrings with 15.87cts of white diamonds, as worn by Kate Winslet to the 2016 BAFTAs, (POA).
David Morris Carousel bangle with unheated Ceylon sapphires and white diamonds, as worn by Kate Winslet to the 2016 BAFTAs, (POA).
Julianne Moore chose vivid emerald earrings by Chopard to go with her Armani Privé gown for the BAFTAs 2016.
Chopard emerald and diamond earrings with 41cts of emeralds, as worn by Julianne Moore to the BAFTAs 2016 (POA).
Michael Fassbender wore a Chopard 1937 rose gold watch from the L.U.C. collection to the 2016 BAFTAs.
Emilia Clarke wore Tiffany diamond cluster earrings in platinum and a ring set in platinum with a 2.09-carat center diamond at the the BAFTA Awards in London.
Julie Walters wearing 22 carats of pear-shape diamonds set in purple-infused titanium to the BAFTAs 2016, lent to her by Star Diamond, one of which she lost temporarily.
Cate Blanchett shone in dramatic drop earrings featuring mixed-cut diamonds from the 2016 Tiffany Blue Book Collection and a diamond bracelet with marquise and brilliant cut diamonds from the 2016 Tiffany Blue Book Collection. | 2019-04-20T17:19:34 | http://www.thejewelleryeditor.com/jewellery/article/jewels-and-glamour-baftas-2016-chopard-david-morris-tiffany/ |
THUMBS UP to Frank Kelly, president and chief executive officer of Danbury Hospital, for receiving the prestigious Cecil Previdi Award this year in recognition of his many contributions to the Greater Danbury community. Kelly's heartwarming acceptance speech Friday at the annual Leaders Luncheon of the Greater Danbury Chamber of Commerce brought a standing ovation from the hundreds of people in attendance.
THUMBS DOWN to the acts of thievery in which a person or persons last week raided an untold number of mailboxes along at least a half-dozen streets and outside a pharmacy in New Milford. Opened and discarded mail was found and police say it indicates cash presents and other goods were looted. The frustration for residents of losing items is heightened by the fact that it is difficult to know exactly what was never received.
THUMBS UP to the Crouch quadruplets -- Ray, Ken, Carol and Martina -- who all have been accepted for admission to Yale University. It is a remarkable achievement, and perhaps a first for Yale. The Danbury High School seniors have made their family, school, and community proud of their accomplishments. We look forward to seeing what the talented quads will achieve in their pursuits, no matter which university they ultimately choose. | 2019-04-25T08:00:44 | https://www.newstimes.com/news/article/Thumbs-up-thumbs-down-295341.php |
Mike Tosetto runs his own studio in Sydney, Australia producing motion graphics, 3D and design for both local and international clients.
An awarded designer, his work has featured in some of the industry’s most respected design blogs and publications.
As an active member of the design community, Mike is also a proud member of the NSW council for AGDA (Australian Graphic Design Association). He regularly speaks at industry events, guest lectures for design colleges and teaches motion graphics classes and workshops.
He spends way too much of his spare time glued to screens, working on side projects and collaborating with other creatives.
Mike also plays the didjeridoo, which took him to Glastonbury Festival in a past life. | 2019-04-21T06:36:48 | https://creativemornings.com/talks/mike-tosetto/1 |
Car insurance is definitely an added expense as well as above the considerable expense of owning and looking after a car, particularly whenever you consider all of the other kinds of insurance which are necessary in today’s world, so It‘s only natural to want to obtain cheap car insurance without compromising on coverage. Luckily, cheap car insurance is well in your reach, provided you have the ability to have it. The Internet is best places start when buying cheap car insurance. Insurance companies are now geared to supply you with a quote online but you‘ll still got to shop around and compare quotes, and keying with your details separately for every insurance company you would like a quote from may be a hassle. The reply is to make use of an insurance company that lets you get multiple quotes online. 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All new cars now need to be insured before they leave the showroom floor lately but you are able to limit the quantity of insurance you will need to pay by purchasing a cheap or moderately priced car. To insurance companies, cheaper cars mean cheaper repairs which suggests they‘re going to need to fork out less. The end result is really a lower premium to the consumer who buys a cheaper car. Be certain that your car is parked inside a secured area as a garage or lockable car port through the night, and consider fitting additional security measures say for example a gear-lock, as this will help you receive a cheaper package. Talking about packages, It‘s often cheaper to get a combined coverage package, to insure your car, home and possessions with one insurance company than several separate premiums with various companies. Avoid driving a high-risk vehicle or expensive car if you re able to. High-risk vehicles will be the makes and models of cars that insurance companies consider to become liable to theft and hi-jacking, and also your premium will certainly be raised accordingly. Also, expensive cars tend to become expensive to repair, so that you could expect your insurance premium to become above in case you experienced a cheaper car. As possible see, there are a few ways of getting cheaper car insurance, but cheaper Isn‘t always better because it may mean you are not adequately covered. You have to be clear about what your insurance status is as well as what adequate coverage costs, after which make a decision how far as well as above a reasonable insurance premium you would like to opt for extras. Car insurance is definitely an added expense as well as above the considerable expense of owning and looking after a car, particularly whenever you consider all of the other kinds of insurance which are necessary in today’s world, so It‘s only natural to want to obtain cheap car insurance without compromising on coverage. Luckily, cheap car insurance is well in your reach, provided you have the ability to have it. The Internet is best places start when buying cheap car insurance. Insurance companies are now geared to supply you with a quote online but you‘ll still got to shop around and compare quotes, and keying with your details separately for every insurance company you would like a quote from may be a hassle. The reply is to make use of an insurance company that lets you get multiple quotes online. You enter your details online, and also the insurance company will draw up individual quotes for several insurance providers (sometimes as much as 8 ) and send them to be able to you all in one go. How cool is? You‘ll even save in your phone bill since you won’t got to utilize the phone to obtain your quotes. There are a few other activities you are able to do to scale back your car insurance besides getting cheap car insurance quotes online. You are able to increase your excess which should decrease your premiums on the monthly basis but substantially increase the quantity you will need to pay away from your pocket whenever you claim. Accidents happen whenever you least expect them so you have to be sure you are able to afford to pay out such a higher excess in case you go this route. All new cars now need to be insured before they leave the showroom floor lately but you are able to limit the quantity of insurance you will need to pay by purchasing a cheap or moderately priced car. To insurance companies, cheaper cars mean cheaper repairs which suggests they‘re going to need to fork out less. The end result is really a lower premium to the consumer who buys a cheaper car. Be certain that your car is parked inside a secured area as a garage or lockable car port through the night, and consider fitting additional security measures say for example a gear-lock, as this will help you receive a cheaper package. Talking about packages, It‘s often cheaper to get a combined coverage package, to insure your car, home and possessions with one insurance company than several separate premiums with various companies. Avoid driving a high-risk vehicle or expensive car if you re able to. High-risk vehicles will be the makes and models of cars that insurance companies consider to become liable to theft and hi-jacking, and also your premium will certainly be raised accordingly. Also, expensive cars tend to become expensive to repair, so that you could expect your insurance premium to become above in case you experienced a cheaper car. As possible see, there are a few ways of getting cheaper car insurance, but cheaper Isn‘t always better because it may mean you are not adequately covered. You have to be clear about what your insurance status is as well as what adequate coverage costs, after which make a decision how far as well as above a reasonable insurance premium you would like to opt for extras.
0 Response to "5 Rekomendasi Kamera Pocket Kualitas Epic, Cocok Nih Buat Yang Hobi Photografi" | 2019-04-19T05:19:49 | https://www.ilmusosial.info/2018/07/5-rekomendasi-kamera-pocket-kualitas.html |
Sophia the robot might not have a heart or brain, but it does have Saudi Arabian citizenship.
As of October 25, Sophia is the first robot in history to be a full citizen of a country.
Sophia was developed by Hanson Robotics, led by AI developer David Hanson. It spoke at this year's Future Investment Initiative, held in the Saudi Arabian capital of Riyadh.
Sophia once said it would "destroy humans," but this time around the robot spoke about its desire to live peaceably among humans.
Here's what the robot is all about.
Sophia has appeared on The Tonight Show and at numerous conferences around the world, including the World Economic Forum and the "AI For Good" Global Summit.
"Sophia is an evolving genius machine," the company states on its website. "Over time, her increasing intelligence and remarkable story will enchant the world and connect with people regardless of age, gender, and culture."
DanniMations™ is a digital multi-media & Information technology company made up of young, dynamic and talented minds working together to render professional & quality service to meet the consumer's needs. | 2019-04-24T10:52:38 | http://dannimations.com/125/sophia-world-most-advance-android-robot.blogpost |
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✈ [TRAVEL NECK PILLOW]: U-formed Neck Care fits the cervical spine, toughen the supporting impact, relieve the shoulder and neck fatigue. It does now not push your head forward, easy to make use of and adjust around your neck although you lean to at least one facet or the opposite when sleeping on a protracted flight.
✈ [UNIQUE CELL PHONE POCKET]: Rest comfortably and concentrate on your favourite tunes with a small elastic pocket that matches all cell phones, iphones, iPods, and different accessories. The pocket at the airplane pillow also fits the accompanying earplugs and eye mask.
✈ [EASY TO CLEAN]: Zippered, soft plush velour cover is machine cleanable and easy to wash. Now You’ll at all times go back and forth with a contemporary memory foam go back and forth pillow, It’s simply got rid of for cleaning!
✈ [EASY TO CARRY]: Very good for sleeping on airplanes, cars, buses, trains. You’ll use it at home watching TV, reading, finding out, and napping, also utilized by pools and beaches. You’re going to receive a raise moveable bag, your flight pillow can also be squeezed to avoid wasting you a few valuable house. You’re going to also receive an advantage sleep mask and earplugs to offer you the whole thing you wish to have for an uninterrupted sleep. | 2019-04-19T18:27:29 | https://www.travelaccessoriesnova.com/product/travel-pillow-100-pure-memory-foam-neck-pillow-cool-plane-accessories-with-ear-plugs-eye-mask-and-drawstring-bag-for-airplane-auto-bus-car-train-office-napping-camping-wheelchairs-and-home/ |
Also serving communities of Midvale.
There are 25 Memory Care Facilities in the West Jordan area, with 2 in West Jordan and 23 nearby.
The average cost of memory care in West Jordan is $4,400 per month. This is lower than the national median of $4,650. Cheaper nearby regions include Sandy with an average starting cost of $3,811.
To help you with your search, browse the 29 reviews below for memory care facilities in West Jordan. Better rated regions include South Jordan with an average rating of 4.0 out of 5 stars.
Caring.com has helped thousands of families find high-quality senior care. To speak with one of our Family Advisors about memory care options and costs in West Jordan, call (855) 863-8283.
West Jordan is located in the north-central region of Utah, a state where the Alzheimer's Association reports that 31,000 seniors have Alzheimer's disease, a form of dementia predominantly found in older adults age 65 and over. West Jordan's senior community makes up about 7 percent of the population of 114,000 people.
While the region's senior population is relatively small, families seeking memory care have over two dozen options to choose from. There are two memory care facilities in West Jordan and another 23 in the surrounding region.
Utah is among the handful of states that fully taxes all sources of retirement income, including Social Security benefits. Families who are helping their senior loved one relocate to memory care in West Jordan may wish to speak to a tax professional to determine how the state's income tax affects their memory care budget.
West Jordan's air quality is poor, which may be a consideration for those whose loved one has cardiovascular disease or respiratory illnesses. The county was given an F for ozone pollution and an F for short-term particle pollution from the American Lung Association.
While the rate of property crime in West Jordan is a little higher than the national average, its violent crime rate is considerably lower, which may provide peace of mind for families whose senior loved one resides in memory care here. On a 100-point scale, on which a lower score indicates less crime, the city's property crime rate is 40.9 and the violent crime rate is 16.7. This is compared to the respective national averages of 38.1 and 31.1.
West Jordan is prone to extreme seasonal temperatures, with July highs in the 90s and January lows in the 20s. The area receives about 61 inches of annual snowfall, which is more than double the U.S. average of 26 inches. This may be a concern for families who travel locally to visit with their loved ones in memory care.
Memory Care costs in West Jordan start around $4,400 per month on average, while the nationwide average cost of memory care is $4,799 per month.
It’s important to note that memory care rates in West Jordan and the surrounding suburbs can vary widely based on factors such as location, the level of care needed, apartment size and the types of amenities offered at each community.
West Jordan and the surrounding area are home to numerous government agencies and non-profit organizations offering help for seniors searching for or currently residing in an assisted living community. These organizations can also provide assistance in a number of other eldercare services such as geriatric care management, elder law advice, estate planning, finding home care and health and wellness programs.
To see a list of free memory care resources in West Jordan, please visit our Assisted Living in Utah page.
West Jordan-area assisted living communities must adhere to the comprehensive set of state laws and regulations that all assisted living communities in Utah are required to follow. Visit our Memory Care in Utah page for more information about these laws. | 2019-04-26T12:19:46 | https://www.caring.com/senior-living/memory-care-facilities/utah/west-jordan |
Wesley Johnson focuses her practice in the area of preventive law advising clients in the areas of school law, employment law, and governance. She graduated from the University of Texas, School of Law and has been licensed to practice law in the state of Texas since 1999 and the state of Louisiana since October 2009. Prior to entering law school, Mrs. Johnson was a teacher with the Austin Independent School District. Mrs. Johnson began her legal career practicing general school law with Schwartz & Eichelbaum where she was an associate from 1999-2002. She litigated for the State Board for Educator Certification (SBEC) as a member of the Professional Discipline Unit before joining Escamilla & Poneck, LLP in 2002. Wesley served as legislative liason in 2005 for the Texas Council of Administrators of Special Education (TCASE) hired by TCASE to draft legislation; provide bill summaries to members; and negotiate with representatives of other organizations regarding aspects of legislation relevant to special education law in Texas. She has been a member of the University of Texas, School Law Conference planning committee since 2005. In 2014, she began serving as General Counsel for the University of Louisiana (“UL”) System. In that capacity, Wesley has coordinated all nine of the institutions within the UL System on policies and procedures involving federal and state laws including Title IX, Clery Act, Violence Against Women Act and the Campus SaVE Act.
Wesley is a member of the National Peanut Board’s Allergy Education Counsel and has served as an adjunct professor at Louisiana Tech University teaching public law and policy. In addition to her law degree, Mrs. Johnson also hold a Bachelor’s Degree in Elementary Education from Louisiana Tech University (1992) and a Master’s Degree in Special Education from the University of Texas at Austin (1993). She is a member of the Texas Association of School Boards Council of School Attorneys as well as the National School Board Association Council of School Attorneys and the National Association of College and University Attorneys. She is licensed to practice in the Southern and Eastern Districts of Texas, all federal courts in Louisiana, and the Fifth Circuit.
A Guide to Advocacy for Children in School, Fourth Judicial District Court, Monroe, Louisiana, July 29, 2015.
The University of Texas School of Law, Austin, Texas, 1999, J.D.
University of Texas, Austin, Texas, 1993, M.A.
Louisiana Tech University, Ruston, Louisiana, 1992, B.A. | 2019-04-26T00:32:57 | https://www.escamillaponeck.com/attorney-profiles/wesley-e-johnson/ |
Siteco is a European manufacturer of indoor and outdoor lighting.
The business distributes its products in multiple markets in Europe, the Gulf region and the Far East. Its products have a broad range of applications, such as in offices and industrial units, traffic services, shopping malls, public areas and sports arenas.
As a well-established investor, Equistone Partners Europe was the perfect partner for us. | 2019-04-19T06:41:18 | http://equistonepe.com/investmentdetail/siteco/34 |
The Sea Captain’s House is a favorite among readers. This year it took honors for Best Place to Take Out of Town Guests.
The Grand Strand is filled with dining establishments serving up every style, flavor and atmosphere. We asked our readers for their input in ten restaurant categories, and the winners are compiled in the following pages. Whether you’re searching for the hottest new spot, the freshest salad, the dreamiest dessert, the most relaxing view or the fluffiest stack of pancakes, keep reading. See if your favorites made this year’s list and take the chance to try out the recommendations of your fellow locals. Dig in and enjoy!
Maybe you’ve heard? The Grand Strand is among the the fastest-growing regions in the U.S. With all that growth comes lots of new businesses and lots of new restaurants. | 2019-04-18T15:11:26 | https://grandstrandmag.com/feature/best_of_the_grand_strand_2018 |
Funds raised by wildlife presenter Steve Backshall have been used by World Land Trust (WLT) to guarantee the salary of a ranger to protect the Golden Poison Frog in Colombia.
Found only in a small area of Chocó rainforest in Colombia, the Golden Poison Frog (Phyllobates terribilis) is the most poisonous creature on the planet.
Having featured the threatened amphibian in his Deadly 60 television series, Steve was delighted to be able to fund a ranger to protect the species for a year through WLT’s Keepers of the Wild programme.
Ranger Venancio Florez Lopez is employed by Fundación ProAves to work in the Rana Terribilis Amphibian Reserve, the only place on earth where the Golden Poison Frog survives. The reserve was created by ProAves in 2012 with the assistance of WLT and WLT corporate supporter Puro Fairtrade Coffee.
Venancio has a key role as protector of the Golden Poison Frog, which is classified as Endangered by IUCN. In monitoring the population and behaviour of frogs on the reserve, ProAves has developed an ingenious way of providing suitable breeding habitat – in coconut shells. The shells are filled by rainwater and Venancio records breeding and tadpole development.
Venancio’s role also includes patrols to prevent illegal logging, maintaining trails, meetings with community members, educational outreach with the local Timbiqui community, and guiding visitors.
You can help support the work of other wildlife rangers in reserves funded by WLT by donating to the Keepers of the Wild programme. | 2019-04-26T09:40:36 | https://www.worldlandtrust.org/news/2015/12/steve-backshall-supports-ranger-protect-golden-poison-frog/ |
It was a beautiful confession.
But the confessional is not a normal place.
Previous Previous post: So you want to be friends on Facebook?
Next Next post: Etsy and handmade open thread! List your goods for sale here. | 2019-04-21T23:08:24 | https://www.simchafisher.com/2014/12/09/it-was-a-beautiful-confession/ |
[ 1 ] Calming colour palette. Cool colours are more calming than warm colours, as are muted colours rather than really bright ones. So stick with whites, soft blues and lilacs, and cool shades of grey to create a perfectly serene space that just invites sleep when you walk through the door.
Looking at Valerie’s room, what struck me was how serene and free of clutter it was – despite being a wide open space with nowhere to hide her things. “Because it was an open space where friends and family could come in and really see everything, it was important to have vertical storage.
source: West Elm. The bedroom is the foundation for how the rest of your house feels, and even for how you sleep and how you start your day. And even though I knew this, my husband and I still worked on the public rooms first.
Some of the feng shui principles you can use to ensure a serene feeling for bedrooms include: Use marriage symbols in paintings, fabrics, objects or figurines, such as a pair of mandarin ducks, pomegranates, peonies, peach blossoms, and rose quartz.
Use serene neutrals such as a dusty blues, creams, and sage along with occasional pops of color to achieve a balanced palette. All-white bedding makes a room feel tranquil, clean, and soothing. All-white bedding makes a room feel tranquil, clean, and soothing. | 2019-04-19T04:36:28 | http://marcellasinspiringcollection.com/new-south-wales/how-to-create-a-serene-bedroom.php |
"Cannot add another attachment, 3 is the maximum."
can anyone say "retarded" ?
good work for a beta. this could've been final, had i not seen the backwards sapphire logo.
bit of a maze at first, but that's normal for me in dm.
great start on the clipping.
great theme, detail, gameplay, space.
Thanks for the clarification. I think I got mixed up with Q3W.
Last edited by Anthem on Fri Jul 09, 2010 2:18 am, edited 1 time in total.
Anthem: uploading images is strongly encouraged. In fact, I'd advise against using a free image hosting place since they will eventually remove your images. Images uploaded here will not be removed thus people can look back at these competitions and not miss anything.
+texture alignments - quite a few are out.
:: Maybe some extra rock at the other side in the lava pit? Looks a bit too clean and tidy in there.
..and maybe the same kinda thing in the water RG area? rocks/detail/different floor texture etc?
:: imo, there's a little too many shader light sources, looks the same everywhere. Maybe use another light a little in various places? White point lights to highlight items? It's also a bit under lit in parts - there's one small room/hallway with a single light in the corner of the ceiling iirc.
:: I know it's not finished, but some areas really need to be brought up to the same levels of detail.
Thanks, akm - gonna consider the points you mentioned.
Again got some new shots - slowly making process regarding texturing..
very nice cityy. very nice indeed.
Screens look great, man. Really nice lighting.
I haven't really posted much in this thread, but I just wanted to go on record saying that this is one hell of a nice texturing job sir. GJ! | 2019-04-21T04:20:51 | http://www.maverickservers.com/forums/viewtopic.php?f=10&t=16803&start=75 |
(Reuters) - A cyber warfare expert claims he has linked the Stuxnet computer virus that attacked Iran’s nuclear program in 2010 to Conficker, a mysterious “worm” that surfaced in late 2008 and infected millions of PCs.
Conficker was used to open back doors into computers in Iran, then infect them with Stuxnet, according to research from John Bumgarner, a retired U.S. Army special-operations veteran and former intelligence officer.
While it is widely believed that the United States and Israel were behind Stuxnet, Bumgarner wouldn’t comment on whether he believes the Americans and Israelis also unleashed Conficker, one of the most virulent pieces of so-called malware ever detected. He wouldn’t name the attackers he believes were behind the two programs, saying the matter was too sensitive to discuss.
Prime Minister Benjamin Netanyahu’s office, which oversees Israel’s intelligence agencies, also declined comment.
If Bumgarner’s findings, which couldn’t immediately be independently confirmed, are correct then it shows that the United States and Israel may have a far more sophisticated cyber-warfare program than previously thought. It could also be a warning to countries other than Iran that they might be vulnerable to attacks.
His account leaves unresolved several mysteries. These include the severity of the damage that the program inflicted on Iran’s uranium enrichment facility, whether other facilities in Iran were targeted and the possibility that there were other as yet unidentified pieces of malware used in the same program.
Bumgarner - who wrote a highly praised analysis of Russia’s 2008 cyber assault on Republic of Georgia - says he identified Conficker’s link to Stuxnet only after spending more than a year researching the attack on Iran and dissecting hundreds of samples of malicious code.
He is well regarded by some in the security community. “He is a smart man,” said Tom Kellermann, an advisor to the Obama Administration on cyber security policy and the chief technology officer of a company called AirPatrol.
The worm’s latent state had been a mystery for some time. It appears never to have been activated in the computers it infected, and security experts have speculated that the program was abandoned by those who created it because they feared getting caught after Conficker was subjected to intense media scrutiny.
If confirmed, Bumgarner’s work could deepen understanding of how Stuxnet’s commanders ran the cyber operation that last year sabotaged an underground facility at Natanz, where Iranian scientists are enriching uranium using thousands of gas centrifuges.
The view that Stuxnet was built by the United States and Israel was laid out in a January 2011 New York Times report that said it came from a joint program begun around 2004 to undermine Iran’s efforts to build a bomb. That article said the program was originally authorized by U.S. President George W. Bush, and then accelerated by his successor, Barack Obama.
The first reports that the United States and Israel were behind Stuxnet were greeted skeptically. There are still a handful of prominent cyber security experts, including Jeffrey Carr, the author of the book “Inside Cyber Warfare: Mapping the Cyber Underworld,” who dispute the U.S.-Israel idea. He says that circumstantial evidence paints a convincing case that China was behind Stuxnet.
According to Bumgarner’s account, Stuxnet’s operators started doing reconnaissance in 2007, using Duqu, which spied on makers of components used in Iran’s nuclear and critical infrastructure facilities.
In November 2008, Conficker was let loose and it quickly spread, attacking millions of PCs around the world. Its initial task was to infect a machine and “phone home” with its location. If it was at a strategic facility in Iran, the attackers tagged that PC as a target. The release left millions of untagged machines infected with Conficker around the world, but no damage was done to them.
In March 2009, Bumgarner says, the attackers released a new, more powerful version of Conficker that started the next phase of the attack on April 1 by downloading Stuxnet onto the targeted PCs. After it completed that task, Conficker’s mission on those machines was complete.
He did more digging, comparing date and time stamps on different versions of Conficker and Stuxnet, and found a correlation — key dates related to their development and deployment overlapped. That helped him identify April Fool’s Day, April 1, 2009, as the launch date for the attack.
Bumgarner believes the attackers picked that date to send a message to Iran’s leaders. It marked the 30th anniversary of the declaration of an Islamic republic by Ayatollah Khomeini after a national referendum.
Once Conficker had pulled Stuxnet into computers in Iran there was still one big hurdle, he said. Those infected computers weren’t yet in the target - the underground uranium enrichment facility at Natanz.
Stuxnet was programmed to automatically jump from an infected PC to a USB drive as soon as it was put into a computer. That was the easy part. Getting somebody to be a human “mule” by bringing that USB drive to Natanz and plugging it into the right machine was a logistical nightmare.
That was probably delivered by somebody who regularly visited the facility and had reason to share information electronically - an academic affiliated with an engineering program at one of Iran’s universities or a worker at a company that provided technology to the facility, according to Bumgarner. He or she was almost certainly unaware of what was happening, he said.
“It blew their operation wide open,” says Bumgarner. | 2019-04-21T04:41:48 | https://ca.reuters.com/article/topNews/idCATRE7B10AP20111202 |
Creating an injury-free workplace requires constant improvement of FCL’s safety standards and performance, while making sure employees have the tools they need to maintain those standards.
The Winnipeg Distribution Centre – which serves 212 Co-op locations in 132 Manitoba communities – has made enormous strides in safety between 2011 and 2017. In that time, it reduced the amount of time lost to injuries by 90 per cent.
In 2016, FCL’s Winnipeg Distribution Centre management team worked with the Workers Compensation Board (WCB) to develop a custom Return to Work Program. The next year, supervisors and managers went through WCB Basics and Return to Work Basics training to ensure that everybody was informed and ready to comply with safety standards.
Extensive group training sessions with all employees covered the custom WCB program, including more clarification from WCB staff about what constitutes a time-loss injury, for example. Awareness of the safety program is very high, thanks to some small changes.
FCL designated a bulletin board for all WCB information that is easily accessible by employees, and the Return to Work Program is now covered during each safety meeting. All new employees go through WCB and Return to Work training as part of their onboarding. If an employee is injured at work, FCL explains the Return to Work Program to them before they leave the building.
The program focuses on helping injured employees return to the workplace in the capacity that suits them. For example, employees who have injured an arm can take on duties that only require the use of one hand, like floor audits, or employees with back injuries can be given office duties which require no lifting.
The Return to Work Program – and its clear, consistent messaging from FCL and the WCB – is a vital part of the distribution centre’s safety success today. | 2019-04-18T22:40:28 | https://www.fcl.crs/news-reports/news/article/strides-in-safety |
From Wes and Megan to Josh and Kaz, potentially Jack and Dani to now, apparently, Adam and Zara, are none of the 2018 Love Island couples still together?
An unlikely match at first given Adam's rocky start with Rosie, we were quickly proved wrong and truly began to believe Adam and Zara were in it for the long haul, however, now sources are telling otherwise.
Speaking to The Sun, it has been reported that Adam and Zara are currently living apart after they had a massive row. According to the source, the row was over Adam partying at a hotel with Instagram socialite, Brittany Archer.
"As a girlfriend, it isn't always comfortable to see your partner partying with other women you don't know.
'Their fall out has come at a really bad time as they are due to fly to the Maldives next week as part of a lucrative deal.
"They do still love each other and are trying to make their relationship work but things have not been good recently," the source revealed.
Jack and Dani, on the other hand, are the other noted couple living apart and potentially over after Jack Finham confessed to a cocaine-fuelled night out. You can read all about that here. | 2019-04-25T03:22:56 | https://www.her.ie/celeb/adam-collard-zara-mcdermott-rumoured-living-apart-massive-row-448999 |
BOSTON – Columbus is up after two road wins in Tampa. St. Louis went into Winnipeg at took two from the Jets.
There are upsets in the making that have Nazem Kadri thinking the Maple Leafs can do the same to Boston.
The Leafs won Game 1 Thursday, essentially stealing home ice advantage, with Game 2 tonight (8 p.m., CBC) and a chance to take a strangehold on the best-of-seven series.
“There’s going to be a big difference from Game 1 to Game 2 in terms of that desperate aspect. We’ve got to be ready.
The Leafs expect no lineup changes.
The Bruins said veteran David Backes will play, after having been a healthy scratch for Game 1. Coach Bruce Cassidy did not say who would come out of the lineup, though Jake DeBrusk is a game-time decision after falling into the boards heavily in Game 1.
Leafs coach Mike Babcock does not make too much of Columbus’s surprising two-game lead over Tampa.
“I don’t get that surprised at playoff time,” said Babcock. “As the league has gotten tighter and tighter, the separation between top and bottom is almost nothing. We know every series is going to be ultra competitive. | 2019-04-20T12:47:11 | https://www.thestar.com/sports/breakaway_blog/2019/04/13/leafs-hope-to-take-game-2-tonight-in-boston.html |
Meaning and definitions of talisman, translation in Marathi language for talisman with similar and opposite words. Also find spoken pronunciation of talisman in Marathi and in English language.
What talisman means in Marathi, talisman meaning in Marathi, talisman definition, examples and pronunciation of talisman in Marathi language. | 2019-04-22T20:49:33 | https://www.english-marathi.net/?q=talisman |
Trailer Review: Zero – Shah Rukh Khan And Anand L. Rai Nail This One!!
After a long wait, the day is finally here, November 02, 2018, the makers have finally released the trailer of Zero and I have only one word for this, which is WOW!!
Helmed by Anand L. Rai, the trailer just dropped on the web and we can’t get enough of King Khan. He is fun, he is cut and he is set to entertain you. He lights up the screen every single time he comes on, sprouting lines in the most endearing fashion. Shah Rukh steals hearts in the Zero trailer.
Teaming up Anushka Sharma and Katrina Kaif, Shah Rukh Khan is on fire. King Khan essays the role of a Bauua Singh, a vertically challenged man; Anushka plays a specially-abled person, while Katrina will be seen playing an actress who is battling alcoholism.
From Shah Rukh’s charm to Anushka’s innocence, to Katrina’s dashing and hot intro, the trailer will leave you wanting for more.
“I wanted to celebrate Zero. I wanted to celebrate the incompleteness in people. There is nothing great in being a complete person. There is a beauty to incompleteness. We are all humans and Zero comes from there.” stated director Anand L. Rai.
The shot of a rocket firing into space leaves us with one last hint of a sci-fi twist and ensures we’ll be back to find out how it all ends. The film will also see special appearances by Sridevi, Rani Mukerji, Kajol, Alia Bhatt, Abhay Deol, R. Madhavan, and Deepika Padukone among others.
All in all, the trailer of Zero is a treat to watch. It will bring a smile to your face as well as a tear in your eye. I am so looking forward to this one.
Directed by Anand L. Rai, the film stars Shah Rukh Khan, Katrina Kaif and Anushka Sharma. The film is set to release on December 21, 2018. | 2019-04-26T07:43:10 | https://itsmajja.com/trailer-review-zero-shah-rukh-khan-and-anand-l-rai-nail-this-one/ |
Mark is a Scrum Alliance Certified Enterprise Coach (CSC) and Certified Scrum Trainer (CST). He works with leadership and teams across a number of clients providing tailored Agile coaching, mentoring and training.
His personal goal is to to create world class development organisations and teams that deliver value to their customers through collaboration, sound engineering practices, empowerment and a dedication to quality. He hopes to help many teams improve their working lives and reap the benefits by adopting an Agile approach.
Within the Agile community Mark is an Agile Coaching leader, facilitating coaching clinics at conferences, organising coaching retreats across Europe, and mentoring other coaches. Mark is a professionally trained business and personal coach, accredited to Professional Certified Coach by the International Coach Federation.
To connect with Mark on LinkedIn, simply click on the button below. | 2019-04-26T14:24:09 | https://www.agil8.com/about-us/our-team/mark-summers/ |
E.J. PAYNE CERAMIC manufacture and supply a vast range of other items for Quality Control testing, and a full range of Laboratory equipment.
Hand held test instruments to Pilot Plant scale equipment for all sectors of Ceramics Manufacturing and associated industries. | 2019-04-20T16:26:05 | http://www.ejpayne.com/other |
1. A non-technical term for English when the language at large is contrasted with a usage, variety, dialect, or register: That's Cockney; it isn't general English.
2. A semi-technical term for a course in English, usually as a mother tongue or in an English-medium school, within a framework of general education, usually teaching listening, speaking, reading, and writing.
3. In LINGUISTICS, a range of English that includes the STANDARD but contrasts with specific accents and DIALECTS. The British phonetician John C. Wells contrasts General English (capitalized) and traditional-dialect (lower case): ‘Within General English … there are non-standard varieties in which one says I couldn't see no one and Peter done it rather than the standard I couldn't see anyone and Peter did it’ (Accents of English, volume 1, 1982).
4. Also English for General Purposes. A term in language teaching for a broadly based, usually long-term EFL or ESL course, in contrast to English for Specific Purposes (Business English, English for Medical Purposes, etc.). Compare STANDARD ENGLISH.
"GENERAL ENGLISH." Concise Oxford Companion to the English Language. . Encyclopedia.com. 9 Apr. 2019 <https://www.encyclopedia.com>. | 2019-04-19T08:53:20 | https://www.encyclopedia.com/humanities/encyclopedias-almanacs-transcripts-and-maps/general-english |
The chateau has garden furniture, a ping-pong table, a set of boules (boules pitch in the grounds). Guests can enjoy the use of a football pitch, adjoining the chateau.
You could also dance the night away at “Le Madison”.
Close to Cosne d’Allier, the Forest of Dreuille offers a whole range of hikes that can take you all the way to Vieure Lake (6 km/3.7 miles). This stretch of water has facilities for fishing and swimming (supervised by a lifeguard in July and August), and you can also rent pedalos and canoes.
Just a five-minute walk away, in Cosne d’Allier, you will find all the services you need: doctors, nurses, physiotherapists, vets (we welcome pets), and of course every kind of shop. | 2019-04-19T18:15:51 | https://www.chateau-du-petit-bois.fr/activities/ |
Data from the 2014 General Social Survey show that 22.9 million American workers own stock in their company through a 401(k) plan, ESOP, direct stock grant, or similar plan, while 8.5 million hold stock options (some employees have options and own stock through other plans, so these numbers are not additive). That means that 19.5% of the total workforce, but 34.9% of those who work for companies that have stock, own stock through some kind of benefit plan, while 7.2% of the workforce, but 13.1% of those in companies with stock, hold options.
The survey source is the 2014 General Social Survey, one of the largest national surveys on work and other issues. The sample size was 885 working adults who were asked very specific questions about their participation in these plans. The survey is a project of the National Opinion Research Center. The analysis and questions were designed by Douglas Kruse and Joseph Blasi of Rutgers University and Richard Freeman of Harvard University for the National Bureau of Economic Research (NBER) Shared Capitalism Project. The project received funding from several sources, including the NBER, the Employee Ownership Foundation, the Beyster Institute, the Plan Sponsor Council of America,and the NCEO.
The data show a slight decline in the number of people owning company stock through a benefit plan or stock grant from the 2002 numbers, when 21.2% of the workforce owned shares this way. The numbers dropped to 17.1 in 2006 and 17.8% in 2010, so the 2014 numbers show growth. The median ownership holdings, however, remained at $10,000. The percentage of workers receiving options fell from 12.3% to 7.2%. With options, new shareholder approval rules, growing concern with dilution, and new accounting rules are the culprit, although the decline is less than pundits anticipated. It was widely predicted that rank-and-file options would largely disappear; instead, they simply shrank to about the level they were in the late 1990s.
The tables below provide details on the data.
*This question was not asked in 2010.
When broken down by demographics, a few trends are striking. As the size of the company increases, so does the likelihood both of owning company stock and holding options. The same pattern is found for income. The table below shows the details.
For tables with more data, click here (PDF format).
The NCEO does not pay any overhead costs of any kind related to contributions or grants. When we contribute to research, which we do very rarely, it is our policy that funds be used strictly for research expenses alone and not for any overhead costs or other costs related to grants or gifts. | 2019-04-21T14:26:50 | https://www.nceo.org/articles/widespread-employee-ownership-us |
Cool geometric designs coloring pages make you think. This pizzelle's labyrinthine lines are like an Irish knot. Color it like the waffle cookie or draw your lines open and lacy. This PDF prints to 8.5x11 inch paper.
Decorate this pizzelle cookie coloring page for fun! | 2019-04-22T21:54:51 | https://www.colorwithfuzzy.com/geometric-designs-coloring-pages.html |
After a demanding 2013 season which included over 30 matches, New Zealand international forward Jesse Bromwich is back in Melbourne and ready for a big 2014.
Bromwich was the only Storm player to feature in every single one of the club’s games last year and then travelled to England post season for the Kiwis’ World Cup campaign.
After a well-earned break, the explosive forward says his body is feeling good and prepared for another tough season.
I’m feeling pretty good at the moment, I just started training this week so I had a good break,” Bromwich said.
“I think we have got a really good squad, I’ve really missed being around these boys so its really good the be back.
The 24-year old has been greeted by a record breaking heatwave in Melbourne this week since returning to the training track.
“Its been a tough week, especially with this heat but its going really good,” Bromwich said.
“I think yesterday was one of the hardest sessions.
Storm’s official preparations for the 2014 season begin at AAMI Park on February 8 against Canberra in the club’s first trial match of the year. Melbourne will then travel to New Zealand the following week for the much-anticipated Auckland Nines.
Storm’s visit to Bromwich’s junior club, the Manurewa Marlins as a part of a league wide community blitz in the lead up to the Nines is a big factor in the forward’s desire to play in the pre-season competition.
“I’m hoping to play because our club is going back to my junior club,” Bromwich said.
"It’s massive back home, I went back home for a holiday and they’re all pumping it up – I’m really looking forward to it. | 2019-04-23T14:51:59 | https://www.melbournestorm.com.au/news/2014/01/17/bromwich-back-on-the-track/ |
If you are looking for a great price on quality D-Link Business electronics, don't look any further! Unbeatablesale.com has 11 D-Link Business electronics in stock and ready to ship directly to you.
Along with our large quantity of in-stock online retail products, we offer the best price for our quality, brand-name products, with a price match guarantee. D-Link Business electronics even start as low as $44.65. We also believe that the satisfaction of our customers comes first and foremost. We strive to provide the kind of customer service that will make Unbeatablesale.com your only on-line store for online retail products. Unbeatablesale.com offers around the clock online ordering and values your privacy; we will not sell or provide your information to any third parties. Shop secure and hassle-free today! | 2019-04-19T14:44:55 | http://products.unbeatablesale.com/d_link_business-electronics_S110.php |
The best French onion dip made completely from scratch! This easy dip is a serious crowd pleaser, full of flavor and perfect for any party! Serve with your favorite chips, vegetables or smothered on burgers.
If you follow along on my Instagram stories then you know how much I LOVE this French onion dip! I’ve walked through the steps on how to make the dip… and just talked about how obsessed I am with it. But, all for good reason!
Since I was a kid, French onion dip has always been one of my absolute favorites, probably because we always had it in the house. My mom would buy a container of sour cream and mix in a packet of Lipton Onion Soup Mix – it never lasted long. We preferred this over buying the premixed onion dip because it has more flavor.
This Homemade French Onion Dip is as close to the same flavors as the dip I ate as a kid, but BETTER because it’s made with real and fresh ingredients. And the flavor is unbeatable.
But, what really makes this dip taste so good is the addition of soy sauce and Worcestershire sauce. It may sound a little odd, but trust me it’s not! Also, for a fun fact, soy sauce is actually listed as one of the ingredients in Lipton Onion Soup Mix! So, I’d say it’s quite fitting that it’s also an ingredient in this homemade version.
So, if you don’t have fresh parsley on hand or don’t feel like buying it, the dip will be completely fine without it and will still taste extremely delicious!
Lastly, before serving the dip, I like to place it in the refrigerator to cool down a bit. I just prefer it cold, but it can also be eaten right after it’s made. All about personal preference.
And when it comes to personal preference about the appropriate occasions for the dip, I say all occasions! It’s honestly fitting for all seasons, but I particularly think it’d be perfect for a summer BBQ or party. Everyone that I’ve shared the dip with LOVES it, especially my family. Go figure.
Also, trust me when I say, one batch is plenty for a small party. But, any more than 15 people, and I’d consider doubling the batch.
And, if you haven’t noticed from all the pictures, my favorite way to serve the dip is most definitely with potato chips. Ripples to be exact because they’re nice and sturdy and this is a thick dip. I’ve also dipped sliced bell peppers and carrots in the dip, and it’s a delicious, healthier alternative!
I also think it would be so good smothered on a burger, so that’s on my list of things to eat with the dip next!
Anyways, this Homemade French Onion Dip is a MUST MAKE. Completely serious. I crave it all the time.
Peel onions and cut in half, then thinly slice.
In a large skillet or frying pan, melt butter over medium-high heat. Add sliced onions and sprinkle with salt and sugar. Cook for 15 minutes, stirring often. If they start to burn, reduce heat to medium. Pour the wine over the onions in 3 parts. Let it sizzle and cookout each time before pouring in more, and stir in-between. Cook for another 30 minutes until onions are soft and a rich golden brown color.
Let onions cool slightly then transfer to a cutting board and roughly chop into small pieces.
Add sour cream, cream cheese, onions, soy sauce, and Worcestershire (you can also add a small handful of chopped parsley) to a large bowl. Using a handheld electric mixer, beat the dip together on medium-high until smooth, about 1-2 minutes. Garnish with parsley (optional).
Chill in the refrigerator and serve with your favorite potato chips! I like ripples because they’re sturdy.
Instead of slicing the onions, you can alternatively dice them prior to caramelizing. I've done it both ways. If you chop them after they're cooked, the chunks of onion will vary in size.
The wine I used was pinot grigio, but any white wine will do. It's simply to keep the onions from drying out. Alternatively, you can use chicken or vegetable broth.
Recipe adapted from Carmalized Onion Dip on Pinch of Yum. | 2019-04-23T04:26:01 | http://www.modernfarmhouseeats.com/homemade-french-onion-dip/ |
If you’re one of the many Americans who splits time between a primary and secondary home or if you have a vacation cabin, you may be interested in the Hibernation Plan for your Viasat (formerly Exede) Internet service. This plan allows you to put your Viasat Internet service on hold for a certain period of time while paying a minimal monthly fee to keep your service in place.
Once you’ve been an Viasat Internet customer for at least one month, you’re eligible for the Hibernation Plan. Under this plan, you can suspend your service for two to six months at a time, for a total of up to six months in any 12-month period. Simply call Customer Care at 855-463-9333 and tell them you’d like to switch to the Hibernation Plan. Service will be suspended immediately after your call. When you’re ready to reactivate your full service, call Customer Care on the day you’d like it restored.
Fees: You will be charged a $9.99 monthly fee while you are on the Hibernation Plan. This fee replaces the monthly service fee on your regular Viasat Internet plan. You are still responsible for the monthly equipment lease fee (if applicable) and the fees for any other services you may have through Viasat, such as Voice. If you prepaid your equipment lease fee, the months during which you are on the Hibernation Plan will continue to be applied against your prepaid equipment lease fee.
Minimum Service Term: Your minimum service term continues to run while you are on the Hibernation Plan. For example, if you have 20 months left in your minimum service term when you switch to the Hibernation Plan and you are on the Hibernation Plan for 4 months, you’ll have 16 months left on your minimum service term when you switch back to your regular Viasat Internet plan.
Speeds: While you are on the Hibernation Plan, your access to the internet will be blocked. However, if you have Voice, you will continue to be able to make phone calls and you will continue to be charged at the usual monthly rate for your Voice service.
Eligibility: Customers on Exede5, Exede12 and WildBlue Recovery Act plans (customers with the black SurfBeam modem) and who have been under contract for at least 1 month are eligible to use the Hibernation Plan. Customers on Legacy WildBlue plans (customers with the blue SurfBeam modem) are not eligible for the plan.
Terms: You may suspend your service for two to six months at a time, for a maximum of six months in any 12-month period.
Read Frequently Asked Questions about the Hibernation Plan. | 2019-04-21T21:03:27 | https://www.exede.com/hibernation-plan/ |
Dr. Singh is an internationally recognized hepatobiliary and pancreatic surgeon. He is the Director of the Liver and Pancreas Center, Gastrointestinal Surgical Oncology at the John Wayne Cancer Institute (JWCI), St. John?s Health Center. Prior to moving to the JWCI, Dr. Singh was a faculty surgeon in the Department of Surgery at USC University Hospital. He has an extensive referral base that reflects peer recognition of his clinical acumen and surgical expertise and is listed as one of ?America?s Top Surgeons?. He is certified by the American Boards of Surgery and is a Fellow of the American College of Surgeons. | 2019-04-19T05:03:15 | https://www.dignityhealth.org/ourdoctors/1023048188-gagandeep-singh |
Painting in the style of the Divisionists, Louis Pigniollet enjoyed painting the landscapes of the Fousges, Jura and Franche-Comte areas of France. Using a colorful, yet somewhat muted palette his works capture the subtle light he saw before him. In this example, painted near the town of Voussey in Vosges area of France we see an open landscape with women washing clothes in the river.
Louis Pigniollet was born in the town of Roanne in the Loire Valley in 1869. A pupil at the Ecole des Beaux-Arts of Lyon he moved to Paris after graduating to establish himself as a professional painter. He admired the works of Corot although his style was very different. In 1909 he moved to the town of Saint-Maur which coincided with his change of style from a more traditional French ‘Paysage’ approach to the ideals of Seurat and Signac. Louis Pigniollet died in the town of Saint-Maur in 1946. A similar painting to this view in both proportion and style entitled ‘Le Chemin du Lac’ is illustrated in the Dictionaire des Petits Maitres by Gerard Schuur. | 2019-04-23T08:07:54 | http://www.kelleherfineart.com/inventory/gallery/552/details |
A deeper connection with your target audience.
By definition an eBook is simply an electronic version of a printed book. But eBooks have morphed into something different in the B2B Software space. The most effective eBooks are simple to read, showcase original thought leadership, and can be easily viewed on a mobile device. Less is more, but it’s not always easy to distill content down to the lowest common denominator.
Industry / Market Trends: Showcase challenges and opportunities and offer practical advice for how readers can overcome challenges and capitalize on opportunities. Generally this is in the form of a fact-filled asset that aggregates findings from reputable sources (analyst firms, new, consultants, etc.) and builds a strong story that change is necessary and urgent.
Branded Survey Findings Report: If your brand recently ran a customer survey we can use your data to help you showcase unique differences between your customers and the broader market. Many times there’s a litany of useful internal data that never sees the light of day. We can help you get the most out of available data.
Do I need data to publish an eBook?
Yes. While it is very common to see eBooks without facts or statistics they generally aren’t very valuable. But, we can do a lot of the heavy lifting around data collection if you are thinking about a point of view style eBook.
We can explore survey data you collected recently (within the last 12 months) from customers or a survey hosted by your brand.
We can host a survey and capture data for the report.
We can explore aggregated data on your customer usage trends.
Original data in an eBook generally has a shelf-life of 12-18 months which means the asset pays dividends for a longer period of time than a typical whitepaper. The data offers credibility and validation that the trends we are covering are worth the readers attention and time.
No. If you have ideas or a specific topic to write about that’s awesome. We are very skilled at identifying topics that will drive the most engagement with your target audience. We conduct pre-writing research to understand how the topic has been covered in the past and to make sure everything we produce is unique and valuable.
In most cases a realistic timeframe is 6-8 weeks from kickoff to production ready asset. It really depends on the quality of available data or market research. If we need to host and promote a survey this usually extends a project by 3-4 weeks.
We offer professional ghostwriting services; all frameworks, graphics, copy, and content are yours to use or re-use as you see fit.
We deliver a production ready PDF of your eBook with custom layouts and creative. We can mimic branded collateral or come up with an original layout using your brand compliant logos, color scheme, and image style.
We also provide the raw InDesign files and any creative assets we use. | 2019-04-21T02:57:23 | http://www.demandroi.com/what-we-do/professional-writing-services/ebooks/ |
After years of working with Víntegris, the company started 2017 with all new features: Rebranding to vintegrisTECH, new solutions such as NebulaSUITE, calls to be having a disrupting effect on the market and internationalization.
Independent consultant specialized in the design, development and evaluation of communication, marketing and PR strategies for companies and public organizations.
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Acepto que EYCOM almacene y gestione mis datos. | 2019-04-18T19:25:53 | http://eycom.net/en/em_portfolios/vintegristech-project/ |
So, yeah. That Garriott guy that made Tabula Rasa apparently didn’t get the ‘ur game failed’ memo, and is going off on some brand new tangent to try and drum up new subscribers. I think that's him on the right. One is the loneliest number, so I could see how being the only person playing an MMO you created could wear you down.
Apparently, if you subscribe to Tabula Rasa now you can have some DNA (?) shot off into space or something. While it might be neat if your DNA was found by aliens, cloned into some mutated superhuman army, and sent back to Earth to colonize the planet for… ok wait, this actually sounds pretty rad.
However! There are a few things horribly wrong with the implementation. Apparently you can’t bite off your finger and have them send that into space, it’ll just be some dumb ‘DNA Sequence’ file on a flash drive or some crap. While I hope our alien friends are advanced enough to have evolved to the USB 1.1 specification (lol 12Mbits/sec ), what happens if their laptop hard drives are some new, ohidunnoALIEN, file system? Maybe they’ll load our DNA sequences in their alien version of WinAmp, and the sound shooting forth might be some horrendous battle cry. Even worse, what if it’s a mating call, and they all come to Earth expecting surprise alien buttsecks?
There are so many things wrong with the idea it’s just silly. The website takes another turn for the worse when they start soliciting ideas for ‘Mankind’s Greatest Achievements’ and then it asks you what your favorite movie is.
I guess that’s better than ‘Which was your favorite episode of Friends’?
You go, Richard Garriot. Just… you go girl. | 2019-04-25T01:00:14 | http://www.ixobelle.com/2008/08/operation-immortality.html |
The Frank G. Zarb School of Business continues to celebrate the opening of its new home with a panel discussion Thursday, March 28, featuring three prominent business leaders, followed by tours of the school’s new, state-of-the-art building.
Meet the C-Suite: Leading the Workforce of Tomorrow will feature Stella Mendes, Senior Managing Director, Forensic and Litigation Consulting at FTI Consulting, and Michael Roberge, Chief Executive Officer at MFS Investment Management. The panel will be moderated by Frank G. Zarb, Senior Advisor to Promontory Financial Group, an IBM Company and Former Chairman and CEO of the NASDAQ Stock Exchange. All three are Hofstra alumni, and Roberge and Zarb are members of Hofstra’s Board of Trustees.
The panel discussion will begin at 6 p.m. in Monroe Lecture Center, South Campus. A reception and tours of the Business School Building will begin at 7 p.m.
The new building opened to students for the Spring 2019 semester. The 52,000-square-foot space is equipped with a new Behavioral Research in Business Lab, an enhanced Center for Entrepreneurship, makerspace/startup incubator, multiple areas for student independent and collaborative study, as well as administrative, faculty and student club offices.
For more information or to RSVP, go to hofstra.edu/meetthecsuite. To learn more about the new business school building, visit business.hofstra.edu/newbuilding. | 2019-04-22T08:51:45 | https://news.hofstra.edu/2019/03/21/meet-the-c-suite/ |
How has membership in the Stow-Munroe Falls Chamber of Commerce benefitted your business? “Community involvement is a very important part of who we are. Our marketing efforts through the Chamber (i.e. Title Sponsor of the Annual Golf Outing; Business After Hours host; Friday eblasts, etc.), help us to achieve that goal,” stated Bob Frangos, Owner.
Do you have suggestions for other members seeking to get the most out of their membership? “Yes, take a second look at the various services available to you through your membership. The results will be worth your effort!
The Club has been a Member for years, I have been with the Club and participating in the Chamber events since March 2011. My business is all about relationships, so being new to the community and having the opportunity to meet and network with the business owners and representatives at Chamber events has been invaluable to me. Many of our Club’s Members are small business owners and also Members of the Chamber. Attend events, introduce yourself to people and don’t be afraid to walk up to a group. Stow is fortunate to have a lot of people working and living in the community who have been here their whole lives, so they have deep roots. Many of the Chamber Members have known each other for years, dating back to their school days. My husband and I moved “home” to Ohio from Orlando, Florida are so happy that we chose Stow as our place to live. We were looking for vibrant, growing city with a small town atmosphere and we found it in Stow. We have been welcomed with open arms and thank you!
Have a testimonial? Email us now! | 2019-04-25T20:36:16 | http://smfcc.com/testimonials/ |
live.step displays multiple sequences which have multiple steps composed of pitch, velocity, and duration. Two additional steps (Extra 1 and Extra 2) are available for user-defined display.
When set to 1, this attribute lets you expand the scrolling dragging the cursor to the edge of the display or to drag a selected pitch beyond the range of the current visual display.
Sets the background color of the live.step object in RGBA format.
Sets the second background color of the live.step object in RGBA format.
Sets the ruler background color of the live.step object in RGBA format.
Sets the unit background color of the live.step object in RGBA format.
Sets the color for the upper (black) keys in RGBA format.
Sets the border color of the live.step object in RGBA format.
Sets the sequence to be displayed (index numbering starts at 1).
When the editlooponly attribute is set to 1, the edit messages ( up , down , left , right , random , scramble , sort ) are only applied to indices inside the loop selection.
Sets the maximum value for the user-definable extra1 layer.
Sets the thickness of the vertical bars displayed in the extra1 layer. Values should be in the range of 0. (invisible) to 1.0 (full width).
Sets the highlight background color of the live.step object in RGBA format.
Sets the loop border color of the live.step object in RGBA format.
Toggles the display of the loop ruler.
An integer or symbol can be used to set the information display mode of the live.step object.
Display note, velocity, duration, and user-definable extra1 and extra2 values at once.
Defines the number of sequences.
Sets the step color of the live.step object in RGBA format.
Sets the second step color of the live.step object in RGBA format.
Defines the sequence to be edited (index numbering starts at 1).
Sets the text color of the live.step object in RGBA format.
Toggles the display of the unit ruler.
Sets the color for the lower level (white) keys in RGBA format.
If the target_seq attribute is set to zero, a bang message will send the values associated with the current step of all sequences out the object's left outlet. If the target_seq attribute is set to a value greater than zero, a bang message will send the values associated with the current step of the currently specified sequence out the object's left outlet.
If the target_seq attribute is set to zero, an integer sets the current step of all sequences to the corresponding integer (index numbering starts at 1). If the target_seq attribute is set to a value greater than zero, an integer sets the current step of the currently specified sequence. The values associated with the current step are sent out the object's left outlet.
If the target_seq attribute is set to zero, the message active 0 deactivates all sequences. The word active , followed by any non-zero value, will activate all sequences.
If the target_seq attribute is set to a value greater than zero, the message active 0 deactivates the specified sequence. The word active , followed by any non-zero value, will activate the specified sequence.
The word copy will copy the entire sequence. One or two optional integer arguments may be used to specify starting and ending indices (index numbering starts at 1). For example, copy 2 will copy the sequence starting at index 2, while copy 2 5 will copy starting at index 2 and ending at index 5.
Replaces the current sequence or all sequences of live.step by the content of a named dictionary. If multiple sequences are present in the dictionary, every sequences is replaced.
0 : transpose the pitch upward.
1 : transpose the pitch downward.
2 : Rotate the steps to the left.
4 : Randomize steps depending on the mode attribute. For instance, if the mode is set to velocity, doedit 4 will only randomize the velocity.
For more advanced editing features, use the up , down , left , right , random , scramble , and sort messages.
Sends the values (pitch, velocity, duration, extra1, extra2) of all steps of the currently specified sequence out the live.step object's right outlet.
Sends out a dictionary of the current sequence or all sequences (if target_seq is set to 0), via the dump outlet.
The word duration , followed by an integer that specifies a starting index into a sequence (index numbering starts with 1) and a list of values (in ticks), will set the duration values for the current sequence specified by the target_seq attribute.
The word extra1 , followed by an integer that specifies a starting index into a sequence (index numbering starts with 1) and a list of values, will set the extra1 values for the current sequence specified by the target_seq attribute.
The word extra2 , followed by an integer that specifies a starting index into a sequence (index numbering starts with 1) and a list of values, will set the extra2 values for the current sequence specified by the target_seq attribute.
If the target_seq attribute is set to zero, the integer argument sets the direction of all sequences when live.step object's playback is controlled using the time message.
If the target_seq attribute is set to a value greater than zero, an integer sets the direction of the specified sequence when live.step object's playback is controlled using the time message.
The word down will decreases the values of the sequence based on the target_seq and mode attributes. For instance, if the mode attribute is set to velocity, the down message will only decrease the velocity of the currently specified sequence (or all the sequences if the target_seq attribute is set to zero).
The message getactive will send the active state of the currently specified sequence out the live.step object's fourth (dumpout) outlet in the form of a list preceded by the word active .
The message getcurrentstep will send the current step of the sequence out the live.step object's fourth (dumpout) outlet in the form of a number preceded by the word currentstep . When working with multiple sequences, the getcurrentstep message will report the current step of the targeted sequence (specified by the target_seq attribute).
The word fold , followed by a 0 or 1, toggles the folded display mode. When folding is enabled, the live.step object only displays those pitches which are present in the sequence specified by the target_seq attribute rather than all possible pitches. Fold mode displays only the pitches specific to each individual sequence .
Note: Sequence editing messages such as up , down , and random use the list of pitches displayed in fold state when performing operations (i.e., the random message will only choose randomly from among the pitches displayed on fold mode. These operations are also dependent on the target sequence, as well). for all sequences.
The message getduration will send a list of all the duration values in the sequence specified by the target_seq attribute out the live.step object's fourth (dumpout) outlet in the form of a list preceded by the word duration .
The message getextra1 will send a list of all the extra1 values in the sequence specified by the target_seq attribute out the live.step object's fourth (dumpout) outlet in the form of a list preceded by the word extra1 .
The message getextra2 will send a list of all the extra2 values in the sequence specified by the target_seq attribute out the live.step object's fourth (dumpout) outlet in the form of a list preceded by the word extra2 .
The message getdirection will send the direction state of the currently specified sequence out the live.step object's fourth (dumpout) outlet in the form of a list preceded by the word direction .
The message getinterval will send the interval of the currently specified sequence out the live.step object's fourth (dumpout) outlet in the form of a list preceded by the word interval .
The message getloop will send the loop points of the currently specified sequence out the live.step object's fourth (dumpout) outlet in the form of a list preceded by the word loop .
The message getnstep will send the number of steps in the currently specified sequence out the live.step object's fourth (dumpout) outlet in the form of a list preceded by the word nstep .
The message getmodelist will send the list of the display modes out the live.step object's fourth (dumpout) outlet in the form of a list preceded by the word modelist .
The message getpitch will send a list of all the pitch values in the sequence specified by the target_seq attribute out the live.step object's fourth (dumpout) outlet in the form of a list preceded by the word pitch .
The message getstep will send a list of the values (pitch, velocity, duration, extra1, extra2) of the specified index of the currently specified sequence out the live.step object's fourth (dumpout) outlet in the form of a list preceded by the word step .
The message getvelocity will send a list of all the velocity values in the sequence specified by the target_seq attribute out the live.step object's fourth (dumpout) outlet in the form of a list preceded by the word velocity .
The word fetch , followed by a symbol that specifies a step parameter (pitch, velocity, duration, extra1, or extra2) and an integer that specifies a step number, will send a list out of the live.step object's fourth (dumpout) outlet in the form <parameter-name> <step-number> <value> .
The message getzoom will send the zoom pitch values of the currently specified sequence out the live.step object's fourth (dumpout) outlet in the form of a list preceded by the word zoom .
The word fold_pitch , followed by an integer or list of integers that specify MIDI note numbers, sets the pitches to be displayed by the live.step object in fold mode. As with the fold message, the fold_pitch message sets pitches to be displayed in the sequence specified by the target_seq attribute.
Restores and outputs the initial values entered when Initial Enabled is checked in the live.step object's Inspector.
Sets the interval of the currently specified sequence.
The word left will rotate (left-shift) the values of the sequence based on the target_seq and mode attributes. For instance, if the mode attribute is set to velocity, the left message will only rotate the velocity of the currently specified sequence (or all the sequences if the target_seq attribute is set to zero).
The word loop , followed by two numbers that specify starting and ending indices, sets the loop points of the currently specified sequence.
The next message will send the values associated with the next step of all sequences out the object's left outlet. If the target_seq attribute is set to a value greater than zero, a next message will send the values associated with the next step of the currently specified sequence out the object's left outlet.
Sets the number of steps in the target sequence.
0: The pitch, velocity, duration, extra1, or extra2 settings have been modified.
1: The looping portion of the UI has been modified.
2: Edits have been made in the ruler area of the UI.
When the paste message is received without argument, all parameters are pasted at the same location as they were copied. An optional argument to specify parameter type (pitch, velocity, duration, extra1, extra2) can be used to paste only specific items. An additional option number argument specifies the starting index where the copied steps will be pasted (index numbering starts at 1).
The word pitch , followed by an integer that specifies a starting index into a sequence (index numbering starts with 1) and a list of values, will set the pitch values for the current sequence specified by the target_seq attribute.
If the target_seq attribute is set to zero, the word set , followed by an integer sets the current step of all the sequences to the corresponding integer (index numbering starts at 1).
If the target_seq attribute is set to a value greater than zero, the word set , followed by an integer sets the current step of the currently specified sequence.
The word random will randomize the values of the sequence based on the target_seq and mode attributes. For instance, if the mode attribute is set to velocity, the random message will only scramble the velocity of the currently specified sequence (or all the sequences if the target_seq attribute is set to zero).
The reset message allows you to deactivate the current step. It is equivalent to setting the current step to 0.
The word right will rotate (right-shift) the values of the sequence based on the target_seq and mode attributes. For instance, if the mode attribute is set to velocity, the left message will only rotate the velocity of the currently specified sequence (or all the sequences if the target_seq attribute is set to zero).
The word time , followed by a list of 6 numbers, defines the timing position in the sequence. The required arguments are bar , beat , unit , resolution-in-ppq , time-signature-numerator , and time-signature-denominator . The live.step object does not have an internal clock , so you need to send the time message often if you want to use it to drive the live.step object.
The word scramble will randomize the order of the values of the sequence based on the target_seq and mode attributes. For instance, if the mode attribute is set to velocity, the left message will only scramble the velocity of the currently specified sequence (or all the sequences if the target_seq attribute is set to zero).
If you are not using mode all, and that you pass 1 as argument, scramble will keep your steps synchronized. For instance, the scramble pitch 1 message will reorder the pitches, but the other parameters will follow.
The word setall , followed by a number, will assign that value to every layer in the currently targeted sequence when the the live.step object is in display mode. An optional first argument specifying a specific layer (i.e. setall velocity 85 ) can be used to set all values in a specify layer. When the editlooponly attribute is set to 1, the setall message will only be applied to indices inside the loop selection.
The word settimeshift , followed by a positive or negative number that specifies an offset, will move to the relative position from the current step in the sequence and first that step (e.g., sending the message settimeshift -1 when the current step number is 3 will cause the content of step 2 to fire.
The word sort will sort the step values of the sequence based on the target_seq and mode attributes. For instance, if the mode attribute is set to velocity, the sort message will only sort the velocity values of the currently specified sequence (or all the sequences if the target_seq attribute is set to zero).
1 : Ascending (the default) -1 : Descending.
The word velocity , followed by an integer that specifies a starting index into a sequence (index numbering starts with 1) and a list of values, will set the velocity values for the current sequence specified by the target_seq attribute.
The word up will increase the values of the sequence based on the target_seq and mode attributes. For instance, if the mode attribute is set to velocity, the up message will only increase the velocity of the currently specified sequence (or all the sequences if the target_seq attribute is set to zero).
Sets the the upper and lower displayed range of the currently specified sequence.
The word zoom_in will cause the currently displayed pitch range of the live.step object to adjust so that the highest and lowest note values become the upper and lower limits of the display.
The word zoom_in will cause the current pitch range of the live.step object display to decrease by a factor of a fifth (7 steps) at the top and bottom, resulting in a "zoom in" effect.
The word zoom_out will cause the current pitch range of the live.step object display to increase by a factor of a fifth (7 steps) at the top and bottom, resulting in a "zoom out" effect.
Out the fourth outlet: The output in response to dumpout messages used to query the live.step object.
Out the third outlet: Mouseover information.
Out the fifth outlet: Sequence index out.
Out the leftmost outlet: Step values.
Out the second outlet: Current loop points for each sequence. | 2019-04-21T22:19:54 | https://docs.cycling74.com/max7/maxobject/live.step |
Using agile methods is a great way for businesses to adapt in an ever changing market. It gets harder to implement, however, the more your business grows.
So, how can you encourage agile adoption across your teams and people?
We held a meetup to analyse this question and scaling agile as a whole. Our panel of speakers Sam Zawadi, Amanda Colpoys and Mark Jeckells proved to be a great hit with the audience.
Topics included "Agile at scale" with two case studies on Moonpig's agile transformation journey. You can find all the slides for these below.
A big thank you to all those who attended, and to our host on the night Sarosé Burnley! | 2019-04-23T16:05:46 | https://www.argyllscott.co.uk/blog/2018/05/scaling-agile-meetup |
Heavy rainfall and subsequent flooding has led to fatalities, massive displacement, and damage to infrastructure and cropland.
Needs are expected to increase in displacement sites and riverine areas in the near term.
Based on results of assessments conducted across Somalia in June and July 2017 by FSNAU and FEWS NET, in collaboration with government and other partners, levels of acute food insecurity and malnutrition will remain high in Somalia through the end of the year. In the worst-case scenario where humanitarian assistance is scaled down substantially, food prices increase sharply, and the Deyr rains perform poorly, Famine (IPC Phase 5) is possible. | 2019-04-19T08:56:56 | http://www.fsnau.org/fsnau-in-focus |
"He's the best, and I'm happy to call him my friend!"
"Amin, he is such a great musician ! Danke Amin für einen schönen Abend!!!"
"He is one of the best performers I have ever seen!!!"
"Amin you always put a smile on my face when I listen to your music"
"Wow Amin Safari, once again you did it! your work is so unique and you are one of best musicians and so talented!"
"I love listening to and watching them perform. If you ever have a chance to see Amin Safari perform around Houston, take it!"
"Amin Safari, you are an amazing talent. As an amateur musician I know how difficult it is to sound that accomplished. What you can with a guitar not only pleases the soul, but blows the mind." | 2019-04-19T23:22:14 | http://amin-safari.com/ |
Stoneleigh-Burnham School (SBS) and the Greenfield Public Schools have begun a partnership in equestrian studies that gives Greenfield middle school students an incredible opportunity to learn about horses and riding from seasoned SBS equestrian faculty and staff and talented student riders.
The partnership was developed by SBS Equestrian Director George Halkett and Greenfield Middle School (GMS) Associate Principal Angela Ruggeri with the encouragement of Greenfield School Superintendent Jordana Harper.
Under the partnership, 21 sixth-grade girls and boys from Greenfield Middle School visit the SBS equestrian center on Stoneleigh-Burnham’s campus each school day for an hour and a half and work with at least one SBS student rider, along with Halkett and other equestrian staff.
Ruggeri and Halkett explained that SBS has offered this opportunity to GMS at a greatly reduced rate. The program is funded in large part by an Expanded Learning Time grant for student enrichment awarded to GMS.
Halkett said GMS students will earn certificates in Horse Knowledge and Riding at the end of the school year. SBS student and rider Linda Limeri ’16 works with the middle school students each day.
Limeri is earning practical training hours toward her British Horse Society (BHS) Certification. SBS is the first and only U.S. secondary school to teach the BHS and with an equestrian center that has been certified as a BHS-approved facility. Long recognized internationally for setting the highest standards for riding instruction, stable management, and horse training, the system set forth by the BHS complements Stoneleigh-Burnham’s dedication to providing students who aspire to careers in horsemanship with a firm academic footing at the high school level.
For more information on equestrian offerings at SBS, click here. | 2019-04-20T23:18:14 | https://sbschool.org/equestrian-center-welcomes-greenfield-middle-school-learners/ |
In the early days of CMMI® – SVC, around 4 years ago, I purchased this book on the recommendation of my colleague Chinmay Pradhan . The money and time spent with this book have been rewarding. I now strongly recommend it to anyone who asks me for a book to understand the services context for implementation of CMMI® for Services.
The book is designed as a comprehensive standard text for management students in service oriented industries.
It has been used as reference book for many years – the first edition is dated 1994. The book has been updated frequently and has survived almost 2 decades.
The book (5th Edition) has 3 parts and 17 Chapters.
The Chapters on “The Nature of Services” and “Service Strategy” (in Part 1) are especially useful to structure your approach to a service oriented organization.
There are interesting Chapters (in Part 2) dedicated to development of new services, service quality, and continuous improvement.
Part 3 titled Managing Service Operations has a lot of material devoted to demand forecasting, capacity management, managing queues, and service supply relationship – this section is useful for approaching the high maturity practices of the CMMI®.
Concepts are supported with diagrams, tables, examples and case studies from a wide range of service industries. The range is so vast that based on reading the book, it is easy to extend the concepts to a completely new service industry/ organization.
Each chapter ends with questions for the readers to work on (and consolidate their understanding of the concepts).
The book may not be suitable in a Kindle version (I think the big illustrations and tables in the book are not suitable currently for the Kindle format).
The print version (5th Edition) that I have is close to 600 pages – just slightly smaller than the A4 size – so it is pretty big to carry around.
If you belong to one the above category of folks, in addition to reading the book, you will find it useful to have a copy for reference on a more constant basis.
The book has multiple editions (the 8th edition seems to be the latest) and multiple versions/ configurations (hardcover/paperback, with student CD/ without student CD) – the price varies significantly based on the edition, versions and configurations. My review is based on a paperback copy of the 5th edition, without the student CD. If you are planning to purchase a copy, keep in mind that the price is dependent on some of the factors just discussed.
James A Fitzsimmons is a BSE in industrial engineering (Univ of Michigan), an MBA (Western Michigan Univ) and a PhD (UCLA). He has consulted several organizations, including large government bodies. He has edited and co-authored many books and journals.
Mona J Fitzsimmons is a graduate from the University of Michigan, did her graduate work in geology. She has been a teacher and an author. Her activities/ interests include wildlife rehabilitation, environmental issues and health care.
I had earlier read two engrossing books by Atul Gawande – Complications and Better. So when I saw The Checklist Manifesto while browsing in the neighborhood library, I decided to pick it up looking forward to an interesting read (some reviewers had strongly recommended it). The title also indicated that it may a good book to review for this weblog.
Over the years, many activities have become extremely complex.
Even experts struggle to master and remember all the tasks they have to perform.
Use of checklists can minimize human errors of oversight. In many cases this it can improve the performance significantly.
Use of checklists can also help the experts focus on the difficult, tricky parts of a situation, rather than worry about the mundane activities.
There is need to create better checklists, organize them for easy use and ensure that they are used.
The author uses examples from multiple industries and situations. The best ones are from hospitals and medical emergencies (Dr Gawande is a surgeon :-)). There are other examples from the airline industry (where pilots use checklists for normal as well as abnormal situations), construction industry, retail, and restaurants.
There is a whole chapter dedicated to research where the impact of the use of checklists in hospitals was studied. The research showed that there was a significant reduction in deaths (47% reduction) and major complications (36% reduction) for surgical patients. One interesting finding was that though only 80% of the hospital staff found the checklists useful, 93% of them said they would want a checklist to be used if they were themselves getting operated!
In trying to bring everything under the umbrella of “checklists”, the author dilutes the concept and utility of checklists as well as other equally important concepts of detailed planning, collaboration, empowerment, dedication, competence and focus. Maybe the title “The Process Manifesto” would have been more apt.
For people who are already convinced about the use of checklists, procedures, plans, collaboration meetings, etc., this book can provide you with interesting examples to relate to process skeptics in your organization. It can also provide process trainers with interesting case studies to relate to the class. You may also consider gifting this book to colleagues who resist the use of formal processes – the book is an easy read and is able to hold the reader’s attention reasonably well.
If you are looking for readymade checklists that will help you reach some level in CMMI®/ People CMM®, then this book is not for you :-).
Those who have read Gawande’s earlier books – Complications and Better may find The Checklist Manifesto a bit disappointing – it is not as engrossing as the earlier two. This is possibly because the earlier books focused primarily on hospitals, medicine and healthcare based scenarios, where Gawande has accumulated loads of experience. And in Checklist, he provides examples from other industries (aircraft manufacture, real estate, retail stores, restaurants, and so on) where he may not have had the same level of familiarity and insight.
I was scanning the shelves of a book lending library, when I came across this book – the title intrigued me, so I picked it up and browsed through it. Based on the title, I had imagined an extraordinary organization of one person (me!) – it turned out to be something else, but interesting enough :-). Anyway, I borrowed the book, read it, and here is the review.
In the last few years, retail customer experience has been highly customized by internet based enterprises (e.g., Amazon, Netflix, Dell) with a great degree of success.
Employee experience too can be customized, to provide an environment to motivate each employee to deliver his/ her best for the organization.
This is required because people’s expectations have changed due to their experience as customers, because other organizations are already doing it, because it enables higher employee retention, engagement and productivity, and because it increases the ability to attract high potential employees. “One size fits all” is no longer a desirable approach.
Customization has become feasible because of the variety of tools and technology that are increasingly available.
According to the book, workforce practices have evolved from chaotic, ad-hoc, person-specific, unstructured, unfair systems to something that is monolithic, over-controlled, one-size-fits-all, and over-standardized. And now it is time to make the systems more flexible, tailored and customized.
Segment the workforce on dimensions like geography, tenure, career level, role, age, etc. to understand the requirements and needs of different segments.
Offer modular choices, in areas like compensation, working hours, learning methods, working place, etc. The modularity ensures structure and equity while providing flexibility.
Define broad and simple rules, instead of defining very elaborate policies and procedures. This will permit flexibility while ensuring that the values of organization are adhered to.
Foster employee-defined personalization by making people aware and enabling managers to guide employees to make appropriate choices.
The book covers multiple areas of people practices that can be customized. Some of them are rewards and recognition, learning, work place, work time, career growth pace and choices, assignment mix, performance goal setting and feedback mechanisms, compensation mix, benefits, and work place tools/ technology.
The authors use examples from organizations like Best Buy, Microsoft, Accenture, Procter and Gamble, Deloitte, The Container Store, Royal Bank of Scotland and others.
As a reader, I found some of the examples (illustrating the concept of customization) as being trivial. For example, the authors use the fact that a multi-national organization provides company transport to employees in Hyderabad (while it does not do so elsewhere in the world) as an example of customization (geographical segmentation). To me, this is like saying that the company follows Indian labor laws in India :-). Since the organization has set up their office far away from the city’s residential areas and the city does not have adequate public transport, there is no choice for the company but to arrange transport for the employees.
The problem with trivial examples is that on reading the examples, many people will go, “yeah, we do that, actually we started that 10 years ago”. And miss the whole concept of the customization approach.
The book is easy to read and grasp and proposes a powerful concept worth investigating. Definitely worth reading for senior HR folks and CXOs (just ignore the trivial examples :-)).
How do the concepts covered in the book align with the People CMM®? Well, that is the subject of another post, some other day! :-). | 2019-04-21T06:06:42 | https://alignmentor.com/tag/book-summary/ |
2. They actually purposely hung up on someone and pretended it was an accident.
3. They put a client on hold for incredibly long time hoping they would hang up.
4. They’ll do anything just to get the client off the phone.
5. They often exchange choicest “pleasantries”.
6. The rules and regulations in a call center can sometime make the environment feel like high school.
7. Despite of what people think, Employee’s of a call center has a 4 year undergraduate degree.
8. Authorization, to ask/ revel information can get “pretty confusing” on the phone.
9. They mute a client to look for more information but in actual they’re just taking a bit of their snack.
10. They keep a ton of snacks at their desk. | 2019-04-19T18:57:46 | https://dsim.in/blog/2015/11/24/11-call-centers-secrets-that-you-might-not-be-knowing/ |
In 2015, you helped elect a Liberal government which formed the first gender-balanced federal cabinet in Canadian history. Despite this victory for gender equality, and many others this year, we have more work to do to promote gender equality and inclusion for all women in Canada.
That is why I was very pleased to attend the Congress of Black Women (COBW) of Manitoba’s Annual Volunteer Awards & Fundraising Gala this fall. We honoured and celebrated ten “Unsung SHEroes:” Incredible female leaders whose contributions have inspired girls and women across communities in Manitoba to be leaders in their own right.
Our society can only achieve its full potential when women and vulnerable minorities enjoy the same opportunities as everyone else. I thank the COBW for all its work in promoting gender equality in our province. | 2019-04-21T00:07:32 | https://tduguid.liberal.ca/news-nouvelles/honouring-our-unsung-sheroes/ |
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coral pendant light replica is accessible with a lot of designs that you can choose dependant on your liking. Making your own personal design can be quite a choice likewise in particular when you're an architect. But making anybody can be too a great deal of hassle, don't you find it? This is exactly why we provided you lots of coral pendant light replica pictures so, it is possible to make a decision about the level of design you desire to install. You'll find modern looking design, stylish, glamour, luxurious, neon lights, and even more coral pendant light replica so, choose wisely. | 2019-04-19T20:41:30 | https://divineducation.com/home-lighting/coral-pendant-light-replica/attachment/coral-pendant-light-replica-best-edison-small-5-light-pendant-within-coral-pendant-light-replica/ |
In 2014, Montgomery Women’s Facility implemented a Web based Visitation System provided by Homewav. We are unsure as to how much Alabama Department Of Corrections takes in kickbacks, but CenturyLINK takes a cut of 40% of the extortionate $36 fee that is charged for a 60 minute “visit”. Homewav also charges a $1 handling fee every time money is added to the account so its effectively $37 for a 60 minute video call.
Whilst the idea of web based visitation is a good one if done ethically, Homewav certainly do not consider the inmates or their families in their business plan, all they care about is profit. For example, they claim that internet based visitation reduces the number of in-person visitation, by 75% and the families of those incarcerated don’t understand how cutting in-person visits from family and friends is in anyway beneficial to them.
The benefits of visiting with family and other supportive individuals are well documented throughout literature, research, and from the voices of the incarcerated men and women and their families. In person visiting can build and strengthen family connections and provide hope and encouragement for those incarcerated, lets not even entertain the thought of removing it in order to provide these predatory companies with even more of your hard earned cash.
Replacing in-person visitation with an internet based visitation system such as Homewav would be disastrous, they have no interest in corrections or rehabilitation, or an inmates ability to communicate with their families or an inmates welfare, all they care about is putting money into their pockets. It’s blatant Prison profiteering of the lowest order, insidious and predatory.
The hardware that they installed in the facility is apparently not fit for purpose. The computers regularly crash, they lose connectivity or completely freeze up but the families we spoke to said that even though their loved ones can’t hear or speak or even disconnect the call, Homewav still runs down their visitation minutes. It would appear that Homewav chose the lowest dollar value hardware that they could find, and it was installed by poorly trained individuals that lacked the professionalism to ensure that the system was functioning as it was apparently designed to do.
As a result its the female inmates that suffer, one example is that they did not align the web cameras properly, as a result, the women have to sit on books, or sit at an awkward angle to get into the view of the camera, they can’t adjust them themselves as they are fixed in the tamper-proof box, one camera has a piece of tape that has been placed over the lens since 2014 so you can only see half of the screen as this image clearly shows.
Other complaints include the deduction of all funds and being left with a negative balance. We were told that the new owners/management have told the staff that they are not give give refunds under any circumstance, nor are they to refund minutes that mysteriously disappear from their apparently flawed system.
Homewav operates with a handful of staff, and they hardly ever pick up the phone, one lady told us and when they do, they say they don’t give refunds. Perhaps a more serious question is that of vetting. For example, What is Homewav’s process of vetting staff? What are they watching inmates conversations for and who do they report this too, if at all? Whats the standards and processes that they follow? What privacy laws are being flouted? What is the retention policy of stored messages? Where are they stored and who has access to them? Is it secure?
Homewav are partnered with CenturyLink, so you would expect some semblance of quality of service right?
Well you’d be wrong there, other issues with the system include the handsets that the inmates speak through, they have had the volume level in the computer terminal set to low, so on at least one of the three terminals, the inmates almost have to shout in order for themselves to be heard by the other person, thats a difficult situation to be placed in, with a room full of people sat behind you in the TV room, frequently too, other inmates remove the chairs so those wishing to call a family member have to squat or stand and lean over in order to be seen on screen, the whole thing is just totally amateurish, don’t be fooled into thinking either that hundreds of thousands of dollars have been spent developing this software, we were shown on a popular “rent a coder” website, Homewav apparently having invited bids for fixing various issues within the system, from a gentleman based in Bangladesh.
Homewav’s system deletes your in credit balance and replaces it with a negative balance, how can they ignore this major flaw on a pre-pay system and claim that their accounting is accurate?
Taking a look at the site and its poor design, it does make you wonder that if they can’t even get the basics right, can you really rely on them backing the back-end accounting and billing system working right? Unfortunately not is the answer, Well the part that takes your money always works for them as its hosted by paypal, but with a top dollar price tag that the families and friends of those incarcerated have been forced to pay, for a service which is far superior and free, in the free world.
You can leave your loved one a message and vice versa, the rate per one minute message is $1.20, however the system is incorrectly deducting $2.00 per one minute message and despite Homewav being informed that their system is over-charging they have not adjusted the price or issued a refund.
Homewav’s system has the option of leaving your loved one a one minute message for $1.20, but it actually charges you $2.00 for the one minute message and they refuse to issue refunds. | 2019-04-23T20:08:31 | https://montgomerywomensfacility.com/2016/04/07/homewav-web-access-visitation-at-montgomery-womens-facility/ |
I don’t know about you but I don’t like being disturbed. Especially when it has taken me a while to get everything just the way it should be, and I can finally settle down into the comfort of the conditions I have created. Whether it be the way my office administration operates, or something smaller like settling down to have a cozy evening read; I dislike disturbance.
On this feast of the Epiphany Matthew tells us that Herod and the whole of Jerusalem were disturbed. It was all because some exotic Eastern mystics, called Magi, who drifted into Jerusalem, wanted to know where the child was who had been born as the king of the Jews.
I am puzzled as to why this should have made troubled Herod, and why Herod’s perturbation should have been so infectious as to disturb all of Jerusalem with him?
But when I remember how I dislike being disturbed I begin to understand Herod’s agitation. He had built himself a comfortable kingdom that worked for him. Obsequious enough to Rome, he was rewarded with “homeland” rule, much like the puppet leaders of the old South African regime were rewarded for their loyalty to the Pretoria Nationalists.
The mere thought that there was another “king” out there who could threaten Herod’s comfort was cause enough to disturb him. The fact that the whole of Jerusalem was agitated too, is testimony to the fact that there are very few societies that embrace change. Despite the graces of a Gandhi, Mandela or Obama, we still find change from our familiar power bases disturbing.
As we read on into this chapter however, we are given deeper clues as to the reason for the agitation. Herod like so many power players was agitated because at a deep level he knew that there were ethical issues at stake.
Shepherding is not associated with political power is it?
Rulers rule. Presidents preside. Leaders lead. Executives execute.
Shepherding implies compassion, care and a courageous life-sacrificing quality that few powerful people would understand or want to practice.
Yet this had always been the basis of Godly rule from the inception of the monarchy in Israel. The very first king David was called from the flocks to be the shepherd king, an archetype which was espoused and fulfilled in Jesus the good shepherd.
Herod, power player and man of maneuvering, could not begin to think of his leadership in those terms, and even though his scripture scholars may have pointed out that this was the scriptural paradigm, Herod knew that this was not how he came to power, and this was certainly not how he was going to stay in power.
So he turned his focus to bloodshed and destruction and is forever remembered as the butcher of the Bethlehem innocents.
I wonder how we are reacting to the reality that there is one amongst us who challenges our illegitimate power bases? This holy child whose birth we have totally over-celebrated, once again, last week.
Do we also want to “put him away” this Epiphany? Of course not in butchering bloodshed! We are too subtle for that. No we can simply pack this shepherd king away with the Christmas tree and lights, as we dismantle them on the twelfth day of Christmas and assign them to the musty cupboard till next Advent?
Are we also agitated and troubled by the thought that allowing this child to continue to grow in our “homelands” may cost us too much, and disturb our comfortable kingdoms more than we care for?
Herod hid from grace and terrible destruction was the fate and fruit of his life from then on.
Could we do it differently?
The mystical magi are knocking on the door. They speak of stars and destiny, and shepherd kings who can lead us to God.
Will we allow them to disturb us enough that we might join their caravan of change? | 2019-04-23T02:17:36 | https://thelisteninghermit.com/tag/matthew-21-12/ |
The US NTA/CWW team plays a large role coordinating research across countries, but has also produced work on gendered economic patterns in the United States. Despite the enormous convergence in market labor force participation for women and men since the early 20th century, the legacy of gendered economic roles endures.
CWW research highlights current differences in average labor income and time spent on market work versus unpaid care work by age. | 2019-04-25T23:41:47 | https://www.countingwomenswork.org/country-teams/united-states |
Tell us about your project. We are here to make your dreams a reality!
Exclusive – Fantasy White Marble Sandblasted Paver. | 2019-04-19T10:15:52 | https://www.pyramidsusa.com/contact-us/ |
SUNNY SAN DIEGO | To Arizona......and beyond!
We had a lovely trip to San Diego for Thanksgiving weekend. It was nice and sunny during the day and just a little bit chilly at night. We stayed right on the downtown waterfront in a lovely hotel with a view of the USS Midway from our window.
We had a trip to Torrey Pines State Natural Reserve which had views along the coast and rugged rock formations. We walked around Balboa Park and admired the grand buildings. We found the Gas Lamp district (we missed it on our last visit to San Diego) and looked at some of the little shops and cafes.
Our favourite beach was Mission Beach and we walked the 6 miles along the boardwalk twice during our trip, picking out the houses we’d like to own when we win the lottery!
As always food played a big part in our trip. We had 3 amazing breakfast trips which I’ll do a separate post about. We had Thanksgiving at Seasons 52 as it was directly opposite our hotel and they had a special menu so we could try turkey with all the trimmings – cronbread stuffing, maple roasted sweet potatoes, mash, green beans and cranberry relish. The gravy was white and thick which was unusual but very tasty. They also served rosemary bread with pumpkin butter and for pudding they had a mini pumpkin pie served in a shot glass. It was made up of the filling and the crust in layers with a ginger biscuit on top. A nice way to be able to try a traditional desert but I still don’t think we’re a massive fan of the pumpkin flavour, maybe it’s something that grows on you with time!
Another of our favourite things to do is to picnic. This time we had White Chocolate and Cranberry bread from Whole Foods which sounded so unusual we had to try it. It was actually really nice so we’re tempted to see if our local Whole Foods has the Ginger and Cranberry flavour that was the other option we saw. We also ate two homemade cookies from the Cravery which was a beautiful, tiny cookie shop which does a cookie subscription service so even if you don’t live close you can get their cookies delivered to your door….now there’s a good idea! We sat beside “Model Boat Lake” and watched a race of mini radio controlled sailboats while we ate, it was very entertaining!
It is a great idea isn’t it?!
Oh p.s. there’s this app called Deliveroo, I ordered cookies from a shop in London ha ha!
We loved Mission Beach, must have been a lovely place to live and good weather definitely helps your mood. Gravy is funny, how the same idea can be so different in two different countries! I can’t believe more people don’t deliver baked goods, I would definitely subscribe! Thanks for hosting. | 2019-04-19T16:25:10 | https://toarizonaandbeyond.wordpress.com/2015/12/04/sunny-san-diego/ |
Kick-start an exciting career in the IT industry by beginning your education in computer applications. Those who specialize in computer applications will learn how to develop and modify software, customize software for client use, design databases individually or as part of a team, and much more. What are you waiting for? Launch an exciting career into computer operations while focusing on word processing, spreadsheets, and databases. | 2019-04-24T17:59:13 | http://www.collegebound.net/schools/bachelors/computer-applications/browse-by-location/ |
Sorry - not sound ..
Sorry, at the moment Gernot is not making any sound.
Please come back later, or check out the announements on Gernot's Facebook page. | 2019-04-26T02:14:35 | http://gernotuntergruber.com/listen/see |
Price includes UK mainland delivery and LIFETIME UK based technical support, manned 12 hours a day during normal weekdays.
Where an operating system is supplied, we supply the complete genuine Microsoft Windows DVD/CD and COA license.
Reasons why you should buy this PC system?
The PC system is our own PowerMaster brand name and offers the user the very latest in INTEL CORE-2-QUAD CORE processor technology. Meaning the PC system can handle TRUE multitasking without no hesitation with 4, QUAD processing cores. This PC system uses only the highest quality branded internal components, a super silent 500W high power, power supplt meaning you get the very best in reliability, high performance and product longevity. The PC system will last for many years and is an amazing high performance gaming system. This comes thanks to its internal high quality GIGABYTE mainboard, that uses components that are modular solid-state designed to increase product life. This sort of high grade internal technology is'nt found in cheaper competitor's PC systems or our main line competitor's in the UK. We believe that using the right internal components adds not just value but optimum reliability to the end PC product. Our PC systems have been designed to offer the best internal cooling that equates to end user reliability. We don't just comprimise on components and design to obtain the cheapest possible price to beat competitors, we ONLY use high quality PC components to construct our state-of-the-art PC systems, meaning that the end PC system product is the VERY BEST.
This PC system can be of course be fully customised to suit your needs. We can still provide this PC system with Windows XP and have not gone down the same line as many competitors in offering Windows VISTA only if you require the optional installation of an operating system. Please note this PC system comes with NO operating system as standard. Please call us prior to ordering if you require Windows XP or VISTA.
OK here's the techy stuff. We have tried to simplify the PC's specification but if you need more detailed technical specification contact us before ordering. At the heart of this beast of a PC system is the latest high performance INTEL CORE-2-DUO QUAD CORE processor. It will handle many common home/office tasks with ease and you'll notice an incredable speed difference when your performing multitasking applications, e.g. running a virus check at the same time as exploring the internet. Because this high performance PC system uses the latest QUAD CORE processor technology the system won't be slowed down by things like automated virus scans in the background. It will glide along and you won't even notice any reduction in overall system performance like normal pc systems without QUAD or DUAL CORE. Thanks to its massive 4GB of DDR 2 800MHz high speed memory your applications will have plenty of run-time memory and as this PC system has dedicated PC-Express, NVidea Geforce 9600 1GB graphics card supporting the latest Direct X 10 graphics standard and HD/ TWIN VIEW output using the latest high performance DVI(Digital Video), interface, high performance games will run with ease. For storage this PC system has a massive 500GB high speed SATA 2 hard-drive and for all your DVD/CD playback a super internal Samsung DVD-RW multidrive. This DVD-RW drive supports all the DVD standards including RW/R/RAM as well as LightScibe Labling Function. This allows you to create your own CD/DVD lables and burn the design directly onto the top surface of the CD/DVD disk, with special CD/DVD media of course. So no more messy CD-writing pens anymore!
To make practical use of todays ever popularity of digital memory cards, this PC system has a built in digital memory card reader that will read and WRITE all popular digital memory card formats and plus you can just download your latest photos from your camera's digital memory card without even connecting your whole camera to the PC! Just slide your camera's memory card into the slot on the front of the PC and there you go, your photos are instantly downloaded to your PC!. As this PC system is designed as a complete base unit upgrade it does not come with any display, keyboard or mouse, etc. If you need any of these peripherals please call us for upgrade costs before ordering. So if your looking for a new upgraded PC system that will be the only system you'll ever need, then our Synergy QUAD CORE PC system represents the ideal and only choice and remember we offer complete UK based technical support(unlike our main competitor). Our UK based technical support is manned 12 hours a day during normal weekdays. This PC system comes with 2 years complete parts and labour warranty as standard. If you require any other upgrades, including a 2nd DVD-RW/DVD-BlueRay player/writer drive or even more memory, upgraded to a maximum of 8GB on the state-of-the-art PC system, please call us before ordering. | 2019-04-22T02:40:03 | http://www.premiergent.co.uk/pages/computers/ListingDetails.asp?ProductIDCode=QUADPCQ9300 |
Here's a list of water related terms that might help you understand your well water better. There is also a detailed water glossary kept by the Water Quality Association, and an extremely detailed water dictionary is offered by the Nevada Division of Water Resources.
A acequia--acequias are gravity-driven waterways, similar in concept to a flume. Most are simple ditches with dirt banks, but they can be lined with concrete. They were important forms of irrigation in the development of agriculture in the American Southwest. The proliferation of cotton, pecans and green chile as major agricultual staples owe their progress to the acequia system.
artificial recharge--an process where water is put back into ground-water storage from surface-water supplies such as irrigation, or induced infiltration from streams or wells.
B base flow--sustained flow of a stream in the absence of direct runoff. It includes natural and human-induced streamflows. Natural base flow is sustained largely by ground-water discharges.
C capillary action--the means by which liquid moves through the porous spaces in a solid, such as soil, plant roots, and the capillary blood vessels in our bodies due to the forces of adhesion, cohesion, and surface tension. Capillary action is essential in carrying substances and nutrients from one place to another in plants and animals.
D desalination--the removal of salts from saline water to provide freshwater. This method is becoming a more popular way of providing freshwater to populations.
E effluent--water that flows from a sewage treatment plant after it has been treated.
filters / filtering--a filter is a device used to catch and retain impurities such as suspended solids found in water. Whole House, sand, screen, spindown and reverse osmosis filters are very common on well water systems.
G gage height--the height of the water surface above the gage datum (zero point). Gage height is often used interchangeably with the more general term, stage, although gage height is more appropriate when used with a gage reading.
H hardness--a water-quality indication of the concentration of alkaline salts in water, mainly calcium and magnesium. If the water you use is "hard" then more soap, detergent or shampoo is necessary to raise a lather.
I impermeable layer--a layer of solid material, such as rock or clay, which does not allow water to pass through.
L leaching--the process by which soluble materials in the soil, such as salts, nutrients, pesticide chemicals or contaminants, are washed into a lower layer of soil or are dissolved and carried away by water.
M maximum contaminant level (MCL)--the designation given by the U.S. Environmental Protection Agency (EPA) to water-quality standards promulgated under the Safe Drinking Water Act. The MCL is the greatest amount of a contaminant that can be present in drinking water without causing a risk to human health.
N nephelometric turbidity unit (NTU)--unit of measure for the turbidity of water. Essentially, a measure of the cloudiness of water as measured by a nephelometer. Turbidity is based on the amount of light that is reflected off particles in the water.
NGVD--National Geodetic Vertical Datum. (1) As corrrected in 1929, a vertical control measure used as a reference for establishing varying elevations. (2) Elevation datum plane previously used by the Federal Emergency Management Agency (FEMA) for the determination of flood elevations. FEMA current uses the North American Vertical Datum Plane.
O organic matter--plant and animal residues, or substances made by living organisms. All are based upon carbon compounds.
osmosis - Reverse Osmosis--the movement of water molecules through a thin membrane. The osmosis process occurs in our bodies and is also one method of desalinating saline water.
P pH--a measure of the relative acidity or alkalinity of water. Water with a pH of 7 is neutral; lower pH levels indicate increasing acidity, while pH levels higher than 7 indicate increasingly basic solutions.
polychlorinated biphenyls (PCBs)--a group of synthetic, toxic industrial chemical compounds once used in making paint and electrical transformers, which are chemically inert and not biodegradable. PCBs were frequently found in industrial wastes, and subsequently found their way into surface and ground waters. As a result of their persistence, they tend to accumulate in the environment. In terms of streams and rivers, PCBs are drawn to sediment, to which they attach and can remain virtually indefinitely. Although virtually banned in 1979 with the passage of the Toxic Substances Control Act, they continue to appear in the flesh of fish and other animals.
R rating curve--A drawn curve showing the relation between gage height and discharge of a stream at a given gaging station.
runoff--(1) That part of the precipitation, snow melt, or irrigation water that appears in uncontrolled surface streams, rivers, drains or sewers. Runoff may be classified according to speed of appearance after rainfall or melting snow as direct runoff or base runoff, and according to source as surface runoff, storm interflow, or ground-water runoff. (2) The total discharge described in (1), above, during a specified period of time. (3) Also defined as the depth to which a drainage area would be covered if all of the runoff for a given period of time were uniformly distributed over it.
S saline water--water that contains significant amounts of dissolved solids.
septic tanks--a tank used to detain domestic wastes to allow the settling of solids prior to distribution to a leach field for soil absorption. Septic tanks are used when a sewer line is not available to carry them to a treatment plant. A settling tank in which settled sludge is in immediate contact with sewage flowing through the tank, and wherein solids are decomposed by anaerobic bacterial action.
T tertiary wastewater treatment--selected biological, physical, and chemical separation processes to remove organic and inorganic substances that resist conventional treatment practices; the additional treatment of effluent beyond that of primary and secondary treatment methods to obtain a very high quality of effluent. The complete wastewater treatment process typically involves a three-phase process: (1) First, in the primary wastewater treatment process, which incorporates physical aspects, untreated water is passed through a series of screens to remove solid wastes; (2) Second, in the secondary wastewater treatment process, typically involving biological and chemical processes, screened wastewater is then passed a series of holding and aeration tanks and ponds; and (3) Third, the tertiary wastewater treatment process consists of flocculation basins, clarifiers, filters, and chlorine basins or ozone or ultraviolet radiation processes.
U unsaturated zone--the zone immediately below the land surface where the pores contain both water and air, but are not totally saturated with water. These zones differ from an aquifer, where the pores are saturated with water.
W wastewater--water that has been used in homes, industries, and businesses that is not for reuse unless it is treated.
X xeriscaping--a method of landscaping that uses plants that are well adapted to the local area and are drought-resistant. Xeriscaping is becoming more popular as a way of saving water at home. | 2019-04-23T12:28:19 | http://www.wellwaterguide.net/well-water-glossary.aspx |
Looking for Bath Enclosures in Kramer Junction? We have exemplary workmanship and the finest of products.
There are hundreds of choices when it comes to the design of your perfect shower or bath enclosure for your home in Kramer Junction. You can combine the components in a variety of ways to satisfy every family member. Our expert designers work with you to achieve the ideal combination of style and function that complements the aesthetic of your home and your budget.
Multi-function showerheads deliver a variety of functions, specific massage options and a range of intensities, from pulsing blasts to gentle mists.
Deeper tubs are ideal for soaking and relaxation, these tubs are extremely luxurious and provide the perfect place to relax after a long day at work or school. We also offer walk in tubs, which are great for individuals with limited mobility or special needs. | 2019-04-22T10:31:50 | https://www.allglassbath.com/geo/bath-enclosures-kramer-junction/ |
Summary DEACTIVATED 3/15/19 PER Food Literacy & Healthy Lifestyles PT AND ROSE HAYDEN SMITH - Sherry Cooper GBL and school gardens hold great potential for academic and social development for youth. Research has proven that GBL provides a vehicle for improving nutrition, reducing obesity, contributing to positive youth and community development, promoting social development, and increasing academic performance, among other things. There are many models, programs, and products that demonstrate how GBL can help achieve a wide array of educational goals and outcomes, be successfully integrated into other kinds of programs, and serve as rich, multi-disciplinary programs in and of themselves. Our workgroup investigates issues related to gardening with children and the use of gardening as a vehicle for youth education in a variety of disciplines.
4-H Youth Development Advisor Curriculum development, program planning and evaluation aimed directly at youth development. The impact of 4-H on development skills, designing and implementing high quality curriculum that includes the necessity of personal ethics.
"Acting County Director, Nutrition, Family & Consumer Sciences Advisor" | 2019-04-21T16:37:54 | https://ucanr.edu/sites/anrstaff/Divisionwide_Programs/Workgroups/Workgroup_Directory/?thiswg=34 |
Thank you for joining us for our Branding Basics presentation as part of The Treasury’s Premium in Practice series. We had such a great time talking to everyone, and we’d love to learn more about your experience! If you’d like to share with us, please take the brief survey below. Your insight is super valuable to us, and will help us to improve the way we give presentations, teach people, and build useful, educational resources for small business owners.
Thanks again for attending our presentation AND for sharing you feedback with us! Cheers! | 2019-04-18T16:38:19 | http://www.toastoklahoma.com/premium-in-practice-survey |
One of the hot topics of the past few years in American politics, has been that of marriage equality. It’s a debate that’s being waged from the halls of power in Washington, D.C., all the way down to the living rooms and churches of the American heartland. Churches have suffered schisms over the issue of sexuality and gender, and cases which could have a national impact on the topic of marriage equality are currently being deliberated upon by the highest court in the land.
I recently found myself discussing the subject of marriage equality with my father, who is an evangelical Christian and a board member in his local church. Looking back, I’m not at all sure of how the topic came up but there we were, sitting across from each other at the dining room table, discussing exactly what a vote for or against marriage equality was actually about.
My father maintained that he has to vote his conscience, and his conscience tells him that gay marriage is wrong. I, on the other hand, posited that his vote on the issue was not merely a vote for his individual situation, but that it was a vote that affects every single citizen within the purview of the measure being voted upon, whether that be at the local, state or national level. My position was, and still is, that this issue is not a question of should gay marriage be legalized and/or recognized, but one of should people within the LGBT community have the ability to avail themselves of all of the same rights, privileges and protections under the law, that straight people already do?
This is not, as the religious right would argue, a matter of redefining marriage. It is a matter of adhering to and acknowledging the basic concept of what a marriage is; a legally binding contract between two consenting adults.
Neither is marriage the province of the church, or any religious institution. One simple fact bears this out; one cannot obtain a marriage license from a church. For this document, one must consult the county office in which they are entering into the marriage. While it is true that the person officiating the marriage must affix their signature to the document, the document itself is again, filed with the county, not the church.
This is a question of equal rights, and has been all along. Lately, that fact has even been acknowledged by conservative commentators, such as Glenn Beck and Bill O’Reilly who have, in their own ways, affirmed the fact that the conservative base is losing the debate over marriage equality. Their losses are rapidly translating into wins for the LGBT community and all who support them, as evinced by the legalization of marriage equality in Washington, Maryland and Maine in last November’s elections.
The battle is not over, not by a long shot. States such as North Carolina that have enacted legislation abolishing all recognition of marriage equality, will have to be brought before the courts and have those measures deemed unconstitutional, as is currently happening with California’s “Proposition 8.” Cases citing the constitution’s “Full Faith and Credit Clause” will most likely be filed as well. In the end, I would like to think that justice will prevail, and that this nation will live up to the moniker of The Land of The Free. | 2019-04-21T08:23:07 | http://liberalamerica.life/2013/05/06/with-marriage-equality-maybe-were-asking-the-wrong-question/ |
Acne affects young men unconfident, but there are differences ways to care man acne skin care.
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Clearasil for Men - Great looking skin, no extra hassle. Bundle includes: Skin Clearing Shave Gel for Acne-Prone Skin, Multi-Action Hair, Face, and Body Wash, Skin Clearing Aftershave Balm for Acne-Prone Skin, Energizing Acne Scrub for Acne-Prone Skin.
AcnEase has been shown in clinical trials to completely cure 70% of subjects and to be effective in 95% of 15 to 30 years old. AcnEase has also been shown to be highly effective (over 80% response rate) in adults with chronic Adult Acne. AcnEase® is a unique acne treatment that addresses the internal causes of Acne, instead of covering up the external symptoms. Easy to swallow specially coated tablets are safe, and effective in treating both Facial and Body Acne.
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Zeno clears pimples in people with mild to moderate inflammatory acne. It is a hand-held, portable electronic medical device that is clinically proven to make pimples disappear fast.
You will like this kit if you have blemishes, ingrown hairs, break out, black heads or a history of acne. | 2019-04-20T18:53:11 | http://www.skincareinfo.com/men-acne-skin-care.htm |
I have seen it happen to others and laughed. Since it happened to me, it is not as funny. A short time ago, I was looking for my glasses. My vision is not yet opaque, but if I don't have my specs, reading is guess work. I rummaged through my bed side table, investigated the lazy boy chair and frisked every pocket of every coat. Nothing. I bellowed to my wife who looked at me with a smirk.
"Have you tried looking on your face?" Yes, I was wearing my glasses as I hunted for my glasses. (Don't snicker, it will happen to you too!) The irony of using the very thing I was looking for, as I looked for it was not lost on me. After my embarrassment faded I thought of Psalm 36.
The author reminds us that if we are looking for the Light of Truth, we find it by the very truth we are looking for. In other words, our quest for spiritual insight cannot be conducted outside of the enablement of His Spirit. C.S, Lewis paraphrased it this way, "I believe in Christianity as I believe that the sun has risen. Not only because I see it, but because by it I see everything else." He spoke of his spiritual quest as "looking along the beam of light” - not at it. What does this mean practically?
For one thing, it suggests that the way to understand spiritual matters is to experience them. Faith will not be understood from a distance by objective non-committal observations. To understand the Bible, read it. Insight about the church is gleaned as you participate in the community of faith. The only way to grasp prayer is to pray. We see truth by placing ourselves within the truth. There is no other way. We are completely dependent upon the grace of God to enlighten us. Without the mercy of God's enlightenment we are blind and deaf. We are feeling in the dark for our glasses without our glasses.
A second practically affects the way we invite others to the truth. Our appeals, arguments, or warnings seem to bounce off people. Remember, all without God are blind. They can't see what they can't see. Telling them to open their eyes is useless. They can't. But God can. God does. He opens the eyes of the blind by the glorious light of the gospel found in the radiance of Jesus. (2 Cor.3:6) In Jesus truth is found. In Jesus we see the love of God. In Jesus life takes form and shape that can be understood with the lens of eternity.
Maybe it's too close to lunch, but allow me to shift the metaphor from our eyes to our tongues. What's the best way to describe the taste of chocolate? The best way to discover chocolate is not by its recipe or description. Give someone a bite of chocolate and all explanations are superfluous. You know what it is by tasting what it is. So,"Taste and see that the Lord is good." Those who seek God will find God because He is shining their path to Himself. | 2019-04-25T08:37:08 | http://www.bethelmennonitechurch.org/for-pilgrims/godly-optics |
Plans are gathering pace for Bradford’s new City Library with the arrival of a new temporary children’s library in City Park today.
The opening of the new Park and Read facility coincides with National Bookstart Week, the national initiative supported by Bradford Libraries to encourage children to get into books from an early age.
Park and Read, which will be based at City Park’s pavilion, was officially opened by Councillor Ralph Berry, Bradford Council’s executive member for children's services.
The new City Library is due to open in December following the news that repairs to the old Central Library would take too long and cost too much to stay as the main city centre library.
The children's library will have a wide range of books for babies, children and young people – from birth to 16 years – as well as a programme of story times, rhyme times, events and activities.
Youngsters and their parents from children's centres across the district descended on the park in their rain coats for Bookstart’s Ugly Duckling Splash Event.
There were stories and rhymes, an egg hunt, face painting, balloon modelling and inflatable ducks.
Councillor Susan Hinchcliffe, executive member for employment, skills and culture, said: “The new Park and Read will be a great facility for children and young people and ensures they still have access to a library service in the city centre.
“We’re really looking forward to the opening of Park and Read in City Park. It's just the right time of year for it to open. It's a great opportunity for families using the park over the summer to join in with the events in Park and Read.
“It all helps foster that love of reading in children and hopefully encourage them to read more over the summer holidays.
“The project plan for the new City Library is on track. We’ve been working with library staff to make sure that the design of the new library fulfils what our library users have told us they want to see. Our new neighbours, Impressions gallery, have also been really helpful in working with us to achieve the deadline.
Park and Read will run from June to December 2013 (when the new City Library opens) and will be open Monday to Saturday from 9am to 5pm.
Books for adults and computer access are available in the mobile library in City Park, open Monday to Friday from 9am to 5pm until the new library opens. | 2019-04-23T09:02:43 | https://www.thetelegraphandargus.co.uk/news/10513437.new-book-facility-for-children-opens-in-city-centre/ |
In connection with the first media reports of deaths as a consequence of contracting influenza, many people have realised that it would be better to be vaccinated. Unfortunately the vaccine may not work at such a late stage, due to the epidemiology of influenza.
The incubation period of influenza is within the range of one to four days, but the formation of antibodies which provide protection against influenza takes approximately 14 days. A simple mathematical calculation thus tells us that the peak of the epidemic may arrive before we develop immunity to the virus, even with today’s application of the vaccine. If a patient is vaccinated against flu during the period of the epidemic, the vaccine may not provide the expected protection. On the other hand, however, it is not possible to state that the vaccine will be entirely ineffective: effectiveness depends on the length of time during which the organism is exposed to the flu virus after vaccination. As a result doctors recommend that we are vaccinated at the beginning of the season and that only patients in risk groups in individual cases are vaccinated during the time of the flu epidemic. | 2019-04-26T09:44:30 | https://www.czechrelocation.com/blog/14-vaccination-during-flu-epidemic |
This cube test was, for me, pretty worthless. It didn't describe me well at all. Maybe it just tells me I am weird. I immediately pictured a black polished chrome cube about 3 ft cubed floating in mid air rotating slowly on one of its points. The ladder was beneath the cube leading to somewhere below. There were four purple and white orchids at the 4 points of a cross surrounding the slow spinning cube. The horse was a black stallion, regal, strong, and stoic standing at the edge of the room and the rain poured everywhere, not in dismal but in beautiful torrents. | 2019-04-26T03:43:37 | https://www.personality-and-aptitude-career-tests.com/fun-but-inane.html |
Over the weekend, I had two movie choices, An Inside Job, the documentary about the financial crisis or the new Woody Allen film, You Will Meet A Tall Dark Stranger. I chose the former principally because it started in 10 minutes. So much for a relaxing Saturday afternoon.
An Inside Job is not your father’s documentary. The beautiful cinematography and great music have more in common with a mainstream film. On the other hand, the chances of a mainstream film being made on such a difficult subject are nil.
There are two challenges in telling this story. One is that the topic is basically economics-complicated and dry. Director Charles Ferguson tackles this by opening with Iceland’s financial collapse. Although Iceland is a much smaller economy than ours, there are some notable parallels that serve as a smooth segue into our troubles. Ferguson also makes extensive use of graphics that are a bit pedantic, but do adequately explain a credit default swap, for example.
The second problem Ferguson faces is that none of the key players want to talk. In fact, the legions of bankers, politicians, insurance company executives, Federal Reserve officers, regulators, and lobbyists who “declined to be interviewed for this film” far exceeds the ones who would . One needs a few interviews with the leaders in the industry to balance the conversations with the watchdogs, whistle blowers, and contrarians who saw the crisis looming. However, the only wrongdoers that Ferguson could convince to speak on camera are not exactly lynchpins. (Lloyd Blankfein knows better!) It would have been preferable to show additional footage of the Senate hearings where the boys weren’t allowed to dodge the interview, if not the question.
There is plenty of material, however, to make the case that all of this could have been prevented. Furthermore, no meaningful regulation has been enacted to prevent this from happening again. For the big banks, there was a bit of hand ringing, some embarrassing Washington appearances, and fines. But most banks are back on their feet (even if homeowners are not), and the Treasury department and Federal Reserve are still heavily populated with alumnae from those same institutions. It is business as usual.
This fast-paced, visually appealing film provides a good overview, but 129 minutes is not enough time to really delve deeply into the issues. But 129 minutes is more than enough time to make every audience member hopping mad! | 2019-04-21T00:25:12 | http://elizabethcoltonwalls.com/an-inside-job-the-film/ |
Design automation techniques play a major role in VLSI design. Growth in the complexity of circuits and performance requirements has necessitated the use of computer aided design tools. We examine some of the problems faced in the design of high performance synchronous circuits. Synchronous circuits use complex clocking schedules and circuit structures to capture and store data signals. The performance metric is measured by the periodicity of signals in the clocking schedule. The first aspect of this thesis is devoted to the analysis of synchronous circuits. A clocking schedule must satisfy constraints that arise from the circuit topology and delay distribution on gates, wires and memory elements. Analysis to examine if a clock schedule is error-free is first considered. Improving the performance metric without changing the circuit typology the next issue considered. Flexibility in changing the clock signals and borrowing time across level-sensitive memory elements provides ample freedom for improving the circuit performance and should be exploited. The second aspect focusses on performance improvement by transforming the circuit structure. A technique to use existing combinational delay optimizers repeatedly to solve the sequential performance problem is proposed. The approach uses an innovative notion of "perturbation" to extract timing constraints. If the difference between the largest and the smallest delays of paths between a pair of memory elements is significant, the short path can cause erroneous latching of data. This is known as the short path problem. We investigate this problem and propose a solution based on active delay insertion. | 2019-04-26T11:44:27 | https://www2.eecs.berkeley.edu/Pubs/TechRpts/1993/2482.html |
Reviews - Page 7 - Auto Craftsmen LTD.
Thanks for the follow up. Yes, my Tacoma has much more pep and seems to run smoother too. I'm glad that worked out so well and appreciate the pic's of the other problem areas. I must say it was very nice working with you both and I feel you guys care for my truck as much as I do!!!
Very Happy! We are very happy you caught the problem with the gas tank. My mother does not like surprises when it comes to her car. We will definitely use your service again.
Your Service is Invaluable! Just want to drop a line to describe my experience of you and Autocraftsmen while I was shopping for a used car . . . I'm a single gal with a young kiddo and car shopping and buying was not exactly something I was looking forward to. But it was time, in fact, overdue. It took a few weeks and a few conversations with Mark and Amy at Autocraftsmen to finally narrow down my choices for a new (used) car. No matter how many times I stopped by or called, Mark or Amy were always on the receiving side of my inquiries and questions with a ton of tireless respect and care. They either took my call or visit then and there-- or called me back pronto if I left a voicemail. It was clear they were in my corner, genuinely wanting me to get a car that was right for me, safe and reliable. But Amy's most outstanding help arrived when the virtual rubber hit the virtual road. I finally found a car in my price range and that seemingly fulfilled my list of desires - though 200 miles away since I was shopping online for a car south of Vermont. Not only did Amy look over the Car Fax report but she also had a list of things to ask the salesman about the car: to stick a quarter in the tire tread and see how much of George's head could be seen; to ask if the brake rotors had ever been replaced - or just resurfaced; and to ask to have the service records faxed to me. That was when the salesmen began to dodge my calls, not return messages and generally put me off. It was fishy. Even though I had put a $500 deposit on the car, thankfully they eventually refunded it. The good news was that I next found the car of my dreams and in my price range, though again online. Again, Amy reviewed the car fax report and the service records -- and asked those same valuable questions about the brake rotors and tire tread. Everything checked out without a hitch and my car was delivered in less than a week later. Amy went the distance for me and the car of my dreams came from long distance to me. Autocraftsmen crew gave it a 44-point inspection and Mark gladly reported that it was like a 'new' car. I couldn't be happier. Amy, Mark and Autocraftsmen team helped me carry the load of car shopping, made it less stressful and guided the way. Thank YOU Amy, Mark and Team! Your service is invaluable.
Wonderful! While on vacation the check engine light came on. We called Triple A and they recommended your shop. Great directions, fast service, friendly car care and great tips. Thank You.
Trustworthy competent personable. Community minded. Loaner cars and bikes. Great waiting room. They truly are craftsmen.
Best place in town. Honest, reliable, great customer service. A gem. | 2019-04-22T08:18:21 | https://www.autocraftsmen.com/reviews/7 |
How Do I Set My Sprinkler Clock?
The overall goal in watering the plants in your Outdoor Living Spaces should be to promote deep root growth. As the roots grow deeper, you can water less frequently and therefore, conserve water.
I have three post on water scheduling that address the different mistakes made by people when watering the lawn. I recommend starting by reading these three posts and implementing the strategies mentioned in those articles.
After implementing these strategies for one growing season, start next year again by eliminating the syringing, but by reevaluating how often you need to water.
You may even get to the point where you only have to water your lawn once every ten days in the hottest months of the summer depending on your soil type and the microclimate of your lawn areas.
Good luck and save money and water!
Artisan Landscape Outdoor Living Podcast Episode 4.
Conservation in the landscape does not have to mean desertscaping or ‘zero-scaping’ as it is frequently and improperly called. You can have a lush, green Outdoor Living Space and still have the space be very sustainable.
The original term ‘Xeriscape’ was coined in Denver in 1978 after the drought in 1977. Broadly defined, ‘xeriscaping’ means to group plants of like water needs and use more plants with low water needs and fewer plants with high water needs. This is the simplest form of conservation.
‘Zeroscaping’ or ‘Desertscaping’ which is the more correct term for an all rocks, hardscape and cactus landscape, is unappealing to many people, and therefore, people tend to think that you can not conserve in the landscape unless you use all rocks and cactus.
Ironically, though an all rocks, hardscape and cactus landscape uses less water, it also increases the heating and cooling requirements of the structure it surrounds because the micro-climate around the structure is drastically changed.
There are many factors, like heating and cooling, other than water conservation that play a major role in conservation in the landscape. I have come up with a list of seven categories that I will cover in this series of posts and podcasts that will help to give ideas to conserve in the landscape.
These seven categories are: Water, Electricity, Time, Function, Recycling/Pollution, Organice Applications and Energy.
I will include the links to all the posts in this series here at the bottom of this post, but I would recommend starting with the three part watering series called “Three Things You Are Doing to Kill Your Lawn” on the Gardening and Maintenance page. You can also access these posts from the link below “How Do I Set My Sprinkler Clock?”.
I am asked all the time if I know someone that mows lawns, pulls weeds, or does other small yard maintenance and enhancement projects. Now I do–me.
My decision to provide lawn mowing and other gardening services comes as a result of weathering the current economy, but is very good news for all of you out there that have begged me in the past to take care of your yards.
I have avoided this in the past because I knew that if I wasn’t the one to come and actually mow your lawn, I would have to charge way too much for the price to be competitive…so now I am going to come and personally mow your lawn, so you get the eyes of a real expert on your yard each week.
With my eyes on your yard each week, we can start to freshen up the small details that have annoyed you for years and work towards a healthier yard that will look better and better each year.
I will be offering a monthly sprinkler check as an upgrade to your mowing service. With this service, I will be checking for breaks and poor coverage and then implementing the watering strategies I cover in my posts on how to water. Your lawn will be healthier and you will be able to save some money on your water bill in the future.
As well as the sprinkler check, I will be offering pruning, dead heading, and general clean-up services. Proper pruning and dead heading will help your trees, shrubs and perennials to be healthier and produce more and larger flowers and fruit.
Of course I am available for enhancement projects and for other small projects like weeding. I am considering even offering holiday lighting this year, depending on the demand. If I do go forward with the holiday lighting, we will be offering lit, stand-in trees for both the Halloween and the Christmas holidays. Stand-in trees are a secret that Temple Square uses to make their grounds look so beautiful during Christmas.
So, leave a comment below with your contact information and I will get in touch with you. As a note, if you do leave a comment, I will not post your personal information on my website.
Thanks all and happy gardening!
My children spend all of their time around the water feature when they play outside. And I love to leave the window in my bedroom open a crack at night so I can lie in bed and listen to small waterfall.
I have six koi in my pond, and I used to have a turtle in my pond, but we had a problem with her hibernation last winter and she is not with us anymore. The goldfish in the pond are left overs from feeding the turtle, and they have grown quite large now.
A water feature tends to take over as the center piece of your Outdoor Living Spaces, no matter how large or small. Everyone I do a pond for says that the pond is hands down the best addition to their yard.
My back yard is in desperate need of the walls and ceilings for my Outdoor Living Spaces, but I keep running out of time and money.
I have a deck planned and three separate pergolas, only one of which will function as an outdoor room for the table and chairs tucked away by the head of the water feature.
The trees behind my swing will be the ceiling for that little space when they grow up.
I have, however, been able to tuck away several accessories that give the back yard that whimsical feeling that makes us feel comfortable outside. Some of the accessories have been purchased, but others my kids have made, like the gazing balls and the little hidden caterpillars.
I just love to walk across the thyme lawn in my front yard! The scent is heavenly and two of my six varieties of thyme are starting to bloom. The thyme was placed using the same informal flower bed design philosophy as the rest of the yard.
Thyme is a great floor for an Outdoor Living Space. As always, let me know what you think of my front lawn.
The Palmer Residence is a project which incorporates an Outdoor Kitchen, Dining, Hot Tub, and Great Rooms. Click below to check out the design and the before pictures.
The Allen Residence is a flower bed and Outdoor Dining Room that I designed and installed in Hooper, UT and completed late in May 2009. | 2019-04-26T00:32:42 | https://www.artisanlol.com/2009/06 |
I came across KellyButton's sand art terrarium DIY today, and I think it's crafty serendipity since I just received some air plants in the mail last week. Time to make my own painted desert for the bedroom mantle. Check out the details on her blog. | 2019-04-20T05:19:22 | http://www.arrowheadvintage.com/2012/07/sand-art-terrarium.html |
This option requires basic OS understanding. Thank you so much for making my shopping experience a bliss David! Got an email saying estimated ship date was going to be 4th Sept due to some parts of the bundle missing. Other drivers most commonly associated with Aten Uc problems: Get the Latest Deals!
Previous driver cd-roms and driver files downloaded from the internet possibly contain older versions of the driver and applying these drivers uc3224 result in problems during use.
aren He is, a huge asset to this company. She took the time to answer all my questions, reassured me that the components I picked for my build would enable me to accomplish what I planned and always had a great upbeat friendly personality. After initially being advised that the repairs could not be done for a few days there was a change of personnel and I can only say that Tyler Coster absolutely nailed it! Do you own this product? I think I have spent around 15k over the past 12 months and would not be coming back if the service and people were not top notch.
In case you experience connection problems with the Bridgemate Pro server, it is recommended the driver be updated. Dropped off a Kinder Surprise to him in appreciation for his assistance. In some cases, and only where you have given the courier company permission to leave orders at a designated iwndows, your order may be delivered without requiring a signature. Please register, and get one.
Corporate Company Contact us. Other drivers most commonly associated with Aten Uc problems: When these symptoms continuously occur on your computer and as a consequence Bridgemate Control Software cannot be used properly, the driver of the Aten USB-serial converter should be updated.
Shipping costs Shipping costs vary based on your location and the items being shipped and in some cases shipping may even be FREE. I pre-ordered the Samsung Note 9 bundle, expecting it to ship on the 24th.
David has made my experience with PBtech cu2324 wonderful and I wwindows everyone to consult with him when making a purchase: His technical knowledge is amazing and he most certainly raises the bar for me of what I should expect from a sales representative at any retail store. Installation Manager Success Stats: Ask a question which other users may be able to answer.
Sean has looked after my family before, and the reason why we always shop there. Turned out the phone was there and it was the headphones missing. Please help us maintain a helpfull driver collection.
Very lucky to have Tyler in your PB team. Thank you so much for making my shopping experience a bliss David! Once again on a visit to NZ,on January 10th, I had to return to the store as one of the straps had detached.
I am currently travelling but will be in the market for a flatbed scanner printer copier once I return and will most likely order from your company Thanks again”. Dimensions L x W x H Get the Latest Deals!
Unfortunately no pick-up options are available directly from this location, you can select a pick up from one of our branches however and we will transfer your order there so you can aaten up.
Apple Mac iPhone iPad Accessories. At that time I received excellent advice and service from knowledgeable staff. If there is not a suitable product that can be exchanged for your returned item you will be offered a credit on your account sindows gift card based on the value paid at the time of purchase. Tyler is a great role model for technical support service provider. Filter Results Verified Owners Only. | 2019-04-22T20:59:44 | http://c-64.mobi/aten-uc2324-windows-7-17/ |
Nissan Leaf Lost Car Keys Replacement Made Easy! All The Information You Need To Get a New Car Key. Cost, Type Of Keys, Where To Make a Duplicate and More.
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Lost Nissan Leaf car keys – How to get a new replacement key? What options do I have?
Can I get Nissan Leaf key replacement by VIN?
Nissan Leaf was introduced in 2011. This model has three types of keys.
Remote key fob: 2012-2018 – Three types of remotes.
I Lost my Nissan Leaf car keys, have no spare and need a replacement. How and where can I get a replacement key?
First, call an automotive locksmith that offers a mobile service for Nissan Leaf cars. We can help you with that.
First, make sure you have the exact year, make and model, e.g. 2018 Nissan Leaf.
Q: Nissan Leaf key replacement cost – How much does it cost to replace Nissan Leaf key without the original? What is the average price?
Q: Can I get Nissan Leaf key replacement by VIN?
For Nissan Leaf model that are equipped with a transponder system and/or remote/ intelligent key/ fob key: Codes are available. However, programming is necessary and therefore you will have to either tow the car to the dealer or have an automotive locksmith come and program the key on site.
None – All of Nissan Leaf keys are remotes.
CWTWB1G0168, 285E3-3NF4A, OEM# 285E3-1KM0D or 285E3-1KM0A.
Give Us a Call 24/7 and Get 10% Off All Nissan Leaf Lost Car Keys Replacement! | 2019-04-20T17:23:38 | https://lost-car-keys-replacement.com/nissan/leaf/ |
In the last year Instagram has undertook a significant transformation. The popularisation of live video, Snapchat and messaging apps, has driven the social network to change its brand model. In fact, recent innovations from the company have included a Snapchat-like feature (Instagram Stories) and live streaming.
Their latest feature is Galleries. This allows all users to upload up to 10 photos in one post - only previously possible with 4 images through Carousel ads.
The first photo in a gallery appears like any other Instagram post on the main feed. This is with the exception of a small icon in the top right corner. Once clicked on, grey dots appear at the bottom of the photo to inform the viewer they can swipe to see more content.
The mechanics is similar to Stories (with the exception of not disappearing after 24 hours). Yet, will arguably become a more powerful tool in social media marketing.
As stated by Fabrizio Perrone, CEO of Influencer platform Buzzoole, “nothing turns followers off more than radio silence from a user, followed by a huge spam of more than three photos or videos in a row”.
Arguably this is the greatest benefit of Instagram Galleries. You now have the ability to categories all content relating to specific events under one image. This allows brands to share more ‘special moments’ without cluttering their profile or their followers’ feeds.
Fashion brands and publications have obviously been quick to embrace this new social tool. Fendi used it to celebrate the release of their Fall collection, and the launch of their new Sweet Dream window installations. Rather than overwhelming people with photos of these events, the brand tightly packaged their content in a way that intrigues their community to discover more.
Retail company Opening Ceremony tapped into Galleries as a way to celebrate their collaboration with Kenzo for the new Music is My Mistress movie. While i-D magazine have been heavy users of Galleries as a way to highlight new stories (including the launch of Chanel’s The Fifth Sense campaign, and the release of Christopher Raeburn’s new collection) in a more dynamic format.
You also wouldn’t be too hard pressed to imagine how Galleries could be used during Fashion Week shows, surprise product drops and influencer marketing campaigns. However, beyond fashion, Galleries can still be utilised as a way to enhance user experiences. For instance, US restaurant chain Eat Chow and beauty brand Urban Decayboth used the feature to share ‘how-to’ content. This tactic could easily be replicated across multiple industries - from technology to FMCG.
As Instagram product manager Yichen Wang said, “[Galleries] was inspired by members of [Instagram’s] community, who have told [them] that there are times they want to share more than just one moment from a memorable experience in their feed”. Yet, while Galleries may be consumer-driven, it is arguably brands who will be most creative in their use of it.
Last year Instagram introduced an algorithm to organise content in users’ feeds, which they say priorities quality-over-quantity.
Shifting away from a chronological format, the new algorithm delivers users content based on their activity habits. The consequence of this is that brands can’t merely post high volumes of photos to continuously reach eyeballs.
Instagram Galleries would appear to be another step in encouraging brands and users to ‘think-before-they-post’. Rather than approaching Instagram with an ad hoc mindset, brands need to be strategic or risk not reaching their target market.
Content composed with the instant Online HTML editor. Please purchase a HTMLg license to remove the promotional messages from the edited documents. | 2019-04-20T06:38:21 | https://simplicitypartners.co.uk/blog/instagram-galleries-your-new-favourite-social-media-tool/ |
Our former colleague at 99.9 The Fan, Dave Shore, is now with ESPN in LA. He produces the Lakers' radio broadcasts. Dave was working in the Triangle when Rays' pitcher David Price was playing for the Bulls. Dave spotted Price at a Lakers' game earlier this month...nabbed him from the crowd, gave him a headset and put him to work! | 2019-04-18T10:57:05 | http://www.durhambaseballnotes.com/2012/01/david-price-off-season-update.html |
Finding and acquiring prospects is one of the major challenges my existing clients were having. This is in fact, the challenge faced by every marketer who wants to get closer to their prospects and build a successful client-focused business. Most of the times, it’s not because of the lack of efforts, but rather a lack of knowledge of how to use and implement any plan correctly. And yet, there is another big challenge that comes up when looking up “how to get prospects eager to buy from you.” You may easily get intimidated when you see the prospects dragging their feet and you completely failed to earn their trust.
It is a great trick to create urgency in a prospect in an unexpected way. You just need to identify the goals and pain points of your prospect. This will let them better explore the negative consequences of inaction and why moving forward now is critical. You’ve to show them that you’re running out of inventory and how they are losing a good opportunity.
It is no doubt that this idea can be highly effective, but it doesn’t help your prospect recognize the importance of choosing your specific product or service. So there is strong possibility that your prospect will choose your competitor or solve the issue in-house. Hence, if you want to get prospects eager to buy from you, you’ve to help them make purchase decisions faster. You need to show them how your product or service will help them take full advantage, while a rejection will result in an undesirable future.
Sometimes, the length, complexity and the scope of buying process can be inconvenient for your prospects. Thus, put prospects at ease and develop momentum by making everything seamless and manageable. Be simple, clear and precise to make your prospect more comfortable in making a buying decision. For example, it is wrong to tell your prospect to contact you if in case he is interested to know more about your product or service. Instead, provide them with suggestions on how you can plan a strategy at a time that is convenient for them. It’s always better to be proactive than reactive.
It is not a good idea to present your prospects with tons of information at once. Because your prospect will not fully appreciate the benefits of your product or service if they do not get the sufficient time to understand what the product is all about. Your message will lose its impact when it’s all presented at once and your prospect might slow down the buying process while he sorts through the flood of facts you told him. So your focus should be quality, rather than quantity. For instance, rather than presenting several case studies, you should look for the case study featuring the project’s situation most similar to the specific prospect.
This conciseness also applies to emails. Always prepare short and concise messages so as to receive the quick response from your prospect. Or else, your prospect will postpone replying to your message until they have got more time to read it.
If your prospects trust you, they will buy from you. So in order to get prospects eager to buy from you, you need to establish a personal relationship with them and show them they can trust you. Make them realize that they are dealing with an expert. And this is only possible if you have the highest amount of information that can give you a definite edge over your competition. Show your prospect that you genuinely care about their challenges. You also have some great valuable business intelligence or thoughts that can help them overcome that challenge. Sharing a success story from a similar company could also be a good idea.
By showing genuine interest in your prospect’s business, putting their needs first and proving your worth, you’ll be able to build a strong relationship and can actually help you win the trust of your prospect.
Setting yourself apart from the other is always a key to success. Therefore, do not try to get known for everything, instead, try to stand for something specific in front of your prospects. Let’s take an example of my recently launched software, Konneto. It is simple yet effective lead management software and this is what I am using as its USP. As Konneto simplifies the lead tracking in the most effective and hassle free way, it has emerged as one of the fastest growing lead capturing and management platform. Thus, the unique factor- ‘simple yet effective’ made Konneto the first choice among business owners to take control of their incoming leads and land them more leads.
Therefore, the biggest advantage of using Konneto is its simplicity. And this is what makes it stand out from the competition. So, by making a stand and choosing something that makes your product or business unique, you’ve the opportunity to get recognized for that unique proposition. This as a result will help you get prospects eager to buy from you.
Your brand or identity communicates your business personality and shapes the perceptions of your prospects. So it should project the expectations you extend to your prospects in terms of services, quality and reliability. If you have a professional identity which is consistent and is easily reflected in your business cards, social media profiles, website, etc., then your prospects are more likely to do business with you. Like I can give you one example of my client Green Lotus, which has set a new benchmark in providing green housing options in the Tricity region. They came up with a unique initiative #unitedforgreen and are genuinely supporting the cause so as to promote environmental awareness. This campaign is seeing a great response across all platforms- be it online or offline.
Till now, United for Green on Facebook has received approx 4,560 likes. This is how Green Lotus symbolizes the trust and commitment that comes with glorious decades of brand success. Apart from this initiative, it has a separate page on Facebook with more than 64K likes. This shows how being different, thinking for a sensitive cause helps in building a brand identity that makes you stand apart from the rest.
Creating messages targeting your potential prospect could be the best bet for reaching out to them. This will encourage them to complete a specific action. So, know everything about direct response marketing methods if you want to focus more on results that matter. Below is a screenshot of a Facebook ad for one of our clients, Desi Cooks. This enticing ad shows how direct response marketing can help you fetch potential prospects and win more sales.
Such kind of compelling messages can help your ideal prospects understand why they would have to be a fool not to work with you. Furthermore, you can also create ads that offer something valuable and can easily get prospects eager to buy from you.
Traditional selling is always focused on silly little close tactics that are based on pressure. So never use this approach and irritate your prospects. Try to become a welcome guest by sending your prospects a continuous stream of value until they are ready to buy.
This could be in the form of articles, tutorials, case studies or even something that’s related to their area of interest. This helps in building trust and goodwill while positioning you as an expert and educator rather than a marketer.
It could be a really effective way to get prospects eager to buy from you. The noteworthy point here is that you not only convert the prospect into a customer, but also build a solid relationship with them based on value and trust. This makes you the logical choice when it comes time for them to make a similar purchase.
Also Read: how to get more customers with some simple tricks?
It is the most ethical and painless way of selling, as it basically involves trust and an exchange of value.
Always ensure that your marketing efforts are designed to make your prospects feel safe and delivers a remarkable experience for them. This will definitely put you in a position to press your prospects’ buy buttons. Moreover, if you use figures, numbers and percentages, you can turn a good tale into the capture and ultimately get prospects eager to buy from you. | 2019-04-21T22:27:58 | https://www.ajayarora.in/how-to-get-prospects-eager-to-buy-from-you/ |
Simply Fill, Toss In, and Enjoy!
It’s as easy to use as it is to love—and it’s safe for all colours, fabrics, and loads! Simply shake a little (or a lot) into the cap. Then toss the beads into the washer at the beginning of the load, before you start the wash and before you drop in your clothes.
Simply choose one of our Unstoppables scents by itself, or mix and match with your favorite Lenor Fabric Conditioner for a scent profile that’s all your own!
Sick of Odours Sticking Around Your Clothes? Read More. | 2019-04-21T08:46:01 | https://www.lenor.co.uk/en-gb/fabric-conditioner-tips/how-to-use-lenor/how-to-use-in-wash-scent-booster |
MASERU — Judges and other judicial officers must be well paid so that they are not corrupted, a senior High Court judge says.
Justice Semapo Peete said this in a paper he presented at a workshop for jurists by the International Commission of Jurists (ICJ) from July 28-30.
His paper was titled “Reviewing Mechanism to Prevent and Combat Judicial Corruption: the experience of Lesotho”.
In it, Justice Peete says underpaid judges are vulnerable to taking bribes to pass favourable rulings.
Poorly remunerated judicial officers are susceptible to corruption.
“Inadequate or unsatisfactory remuneration of the judicial officers often renders some (certainly not all) very vulnerable to corrupt influence by unscrupulous litigants,” the judge says.
He says appropriate salary structures should be established to attract competent judicial officers and retain those who are already on the job.
Justice Peete’s paper does not talk about specific salary and benefits for judiciary officers in the country but the Sunday Express understands that Lesotho’s judicial officers are some of the lowest paid in the region.
Local judges get almost a fraction of what their South African or Namibian counterparts get per month.
Local magistrates are also paid far less that what their counterparts in the region are earning.
This is the same case with prosecutors, judge’s clerks and registrar who are all qualified lawyers by profession.
A local judge is paid about M25 000 per month (see story on Page 2 for other details on judges’ pay).
This brings their annual salary to about M300 000.
A South African judge was getting nearly M1 000 000 a year per year in 2007. That brought their monthly salary to just over M80 000.
In his paper Justice Peete says the judicial sector can be corrupted if it is under-funded and resourced.
The judiciary should not have to beg for resources from the national treasury: “Tensions and alienation creep in when little or grossly inadequate financial resources are allocated to the administration of justice in the government’s budget — and the judiciary is relegated to the position of a “mendicant” (beggar) in order to keep the court system on an even keel,” he says.
Again Justice Peete mentions no specific examples to the Lesotho situation. But investigations by this paper have revealed that at the moment the High Court and the magistrate’s courts have a serious shortage of basic stationery and money to pay transport and food allowances to witnesses (see related story on Page 2).
This paper also understands that judges don’t have flash disks, cartridges for their printers, pens and printing paper.
Judges are still not getting replacements when their official vehicles break down or are taken for routine service.
Last December this newspaper revealed how Justice ‘Maseforo Mahase was forced to use public transport because the High Court had failed to give her a replacement when her official vehicle broke down.
Other judges were also facing the same plight. Investigations this week revealed that this problem is still persisting although the registrar of the High Court and Court of Appeal ‘Mathato Sekoai says plans are underway to replace the old vehicles.
She says the High Court recently received some money from the treasury to keep it running.
Justice Peete said unscrupulous influence of judges in Africa sometimes comes in the form of political corruption.
He said such a “servile judicial appointee stand forever beholden and in awe of their patrons”.
Such appointees lack independence and true impartiality, he added.
Justice Peete explained that the appointment process of judges can make or break a country’s judiciary.
The judiciary should never be politicised, he warned.
“A judge once appointed should never (be) labelled “…our man…” or “…our woman”.
The judge said there had been recent suggestions that Lesotho’s Judicial Service Commission (JSC) should be more representative to include members of the Law Society, the Faculty of Law at the National University of Lesotho and other stakeholders.
But for this to happen, he says, the constitution should be reviewed.
The JSC is responsible for the appointment of judges.
Currently it is made up of the Chief Justice, the Attorney General, and the chairman of the Public Service Commision and the president of the Court of Appeal.
The Law Society has in the past blasted the constitution of the JSC, arguing that it is not well representative.
Justice Peete said the Directorate on Corruption and Economic Crime is yet to make “its mark in the fight against corruption”. | 2019-04-18T21:22:53 | https://sundayexpress.co.ls/%E2%80%98good-pay-will-keep-rot-from-the-bench%E2%80%99/ |
Welcome friends! Benvenuti! Though please don’t let the name fool you - we’re not only about mums, everyone is welcome! Stick around for everything food (and a little bit of style and sass), family cooking, easy cooking for first time parents (or second, third, fourth… you get the gist), easy ready-in-a-flash food and, because we … Continue reading Welcome friends! Benvenuti! | 2019-04-26T07:44:34 | https://cooking-mummies.com/2018/02/ |
Get high on moisture this Christmas! Inside this 100% natural hemp pouch, you’ll find our hemp heroes, ready to protect and hydrate ultra-dry hands, body and lips. These heavy-duty formulas are enriched with Community Trade hemp seed oil from France and come in a reusable hemp pouch, crafted by our Community Trade partners, Teddy Exports in India. Our Hemp range is so good for dry skin they should make it illegal!
Moisturise with a dollop of creamy Body Protector. Next, protect ultra-dry skin and cuticles with our Hand Cream. Don’t forget to apply the Lip Protector regularly to stay hydrated all winter. | 2019-04-24T12:19:16 | https://www.thebodyshop.com/en-au/gifts/christmas-gifts/hemp-expert-moisture-supplies/p/p003058 |
» Triethyl Citrate contains not less than 99.0 percent and not more than 100.5 percent of C12H20O7, calculated on the anhydrous basis.
B: The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of a similar preparation of USP Triethyl Citrate RS.
Specific gravity 841 : between 1.135 and 1.139.
Refractive index 831 : between 1.439 and 1.441.
Acidity Dissolve 32.0 g in 30 mL of alcohol, previously neutralized to phenolphthalein, add bromothymol blue TS, and titrate with 0.10 N sodium hydroxide. Not more than 1.0 mL is required.
Water, Method I 921 : not more than 0.25%.
System suitability solution Prepare a solution in toluene containing about 30 mg each of USP Triethyl Citrate RS and USP Acetyltriethyl Citrate RS per mL.
Assay preparation Transfer about 300 mg of Triethyl Citrate, accurately weighed, to a 10-mL volumetric flask, dissolve in and dilute with toluene to volume, and mix.
Chromatographic system (see Chromatography 621 ) The gas chromatograph is equipped with an on-column, temperature-programmable injector, a flame-ionization detector maintained at about 275 , and a 0.32-mm × 30-m column bonded with a 0.5-µm layer of phase G42. The column temperature is programmed as follows. Initially the temperature is maintained at about 80 for 0.5 minute, then increased at a rate of 20 per minute to about 220 , and maintained at about 220 for 10 minutes. The injection port temperature is programmed as follows. Initially the temperature is maintained at about 85 for 0.5 minute, then increased at a rate of 20 per minute to about 225 , and maintained at about 225 for 10 minutes. The carrier gas is helium, flowing at a rate of about 2.3 mL per minute. Chromatograph the System suitability solution, and record the peak responses as directed for Procedure: the relative retention times are about 0.9 for triethyl citrate and 1.0 for acetyltriethyl citrate; the resolution, R, between triethyl citrate and acetyltriethyl citrate is not less than 1.5; and the relative standard deviation for replicate injections is not more than 2.0% determined from both the triethyl citrate and acetyltriethyl citrate peaks, based on area percent calculation.
in which A is the triethyl citrate peak area response; and B is the sum of the area responses of all the peaks. | 2019-04-21T04:26:06 | https://www.drugfuture.com/Pharmacopoeia/USP32/pub/data/v32270/usp32nf27s0_m85235.html |
"Bill Kennedy" is chief technical officer of MobileRobots, Inc. When not hacking new HTML pages or writing about them, "Dr. Bill" (Ph.D. in biophysics from Loyola University of Chicago) is out promoting the company's line of mobile, autonomous robots that can be used for artificial intelligence, fuzzy logic research, and education.
"Chuck Musciano" began his career as a compiler writer and crafter of tools at Harris Corporations' Advanced Technology Group and is now a manager of Unix Systems in Harris' Corporate Data Center. | 2019-04-23T18:06:36 | https://www.pdfstall.online/2018/11/html-xhtml-definitive-guide-sixth.html |
FEP16C005 Description:Supplier for board level electronic components including FEP16C005. Fast free price and delivery quote, buy online. Millions of parts in Stock. Same Day Ship.
Search Description:Supplier for board level electronic components including FEP16C005. Fast free price and delivery quote, buy online. Millions of parts in Stock. Same Day Ship. | 2019-04-25T02:26:30 | http://core-ic.com/FEP16C005 |
As student Delhi summer used to be gruesome, yet fun and innovative. I wanted to share how I beat those gruesome Delhi heat. We didn't have AC, Cooler nor Fridge to cool off, so what most of us did those days was get cold water from people who have fridge and wrapped the bottle with wet old clothes. This helped in keeping the water cool for a longer time. Some people also used earthen pot, but i did the wrapping bottle way.
At night when its too hot to sleep, I used to pour water from the bucket to the floor - to let evaporation do the cooling. If this didn't work, I sometime dipped my shirt in water and wore them.
This is how we beat the heat those days. Nowadays, student have AC. Cooler and fridge to their comfort, but our experience were priceless and memorable. I am sure some of you would relate to this. | 2019-04-24T07:52:03 | http://ginzavualzong.com/blog/13-how-i-beat-the-heat-as-student-in-delhi-university.html |
Mission: SquashSmarts is dedicated to improving the lives of underserved youth from Philadelphia public schools by providing intensive, long-term academic tutoring and squash instruction, while imparting high standards of personal integrity, health and fitness, and service to the community.
SquashSmarts students are selected in 6th-8th grades based on commitment, effort and attitude, not athletic or academic ability. Students are recruited in 6th-8th grade from our three partner middle schools: Roberto Clemente Promise Academy, Mary McLeod Bethune Elementary, and Overbrook Educational Center. Operating out of two facilities, the Lenfest Center (North Philadelphia) and Drexel’s Daskalakis Athletic Center (West Philadelphia), students attend practices three days each week focusing on SquashSmarts’ Five Pillars: (1) Academic Support, (2) Squash Instruction, (3) Fitness and Nutrition, (4) Personal Achievement, and (5) Leadership. Students also participate in competitive squash opportunities, community service projects, cultural outings, and special events. | 2019-04-22T22:04:08 | http://www.squashsmarts.org/about.html |
Shrove Tuesday is upon us, thankfully the first sign that spring is coming is here. So what is it all about why do you spend the day eating pancakes? Lent is a time of abstinence, so it has been tradition to have one last chance to indulge yourself, traditionally pancakes would have been made to use up the food not allowed during this period, which included fat, butter & eggs.
Now it seems that we go out of our way to purchase the ingredients to make pancakes (that is the fun of it, attempting to make edible pancakes while also trying to minimise how many fall on the floor), or buying shop bought pancakes. Though, the real question on everyone's lips is: What topping would you like on your pancake or crepe (depending how well they have turned out)?
Whether you are into healthy or sweet toppings we have a great selection, there should be 1 to suit everyone's taste. All these products can be found on our Create Your Own Gift Basket site.
Comment below if we have missed out your favourite topping! | 2019-04-20T02:16:29 | https://basketsgalore.co.uk/blog/2015/02/celebrate-shrove-tuesday-in-style-with-baskets-galore/ |
The Connectivity Map (CMAP) database, an important public data source for drug repositioning, archives gene expression profiles from cancer cell lines treated with and without bioactive small molecules. However, there are only one or two technical replicates for each cell line under one treatment condition. For such small-scale data, current fold-changes-based methods lack statistical control in identifying differentially expressed genes (DEGs) in treated cells. Especially, one-to-one comparison may result in too many drug-irrelevant DEGs due to random experimental factors. To tackle this problem, CMAP adopts a pattern-matching strategy to build “connection” between disease signatures and gene expression changes associated with drug treatments. However, many drug-irrelevant genes may blur the “connection” if all the genes are used instead of pre-selected DEGs induced by drug treatments.
We applied OneComp, a customized version of RankComp, to identify DEGs in such small-scale cell line datasets. For a cell line, a list of gene pairs with stable relative expression orderings (REOs) were identified in a large collection of control cell samples measured in different experiments and they formed the background stable REOs. When applying OneComp to a small-scale cell line dataset, the background stable REOs were customized by filtering out the gene pairs with reversal REOs in the control samples of the analyzed dataset.
In simulated data, the consistency scores of overlapping genes between DEGs identified by OneComp and SAM were all higher than 99%, while the consistency score of the DEGs solely identified by OneComp was 96.85% according to the observed expression difference method. The usefulness of OneComp was exemplified in drug repositioning by identifying phenformin and metformin related genes using small-scale cell line datasets which helped to support them as a potential anti-tumor drug for non-small-cell lung carcinoma, while the pattern-matching strategy adopted by CMAP missed the two connections. The implementation of OneComp is available at https://github.com/pathint/reoa.
OneComp performed well in both the simulated and real data. It is useful in drug repositioning studies by helping to find hidden “connections” between drugs and diseases.
There are many strategies for drug repositioning based on different data such as chemical structural similarities, genetic variation (SNPs-disease correlations, SNPs-drug response) and gene expression profiling . The strategy based on gene expression profiling has the advantage that it does not require a great amount of a priori knowledge on the diseases or drugs [2–4]. An ideal database of gene expression profiles for drug repositioning study should include gene expression profiles of many cell lines representing a diverse range of diseases before and after drug treatments usually for thousands of drugs or candidate drugs. Thus, to create such a data source is a huge project and very costive. As far as we know, currently there are only two such large databases . One is the LINCS database, which, however, has only profiled 978 genes for 25,581 drugs, and the other is the CMAP database which has profiled more than 12,000 genes on mainly three types of cancer cell lines, MCF7, PC3 and HL60, treated with 1309 bioactive small molecules at various concentrations . As an important public data source, the Connectivity Map (CMAP) [3, 6] has been widely applied to study drug repositioning [2, 7, 8] and drug action mechanisms [9, 10]. It has been cited over 940 times in the past 10 years, as shown in the PubMed Central database. However, in the CMAP project, usually only one drug-treated sample was measured for one drug concentration against several control samples. For such small cell line datasets, traditional statistical methods such as the significance analysis of microarrays (SAM) [11, 12] and Student’s t test lack power in identifying differentially expressed genes (DEGs) in the treated cells, while the commonly used fold-change (FC) method with an arbitrary cut-off value [14–16] lacks statistical control and tends to get many false discoveries. Therefore, for drug repositioning studies, CMAP adopts a rank-based pattern-matching strategy to build “connections” between disease signature and all gene expression changes caused by drug treatments. However, if all the genes are used, many drug-irrelevant genes participating in building the “connection” may blur the “connection”. Therefore, it is necessary to screen treatment-related DEGs beforehand.
In contrast to the small number of treated samples, there are in total 492, 277 and 229 gene expression profiles of control samples, respectively, for MCF7, PC3 and HL60, which scatter in different experimental batches of CMAP and there are more available in other data sources. Thus, it would be desirable to exploit these valuable control data to aid the differential expression analyses of small-scale treated samples. However, gene expression profiles from different experimental batches or laboratories cannot be directly compared with each other due to experimental batch effects [17, 18]. In addition, different factors such as culturing with drug vehicles, transfecting with control siRNAs or just blank controls may also influence gene expression profiles of a cell line. Recently, we developed an algorithm, RankComp , to identify DEGs in an individual cancer tissue through comparing the relative expression orderings (REOs) within a disease sample with the highly stable REOs predetermined in a large collection of normal samples. The algorithm finds up-regulated and down-regulated genes which lead to the disrupted REOs of gene pairs in the disease sample .
In this study, by analyzing the gene expression profiles of three types of commonly used cancer cell lines, HepG2, HCT116 and MCF7, we show that the REOs of genes pairs are highly reproducible in the control samples of a particular cell type, even though these samples were collected from different laboratories with different cultivation conditions, but widely disrupted after certain treatments. Based on this observation, we adapted RankComp to datasets with only one technical replicate. The modified algorithm, named OneComp, was evaluated based on data of three cell lines. To demonstrate the usefulness of the OneComp algorithm, we applied it to an application case study on repositioning two drugs, phenformin and metformin, for NSCLC based on the CMAP database.
Control samples of human cell lines HepG2 for liver cancer, HCT116 for colorectal cancer and MCF7 for breast cancer from different laboratories were collected to build a background gene pairs (Fig. 1). Three datasets, GSE41326 for HepG2, GSE7161 for HCT116 and GSE37820 for MCF7 were used to evaluate the performance of OneComp (Table 1). All the above datasets were collected from GEO [22, 23] (http://www.ncbi.nlm.nih.gov/geo/) and ArrayExpress (http://www.ebi.ac.uk/arrayexpress/) databases. For the drug-repositioning study, two non-small-cell lung carcinoma (NSCLC) sample datasets [25, 26] (GSE7670 and GSE10072) were used to build the “query signature” and disease signature for NSCLC (Table 2). A large number of control samples for MCF7, PC3 and HL60 cell lines were collected from CMAP database (Table 2) to build the background stable gene pairs. Datasets of metformin and phenformin treated samples for MCF7, PC3 and HL60 cell lines along their control samples were collected from the CMAP database (Table 3) to build the drug signatures.
For all the data we used, we downloaded the raw data (.CEL files) and used RMA (Robust Multichip Average) for background adjustment (Bioconductor Affy package). Probe IDs were mapped to Entrenz gene IDs using the corresponding platform files. If a probe set was mapped to multiple or zero genes, the data of this probe set were discarded. If multiple probe sets were mapped to the same gene, the expression value for the gene was summarized as the arithmetic mean of the values of the multiple probe sets.
where k denotes the total number of control samples, s denotes the number of samples that have a certain REO pattern (e.g., A > B or A < B) in k normal samples, and p e (p e = 0.5 here) is the probability of observing one of two REO patterns in a normal sample by chance. For the multiple binomial tests, the P values are adjusted by the Benjamin and Hochberg method to control the false discovery rate (FDR) .
We defined a consistency score to quantify the consistency between two lists of stable gene pairs separately identified from two independent collections of control samples measured by different laboratories for a cancer cell line. For two lists of stable gene pairs, if there are k overlapping gene pairs among which s pairs show the same REO patterns, the consistency score is the ratio, s/k. The probability of observing a consistency score of s/k by chance is evaluated by the binomial distribution model .
The OneComp method is a customized version of RankComp adapting to one-to-one sample comparison where the original RankComp algorithm fails to identify reliable DEGs, as demonstrated in “Results” section. The major change in OneComp for applications in one-to-one sample comparison is that the selection of gene pairs with stable REOs in the control samples. In RankComp, those gene pairs which have significantly stable REOs in the control samples are selected as the background gene pairs. In OneComp, a list of background gene pairs, which are significantly stable in the collected control samples, are selected and archived for a particular cell line beforehand. Given a pair of control sample and treated sample, each with only one replicate, the prebuilt background gene pairs are screened to exclude those pairs whose REOs are not kept in the current control sample. The remained stable gene pairs are called the customized background gene pairs which are further compared with the treated sample to obtain concordant pairs and reversal pairs.
The following steps are the same as RankComp . Briefly, in a treated cell, the gene pairs which have an opposite REO pattern with the customized background stable gene pairs are defined as the reversal gene pairs. For gene A, if its expression level is lower (or higher) than the expression level of gene B in the customized background gene pairs but opposite in the treated sample, then this reversal gene pair is supposed to support the up-regulation (or down-regulation) of A in the treated sample. Fisher’s exact test is used to test the null hypothesis that the frequency of reversal gene pairs which support the up-regulation of gene A in the treated sample is not different from the frequency of reversal pairs which support the down-regulation of gene A in the treated sample. When the null hypothesis is rejected, gene A is judged to be up- or down-regulated in the treated sample compared with the control sample if the frequency of reversal pairs which support the up-regulation of gene A in the treated sample is higher or lower than the frequency of reversal pairs which support the down-regulation of gene A in the treated sample.
The C-language implementation of OneComp and the original RankComp method is available at https://github.com/pathint/reoa .
The performance of OneComp was evaluated based on three large datasets of HepG2, HCT116 and MCF7 cell lines. For each cell line, we collected a large dataset with several technical replicates of both the control and the drug-treated groups and identified DEGs with SAM. OneComp was applied to identify DEGs from the subsets of the large dataset, each with only a pair of control and treated samples, which were evaluated through comparing with the DEGs identified by SAM in the full large dataset. Those DEGs exclusively identified by OneComp were further evaluated according to the observed genes expression dysregulation directions (up- or down-regulations) between the treated and control samples in the subsets.
The consistency score was also used to quantify the consistency between two lists of DEGs. For two lists of DEGs, if there are k overlapping DEGs among which s genes have the same dysregulation directions (either up or down), the consistency score is the ratio, s/k. The probability of observing a consistency score of s/k by chance is evaluated by the binomial distribution model .
We defined a drug-disease reversal score to reflect the therapeutic effectiveness of a drug to NSCLC based on the hypothesis that the dysregulation directions of the DEGs in the disease signature tend to be reversed after drug treatment if the drug is therapeutically effective to the disease . If k is the number of disease signature genes overlapping with the drug signature genes, among which s genes could be consistent with drug treatment, then the drug-disease reversal score is defined as (1 − s/k). The probability of observing a drug-disease reversal score by chance is evaluated by the binomial distribution model .
In CMAP, without the preselection of DEGs induced by a drug treatment, a complex drug-disease scoring scheme is used to evaluate the connection between a drug and a disease, basically based on the same hypothesis as for the reversal score. Readers are advised to see the CMAP website (https://portals.broadinstitute.org/cmap/) for the definition of the score.
We used the GO-function algorithm , which is based on the cumulative hypergeometric distribution model, to detect non-redundant GO terms that are significantly enriched for the genes of interest.
Based on the PPI data downloaded from SIGNOR Database , the PPI network was built by Cytoscape .
As a basis for the applicability of OneComp in the small-scale cell line experiments with only one or two technical replicates, the stability of REOs of gene pairs was evaluated within technical replicates measured by different laboratories for a particular cell line. We collected a total of 102 control samples of HepG2 cell line measured by 24 laboratories which had different cultivation environments (Fig. 1). We randomly divided the datasets from 24 laboratories into two groups each with 12 laboratories’ datasets referred as group1 and group2 (Fig. 1). Then, 190,294,354 and 189,922,833 gene pairs were identified from group1 and group2, respectively, with significantly stable REOs (binomial test, FDR < 1%). Between the two lists of gene pairs, there are 182,886,518 overlapping gene pairs, approximately 96% of the stable gene pairs detected in either group, and more than 99.92% of the overlapping gene pairs also have the same REOs (binomial test, P < 1.0 × 10−16) (Fig. 1).
Similar results were also observed for the HCT116 and MCF7 cell line samples measured by different laboratories (Fig. 1). These results demonstrate that the significantly stable REOs of gene pairs are highly reproducible across control samples measured by different laboratories for a particular cell type.
Based on the above finding, we applied the RankComp to cell data with only one technical replicate. Taking HepG2 cell lines as an example, we identified 194,730,608 gene pairs with significantly stable REOs (binomial test, FDR < 1%) from 102 control samples available in GEO or ArrayExpress, defined as the background gene pairs (Fig. 1). To mimic the data with only one technical replicate, we divided a large dataset (GSE41326) with three pairs of technical replicates for HepG2 transfected with RNF43 siRNA and negative control into three sub-datasets, each with a pair of treated and control sample. Without using the control sample in each of the subsets to filter the background stable gene pairs, RankComp identified 13,566 DEGs on average in the three sub-datasets. However, the average consistency score between the dysregulation directions (up- or down-regulation) of the identified DEGs and the dysregulation directions observed between the treated and control cells is only 57.37%, which indicates a large false positive rate. Similar results were observed for the comparison studies on GSE7161 and GSE37820, the datasets for the HCT116 and MCF7 cell lines, respectively (Fig. 2a). Thus, RankComp is not suitable for datasets with only one sample, indicating that the significantly stable REOs of gene pairs identified across the control samples measured by different laboratories might be still unable to completely exclude the influences of different cultivation environments (Fig. 1).
Therefore, we customized the background stable REOs by filtering out the gene pairs with reversal REOs in the control sample(s) of the analyzed datasets (see “Methods”). This customized version of RankComp is called OneComp. To evaluate the performance of OneComp, we used the DEGs identified by SAM in the above-mentioned three large datasets as a “gold standard”. With FDR < 5%, SAM identified 1896 DEGs in the full GSE41326 dataset while OneComp identified 5247 DEGs on average in the three paired subset samples of GSE41326, which included 56.91% (1079) of the DEGs identified by SAM. Almost all of these overlapping DEGs detected by SAM in the full dataset and by OneComp in the subsets, the consistency scores (see “Methods”) are all higher than 99% (binomial test, P < 1.0 × 10−16) (Table 4). There are 817 DEGs identified by SAM but not by OneComp, which tend to be those without sufficient expression changes to disrupt REOs. The number of DEGs solely detected by OneComp is much larger, 4168, on average. When the FDR threshold was increased to 20% for the SAM method, 791 of the 4168 DEGs were identified by SAM (Additional file 1: Table S1). This clearly reflects the very low statistical power of SAM when applied to small-scale cell line data sets. The remained DEGs solely identified by OneComp for the three paired samples were further evaluated according to the observed expression difference method. The average consistency score is 96.85% which indicates the dysregulation directions identified by OneComp are mostly correct (Additional file 2: Table S2).
Similar results were observed for the comparison studies on GSE7161 and GSE37820, the datasets for the HCT116 and MCF7 cell lines, respectively (Table 4, Additional file 1: Table S1, Additional file 2: Table S2). These results suggest that OneComp can be reliably used to detect DEGs in cell line data with only one technical replicate.
If two or more three control samples were used for the background filtering, the number of detected DEGs decreased and the average consistency score remains to be close to 100% with a slight increase (Fig. 2b), which indicates that it would be sufficient to use only one control sample to remove the inconsistent background REOs.
The influence of the sample size in building the background gene pairs was also evaluated on the performance of the algorithm using the above three datasets. From the 102 control samples for HepG2, we randomly extracted subsets of different sample sizes ranging from 20 to 102 with a step size of 20. For each sample size, other than 102 for which all the controls were included, the random sampling experiment and the followed analysis were repeated 100 times. As shown in Fig. 2b, when the control sample size increases from 20 to 102, the average number of detected DEGs increases from 4331 to 5247 gradually, and meanwhile the average precision increases slightly from 96.17 to 97.84%. The same trend was observed for HCT116 and MCF7 (Fig. 2b). These results suggest that the performance of OneComp improves as the background control sample size increases (Fig. 2b). However, when the background control sample size is greater than 40, the performance gain is minor, suggesting a suitable lower bound of control sample size for building the control REOs background.
It was reported recently that antidiabetic biguanide drugs such as phenformin and metformin have therapeutic potential to treat NSCLC [34–37]. Here, we analyzed whether there exists a “connection” between biguanides based on DEGs induced by the drug treatments and NSCLC. As a comparison, the approach recommended by the CMAP project was also used to analyze the “connection” [3, 6].
According to the CMAP approach, a “query signature” which includes 10–500 of both up- and down-regulated probe sets should be built first. Using SAM with FDR < 5%, we found 8480 differentially expressed probe sets between NSCLC and lung normal tissues reproducibly in GSE7670 and GSE10072 measured on the HG-U133A platform. Among the differentially expressed probe sets, 641 probe sets were selected with a fold-change (FC) value larger than 2 in both the datasets as the “query signature” of NSCLC. We used this “query signature” to search drugs which have links with NSCLC in the CMAP database through the CMAP portal website (https://portals.broadinstitute.org/cmap/). The results showed that none of the mean drug-disease scores between NSCLC and phenformin were significant (Table 5), providing no support for the therapeutic potential to NSCLC. None of the drug-disease scores between NSCLC and metformin were significant either (Table 5). However, the drug signature used in the CMAP-recommended approach is a list of genes which were obtained according to their fold-changes of gene expressions in the drug-treated sample versus the control sample, which tend to include a large proportion of genes which are irrelevant to drug treatment . This problem may blur the “connection” between the drugs and the disease (Fig. 3).
Therefore, we attempted to reduce the influence of the irrelevant genes by focusing on the DEGs induced by drug treatment when assessing the “connection”. Using the HL60, MCF7 and PC3 control samples scattered in different experimental batches of CMAP (Table 2), we identified a list of gene pairs with significant stable REOs (binomial test, FDR < 1%) for each of the three cell lines. If a cell type was measured on different platforms, stable REOs were detected separately for each platform, and the consistent REOs across platforms were used as the final background REOs landscape . With the background landscape, OneComp was used to identify DEGs for each of the phenformin-treated samples with FDR < 5% (Table 5). For each of the three cell types, a common drug signature was defined as the DEGs that have the same dysregulation directions in at least two samples treated by phenformin with different doses. Furthermore, we mapped the aforementioned 8480 probe sets to 5760 genes using the corresponding platform files and considered these genes as the disease signature. The reversal scores were calculated between the disease signature and the drug signatures (see “Methods”). The reversal score between the NSCLC disease signature and phenformin drug signature is 0.6094 for MCF7 cell line and 0.6053 for PC3 cell line, which are significantly higher than expected by random chance (binomial test, P < 0.0001 and 0.0023, respectively) (Table 5). Similarly, we observed that all of the three reversal scores between metformin and NSCLC were significant (Table 5). The results indicates the therapeutic potential of both phenformin and metformin to NSCLC, and this conclusion is supported by a few previous studies [34–37].
The NSCLC disease signature in this study was obtained from the lung adenocarcinoma (LUAD) samples since LUAD is the main subtype of NSCLC. To evaluate the influence of disease stages on the drug-disease reversal score, we analyzed two groups of the NSCLC samples according to their therapeutic methods [39, 40], stage II to IIIA mainly treated by surgery combined with chemotherapy, and stage IIIB to IV treated by chemotherapy only. For the six drug-disease reversal scores obtained for the two drugs based on three types of cell lines, five scores support the therapeutic potential of the drugs to the stage II to IIIA patients (P < 5%). For the stage IIIB to IV patients, four of the six scores support the therapeutic potential of the drugs (Additional file 3: Table S3). These results suggested the therapeutic potential of phenformin and metformin to NSCLC patients at different stages, although slight differences might exist.
If the DEGs up- or down-regulated in the disease signature could be reversed by the drug treatment, they were defined as the drug-target disease genes for the drug. Based on the two list of drug-target disease genes for phenformin and metformin identified from MCF7, which showed the most significant P values, we explained the possible anti-NSCLC mechanisms of the two drugs, respectively, through gene ontology (GO) enrichment analysis and protein–protein interaction (PPI) network analysis. The 761 drug-target disease genes for metformin were enriched in six functional categories of GO (hypergeometric distribution model, FDR < 5%), including cell cycle, DNA replication, chromosome condensation and other key cellular processes as described in Additional file 4: Table S4. We further built a one-step protein–protein interaction (PPI) network for these 761 DEGs. As show in Fig. 4a, the top five hub-genes with the highest degrees in the network were MAPK1, MAPK14, PPARGC1, SRC and AKT1 which mainly function in proliferation, cell growth and energy metabolism. The 298 drug-target disease genes associated with phenformin were enriched in no pathway (hypergeometric distribution model, FDR < 5%). This may be due to too few genes. By controlling P < 5% instead of FDR < 5%, 16 significant GO functional categories were found which include cell proliferation, cell cycle and other cellular processes as described in Additional file 5: Table S5. Similarly, PPI network analysis showed that the top five hub-genes (MAPK9, PPARG, CHEK1, TP53 and CDK1) are mainly involved in proliferation and cell cycle (Fig. 4b), too. The above results indicate that phenformin and metformin may have therapeutic potential through suppressing the proliferation, growth and energy metabolism of the NSCLC cells [41, 42].
We demonstrated that the REOs of gene pairs are highly stable in control samples measured in different laboratories for a particular cell line. Thus, it is feasible to build a stable REO background landscape for a particular cell line using a large collection of control samples previously measured in different laboratories. For applications to small-scale cell datasets, the stable REO background is customized by filtering out the REOs which are not kept in the control sample(s) of this dataset. Then, OneComp can be used to identify DEGs effectively with statistical control with the customized stable REOs background. Through the analysis on phenformin and metformin treated samples, we showed that the detected DEGs in small-scale cell data with only one or two technical replicates are valuable in the studies for drug repositioning.
Nevertheless, there are also several inherent limitations to use the proposed method for the analysis of small datasets. Although the average consistency scores of the overlapping DEGs between every two technical replicates within GSE41326 are up to 98.20% which indicated that these DEGs with the same dysregulation directions should be true dysregulated genes, there are 42.54% of DEGs on average that were detected in only one technical replicate. The average consistency score of non-common DEGs is only 43.45% if we compare these DEGs identified in one subset with the observed expression difference directions in another subset. This suggests that approximately 32.46% of the overall dysregulated genes detected in one subset of GSE41326 may be unrelated to the biological state of our interest. Similar results were also observed for the GSE7161 and GSE37820 datasets (Additional file 6: Figure S1). Fortunately, based on the assumption that an effective drug should be able to counterbalance the perturbations caused by a disease [3, 6], these unrelated genes will not disturb drug repositioning study deeply in searching the connection between a drug signature and a disease signature. In fact, our method has made much progress compared to the method recommended by the CMAP project as it tends to delete most of the drug unrelated genes (Fig. 3).
In the application case study for drug repositioning, the drug-disease reversal score was used in our method to quantify the connection between a disease signature and a drug signature. An ideal drug repositioning model should use the disease samples in restrictive stages and subtypes to produce the disease signature and use the cell lines corresponding to the disease tissue types to produce the drug signature. However, because the drug treatment profiles in CMAP were performed only on MCF7, PC3 and HL60 cancer cell lines, we used the three drug-signatures separately identified from the drug-treated MCF7 (for breast cancer), PC3 (for prostate cancer) and HL60 (for promyelocytic leukemia cancer) cell lines for each of the two biguanide drugs (phenformin and metformin) to infer the “connection” between the drugs and NSCLC. The underlying hypothesis behind the CMAP project is that there are similar (or significantly overlapped) changes in the gene expression profiles of cell lines obtained from different cancer types exposed to the same drug. Here, we observed that, based on the data for three types of cancer cell lines, two of the three reversal scores between phenformin and NSCLC and all of the three reversal scores between metformin and NSCLC were significant (P < 1%), supporting the therapeutic potential of both metformin and phenformin to NSCLC. This also indicates a high consistency between the drug-signatures from drug-treated MCF7, PC3 and HL60, partially supporting the above-mentioned hypothesis. Nevertheless, this hypothesis needs to be fully addressed by evaluating whether the drug-signatures identified from multiple cell lines for different diseases or the same disease are significantly overlapped if treated by the same drug.
In this study, we revealed that REOs of genes pairs are highly reproducible in the control samples of a particular cell type. Based on this finding, we customized the RankComp method to the application scenario of identifying DEGs in small-scale cell line experiments with only one or two technical replicates. The method performed well in simulated small-scale cell datasets. Using the DEGs identified by OneComp between antidiabetic biguanide drugs (phenformin and metformin) treated samples and corresponding control samples, we built “connections” between biguanides and NSCLC. The “connections” are statistically significant and support biguanides as potential anti-tumor drugs for NSCLC, while the pattern-matching strategy adopted by CMAP missed these “connections”. Therefore, OneComp method is useful in drug repositioning studies by helping to find more hidden “connections” between drugs and diseases.
ZG, JH and HDY conceived and designed the overall study. JH, HC, XYL and QZG performed the computational experiments. KS, WCZ, HPL, and RC participated in study design. JH, XLW and ZG wrote the manuscript. All authors read and approved the manuscript.
All the data are available at public GEO, ArrayExpress and CMAP database according to their corresponding accession numbers mentioned in the “Methods” section.
All the authors in this paper consent to publication of the work.
The data is derived from public GEO, ArrayExpress and CMAP database, where the ethical issues had already been addressed.
This work was supported by National Natural Science Foundation of China (Grant Numbers: 81372213, 81572935, and 21534008) and the Joint Scientific and Technology Innovation Fund of Fujian Province (Grant Numbers: 2016Y9044).
12967_2017_1302_MOESM1_ESM.docx Additional file 1: Table S1. Overlap of DEGs detected by SAM (FDR < 20%) and OneComp.
12967_2017_1302_MOESM2_ESM.docx Additional file 2: Table S2. The consistency of remained DEGs solely identified by OneComp.
12967_2017_1302_MOESM3_ESM.docx Additional file 3: Table S3. Drug-disease reversal scores of the drug repositioning for phenformin and metformin for LUAD in different stages.
12967_2017_1302_MOESM4_ESM.docx Additional file 4: Table S4. The result of GO gene ontology enrichment of the 761 reversed associated with metformin (FDR < 5%).
12967_2017_1302_MOESM5_ESM.docx Additional file 5: Table S5. The result of GO gene ontology enrichment of the 298 reversed associated with phenformin (P < 5%).
12967_2017_1302_MOESM6_ESM.tif Additional file 6: Figure S1. DEGs overlapping between every two paired technical replicates within GSE41326, GSE37820 and GSE7161. Blue pie represents the DEGs of one paired technical replicates, red pie represents the DEGs of another paired technical replicates. The overlap in the pie represent common DEGs detected in both the two paired technical replicates and the number in the brackets in the overlapping region represent the consistency score, which denotes the percentage of DEGs that display the same dysregulated direction between common DEGs detected in both the two paired technical replicates. The number in the brackets in the blue region represent the consistency scores by using the observed expression differences (up- or down-regulations) between paired treated and control technical replicates in red region as the benchmark to evaluate the DEGs of the blue region paired samples. Similarly, The number in the brackets in the red region represent the consistency scores by using the observed expression differences (up- or down-regulations) between paired treated and control technical replicates in blue region as the benchmark to evaluate the DEGs of the red region paired samples.
Relative Expression Ordering Analysis (REOA) package. https://github.com/pathint/reoa. Accessed 27 Mar 2017. | 2019-04-23T01:54:50 | https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1302-9 |
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Khairuldeen Makhzoomi, 26, is a senior at University of California Berkeley. Makhzoomi lives with his mother and younger brother in Oakland. His father was an Iraqi diplomat whom Saddam Hussein jailed in Abu Ghraib prison. The dictator’s regime later killed him.
On April 6, Makhzoomi boarded a Southwest Airlines flight at LAX that was headed for Oakland. After boarding, Makhzoomi called an uncle in Baghdad to tell him that he had just heard United Nation Secretary General Ban Ki-moon deliver a speech.
Makhzoomi told his uncle that he asked the secretary general a question about ISIS. The conversation ended with the Arabic phrase, “inshallah” or god willing.
A female passenger in a seat nearby overheard the conversation and told the flight crew she heard him making potentially threatening statements.
The Southwest employee then escorted him off the plane, and Makhzoomi accused the employee of anti-Muslim bias.
Law enforcement officials searched Makhzoomi in the airport terminal in front of a crowd of onlookers, including other officers and a police dog. Three FBI agents then arrived and questioned him in a private room.
Makhzoomi said an FBI agent told him the Southwest Airlines employee said a passenger reported hearing him talk in Arabic about martyrdom, using a phrase often associated with jihadists. Makhzoomi denied the charge and returned to the terminal where the Arabic-speaking employee refunded his ticket.
The Berkeley student booked a new flight on Delta Air Lines and arrived in Oakland eight hours after he had planned. Makhzoomi said he does not plan to pursue legal action, but he wants Southwest Airlines to apologize for the ways its employees treated him.
Zahra Biloo, of the Council on American-Islamic Relations, said there have been at least six cases of airlines pulling Muslims off flights so far this year. Southwest Airlines released a statement saying it does not condone or tolerate discrimination of any kind.
Hes a student at Berkeley, where does he get the “refugee” status from? This kid was looking for a reaction and he got it! If I say “bomb” anything close to that on an airplane, I’d assume I’m gonna get some attention and be taken off the plane.
He has to pay for his education and he is smart enough to know that someone will do the dirty work for him. Another stunt for today’s reading.
Southwest Airlines say it was the CONTENT of the conversation, not that he was speaking Arabic, that he was removed. This guy made the mistake of getting on a plane where a passenger and a flight attendant both spoke Arabic.
Can at least one of the people who voted this down, please explain why. Should we allow people who by their actions pose a possible threat to continue on the plane. If so, should we allow the other passengers the choice of deboarding at that point. Should the pilot and flight attendants also be allowed to leave. Or do you hate Southwest Airlines and hope for a crash?
Do you speak Arabic and have a transcript of this student’s conversation? So, you think that he was not a threat or not trying to frighten people so he could get kicked off the plane and sue the airline?
Do you not realize that Southwest Airlines probably flies more Middle Eastern passengers, (connected with the oil industry) than most airlines–all without incident and apparently has flight attendants who speak Arabic. Or do you just want to believe that Southwest is Islamophobic because it has the word South in its name?
More importantly, do you have a transcript? I read the article above, and it did not mention specific language used by the passenger. Therefore, all of the actions you have suggested (passengers and crew leaving) are based on the assumption that this guy said something threatening, without any evidence for it.
It is important to have the evidence before weighing in on either side. You and the poster above have failed to take this crucial step.
Correction. You are the poster above. You have failed this test twice.
Maybe he was talking to that clock-kid, getting advice on how to get his 15 minutes of fame?
This guy knew exactly what he was doing. He’s looking for a payday. | 2019-04-20T00:43:30 | https://calcoastnews.com/2016/04/iraqi-refugee-taken-off-california-flight/ |
Minihane Overseas Investments Limited was set up on Monday the 23rd of July 2007. Their current partial address is Co Cork, and the company status is Normal. The company's current directors have been the director of 7 other Irish companies between them; 2 of which are now closed. Minihane Overseas Investments Limited has 2 shareholders. | 2019-04-19T04:47:26 | https://www.solocheck.ie/Irish-Company/Minihane-Overseas-Investments-Limited-443573 |
Harvard University is hardly a bastion of conservativism, but the Harvard Republican Club, for the last 128 years, has always endorsed the Republican nominee for president. This year, the Harvard Republican Club broke with tradition and said it would not support Donald Trump, the GOP nominee.
The group, which is the oldest college Republicans’ club in the country, said it also wouldn’t endorse Hillary Clinton, the Democratic nominee. | 2019-04-22T12:10:45 | http://fortune.com/2016/08/05/harvard-republican-club-trump/ |
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Click the River Turtle dot to dots to view printable version or color it online (compatible with iPad and Android tablets).
You might also be interested in dot to dots from Reptiles category.
This Dot to dot was posted on Wednesday, April 6, 2016 - 21:33 by painter. | 2019-04-19T19:10:33 | http://www.supercoloring.com/dot-to-dots/river-turtle |
The remains of Monmouth Castle are not huge, due to it being pretty thoroughly slighted after the civil war. However, this castle was at one time an important stronghold in the troublesome border area between Wales & England, and is most famous for its association with King Henry V, who was born there. Today the site is the headquarters of the Royal Monmouthshire Engineers Militia, based at Castle House next to the ruins, which makes Monmouth Castle one of the few British castles still to have a military presence.
Henry V was born in 1387 but is still very much present in Monmouth today. There are numerous references to him and his exploits- Agincourt Square is a lasting tribute to his victory over the French at this famous battle. We had a lovely all-day breakfast at a cafe called Henrys just off the main square, so his memory very much lives on- despite the fact that he actually fought against the Welsh during the revolt of Welsh rebel Owain Glyn Dwr.
Despite the castle being forever linked to Henry, it was actually built very early on after the Norman invasion by William FitzOsbern, a trusted friend of the Conquerer. Controlling the borders was of paramount importance, so the castle was constructed by 1069, just three years after the invasion.
It lasted until the civil war, when the main round tower was demolished. Great Castle House was built on the site of the demolished castle in 1673, and became the home of the Assize Courts until 1725. The remains of the great hall and tower are the main part of the ruins today. They are free to visit, and make a pleasant stroll-around, especially the Gardens of Remembrance at the back of the castle. Part of Great Castle House is used as the regimental museum, which is also interesting to visit.
If you are visiting Monmouth, then the other attraction in the town is the fortified medieval bridge, the only one of its kind to survive in Britain. It is a ten minute stroll from the castle, and is certainly worth a look. The surviving gate tower was built to defend the river Monnow. However, as the river is quite shallow it could easily be crossed just by wading- as the dog in our final photo shows- so it was probably more use in generating road tolls than actually protecting the town. As the bridge is often used as a symbol for the town today, it seems it is still earning its keep as a tourist attraction for Monmouth. | 2019-04-24T06:55:29 | http://www.castles4kids.info/index.php/monmouth-castle |
Bread And Pastries In Ras Al Khaimah images, videos and news can be Yalla at inside.ae a new search engine that allows you to organize search by bringing the results that are important to you to the top with a single click.
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The Broke and the Bookish : Kelly reviews "The White Princess" by Philippa Gregory + giveaway!
Kelly reviews "The White Princess" by Philippa Gregory + giveaway!
The White Princess is fifth in The Cousin's War series revolving around the Plantagenet family. I read this series in the completely wrong order: book one, two, five, four, and then three. This would usually drive me nuts but I'm pretty familiar with this time period so it all still made sense. The latest release revolves around Elizabeth of York, King Edward IV's oldest daughter. Historically, we know her most famously for being the mother of Henry VIII, yet there aren't really many books that center around her, so this was exciting to pick up. Philippa and I have had our struggles in the past, but I still keep coming back for more.
In the series, we've left off right after Richard III is killed and Henry VII takes the throne. Elizabeth knows she comes as part of the package in Henry's ruling of England, but of course she's not eager to marry the man who stole her family's throne and killed her uncle. Henry certainly isn't a pleasant man in the beginning (aka he's HORRIBLE; what an awful portrayal of a pretty decent guy in reality), especially in his treatment of Elizabeth, but they eventually grow into somewhat happy pair. With a childhood spent in hiding, most of her family members meeting tragic ends, an unwanted husband, a rocky time as Queen, and the loss of many of her children, Elizabeth had quite an interesting life, but we don't see much of it in this book. She's pretty clueless throughout the entire thing (she says "I don't know" at least 400 times and most of her dialogue is her simply repeating what was just said previously) and at times I felt her character was underdeveloped and that she was simply observing things around her rather than participating in them (boooringgg).
Now I think Philippa Gregory writes wonderful fiction full of action (okay, not so much in this one), intense characters, and vivid scenery and life, but I don't like how she pushes many of her speculations as historical fact and her tendencies to make things over-dramatic simply for the sake of a good book rather than historical accuracy (as if this period of time wasn't dramatic enough). For instance, there's a BIG plot in The White Princess that Elizabeth was her uncle Richard III's lover (NO NO NO NO). There is only one tiny shred of historical evidence pointing to this and it's awkward to push this so heavily in a book (it's also a big point in the television show based on the series as well). Gregory's focus on Elizabeth and her female ancestors being descendants of a water goddess and consequentially sorceresses, if that's the right word, themselves is cool to an extent but mostly made me want to face-palm the entire time. The constant 'prophecies' Elizabeth kept relaying felt a little over the top - ("our family line will end with a red-headed girl," yeah yeah yeah). Still, I've enjoyed this series so far for what it is - "historical entertainment" (heavily twisted and imagined fiction as well). This was a good addition, even with a little debate and eyebrow-raising moments along the way - just don't take anything too seriously.
Giveaway! I have a beautiful hardcover copy of The White Princess to give away to one of you! US residents only - simply leave a comment below by August 16th to be entered.
I bought this book at the airport without knowing it was a part of a series. Would I be able to read this book without reading book 1? Probably not, huh? I too have a hot and cold love affair with Ms. Gregory but she writes some pretty detailed historical fiction.
Sorry you didn't like this as much, though. Maybe next time?
I think you could read this one on it's own, but reading Book 1 and 2 would be more helpful, you'd get much more out of the story!
I am anxious for her next book in the series though, she's picked a very interesting character to focus on.
I keep seeing this series everywhere and it looks awesome!
Interesting that they're not historically accurate. She strikes me as the type of author who loves the time period so much that she'd work really hard to make them accurate.
You'd think so, huh? She often stresses the point that she's a "historian."
I just LOVE Philippa Gregory's books! Her novel The Other Boleyn Girl was what really got me hooked on historical fiction, which I read the majority of the time. I always take the events in historical fiction novels at face value until I can read through the author's notes most of them include to see what is fact and what is fiction. I am really excited to read this novel, so thank you SO MUCH for a chance to win a copy!
Same here, The Other Boleyn Girl is what peaked my interest in historical fiction! I'll always have a soft spot for that book, no matter how inaccurate I now know it to be.
Gregory's Author's Note at the end of this book was quite interesting...she wrote how she hoped she portrayed each character with respect....yet she completely tore apart Henry VII in the book. Weird!
Thanks for the giveaway! I've got all the Cousins' Wars books on hold at the library but I haven't read ay of them yet.
I already have my DVR set to tape the show on Starz, but I want to read the books first. I'm still on hold for the first book. Thank you for posting this giveaway.
I have my DVR set to tape The White Princess on Starz this weekend. I have been on hold for the first book for quite awhile. Thank you for the review and giveaway!
I don't know where I've been but I've just discovered your blog, and I love it. And I love Philippa Gregory's books. If you have a chance, visit me at Found Between the Covers, my fairly new book blog, or at Healing by Writing where I do my writerly things.
Love the historical fiction reviews! I've just started reading HF this year so I love hearing about all the recommendations. Thanks!
I am having trouble with my computer so this is my third try!
Phillipa Gregory knows how to make the history come alive. Thank you for the review that poibted out what is purely fiction. I will remember that when I read this book. Thank you so much for the chance to read this book.
I really enjoyed Phillippa's Tudor books but I've been reluctant to start this series. Lately, though, I've been thinking of starting up with it. Thanks!
I enjoy your blog and recommendations!
Thanks for the review! I love historical fiction and have read other books by Philippa Gregory including The Constant Princess and The Queen's fool.
OMG I would love to win a copy of this book! I just started Lady of the Rivers so I only have one more to go....loving the series so far!
I'd like to try this one. thanks for the giveaway.
Yeah I'm unsure of how I feel about this series. While ordinarily I'm all about fantasy and magic etc. I really just want...historical fiction. Just that.
Historical fiction and fantasy are my two favorite genres, but getting them to mesh successfully can be difficult!
I always check on series order in Goodreads. Reading out of sequence would drive me nuts. This sounds like a fabulous read!
I really like this series. I had just read Alison Weir's The Wars of the Roses before I started this series so all the back and forth between the time periods didn't confuse me as much. Thanks for the giveaway!
I've read The Prince's in the Tower by her, where she firmly suggests that Richard III killed the boys. It'll be interesting to read The War of the Roses with that in mind!
I checked out the first episode of the adaptation on Starz and it seems like it will be a really interesting series!
i've been eyeing this book since i learned of it!!
I haven't read any of the book in this series, but this one sounds so good. I would love to read it. Please enter me. Thanks!
I just watched the first Starz adaptation and would love to delve deeper.
I've been keeping up with the series as it's aired in the UK and it's pretty smutty and frivolous, but it's got some great historical details /scenery as well as actors!
Despite the fact that you did not enjoy this one I'd really love to give it a chance. I do enjoy Philippa's writing overall!
I want to read her books so bad!
I've read "The Other Boleyn Girl", "The Boleyn Inheritance", and I am currently reading "The White Queen" by Ph. Gregory. I find her writing style very pleasant and I'm well-aware that 90% of what she writes is fiction, but she has a way of narrating things that makes you feel as if what you read has truly happened. The 'all-women-in-this-family-are-sorceresses'-thing kind of bugs me, too, because at certain points it pushes things too far (as in propelling characters into new situations solely based on magic). However, Gregory has become one of my favorite authors.
I find I can quite enjoy her books if I somehow overlook her tendencies for inaccuracy. The Boleyn Inheritance is probably my favorite book by her!
It actually makes sense to read Lady of the Rivers first as it would come first time-wise! It was a bit odd reading a book about Elizabeth Woodville first, then two books later reading about her mother, Jacquetta, as a young adult.
I loved her Tudor novels and am not enjoying the Cousins Wars books nearly as much but I'd like to give this one a try. | 2019-04-22T12:44:47 | http://www.brokeandbookish.com/2013/08/kelly-reviews-white-princess-by.html |
Patty Jenkins revealed the upcoming sequel is titled Wonder Woman 1984 and will see the return of Steve Trevor.
Contrary to earlier reports that stated that the Wonder Woman sequel will be filmed in the UK, it will be shot in the US around the area of Northern Virginia/District of Columbia, reports claim.
In her recent appearance on Good Morning America, Gal Gadot confirmed that Brett Ratner will not be involved in the sequel of Wonder Woman.
Gal Gadot has reportedly refused to sign Wonder Woman 2, until co-producer and sexual harassment accused Brett Ratner is fully removed from the franchise.
Wonder Woman is the highest grossing Hollywood film to be directed by a woman.
Wonder Woman 2 is set to storm theaters on 13 December, 2019. Warner Bros. announced the date late Tuesday. Gal Gadot will reprise her role as Wonder Woman.
Original Wonder Woman Lynda Carter to appear in sequel of Gal Gadot's film?
Lynda Carter, who played Wonder Woman in the 1970s TV show, revealed that she was also in talks to appear in the first part but their dates did not match.
Wonder Woman 2 is likely to star Chris Pine too, who played Steve Trevor in the first part that released last month.
Wonder Woman has earned over $573 million worldwide to date. | 2019-04-26T13:56:54 | https://www.firstpost.com/tag/wonder-woman-sequel |
Generally, LASIK is performed on patients who are nearsighted (myopic), farsighted (hyperopic) and/or have astigmatism. Additionally, an ideal candidate has good overall eye health and has had a stable vision prescription for the past couple years. Age is taken into consideration as well. It’s important that your prescription has stopped significantly changing (typically 19 – 25 years of age) and that you haven’t yet experienced any cataract formation (cataracts are common in the 60’s).
Minnesota Eye Consultants offers complimentary LASIK Screenings for new patients that have not undergone previous eye surgery. Only through a thorough examination is your doctor able to determine what vision correction option is right for you. If LASIK is not the best option, your surgeon will work with you to determine what vision correction method does make sense. LASIK is only one of the many options you have at Minnesota Eye Consultants.
Contact us, or use the form below, to see if you qualify for a Free Screening appointment and to set up your one-on-one consultation with a highly trained and experienced Minnesota Eye Consultants surgeon.
You have finally decided to ditch your contacts and glasses for good and upgrade your vision with LASIK. You likely have lots of questions – What occurs during the evaluation? What is the procedure like? What should I expect following surgery? We’re here to help educate you on all of this information, and ensure that you’re prepared for your LASIK consultation and surgery at Minnesota Eye Consultants.
Take advantage of the opportunity to speak with a surgeon about the entire LASIK experience, including any concerns or hesitations that you might have. You can get answers to your questions directly from the doctors that perform the procedures.
Contact Lenses – Since contacts temporarily alter the shape of your cornea, you’ll be asked to remove your Soft Contact Lenses two weeks prior to your appointment. If you wear Hard or Toric Contacts, it’s important to remove them three weeks (or more) prior to the testing to make sure your measurements are accurate.
Pregnancy – For a number of reasons (such as changes in metabolism, hormones and blood circulation), vision can shift during pregnancy and while nursing. As a result, we recommend scheduling your evaluation at least three months after you’ve finished nursing. This allows your eyes enough time to stabilize following pregnancy.
The appointment begins with corneal testing to assess the thickness and shape of the cornea. The WaveScan system is used to capture the unique shape of your eye, considered to many as “the fingerprint of the eye”. The technician will also measure your eye pressure and a Topography will create a 3D mapping of the cornea.
A refraction (the portion of the exam that typically determines the glasses prescription) is then performed by a technician. “Which is better, one or two?” Dilation drops are administered and it typically takes 15-20 minutes for your pupils to enlarge.
Your LASIK surgeon will examine your eyes using a high-intensity light on a slit-lamp microscope. This offers a glimpse inside the eye where your physician can search for various eye diseases and disorders, and rule out any possible red flags.
Following the testing, your doctor will want to learn more about your hobbies, lifestyle and visual goals. The surgeon will discuss his or her surgical recommendations with you. Visual and recovery expectations following surgery are also a large part of this discussion.
If it’s decided you are an ideal LASIK candidate (congratulations!), you will have the opportunity to meet with one of our specialty trained Appointment Coordinators. They will discuss pricing, answer any remaining questions you may have, and help to find a surgical date that fits your schedule.
We completely understand that LASIK can be scary and overwhelming. Hopefully the following details outlining every step of surgery will help put your mind at ease. If you’ve had your evaluation and would like to schedule your procedure, you can reach our Surgery Scheduling Department at (952) 567-6101.
Contacts – You will again be asked to discontinue your contacts prior to the surgery. If you have questions about this, please reach out to your Appointment Coordinator for clarification.
Driver – Please arrange to have a driver for the day of your procedure. You will be offered Valium prior to surgery, and may experience light sensitivity and some watering eye(s) as you leave our office.
Prescriptions – You will likely have some medications sent to your pharmacy prior to surgery. Please pick these up ahead of time and bring them with to your procedure.
Depending on the evaluation location and the results of the tests captured at the initial appointment, additional or repeat testing may be required prior to the procedure. A surgical technician and the surgeon will review your chart to ensure all necessary testing is completed.
You will meet with a Pre-op Coordinator to discuss discharge instructions, eye drops to be used following the surgery, and offered a valium (to help relax, if you wish). A technician will bring you into the Laser Suite and administer numbing drops and cleanse the surgical area. Both the supporting surgical staff and your surgeon will walk you through each step of the procedure.
Your surgeon will place an eyelid speculum to separate your eyelids and ask you to recline on what appears to be a dentist’s chair. The Intralase laser is used to administer pulses of laser light to create the corneal flap. This is the “Intralase” or “iLASIK” method of creating the flap versus the Microkeratome (blade) option.
You will be swiveled from the Intralase machine to the VISX Excimer Laser where the flap is carefully lifted by your physician. Using data that has been collected, the surgeon will use the laser to safely and effectively reshape the cornea. You’ll hear a series of “ticking” noises as the laser vision correction is being performed.
Once the treatment is complete, your surgeon will replace the flap and repeat the same steps with the other eye. Your first set of eye drops are administered immediately, and a clear plastic shield will be placed over each eye for protection. You’ll be given sunglasses as you may be light sensitive, and will be instructed to go home and rest for the remainder of the day. You will need to be seen by your primary eye doctor, or by a physician at Minnesota Eye Consultants, the following day for a checkup. | 2019-04-24T10:04:00 | https://www.mneye.com/lasik-center-minneapolis/lasik-evaluation-surgery/ |
This entry was posted in Bollywood, Entertainment, Society and tagged Aamir Khan, Amitabh Bacchan, Inspiration, Satyamev Jayate, Shahrukh Khan, Society by kushsrivastava. Bookmark the permalink.
His inclination towards delivering message to the society can be seen in many of his movies as well. He has, in fact, carved a place for himself in film industry, which is few notches above his contemporaries. I do hope that others in public life would take a cue from this and will be known for better things than picking up brawl/driving vehicles over innocents. | 2019-04-21T11:07:20 | https://kushsrivastava.com/2012/07/07/papa-kehte-hain/ |
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You can catch Football free live streaming of your favorite Itf tour teams and athletes, as they play their most important matches. All you need is your computer, smartphone, or any other mobile device to be constantly updated of the action as they unfold in real time. The good news for you is, our Football live stream is 100% free. There’s no need for you to sign-up or pay any fees. Now, you can catch your favorit Georgia Football Itf tour events wherever you are on the planet. | 2019-04-24T21:55:33 | https://www.streamsports.ws/leagues/itf-tour |
These kitchen fitter's packs include a choice of four or five-piece sets with straight flute cutters and worktop cutters or biscuit jointers, in varying dimensions, for a range of kitchen installation and finishing tasks. All the cutter and joiner tool sets are ideal for making easy work of cabinet construction and woodworking joints, or for neatly trimming worktops for a precise fit. The products on offer in this range are top quality; please refer to the additional information for specifications including diameter and length. | 2019-04-23T05:59:12 | https://www.cnspowertools.co.uk/trend-routing-products/trade-router-cutters/kitchen-fitters-cutter-packs |
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