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DAVAO CITY (MindaNews / 10 June) – The City Government of Davao will keep the policy on the mandatory wearing of face masks because it provides a “first layer of protection” against the highly infectious coronavirus disease (COVID-19), a health official said.
Dr. Michelle Schlosser, spokesperson for the Davao City COVID-19 Task Force, said during an interview over Davao City Disaster Radio (DCDR 87.5) on Friday that the possibility of further relaxing the policies on minimum public health standards (MPHS) is remote as local authorities are not even contemplating on removing the requirement of wearing of face masks.
She said most of the health protocols here have already been eased. She added that removing the mandatory wearing of face masks in closed or open spaces will put the individuals at greater risk of contracting the infection.
“The COVID-19 Task Force is not yet discussing it. At the moment, we do not see it necessary to lift the restriction,” she said.
Schlosser said this after she was asked if it is possible for this city to lift the mandatory wearing of face masks after Cebu Governor Gwendolyn Garcia ordered the removal of the restriction in open spaces and outdoor settings in her province.
Schlosser said the local government would follow recommendations of the Department of Health and World Health Organization about the wearing of face masks, which is effective in the prevention of COVID-19.
“This is the only way to protect us from transmission of the disease. The transmission happens through respiratory droplets by sneezing or coughing. We may inhale it from infected individuals and the way to protect us from that is by wearing face masks,” she added.
Schlosser said it is important for the public to continue observing the health protocols because to effectively combat the infection is a “matter of discipline.”
She said authorities believed another surge may just be a matter of time if people don’t follow the protocols.
Aside from protocols, Schlosser said the vaccination also offers protection from transmission and severity of the disease.
“I know it’s very uncomfortable to wear your face masks for the whole day but that’s the only way to protect ourselves and our loved ones, especially if you go to places where you don’t know the people you interact with and where they come from… Again, we cannot see our enemy,” she said. (Antonio L. Colina IV / MindaNews) | https://www.mindanews.com/top-stories/2022/06/davao-city-not-lifting-mandatory-wearing-of-face-masks/ | 2022-06-10T11:17:14Z | https://www.mindanews.com/top-stories/2022/06/davao-city-not-lifting-mandatory-wearing-of-face-masks/ | true | 1 |
Ukrainian Eurovision Winners Auction Off Trophy to Support Their Country Amid Russian Invasion
Earlier this month the Ukrainian group Kalush Orchestra took home the win at the 2022 Eurovision Song Contest. Now they are using the opportunity to help support their home country during the ongoing Russian invasion.
According to Reuters, the group held an auction to sell the crystal trophy they picked up for their song "Stefania." Proceeds from the sale were donated to the armed forces to purchase several drones.
The auction was held on Facebook and raised approximately $900,000.
“You guys are amazing," the group enthused on Facebook, according to The Hollywood Reporter. "We appreciate each and every one of you who donated to this auction, and a special thanks to the team (of cryptocurrency exchange) Whitebit who purchased the trophy for $900,000 and are now the rightful owners of our trophy.”
Kalush Orchestra secured the win earlier this month. CNN notes they took the stage to a warm welcome from fans. This marked the third time Ukraine took home the win in the contest, which has been around since 1956.
Ukrainian President Volodymyr Zelenskyy celebrated the news with a proud post on Instagram.
"Our courage impresses the world, our music conquers Europe," he wrote, according to a translation provided by Google. "Next year Ukraine will host Eurovision!"
The president proposed hosting the event in Mariupol and said that he hopes it will be "free, peaceful, rebuilt" by the time the song contest starts up again in 2023.
"I am sure that our victorious chord in the battle with the enemy is not far off," Zelenskyy added.
Check out his post below:
The band members of Kalush Orchestra have used their global fame to help support Ukraine. The BBC reports they also appeared at a charity concert in Berlin. While the auction benefits the military, funds from the concert will help provide medical care. | https://wibx950.com/ukrainian-eurovision-winners-auction-off-trophy/ | 2022-06-10T11:23:06Z | https://wibx950.com/ukrainian-eurovision-winners-auction-off-trophy/ | true | 4 |
Linnea Sorensen falls into a funk whenever her girlfriend of four years leaves for her six-month stints with the Marines, and the high school junior has trouble concentrating on her classwork.
"I'm somebody who struggles with my mental health quite a bit," said the 17-year-old, who attends school in Schaumburg, Ill., a suburb of about 77,000 people northwest of Chicago. "When you're in school and not fully mentally there, it's like you're not really grasping anything anyway."
Now Illinois is giving Sorensen and students like her a new option for dealing with mental health lows. The state allows K-12 students in public schools to have five excused absences per school year for mental health reasons, another example of the growing acknowledgment among lawmakers that emotional and physical health are intertwined. The new policy, which went into effect at the beginning of 2022, passed both chambers of the state legislature unanimously.
But such novel policies are, in many ways, a half-step toward addressing the crisis of teenage mental health that has been highlighted and exacerbated by the educational interruptions caused by the pandemic. Many parts of the country are woefully short of therapists who can work with students to address mental health problems.
Seventy percent of schools that responded to a federal survey in April said more students had sought mental health services since the pandemic started. The National Center for Education Statistics' polling also showed that only 56% of schools said they effectively provide mental health services to all students in need and just 41% reported hiring new staff members to help address students' mental health needs.
Nearly half the nation lives in a designated mental health worker shortage area, according to government data, and an estimated 7,550 new professionals are needed to fill that void nationwide. Even in places where mental health professionals are more plentiful, they often do not accept public insurance, making them inaccessible to many kids.
In other states where lawmakers have implemented policies that allow students to take mental health days — including Arizona, California, Colorado, Connecticut, Maine, Nevada, Oregon, Utah and Virginia — a lack of services for young people remains a concern.
Schools in Colorado, Indiana, Maryland, Utah and Washington, D.C., have tried to narrow the gap through less costly solutions, such as in-class meditation, mindfulness rooms and social-emotional learning. The latter became a curriculum target of conservative lawmakers in recent months.
Greatest mental health needs
In a 2020 Mental Health America survey of young people's greatest mental health needs, the top responses from 14- to 18-year-olds were access to mental health professionals and mental health absences or breaks as part of school or work.
"The more we can shift to a prevention mindset and integrate mental health promotion into schools from a young age, I see that as very key to helping reduce the needs for treatment that we see in young people," said Tamar Mendelson, director of the Center for Adolescent Health at the Johns Hopkins Bloomberg School of Public Health.
Education officials and mental health experts in Illinois say the mental health day policy is a good start toward tamping down a youth mental health crisis that had been growing during an era of school shootings and cyberbullying and then exploded during the pandemic. The move is another indication that schools are increasingly being relied upon to meet students' social needs, from feeding, clothing and vaccinating them to spotting abuse and neglect.
"I've been a teacher for 19 years, and this is as bad as I've seen it," Ben Lobo said of the mental health of his students at Schaumburg High School.
Susan Resko, president and CEO of the Josselyn Center, a community mental health center north of Chicago, said the pandemic was "like putting a match to fuel."
Before March 2020, the nonprofit received about 50 new clients a month, Resko said. That number is now 250, and two-thirds are children or young adults. The organization hired 70 therapists in the past year and has received an influx of requests for mental health counseling services from local schools.
Some critics of the new Illinois law note that it excludes families that don't have ready access to child care. And a lack of data from some schools means officials don't know whether the policy is being used.
The Illinois State Board of Education does not require schools to report how many students are taking mental health absences. KHN contacted the 10 largest school districts in Illinois seeking that data. Six didn't respond (the districts based in Elgin, Aurora, Algonquin, Oswego, Romeoville and Schaumburg), and three said they either aren't tracking that number (Chicago) or couldn't release it (Rockford and Naperville).
School officials in Plainfield, Ill. — a town about 35 miles southwest of Chicago whose district has an enrollment of more than 25,000 — said 3,703 students took a combined 6,237 mental health days from early January through the end of the school year. That means nearly 15% of the student body used an average of 1.7 days per student. Officials also noted that 123 of those days were used on the last day of school before summer break.
The community had been seeking to provide more services to students even before the pandemic hit. In 2019, Plainfield Community Consolidated School District 202 added 20 social workers after data showed that overnight hospitalizations of any kind among students had more than doubled in the previous five years. That type of staff expansion just "doesn't happen in education," said Tim Albores, the district's director of student services.
No money, no staff
Under the state's new policy, after students have a second mental health-related absence, district officials are required to refer them to the "appropriate school support personnel." But many schools can't afford the types of services Plainfield is offering, education officials say, and in rural areas they sometimes have trouble finding people to fill those jobs.
Chicago isn't scheduled to have a social worker in each of its more than 600 schools until 2024. School social workers there often devote most of their time to students who receive special education services dictated by an individualized education program, or IEP.
"My door gets knocked on all day long. And I have to choose — am I going to reschedule my IEP services, or am I going to help a student who's experiencing a crisis like right now?" said Mary Difino, a social worker at Brian Piccolo Elementary Specialty School on Chicago's West Side. "The neighborhood I work in, there's a lot of trauma, there's a lot of community violence, there's a lot of death and hardship."
Fourteen-year-old Heaven Draper, an eighth-grader at Brian Piccolo, said she had used two mental health days: one to take a break from a chaotic classroom environment — she said she sometimes feels more like a teacher than a student — and another to de-stress from the pressures of applying and testing for high schools in the city. "This is our first year back in person from quarantine," she said. "It's gotten overwhelming at times."
Her classmate Ariyonnah Brown, 14, said she took a day to help defuse a situation with another student. She said she'd like to see more awareness of mental health among adults, especially in communities of color like hers.
"Parents need to be educated," said Sheila Blanco, 57, a food distribution purchaser from Chicago whose 14-year-old daughter, Carli, died by suicide in 2017. "So many parents, they don't know what resources are, and even if there are resources, to help out the child or help them to help the child."
Anna Sanderson, a Schaumburg High School junior, said she believes the policy is a good idea, just not for her. "If I miss a day because I'm overwhelmed or not feeling well mentally, I feel like when I go back, I'll only be worse," the 17-year-old said. "I'll have to make up assignments and tests and be behind in my classes."
But she said she hopes it's a sign of greater support for students' mental health. She said schools sometimes fail to acknowledge student suicides or to provide counseling that goes much beyond education.
"I feel like we get dismissed a lot of the time," she said.
If you or someone you know may be considering suicide, contact the National Suicide Prevention Lifeline at 1-800-273-8255 (En Español: 1-888-628-9454; Deaf and Hard of Hearing: 1-800-799-4889) or the Crisis Text Line by texting HOME to 741741.
KHN (Kaiser Health News) is a national newsroom that produces in-depth journalism about health issues. It's an editorially independent operating program of Kaiser Family Foundation.
Copyright 2022 Kaiser Health News. To see more, visit Kaiser Health News. | https://www.kdlg.org/as-heard-on-npr/as-heard-on-npr/2022-06-10/more-states-are-allowing-students-to-take-mental-health-days-off | 2022-06-10T11:23:10Z | https://www.kdlg.org/as-heard-on-npr/as-heard-on-npr/2022-06-10/more-states-are-allowing-students-to-take-mental-health-days-off | false | 33 |
Grab Your Doughnuts, Classic Anime ‘Trigun’ Is Rumored to Be Getting a New Series
Love & Peace!
When it comes to releasing a new adaptation to a franchise, anime has had a pretty stellar track record. Fullmetal Alchemist: Brotherhood, Hunter x Hunter, Fruits Basket, the thought of a reboot to an anime series is usually met with positive reception for a reason. The quality of animation tends to be better, and if the work is based on the manga, we usually get to see parts of the story that didn’t make it into the original.
So when a Twitter post started making the rounds that claimed that we’d be getting a new adaptation for Trigun, everyone got excited – including Vash’s original dub voice actor, Johnny Yong Bosch.
Love & Peace!
While there’s nothing to confirm whether or not this is true, if it does end up being legit, this would be a pretty amazing reboot for a classic anime series. Based on the manga by Yasuhiro Nightow, the story focuses on the 60 billion double dollar man, Vash the Stampede, and takes place in the 32nd Century. Despite his dangerous reputation, Vash is a kindhearted, lovable, doughnut-eating good boy who doesn’t want to fight anyone. However, when you accidentally destroy a city with your supernatural powers, folks tend to think the worst of you – not that Vash actually remembers the destruction he caused, or much of anything from his past, really (damn that amnesia).
To be honest, whenever there’s damage done, it’s not actually Vash’s fault. The ones going after him are usually responsible for the chaos. Vash is genuinely a good person who wants to do what’s best for humanity, but anime can’t make it that easy on its protagonist.
I was introduced to Trigun back when it aired on Toonami. Originally released in 1998 in Japan (with the manga starting in 1995), the series premiered here in the U.S. in 2003. It was stylish and full of action, with a protagonist that you came to care for pretty quickly, and it was one of my earliest examples of “if your anime protag smiles a lot, it means they’ve suffered a great deal in their life.” It also has one of my top 10 saddest anime deaths along with one of my all-time favorite AMV crossovers, “Tainted Doughnuts” by E-Ko, where Spike (Cowboy Bebop) pursues Vash to try and collect that bounty.
Why this is a big deal
Assuming this rumor is legit, a Trigun reboot would be fantastic to see. That’s not just because I’m a fan of the original and long for the return of that slick ass coat Vash wears, but the anime is, technically, predominantly filler! It’s hard to tell because the episodes are so good and everything feels like it makes sense the way it’s presented, but according to the website Anime Filler List, out of the anime’s 26 episodes, 17 are filler!
I was, legitimately, today years old when I found that out. I thought for sure this was the story as it’s told in the manga. A new adaptation would give us the chance to see more of the manga’s story animated. Like. What did we miss out on back in the early 2000s?
(Image: Satoshi Nishimura/Madhouse)
—The Mary Sue has a strict comment policy that forbids, but is not limited to, personal insults toward anyone, hate speech, and trolling.—
Have a tip we should know? [email protected] | https://www.themarysue.com/trigun-anime-rumor/ | 2022-06-10T11:24:19Z | https://www.themarysue.com/trigun-anime-rumor/ | true | 1 |
ESA's Mars Express captures a 30 km-wide crater that resembles human eyeball
The European Space Agency's Mars Express mission has beamed back a picture of a 30 km-wide unnamed crater on the Red Planet. Captured on 25 April 2022, this image shows part of Aonia Terra, an upland region in the southern highlands of Mars known for its impressive craters.
Sharing the image, the agency said, "The 30 km-wide unnamed crater at the centre of the image is nestled within a landscape of winding channels. Conjuring images of veins running through a human eyeball, these channels are likely to have carried liquid water across the surface of Mars around 3.5–4 billion years ago."
The image captured by ESA's Mars Express reveals many different colours in the surface around the crater, suggesting that this region is made up of a variety of materials. Inside the crater, there are several buttes and cone-shaped hills.
Our @esascience Mars Express mission captured this 30 km-wide crater nestled between winding channels on #Mars - resembling veins running through a human eyeball 👁 The channels likely carried liquid water around 3.5–4 billion years ago!👉https://t.co/sKbNxVAQxx #ExploreFarther pic.twitter.com/SBfBeOB8OO
— ESA (@esa) June 10, 2022
Mars Express has been exploring the Martian atmosphere and surface from polar orbit since its arrival at the Red Planet in 2003. The mission's main objective is to search for sub-surface water, which could exist in the form of underground rivers, pools, aquifers or permafrost.
The instruments onboard the Mars Express including the High Resolution Stereo Camera (HRSC), responsible for these new images, has revealed much about Mars' diverse surface features.
Initially, the mission also carried a small lander, called Beagle 2, but it was lost on arrival in December 2003.
- READ MORE ON:
- Mars Express crater picture
- ESA Mars Express
- ESA Mars mission | https://www.devdiscourse.com/article/science-environment/2068278-esas-mars-express-captures-a-30-km-wide-crater-that-resembles-human-eyeball | 2022-06-10T11:25:09Z | https://www.devdiscourse.com/article/science-environment/2068278-esas-mars-express-captures-a-30-km-wide-crater-that-resembles-human-eyeball | true | 1 |
MELBOURNE, Australia and INDIANAPOLIS, June 10, 2022 /PRNewswire/ -- Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) and RefleXion Medical, Inc. (Hayward, California, U.S.) (RefleXion) today announced the signing of a co-development and commercialisation agreement, to expand the use of Telix's prostate cancer imaging agent, Illuccix® (kit for preparation of gallium (68Ga) gozetotide) with the RefleXion® biology-guided radiotherapy (BgRT)* platform to guide external-beam radiotherapy in real-time.
BgRT is the first and only cancer treatment designed to integrate PET technology as part of external-beam radiotherapy delivery. It uses PET tracers as biological guides to signal the location of cancer and guide the delivery of radiotherapy to tumors in real-time. BgRT has the potential to offer significant advantages over conventional radiotherapy as it may one day enable treatment of multiple tumors per session for metastatic disease, increase the conformality of radiotherapy delivery, and reduce toxicity to healthy tissue. This approach may facilitate treatment of later stage cancers than is currently practical for hospitals or tolerable by patients.
Under the agreement, which builds on an existing strategic collaboration[1] between the companies, Telix and RefleXion will conduct and co-fund a BgRT clinical program using Illuccix as a biological guide, seek regulatory approval and jointly pursue commercialization, initially in the United States. The parties will share in any upside generated if successfully commercialized. The clinical program is expected to commence in 2023. RefleXion is exclusively partnering with Telix for 68Ga PSMA-PET imaging agents for use with BgRT. The agreement also includes the potential to expand the exclusive relationship beyond the U.S., in countries where both Illuccix and BgRT are intending to be commercialised.
If approved, Illuccix for BgRT could potentially open a broad new market opportunity for Illuccix as a therapy guidance agent. More than 60,000 men undergo external-beam radiotherapy for prostate cancer every year in the U.S. alone[2]. Illuccix for BgRT would require up to five doses per patient (one for each session of external-beam radiotherapy), potentially expanding the volume of Illuccix used in the U.S. significantly. The scheduling flexibility of Gallium-based compounds such as Illuccix may provide additional advantages for patients and caregivers using BgRT technology.
Dr. Christian Behrenbruch, Group CEO of Telix Pharmaceuticals said, "Following a successful evaluation period, we are pleased to expand our relationship with RefleXion and move ahead with a clinical program with the objective of regulatory approval of Illuccix for BgRT. This partnership demonstrates the potential for Illuccix and other molecularly-targeted imaging agents in our pipeline to be used as a tool to both detect the presence of metastatic disease and guide treatment using innovative complementary technologies such as BgRT."
Dr. Thorsten Melcher, Chief Business Officer at RefleXion added, "With PSMA-PET quickly being established as a standard of care in prostate cancer imaging, the clinical program aims to determine whether Telix's gallium-based tracer can provide a complete and robust signal to guide BgRT to treat all stages of prostate cancer, eventually including metastatic disease. Illuccix offers great accessibility and scheduling flexibility, factors which we believe will be well-suited to the treatment regimen with our BgRT system."
Reflexion has received marketing clearance from the United States Food and Drug Administration (FDA) for its X1 machine that combines high quality computed tomography (CT) imaging with stereotactic body radiotherapy (SBRT), stereotactic radiosurgery (SRS) and intensity modulated radiotherapy (IMRT).
About RefleXion Medical
RefleXion is a privately-held company developing the first biology-guided radiotherapy system, a significant change in strategy from single tumor therapy to the ability to one day treat multiple tumors in the same treatment session in cancers that have metastasized. Currently, the RefleXion X1 machine is cleared for the delivery of stereotactic body radiotherapy (SBRT), stereotactic radiosurgery (SRS) and intensity modulated radiotherapy (IMRT). The company is also developing BgRT, which incorporates positron-emission tomography (PET) imaging data to enable tumors to continuously signal their location. The BgRT technology will synchronize these data with the linear accelerator to direct radiotherapy to tumors with sub-second latency. For more information, visit www.reflexion.com and follow RefleXion on Twitter (@reflexionmed) and LinkedIn.
*The RefleXion® X1 is cleared for SBRT/SRS/IMRT. BgRT is pending regulatory review and is not commercially available.
About Telix Pharmaceuticals Limited
Telix is a biopharmaceutical company focused on the development and commercialisation of diagnostic and therapeutic products using Molecularly Targeted Radiation (MTR). Telix is headquartered in Melbourne, Australia with international operations in Belgium, Japan, Switzerland, and the United States. Telix is developing a portfolio of clinical-stage products that address significant unmet medical need in oncology and rare diseases. Telix is listed on the Australian Securities Exchange (ASX: TLX). For more information visit www.telixpharma.com and follow Telix on Twitter (@TelixPharma) and LinkedIn.
About Illuccix® (kit for the preparation of gallium Ga 68 gozetotide injection)
Telix's lead product, Illuccix® (kit for the preparation of gallium Ga 68 gozetotide injection), also known as 68Ga PSMA-11 injection, has been approved by the U.S. Food and Drug Administration (FDA),[7] and by the Australian Therapeutic Goods Administration (TGA).[8] Telix is also progressing marketing authorisation applications for this investigational candidate in Europe[9] and Canada.[10] Illuccix is currently being investigated in combination with BgRT treatment.
INDICATIONS AND USAGE
Illuccix®, after radiolabeling with Ga 68, is a radioactive diagnostic agent indicated for positron emission tomography (PET) of prostate-specific membrane antigen (PSMA) positive lesions in men with prostate cancer:
- with suspected metastasis who are candidates for initial definitive therapy
- with suspected recurrence based on elevated serum prostate-specific antigen (PSA) level
IMPORTANT SAFETY INFORMATION
WARNINGS AND PRECAUTIONS
Risk for Misdiagnosis
Image interpretation errors can occur with gallium Ga 68 gozetotide PET. A negative image does not rule out the presence of prostate cancer and a positive image does not confirm the presence of prostate cancer. The performance of gallium Ga 68 gozetotide for imaging of biochemically recurrent prostate cancer seems to be affected by serum PSA levels and by site of disease. The performance of gallium Ga 68 gozetotide for imaging of metastatic pelvic lymph nodes prior to initial definitive therapy seems to be affected by Gleason score. Gallium Ga 68 gozetotide uptake is not specific for prostate cancer and may occur with other types of cancer as well as non-malignant processes such as Paget's disease, fibrous dysplasia, and osteophytosis. Clinical correlation, which may include histopathological evaluation of the suspected prostate cancer site, is recommended.
Radiation Risks
Gallium Ga 68 gozetotide contributes to a patient's overall long-term cumulative radiation exposure. Long-term cumulative radiation exposure is associated with an increased risk for cancer. Ensure safe handling to minimize radiation exposure to the patient and health care workers. Advise patients to hydrate before and after administration and to void frequently after administration.
ADVERSE REACTIONS
The safety of gallium Ga 68 gozetotide was evaluated in 960 patients, each receiving one dose of gallium Ga 68 gozetotide. The average injected activity was 188.7 ± 40.7 MBq (5.1 ± 1.1 mCi). No serious adverse reactions were attributed to gallium Ga 68 gozetotide. The most commonly reported adverse reactions were nausea, diarrhea, and dizziness, occurring at a rate of < 1%.
DRUG INTERACTIONS
Androgen deprivation therapy and other therapies targeting the androgen pathway
Androgen deprivation therapy (ADT) and other therapies targeting the androgen pathway, such as androgen receptor antagonists, can result in changes in uptake of gallium Ga 68 gozetotide in prostate cancer. The effect of these therapies on performance of gallium Ga 68 gozetotide PET has not been established.
You are encouraged to report suspected adverse reactions of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report adverse reactions to Telix by calling 1-844-455-8638 or via email to pharmacovigilance@telixpharma.com.
Please note this information is not comprehensive. Please see full Prescribing Information
RefleXion Media Contact:
Amy Cook
RefleXion Medical
Email: acook@reflexion.com
Telix Investor Relations
Ms. Kyahn Williamson
Telix Pharmaceuticals Limited
SVP Corporate Communications and Investor Relations
Email: kyahn.williamson@telixpharma.com
Legal Notices
This announcement may include forward-looking statements that relate to anticipated future events, financial performance, plans, strategies or business developments. Forward-looking statements can generally be identified by the use of words such as "may", "expect", "intend", "plan", "estimate", "anticipate", "outlook", "forecast" and "guidance", or other similar words. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to differ materially from any future results, levels of activity, performance or achievements expressed or implied by these forward-looking statements. Forward-looking statements are based on the Company's good-faith assumptions as to the financial, market, regulatory and other considerations that exist and affect the Company's business and operations in the future and there can be no assurance that any of the assumptions will prove to be correct. In the context of Telix's business, forward-looking statements may include, but are not limited to, statements about: the initiation, timing, progress and results of Telix's preclinical and clinical studies, and Telix's research and development programs; Telix's ability to advance product candidates into, enrol and successfully complete, clinical studies, including multi-national clinical trials; the timing or likelihood of regulatory filings and approvals, manufacturing activities and product marketing activities; the commercialisation of Telix's product candidates, if or when they have been approved; estimates of Telix's expenses, future revenues and capital requirements; Telix's financial performance; developments relating to Telix's competitors and industry; and the pricing and reimbursement of Telix's product candidates, if and after they have been approved. Telix's actual results, performance or achievements may be materially different from those which may be expressed or implied by such statements, and the differences may be adverse. Accordingly, you should not place undue reliance on these forward-looking statements.
To the maximum extent permitted by law, Telix disclaims any obligation or undertaking to publicly update or revise any forward-looking statements contained in this announcement, whether as a result of new information, future developments or a change in expectations or assumptions.
The Telix Pharmaceuticals name and logo are trademarks of Telix Pharmaceuticals Limited and its affiliates (all rights reserved).
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SOURCE Telix Pharmaceuticals Limited | https://www.14news.com/prnewswire/2022/06/10/telix-reflexion-expand-partnership-prostate-cancer-treatment/ | 2022-06-10T11:25:27Z | https://www.14news.com/prnewswire/2022/06/10/telix-reflexion-expand-partnership-prostate-cancer-treatment/ | true | 40 |
Which stove knob covers are best?
Stoves are full of things that attract and intrigue kids, including food, flames and dials, and most stove knobs are within view and reach of toddlers. It can help to buy stove knob covers to keep your child from fidgeting with the knobs on the stove and either injuring themselves or causing a fire that injures others and damages property. The Driddle Clear Stove Knob Safety Covers is a stellar set of stove knob covers.
What to know before you buy a stove knob cover
Gas vs. electric
Stove knob covers have different designs for electric stoves and gas stoves. The cover on an electric stove just needs to offer enough space to turn the knob, but the cover on a gas stove needs to keep a child from igniting the burner and releasing gas, while allowing adults to do both.
Consider the knob size and placement
You need to measure the height and diameter of your stove knobs to get the proper size.
Think about the release mechanism
There is no need to remove the entire cover when you’re ready to cook. You just need to press the release mechanism to light and adjust the stove.
What to look for in a quality stove knob cover
Heat resistance
Your cover should be made of a heat-resistant material that doesn’t melt.
Ease of removal
Your cover should be simple to remove, especially if you need to clean it.
Dishwasher safe
Find a cover model that is dishwasher safe for easy and quick cleaning.
How much you can expect to spend on a stove knob cover
Stove knob covers range in price from about $1.40-$3.50 per cover. The most inexpensive covers cost about $1.40-$2 per cover, while mid-range covers go for $2-$2.75 per cover and high-end covers vary in price from about $2.75-$3.50 per cover.
Stove knob cover FAQ
How soon will you need knob covers in your kitchen?
A. If you are currently pregnant or have a newborn infant, there is no rush to buy knob covers right away, since children don’t begin standing up until they are about 8-10 months old. And most kids don’t stand without any support until approximately 12 months, so you probably have about a year, depending on the height of your child.
That being said, some parents think it’s simpler to just have covers in place before your child actually starts walking, since if you buy covers after they’ve already played with the stove knobs, then the safety covers could be viewed as a fun and intriguing new development in the kitchen that they will want to play with.
When can you stop using knob covers?
A. This depends on your child. You can safely stop using and remove the covers when your youngest kid is old enough to follow directions and understand to stay away from the stove. This happens by age six in most kids.
By the age of six, most kids are in school and are old enough to follow directions and modify their behavior if needed, based on instructions from a parent or teacher.
What should you do if your kid hasn’t lost interest in the stove, even with the knob covers?
A. All you can do is redirect your child if they’re younger than three years of age. You can hand them a pot and a wooden spoon or a spatula and hope that they move on. If your child is between the ages of 3 and 5 years old, they can help with safe kitchen tasks, like sprinkling sugar on desserts, mixing room temperature ingredients or washing veggies.
You should make it a positive experience instead of scolding them. If you scold them, they will hold onto the experience as something negative and memorable, but if you just redirect their attention, they will probably forget about the stove the next time they walk into the kitchen.
What’s the best stove knob cover to buy?
Top stove knob cover
Driddle Clear Stove Knob Safety Covers
What you need to know: You can conveniently open these simple to use, smart-looking and clear covers with just one hand.
What you’ll love: These clear plastic covers help you see the stove controls better and will spin in your child’s hands while easily unlocking for adults. The six-pack of covers features heat-resistant material and double-button locks that can be conveniently opened with only one hand.
What you should consider: These covers won’t fit all stoves, and they can actually get in the way of the oven doors.
Where to buy: Sold by Amazon
Top stove knob cover for the money
What you need to know: These dark-tinted safety covers come from a trusted brand and specialist in child and baby products.
What you’ll love: This five-pack of covers comes with a non-adhesive attachment that is simple to remove, as well as dark and smoky plastic that obscures the controls from curious kids. The covers fit most front-facing stoves that have removable knobs and are simple to install without using any tools.
What you should consider: These covers won’t fit some stove knobs, and the hinge can break from time to time.
Where to buy: Sold by Amazon
Worth checking out
What you need to know: These clear covers are composed of transparent plastic, which gives you a clear view of all of the stove controls.
What you’ll love: This five-pack of heat-resistant plastic covers fits most front-facing stoves, and the transparency gives you a full view of the stove knobs and controls. The covers are also simple to attach without any tools and easy for you to remove.
What you should consider: These covers won’t fit recessed stove knobs, and some children can easily figure out the release mechanism.
Where to buy: Sold by Amazon
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Copyright 2022 BestReviews, a Nexstar company. All rights reserved. | https://www.yourcentralvalley.com/reviews/br/baby-kids-br/health-safety-br/best-stove-knob-covers/ | 2022-06-10T11:27:07Z | https://www.yourcentralvalley.com/reviews/br/baby-kids-br/health-safety-br/best-stove-knob-covers/ | true | 31 |
New York, June 10, 2022 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "ASEAN Electric Vehicle Market - Growth, Trends, COVID-19 Impact, and Forecast (2022 - 2027)" - https://www.reportlinker.com/p06249293/?utm_source=GNW
The COVID-19 pandemic had a negative impact on the market as manufacturing activities were on halt for several months in the first half of the year 2020. Also, the disrupted supply chain and the shortage of chips in the year 2021 had a negative impact on the growth of the market studied. The ASEAN countries are along major sea trade routes and due to the lockdown and shutdown of countries, the sea trade has also come to a halt, stopping transport of vehicles across the world. However, the gradual opening of the market in the later stages of 2020 and 2021 has paved way for economic revival of the market.
Government policies to support the growth of electric vehicles and plans to enlarge the electric vehicle charging infrastructure are expected to remain prominent market drivers during the forecast period. Several governments across the ASEAN region have announced their plans to have a certain portion of their new vehicles sales to be electric in the upcoming few years.
Governments play a vital role in encouraging the expansion of electric vehicle charging infrastructure. As the ASEAN governments push for further vehicle electrification, there must be usage and purchase incentives that either lower the overall cost of ownership or make driving electric vehicles more convenient for customers. Although there are few incentives for purchasing electric vehicles or charging infrastructure are in the Philippines, the country holds 5% and 4% of worldwide nickel and cobalt reserves, respectively, and thus has enormous potential to participate more actively in the EV battery production value chain.
EVs are becoming more popular in Indonesia, owing to ride-hailing companies like Grab, which recently announced a cooperation with local power supplier PLN to expand its fleet charging infrastructure. In the coming years, public transportation operators such as Transjakarta want to increase their electric bus fleet to 10,000 units. Such instances are evident sign for the growth of electric vehicle market across the region.
Key Market Trends
Electric Vehicle Sharing Platform will propel the Market
Vehicle sharing services in the region are updating their vehicle fleet to electric as the new startups are getting huge funding from various EV manufacturers and tech companies. Governments are also drafting various policies to increase EV adoption in the region.
According to the National Automotive Policy (NAP) of Malaysia, their initial target was to manufacture 85% of vehicles produced locally to be EVs by 2020.
Whereas in January 2020, electric vehicle ride-hailing startup Grab and Hyundai collectively launched GrabCar Elektrik. GrabCar Elektrik Service will start with the fleet of 50 Hyundai Ioniq EVs, at Jakarta’s Soekarno-Hatta International Airport and in 2019, Grab announced that company has secured around USD 1.46 billion funds from the SoftBank Vision Fund. Apart from that Grab has already raised more than $4.5 billion with investments from various automakers such as Toyota and Hyundai Motor, along with other tech giants Microsoft.
Similarly, for an electric two-wheeler, GrabWheels has secured around USD 30 million funding from KYMCO a Taiwan based electric bikes manufacturer. Through this strategic partnership, both companies will develop new two-wheeler electric vehicle solutions for faster adoption of EVs in the region.
Singapore is Expected to play key role
Singapore has been at the forefront of EV charging infrastructure in ASEAN, with more than 1,800 public charging points available. In addition, the government of Singapore is planning to install 60,000 more charging points by 2030 end.
The Singapore government has set a new target worth USD 22 million between 2021-2025 to promote EV adoption among consumers and increase the number of chargers at private properties to robust the charging infrastructure. In tandem, Singapore has successfully established itself as the key R&D hotspot for its EV industry. This, in turn, has been done by facilitating investments projects from several multinationals and start-ups companies to build a strong local EV ecosystem in Singapore.
The governments of Singapore are providing support to increase electric mobility to minimize pollution. Moreover, an increase in electric mobility is expected to increase electric vehicle sales. For instance by 2040, Singapore has planned to phase out its all-internal combustion engines and replace all of them with cleaner energy vehicles. The newly founded National Electric Vehicle Centre (NEVC) is heading the campaign to promote wider EV adoption, in accordance with Singapore’s objective for all vehicles to run on greener energy by 2040. This enables Singapore to develop new EV-related technologies in a safe and innovative manner.
Competitive Landscape
The ASEAN electric vehicle market is moderately consolidated, has several active players, owing to the presence of new startups and major conventional ICE vehicles OEMs, As the market is witnessing the entry of various electric vehicle ride-hailing startups and automakers. Some of the major players in the market are Hyundai, Tesla Inc., BMW Group, MG Motors and Mitsubishi Motor Company amongst others. The local governments are preparing for scaling up the local electric vehicle production and various automotive and ride-hailing companies are forming strategic alliances with other players in the market. For instance,
In March 2022, Hyundai Motor Group, launched its new automotive plant in Indonesia that will produce first locally assembled electric vehicle, this initiative has been the part of President Joko Widodo’s goal for developing a full EV supply chain in Indonesia.
In 2021, the Asian Development Bank and Energy Absolute signed a USD 48 million green loan valuation to finance countrywide electric vehicle charging infrastructure in Thailand.
In 2020, Thailand’s government has announced a new roadmap to promote EV through various state agencies and has set an aggressive target to manufacture around 250,000 EVs, in which 3,000 are electric buses and 53,000 electric motorcycles by 2025.
In 2018, Grab and SP Group entered into a strategic partnership. In this partnership Grab will add 200 new fast-charging electric vehicles and it will utilize SP fast-charging network. This will deliver greater cost savings for driver-partners. SP has planning to add 500 publicly accessible DC (direct current) and AC (alternating current) charging points, by 2020.
Additional Benefits:
The market estimate (ME) sheet in Excel format
3 months of analyst support
Read the full report: https://www.reportlinker.com/p06249293/?utm_source=GNW
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ReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.
__________________________
ASEAN Electric Vehicle Market - Growth, Trends, COVID-19 Impact, and Forecast (2022 - 2027)
The ASEAN Electric Vehicle Market was valued at USD 498. 93 Million in 2021 and is expected to reach USD 2,665. 3 Million by 2027, registering a CAGR of 32. 73% during the forecast period (2022 - 2027).
| Source: ReportLinker | https://www.globenewswire.com/news-release/2022/06/10/2460388/0/en/ASEAN-Electric-Vehicle-Market-Growth-Trends-COVID-19-Impact-and-Forecast-2022-2027.html | 2022-06-10T11:28:38Z | https://www.globenewswire.com/news-release/2022/06/10/2460388/0/en/ASEAN-Electric-Vehicle-Market-Growth-Trends-COVID-19-Impact-and-Forecast-2022-2027.html | false | 1 |
Growth of newer market entrants resulting in relatively flat projected share for Eli Lilly's Emgality, Teva's Ajovy, and Amgen's Aimovig
EXTON, Pa., June 10, 2022 /PRNewswire/ -- According to the latest deep dive report included in Spherix's Launch Dynamix™: Qulipta for Migraine Prevention (US) service, surveyed neurologists and migraine specialists report high satisfaction with AbbVie's Qulipta across several performance metrics early in the product's launch. However, Biohaven's Nurtec ODT is reportedly up to par with Qulipta on most attributes, including overall efficacy, safety, tolerability, and favorable dosing schedule.
In fact, Nurtec ODT outperforms Qulipta on ease of market access and breadth of approved indications. Respondents anticipate robust six-month projected market share for both products, with a 50% increase for Nurtec ODT and more than 250% for Qulipta.
Despite some early success indicators for Qulipta, the brand trails Eli Lilly's Emgality, Teva's Ajovy, and Amgen's Aimovig in familiarity, degree of advance, and user base at the same post-launch time frame. On the other hand, Qulipta matches the anti-CGRP brands in aided and unaided awareness of launch and outpaces the competitors in terms of overall satisfaction (time-aligned to respective launches).
The preventive and acute migraine treatment landscape is poised for further disruption as Biohaven's zavegepant (currently in Phase III) is being studied for prevention in nasal spray form and for acute in capsule form. Spherix's RealTime Dynamix™: Migraine (US) is a quarterly service which examines migraine therapies in development from Phase II and later in addition to ongoing tracking of the market.
In addition to covering the US market, a new EU5 RealTime Dynamix™ service will debut in Q3 of 2022. The EU5 market will be exciting to watch with Biohaven's Vydura (Nurtec ODT in the US) recently gaining approval and Qulipta expected to be approved sometime in 2023. Further, Pfizer's planned acquisition of Biohaven brings a completely different dynamic to the migraine market.
Launch Dynamix™ is an independent service providing monthly benchmarking of newly launched products for the first eighteen months of commercial availability, augmented by a quarterly deep dive into promotional activity, barriers to uptake, and patient types gravitating to the launch brand.
Spherix Global Insights is a hyper-focused market intelligence firm that leverages our own independent data and expertise to provide strategic guidance, so biopharma stakeholders make decisions with confidence. We specialize in select dermatology, gastroenterology, nephrology, neurology, ophthalmology, and rheumatology markets.
All company, brand or product names in this document are trademarks of their respective holders.
For more information contact:
Frank Franzino, Migraine Insights Director
Email: [email protected]
www.spherixglobalinsights.com
SOURCE Spherix Global Insights | https://www.prnewswire.com/news-releases/biohavens-nurtec-odt-and-abbvies-qulipta-emerging-as-the-top-two-contenders-in-the-preventive-migraine-space-according-to-spherix-global-insights-301565518.html | 2022-06-10T11:28:52Z | https://www.prnewswire.com/news-releases/biohavens-nurtec-odt-and-abbvies-qulipta-emerging-as-the-top-two-contenders-in-the-preventive-migraine-space-according-to-spherix-global-insights-301565518.html | true | 2 |
PHILADELPHIA — On the day Donnie Hart nearly died, he crawled from the wreckage of a single-car accident and inched along for hours with a broken jaw and shattered leg to get help.
“He doesn’t have the word “quit” in his vocabulary,” Hart’s football coach said after the crash in 2005.
In many ways, that wreckage haunted Hart for years to come. An opioid prescription for the pain devolved into an addiction and when his beloved brother, Jimmy, died unexpectedly in 2014, the former semipro wrestler known as “Reckless” Donnie Hart turned to crime — robbing pharmacies — for even more pills.
Last Friday morning, almost seven years after robbing a Haddonfield CVS and carjacking a retired priest. Hart, 34, walked into the Camden County courthouse to finally report to prison. He was a different man, facing a drastically different sentence.
“I just want to thank the court for showing me mercy,” Hart told Superior Court Judge Kurt Kramer.
Attorney Richard Klineburger said Hart had originally been looking at 100 years, and probably would have served 50.
“He was basically going to prison for life,” he said.
Instead, after a lengthy negotiation with the Camden County Prosecutor’s Office, Hart was sentenced to eight years in state prison, a term that could be reduced to as little as four months with time served and possible acceptance into an intensive supervision program.
“Thank you so much,” Hart’s tearful father, Jim, said to Klineburger after the sentencing.
Last week, Hart told The Inquirer he’d already put himself on his own, makeshift supervision since his arrest July 28, 2015. Hart hasn’t been arrested since and is sober. He works full-time for a friend’s solar power company but is most proud of his weekly podcast and nonprofit, Hungry4Hope, a show that aims to “give hope to the hopeless” with uplifting stories about topics like fighting illnesses and addiction.
“I’m the most grateful guy ever and I’m putting my foot on the gas pedal, you know, because I was given a second chance here,” Hart said at the podcast studio before recording last month.
Every Wednesday, Hart and his co-host, Angela Melchiorre, would sit down at Toxic Radio in Gloucester Township, Camden County, and bring on guests from all over the country. Hart was a guest on the Hungry4Hope podcast just before the pandemic unfolded, and found sharing his story therapeutic. He later became a host. On this Wednesday night, Hart was recording episode 93. One guest, Jim Raffone, raises money to research treatments for Duchenne muscular dystrophy; Raffone’s son suffers from the disin ease. Another guest, Richard Jensen, returned to the sport of wrestling and became a champion after battling addictions, prison time, and living in shelters for over a decade.
“We all need a little shred of inspiration and hope,” Jensen said.
“If that’s not the understatement of the decade,” Melchiorre replied.
Melchiorre is fighting stage four lung cancer and recently underwent her eighth round of chemotherapy.
While pro wrestling training has a bit of theatrics, Hart’s a natural on the mic. He laughed, checked in often with Melchiorre, and didn’t interrupt the guests.
“You can take your worst days and use them to find your best days,” Hart told Raffone before the podcast was over.
Hart, who stands 6-foot-3, with a frame north of 250 pounds, once dreamed of playing football in the NFL. On Dec. 19, 2005, he fell asleep driving home from a friend’s home and crashed into a creek. It took him two hours to crawl to help. Hart said the doctor he saw, Alan Summers, overprescribed him opioids and he developed an addiction. Summers is now in federal prison for drug distribution, health-care fraud, and money laundering.
In 2014, Hart’s older brother, James, died, on a backpacking trip in Cambodia. After the loss of his brother, he said, the painkiller use spiraled into something he couldn’t manage.
On June 16, 2015, Hart, a Mantua, Gloucester County native, robbed a Haddonfield Rite Aid at gunpoint and carjacked a retired priest. He was arrested a month later at a convenience store in Cherry Hill and charged with robbery, aggravated assault, and weapons offenses. The first plea agreement prosecutors offered him was 40 years.
“Either way, there was a good chance I would die in prison,” he said.
When this reporter visited Hart at the Camden County jail after the arrest in 2015, he was still sporting the mohawk he wore as “Reckless Donnie Hart” in the wrestling ring. He was jittery and nervous that day and brought up his brother’s death often. He also proclaimed his innocence — though give Hart’s size, it would be hard to confuse him with the average person.
“It was a dark year for me,” he says now. “I was self-destructive. I wanted to destroy everything.”
Hart served just under two years in the Camden County jail and the Montgomery County jail, under additional charges. As court hearings crawled along and were eventually delayed altogether by the COVID-19 pandemic, Hart made real changes on his own. Prosecutors took notice.
“I think people thought that ‘hey, if he’s been out this long and hasn’t gotten in any trouble, what’s the point of putting him away for 40 years,’ “ said Joe Enright, Hart’s close friend and boss at the solar power company.
Susan Pastore used to write letters to Hart while he was incarcerated. He was friends with her son, Jon, and she wanted him to know he wasn’t alone.
“Everyone has worth and value and I needed him to know that,” Pastore said.
In the future, Hart hopes to become a public speaker and feels his message might resonate with teens and children, particularly boys, who might see his size, the tattoos snaking up and down his arms, and realize anyone can suffer.
“You know, I’m this big, brawny football player and wrestler and I have mental anguish, too,” he said. “I think if they hear from someone like me, someone putting all their own garbage on the table, it could mean a lot.”
Hart will be missing from the podcast while he’s in prison but he already planned on temporary guest hosts. Then he’ll return to the microphone, to keep sharing his story.
He said only part of him will be in that prison cell, because, finally, he feels free. | http://www.virginislandsdailynews.com/ap/i-wanted-to-destroy-everything-former-semipro-wrestler-from-south-jersey-rallies-after-descent-into/article_75a87360-9428-59f6-ba14-e851b87dadb2.html | 2022-06-10T11:36:01Z | http://www.virginislandsdailynews.com/ap/i-wanted-to-destroy-everything-former-semipro-wrestler-from-south-jersey-rallies-after-descent-into/article_75a87360-9428-59f6-ba14-e851b87dadb2.html | true | 2 |
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When I found out Neighbours had been cancelled, I cried so much my husband thought someone had died
I’m autistic – to me, I’m not just losing a TV show, I’m losing my life’s most constant and reliable comfort
It is the news I’d hoped would never come: after 37 years on screen, the Australian soap opera Neighbours has been cancelled. The cast have even shared a photo of the filming of the final episode on set.
When I first found out the show was ending, my sobs were so loud and guttural that my husband tripped up the stairs running to me, assuming somebody had died.
I understand if you think this is the kind of melodrama worthy of the soap itself. There are so many terrible things in the world that the loss of one silly little soap doesn’t seem earth-shattering. But for me, that’s exactly what it is. I’m not just losing a TV show – I’m losing my life’s most constant and reliable comfort.
I have been watching Neighbours since before I had a television of my own. I grew up in a new-age community where TV was up there with the societal ills of microwave ovens and medical science. We had a TV set but it wasn’t hooked up to anything. It spent most of its time hidden under a silk cloth, topped with crystals (either to ward off evil spirits or so my parents could tell if I’d sneaked a verboten peek).
I happened upon Neighbours at my godparents’ house on the day that Madge, iconic wife of even more iconic Harold, died. While the high drama of a character being killed off is what hooked me in, that’s not why I stuck around. I was transfixed by the cheery, Australian brightness, the gentle everyday-ness of it and the familiarity of characters who began to feel like friends.
For an undiagnosed autistic kid, it was hard to put a value on friends who would be there every day no matter what. The characters on Neighbours weren’t just there for one another, as the theme song promised – they were there for me. The least I could do was be there for them in return. Come hell or high water, I started making sure I was at a TV-owner’s house every afternoon at five-thirty-five, whether I’d been invited or not. Usually the latter.
Being autistic almost certainly played into the level of obsession that was to follow. Autistic people tend to have what are commonly known as special or focus interests, where we spend an extraordinary amount of time thinking or learning about one thing. Neighbours has taken up an embarrassing amount of my brain space since I was thirteen years old.
Not long afterwards, my parents’ divorce resulted in the acquisition of an actual television – hooked up to an aerial and everything. The real deal. While we adjusted to life without my dad, Neighbours became my comfort blanket. And it has remained so through every traumatic life event, providing safety and security when my real life couldn’t.
When I left my childhood behind and moved across the country to go to university, Neighbours came with me. I staked my claim on the timeslot, making sure to plant myself in front of the common room TV in good time, like a sunbather leaving their towel on the good deckchair.
When it moved to Channel 5, I resorted to desperate measures to ensure I never missed an episode, waiting hours for pixelated and permanently buffering episodes to load on my primitive Internet connection.
Through housemate dramas and devastating dumpings, I could always rely on Susan rolling her eyes at Dr Karl, or Toadie’s inexplicable luck with the ladies to get me through. Years later, as I sat by my dying father’s bedside at the age of 25, I obsessively rewatched clips from classic episodes. They were my light in the darkness.
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As I got older, I started to feel self-conscious about my Neighbours fixation and declared myself to be an “ironic” viewer. It wasn’t long before I stumbled upon the Facebook group, The Art of Neighbours, a community of seriously funny folks who would comment on the latest ludicrous storylines through the medium of Microsoft Paint art.
Through that, I found the side-splitting Neighbours recap podcast, Neighbuzz, and became a proud member of their Facebook group. Through these groups I’ve made some of my most precious friends. Logging on to read their hot takes has become an irreplaceable daily ritual. I even guest starred on a live London Neighbuzz recording, getting to meet much of my Neighbours-loving fam in person.
Losing the show is a body blow. While I pray that it will be picked up by another network, the outlook isn’t good. But as corny as it sounds, what started as a stand-in for real friends helped me to find my people.
The outpouring of shared grief at the news has reassured me that those relationships aren’t going anywhere. Neighbours may be over but the people it has brought into my life are here to stay – and that’s quite the legacy.
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Want to bookmark your favourite articles and stories to read or reference later? Start your Independent Premium subscription today. | https://www.independent.co.uk/voices/neighbours-finish-uk-finale-filming-b2098203.html | 2022-06-10T11:48:56Z | https://www.independent.co.uk/voices/neighbours-finish-uk-finale-filming-b2098203.html | false | 1 |
On Thursday, June 9, 2022, at 1:00 p.m., a school administrator at Thomas Stone High School was advised that a student was in possession of a knife and a stun gun, which were recovered.
The school resource officer is conducting an investigation and, upon completion, will review the case with the State’s Attorney’s Office regarding criminal charges.
Anyone with information about this incident is asked to contact Officer L. Payne at 301-609-3282 Ext. 0452. Tipsters who want to remain anonymous, but provide information about threats or criminal activity at schools may contact the confidential tip line at CCPS at 301-302-8305 or Charles County Crime Solvers at 1-866-411-TIPS. | https://smnewsnet.com/archives/506499/police-recover-knife-and-stun-gun-from-thomas-stone-high-school-student/ | 2022-06-10T11:50:48Z | https://smnewsnet.com/archives/506499/police-recover-knife-and-stun-gun-from-thomas-stone-high-school-student/ | true | null |
Published: Updated On - 02:41 PM, Fri - 10 June 22
Hyderabad: The Hayathnagar police on Friday arrested a Bharatiya Janata Party leader from Ghatkesar on charges of defaming government schemes with false accusations on Chief Minister K.Chandrashekhar Rao and the government with a malicious intention to mislead the people and provoke hatred and unrest.
The arrested person was J.Bala Krishna Reddy from Ghatkesar.
On June 2, in view of the State Formation Day, the BJP state unit under the leadership of State President Bandi Sanjay and organisers J.Balakrishna Reddy, Rani Rudrama and others organised an event and misused the dais by putting up a skit with the help of BJP cultural team – Boddu Yellanna in an insulting manner against the CM. The same was also telecasted by various vernacular news channels, police said.
A complainant with this regard was lodged by Y. Sathish Reddy, TRS Social Media Convenor at the Hayathnagar PS, after which a case was booked against Bandi Sanjay, Jitta Balakrishna Reddy, Rani Rudrama, Boddu Yellanna alias Daruvu Yellanna and others.
After examination of the videos and other evidence in hand, it was concluded the event was organised to make derogatory comments, personal attacks, depicting the Chief Minister in bad light, police said.
Now you can get handpicked stories from Telangana Today onTelegrameveryday. Click the link to subscribe. | https://telanganatoday.com/defamation-of-cm-kcr-govt-case-booked-against-bjp-leaders-one-arrested | 2022-06-10T11:53:45Z | https://telanganatoday.com/defamation-of-cm-kcr-govt-case-booked-against-bjp-leaders-one-arrested | false | 2 |
Isle of Man TT: 'We won't stop until we win' - Crowe brothers
Last updated on .From the section Motorsport
Finishing a sidecar race at the Isle of Man TT is "emotional no matter where you come", say the Crowe brothers.
Ryan and Callum Crowe secured their first podium finish in Monday's rescheduled sidecar race one, behind the Birchall brothers.
Although the Manx pairing said they had been "surprised" by their speed in the race, driver Ryan admitted the ultimate goal was to reach the top spot.
"We're not going to stop until we win it," the Manxman added.
The pair rose to prominence in 2019 when they set a speed of 113.53mph in their first-ever lap, making them the event's fastest-ever newcomers.
They started the 2022 meeting with only four laps under their belts.
The sons of five-time TT sidecar champion Nick Crowe had mixed fortunes when they made their debut on the 37.73-mile Mountain Course in 2019, securing fifth place in the first race but withdrawing from the second due to a mechanical issue.
Passenger Callum said the pair had not had the "best luck last week in practice" this year either with disruption to qualifying week due to red flag incidents and inclement weather, meaning the brothers had managed a total of just nine laps by the end of race one.
Looking back at that race, he said: "I was a bit shocked at the lap time, that was the bit that shocked me the most.
"It think we did 115mph in practice, and then when we eventually got a flying lap it was a 118.5mph.
"It was fast, but it was comfortable at the same time, it didn't feel like it was on the edge just yet, I think he's still got a bit more to come, so let's see how we get on in the next race."
'The worst drug you can ever take'
Although keeping an eye on the competition, bettering their own performance in sidecar race two was the main focus, Ryan added.
"I don't really want to race anybody, I want to race myself, I race my own last time, I just want to beat myself last time is the thing," he said.
"And we've done that so far, every time we've gone out there we've gone a little bit quicker, we haven't come back going slower yet. That's when you start getting anxious, if you start going slower."
Reflecting on the draw of the Isle of Man TT, Callum said: "I think it's the worst drug you can ever take. There's no other feeling like it I don't think, I've never come across a feeling like it in my life.
"The adrenalin you get out of it, and when you go down Glencrutchery Road and you cross that start line.
"It's very emotional when you finish round here, first, second, 10th, last, it doesn't matter - you still completed the races." | https://www.bbc.co.uk/sport/motorsport/61759934 | 2022-06-10T11:55:23Z | https://www.bbc.co.uk/sport/motorsport/61759934 | false | 3 |
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iSHARES TRUST (Form497)
Accepted:
Form Type:
497
Accession Number:
0001193125-22-165206 | https://www.benzinga.com/secfilings/22/06/27511862/ishares-trust-form497 | 2022-06-10T12:00:06Z | https://www.benzinga.com/secfilings/22/06/27511862/ishares-trust-form497 | true | 254241 |
Sylvamo Co. (NYSE:SLVM – Get Rating) shares traded down 4.8% during mid-day trading on Wednesday . The company traded as low as $47.87 and last traded at $48.77. 2,601 shares were traded during trading, a decline of 99% from the average session volume of 339,385 shares. The stock had previously closed at $51.25.
A number of equities analysts have issued reports on the stock. Royal Bank of Canada raised shares of Sylvamo from a “sector perform” rating to an “outperform” rating and raised their price target for the stock from $40.00 to $43.00 in a research report on Thursday, April 7th. Zacks Investment Research lowered shares of Sylvamo from a “buy” rating to a “hold” rating in a research report on Thursday, April 14th. Finally, Bank of America assumed coverage on shares of Sylvamo in a research report on Friday, March 25th. They set a “neutral” rating for the company.
The company has a debt-to-equity ratio of 4.05, a quick ratio of 1.16 and a current ratio of 1.71. The firm’s fifty day moving average price is $43.32 and its two-hundred day moving average price is $36.03.
The company also recently announced a — dividend, which will be paid on Friday, July 15th. Stockholders of record on Friday, June 17th will be issued a dividend of $0.1125 per share. The ex-dividend date is Thursday, June 16th.
In related news, major shareholder Paper Co /New/ International sold 4,132,000 shares of the business’s stock in a transaction on Thursday, April 21st. The shares were sold at an average price of $34.75, for a total value of $143,587,000.00. Following the completion of the sale, the insider now owns 4,614,358 shares of the company’s stock, valued at approximately $160,348,940.50. The sale was disclosed in a legal filing with the SEC, which is available through this hyperlink. 0.33% of the stock is owned by insiders.
A number of hedge funds and other institutional investors have recently modified their holdings of SLVM. BlackRock Inc. increased its holdings in Sylvamo by 37,501.9% in the 4th quarter. BlackRock Inc. now owns 4,779,205 shares of the company’s stock worth $133,292,000 after acquiring an additional 4,766,495 shares in the last quarter. First Trust Advisors LP acquired a new stake in Sylvamo during the 1st quarter worth $69,597,000. Atlas FRM LLC acquired a new stake in Sylvamo during the 4th quarter worth $49,515,000. State Street Corp acquired a new stake in Sylvamo during the 4th quarter worth $45,020,000. Finally, Pictet Asset Management SA acquired a new stake in Sylvamo during the 4th quarter worth $22,723,000. 82.83% of the stock is owned by institutional investors.
About Sylvamo (NYSE:SLVM)
Sylvamo Corporation produces and supplies printing paper in Latin America, Europe, and North America. The company offers uncoated freesheet for paper products, such as cutsize and offset paper; and markets pulp, aseptic, and liquid packaging board, as well as coated unbleached kraft papers. It also produces hardwood pulp, including bleached hardwood kraft and bleached eucalyptus kraft; bleached softwood kraft; and bleached chemi-thermomechanical pulp.
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Receive News & Ratings for Sylvamo Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Sylvamo and related companies with MarketBeat.com's FREE daily email newsletter. | https://www.tickerreport.com/banking-finance/8944609/sylvamo-nyseslvm-trading-down-4-8.html | 2022-06-10T12:01:10Z | https://www.tickerreport.com/banking-finance/8944609/sylvamo-nyseslvm-trading-down-4-8.html | true | 1 |
Suspected drug dealers have been charged after armed police swooped in Nuneaton. Passers-by in Cheveral Street were left stunned when armed police swarmed on a car in the street.
Officers pounced and several arrests were made on Wednesday, June 8. The suspects were taken into custody and further warrants were carried out.
Four men were due to appear at Coventry Magistrates’ Court today. Their names and the corresponding charges are listed below.
READ MORE:Public plea to find wanted man with links to Coventry
Dean Frankton, 45, of Norman Road, Nuneaton, has been charged with:
- Possession with intent to supply crack cocaine
- Possession with intent to supply heroin
- Concerned in the supply of heroin
- Concerned in the supply of crack
Shakane Stabler, 25, of Corporation Street, Coventry, has been charged with:
- Possession with intent to supply crack cocaine
- Possession with intent to supply heroin
- Concerned in the supply of heroin
- Concerned in the supply of crack
- Possession of cannabis
- Acquire criminal property
Mark Bowman, 48, from Whitley village in Coventry, has been charged with:
- Possession with intent to supply crack cocaine
Possession with intent to supply heroin
Naomi Sheppard, 25, of St Augustine's Walk, Coventry, has been charged with:
Possession with intent to supply crack cocaine
Possession with intent to supply heroin
Possession with intent to supply cannabis
- Supply of cannabis
- Acquire criminal property | https://www.coventrytelegraph.net/in-your-area/suspected-coventry-nuneaton-drug-dealers-24182927 | 2022-06-10T12:04:53Z | https://www.coventrytelegraph.net/in-your-area/suspected-coventry-nuneaton-drug-dealers-24182927 | false | 1 |
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Former Love Islander Chris Hughes has defended 19-year-old Gemma Owen on the show, after she received criticism for ‘rude’ behaviour and viewers taking issue with the sizeable age difference between Gemma and Davide Sanclimenti, aged 27.
Gemma, the daughter of ex-footballer Michael Owen, certainly made her presence felt during the launch of the new series, with her ‘rude’ comments towards Luca Bish after coupling up with Liam Lewellyn and making a bee-line for Italian stallion Davide, despite him being eight years her senior.
However, ex-Love Islander Chris – who was coupled up with Olivia Atwood on the series in 2017 – has defended Gemma’s age and behaviour.
Speaking exclusively to Metro.co.uk, Chris, who is currently supporting the 150th Open Championship Claret Jug Tour in partnership with HSBC UK, said: ‘Everyone’s different. You can meet 18, 19, 20-year-olds who are very mature, and they can be more grown up than a 28-year-old.’
He added that he ‘can’t judge somebody’ without knowing their personality, but referring to backlash Gemma faced for being ‘rude’ after her behaviour towards fellow islander Luca about his surname, Chris shared: ‘I feel like Gemma handled herself like an adult, she has strong opinions on things she likes and dislikes and I think that’s fair enough, we’re individuals.
‘Everyone’s going to have their different opinions on things. If she doesn’t like somebody’s surname she doesn’t like somebody’s surname, that doesn’t define her as a person.’
He continued: ‘Somebody’s not her natural type, that’s fair enough. I think people forget, like fair play have a strong personality because if you’re going on there to find love and you’re saying that’s not my type, she’s on there to find someone she wants to be with.
‘I feel like a lot of people forget the basis of the show, like you get entertainment along the way but she’s obviously sticking to her guns and I don’t see what’s wrong with that.
‘She got a lot of criticism for being dismissive but she’s on there to find love and for the actual basis of the show, I feel like people have forgotten that that’s what the show is actually about.’
Chris, who left the Love Island villa and became a sports presenter, working with broadcasters including BBC, ITV and Sky Sports, on a range of sporting events covering golf, cricket and horse-racing, admitted he didn’t follow the ‘natural steps’ that other ex-Love Islanders do when they rise to fame.
He told us: ‘To be a part of the 150th Open, part of the tour of the Claret Jug, is a real honour. It’s a real privilege, for me it’s the most iconic trophy in golf. Love Island is where I got my platform, where people knew me from, it gave me so many opportunities, especially working with golf. I’m obviously grateful for Love Island for the platform, it’s been a massive help for me, you’ve got to grasp those opportunities.’
Chris continued: ‘It’s not the natural steps but it’s natural to me, that’s why at first it takes people a bit of time to teach people that side of you, you’ve got to convert people first because opinions can be quite brutal, but I’m there for a reason.’
He added: ‘If someone said to me, “I’ve been asked to go on Love Island or I’m thinking about applying and what’s the benefits and what’s the negatives”, I’d say “You’re opening up yourself to opinions”. I’d always tell people to be themselves, I was always myself.
‘You can see when people aren’t themselves and they try to be someone else because over a long period of time it doesn’t last, the character you’re trying to be.
‘Obviously for me it’s been very positive, I’ve taken a lot of opportunities, I’ve been able to have a platform and discuss things like mental health, and my brother’s testicular cancer and raise awareness for that, so it’s given me a platform where I can do a lot of positive with it.’
Chris Hughes is supporting The 150th Open Claret Jug Tour, in partnership with HSBC UK, visiting schools, golf clubs, city centres and HSBC branches as it makes its way across the UK and Ireland, ending at St Andrews for The Open in July.
For more information about The 150th Open Claret Jug Tour visit TheOpen.com and follow @TheOpen and @HSBC_UK on social media.
Love Island continues tonight at 9pm on ITV.
Got a story?
If you’ve got a celebrity story, video or pictures get in touch with the Metro.co.uk entertainment team by emailing us celebtips@metro.co.uk, calling 020 3615 2145 or by visiting our Submit Stuff page – we’d love to hear from you.
MORE : Inside Love Island star Gemma Owen’s dressage career
MORE : Love Island’s Liam Llewellyn also has a former sports star father, just like Gemma Owen
Love Island 2022 latest
Kiss goodbye to your social life - Love Island is back to dominate your evenings, with the new series promising more drama than ever before.
- Full Love Island 2022 line-up
- Love Island launch episode review: Cringe-worthy moments but we’re not swiping left yet
- I went to the new Love Island villa and the reality is not what I expected
- Which Love Island couples are still together?
For all the latest updates, visit Metro.co.uk's Love Island page. | https://metro.co.uk/2022/06/10/love-island-chris-hughes-defends-gemma-owen-after-rude-beheaviour-16793526/ | 2022-06-10T12:08:58Z | https://metro.co.uk/2022/06/10/love-island-chris-hughes-defends-gemma-owen-after-rude-beheaviour-16793526/ | true | 1 |
- Fusion to invest $5M for guaranteed access to actinium-225 supply
- Agreement augments Fusion's existing supply as company expands pipeline of actinium-based radio pharmaceuticals
HAMILTON, ON and BOSTON and LANSING, Mich., June 10, 2022 /PRNewswire/ -- Fusion Pharmaceuticals Inc. (Nasdaq: FUSN), a clinical-stage oncology company focused on developing next-generation radio pharmaceuticals as precision medicines, and Niowave, Inc., a manufacturer of medical radioisotopes from radium and uranium, today announced that the companies have entered into a collaboration and supply agreement for the development, production, and supply of actinium-225. Under the agreement, Fusion will invest up to $5 million in Niowave to further develop their technology to increase current production capacity of actinium-225, and in return Fusion will have guaranteed access to a pre-determined percentage of Niowave's capacity of the resulting actinium-225, as well as preferred access to any excess supply produced. As part of the agreement, Fusion will also have an option to invest in future production of actinium-225 to scale with Fusion's needs.
"As excitement for the tumor-killing potential of alpha-emitting radio pharmaceuticals increases, we intend to stay at the forefront of actinium development and supply to support our growing pipeline of targeted alpha therapies," said Fusion Chief Executive Officer John Valliant, Ph.D. "We continue to prioritize manufacturing and access to actinium as a critical component of Fusion's platform, and our partnership with Niowave further strengthens and diversifies our supply chain as we advance multiple actinium-based radio pharmaceuticals in the clinic."
"The Niowave team has worked hard to scale up our actinium-225 production to the millicurie level and this has allowed us to start working with oncology community partners," said Niowave Chief Executive Officer/Senior Scientist Terry Grimm, Ph.D. "We have been watching Fusion's progress in the development of their pipeline of targeted alpha therapies and we are very excited to partner with them on this journey."
Fusion is developing actinium-based TATs leveraging the potency and precision offered by alpha particles. Actinium-225 decay gives off four alpha emissions in relatively rapid succession, maximizing the damage to the DNA of tumor cells, with a 10-day half life that allows for central manufacturing and distribution of products to clinical sites in a ready-to-use form.
Fusion currently has existing actinium supply arrangements with TRIUMF and the U.S. Department of Energy (DOE).
Fusion Pharmaceuticals is a clinical-stage oncology company focused on developing next-generation radiopharmaceuticals as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules in order to selectively deliver the alpha emitting payloads to tumors. Fusion's lead program, FPI-1434 targeting insulin-like growth factor 1 receptor, is currently in a Phase 1 clinical trial. The pipeline includes FPI-1966, targeting the fibroblast growth factor receptor 3 (FGFR3), advancing to a Phase 1 study following the investigational new drug (IND) clearance; and FPI-2059, a small molecule targeting neurotensin receptor 1 (NTSR1). In addition to a robust proprietary pipeline, Fusion has a collaboration with AstraZeneca to jointly develop novel targeted alpha therapies (TATs) and combination programs between Fusion's TATs and AstraZeneca's DNA Damage Repair Inhibitors (DDRis) and immuno-oncology agents. Fusion has also entered into a collaboration with Merck to evaluate FPI-1434 in combination with Merck's KEYTRUDA® (pembrolizumab) in patients with solid tumors expressing IGF-1R. Fusion and Hamilton, Ontario-based McMaster University are building a current Good Manufacturing Practice (GMP) compliant radiopharmaceutical manufacturing facility designed to support manufacturing of the Company's growing pipeline of TATs.
Niowave manufactures radioisotopes to cure cancer and save lives. Niowave builds and operates superconducting electron linear accelerators and is using that expertise to produce various radioisotopes for nuclear medicine. Niowave is a Cooperative Agreement partner with the National Nuclear Security Administration to develop a domestic supply of molybdenum-99 and currently produces yttrium-90 for use in cancer therapy. Niowave is licensed by the NRC to manufacture radioisotopes from uranium and radium and has partnerships with several universities and national laboratories focused on production and purification of radioisotopes for use in cancer therapy. By using radium targets and electron beams, Niowave is able to produce ultra pure (>99.9%) and carrier-free actinium-225. Niowave's R&D facility is currently supplying actinium-225 samples to partners. Production-scale operations are ramping up at a second, FDA-compliant facility capable of meeting the growing actinium-225 market.
This press release contains "forward-looking statements" for purposes of the safe harbor provisions of The Private Securities Litigation Reform Act of 1995, including but not limited to the statements regarding Fusion Pharmaceuticals Inc.'s (the "Company") future business and financial performance. For this purpose, any statements contained herein that are not statements of historical fact may be deemed forward-looking statements. Without limiting the foregoing, the words "expect," "plans," "anticipates," "intends," "will," and similar expressions are also intended to identify forward-looking statements, as are expressed or implied statements with respect to the Company's potential access to actinium-225. Actual results may differ materially from those indicated by such forward-looking statements as a result of risks and uncertainties, including but not limited to the following: there can be no guarantees that the Company or its partners will advance any technology relating to actinium-225 to development, to the regulatory process or to commercialization; management's expectations could be affected by unexpected regulatory actions or delays; and uncertainties relating to, or unsuccessful results of, clinical trials, clinical trial timelines and the medical isotopes used therein. Such forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause actual results to be materially different from any future results, performance or achievements expressed or implied by such statements. These and other risks which may impact management's expectations are described in greater detail under the heading "Risk Factors" in the Company's quarterly report on Form 10-Q for the period ended March 31, 2022, as filed with the SEC and in any subsequent periodic or current report that the Company files with the SEC. All forward-looking statements reflect the Company's estimates only as of the date of this release (unless another date is indicated) and should not be relied upon as reflecting the Company's views, expectations, or beliefs at any date subsequent to the date of this release. While Fusion may elect to update these forward-looking statements at some point in the future, it specifically disclaims any obligation to do so, even if the Company's estimates change.
Fusion Contact:
Amanda Cray
Senior Director of Investor Relations & Corporate Communications
617-967-0207
cray@fusionpharma.com
Niowave Contact:
Denise Boucke
Director, Human Resources & Administration
517-999-3475
Boucke@niowaveinc.com
View original content to download multimedia:
SOURCE Fusion Pharmaceuticals Inc. | https://www.ky3.com/prnewswire/2022/06/10/fusion-pharmaceuticals-niowave-announce-actinium-225-collaboration-supply-agreement/ | 2022-06-10T12:11:15Z | https://www.ky3.com/prnewswire/2022/06/10/fusion-pharmaceuticals-niowave-announce-actinium-225-collaboration-supply-agreement/ | true | 12 |
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Key Statistics | https://www.benzinga.com/quote/MIFTF/short-interest | 2022-06-10T12:18:15Z | https://www.benzinga.com/quote/MIFTF/short-interest | true | 254241 |
HARTFORD — Michigan State Police are investigating an alleged shooting and unlawful imprisonment that occurred Wednesday morning in Hartford Township.
Police arrested a 41-year-old man, following the incident in the 62000 block of 63rd Street.
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HARTFORD — Michigan State Police are investigating an alleged shooting and unlawful imprisonment that occurred Wednesday morning in Hartford Township.
Police arrested a 41-year-old man, following the incident in the 62000 block of 63rd Street.
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Email notifications are only sent once a day, and only if there are new matching items. | https://www.heraldpalladium.com/news/michigan-state-police-investigate-shooting-in-hartford-township/article_9851bc88-8d9f-55bf-8a0c-3cef4a28ee59.html | 2022-06-10T12:18:38Z | https://www.heraldpalladium.com/news/michigan-state-police-investigate-shooting-in-hartford-township/article_9851bc88-8d9f-55bf-8a0c-3cef4a28ee59.html | false | 10 |
Casualty spoilers follow.
Casualty has officially confirmed when its missing episode will air, following a BBC review.
As we've previously reported, this Saturday's edition, titled 'Wednesday's Child', was pulled just days before broadcast earlier this week.
The 80-minute special, focusing on Ollie Hide's shocking storyline, was initially meant to air on Saturday, June 11, but will now air a week later than originally planned on Saturday, June 18.
The update comes just a week after the BBC announced the episode was under review and said in a statement to Digital Spy: "In light of recent tragic news events, we are reviewing the episode of Casualty due to transmit on 11th June on BBC One."
The BBC's statement was referring to the devastating shooting which recently took place at Robb Elementary School in Uvalde, Texas, where 21 people, including 19 children, were killed and 18 further people were injured.
Before being removed, the BBC's original synopsis for the episode read: "David must come to terms with Ollie's involvement in a school shooting, and a patient from Paul's past pushes him to be honest with Robyn."
Another episode named 'By Any Means’ focusing on Paige and Rash's story, is now due to broadcast tomorrow night (June 11) instead.
The synopsis for this episode reads: "Rash (Neet Mohan) helps a father reconnect with his disaffected teenager while struggling to do the right thing for Paige (Shalisha James-Davis). Meanwhile, Robyn (Amanda Henderson) steps up to help Marty (Shaheen Jafargholi) and Adi (Raj Bajaj) with their surrogacy."
Viewers know Ollie has been the subject of some bullying at school recently, and his behaviour has been causing increasing concern.
The last time we saw him, Ollie was acting strangely and had seemingly made a sinister plan with his school friend Rob.
Casualty airs on Saturday nights on BBC One and streams on BBC iPlayer.
Read more Casualty spoilers on our dedicated homepage | https://www.digitalspy.com/soaps/casualty/a40251037/casualty-spoilers-shooting-episode-air-date/ | 2022-06-10T12:22:09Z | https://www.digitalspy.com/soaps/casualty/a40251037/casualty-spoilers-shooting-episode-air-date/ | true | 1 |
Tech After going for Apple in podcasts, now Spotify is going for Amazon with audiobooks: this is its new strategy By Kim Diaz - June 10, 2022 0 Share Facebook Twitter Pinterest WhatsApp After going for Apple in podcasts, now Spotify is going for Amazon with audiobooks: this is its new strategy | https://thenewstrace.com/after-going-for-apple-in-podcasts-now-spotify-is-going-for-amazon-with-audiobooks-this-is-its-new-strategy/235362/ | 2022-06-10T12:25:05Z | https://thenewstrace.com/after-going-for-apple-in-podcasts-now-spotify-is-going-for-amazon-with-audiobooks-this-is-its-new-strategy/235362/ | true | null |
Online troll convicted of sending 'hanging from a tree monkey boy' racist death threat to Labour MP David Lammy is 12-time Conservative election candidate
- Glenn Broadbent, 62, was fined £2,000 after sending racist message to the MP
- The 12-time Tory election candidate used a pseudonym to tweet David Lammy
- The Shadow Foreign Secretary contacted police, leading to Broadbent's arrest
An online troll who was convicted of sending a racist death threat to Labour MP David Lammy has been revealed as a 12-time Conservative election candidate.
Glenn Broadbent, 62, was fined £2,000 in May after he admitted using a pseudonym to send a racist message to the Tottenham MP on Twitter.
Shadow Foreign Secretary Mr Lammy said the revelation raises 'serious questions' for the Tories to answer.
In the tweet, Broadbent wrote: 'Are you hanging from a tree monkey boy? You will hang from a lamppost if you are not careful.'
Mr Lammy then highlighted the message to his followers and asked police to investigate the matter, leading to Broadbent's arrest.
Glenn Broadbent, 62, was fined £2,000 in May after he admitted using a pseudonym to send a racist message to the Tottenham MP on Twitter
And following his conviction, it has emerged that Broadbent had stood for election to Leeds Council as a Tory candidate on 12 occasions over the past 40 years.
He was also quoted as a spokesperson for his local branch of the party last summer.
After Broadbent's political affiliations were revealed, Mr Lammy said yesterday it was 'despicable' that he'd been allowed to run for office.
He said: 'It's truly despicable that a 12-time Conservative candidate sent me a racist death threat.
'This raises serious questions for the Conservatives about the prevalence of anti-Black racism in their party.'
A spokesperson for the Conservative party said: 'Mr Broadbent is no longer a member of the Conservative Party. We utterly deplore these comments.'
Labour MP David Lammy said yesterday it was 'despicable' that Glenn Broadbent had been allowed to run for office
Broadbent said he was 'deeply ashamed' of his behaviour and the distress he had caused to Mr Lammy and confirmed he had resigned from the party.
Mr Lammy highlighted the distressing tweet in August 2020 to his 750,000 social media followers, where he asked police to investigate and said, 'Vile racists will not silence me.'
Two months later, he called out Twitter founder Jack Dorsey, claiming officers couldn't look into the matter as the social media company had 'refused to assist in their investigation'.
Broadbent was later convicted on May 27 this year for sending a message which was grossly offensive and menacing, contrary to the Communications Act 2003.
And along with his fine, he was given a 12-month suspended sentence, ordered to pay court costs and banned from contacting Mr Lammy in the future.
But after he was sentenced, public records revealed he unsuccessfully stood for election to Leeds Council, West Yorkshire, on 12 occasions between 1983 and 2008.
In June last year, he was also quoted as a spokesperson for the Farnley and Wortley Conservatives in an online story about a consultation on the relocation of a local Post Office.
In a statement issued after his conviction, Broadbent said there was 'no excuse' for his behaviour and said he resigned from the Tory Party six days before the court hearing.
He wrote: 'This offence was committed almost two years ago, I cannot recall the exact circumstances other than I was in drink and was browsing Twitter.
'There can be no excuse for my behaviour.
Broadbent said that there can be 'no excuse' for his behaviour and is 'deeply ashamed' of the offence
'I am deeply ashamed of the offence and the distress caused to David Lammy MP, his family and any other persons who were offended by my message.
'Considering the recent murder of Sir David Amess MP, I realise how irresponsible and disgusting my actions were.
'No public servant should be subjected to such behaviour and there are no excuses for my behaviour. I extend my sincere apologies to David Lammy MP.
'I know members of Leeds City Conservative Federation will be disgusted by my behaviour and rightly so.
'I also know that the members I know are good people trying their best to help their communities. My comments have no place in an open, inclusive and diverse Conservative Party.'
Broadbent, who admitted using a pseudonym to send a racist message to the Tottenham MP on Twitter, described his actions as 'irresponsible and disgusting'
In 2008, during the run-up to a local by-election, Broadbent attracted national attention due to his controversial Facebook posts.
In one he wrote: 'Proud to be English and sick of paying tax to support lazy people, imported spongers and subsidising the Scots and the Welsh'.
After criticism by Welsh politicians, he issued an apology 'for any offence caused' and said there was 'certainly no intention to do so'.
Following Broadbent's sentencing, Chief Superintendent Damien Miller of West Yorkshire Police said: 'No-one should have to endure the kind of disgusting racist abuse that was directed at Mr Lammy.
'Members of Parliament can be particular targets for threats and abuse, either directly or online, and we continue to work closely with them and their staff to safeguard and reassure them as they carry out their vital public duty.'
The Conservative Party has been approached for further comment. | https://www.dailymail.co.uk/news/article-10903897/Online-troll-convicted-sending-racist-death-threat-Labour-MP-12-time-Tory-candidate.html?ns_mchannel=rss&ns_campaign=1490&ito=1490 | 2022-06-10T12:25:44Z | https://www.dailymail.co.uk/news/article-10903897/Online-troll-convicted-sending-racist-death-threat-Labour-MP-12-time-Tory-candidate.html?ns_mchannel=rss&ns_campaign=1490&ito=1490 | false | 3 |
Areas of Spain close to the nation's popular Costa del Sol holiday resorts have been evacuated because of wildfires. Around 3,000 people were forced from properties west of Malaga as flames swept through the region.
The blaze reportedly started on Wednesday afternoon on the slopes of Pujerra mountain in the Sierra Bermeja close to the Andalusia coast with temperatures soaring into the 30s C and tinder-box dry conditions. Strong winds also helped the flames spread and restricted efforts of firefighters, local TV stations reported.
Spain's military emergency unit has also been drafted in to assist with efforts to control the fire. residents were instructed to leave their homes in the small town of Benahavis, where around 5,000 ex-pat Britons reside. The blaze-hit area is also close to popular resorts of Torremolinos, Marbella, Mijas, Benalmádena, Estepona and Fuengirola where thousands of UK holidaymakers spend their summer breaks.
Flames and smoke were visible from the popular tourist areas of Estepona and Marbella with visibility hampering efforts to control the inferno. Charlotte Albutt tweeted: “We are currently in Isdabe where an ash cloud has begun to cover the sky and drop small pieces of ash.”
Sinead Doran tweeted: “Plumes of apocalyptic smoke over Estepona this evening blocking the sun. Really strange light.”
Three firefighters have already suffered burns. Temperatures are expected to soar into the 40s C in the coming days.
For more stories from where you live, visit InYourArea. | https://www.walesonline.co.uk/news/world-news/british-expats-evacuated-costa-del-24193431 | 2022-06-10T12:26:36Z | https://www.walesonline.co.uk/news/world-news/british-expats-evacuated-costa-del-24193431 | true | 2 |
ABERDEEN, SD (GC.com) – Jamestown. The Smittys slipped past Jamestown in extra innings last night, 6-5. The teams were originally slated to play a DH, but changed it to a 9-inning game…except that it ended up going extras. Had the game been a 7inn contest, Aberdeen would’ve had a 4-3 win. Either way, Aberdeen improved to 13-8 on the season with the walk-off victory. Jaiden Smith picked up the win, tossing 4inn of hitless relief while whiffing three & walking four. Brian Holmstrom allowed three unearned runs in the start, lasting 5inn and giving up 7H w/ 2K & 3BB. Holmstrom also plunked two, while Smith hit one. At the dish, Drew Salfrank went 2/5 w/ 2R & a walk; Nick Clemens was 3/5 w/ a run & 2RBI; and Casey Vining had a 1/4 night w/ 2R, an RBI, and a walk. Clemens & Vining also stole two bags each, while Salfrank swiped a ridiculous five bases. | https://www.newsbreak.com/news/2629292608173/mosquito-spraying-scheduled-for-wednesday | 2022-06-10T12:26:54Z | https://www.newsbreak.com/news/2629292608173/mosquito-spraying-scheduled-for-wednesday | true | 1 |
LOS ANGELES, May 31, 2022 (GLOBE NEWSWIRE) -- ( ENOB) - Enochian BioSciences is working to solve our greatest public health threats like HIV, cancer, and coronavirus. The company’s underlying scientific ideas are innovative with an elegant simplicity, characteristics that are often a hallmark of groundbreaking advances. The company is working to push through systems and barriers to translate these innovative ideas into potential products that could save lives.
Prominent scientific leaders agree on the promise of Enochian BioSciences’ approach and are working to carry out studies that will drive new therapies forward:
Dr. Philippe Gallay, Professor of Immunology and Microbiology, Scripps Research: “I was attracted to Enochian by some of the most innovative scientific ideas I had seen in my more than 35 years as a Researcher. I have performed independent, pivotal laboratory and animal studies on the HIV, Hepatitis B and SARS-CoV-2 pipelines of Enochian BioSciences and have seen the very promising data for myself. Indeed, I have been an author on abstracts reviewed, accepted and presented at several important scientific conferences. I am enthusiastic about further collaborations with the Company.”
Dr. Anahid Jewett, a renowned tumor immunologist and cell and gene therapy investigator at UCLA: “My laboratory has conducted key studies demonstrating that Enochian BioSciences’ approach to solid tumors, starting with pancreatic cancer, induces a remarkably strong and broad immune response that could translate into potential life-saving therapy for many people. I look forward to beginning animal studies soon and to further work with Enochian.”
Dr. Rich Whitley, Distinguished Professor of Pediatrics, Professor of Microbiology, Medicine and Neurosurgery and Loeb Eminent Scholar Chair in Pediatrics of the University of Alabama: “As the Chairperson of the Respiratory Diseases Scientific Advisory Board, I have been very impressed by the novel approach and the current data generated by independent scientific collaborators to potentially kill any variant SARS-CoV-2 and Influenza in the nose and mouth. That is important not only to potentially protect infected people from illness, but also to potentially prevent spread of the virus and even to be used as prophylaxis in households and among other close contacts. I have been very impressed by the focus and speed with which Enochian’s Management has moved. With new variants of SARS-CoV-2 circulating that could be resistant to existing vaccines and therapies, I very much look forward to continuing to advise Enochian BioSciences as the Company moves as rapidly as possible to develop potential products and advance towards human studies.”
Forward-Looking Statements
Statements in this press release that are not strictly historical in nature are forward-looking statements. These statements are only predictions based on current information and expectations and involve a number of risks and uncertainties, including but not limited to the success or efficacy of our pipeline. All statements other than historical facts are forward-looking statements, which can be identified by the use of forward-looking terminology such as “believes,” “plans,” “expects,” “aims,” “intends,” “potential,” or similar expressions. Actual events or results may differ materially from those projected in any of such statements due to various uncertainties, including as set forth in Enochian BioSciences’ most recent Annual Report on Form 10-K filed with the SEC. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement, and Enochian BioSciences undertakes no obligation to revise or update this press release to reflect events or circumstances after the date hereof.
Contact: [email protected]
Source: Enochian Biosciences | https://www.gurufocus.com/news/1751675/scientific-leaders-agree-on-promise-of-enochian-biosciences | 2022-06-10T12:32:47Z | https://www.gurufocus.com/news/1751675/scientific-leaders-agree-on-promise-of-enochian-biosciences | true | 4 |
Dynamite (DYNMT) traded up 4.4% against the US dollar during the 1-day period ending at 7:00 AM Eastern on June 10th. During the last seven days, Dynamite has traded 13.7% lower against the US dollar. Dynamite has a market cap of $7,043.83 and approximately $43,516.00 worth of Dynamite was traded on exchanges in the last day. One Dynamite coin can now be bought for $0.0183 or 0.00000061 BTC on popular cryptocurrency exchanges.
Here is how related cryptocurrencies have performed during the last day:
- HEX (HEX) traded 1.8% lower against the dollar and now trades at $0.0530 or 0.00000177 BTC.
- Quant (QNT) traded down 1.9% against the dollar and now trades at $62.85 or 0.00209658 BTC.
- Zilliqa (ZIL) traded 3% lower against the dollar and now trades at $0.0481 or 0.00000160 BTC.
- MXC (MXC) traded down 0.8% against the dollar and now trades at $0.0833 or 0.00000278 BTC.
- DXdao (DXD) traded 0.3% lower against the dollar and now trades at $609.56 or 0.02033367 BTC.
- Vectorspace AI (VXV) traded 1.4% higher against the dollar and now trades at $0.70 or 0.00002342 BTC.
- PARSIQ (PRQ) traded 2.7% lower against the dollar and now trades at $0.12 or 0.00000413 BTC.
- Qubitica (QBIT) traded flat against the dollar and now trades at $11.94 or 0.00025016 BTC.
- Egoras Dollar (EUSD) traded flat against the dollar and now trades at $1.15 or 0.00003616 BTC.
- TouchCon (TOC) traded 2.2% lower against the dollar and now trades at $0.0513 or 0.00000171 BTC.
Dynamite Coin Profile
According to CryptoCompare, “DYNMT is an open-source, community-based and focused social experiment. Participation in this experiment does not provide an offer of ordinary shares of any asset, and token holders are not entitled to or promise d any dividend / financial reward. The tokens are not designed to create securities under any jurisdiction. The world's first feature of Dynamite token is that 2% is burned forever with every transfer. The Dynamite Token project is intended as an academic study. All data from this experiment will be presented to the public via reports. “
Buying and Selling Dynamite
It is usually not presently possible to buy alternative cryptocurrencies such as Dynamite directly using US dollars. Investors seeking to acquire Dynamite should first buy Bitcoin or Ethereum using an exchange that deals in US dollars such as Gemini, GDAX or Coinbase. Investors can then use their newly-acquired Bitcoin or Ethereum to buy Dynamite using one of the aforementioned exchanges.
Receive News & Updates for Dynamite Daily - Enter your email address below to receive a concise daily summary of the latest news and updates for Dynamite and related cryptocurrencies with MarketBeat.com's FREE CryptoBeat newsletter. | https://www.wkrb13.com/2022/06/10/dynamite-dynmt-achieves-market-capitalization-of-7043-83.html | 2022-06-10T12:37:42Z | https://www.wkrb13.com/2022/06/10/dynamite-dynmt-achieves-market-capitalization-of-7043-83.html | true | 17 |
Fatman Scoop to perform at Bongos Bingo this July
Put Your Hands Up for a wild night out…
The second installment of Dubai’s brilliantly bonkers Bongos Bingo is happening at Atlantis The Palm next month. But not just a five-round bingo rave, this top night out will come with a live performance from Fatman Scoop.
Tickets are priced at Dhs150 and available now via platinumlist.net.
For those that need a little refresh, Fatman Scoop (real name Isaac Freeman III) is a rapper and producer with one of the most recognisable voices in the business. In the late nineties and early noughties, he churned out floor-filling hits including Be Faithful, Put Your Hands Up and It Takes Scoop, and also collaborated with megastars like Whitney Houston, Mariah Carey and Janet Jackson. The American rapper has performed all over Dubai, previously headlining shows at Toy Room, Cavalli (RIP both) and Barasti.
View this post on Instagram
If you’re not familiar with the concept, it’s just like normal bingo in the sense that numbers will be called and participants need to score a row to win prizes. What makes Bongo’s Bingo different to the type that your grandparents play, are the seemingly random prizes (think Henry the Hoover, cardboard cut-outs of your favourite day time television presenter, and giant fluffy unicorns).
The summer series of Bongos Bingo Dubai kicked off this June at Atlantis The Palm with a nostalgia-packed performance from S Club Party. More bingo dates – as well as some brilliant throwback artists – are set to be announced soon.
If past events are anything to go by, you’ll need to be quick if you want to get your hands on tickets. Bingo-lovers, show yourselves…
Bongo’s Bingo Dubai, Atlantis The Palm, 8pm onwards, Friday July 1, Dhs150. @bongosbingodubai | https://whatson.ae/2022/06/fatman-scoop-to-perform-at-bongos-bingo-this-july/ | 2022-06-10T12:38:18Z | https://whatson.ae/2022/06/fatman-scoop-to-perform-at-bongos-bingo-this-july/ | false | 1 |
This cute home near Toronto is on sale for only $79K
Usually when you hear the term "mobile home" you think of something from the Trailer Park Boys. But with outrageous housing costs and soaring rent prices, mobile homes are becoming more and more in demand for those looking for housing alternatives.
Also mobile homes aren't what they once were. Take this one-bedroom, one-bathroom mobile home in Caledon, just over an hour from Toronto. It's downright adorable!
Listed for just $79,000, the home is nestled in a lush part of Terra Cotta Conservation Area.
It's been renovated with new vinyl siding, newer shingles, and updated plumbing, electrical and insulation.
The interior is modern, with a sleek white kitchen, bamboo counter tops and stainless steel appliances.
The main living space has vaulted ceilings, a wood burning stove and walk-out to the deck.
The bedroom and bathroom are compact but fit the essentials.
There's also a little office nook, which realtor Janice Rumley notes in the listing could be used as a walk-in closet.
The park fees, according to the listing, are $990 a year and that gets you access to the inground pool and other ammenities the park has to offer like a pond filled with fish.
The slight catch is one: this home isn't actually mobile; and two: the park is only open from April 30 - October 30 with partial access during the off-season. So it's not really a year-round home.
But it could be ideal as a vacation home. It's certainly cheaper than any Muskoka cottage.
Join the conversation Load comments | https://www.blogto.com/real-estate-toronto/2022/06/14221-winston-churchill-blvd-caledon/ | 2022-06-10T12:38:54Z | https://www.blogto.com/real-estate-toronto/2022/06/14221-winston-churchill-blvd-caledon/ | true | 1 |
A recently published study by the University of Cambridge finds a definitive link between a person's music preferences and their personality type. More to the point, this link appears universal across many different cultures.
For example, Ed Sheeran's song "Shivers" is as likely to appeal to extroverts living in the UK as those who live in Argentina or India. Americans with self-defined neurotic traits gravitate to Nirvana's "Smells Like Teen Spirit" in South Africa or Denmark. Conscientious people all over the world hate Rage Against the Machine.
Without much variation, the researchers found positive correlations between extroverts and contemporary music, conscientiousness and unpretentious music, agreeableness and mellow music, and between openness and intense music.
Fascinating. And, also, DUH.
You could learn as much hanging out at Co-Op Records in Moline.
I guess it proves different cultures can find common musical ground, but only if you're hanging out with like-minded people in those different cultures. Did they think there's a magical foreign land where conscientious folks all sit around listening to death metal while neurotics prefer smooth jazz? Personally, I'm pretty sure smooth jazz CAUSES neurosis (make me listen to Kenny G. and I promise I'll be neurotic by nightfall.)
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Supposedly these are the most widely accepted traits today for classifying personalities, but I don't consider myself to be especially extroverted, conscientious, agreeable, stable, OR open. Maybe that's why my list of favorite bands tends to be met by blank stares from anyone who's not a complete weirdo.
I followed the link that allows you to replicate the study in the privacy of your home. The website plays snippets of 25 songs, and you have to choose whether you extremely, very much, moderately, or slightly like or dislike each song clip.
Spoiler alert: I disliked all 25 of them -- a lot. Some were classical, and that's just not my bag. Others sounded like bad Nickelback knock-offs. One was just a laughably corny guitar solo. Another was a country song with the lyric, "somebody shot my neighbor today." There was a clip that sounded like the demo on a Casio keyboard. Another was a bland beat with someone yelling "ungh!" over it like your uncle doing James Brown karaoke. They were all dreadful.
The survey didn't reveal much about me. My preference for "contemporary" music was highest of all, likely because I only "moderately hated" those, as opposed to everything else which I "very much hated."
Maybe you can define someone's personality by their musical taste, but there's sure exceptions to the rule. One of my friends is very much an agreeable conscientious introvert. He also listens to nothing but Black Sabbath and 70s prog rock -- explain THAT, Cambridge. I own a lot of pretentious Radiohead records, but I also own just as many records by Lisa Lisa & Cult Jam. Musical tastes can be unique as snowflakes, and that's a GOOD thing in my book.
One thing about this study, though, is a success: It certainly helped me kill time on the internet. Now if you'll excuse me, I need to go listen to some mellow contemporary music because I'm so gosh-darn agreeable. | https://qctimes.com/lifestyles/shane_brown/shane-brown-theres-a-link-between-musical-preferences-and-personality-type-well-duh-you-dont/article_14f87e9f-4f27-568b-b79f-5f5781b0516c.html | 2022-06-10T12:42:06Z | https://qctimes.com/lifestyles/shane_brown/shane-brown-theres-a-link-between-musical-preferences-and-personality-type-well-duh-you-dont/article_14f87e9f-4f27-568b-b79f-5f5781b0516c.html | true | 1 |
NEW YORK, June 10, 2022 /PRNewswire/ -- Olshan Frome Wolosky LLP announced that the firm has been recognized by The Legal 500 US in its 2022 edition as a Leading Law Firm. The Shareholder Activism practice has been ranked as a Tier One practice, a position it has held since the rankings' inception, including seven of the practice's attorneys. The Advertising practice has also again been ranked along with three attorneys. The rankings are based on feedback from clients, peers and The Legal 500's independent research.
It is notable that once again, The Legal 500 only ranked five attorneys in the nation as "Leading Lawyers" in the area of Shareholder Activism – Advice to Shareholders, and that three of them are Olshan partners. Client testimonials are expansive, noting that, "The Olshan team brings both deep and broad experience in the activist space. They are thoughtful, creative, and extremely responsive."
- Leading Lawyers: Steve Wolosky, Andrew Freedman, Elizabeth Gonzalez-Sussman
- Next Generation Partner: Ryan Nebel
- Recommended Lawyer: Kenneth Mantel
- Key Lawyers: Meagan Reda, Sebastian Alsheimer
The firm has also been ranked as a Tier 3 Leading Firm in Advertising and Marketing: Transactional and Regulatory, with chair Andrew Lustigman and partner Tamara Carmichael named as "Recommended Lawyers" and partner Scott Shaffer recognized as a "Key Lawyer." Client testimonials note that the team is, "…efficient, thorough, and highly professional."
To view the full details of Olshan's rankings in the 2022 edition of The Legal 500 US, please see Olshan or Legal 500 US 2022.
About Olshan
Olshan Frome Wolosky LLP, a law firm based in New York, represents major businesses and entrepreneurs in their most significant transactions, problems and opportunities. Olshan's clients range from public companies, hedge, venture capital, private equity and other investment funds to entrepreneurs and private companies worldwide. Clients choose Olshan for innovative strategies and sophisticated, game-changing advice in corporate, securities law, equity investment and shareholder activism, complex commercial, corporate and securities litigation, real estate, intellectual property, bankruptcy and creditors' rights, and advertising. Since its founding, Olshan has offered an alternative to the AmLaw 50 law firm business model with responsive, independent and client-focused legal counsel provided by the firm's senior lawyers.
Contact:
Madelaine Miller Strauss
mmillerstrauss@gmail.com
646.331.2691
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• Scania is introducing complete BEV-based solutions for regional long-haul
• With power, range and charging capacity for effortless daily operations
• Scania continues along its electrification roadmap journey to reach the set Science-Based Targets for CO2 reduction, in partnership with customers.
SÖDERTÄLJE, Sweden, June 10, 2022 /PRNewswire/ -- True to its stated roadmap, Scania is now introducing solutions built upon the next level of battery-electric trucks (BEV). The new generation, available with R or S sleeper cabs, is part of a complete solution that will open the door to the electrified transport landscape wide for a vast number of customers and app-lications. With 624 kWh of batteries installed, Scania provides the means for a major shift regarding electric trucks and their operability in regional long-haul operations.
"This introduction represents a major milestone for us and for our partners," says Christian Levin, Scania's CEO. "We are now increasing our range in every dimension by offering new opportunities for a vast selection of customers and the whole transport ecosystem. These trucks are part of solutions that contain all the capabilities that a transport industry longing for electrification is asking for."
Scania's new BEV truck generation is based on classic Scania cornerstones such as modularity, sustainability and a total operating economy with the potential to match or even exceed what can be expected from conventional trucks. And the latest electric Scania trucks are accompanied by all the support with operational factors and services that make them complete solutions, with charging, finance, insurance and maintenance all in place.
"The addition of these solutions to Scania's portfolio is a major step-change for customers who want to take charge," says Fredrik Allard, Senior Vice President and Head of Electrification at Scania. "We are facilitating a transition for our customers by including important customer values such as a close partnership and zero emissions."
With the new Scania trucks, customers will be able to operate rigids or tractor-and-trailer combinations such as temperature-controlled food transports. Ranges vary with weight, configuration and topography, but a 4x2 tractor with six batteries can expect up to 350 km between each charging, with an average speed of 80 km/h on motorways. Fixed routes that provide for planned charging at the home depot or at the destination are most favourable. Opportunity charging during the driver's man-datory 45 minutes rest will of course increase the operative range.
"Scania has now reached a favourable maturity regarding our electrified offer," says Allard. "With this major addition to our existing hybrids and the BEVs for urban distribution we introduced in 2020, we can now offer a sustainable and multi-faceted portfolio of zero-emission solutions for our customers."
The new Scania BEV trucks can initially be ordered as 4x2 tractors or as 6x2*4 rigids. A 4x2 tractor will need an axle distance of 4,150 mm when carrying six batteries, thus benefiting from the Increased Vehicle Dimension regulation in Europe. Gross train weights up to 64 tons, as per the typical Nordic combination, can be specified.
The charging capability is up to 375 kW, which means that an hour of charging will add some 270 to 300 km of range, as a rule of thumb. The continuous power output level for a Scania 45 R or S is 410 kW (equivalent to some 560 hp). The next-level Scania electrified trucks can now be ordered by taking up a dialogue with Scania representatives, and production will commence in Q4 2023.
"Tackling the global CO2 challenges means that we all need to produce and consume in new ways," says Levin. "Reduce, reuse and recycle have always been important for Scania. The only thing that stands between us and a major transition to a fossil-free transport system based on electrified solutions is a complete charging infrastructure, but we are seeing great progress there too."
The availability of charging solutions is indeed crucial for European customers who want to start investing in BEV trucks on a greater scale. Scania has teamed up with global partners, and with Scania as the single point of contact, they can offer complete charging solutions that secure a seamless and future-proofed experience for BEV customers.
Find more information in this video and at scania.com/bev
For more information, please contact:
Örjan Åslund, Head of Product Affairs, Scania Trucks
Telephone: +46702898378, E-mail: orjan.aslund@scania.com
This information was brought to you by Cision http://news.cision.com
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SOURCE Scania | https://www.wtok.com/prnewswire/2022/06/10/scania-introduces-electric-trucks-regional-long-haul/ | 2022-06-10T12:44:08Z | https://www.wtok.com/prnewswire/2022/06/10/scania-introduces-electric-trucks-regional-long-haul/ | false | 22 |
Aditya Roy Kapur unleashes his action avatar in 'Om: The Battle Within'
The wait is finally over! The much-anticipated trailer of Aditya Roy Kapur-starrer 'Om
- Country:
- India
The wait is finally over! The much-anticipated trailer of Aditya Roy Kapur-starrer 'Om: The Batlle Within' was unveiled on Friday and it's no less than a feast for the eyes. The trailer begins with Prachi Shah crying about losing one son in a fire, and the other facing a memory loss. Then we see Jackie Shroff as a nuclear scientist expressing the importance of a nuclear test. Unfortunately, he gets arrested for allegedly betraying the country. Ashutosh Rana then marks his entry and introduces protagonist Aditya Roy Kapur's character with a voice-over, "This mission can be completed by only one warrior, and his name is Om. Aditya then enters and unleashes his action avatar.
However, while fighting enemies, he ends up losing his memory. We are then told that he is the son of Jackie. The trailer ends with him promising himself to protect his father's honour and the nation's pride. "Rakth rahe ya na rahe rashtra humesha rahega," Aditya concluded the trailer by delivering this dialogue in his intense voice.
Aditya's ripped muscles and action-packed avatar have left the audience in awe of his look. "Oh My God! He is looking killer," a social media user commented.
"Amazing transformation. Can't take my eyes off Aditya, " another one wrote. "Whistle-worthy performance," a netizen commented.
Helmed by Kapil Verma, 'Om: The Battle Within' also features Sanjana Sanghi, Ashutosh Rana, and Prakash Raj. Bank-rolled by Zee Studios and Ahmed Khan, the film will hit cinema halls on July 1. (ANI)
(This story has not been edited by Devdiscourse staff and is auto-generated from a syndicated feed.)
- READ MORE ON:
- Aditya
- Zee Studios
- Aditya Roy Kapur
- Jackie
- Rana
- Prakash Raj
- Ahmed Khan | https://www.devdiscourse.com/article/entertainment/2068440-aditya-roy-kapur-unleashes-his-action-avatar-in-om-the-battle-within | 2022-06-10T12:46:41Z | https://www.devdiscourse.com/article/entertainment/2068440-aditya-roy-kapur-unleashes-his-action-avatar-in-om-the-battle-within | false | 2 |
Senior activities offered in Crestline, Galion
CRESTLINE – The Crawford County Council on Aging has a calendar full of senior activities this month, including some taking place in Crestline and Galion. Planned for Crestline this month at the Crestline Community Center, 143 W. Bucyrus St. is a patriotic social. The Stars and Stripes Social will be from...
www.galioninquirer.com | https://www.newsbreak.com/news/2629306525273/senior-activities-offered-in-crestline-galion | 2022-06-10T12:47:55Z | https://www.newsbreak.com/news/2629306525273/senior-activities-offered-in-crestline-galion | true | null |
Editors: From today, we have started issuing daily jute and jute goods prices as well as foodgrains, jaggery & sugar, and oil & vanaspati prices from Kolkata. We have also started releasing weekly tea reports. These stories will be available on our CCM file.
Editors From today, we have started issuing daily jute and jute goods prices as well as foodgrains, jaggery sugar, and oil vanaspati prices from Kolkata. These stories will be available on our CCM file. These are in addition to the daily bullion market reports that we have been sending.
- Country:
- India
Editors: From today, we have started issuing daily jute and jute goods prices as well as foodgrains, jaggery & sugar, and oil & vanaspati prices from Kolkata. We have also started releasing weekly tea reports. These stories will be available on our CCM file. These are in addition to the daily bullion market reports that we have been sending.
(This story has not been edited by Devdiscourse staff and is auto-generated from a syndicated feed.)
- READ MORE ON:
- foodgrains
- jaggery & sugar
Advertisement | https://www.devdiscourse.com/article/headlines/2068393-editors-from-today-we-have-started-issuing-daily-jute-and-jute-goods-prices-as-well-as-foodgrains-jaggery-sugar-and-oil-vanaspati-prices-from | 2022-06-10T12:47:55Z | https://www.devdiscourse.com/article/headlines/2068393-editors-from-today-we-have-started-issuing-daily-jute-and-jute-goods-prices-as-well-as-foodgrains-jaggery-sugar-and-oil-vanaspati-prices-from | false | null |
Global AI in Enterprise Accounting Market Insights and Forecast to 2028
AI in Enterprise Accounting market is segmented by players, region (country), by Type and by Application. Players, stakeholders, and other participants in the global AI in Enterprise Accounting market will be able to gain the upper hand as they use the report as a powerful resource. The segmental analysis focuses on revenue and forecast by Type and by Application for the period 2017-2028.
Segment by Type
Table of content
1 Report Business Overview
1.1 Study Scope
1.2 Market Analysis by Type
1.2.1 Global AI in Enterprise Accounting Market Size Growth Rate by Type, 2017 VS 2021 VS 2028
1.2.2 Cloud-based
1.2.3 On Premise
1.3 Market by Application
1.3.1 Global AI in Enterprise Accounting Market Size Growth Rate by Application, 2017 VS 2021 VS 2028
1.3.2 Large Enterprises
1.3.3 Small and Medium-sized Enterprises (SMEs)
1.4 Study Objectives
1.5 Years Considered
2 Global Growth Trends
2.1 Global AI in Enterprise Accounting Market Perspective (2017-2028)
2.2 AI in Enterprise Accounting Growth Trends by Region
2.2.1 AI in Enterprise Accounting Market Size by Region: 2017 VS 2021 VS 2028
2.2.2 AI in Enterprise Accounting Historic Market Size by Region (2017-2022)
2.2.3 AI in Enterprise Accounting Forecasted Market Size by Region (2023-2028)
2.3 AI in Enterprise Accounting Market Dynamics
2.3.1 AI in Enterprise Accounting Industry Trends
2.3.2 AI in Enterprise Accounting Market Drivers
2.3.3 AI in Enterprise Accounting Market Challenges
2.3.4 AI in Enterprise Accounting Market Restraints
3 Competition Landscape by Key Players
3.1 Global Top AI in Enterprise Accounting Players by Revenue
3.1.1 Global Top AI in Enterprise Accounting Players by Revenue (2017-2022)
3.1.2 Global AI in Enterprise Accounting Revenue Market Share by
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Global Enterprise Accounting Software Market Insights, Forecast to 2028
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Global and Japan Enterprise Accounting Software Market Size, Status and Forecast 2021-2027 | https://galleonnews.com/uncategorized/302601/global-ai-in-enterprise-accounting-market-insights-and-forecast-to-2028-2/ | 2022-06-10T12:48:02Z | https://galleonnews.com/uncategorized/302601/global-ai-in-enterprise-accounting-market-insights-and-forecast-to-2028-2/ | true | 590 |
Updated results for talquetamab monotherapy and in combination with daratumumab highlighted in oral presentations at the 2022 EHA Annual Congress
VIENNA, June 10, 2022 /PRNewswire/ -- The Janssen Pharmaceutical Companies of Johnson & Johnson announced updated results from the Phase 1 MonumenTAL-1 first-in-human dose-escalation study of talquetamab (NCT03399799), an investigational, off-the-shelf, T-cell redirecting bispecific antibody targeting both GPRC5D, a novel multiple myeloma target, and CD3 on T-cells.1 Results from the study showed encouraging responses in heavily pretreated patients with relapsed or refractory multiple myeloma (RRMM) who received talquetamab at the recommended subcutaneous Phase 2 dose (RP2D) administered weekly (QW) or every two weeks (Q2W).2 These data will be featured during the 2022 European Hematology Association (EHA) Annual Congress as an oral presentation on Saturday, June 11 (Abstract S182)2 and were recently presented at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting (Abstract #8015).3
No new safety signals were identified with longer follow-up of either dose cohort.2 The most common adverse events (AEs) at the 405 µg/kg QW dose were cytokine release syndrome (CRS; 76.7 percent; 3.3 percent Grade 3/4), neutropenia (66.7 percent; 60 percent Grade 3/4), skin-related AEs (66.7 percent; all Grade 1/2), and dysgeusia (63.3 percent; all Grade 1/2).2
The most common AEs at the 800 µg/kg Q2W dose were CRS (79.5 percent; all Grade 1/2), skin-related AEs (72.7 percent; 2.3 percent Grade 3/4), and dysgeusia (56.8 percent).2 Dysgeusia (altered sense of taste) was managed with supportive care and, if needed, dose adjustments.2 Cytopenias were mostly confined to step-up doses and cycles one and two and generally resolved within one week.2 Infections occurred in 46.7 percent (Grade 3/4, 6.7 percent) of patients at the 405 μg/kg QW dose and 38.6 percent (Grade: 3/4, 9.1 percent) at the 800 μg/kg Q2W dose 2
Step-up dosing was used to mitigate against severe CRS, and pre-treatment medications (including steroids) were limited to the step-up and first full doses.2
"Patients with multiple myeloma who are heavily pretreated need new options," said Monique Minnema, M.D., Professor, Department of Hematology, University Medical Center, Utrecht, Netherlands, and principal study investigator.† "The continued deep and durable responses and tolerable safety profile seen in these longer-term data suggest that at both doses, talquetamab may offer a new treatment option for relapsed or refractory patients."
The overall response rate (ORR) to talquetamab treatment was consistent across both doses.2 With a median follow-up of 13.2 months (range 1.1-24), 70 percent (21/30) of response-evaluable patients treated with the 405 µg/kg QW dose achieved a response, 56.7 percent achieved a very good partial response (VGPR) or better, 6.7 percent achieved a complete response (CR), and 23.3 percent achieved a stringent complete response (sCR). With a median follow-up of 7.7 months (range 0.7-16), 63.6 percent (28/44) of response-evaluable patients treated with the 800 µg/kg Q2W dose achieved a response, 56.8 percent achieved a VGPR or better, 11.4 percent achieved a CR, and 9.1 percent achieved an sCR. The median duration of response (DOR) was 10.2 months (95 percent Confidence Interval (CI): 3.0–not estimable) with the 405 µg/kg QW dose and 13.0 months (95 percent CI: 5.3–not estimable) with the 800 µg/kg QW dose.2
Among response-evaluable patients who were triple-class refractory, a response was achieved by 65.2 percent (15/23) of patients treated with the 405 µg/kg QW dose and 67.6 percent (23/34) of patients treated with the 800 µg/kg Q2W dose.2 In patients who were penta-drug refractory, 83.3 percent (5/6) of patients treated with the 405 µg/kg QW dose and 75 percent (9/12) of patients treated with the 800 µg/kg Q2W dose achieved a response.2
"With additional follow-up, these data demonstrate potential durability of talquetamab responses," said Sen Zhuang, M.D., Ph.D., Vice President, Clinical Research and Development, Janssen Research & Development, LLC. "We look forward to fully understanding the potential of this bispecific for relapsed and refractory patients through ongoing clinical development."
The primary objectives of the MonumenTAL-1 study were to identify the recommended subcutaneous Phase 2 dose (part 1) and assess the safety and tolerability of talquetamab at the recommended dose (part 2).2 As of April 6, 2022, 130 patients with multiple myeloma who had relapsed or were refractory or intolerant to established therapies have received talquetamab in the study.2 For part 2, 30 patients received the weekly RP2D of 405 µg/kg QW dosing schedule following step-up doses; 100 percent were triple-class exposed, 80 percent were penta-drug exposed, 76.7 percent were triple-class refractory, 20 percent were penta-drug refractory, and 30 percent had prior B-cell maturation antigen (BCMA)-directed therapy.2 Forty-four patients received the RP2D of 800 µg/kg Q2W; 97.7 percent were triple-class exposed; 68.2 percent were pentadrug exposed, 77.3 percent were triple-class refractory, 27.3 percent were penta-drug refractory, and 27.3 percent had prior BCMAdirected therapy.2
Updated data from the Phase 1b TRiMM-2 Study Evaluating Talquetamab in Combination with DARZALEX FASPRO® (Abstract S183)
Additional data for talquetamab will be featured in an oral presentation at EHA on Saturday, June 11 (Abstract S183).4 The Phase 1b TRiMM-2 study (NCT04108195) evaluated talquetamab in combination with DARZALEX FASPRO® (daratumumab and hyaluronidase-fihj), the CD38-directed monoclonal antibody approved to be given subcutaneously for the treatment of patients with multiple myeloma.4 Results from the study show heavily pretreated patients with multiple myeloma treated with the combination, including talquetamab at the recommended subcutaneous Phase 2 dose (RP2D) administered weekly (QW) or every two weeks (Q2W), achieved high rates of responses, including for patients refractory to anti-CD38 treatment.4
Patients received step-up doses of talquetamab followed by 400 µg/kg QW treatment (n=14) or 800 µg/kg Q2W treatment (n=44), in combination with DARZALEX FASPRO® at the approved dosing schedule.4 With a median follow-up of 5.1 months, the ORR was 80.4 percent (41/51) among all response-evaluable patients.4 Of these patients, 62.7 percent (32/51) achieved a VGPR or better, and 29.4 percent (15/51) achieved a CR or better.4 Among patients with prior exposure to an anti-CD38 antibody, the ORR was 77.3 percent (34/44), and the ORR was 72 percent (18/25) among patients with prior BCMA-targeted treatment.4
No new safety signals were identified with longer follow-up of either dose cohort, and the safety profile for the combination was comparable to each agent as a monotherapy.4 The most common nonhematologic adverse events (AEs) at the 405 µg/kg QW dose were cytokine release syndrome (CRS; 71.4 percent; all Grade 1/2), dysgeusia (71.4 percent; N/A) and dry mouth (71.4 percent; all Grade 1/2).4 The most common AEs at the 800 µg/kg Q2W dose were CRS (77.3 percent; all Grade 1/2), dysgeusia (59.1 percent; N/A), and anemia (43.2 percent; 18.2 percent Grade 3/4). Skin-related and nail disorders were reported in 81 percent of patients.4 Infections were experienced by 53.4 percent of patients (17.2 percent were Grade 3 or higher), and one patient died of pneumonia.4
The primary objectives of the TRiMM-2 study were to identify the recommended Phase 2 dose (RP2D) for each component of the treatment combination (Part 1); characterize the safety of the treatment combination at the RP2D (Part 2); and assess antitumor activity, pharmacokinetics and pharmacodynamics for the combination treatment (Part 3).4 Patients in the study (n=58) had received a minimum three prior lines of therapy or were double refractory to a proteasome inhibitor (PI) and an immunomodulatory agent; patients who had been exposed or refractory to an anti-CD38 therapy more than 90 days prior to the start of the trial were also included, as well as those refractory to anti-CD38 therapy.4
About Talquetamab
Talquetamab is a first-in-class, investigational T-cell redirecting bispecific antibody targeting both GPRC5D, a novel multiple myeloma target that does not shed over time, and CD3, the T-cell receptor.1 CD3 is involved in activating T-cells, and GPRC5D is highly expressed on multiple myeloma cells.5,6 Results from preclinical studies in mouse models demonstrate that talquetamab induces T-cell-mediated killing of GPRC5D-expressing multiple myeloma cells through the recruitment and activation of CD3-positive T-cells and inhibits tumor formation and growth.7
About DARZALEX FASPRO®
In August 2012, Janssen Biotech, Inc. and Genmab A/S entered into a worldwide agreement, which granted Janssen an exclusive license to develop, manufacture and commercialize daratumumab. DARZALEX FASPRO® is the only CD38-directed antibody approved to be given subcutaneously to treat patients with multiple myeloma and now light chain (AL) amyloidosis. DARZALEX FASPRO® is co-formulated with recombinant human hyaluronidase PH20 (rHuPH20), Halozyme's ENHANZE® drug delivery technology.
DARZALEX FASPRO® (daratumumab and hyaluronidase-fihj) is indicated for the treatment of adult patients with multiple myeloma:
- In combination with bortezomib, melphalan, and prednisone in newly diagnosed patients who are ineligible for autologous stem cell transplant
- In combination with lenalidomide and dexamethasone in newly diagnosed patients who are ineligible for autologous stem cell transplant and in patients with relapsed or refractory multiple myeloma who have received at least one prior therapy
- In combination with bortezomib, thalidomide, and dexamethasone in newly diagnosed patients who are eligible for autologous stem cell transplant
- In combination with pomalidomide and dexamethasone in patients who have received at least one prior line of therapy including lenalidomide and a proteasome inhibitor
- In combination with carfilzomib and dexamethasone in patients with relapsed or refractory multiple myeloma who have received one to three prior lines of therapy
- In combination with bortezomib and dexamethasone in patients who have received at least one prior therapy
- As monotherapy in patients who have received at least three prior lines of therapy including a proteasome inhibitor (PI) and an immunomodulatory agent or who are double-refractory to a PI and an immunomodulatory agent
DARZALEX FASPRO® in combination with bortezomib, cyclophosphamide, and dexamethasone is indicated for the treatment of adult patients with newly diagnosed light chain (AL) amyloidosis. This indication is approved under accelerated approval based on response rate. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s).
Limitations of Use
DARZALEX FASPRO® is not indicated and is not recommended for the treatment of patients with light chain (AL) amyloidosis who have NYHA Class IIIB or Class IV cardiac disease or Mayo Stage IIIB outside of controlled clinical trials.
Full prescribing information for DARZALEX FASPRO® is available here.
DARZALEX FASPRO® IMPORTANT SAFETY INFORMATION
CONTRAINDICATIONS
DARZALEX FASPRO® is contraindicated in patients with a history of severe hypersensitivity to daratumumab, hyaluronidase, or any of the components of the formulation.
WARNINGS AND PRECAUTIONS
Hypersensitivity and Other Administration Reactions
Both systemic administration-related reactions, including severe or life-threatening reactions, and local injection-site reactions can occur with DARZALEX FASPRO®. Fatal reactions have been reported with daratumumab-containing products, including DARZALEX FASPRO®.
Systemic Reactions
In a pooled safety population of 898 patients with multiple myeloma (N=705) or light chain (AL) amyloidosis (N=193) who received DARZALEX FASPRO® as monotherapy or in combination, 9% of patients experienced a systemic administration-related reaction (Grade 2: 3.2%, Grade 3: 1%). Systemic administration-related reactions occurred in 8% of patients with the first injection, 0.3% with the second injection, and cumulatively 1% with subsequent injections. The median time to onset was 3.2 hours (range: 4 minutes to 3.5 days). Of the 140 systemic administration-related reactions that occurred in 77 patients, 121 (86%) occurred on the day of DARZALEX FASPRO® administration. Delayed systemic administration-related reactions have occurred in 1% of the patients.
Severe reactions included hypoxia, dyspnea, hypertension, tachycardia, and ocular adverse reactions, including choroidal effusion, acute myopia, and acute angle closure glaucoma. Other signs and symptoms of systemic administration-related reactions may include respiratory symptoms, such as bronchospasm, nasal congestion, cough, throat irritation, allergic rhinitis, and wheezing, as well as anaphylactic reaction, pyrexia, chest pain, pruritus, chills, vomiting, nausea, hypotension, and blurred vision.
Pre-medicate patients with histamine-1 receptor antagonist, acetaminophen, and corticosteroids. Monitor patients for systemic administration-related reactions, especially following the first and second injections. For anaphylactic reaction or life-threatening (Grade 4) administration-related reactions, immediately and permanently discontinue DARZALEX FASPRO®. Consider administering corticosteroids and other medications after the administration of DARZALEX FASPRO® depending on dosing regimen and medical history to minimize the risk of delayed (defined as occurring the day after administration) systemic administration-related reactions.
Ocular adverse reactions, including acute myopia and narrowing of the anterior chamber angle due to ciliochoroidal effusions with potential for increased intraocular pressure or glaucoma, have occurred with daratumumab-containing products. If ocular symptoms occur, interrupt DARZALEX FASPRO® and seek immediate ophthalmologic evaluation prior to restarting DARZALEX FASPRO®.
Local Reactions
In this pooled safety population, injection-site reactions occurred in 8% of patients, including Grade 2 reactions in 0.7%. The most frequent (>1%) injection-site reaction was injection-site erythema. These local reactions occurred a median of 5 minutes (range: 0 minutes to 6.5 days) after starting administration of DARZALEX FASPRO®. Monitor for local reactions and consider symptomatic management.
Cardiac Toxicity in Patients With AL Amyloidosis
Serious or fatal cardiac adverse reactions occurred in patients with AL amyloidosis who received DARZALEX FASPRO® in combination with bortezomib, cyclophosphamide, and dexamethasone. Serious cardiac disorders occurred in 16% of patients, and fatal cardiac disorders occurred in 10% of patients. Patients with NYHA Class IIIA or Mayo Stage IIIA disease may be at greater risk. Patients with NYHA Class IIIB or IV disease were not studied. Monitor patients with cardiac involvement of AL amyloidosis more frequently for cardiac adverse reactions and administer supportive care as appropriate.
Neutropenia
Daratumumab may increase neutropenia induced by background therapy. Monitor complete blood cell counts periodically during treatment according to manufacturer's prescribing information for background therapies. Monitor patients with neutropenia for signs of infection. Consider withholding DARZALEX FASPRO® until recovery of neutrophils. In lower body weight patients receiving DARZALEX FASPRO®, higher rates of Grade 3-4 neutropenia were observed.
Thrombocytopenia
Daratumumab may increase thrombocytopenia induced by background therapy. Monitor complete blood cell counts periodically during treatment according to manufacturer's prescribing information for background therapies. Consider withholding DARZALEX FASPRO® until recovery of platelets.
Embryo-Fetal Toxicity
Based on the mechanism of action, DARZALEX FASPRO® can cause fetal harm when administered to a pregnant woman. DARZALEX FASPRO® may cause depletion of fetal immune cells and decreased bone density. Advise pregnant women of the potential risk to a fetus. Advise females with reproductive potential to use effective contraception during treatment with DARZALEX FASPRO® and for 3 months after the last dose.
The combination of DARZALEX FASPRO® with lenalidomide, thalidomide, or pomalidomide is contraindicated in pregnant women because lenalidomide, thalidomide, and pomalidomide may cause birth defects and death of the unborn child. Refer to the lenalidomide, thalidomide, or pomalidomide prescribing information on use during pregnancy.
Interference With Serological Testing
Daratumumab binds to CD38 on red blood cells (RBCs) and results in a positive indirect antiglobulin test (indirect Coombs test). Daratumumab-mediated positive indirect antiglobulin test may persist for up to 6 months after the last daratumumab administration. Daratumumab bound to RBCs masks detection of antibodies to minor antigens in the patient's serum. The determination of a patient's ABO and Rh blood type are not impacted.
Notify blood transfusion centers of this interference with serological testing and inform blood banks that a patient has received DARZALEX FASPRO®. Type and screen patients prior to starting DARZALEX FASPRO®.
Interference With Determination of Complete Response
Daratumumab is a human immunoglobulin G (IgG) kappa monoclonal antibody that can be detected on both the serum protein electrophoresis (SPE) and immunofixation (IFE) assays used for the clinical monitoring of endogenous M-protein. This interference can impact the determination of complete response and of disease progression in some DARZALEX FASPRO®-treated patients with IgG kappa myeloma protein.
ADVERSE REACTIONS
In multiple myeloma, the most common adverse reaction (≥20%) with DARZALEX FASPRO® monotherapy is upper respiratory tract infection. The most common adverse reactions with combination therapy (≥20% for any combination) include fatigue, nausea, diarrhea, dyspnea, insomnia, headache, pyrexia, cough, muscle spasms, back pain, vomiting, hypertension, upper respiratory tract infection, peripheral sensory neuropathy, constipation, pneumonia, and peripheral edema.
The most common adverse reactions (≥20%) in patients with AL amyloidosis are upper respiratory tract infection, diarrhea, peripheral edema, constipation, fatigue, peripheral sensory neuropathy, nausea, insomnia, dyspnea, and cough.
The most common hematology laboratory abnormalities (≥40%) with DARZALEX FASPRO® are decreased leukocytes, decreased lymphocytes, decreased neutrophils, decreased platelets, and decreased hemoglobin.
Please see full Prescribing Information for DARZALEX FASPRO®.
About Multiple Myeloma
Multiple myeloma is an incurable blood cancer that affects some white blood cells called plasma cells, which are found in the bone marrow.8 When damaged, these plasma cells rapidly spread and replace normal cells in the bone marrow with tumors. In 2020, an estimated 176,000 people worldwide were diagnosed with multiple myeloma.9 In 2022, it is estimated that more than 34,000 people will be diagnosed with multiple myeloma, and more than 12,000 people will die from the disease in the U.S.10 While some people diagnosed with multiple myeloma initially have no symptoms, most patients are diagnosed due to symptoms that can include bone fracture or pain, low red blood cell counts, tiredness, high calcium levels, kidney problems or infections.11
About the Janssen Pharmaceutical Companies of Johnson & Johnson
At Janssen, we're creating a future where disease is a thing of the past. We're the Pharmaceutical Companies of Johnson & Johnson, working tirelessly to make that future a reality for patients everywhere by fighting sickness with science, improving access with ingenuity, and healing hopelessness with heart. We focus on areas of medicine where we can make the biggest difference: Cardiovascular, Metabolism, & Retina; Immunology; Infectious Diseases & Vaccines; Neuroscience; Oncology; and Pulmonary Hypertension.
Learn more at www.janssen.com. Follow us at @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies of Johnson & Johnson.
†Dr. Minnema has served as a consultant to Janssen; she has not been paid for any media work.
*Kyprolis is a registered trademark of Amgen Inc.
Cautions Concerning Forward-Looking Statements
This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995 regarding product development and the potential benefits and treatment impact of teclistamab and DARZALEX FASPRO®. The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Janssen Research & Development, LLC or any of the other Janssen Pharmaceutical Companies and/or Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; manufacturing difficulties and delays; competition, including technological advances, new products and patents attained by competitors; challenges to patents; product efficacy or safety concerns resulting in product recalls or regulatory action; changes in behavior and spending patterns of purchasers of health care products and services; changes to applicable laws and regulations, including global health care reforms; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson's Annual Report on Form 10-K for the fiscal year ended January 2, 2022, including in the sections captioned "Cautionary Note Regarding Forward-Looking Statements" and "Item 1A. Risk Factors," and in Johnson & Johnson's subsequent Quarterly Reports on Form 10-Q and other filings with the Securities and Exchange Commission. Copies of these filings are available online at www.sec.gov, www.jnj.com or on request from Johnson & Johnson. None of the Janssen Pharmaceutical Companies nor Johnson & Johnson undertakes to update any forward-looking statement as a result of new information or future events or developments.
1 Pillarisetti K et al. Blood. 2020;135(15):1232-1243.
2 Minnema M et al. Efficacy and safety of talquetamab, a G protein-coupled receptor family C group 5 member D x CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma (RRMM): updated results from MonumenTAL-1. European Hematology Association 2022 Hybrid Congress. June 2022.
3 Minnema M et al. Efficacy and safety of talquetamab, a G protein-coupled receptor family C group 5 member D x CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma (RRMM): updated results from MonumenTAL-1. American Society of Clinical Oncology 2022 Annual Meeting. June 2022.
4 van de Donk N et al. Novel Combination Immunotherapy for the Treatment of Relapsed/Refractory Multiple Myeloma: Updated Phase 1b Results for Talquetamab (a GPRC5D x CD3 Bispecific Antibody) in Combination With Daratumumab. European Hematology Association 2022 Hybrid Congress. June 2022.
5 Labrijn AF et al. Proc Natl Acad Sci USA. 2013;110:5145.
6 Cohen, Y., et al. Hematology. 2013 Nov; 18(6):348-51.
7 Kumar SK et al. Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group study. Leukemia. 2012 Jan;26(1):149-57.
8 Rajkumar SV. Multiple myeloma: 2020 update on diagnosis, risk-stratification and management. Am J Hematol.2020;95(5):548-5672020;95(5):548-567. http://www.ncbi.nlm.nih.gov/pubmed/32212178
9 Cancer.Net. "Multiple Myeloma: Statistics." Available at:https://www.cancer.net/cancer-types/multiple-myeloma/statistics#:~:text=Worldwide%2C%20an%20estimated%20176%2C404%20people,worldwide%20died%20from%20multiple%20myeloma. Accessed June 3, 2022.
10 American Cancer Society. "Key Statistics About Multiple Myeloma." Available at:https://cancerstatisticscenter.cancer.org/?_ga=2.84250769.967379196.1642100198-1705811479.1642100198#!/. Accessed June 2022.
11 American Cancer Society. "What Is Multiple Myeloma?" Available at: https://www.cancer.org/cancer/multiple-myeloma/about/what-is-multiple-myeloma.html. Accessed June 2022.
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Central Lakes College announced the addition of two new leaders in its Performing Arts Center. Joey Yow has been named Director of the Central Lakes Community Performing Arts Center and Cory Johnson will serve as theatre faculty within the Liberal Arts and Sciences at the college.
“The arts are an integral part of the College. We are proud to serve many audiences and celebrate the impact of performance — through the CLC Performing Arts Center, through our academic programs in both theatre and music and throughout our communities,” said CLC President Dr. Hara Charlier. “We are excited to welcome Joey and Cory to the College. They join incredible teams deeply engaged in this work and will provide strong leadership.”
Charlier said CLC has a deep commitment to the arts, with its rich history in performing arts, visual arts and music.
She notes the college is well known for its work with Brainerd Community Theatre and dramatic arts instruction. It has also expanded its music program with the addition of the Music AFA Degree and eight performance ensembles. With the hiring of Yow and Johnson, the college will continue to expand its program.
Yow most recently served as the managing director of Luna Stage and technical director of Newark Academy in New Jersey. He holds a master’s degree in arts administration. His experience in visual and performing art programming will be a great addition to the CLC community.
Johnson brings a deep background in teaching, acting and directing theatre. She earned her doctorate in theatre at the University of Oregon and has spent the majority of her career at St. Ambrose University in Davenport, Iowa. She has also taught at Augustana College and performed improvisational theatre at Dudley Riggs’ Brave New Workshop in Minneapolis.
Johnson will work closely with Yow and the college to continue moving live theatre forward at CLC.
Combining Johnson’s academic strengths with Yow’s artistic visionary strengths, CLC Foundation Executive Director Kate Adornetto said she is confident that this new leadership will take an already “first-class cultural arts series” to the next level.
“I look forward to working with Joey, Cory and the entire cultural arts community to create even more exciting events for patrons to enjoy,” Adornetto said.
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ALSO READ
Goldman Sachs sees gold prices hitting $2,500/oz by year-end
Gold trading at Rs 49,090 per 10 gm today; silver price at Rs 61,700/kg
Somasundaram PR on how gold demand will pan out in 2022
Gold consumption highest among Indian middle-income group
Dec retail inflation rises to 6-month high of 5.59%; Nov IIP growth at 1.4%
-
By Swati Verma
(Reuters) - Gold prices dipped on Friday, as the dollar firmed ahead of the release of key U.S. inflation data that could drive the Federal Reserve's upcoming policy decisions.
Spot gold fell 0.3% to $1,842.77 per ounce, as of 0954 GMT, and was down about 0.4% for the week. U.S. gold futures declined 0.4% to $1,845.40.
"The U.S. dollar is trading marginally higher, thus weighing on gold prices, but price action will likely remain muted as we head into U.S. CPI later today," said DailyFX analyst Warren Venketas.
"Gold has been consolidating around the key $1,850 zone for some time now, but U.S. inflation data could prompt a breakout."
A higher-than-expected inflation print could bolster the Fed's aggressive stance as the U.S. central bank is expected to increase rates by 50 basis points next week and in July. The consensus forecast sees the year-over-year inflation rate for May steady at a blistering 8.3%.
Major central banks are picking up the pace of interest rate hikes to get on top of surging inflation. A high interest rate environment tends to increase the opportunity cost of holding non-yielding bullion.
"Hawkish central banks, rising real rates and a stronger U.S. dollar have taken the shine off the gold market. Withdrawal of unprecedented fiscal and monetary support is also weighing on sentiment," ANZ Research said in a note.
The current price range of $1,800-$1,900 per ounce will not provide any clear direction until gold breaks either side of the range, ANZ noted.
Meanwhile, gold discounts in India this week were stretched to their highest in seven weeks, while fresh concerns over the spread of COVID-19 in top consumer China left buyers reluctant to make purchases. [GOL/AS]
Elsewhere, silver slipped 0.6% to $21.54 and platinum was down 0.2% at $968.71, while palladium rose 0.1% to $1,927.42. All of them were on course for weekly declines, with platinum set for its worst week since April 22.
(Reporting by Swati Verma in Bengaluru; Editing by Subhranshu Sahu)
(Only the headline and picture of this report may have been reworked by the Business Standard staff; the rest of the content is auto-generated from a syndicated feed.)
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Digital Editor | https://www.business-standard.com/article/markets/gold-investors-cautious-ahead-of-us-inflation-driving-fed-reserve-policy-122061000673_1.html | 2022-06-10T12:53:14Z | https://www.business-standard.com/article/markets/gold-investors-cautious-ahead-of-us-inflation-driving-fed-reserve-policy-122061000673_1.html | false | 1 |
What happened at Muckamore Abbey Hospital outside of Antrim town is the focus of a public investigation that will hear opening statements by core participants on Wednesday and Thursday, the Press Association reports.
It’s been described as the biggest adult safeguarding scandal to affect the National Health Service (NHS) in the UK. It concerns multiple allegations of abuse of vulnerable adults by staff at the state-run hospital.
The public inquiry is running in tandem with an ongoing police criminal investigation that has already resulted in the arrests of 34 suspects and the referral of 38 people for potential prosecution. Eight people are already before the courts on charges of ill-treatment, neglect, and unlawful detention of patients.72 members of staff have been placed on precautionary suspension.
The public inquiry into allegations of abuse at the facility is expected to take several years.
Relatives of patients were among those who attended the opening of inquiry on Monday. They included lead campaigner Glynn Brown, whose son Aaron had been a patient at the hospital.
Brown said he will be watching to see if the “depth and scale” of what happened will be uncovered, and what will be done about it.
It was August 2017 when Brown first learned that his youngest son Aaron, who is non-verbal and suffers from severe learning disabilities, had been assaulted in Muckamore Abbey Hospital. He was shocked to hear from the hospital that the person responsible was a member of staff.
Brown, 61, from Dundonald, told The Irish News that when his son was sent to the hospital several years ago the family was reassured that it was “the best staffed, best trained unit.”
He said, “We didn't want him going in but we thought that if he was in and given the appropriate medication for four to six weeks it'll be worth it.”
Brown said when he asked questions about the assault on his son, he was repeatedly frustrated by the answers he received. He later discovered Aaron had been held in a seclusion room – “an old, dark dungeon with no toilet, no water” – for several hours when patients should have been there for only a few minutes. Aaron had been in it 50 times.
A major police probe has trawled through thousands of hours of footage and Brown said he “lost count at 150 or 160 incidents” police identified on CCTV in relation to Aaron’s case.
Muckamore Abbey is operated by Belfast Health and Social Care Trust.
Speaking ahead of the public hearings, Stormont Health Minister Robin Swann said, “I have no doubt that the inquiry proceedings will be a harrowing experience for all those affected by the abject failure of care at Muckamore. It will also be deeply distressing for everyone who works in health and social care in Northern Ireland.”
Minister Swann has issued a statement in relation to the Muckamore Abbey Hospital Inquiry.
Read the full statement ➡️https://t.co/wQA0N2NbzW pic.twitter.com/HzFrLx9eHI
— Department of Health (@healthdpt) June 6, 2022
*This column first appeared in the June 8 edition of the weekly Irish Voice newspaper, sister publication to IrishCentral. | https://www.irishcentral.com/news/thenorth/muckamore-abbey-northern-ireland-probe | 2022-06-10T12:53:17Z | https://www.irishcentral.com/news/thenorth/muckamore-abbey-northern-ireland-probe | false | 1 |
India has exported 2.47 lakh metric tonnes of alcoholic products, worth USD 322.12 million (approximately Rs 2,507 crore), during 2020-21, the commerce ministry said on Friday.
The major export destinations of Indian alcoholic products include the United Arab Emirates, Ghana, Singapore, Congo, and Cameroon.
It said that the demand of India's products like beer made from malt, wine, white wine, brandy, whisky, rum, and gin has increased manifold in the global market.
The Agricultural and Processed Food Products Export Development Authority (APEDA) has conducted several workshops and wine tasting events at various international trade fairs for creating awareness about the potential of local wines.
Indian wine industry has grown at compound annual growth rate of 14 per cent during 2010 to 2017, making it the fastest growing industry under alcoholic beverage in the country, it added.
In a bid to give a boost to the export of wines, APEDA facilitated participation of ten exporters in London Wine Fair, 2022.
(To receive our E-paper on whatsapp daily, please click here. To receive it on Telegram, please click here. We permit sharing of the paper's PDF on WhatsApp and other social media platforms.) | https://www.freepressjournal.in/business/cheers-india-exports-alcoholic-products-worth-usd-32212-mn-during-2020-21 | 2022-06-10T12:55:44Z | https://www.freepressjournal.in/business/cheers-india-exports-alcoholic-products-worth-usd-32212-mn-during-2020-21 | true | 5 |
Electronic Arts (NASDAQ:EA – Get Rating) was downgraded by Moffett Nathanson from a “buy” rating to a “neutral” rating in a report released on Friday, Briefing.com reports. They currently have a $147.00 price target on the game software company’s stock, up from their previous price target of $141.00. Moffett Nathanson’s target price indicates a potential upside of 8.24% from the stock’s current price.
Other research analysts also recently issued reports about the stock. Robert W. Baird decreased their price target on shares of Electronic Arts from $165.00 to $140.00 in a research report on Wednesday, May 11th. Stifel Nicolaus decreased their price target on shares of Electronic Arts from $165.00 to $155.00 in a research report on Thursday, April 21st. Sanford C. Bernstein began coverage on shares of Electronic Arts in a research note on Friday, April 22nd. They issued an “outperform” rating and a $157.00 price objective for the company. Deutsche Bank Aktiengesellschaft reduced their price objective on shares of Electronic Arts from $170.00 to $165.00 in a research note on Wednesday, May 11th. Finally, StockNews.com raised shares of Electronic Arts from a “hold” rating to a “buy” rating in a research note on Thursday, May 19th. Six equities research analysts have rated the stock with a hold rating and sixteen have assigned a buy rating to the company. According to data from MarketBeat, Electronic Arts presently has a consensus rating of “Buy” and an average price target of $155.29.
NASDAQ:EA opened at $135.81 on Friday. The company’s 50 day moving average price is $127.60 and its 200-day moving average price is $128.84. Electronic Arts has a 52 week low of $109.24 and a 52 week high of $148.93. The company has a quick ratio of 1.18, a current ratio of 1.18 and a debt-to-equity ratio of 0.25. The stock has a market cap of $38.01 billion, a price-to-earnings ratio of 49.21, a PEG ratio of 2.26 and a beta of 0.81.
In related news, CEO Andrew Wilson sold 10,000 shares of the firm’s stock in a transaction that occurred on Tuesday, March 29th. The shares were sold at an average price of $128.58, for a total value of $1,285,800.00. The sale was disclosed in a legal filing with the SEC, which is accessible through the SEC website. Also, insider Chris Bruzzo sold 2,000 shares of the firm’s stock in a transaction that occurred on Wednesday, May 18th. The shares were sold at an average price of $128.39, for a total transaction of $256,780.00. Following the completion of the sale, the insider now directly owns 27,524 shares in the company, valued at approximately $3,533,806.36. The disclosure for this sale can be found here. Insiders have sold 53,638 shares of company stock worth $6,984,354 in the last three months. Corporate insiders own 0.65% of the company’s stock.
Institutional investors have recently made changes to their positions in the business. Equitec Proprietary Markets LLC purchased a new position in Electronic Arts in the fourth quarter valued at approximately $25,000. Tortoise Investment Management LLC increased its stake in Electronic Arts by 294.1% in the first quarter. Tortoise Investment Management LLC now owns 201 shares of the game software company’s stock valued at $25,000 after purchasing an additional 150 shares during the last quarter. Old North State Trust LLC increased its stake in Electronic Arts by 59.2% in the fourth quarter. Old North State Trust LLC now owns 242 shares of the game software company’s stock valued at $32,000 after purchasing an additional 90 shares during the last quarter. Tyler Stone Wealth Management purchased a new position in shares of Electronic Arts during the fourth quarter worth approximately $33,000. Finally, Amplius Wealth Advisors LLC purchased a new position in shares of Electronic Arts during the fourth quarter worth approximately $34,000. Institutional investors own 89.28% of the company’s stock.
About Electronic Arts (Get Rating)
Electronic Arts Inc develops, markets, publishes, and distributes games, content, and services for game consoles, PCs, mobile phones, and tablets worldwide. It develops and publishes games and services across various genres, such as sports, racing, first-person shooter, action, role-playing, and simulation primarily under the Battlefield, The Sims, Apex Legends, Need for Speed, and Plants vs.
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Receive News & Ratings for Electronic Arts Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Electronic Arts and related companies with MarketBeat.com's FREE daily email newsletter. | https://www.etfdailynews.com/2022/06/10/electronic-arts-nasdaqea-cut-to-neutral-at-moffett-nathanson/ | 2022-06-10T12:58:32Z | https://www.etfdailynews.com/2022/06/10/electronic-arts-nasdaqea-cut-to-neutral-at-moffett-nathanson/ | false | 2 |
Cigna Investments Inc. New cut its holdings in shares of Medical Properties Trust, Inc. (NYSE:MPW – Get Rating) by 25.6% in the 4th quarter, according to the company in its most recent filing with the Securities and Exchange Commission (SEC). The fund owned 13,502 shares of the real estate investment trust’s stock after selling 4,650 shares during the quarter. Cigna Investments Inc. New’s holdings in Medical Properties Trust were worth $319,000 at the end of the most recent reporting period.
Other institutional investors have also made changes to their positions in the company. Marshall Wace LLP bought a new position in Medical Properties Trust during the first quarter valued at about $148,000. Morgan Stanley boosted its stake in Medical Properties Trust by 32.9% in the second quarter. Morgan Stanley now owns 4,501,982 shares of the real estate investment trust’s stock valued at $90,489,000 after acquiring an additional 1,115,386 shares during the last quarter. Keudell Morrison Wealth Management grew its position in shares of Medical Properties Trust by 15.8% during the 3rd quarter. Keudell Morrison Wealth Management now owns 73,651 shares of the real estate investment trust’s stock valued at $1,478,000 after acquiring an additional 10,060 shares during the period. Franklin Resources Inc. purchased a new stake in shares of Medical Properties Trust during the 3rd quarter worth approximately $2,034,000. Finally, Neuberger Berman Group LLC raised its holdings in shares of Medical Properties Trust by 245.7% in the 3rd quarter. Neuberger Berman Group LLC now owns 2,017,618 shares of the real estate investment trust’s stock worth $40,473,000 after purchasing an additional 1,434,051 shares during the period. 82.27% of the stock is owned by hedge funds and other institutional investors.
In other Medical Properties Trust news, CFO R Steven Hamner sold 285,000 shares of the business’s stock in a transaction that occurred on Thursday, April 7th. The shares were sold at an average price of $21.04, for a total value of $5,996,400.00. Following the completion of the transaction, the chief financial officer now owns 1,961,214 shares of the company’s stock, valued at approximately $41,263,942.56. The transaction was disclosed in a filing with the SEC, which is available through this link. Also, CEO Edward K. Aldag, Jr. sold 615,000 shares of the stock in a transaction on Wednesday, March 30th. The stock was sold at an average price of $21.33, for a total transaction of $13,117,950.00. The disclosure for this sale can be found here. 1.04% of the stock is currently owned by company insiders.
Shares of Medical Properties Trust stock opened at $16.13 on Friday. The company’s 50-day moving average price is $18.84 and its 200-day moving average price is $20.74. The company has a current ratio of 1.64, a quick ratio of 1.64 and a debt-to-equity ratio of 1.13. Medical Properties Trust, Inc. has a 12-month low of $16.10 and a 12-month high of $24.13. The company has a market cap of $9.68 billion, a price-to-earnings ratio of 8.63, a PEG ratio of 0.92 and a beta of 0.65.
Medical Properties Trust (NYSE:MPW – Get Rating) last posted its earnings results on Thursday, April 28th. The real estate investment trust reported $1.05 earnings per share for the quarter, topping analysts’ consensus estimates of $0.47 by $0.58. Medical Properties Trust had a net margin of 70.61% and a return on equity of 13.25%. The business had revenue of $409.80 million for the quarter, compared to analyst estimates of $413.31 million. During the same quarter in the prior year, the firm posted $0.42 EPS. Medical Properties Trust’s revenue was up 13.0% on a year-over-year basis. On average, sell-side analysts predict that Medical Properties Trust, Inc. will post 1.83 earnings per share for the current year.
The firm also recently disclosed a quarterly dividend, which will be paid on Thursday, July 14th. Investors of record on Thursday, June 16th will be given a $0.29 dividend. The ex-dividend date is Wednesday, June 15th. This represents a $1.16 dividend on an annualized basis and a dividend yield of 7.19%. Medical Properties Trust’s dividend payout ratio (DPR) is presently 62.03%.
About Medical Properties Trust (Get Rating)
Medical Properties Trust, Inc is a self-advised real estate investment trust formed in 2003 to acquire and develop net-leased hospital facilities. From its inception in Birmingham, Alabama, the Company has grown to become one of the world's largest owners of hospitals with 431 facilities and roughly 43,000 licensed beds in nine countries and across four continents on a pro forma basis.
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Receive News & Ratings for Medical Properties Trust Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Medical Properties Trust and related companies with MarketBeat.com's FREE daily email newsletter. | https://www.tickerreport.com/banking-finance/8944974/cigna-investments-inc-new-cuts-stock-position-in-medical-properties-trust-inc-nysempw.html | 2022-06-10T12:59:49Z | https://www.tickerreport.com/banking-finance/8944974/cigna-investments-inc-new-cuts-stock-position-in-medical-properties-trust-inc-nysempw.html | true | 1 |
COLORADO SPRINGS — Drivers in Colorado will start seeing new bicycle safety signs out on the roads, as the Colorado Department of Transportation installs them.
CDOT is working to remind drivers to give bicyclists three feet of space while sharing the roads.
The “Three-Foot Law” requires three feet of space between the widest part of the car and the widest part of the bike.
Drivers are allowed to cross the double yellow line to give that space as long as it does not put oncoming traffic at risk. | https://www.fox21news.com/news/state/cdot-give-bicyclists-3-feet-of-space/ | 2022-06-10T12:59:53Z | https://www.fox21news.com/news/state/cdot-give-bicyclists-3-feet-of-space/ | true | null |
Man of the masses Jr NTR has paved the way to worldwide domination. His latest film 'RRR' has now gone down in history as one of the rarest films to get a re-release in the US, Canada and other locations. This is an unprecedented feat for a film that's already available on streaming platforms.
The massive success of 'RRR' has attracted unanimous appreciation from the biggest stars of Indian cinema, the audience and the critics. Jr NTR is owning the global cinema scene and pulling the audience to the theatres despite his film's availability on OTT.
The first screening of the film happened after a special encorRRRe screening event on June 1 followed by a sold-out show in Los Angeles. Shining in the role of Komaram Bheem, Jr NTR garnered praise for his power-packed performance.
Not the one to rest on his laurels, the actor has launched into his next films including Koratala Siva's NTR30 and Prashanth Neel's NTR31.
(To receive our E-paper on whatsapp daily, please click here. To receive it on Telegram, please click here. We permit sharing of the paper's PDF on WhatsApp and other social media platforms.) | https://www.freepressjournal.in/regional-film-news/footprints-across-the-globe-jr-ntr-treads-boundaries-with-cinema | 2022-06-10T13:00:33Z | https://www.freepressjournal.in/regional-film-news/footprints-across-the-globe-jr-ntr-treads-boundaries-with-cinema | true | 1 |
Urban League to give out gas cards at drive-thru event
Published: Jun. 10, 2022 at 7:03 AM CDT|Updated: 57 minutes ago
ST. LOUIS, Mo. (KMOV) - The Urban League of St. Louis will partner with “Operation Ten City Tour” to provide relief at the pump with gas cards.
The company will host a drive-thru event at the Urban League headquarters on North Kingshighway. The event is set to begin at noon on Saturday and will go until supplies run out. Gas cards, clothing, and free food will be given out on a first-come, first-serve basis.
Copyright 2022 KMOV. All rights reserved. | https://www.kmov.com/2022/06/10/urban-league-give-out-gas-cards-drive-thru-event/ | 2022-06-10T13:01:21Z | https://www.kmov.com/2022/06/10/urban-league-give-out-gas-cards-drive-thru-event/ | true | null |
What Is Monkeypox And Is This Disease a Problem in Michigan?
As we are still dealing with COVID-19, monkeypox has reared its ugly head and now a travel advisory has been issued by the CDC. Obviously, monkeypox is something you do not want to catch but it is a lot harder to catch than COVID-19. Monkeypox is a virus that...
wjimam.com | https://www.newsbreak.com/news/2629389736356/what-is-monkeypox-and-is-this-disease-a-problem-in-michigan | 2022-06-10T13:02:33Z | https://www.newsbreak.com/news/2629389736356/what-is-monkeypox-and-is-this-disease-a-problem-in-michigan | true | null |
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PRISTINA, Kosovo (AP) — German Chancellor Olaf Scholz asked Kosovo and Serbia on Friday for a clear commitment to reaching a lasting political solution to their long-standing dispute over Kosovo's independence.
Normalization talks facilitated by the European Union started 11 years ago but yielded little impact, and tensions between the former opponents in war remain. Scholz, who was in Kosovo to start a multi-nation trip in the Western Balkans, said Russia's war in Ukraine made the region's stability even more important.
“In times like this, the value of peace and security is made clear anew to us, and a further very weighty reason for Kosovo and Serbia to find a political solution with a comprehensive, sustainable solution that also contributes to regional stability,” Scholz at a news conference in Pristina.
The chancellor asked Serbia and Kosovo's governments for a clear commitment to the EU-facilitated dialogue.
“It is clear that an agreement must ultimately also clear up the question of the recognition of Kosovo, because it is not conceivable that two countries that don’t recognize each other become members of the EU,” Scholz said in Pristina, Kosovo's capital.
Kosovo, a former province of Serbia, declared independence in 2008, a decade after a brutal 1998-1999 war between separatist ethnic Albanian rebels and Serb forces. The war ended after a 78-day NATO air campaign that drove Serb troops out and a peacekeeping force moved in.
Most Western nations have recognized Kosovo’s sovereignty, but Serbia and its allies Russia and China do not.
The six Western Balkan countries are at different stages of their EU membership aspirations. Serbia and Montenegro have started full negotiations, while Albania and North Macedonia have faced delays in the EU launching their talks.
Kosovo and Bosnia are in the early stages of the membership.
Kosovar Prime Minister Albin Kurti said the country would apply for EU candidacy status, which Ukraine, Moldova and Georgia have done. Kurt described joining the EU as “the only future.”
Scholz praised Kosovo for supporting EU sanctions against Russia over the invasion of Ukraine, calling the government in Pristina “a reliable partner.”
He also reminded the Serbian government that any country hoping to become an EU member should abide by its laws and customs. Serbia has not joined EU sanctions on Russia and considers Moscow a close ally.
Scholz also plans to visit Serbia, Greece, North Macedonia and Bulgaria on his Balkans trip.
——-
Semini reported from Tirana, Albania; Geir Moulson contributed from Berlin.
___
Follow AP's coverage of the Russia-Ukraine war at https://apnews.com/hub/russia-ukraine
___
Follow Llazar Semini at https://twitter.com/lsemini | https://www.expressnews.com/news/article/Germany-s-Scholz-urges-Kosovo-Serbia-to-commit-17232657.php | 2022-06-10T13:03:51Z | https://www.expressnews.com/news/article/Germany-s-Scholz-urges-Kosovo-Serbia-to-commit-17232657.php | false | 11 |
June 10, 2022
OUR “TRANSITORY,” “HIGH CLASS” PROBLEM IS ACCELERATING AND BEGGARING US: U.S. Inflation Hit 8.6% in May “May’s increase was driven by sharp rises in the prices for energy, which rose 34.6% from a year earlier, and groceries, which jumped 11.9% on the year. Prices for used cars and trucks rose 1.8% in May from April, reversing three months of declines. Shelter costs, an indicator of broad inflation pressures, accelerated on a monthly basis in May and were up 5.5% compared with a year ago.” | https://instapundit.com/525035/ | 2022-06-10T13:04:19Z | https://instapundit.com/525035/ | false | null |
Covid-19 infections have risen for the first time in two months in the UK.
The jump is thought to be caused by the Omicron variant, as in the previous wave.
However, it now comprises the original Omicron variant BA.1 as well as newer variants BA.4 and BA.5, according to the Office for National Statistics (ONS).
A total of 989,800 people in private households are estimated to have had the virus last week, up from 953,900 the previous week.
This is the first time total infections have risen week-on-week since the end of March, when the number hit a record 4.9 million at the peak of the Omicron BA.2 wave.
All four nations have seen a recent rise in infections, though the ONS describes the trend in Scotland and Wales as ‘uncertain’.
In England last week, 797,500 people were likely to test positive for Covid – the equivalent of around one in 70.
This is up week-on-week from 784,100, which was also around one in 70.
In Northern Ireland, around one in 65 people now have the virus, up from one in 75the previous week.
In Scotland, the figure is now one in 40, up from one in 50.
Meanwhile in Wales, the figure is now around one in 75.
The ONS said: ‘Across all four UK countries, the percentage of people testing positive for Covid-19 compatible with Omicron variants BA.1, BA.4 and BA.5 increased in the week ending June 2 2022.’
The original Omicron variant caused a surge in infections across the UK in December and early January.
BA.4 and BA.5 are newer variants that were recently classified by the UK Health Security Agency as ‘variants of concern’, after analysis found both were likely to have a ‘growth advantage’ over BA.2, which is still the dominant strain in the country.
Initial findings suggest BA.4 and BA.5 have a degree of ‘immune escape’ – meaning the immune system can no longer recognise or fight a virus – which is likely to contribute to their growth advantage, the UK Health Security Agency (UKHSA) said.
Meanwhile, separate figures suggested the recent drop in the number of people in hospital with Covid-19 may also have come to a halt.
Some 4,082 patients in England had Covid-19 on June 9, up 6% on the previous week, while in Scotland 637 patients were recorded on June 5 – the latest date available – up 8% week-on-week.
Patient numbers in both nations had previously been on a steady downwards trend since early April, following the peak of the Omicron BA.2 wave.
In Wales and Northern Ireland, the figures for people in hospital with the virus have levelled off in recent days.
Get in touch with our news team by emailing us at webnews@metro.co.uk.
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Not convinced? Find out more » | https://metro.co.uk/2022/06/10/covid-infections-in-the-uk-rise-for-the-first-time-in-two-months-16805298/ | 2022-06-10T13:04:22Z | https://metro.co.uk/2022/06/10/covid-infections-in-the-uk-rise-for-the-first-time-in-two-months-16805298/ | true | 1 |
Britney Spears marries Sam Asghari in California
LOS ANGELES -- Britney Spears has married her longtime partner Sam Asghari at a Southern California ceremony that came months after the pop superstar won her freedom from a court conservatorship.
Asghari's representative Brandon Cohen confirmed the couple's nuptials. He said: "I am very ecstatic this day has come, and they are married. I know he wanted this for so long. He is so caring and supportive every step of the way."
The wedding happened nine months after the pair were engaged and nearly seven months after Spears' conservatorship ended. While seeking an end to the court case that controlled many aspects of her life, Spears expressed her desire to marry Asghari and have children.
Spears got pregnant earlier this year, but experienced a miscarriage in March.
The couple met on the set of the "Slumber Party" music video in 2016.
The wedding day was not without unexpected drama -- Spears' first husband was arrested after attempting to crash their wedding.
Ventura County Sheriff's Capt. Cameron Henderson said officers responded to a trespassing call after 2 p.m. Thursday. He says the pop singer's first husband, Jason Alexander, was detained at the site of the ceremony.
Henderson says Alexander was arrested after officers noticed he had a warrant for his arrest in another county.
Alexander went on his Instagram live when he approached the event security. In what appeared to be a mostly empty but decorated room, he told them Spears invited him.
"She's my first wife, my only wife," said Alexander, who was briefly married to Spears -- his childhood friend -- in 2014. Their marriage lasted only 55 hours.
Spears was previously married to Kevin Federline, with whom she shares two sons, ages 14 and 15. | https://www.dailyherald.com/entlife/20220610/britney-spears-marries-sam-asghari-in-california | 2022-06-10T13:06:03Z | https://www.dailyherald.com/entlife/20220610/britney-spears-marries-sam-asghari-in-california | false | 39 |
Beautifying reality: Two young Romanian artists bring old buildings back to life through their illustrated books
Romanian visual artists Maria Poștea and Bogdan Gărgăriță have turned their passion for painting, illustration and architecture into a business. They publish books in which they "restore" old buildings with special architectural features to look like they did in their golden days. Although they find Romania a difficult country to live in, where artists are not truly appreciated, they have decided to stay so that they can focus on their art and not have to worry about earning their living abroad.
Following an inspiring Erasmus experience abroad during their master’s in 2017, Romanian visual artists Maria Poștea and Bogdan Gărgăriță came up with the idea to open their own publishing house for illustrated books in Bucharest. The couple had no prior experience in managing a business, but they plucked up the courage and dove in, and thus was born the lovingly named “Editura Intaglio”.
Bogdan and Maria both graduated from the Graphic Arts program at the National University of Arts. They later completed their master's degrees specializing in Metal, and Ambient Textile & Design respectively, which expanded their breadth of practical knowledge and enhanced their artistic point of view.
Over the past five years, they’ve published a variety of beautifully illustrated books for both children and adult readers, including two collector’s volumes dedicated to early 20th century Romanian architecture, which are part of their architectural „Detail” series: “The Neo Romanian Detail: Bucharest” and “Secession Detail: Timișoara”. The books offer a unique take on architectural conservation, featuring buildings from the 1900s that were once principal elements in the urban landscape, but which are now pretty much forgotten.
Alongside running the publishing house together, the two of them work on art commissions and teach weekly art classes for children, teens, and adults at their workshop on Negustori Street.
Recently, the couple welcomed me into this very workshop, where we talked about Art Nouveau, passion projects, and what it’s like to open your own business in Romania as an artist.
Maria and Bogdan are both skilled artists and have amassed a portfolio of work that is both plentiful and impressive. Snatches of it are visible here, as the walls of their workshop are covered in vividly painted canvases and highly detailed drawings. They’re beautiful, but I am told they keep their favorites at home.
Tell me about your art. What styles do you work in?
Maria: We're both influenced by the art movements that appeared around the 1900s, such as Art Nouveau. We're great admirers of it, and our illustrations and personal pieces often feature re-interpretations of this movement. Our landscapes are worked in an Impressionist manner. We do Plein air painting, and we try to capture the light of a certain hour and the impression of the moment. We both work figuratively but have experimented with several styles and techniques.
Having worked in various techniques over the years, how did you decide to focus on illustrating and open a publishing house?
Bogdan: The idea came to us in Riga, Latvia, where we studied for a semester during our master’s. We had been doing illustrations for this publishing house in Iași, and there was this guy we were collaborating with there. He told us he was planning on leaving and starting his own publishing house. He suggested we do the same, and we thought sure, why not? We got back to Bucharest in December 2016, and in March 2017 we opened it.
So even though you were studying Metal and Textiles & Design at the time, you were illustrating alongside your studies?
M: Yes, well, while we were in Latvia, we didn’t just do metalwork or textile work. The program was very inclusive, and we were also drawing, painting, printmaking...
B: That’s actually where we first did lithography printmaking. We didn’t have what we needed at school in Romania. Whereas at the university in Riga the materials were available and there were some really skilled teachers, so we learned to print lithographies, and we really went for it. We’d be doing 80 prints in just a few hours.
M: Yeah, we exaggerated a little compared to our classmates. We’d stay on after the end of the class to keep making prints. You know they’re done on the face of a rock, and the design is polished off at the end of the printmaking session so the image is temporary.
B: We wanted to make as many as possible while we could.
It sounds like you did a lot of work while you were there.
M: Absolutely. It was probably the first truly productive period of our lives.
B: We really felt that we were evolving as artists. I remember the first couple of weeks we were there, we were drawing, and we were pretty delighted with what we were creating. Then at the end of our stay, we laid all our drawings side by side to compare them, and we were embarrassed by the first ones we had done. That’s how much we changed in just three months.
M: It was really good for us. I have fond memories of that time. It was a beautiful time in our lives. Riga inspired us in many ways and has remained in our hearts.
B: We definitely want to go back at some point.
Tell me about your publishing house, Intaglio. What does the name stand for?
M: Intaglio is one of the four main types of printmaking, which is done by etching. Our logo represents an etching press, as seen from the side. We both completed graphic design as undergraduates, producing many etchings along the way. In the past, this is how the illustrations in books were duplicated, through various etching techniques. And although we are talking about multiples of the same piece, meaning the resulting works are not unique, etching maintains its collectible nature.
B: That was our goal from the beginning, to create collector’s books.
You have published a selection of niche books that are addressed to adults and are meant to be collector’s items, but you’ve also created several children’s books. What do you like about working for each audience?
B: We both like illustrated children’s books – we regularly buy them for ourselves. And illustrating them is a lot of fun.
M: We started with classic tales such as “Puss in Boots” or “The Town Musicians of Bremen”, but eventually Bogdan started writing his own stories – his newest is “Smaranda the Salamander and the Lakeside Party”.
B: Truthfully, I never thought about writing before this. I feel like laughing at the thought of myself as a writer – but I enjoy it a lot.
M: As for the books meant for adults, I enjoy the challenge. They’re more difficult and take longer to make, we usually work on them for a year or two. And it’s where we’ve had the opportunity to cover a subject that we find very interesting, through the Detail Series.
How did the Detail Series come about? What was your inspiration?
M: It was Riga.
B: Yes, Riga. We are both passionate about the 1900s movement in art, but before Riga, which is actually the city with the highest concentration of Art Nouveau architecture anywhere in the world, we hadn’t focused on the architecture specifically.
M: The Art Nouveau buildings were so beautiful, the facades were so detailed and ornate, it was overwhelming, and they kind of seeped into our consciousness. When we got back we started paying more attention to the buildings in Bucharest, and we realized that we too have beautifully ornamented buildings from that period.
You hadn’t really been aware of them before.
M: No, we hadn’t. And I think they pass unnoticed by most people.
B: That’s one of our goals with this project actually, to introduce people to lesser-known 1900s architecture. Because I think that people are aware of the Art Nouveau buildings in Paris, or Prague, but they don’t know that there is Art Nouveau architecture in Turkey, Cuba, Norway, or here in Romania. Sure, we’d like to document the Art Nouveau hot spots as well, but our biggest wish is to uncover the generally unknown and underrated architecture.
M: And there’s another reason why this project is so important to us. Once we started really looking at our heritage buildings, we realized how beautiful they truly are, but also what a severe state of disrepair they are in. I think that the work of restoring and preserving them is so important. So what we wanted to do is create a catalog, an inventory if you will, of all these buildings built at the turn of the century. We wanted to immortalize them as they were in their golden days before they are altered beyond recognition or they disappear completely. Some of these buildings… I honestly don’t know how long they have left. To see them now as they are is one thing, in person or in photographs, but it’s difficult to visualize what they actually used to look like, and I think there’s real value in seeing them as they used to be.
In your books, these buildings appear in their ideal state, brought to life in vivid watercolor. Would a person be able to recognize them on the street?
M: Some of them are in fairly good condition, so yes. And there are street names and numbers in the accompanying texts, so you can find each building around town. Some of them are quite far from their ideal state, however. They’ve been vandalized, covered in graffiti, the masonry is crumbling, and no one has done any repairs. Some of the buildings belong to people who don’t have enough money to pay for proper restoration.
B: Or in some cases, repairs have been made by owners who have the money, but just don’t care about the original structure. Sometimes you’ll see beautiful turn-of-the-century buildings with mismatched fixtures; ornaments that have absolutely nothing to do with the rest of the building. They take down the original ornaments and put up their own, with no regard for the building’s history.
M: We’ve seen cases where the owner has added a horrendous communist-style balcony smack in the middle of the heritage building. The fact is that many of these historical buildings are not officially considered heritage, so they’re not protected by any laws.
How did you go about “collecting” the buildings for the Detail books? What did your work process look like for each book?
M: For “The Neo Romanian Detail: Bucharest” the process of finding and selecting buildings was done very organically: by bicycle.
B: We would wait for a sunny day, choose a neighborhood, grab our bikes, and go zigzagging up and down each street stopping to take pictures of every 1900s-looking building.
M: After we gathered all the photographs, we took them to Oana Marinache, who is an art historian and researcher. She helped us sort through our findings, organized the material into chapters, and wrote the book’s text. For “Secession Detail: Timișoara”, we collaborated with Mihai Moldovan, who is the manager of the Heritage of Timișoara cultural project. With Mihai, the process was a bit different. He suggested many of the buildings and lead us around the city showing us the buildings and teaching us about them.
So, your books are an educational experience for your readers, but they’ve also been an education for you.
M: Yes, because of them we’ve been introduced to a world that is totally new to us: we’ve entered Mihai’s community of architects, we’ve been invited to see restoration sites, we’ve spoken to the Romanian Order of Architects. We’ve learned a lot.
You started your own business without any prior experience in business or the world of publishing. What has that been like for you?
M: It’s been interesting. We’re not good with paperwork and stuff like that. And there are so many aspects to taking care of the business, that it can be difficult to stay on top of everything sometimes. But we try to handle the administrative side of things the best we can.
B: We do everything. I mean, Intaglio is Maria and me. Our business is deeply personal because we’re passionate about it, but also because it’s built into our lives. Our office headquarters and main workshop are in our apartment. Maria wakes up and starts doing admin over breakfast. We work with an accountant, and we collaborate with outside people, but we do everything else: the illustrations, yes, but also the book design & layout, the administrative tasks, deliveries, managing our social media, and all things marketing. When our books arrive from the printing press, we’re the ones carrying them upstairs to our house, box by box – so we’re the muscle too.
What aspects have you found particularly challenging?
B: I think one of our biggest challenges has been getting to know the ins and outs of publishing itself; learning about typography, page layouts, and dimensions; learning the correct printing terminology. You can’t just create the illustrations and throw them in a book. Everything needs to be carefully thought out, you need to consider things such as How thick is the book’s spine? or How much space needs to be left in the margins so the illustrations aren’t accidentally cut into? We’ve had to learn it all on the go.
M: Through trial and error.
B: And we’re still learning. Every book we create brings its own lessons.
M: Another big challenge has been finding a print house we can work with. We’re a small business and we only need to print 10 to 100 books at a time, but most of them have their minimum amount set at around 500 copies. We can’t afford to print such large quantities.
B: We’ve worked with a few print houses that accept lower quantities, but we’ve encountered various problems. I remember one particular order, it was the biggest we’d made until then. When the order arrived and I took the first book out of its box, the entire inner part fell out, all the pages, and I was left holding the spine. We checked another, and another, and another – same thing. 80% of the books we’d gotten were like that, and we had to send them back. I think it took them several attempts to get them right. It was torturous.
M: We’ve found a print house now, and they’re great, but they’re not in Romania. It would be nice to find someone here at some point.
You’re both Romanian, but you have experience living abroad. How do you feel about building your business here? Is Romania a good country for artists?
M: I think that Romania is a difficult country to live in, in many ways. As artists, I’ve often felt we’d be more appreciated somewhere else. And building a business I’m sure comes with all sorts of hurdles wherever you are, but it seems like there are more than the usual amount here.
Why have you decided to stay here?
M: We’ve stayed here because we’ve built a life here. We have friends, family, a community we belong to, which are very important to us.
B: We love traveling and hope to be able to travel all around the world, but we aren’t really planning on moving somewhere else for good.
M: At least for now.
B: Sometimes I get frustrated with the way things are going here, politically, financially, and ecologically. I sometimes say The Romanian is someone who gasps when they see the sidewalk is level. You know, we’re so used to things going wrong, it’s surprising when they are the way they should be. I feel like it takes a lot of energy to live here, but I haven’t reached that point where I’m like That’s it. Enough. I’m out of here!
M: We hope to see Romania evolve, and are happy whenever we see growth, but we’re not holding our breath. I guess we just try to focus on what we’re doing. And maybe we will end up somewhere else, maybe we’ll stay here. We don’t know yet.
B: I think a benefit of being here is that we can dedicate ourselves to our art. I know people who moved abroad, and they had to work to cover their living expenses, of course, so they ended up getting jobs that had nothing to do with their creative work, and slowly but surely they stopped spending time on their art, they stopped creating. I lived in London for a while, and I had the same problem. I had to work to cover my bills and so I ended up doing all sorts of odd jobs that had nothing to do with visual art. I kept getting orders for pieces back in Romania and I just thought What am I doing here? So, I came back. It’s not ideal here, but as Maria says, we’ve built a life.
How have you been able to fund Intaglio? Do you have any investors?
B: We started our business with pretty much no money to invest in it. Everything we’ve been able to put in has had to come from our regular earnings: our commissioned work, what we make through teaching. In the beginning, every time we’d do a piece on commission, we’d take that money and channel it into the publishing house. In time we were able to supplement that through crowdfunding, and that gave us the opportunity of publishing more complex books.
How do you use crowdfunding in your projects?
M: We’ll start a project, and when we’re close to finishing it, that’s when we launch the crowdfunding campaign. We do it that way so our backers won’t have to wait long before they get the book they paid for. So far we’ve successfully funded four projects.
B: I think crowdfunding is a great tool for artists. It’s really the only way to get projects off the ground if you don’t have large sums of money to invest in them upfront.
M: Unfortunately, here in Romania, it’s not as common as in other places and I think it’s not well understood. People sometimes seem to think of it as a form of begging, which it’s not at all. You’re asking for money, yes, but you’re providing a product in exchange. I hope this mentality changes.
In view of that, I imagine it might be hard to find backers here. Do you use an international crowdfunding platform?
M: We did for part of our first campaign, but it was complicated. Kickstarter isn’t available in Romania and we had to go through someone who lives in a country where it is. We switched to Romanian platforms soon enough: Startarium and Consolid8. The con is that we have access to a much smaller audience through them than we would through an international platform. The pro is that both platforms are run by really nice people. They helped us with each campaign and we’ve had a good experience with both.
As your business grows, what are the next steps you want to take? What plans do you have for the future?
M: On the administrative side of things, it would be nice to add someone to the team. We’d like to find someone to manage our social media and handle marketing. That would free up time which could go into our creative work instead.
B: As for the projects we have planned, I want to do a series of Arthurian legends, which I started with „Tristan and Iseult” and we’re both intent on continuing the Detail series. We’ve already started doing research for the next two books „Secession Detail: Arad” and „Art Nouveau Detail: Bucharest”.
M: We also want to take it to other countries. We’d like to do a book set in Budapest, and one in Riga, for sure.
You seem so busy, I have to ask: when you’re not working on your books, fulfilling orders, or teaching, what are you doing? How do you relax?
M: We paint. (She laughs)
The artwork for the book “Secession Detail: Timișoara” is currently exhibited at the Timișoara Project Center and can be viewed there until June 12. News about the new projects carried out by Editura Intaglio can be found on their website & social media channels.
maia@romania-insider.com
(Photo source: Opening photo by Maia Van Kline, rest of photos courtesy of Maria Poștea and Bogdan Gărgăriță) | https://www.romania-insider.com/interview-romanian-artists-editura-intaglio | 2022-06-10T13:08:17Z | https://www.romania-insider.com/interview-romanian-artists-editura-intaglio | true | 1 |
Astronomers discover mysterious repeating Radio Bursts waves from far away galaxy
In radio astronomy, a fast radio burst (FRB) is a transient radio pulse of length ranging from a fraction of a millisecond to a few milliseconds, caused by some mysterious high-energy astrophysical process that has not yet been discovered. Astronomers estimate the average FRB releases as much energy in a millisecond (one-thousandth of a second) as the Sun puts out in 3 days (which is over 250,000 seconds). | https://www.dnaindia.com/world/video-astronomers-discover-mysterious-repeating-radio-bursts-waves-from-far-away-galaxy-2959488 | 2022-06-10T13:08:51Z | https://www.dnaindia.com/world/video-astronomers-discover-mysterious-repeating-radio-bursts-waves-from-far-away-galaxy-2959488 | false | null |
Washington State secures another recruiting victory in rollercoaster offseason, signs Tennessee transfer guard Justin Powell
A rollercoaster ride of an offseason for Washington State’s basketball program began on bumpy tracks, but the Cougars are cruising smoothly to the finish. One scholarship spot remains open on WSU’s 2022-23 roster after yet another promising addition. The Cougs received a signature Tuesday from Tennessee transfer Justin Powell, a 6-foot-6...
www.khq.com | https://www.newsbreak.com/news/2629526577421/washington-state-secures-another-recruiting-victory-in-rollercoaster-offseason-signs-tennessee-transfer-guard-justin-powell | 2022-06-10T13:09:00Z | https://www.newsbreak.com/news/2629526577421/washington-state-secures-another-recruiting-victory-in-rollercoaster-offseason-signs-tennessee-transfer-guard-justin-powell | true | null |
MADISON, Wis. (AP) — The University of Wisconsin System Board of Regents has approved freezing tuition for in-state undergraduate students again this year.
The Wisconsin State Journal reported that the regents approved the freeze as part of the system’s 2022-23 budget Thursday. System President Jay Rothman said the system would use $25 million in federal COVID-19 pandemic relief funds to support the freeze.
In-state undergraduate tuition has remained flat for the last nine years since Republican legislators imposed a freeze in the 2013-15 state budget.
University officials complained about the freeze routinely for years, saying it hurt their revenue and the state wasn’t providing enough aid to offset the losses. Republican lawmakers voted last year to lift the freeze but regents chose to keep it in place for the 2021-22 academic year.
Rothman has said the freeze will help achieve his core objectives of keeping college affordable, maintaining enrollment and attracting students from underrepresented groups. | https://www.newstimes.com/news/article/UW-regents-extend-undergraduate-tuition-freeze-17232729.php | 2022-06-10T13:10:08Z | https://www.newstimes.com/news/article/UW-regents-extend-undergraduate-tuition-freeze-17232729.php | false | 17 |
Mumbai (Maharashtra) [India], June 10 (ANI/NewsVoir): Two-month-old Sakshi (name changed) had a hole in her heart called the Aorta Pulmonary Window.
With extreme respiratory distress, the child would not have survived infancy if she had not received timely treatment, with financial support from SBI Foundation, through Genesis Foundation. With a weight of 2.9 kilograms, Sakshi is one of the smallest children in India to undergo device closure of Aorta Pulmonary Window.
Also Read | Bhanuka Rajapaksa Recalled to Sri Lanka's ODI Squad for Series Against Australia.
She is the only child of Sahira and Suhail (names changed) from Thane in Maharashtra. A few weeks after her birth, Sakshi had breathlessness and had problems in taking feed. She was diagnosed with a complex congenital heart defect called Aorta Pulmonary Window (AP Window). It occurs in 0.1% of all children born with heart defects.
In a normal heart, there are two main arteries, the aorta and the pulmonary artery, where the aorta carries blood to the body and the pulmonary carries blood to the lungs. In an AP Window, there is a hole between these arteries, which leads to an increased flow of blood to the lungs, thereby increasing the lung pressure. Children with AP Window require immediate intervention, otherwise they do not survive infancy and die due to heart failure.
Dr L Srinivas, the pediatric cardiologist at Jupiter Hospital, Thane did her device closure in the Cath Lab. Her father is a labourer (loader) earning a very humble salary. With no money for treatment, her surgery was funded by SBI Foundation in coordination with Genesis Foundation.
At two months with a weight of 2.9 kilograms, Sahira is one of the 25+ children that SBI Foundation is supporting in partnership with Genesis Foundation. In most of the cases where children are born with simple heart defects, one-time medical intervention ensures that they are treated for life and can lead a normal life.
"We are proud of how the medical infrastructure and capacity in our country is advancing, that such complex treatment procedures can be performed on infants. Through our partnership with Genesis Foundation and Jupiter Hospital, we are happy we could provide timely financial support for Sahira's treatment and we look forward for her bright future," - Lalit Mohan, President & COO, SBI Foundation.
"It is only through support of CSR partners like SBI Foundation that we are able to Save Little Hearts, one child at a time. Their belief in the transparency of our work, ensures that children like Sahira who would not have survived even their infancy, are able to live a healthy and fulfilling life," - Simran Sagar, Operations Director, Genesis Foundation.
"I am extremely thankful to Genesis Foundation and SBI Foundation for the timely financial help that was provided to the family because without it, Sahira would not have survived. With one medical intervention done at the right time, she can lead a normal life now," - Dr L Srinivas, Pediatric Cardiologist, Jupiter Hospital, Pune.
SBI Foundation is the CSR arm of the State Bank of India. True to its tradition of service beyond banking, the foundation currently works in over 28 states and union territories of India, on rural development, healthcare, education, livelihood and skill development, youth empowerment, promotion of sports, and more. SBI Foundation believes in reflecting the ethos of the SBI group, in running interventions that are ethical, promote growth and equality, and create a positive impact on the society. www.sbifoundation.in
Genesis Foundation facilitates medical treatment for critically ill under-privileged children suffering with Congenital Heart Defects. The support required in the said critical illness varies from specific surgeries (including neonatal), Cath Lab Interventions along with recovery and recuperation post-surgery.
We, Save Little Hearts.
So far, we have supported medical treatment of over 3600 critically ill children. The children supported by the Foundation belong to families with an income of less than or equal to Rs. 20,000 per month, whose parents are unable to afford treatment for their children.
GF is registered under Section 12-A and 80-G of the Income Tax Act, which entitles 50% tax exemption. GF is also registered under FCRA allowing it to receive foreign funds.
This story is provided by NewsVoir. ANI will not be responsible in any way for the content of this article. (ANI/NewsVoir)
(This is an unedited and auto-generated story from Syndicated News feed, LatestLY Staff may not have modified or edited the content body) | https://www.latestly.com/agency-news/business-news-genesis-foundation-and-sbi-foundation-together-save-a-2-month-old-baby-from-heart-failure-3810498.html | 2022-06-10T13:11:29Z | https://www.latestly.com/agency-news/business-news-genesis-foundation-and-sbi-foundation-together-save-a-2-month-old-baby-from-heart-failure-3810498.html | true | 1 |
Request unsuccessful. Incapsula incident ID: 8080000370162471613-674865600409897294 | https://www.bizjournals.com/southflorida/news/2022/06/10/pmg-closes-on-brickell-development-site-for-58m.html | 2022-06-10T13:11:50Z | https://www.bizjournals.com/southflorida/news/2022/06/10/pmg-closes-on-brickell-development-site-for-58m.html | false | null |
Mumbai (Maharashtra) [India], June 10 (ANI): The wait is finally over! The much-anticipated trailer of Aditya Roy Kapur-starrer 'Om: The Batlle Within' was unveiled on Friday and it's no less than a feast for the eyes.
The trailer begins with Prachi Shah crying about losing one son in a fire, and the other facing a memory loss. Then we see Jackie Shroff as a nuclear scientist expressing the importance of a nuclear test. Unfortunately, he gets arrested for allegedly betraying the country. Ashutosh Rana then marks his entry and introduces protagonist Aditya Roy Kapur's character with a voice-over, "This mission can be completed by only one warrior, and his name is Om. Aditya then enters and unleashes his action avatar.
However, while fighting enemies, he ends up losing his memory. We are then told that he is the son of Jackie. The trailer ends with him promising himself to protect his father's honour and the nation's pride.
"Rakth rahe ya na rahe rashtra humesha rahega," Aditya concluded the trailer by delivering this dialogue in his intense voice.
Also Read | Deepika Padukone Visits Tirupati With Father Prakash Padukone on His Birthday (View Pics).
Aditya's ripped muscles and action-packed avatar have left the audience in awe of his look.
"Oh My God! He is looking killer," a social media user commented.
"Amazing transformation. Can't take my eyes off Aditya, " another one wrote.
"Whistle-worthy performance," a netizen commented.
Helmed by Kapil Verma, 'Om: The Battle Within' also features Sanjana Sanghi, Ashutosh Rana, and Prakash Raj. Bank-rolled by Zee Studios and Ahmed Khan, the film will hit cinema halls on July 1. (ANI)
(This is an unedited and auto-generated story from Syndicated News feed, LatestLY Staff may not have modified or edited the content body) | https://www.latestly.com/agency-news/entertainment-news-aditya-roy-kapur-unleashes-his-action-avatar-in-om-the-battle-within-3810662.html | 2022-06-10T13:12:10Z | https://www.latestly.com/agency-news/entertainment-news-aditya-roy-kapur-unleashes-his-action-avatar-in-om-the-battle-within-3810662.html | false | 2 |
There have been multiple attacks against Pensacola's homeless. How the community can help.
Crime is a fact of any community, whether it be a small township or a large city.
But can crime be reduced, particularly in a vulnerable group like the homeless community?
Michael Kimberl, director of the Alfred Washburn Center, thinks so.
"If we address their basic concerns, we wouldn't see the crime," he said.
There have been multiple killings and acts of violence in Pensacola's homeless community this year, including a recent incident in which a dog was hit with a machete while protecting its owner from an attacker.
According to Kimberl, he and his organization encounter many homeless people in the Pensacola community who have a "don't ask, don't tell" philosophy when it comes to the violence he sees perpetrated against one another.
Helping Hands:Whether saving lives or raising morale, these Escambia citizens make world a better place
Ways to help:Pensacola's homeless population needs friends and mentors. Here's how you can help.
The Alfred Washburn Center is designed to accomplish what Kimberl believes is the stepping stone to people getting out of homelessness.
The Center is a volunteer ministry run through the Society of St. Vincent de Paul to serve the homeless and poor members of the community, and it offers showers, laundry facilities, food and can provide identification cards, according to Kimberl.
An example of the crime Kimberl seeks to eliminate within the homeless community occurred May 5 when Cory Pinkerton, registered in Escambia County Jail as homeless, allegedly attacked a homeless woman behind a Dunkin' Donuts with a machete.
"(Victim) stated that the white male pulled out a machete and started swinging it around in the air and coming toward her," Pinkerton's police report noted.
While swinging the machete, the victim's dog jumped between the attacker and victim and Pinkerton struck the dog multiple times in the head before running away, according to the police report.
The health of the dog is unknown, but the report mentions that animal control would not provide treatment without payment.
Pinkerton was arrested May 31 and charged with felony aggravated assault and felony animal cruelty. As of Thursday he was in Escambia County Jail on $50,000 bond.
"I see so much violence perpetrated against each other," Kimberl said. "They're always sleeping with one eye open.
“The past decade Pensacola is showing us what doing nothing looks like,” he added. "We're seeing punitive measures don't fix issues."
A brutal attack:Pensacola man charged with allegedly beating homeless man to death with tree branch
Another tragedy:Pensacola police: Two homeless men charged with brutally beating man with metal pipe
There have been multiple instances of homicide, violence and preventable deaths within the local homeless population within the last year alone.
In March, two homeless men allegedly beat another with a metal pipe, causing multiple skull fractures for the victim and a stint in the intensive care unit.
In January, three men were attacked in a camp near Palafox and Jordan streets. One man was killed and two others were hospitalized after a man allegedly beat them with a tree branch.
In another tragic incident in January, a woman suffered fatal burns when a portable heater in her tent caused a fire.
Some preventative education services provided by the city include fire safety training and education that Escambia County Emergency Management (ECEM) and Escambia Fire Rescue set up to educate the homeless community.
More from Escambia Fire Rescue:Escambia fire services have a budget shortfall. That may mean higher taxes for us all.
According to ECEM Manager Travis Tompkins, homeless people often start fires to keep warm, which causes tents or even other people to catch fire, endangering those nearby.
"It's unfortunately really common," Tompkins said. "We're trying to go over an education campaign."
Part of the education campaign included distributing flyers on June 3 to local community centers and known homeless camps while teaching basic fire safety.
"We try to make sure we provide fire education, particularly to those who live outside," said Davis Wood, ECEM public information and education officer. "We want to make sure we can get to them and keep them safe."
While these services are meant to help and can provide education, Kimberl said he believes it's not enough.
His idea of keeping the homeless community "out of survival mode" is to increase the number of low-barrier shelters in and around Pensacola.
Kimberl said that the definition of a low-barrier shelter varies from person to person, but it essentially means there are few or even no entry requirements to the shelter.
The thought behind this type of shelter is that it removes the need for homeless individuals to worry about basic necessities or meeting shelter criteria, giving individuals the opportunity to focus on upward mobility.
"We need nonprofits to step up and open a low-barrier shelter," Kimberl said, "allow them to come as long as you behave."
The problem, he says, is the cost of infrastructure to build a low-barrier shelter with essential amenities may be too high, but he says that does not stop him from advocating for a shelter that could provide the homeless with basic needs, giving them an opportunity to focus on the future. | https://www.pnj.com/story/news/crime/2022/06/10/fixing-homelessness-pensacola-may-start-prioritizing-basic-needs/7502356001/ | 2022-06-10T13:16:28Z | https://www.pnj.com/story/news/crime/2022/06/10/fixing-homelessness-pensacola-may-start-prioritizing-basic-needs/7502356001/ | true | 1 |
The all-oral, once-daily combination regimen also demonstrates the potential of immune restoration in this patient population
VIENNA, June 10, 2022 /PRNewswire/ -- The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new and updated results from the Phase 2 CAPTIVATE study evaluating IMBRUVICA® (ibrutinib) in combination with venetoclax (I+V) as a potential fixed-duration (FD) treatment in adult patients with previously untreated chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). Updated data from the FD cohort with three years of follow-up shows that I+V continues to demonstrate deep and durable responses and clinically meaningful progression-free survival (PFS) and overall survival (OS) in the first-line treatment setting. New data will be presented from the minimal residual disease (MRD) cohort, which suggests immune restoration with this combination. These data will be presented during the 2022 European Hematology Association (EHA) Annual Congress taking place in Vienna, Austria June 9-12 (Abstracts #S144 and #P669).
"These promising data highlight the complementary mechanism of action between ibrutinib and venetoclax in a fixed-duration combination regimen," said Carol Moreno, M.D., Ph.D., Consultant Hematologist, Hospital de la Santa Creu Sant Pau, Autonomous University of Barcelona, Barcelona, Spain, and study investigator.† "The CAPTIVATE study suggests that this combination may have the potential to provide treatment-free remissions for patients and effectively eradicate CLL cells and help to restore normal B cells to healthy donor levels in patients with previously untreated CLL/SLL."
The Phase 2 CAPTIVATE (PCYC-1142) study (NCT02910583) – sponsored by Pharmacyclics LLC, an AbbVie Company, and Janssen Biotech, Inc. – enrolled 323 patients with previously untreated CLL/SLL who were younger than 70 years, including patients with high-risk disease, in two cohorts: an FD cohort where all patients stopped therapy after 12 cycles of the combination, regardless of MRD status; and an MRD-guided cohort where treatment duration was guided by the patients' MRD status after 12 cycles of I+V combination (patients who met criteria for confirmed undetectable minimal residual disease [uMRD] were randomized 1:1 to placebo or IMBRUVICA®; patients who did not meet uMRD criteria were randomized to IMBRUVICA® or I+V).1,2
Three-Year Follow-Up Data from the FD Cohort of the Phase 2 CAPTIVATE (PCYC-1142) Study of IMBRUVICA®-Based Combination Regimen in Previously Untreated Patients with CLL/SLL (Abstract #P669)1
After an additional year of follow-up data from the FD cohort of CAPTIVATE, I+V continues to demonstrate deep, durable responses and clinically meaningful PFS, including in patients with del(17p)/TP53 mutated or unmutated immunoglobulin heavy chain gene (IGHV).1 The clinical data underscore the distinct and complementary modes of action of IMBRUVICA® and venetoclax (a BCL-2 inhibitor).1 IMBRUVICA® has been shown to mobilize CLL cells out of lymph nodes and other lymphoid niches and into peripheral blood where they are more susceptible to venetoclax-induced apoptosis, eliminating dividing and resting CLL cells.1
Key findings from the Phase 2 CAPTIVATE FD cohort study include:
- At a median follow-up of 38.7 months, the 36-month PFS rate was 88 percent for all treated patients, 80 percent for patients with del(17p)/TP53 mutated and 86 percent for unmutated IGHV patients (95 percent Confidence Interval [CI]).1
- With an additional year of follow-up, no additional OS events occurred. The 36-month OS rate was 98 percent, overall (95 percent CI).1
- The complete response (CR) rate was 57 percent (n=159; 95 percent CI, 50-65) and consistent across high-risk subgroups.1
- Median duration of CR was not reached (n=91); the 24-month landmark estimate for duration of CR was 94 percent. Median duration of response was not reached for responding patients (n=153).1
- Seventy-nine percent of patients (n=125) achieved undetectable uMRD at any time in the peripheral blood (PB) and/or bone marrow.1
- Of patients with uMRD in PB at three months posttreatment, 78 percent (66/85) of evaluable patients maintained uMRD through 12 months posttreatment.1
- All patients are currently off treatment.1 Frequently occurring treatment-emergent adverse events (TEAEs) (period from first dose until 30 days after the last dose of study treatment) were primarily Grade 1/2 in severity with the exception of neutropenia.1 Median time to onset of frequently occurring TEAEs generally occurred within four months (87-100 percent).1 The median time to resolution or improvement ranged from 16.5 days (diarrhea) to 42.5 days (arthralgia).1 No new serious adverse events or secondary malignancies have been reported since the primary analysis.1
- Twelve patients who progressed after FD treatment with I+V have been retreated with single-agent IMBRUVICA®; 11 of the 12 patients were evaluable for response, with 10 responding.1
New Data from the MRD-Guided Cohort of the Phase 2 CAPTIVATE (PCYC-1142) Study of IMBRUVICA®-Based Combination Regimen Evaluating Immune Restoration in Previously Untreated Patients with CLL/SLL (Abstract #S144)2
Data on the changes over time in the cellular immune profile in patients with CLL/SLL treated with the I+V combination and age-matched healthy donors were featured in an oral presentation at EHA. The FD regimen of I+V in the confirmed uMRD placebo arm effectively eradicated CLL cells to healthy donor levels and enabled sustained regeneration of normal B cell counts.2
Immune restoration was evaluated in 79 previously untreated patients with CLL/SLL enrolled in the MRD cohort by monitoring changes over time in the cellular immune profile of patients treated with I+V combination regimen and compared to 20 age-matched healthy donors.2
Key findings from this analysis include:
- Patients with confirmed uMRD (n=40) had a significantly more pronounced decrease in circulating CLL cell count than patients with uMRD not confirmed (n=39).2
- From Cycle 16 – 29, patients with Confirmed uMRD (n=40) had cell counts similar to those of healthy donors (≤0.8 cell/μL).2
- Normalization of critical immune cells, including T-cell subsets, classical monocytes, and dendritic cell counts was observed in this population.2
"These new clinical and immune results from the CAPTIVATE study add further evidence of the promise of IMBRUVICA in a fixed-duration regimen for previously untreated CLL patients," said Craig Tendler, M.D., Vice President, Late Development and Global Medical Affairs, Janssen Research & Development, LLC. "IMBRUVICA has become a standard of care in CLL treatment, and we continue to explore novel combinations such as I+V which may offer the option of off-treatment, disease-free intervals for patients with B-cell malignancies."
The CAPTIVATE study is part of a comprehensive development program exploring the potential of IMBRUVICA®-based FD therapy. Janssen continues to evaluate the I+V combination regimen and its potential to provide a FD treatment option for patients living with CLL/SLL. Recently, The New England Journal of Medicine Evidence published the primary analysis from the Phase 3 GLOW study, which evaluated the safety and efficacy of the I+V combination in older or unfit patients with CLL/SLL, and showed that the combination demonstrated superior PFS and deeper sustained responses compared to chemoimmunotherapy in first-line CLL.3
About IMBRUVICA®
IMBRUVICA® (ibrutinib) is a once-daily oral medication that is jointly developed and commercialized by Janssen Biotech, Inc. and Pharmacyclics LLC, an AbbVie company. IMBRUVICA® blocks the Bruton's tyrosine kinase (BTK) protein, which is needed by normal and abnormal B cells, including specific cancer cells, to multiply and spread. By blocking BTK, IMBRUVICA® may help move abnormal B cells out of their nourishing environments and inhibits their proliferation.4,5,6
IMBRUVICA® is approved in more than 100 countries and has been used to treat more than 250,000 patients worldwide. There are more than 50 company-sponsored clinical trials, including 18 Phase 3 studies, over 11 years evaluating the efficacy and safety of IMBRUVICA®.
IMBRUVICA® was first approved by the U.S. Food and Drug Administration (FDA) in November 2013, and today is indicated for adult patients in six disease areas, including five hematologic cancers. These include indications to treat adults with CLL/SLL with or without 17p deletion (del17p), and adults with Waldenström's macroglobulinemia (WM), and adult patients with previously treated mantle cell lymphoma (MCL)*, as well as to treat adult patients with previously treated marginal zone lymphoma (MZL) who require systemic therapy and have received at least one prior anti-CD20-based therapy*, and adult patients with previously treated chronic graft-versus-host disease (cGVHD) after failure of one or more lines of systemic therapy.7
*Accelerated approval was granted for MCL and MZL based on overall response rate. Continued approval for MCL and MZL may be contingent upon verification and description of clinical benefit in confirmatory trials.
Since 2019, the National Comprehensive Cancer Network® (NCCN®), recommends ibrutinib (IMBRUVICA®) as a preferred regimen for the initial treatment of CLL/SLL and has Category 1 treatment status for treatment-naïve patients without deletion 17p/TP53 mutation and as a preferred treatment for treatment-naïve patients with deletion 17p/TP53 mutation. The NCCN Guidelines® also recommend IMBRUVICA®, with or without rituximab, as a preferred regimen for the treatment of relapsed/refractory MCL, as a Category 1 preferred regimen for both untreated and previously treated WM patients, and as a preferred regimen for relapsed/refractory MZL.8
For more information, visit www.IMBRUVICA.com.
IMBRUVICA® IMPORTANT SAFETY INFORMATION
WARNINGS AND PRECAUTIONS
Hemorrhage: Fatal bleeding events have occurred in patients who received IMBRUVICA®. Major hemorrhage (≥ Grade 3, serious, or any central nervous system events; e.g., intracranial hemorrhage [including subdural hematoma], gastrointestinal bleeding, hematuria, and post procedural hemorrhage) occurred in 4.2% of patients, with fatalities occurring in 0.4% of 2,838 patients who received IMBRUVICA® in 27 clinical trials. Bleeding events of any grade including bruising and petechiae occurred in 39%, and excluding bruising and petechiae occurred in 23% of patients who received IMBRUVICA®, respectively.
The mechanism for the bleeding events is not well understood.
Use of either anticoagulant or antiplatelet agents concomitantly with IMBRUVICA® increases the risk of major hemorrhage. Across clinical trials, 3.1% of 2,838 patients who received IMBRUVICA® without antiplatelet or anticoagulant therapy experienced major hemorrhage. The addition of antiplatelet therapy with or without anticoagulant therapy increased this percentage to 4.4%, and the addition of anticoagulant therapy with or without antiplatelet therapy increased this percentage to 6.1%. Consider the risks and benefits of anticoagulant or antiplatelet therapy when co-administered with IMBRUVICA®. Monitor for signs and symptoms of bleeding.
Consider the benefit-risk of withholding IMBRUVICA® for at least 3 to 7 days pre- and post-surgery depending upon the type of surgery and the risk of bleeding.
Infections: Fatal and non-fatal infections (including bacterial, viral, or fungal) have occurred with IMBRUVICA® therapy. Grade 3 or greater infections occurred in 21% of 1,476 patients who received IMBRUVICA® in clinical trials. Cases of progressive multifocal leukoencephalopathy (PML) and Pneumocystis jirovecii pneumonia (PJP) have occurred in patients treated with IMBRUVICA®. Consider prophylaxis according to standard of care in patients who are at increased risk for opportunistic infections. Monitor and evaluate patients for fever and infections and treat appropriately.
Cardiac Arrhythmias, Cardiac Failure and Sudden Death: Fatal and serious cardiac arrhythmias and cardiac failure have occurred with IMBRUVICA®. Deaths due to cardiac causes or sudden deaths occurred in 1% of 4,896 patients who received IMBRUVICA® in clinical trials, including in patients who received IMBRUVICA® in unapproved monotherapy or combination regimens. These adverse reactions occurred in patients with and without preexisting hypertension or cardiac comorbidities. Patients with cardiac comorbidities may be at greater risk of these events.
Grade 3 or greater ventricular tachyarrhythmias were reported in 0.2%, Grade 3 or greater atrial fibrillation and atrial flutter were reported in 3.7%, and Grade 3 or greater cardiac failure was reported in 1.3% of 4,896 patients who received IMBRUVICA® in clinical trials, including in patients who received IMBRUVICA® in unapproved monotherapy or combination regimens. These events have occurred particularly in patients with cardiac risk factors including hypertension and diabetes mellitus, a previous history of cardiac arrhythmias, and in patients with acute infections.
Evaluate cardiac history and function at baseline, and monitor patients for cardiac arrhythmias and cardiac function. Obtain further evaluation (e.g., ECG, echocardiogram) as indicated for patients who develop symptoms of arrhythmia (e.g., palpitations, lightheadedness, syncope, chest pain), new onset dyspnea, or other cardiovascular concerns. Manage cardiac arrhythmias and cardiac failure appropriately, follow dose modification guidelines, and consider the risks and benefits of continued IMBRUVICA® treatment.
Hypertension: Hypertension occurred in 19% of 1,476 patients who received IMBRUVICA® in clinical trials. Grade 3 or greater hypertension occurred in 8% of patients. Based on data from 1,124 of these patients, the median time to onset was 5.9 months (range, 0.03 to 24 months). Monitor blood pressure in patients treated with IMBRUVICA®, initiate or adjust anti-hypertensive medication throughout treatment with IMBRUVICA® as appropriate, and follow dosage modification guidelines for Grade 3 or higher hypertension.
Cytopenias: In 645 patients with B-cell malignancies who received IMBRUVICA® as a single agent, grade 3 or 4 neutropenia occurred in 23% of patients, grade 3 or 4 thrombocytopenia in 8% and grade 3 or 4 anemia in 2.8%, based on laboratory measurements. Monitor complete blood counts monthly.
Second Primary Malignancies: Other malignancies (10%), including non-skin carcinomas (3.9%), occurred among the 1,476 patients who received IMBRUVICA® in clinical trials. The most frequent second primary malignancy was non-melanoma skin cancer (6%).
Tumor Lysis Syndrome: Tumor lysis syndrome has been infrequently reported with IMBRUVICA®. Assess the baseline risk (e.g., high tumor burden) and take appropriate precautions. Monitor patients closely and treat as appropriate.
Embryo-Fetal Toxicity: Based on findings in animals, IMBRUVICA® can cause fetal harm when administered to a pregnant woman. Advise pregnant women of the potential risk to a fetus. Advise females of reproductive potential to use effective contraception during treatment with IMBRUVICA® and for 1 month after the last dose. Advise males with female partners of reproductive potential to use effective contraception during the same time period.
ADVERSE REACTIONS
B-cell malignancies: The most common adverse reactions (≥30%) in patients with B-cell malignancies (MCL, CLL/SLL, WM and MZL) were thrombocytopenia (54.5%)*, diarrhea (43.8%), fatigue (39.1%), musculoskeletal pain (38.8%), neutropenia (38.6%)*, rash (35.8%), anemia (35.0%)*, and bruising (32.0%).
The most common Grade ≥ 3 adverse reactions (≥5%) in patients with B-cell malignancies (MCL, CLL/SLL, WM and MZL) were neutropenia (20.7%)*, thrombocytopenia (13.6%)*, pneumonia (8.2%), and hypertension (8.0%).
Approximately 9% (CLL/SLL), 14% (MCL), 14% (WM) and 10% (MZL) of patients had a dose reduction due to adverse reactions. Approximately 4-10% (CLL/SLL), 9% (MCL), and 7% (WM [5%] and MZL [13%]) of patients discontinued due to adverse reactions.
cGVHD: The most common adverse reactions (≥20%) in patients with cGVHD were fatigue (57%), bruising (40%), diarrhea (36%), thrombocytopenia (33%)*, muscle spasms (29%), stomatitis (29%), nausea (26%), hemorrhage (26%), anemia (24%)*, and pneumonia (21%).
The most common Grade 3 or higher adverse reactions (≥5%) reported in patients with cGVHD were pneumonia (14%), fatigue (12%), diarrhea (10%), neutropenia (10%)*, sepsis (10%), hypokalemia (7%), headache (5%), musculoskeletal pain (5%), and pyrexia (5%).
Twenty-four percent of patients receiving IMBRUVICA® in the cGVHD trial discontinued treatment due to adverse reactions. Adverse reactions leading to dose reduction occurred in 26% of patients.
*Treatment-emergent decreases (all grades) were based on laboratory measurements.
DRUG INTERACTIONS
CYP3A Inhibitors: Co-administration of IMBRUVICA® with strong or moderate CYP3A inhibitors may increase ibrutinib plasma concentrations. Increased ibrutinib concentrations may increase the risk of drug-related toxicity. Dose modifications of IMBRUVICA® are recommended when used concomitantly with posaconazole, voriconazole, and moderate CYP3A inhibitors. Avoid concomitant use of other strong CYP3A inhibitors. Interrupt IMBRUVICA® if strong inhibitors are used short-term (e.g., for ≤ 7 days). Avoid grapefruit and Seville oranges during IMBRUVICA® treatment, as these contain strong or moderate inhibitors of CYP3A. See dose modification guidelines in USPI sections 2.3 and 7.1.
CYP3A Inducers: Avoid coadministration with strong CYP3A inducers.
SPECIFIC POPULATIONS
Hepatic Impairment (based on Child-Pugh criteria): Avoid use of IMBRUVICA® in patients with severe hepatic impairment. In patients with mild or moderate impairment, reduce recommended IMBRUVICA® dose and monitor more frequently for adverse reactions of IMBRUVICA®.
Please click here to see the full Prescribing Information.
About the Janssen Pharmaceutical Companies of Johnson & Johnson
At Janssen, we're creating a future where disease is a thing of the past. We're the Pharmaceutical Companies of Johnson & Johnson, working tirelessly to make that future a reality for patients everywhere by fighting sickness with science, improving access with ingenuity, and healing hopelessness with heart. We focus on areas of medicine where we can make the biggest difference: Cardiovascular, Metabolism, & Retina; Immunology; Infectious Diseases & Vaccines; Neuroscience; Oncology; and Pulmonary Hypertension.
Learn more at www.janssen.com. Follow us at @JanssenGlobal and @JanssenUS. Janssen Research & Development, LLC and Janssen Biotech, Inc. are part of the Janssen Pharmaceutical Companies of Johnson & Johnson.
†Dr. Moreno has served as a paid consultant to Janssen; she has not been paid for any media work.
Cautions Concerning Forward-Looking Statements
This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995 regarding product development and the potential benefits and treatment impact of IMBRUVICA® (ibrutinib). The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Janssen Research & Development, LLC or any of the other Janssen Pharmaceutical Companies and/or Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; manufacturing difficulties and delays; competition, including technological advances, new products and patents attained by competitors; challenges to patents; product efficacy or safety concerns resulting in product recalls or regulatory action; changes in behavior and spending patterns of purchasers of health care products and services; changes to applicable laws and regulations, including global health care reforms; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson's Annual Report on Form 10-K for the fiscal year ended January 2, 2022, including in the sections captioned "Cautionary Note Regarding Forward-Looking Statements" and "Item 1A. Risk Factors," and in Johnson & Johnson's subsequent Quarterly Reports on Form 10-Q and other filings with the Securities and Exchange Commission. Copies of these filings are available online at www.sec.gov, www.jnj.com or on request from Johnson & Johnson. None of the Janssen Pharmaceutical Companies nor Johnson & Johnson undertakes to update any forward-looking statement as a result of new information or future events or developments.
1 Moreno C., et al. Fixed-Duration Ibrutinib + Venetoclax for First-Line Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: 3-Year Follow-Up From the FD Cohort of the Phase 2 CAPTIVATE Study. 2022 European Hematology Association Annual Congress. June 9-12, 2022.
2 Soloman I., et al. Immune Restoration and Synergistic Activity With First-Line Ibrutinib Plus Venetoclax: Translational Analyses of CAPTIVATE Patients with CLL. 2022 European Hematology Association Annual Congress. June 9-12, 2022.
3 Kater, A., et al. Fixed-Duration Ibrutinib-Venetoclax in Patients with Chronic Lymphocytic Leukemia and Comorbidities. NEJM Evidence. 2022. Accessed June 2022 https://doi.org/10.1056/evidoa2200006
4 Genetics Home Reference. Isolated growth hormone deficiency. http://ghr.nlm.nih.gov/condition/isolated-growth-hormone-deficiency. Accessed June 2022.
5 Turetsky A, et al. Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor. Scientific Reports. 2014;6:4782.
6 de Rooij MF, Kuil A, Geest CR, et al. The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia. Blood. 2012;119(11):2590-2594.
7 IMBRUVICA® U.S. Prescribing Information, May 2022.
8 NCCN® Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma V2.2022. National Comprehensive Cancer Network. Accessed June 2022.
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SOURCE Janssen Oncology | https://www.walb.com/prnewswire/2022/06/10/new-imbruvica-ibrutinib-data-fixed-duration-combination-regimen-presented-eha-2022-shows-deep-durable-response-three-years-untreated-chronic-lymphocytic-leukemia/ | 2022-06-10T13:16:42Z | https://www.walb.com/prnewswire/2022/06/10/new-imbruvica-ibrutinib-data-fixed-duration-combination-regimen-presented-eha-2022-shows-deep-durable-response-three-years-untreated-chronic-lymphocytic-leukemia/ | false | 13 |
Why do school vacations in Italy last three months?
School is out! Parents have almost 14 consecutive weeks in front of them to manage their children.
School ends, along comes summer and the search for camps for children and teens, some 5 million of them, who will return to their desks at the start of the new school year, set for September 12-19 next year.
That's nearly 14 weeks parents must cover. An undertaking that comes at a high cost: according to the National Association for Consumer Defense and Guidance, the average weekly expense for a private camp is 170 euros, and only 25 percent of families can afford it.
The long summer break is also a time when students experience regression: according to the American Educational Research Association, more than 51 percent of children experience "summer learning loss," meaning they lose between 17 and 28 percent of knowledge in the humanities and between 25 and 34 percent in math.
According to the Eurydice network, the number of school days in fact varies, from 156 days in Albania and 200 days in Denmark and Italy.
Italy, however, not only has more school days, it also has the longest vacations: they range on average from a minimum of 6 to 8 consecutive weeks (France, Germany, UK, Norway, for example) to 10 to 12 weeks (Finland, Greece, Iceland, Portugal, Spain, Hungary), to 13 weeks in Italy and Latvia.
In Italy, the biggest break is in summer, while many countries break up the year with more frequent short breaks (in addition to Christmas and Easter, there is also an autumn and spring break).
But why does Italy, despite many proposals, continue with this school calendar with the longest break in Europe? It is a choice with roots more than a century old, when, in order to allow even farmers' children to be able to attend school, the calendar followed the wheat cycle, which is harvested in July.
Since the year 2000 several governments have tried to "shorten" the school summer vacation, without success.
In 2008, Francesco Rutelli and Giuseppe Fioroni, then minister of education, had timidly suggested aligning with other countries and going down to 12 weeks. But nothing was done about it.
In 2013, the Monti government tried to move from three to one month of vacation, but the school calendar reform was shelved.
In 2015, Labor Minister Giuliano Poletti proposed shortening the vacations and devoting a month to education- a proposal that fell on deaf ears.
Why? Skeptics usually repeat that it is a decision that takes into account the climate factor: going to school until the end of June, or from September 1, would especially penalize students in the South, who face higher temperatures than students in the North.
In 2021, current Prime Minister Mario Draghi had put forward the idea of a longer year to allow kids affected by the pandemic and distance learning to recover, and "summer schools" were activated, which will return this year.
Education Minister Patrizio Bianch explained, "The summer plan was a great success last year... This year there are about 290 million resources available... And we will make this experience structural. For many years there was talk about schools opening in the summer. We said we would open them, and we did."
However, as many parents point out, summer school has been dictated by the availability of individual schools, principals and teachers.
An integrated structural initiative would be needed to change the Italian school calendar. But, for now, all is silent.
To the parents of Italy, in bocca al lupo.
Photo credit: MZeta / Shutterstock.com | https://www.wantedinrome.com/news/why-do-school-vacations-in-italy-last-three-months.html | 2022-06-10T13:18:03Z | https://www.wantedinrome.com/news/why-do-school-vacations-in-italy-last-three-months.html | false | 1 |
A mob of young bicycle bandits allegedly "rampaged" through Shellharbour TK Maxx on Thursday night, just a day after a shoplifting crackdown.
A witness who caught the alleged looting on video said the group targeted the store's designer stock, loading up with 20 to 30 items each before allegedly fleeing the store on bikes.
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"It would have been thousands of dollars [worth]," the woman, who did not wish to be identified, told The Mercury.
The woman was browsing at TK Maxx with her one-year-old baby on Thursday when she saw the group come in just before 7PM.
She said they were a group of around six boys who looked to be in their teens, and one adult in his 30s.
"They were rampaging through the store - they didn't care about anyone," she said.
After snapping photos of the teens allegedly piling baskets with designer clothes, the woman left the store.
Suspecting that the group was up to no good, she started recording the entrance of TK Maxx from the carpark and caught the group as they allegedly fled the scene on bicycles.
"I just couldn't believe what was going on," she said.
"There were a fair few people in the store - they clearly just didn't care."
The woman said TK Maxx had no security, so the only thing staff could do was watch the chaos unfold.
"There was no security, no one could have intervened," she said.
"They nearly bowled over a woman."
After speaking with staff, the woman said the alleged looting was not a one-off, but rather something that was happening weekly.
"I dare say they need security," she said.
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Police conducted a search of the surrounding area; however, those involved were not found, and staff told police the alleged thieves got away with several items.
Read more: NSW govt splash cash in lead-up to budget
Police officers are urging anyone with information to contact Lake Illawarra Police Station
The alleged looting comes just one day after Wollongong Police conducted a shoplifting blitz in the CBD, cracking down on people stealing from stores in the shopping centre.
Police charged 23 people during the shoplifting sting, including a woman accused of stealing a $500 jacket and another who allegedly nicked over $200 in groceries.
Officers from the Wollongong Police District's proactive crime team conducted the operation on Wednesday, issuing 14 court attendance notices and seven criminal infringement notices.
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Police say similar operations are expected in the future.
After several shoplifters targeted grocery stores, a spokesperson from Coles told The Mercury there are trained covert security officers in stores nationally.
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Illawarra Mercury trainee journalist and newest recruit.
Illawarra Mercury trainee journalist and newest recruit. | https://www.illawarramercury.com.au/story/7775090/scared-shoppers-watched-chaos-unfold-inside-tk-maxx-shellharbour/ | 2022-06-10T13:22:28Z | https://www.illawarramercury.com.au/story/7775090/scared-shoppers-watched-chaos-unfold-inside-tk-maxx-shellharbour/ | false | 1 |
Geico facing payout to woman claiming she got an STD after sex in car
Published: Jun. 10, 2022 at 9:09 AM EDT|Updated: 12 minutes ago
KANSAS CITY, Mo. (AP) — Geico may have to pay $5.2 million to a woman who says she contracted a disease during sex in a car with a man insured by the company.
A Missouri Court of Appeals panel on Tuesday upheld the award to a woman identified in court records as M.O.
She alleged a man she was in a relationship with did not tell her before they had sex in his car that he had HPV, the human papillomavirus.
The Maryland-based insurance company argued in its appeal that it had not been given due process and the arbitration agreement was unenforceable.
Geico has filed a separate federal lawsuit contending the man’s insurance policy doesn’t cover the claim.
Copyright 2022 The Associated Press. All rights reserved. | https://www.wvlt.tv/2022/06/10/geico-facing-payout-woman-claiming-she-got-an-std-after-sex-car/ | 2022-06-10T13:23:48Z | https://www.wvlt.tv/2022/06/10/geico-facing-payout-woman-claiming-she-got-an-std-after-sex-car/ | true | 19 |
Compliance certification strengthens Cribl’s role in cybersecurity use cases and expands its footprint in the enterprise
SAN FRANCISCO, June 1, 2022 /PRNewswire/ -- Cribl, the leader in enabling open observability, today announced the completion of its Service Organization Control 2 (SOC 2) Type II security compliance attestation. SOC 2 ensures compliance with worldwide industry standards for data security and enables enterprises to be confident in using Cribl in their observability and cybersecurity environments. This announcement builds on Cribl's momentum, following its recent $150 million Series D funding round and announcement of its newest product, Cribl Search.
Today's cybersecurity landscape is increasingly complex and the range of tools in use generate an unprecedented amount of data. Cribl's approach to open observability allows cybersecurity teams to easily ingest, enrich, and redact data from across their security toolsets, ensuring teams never miss critical signals in a sea of noisy, high volume data.
SOC 2 standards are established by the American Institute of Certified Public Accountants (AICPA) and address security controls such as organization and management, monitoring of controls, communications, risk management, and more. The Type II evaluation means brand manufacturers using Cribl Suite to collect, enrich, distribute, and search their observability and cybersecurity data can feel confident in the secure design and operating effectiveness of the Cribl Suite, having gone through a rigorous security verification process.
"From advanced, persistent threats to remote work and ransomware, the stakes for cybersecurity leaders have never been greater," said Clint Sharp, CEO and Co-Founder of Cribl. "Our users are finding that converging observability and cybersecurity practices and tools give them improved detection capabilities, more control over their security data, and better operational efficiencies."
Cybersecurity teams are already relying on observability practices and tooling to gain new insights. According to ESG's "Observability from Code to Cloud" survey, 41 percent of respondents are using observability tooling to improve their security posture and help with vulnerability detection and impact analysis. Fifty-two percent of respondents found observability solutions improved their ability to detect security-related signals in observability data.
Many of the industry's leading cybersecurity providers are also realizing how cybersecurity and observability can combine to enable greater protection across enterprise systems. The integration of an observability layer into an organization's security practice provides a full grasp of potential business risk, and allows teams to interrogate security data wherever it lives, which is critical to effectively combating threats in an ever-changing security landscape.
"Time is mission-critical in securing an organization's most valuable asset – its data," said Daniel Bernard, Chief Marketing Officer at SentinelOne. "With Singularity XDR, we've converged EPP and EDR, taking our platform beyond the traditional endpoint. Observability is the next link in the chain to transforming cybersecurity in the era of XDR, minimizing the time between detection and response."
To learn more about Cribl's leading observability architecture, visit booth 5469 at the 2022 RSA Conference in San Francisco. After the show on Tuesday, join Cribl and SentinelOne for a special concert at Metreon City View. Cribl will also be at Gartner's Security and Risk Summit in National Harbor at booth 1158.
Cribl makes open observability a reality for today's tech professionals. The Cribl product suite defies data gravity with radical levels of choice and control. Wherever the data comes from, wherever it needs to go, Cribl delivers the freedom and flexibility to make choices, not compromises. It's enterprise software that doesn't suck, enables tech professionals to do what they need to do, and gives them the ability to say "Yes." With Cribl, companies have the power to control their data, get more out of existing investments, and shape the observability future. Founded in 2017, Cribl is a remote-first company with an office in San Francisco, CA. For more information, visit www.cribl.io or our LinkedIn, Twitter, or Slack community.
Cribl Media Contact Kelly Engemoen media@cribl.io
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SOURCE Cribl | https://www.wvlt.tv/prnewswire/2022/06/01/cribl-achieves-soc-2-certification-further-unifies-cybersecurity-observability/ | 2022-06-10T13:24:00Z | https://www.wvlt.tv/prnewswire/2022/06/01/cribl-achieves-soc-2-certification-further-unifies-cybersecurity-observability/ | true | 12 |
WOODLAND HILLS, Calif. , June 10, 2022 /PRNewswire/ -- As part of Neoss' milestone celebration delegates at the Neoss Integrate 2022 congress in Gothenburg, Sweden were given the first access to the NeoScan 1000 intraoral scanner which is set for full commercial launch in September 2022.
"I am excited to introduce the NeoScan 1000 into our range of intuitive dental solutions. The performance of the scanner is beyond my expectations with clear competitive advantages. The scanner will allow Neoss' to significantly expand its proprietary digital dental offering."
Dr. Robert Gottlander, CEO and President of Neoss Group.
Designed for scanning accuracy and speed, the compact, lightweight scanner provides the possibility for a flexible workflow with open and compatible output at a competitive price.
"The NeoScan 1000 is a superfast, lightweight, and easy-to-use scanner. I had the pleasure of being part of early testing and have used the scanner for several digital impression indications at my clinic with excellent results. Digital dentistry is in need of more cost-efficient solutions so that clinicians can use it to its full potential. The NeoScan 1000 has the potential to do just this."
Dr. Marcus Dagnelid, DDS, board-certified prosthodontist
With an easy USB cable connection and full-touch screen support, the NeoScan 1000 is sure to please and excite dental professionals alike! For more information visit neoss.com/neoscan1000
Neoss offers intelligent solutions that are intuitively easy to use. Our products allow dental professionals to provide reliable and cost-effective treatments to their patients with predictable long-term results. Leading the market with ingenuity and integrity, we strive to set new standards. In developing smart treatment solutions and working closely with each practice, Neoss makes the complex less complicated. We call that Intelligent Simplicity. Headquartered in Harrogate, UK, with research and development based in Gothenburg, Sweden, the company has established a global footprint with a long-standing presence in key markets. To find out more visit https://www.neoss.com
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SOURCE Neoss | https://www.wdtv.com/prnewswire/2022/06/10/neoss-group-releases-neoscan-1000-mark-20-years-intelligent-simplicity/ | 2022-06-10T13:26:42Z | https://www.wdtv.com/prnewswire/2022/06/10/neoss-group-releases-neoscan-1000-mark-20-years-intelligent-simplicity/ | true | 10 |
Two new Virginia laws will create health insurance options for two groups of businesses that have felt shut out of more affordable coverage.
One allows associations to set up a benefits consortium that would help small businesses gain the same buying muscle that large employers have for employee health insurance.
“It’s about access to health care, something I’ve worked on my entire career, and affordability,” said state Sen. Monty Mason, D-Williamsburg, who sponsored the measure.
He said the law would help small businesses — those with between 2 and 50 employees — attract and retain workforce by offering health coverage to workers and their families,
The other new law allows the Virginia Association of Realtors to arrange for group insurance for its members.
“It’s a way to make health insurance more affordable,” said Del. Keith Hodges, R-Urbanna, who sponsored the Realtors’ group insurance bill.
Both proposals have been battlegrounds for years, opposed out of concern that they’d take enough people out of the Affordable Care Act health insurance marketplace to push up premiums for everyone else.
The idea with the benefits consortium bill, as pitched to the General Assembly, is that it would allow groups like the Virginia Chamber of Commerce to set up a mechanism that lets small businesses access the relatively low premiums that large employers can command.
Mason said the idea was that consortium would pool tens of thousands of employees of small businesses; by spreading risks over such a large number, the cost per-person is less. The consortium would be run by a board of directors. Any surplus of revenue over claims and required reserves would be used to hold down future premiums.
Mason said he began working on the proposal — his first effort came in 2020 — not long after he gave a talk to a Chamber panel saying he thought the idea was a bad one.
“They asked if we could talk about it, and after they explained what it could do, I said ‘if you decide to go ahead, let me know and I’ll carry it,’” Mason said.
“We intend to form a benefits consortium,” said Laura Ramthun, the chamber’s director of communications and marketing.
The chamber is waiting for the state Bureau of Insurance to write regulations, she said.
Basically, the law says associations would be able to set up something like the self-insured pool that many major employers use, and make its coverage available to small businesses. With self-insurance, instead of buying a policy and counting on an insurer’s financial resources to cover claims, an employer puts up its own funds, usually hiring a company to run the program.
The consortium’s coverage would have to include all the health benefits required in the Affordable Care Act, as well as the cost-sharing and value of coverage standards in that act. It would be barred from denying coverage for pre-existing conditions.
Like workers’ compensation insurance, it would set a base rate for participating companies, and once the companies’ actual experience with claims is none, their specific premiums would be pegged at set percentages above, at or below the base rates, while trends for the entire pool would determine future base rates.
The Realtor’s bill takes a different approach, providing a way for individual members to buy insurance policies with rates like those that groups are quoted, rather than individual market premiums, said Martin Johnson, the association’s senior vice president for government relations.
For some, their income is high enough that they can’t take advantage of the Affordable Care Act’s subsidies. For others who may not be doing as well or who are just starting a career, even with the subsidies, the premiums can feel hard to afford.
“Realtors aren’t like other professionals: they’re independent contractors for the most part. So they can only get insurance in the individual market,” Hodges said.
He said two key points helped him make the case for the bill: the first, that some 20% of Realtors don’t have insurance, so his bill would bring the number of uninsured Virginians down by several thousand.
The second key point was that the bill says any plan the Realtors eventually arrange would have to include at least all the essential benefits required in Affordable Care Act plans.
Daywatch
That mattered because past efforts for alternative health coverage, such as extending periods for short term coverage, faltered when health plans and other opponents said their narrower set of benefits would woo too many healthy people away from ACA plans’ pools. The result would be a spiral of premium increases.
What the bill allows is for the association to shop for a group insurance policy for them — basically for the same kind of group coverage that larger businesses now buy if they don’t opt for a self-insurance program, Johnson said.
The association is talking to insurers and the Bureau of Insurance to see how this could work; whether it goes ahead will depend on the kind of rates it is quoted, Johnson said.
For Realtors who get their insurance through the ACA individual market, but who try to stretch their dollars by not buying as much coverage as they might need, his bill would provide an option to address their insufficient coverage, Hodges said.
After the intense debates before General Assembly committees over the past several years, “there is not much controversy left over it having an adverse impact,” said Doug Gray, executive director of the Virginia Association of Health Plans.
The final version of the benefit consortium bill passed the state Senate 40-0 and the House by 63-35. The Realtors bill passed the House 95-2 and the Senate 40-0.
Dave Ress, 757-247-4535, dress@dailypress.com | https://www.dailypress.com/government/virginia/dp-nw-mewa-20220610-p3j4swyzlbbj3jxwpiky7p65ui-story.html | 2022-06-10T13:27:12Z | https://www.dailypress.com/government/virginia/dp-nw-mewa-20220610-p3j4swyzlbbj3jxwpiky7p65ui-story.html | false | 3 |
EODY announces 4,493 new Covid-19 cases, 17 deaths
Greece’s National Organization for Public Health (EODY) on Friday said it has recorded 4,493 new cases of Covid-19 and 17 deaths in the last 24 hours.
A total of 3,492,268 people have been officially infected with the virus since the start of the pandemic while the death toll has risen to 29,997.
There were also 110 intubated patients in hospitals on Friday, EODY said. | https://www.ekathimerini.com/news/1186562/eody-announces-4493-new-covid-19-cases-17-deaths/ | 2022-06-10T13:28:51Z | https://www.ekathimerini.com/news/1186562/eody-announces-4493-new-covid-19-cases-17-deaths/ | true | null |
Security experts have found a way to track people using the Bluetooth chips integrated into their mobile devices, and laptops, but it’s a lot harder than it sounds (and not quite effective, yet).
Researchers at the University of California, San Diego, have discovered that each individual Bluetooth chip has a tiny imperfection, created during the manufacturing process. In a sense, despite the fact that they’re being produced at scale, and have measures in place to prevent identification, all of these chips are somewhat unique.
That uniqueness, the researchers have found, can be tracked.
Fingerprinting the devices
However, to track the chip, the potential attacker would first need to identify the device, or “capture” its unique “fingerprint”, in order to identify that tiny imperfection. After that, they need a radio receiver capable of recording raw radio signals. Apparently, this can be done with off-the-shelf gear costing no more than $150.
Furthermore, they would need to be relatively close to the victim to be able to snoop on the Bluetooth’s transmissions. To make things even more complicated - not all chips have the same capacity, and range.
"They will know when the target device is near the receiver when it captures one or more packets that matches the target's physical layer fingerprint," the researchers say.
"The more frequently the BLE device transmits, the more likely the attacker is to receive a transmission if a user passes by. Also, the more accurate the fingerprinting technique is, the better the attacker can differentiate the target from other nearby devices."
While the concept might work when there’s only a handful of devices around, it gets a bit more tricky in crowded environments. Testing the flaw on 162 devices, the researchers were able to identify 40% of Bluetooth chips, while testing on 647 mobile devices, the percentage went up to almost half (47%).
"By evaluating the practicality of this attack in the field, particularly in busy settings such as coffee shops, we found that certain devices have unique fingerprints, and therefore are particularly vulnerable to tracking attacks. Others have common fingerprints – they will often be misidentified," the researchers concluded. | https://www.techradar.com/nz/news/you-can-now-add-bluetooth-to-the-list-of-privacy-threats-to-be-worried-about | 2022-06-10T13:29:02Z | https://www.techradar.com/nz/news/you-can-now-add-bluetooth-to-the-list-of-privacy-threats-to-be-worried-about | false | 6 |
LONDON, June 10, 2022 /PRNewswire/ -- Grundig and Beko, leading household appliance companies, participated in Europe's major kitchen trade show, EuroCucina 2022, to showcase their latest product innovations and share insights from Arçelik CEO, Hakan Bulgurlu and Grundig Brand Ambassador, Chef Massimo Bottura.
Speaking at the Sustainability Talks, Hakan Bulgurlu and Massimo Bottura discussed the current state of the climate, food social sustainability and how failure to act on climate change now may drive a global food crisis that transcends economies and regions. Their discussion also turned to how companies should place sustainability at the heart of their business strategy, drawing examples of projects that Arçelik is pursuing to achieve its ambitious vision.
Commenting on the growing climate crisis, Hakan stated that "the amount of time left, to avoid an increase of 1.5°C in temperature, is incredibly small and the current state of the planet is, unfortunately, dire." Arguing that pursuing a sustainable business model is urgent, achievable and ultimately rewarding for companies, which is why Arçelik is deeply committed to reaching net zero by 2050.
The discussion also examined the impact of climate change on food security worldwide. Hakan stated that "the rising heat has already damaged agricultural capacity in many countries, which forces governments to limit or even ban exports of various crops. This creates a food shortage and leads to more and more people going to bed hungry, each night." To combat this crisis, Grundig partnered with Chef Bottura, who founded the Food for Soul Initiative in early 2016 to encourage communities to fight food waste in the interest of social inclusion as well as individual wellbeing. This project created the foundation of the relationship between Chef Bottura and Grundig.
Chef Bottura states that, "Grundig is the only foreign company to which I am very closed both for a sharing of values and for gratitude because they were among the first to believe in my Food for Soul project. We both want to change things simply, connecting people can really make the difference to change the world. If you want to change something you have to stay together."
Grundig, as the official partner of Food for Soul, has set up more than thirteen refettorios, around the world. Refettorios aim to develop community spaces and experiences that promote sustainability and help tackle food waste. So far, these efforts have helped save more than 955 tonnes of food saved, distributed 2.08 million hospitality meals, and engaged over a 100,000 chefs and volunteers.
In talking about solutions, Hakan spoke about Arçelik's decarbonisation roadmap and ambitious plans to offset carbon emissions, which led to the topic of energy efficiency. Arçelik's decarbonisation vision is led by the company's effort to ensure energy efficiency in both the production and the products. As home appliances are such a necessity, the responsibility to reduce the large amount of energy consumed by these appliances, falls on their producers. With that in mind, Arçelik aims to increase its products' energy efficiency by 50% by 2030.
The talks appropriately took place in Beko and Grundig's 'Zero-Impact' booth, which was designed by architect, Martino Berghinz and named, 'Sustainability on Stage'. The materials used to create the booth were, altogether more than ninety five percent reusable. Additionally, to highlight the guests' overall sustainability experience, Beko and Grundig partnered with ZeroCO2, a company specialising in reforestation projects with high social impact, to carry out an in-depth Life Cycle Assessment (LCA) analysis of Beko and Grundig's participation in the event, and a subsequent offsetting operation. This operation involves a social fruit-planting project that will not only offset the CO2 emitted, but also support local farming families by donating the planted fruit to contribute to their economic and food well-being.
The booth also featured Beko's Beyond and Grundig's Prologue Ranges as well as two Immersive Rooms, dedicated to telling a story of those technologies that are most representative of Arçelik's commitment to sustainability. These rooms offered visitors, a virtual and multisensory experience. The products and their associated technologies included within both of these ranges demonstrates Arçelik's efforts towards creating a manufacturing ecosystem that favours the circular economy. For example,
- Grundig's FiberCatcher Washing Machines integrates the first-of-its-kind filter that collects and retains 90 percent of the microfibres produced by washing cycles, which would otherwise pollute the marine ecosystem, and consequently end up in the food we eat.
- Beko's HarvestFresh Refrigerators, are designed to better preserve the vitamin and nutritional contents of fruits and vegetables.
In its entirety Beko and Grundig's zero-impact booth offered guests a holistic sustainability experience, while reaffirming Arçelik's commitments to innovation in the service of the more sustainable future.
ARCELIK
With over 40,000 employees throughout the world, Arçelik's global operations including sales and marketing offices in 51 countries, and 28 production facilities in 9 countries with 12 brands (Arçelik, Beko, Grundig, Blomberg, ElektraBregenz, Arctic, Leisure, Flavel, Defy, Altus, Dawlance, Voltas Beko). As Europe's second-largest white goods company by market share (based on volumes), Arçelik reached a consolidated turnover of 6.5 billion Euros in 2021. Arçelik's 29 R&D and Design Centers & Offices across the globe, are home to over 2,000 researchers and hold more than 3,000 international patent applications to date. In 2021, Arçelik achieved the highest score in the DHP Household Durables category for the 3rd year in a row in the Dow Jones Sustainability Index of the S&P Global Corporate Sustainability Assessment. Through its leadership position in sustainability and credible decarbonization roadmap for achieving net zero, Arçelik became the first and only company from its industry to receive the Terra Carta Seal by HRH Prince of Wales. Arçelik's mission is 'Respecting the World, Respected Worldwide.'
GRUNDIG
Grundig is the international home appliance brand of Arçelik, which is a multinational household appliances manufacturer that operates with 12 brands and employs over 40,000 people worldwide. Grundig is one of the world's leading providers of products in the areas of entertainment electronics, small electrical appliances, and major home appliances. The brand remains true to its brand attributes including its extensive experience in the market for 76 years, user-friendly and elegant design, eco-consciousness, high standards, and quality control.
Grundig believes that a sustainable future starts at home. To support this vision, Grundig adopts the 'Respect Food' initiative aiming to inspire everyone to fight food waste by showing how to tackle waste in kitchens and with innovative products. Grundig fulfills its responsibility for sustainable business practice and makes an important contribution to its parent company, Arçelik's 2030 sustainability targets with its sustainable partnerships and communication, energy-efficient product development, and innovation approach focusing on circular economy, and other sustainability pillars. At the same time, Grundig further empowers its customers to achieve more sustainable living.
BEKO
Beko is the international home appliance brand of Arçelik, which is a multinational household appliances manufacturer that operates with 12 brands and employs over 40,000 people worldwide. Beko is one of the top 3 large home appliances brands in Europe*. The brand is FC Barcelona's main partner, naming partner of Fenerbahçe Men's Basketball Team and official supplier of European League of Legends Championship (LEC).
Beko has been focusing on healthy living for years, raising awareness and developing products that make healthy living possible and convenient. Beko's brand mission is 'healthy living is only possible on a healthy planet'. Beko is committed to protecting the planet by designing and manufacturing energy-efficient products and investing in resource efficiency in production.
*Source Euromonitor International Limited; Large Appliances as per "Major Appliances" in Consumer Appliances 2022ed, retail volume, 2021 data.
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LOS ANGELES, June 10, 2022 /PRNewswire/ -- Docupace, the leader in cloud-based fintech digital operations software for the wealth management industry, announced today that company chief executive officer David Knoch will be presenting at the RBC Capital Markets 2022 Financial Technology Conference to be held in New York City on June 14, 2022.
Knoch will join Addepar President David Obrand and Greg Beltzer, Head of Technology at RBC Wealth Management, for session "Transforming RBC Wealth Management Through Technology" – a compelling conversation on RBC Wealth Management's transformative journey toward delivering a truly "next generation" experience to clients, financial advisors and affiliates.
Additional speakers and presenters at the event include top-level executives from Betterment, Envestnet, Mastercard, PayPal, SS&C, Visa and many more leaders of the fintech/wealthtech industry.
Docupace is a solutions provider focused on digitizing and automating operations in the financial advice and investment industry. Financial services firms use the Docupace Platform (a cloud-based, integrated software suite) to reduce back-office expenses, improve efficiency, strengthen recruiting, and enhance the experience of advisors and investors. With headquarters in Los Angeles, California, Docupace is proud to serve some of the largest independent broker-dealers and registered investment advisers (RIAs) in the financial services industry. The company won the 2021 Gold Globee® Award for "Hot Technology of the Year" and was named to 2021 Inc. 5000 list of the nation's fastest-growing private companies. For more information, please visit www.docupace.com.
Docupace Media Contact:
Ryan George
Chief Marketing Officer
ryan_george@docupace.com
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Which baby car mirrors are best?
While driving is generally a stress-free activity, it can become anxiety-inducing once a baby is involved. Other than hopping in the back, using rear-facing car seats for as long as possible is the safest option.
However, frequently craning your neck to check on your baby can be challenging and even dangerous. Fortunately, baby car mirrors provide an excellent solution. The best products like the So Peep Baby Car Mirror offer parents a crystal clear glance of their baby for peace of mind and a safe driving experience.
What to know before you buy baby car mirrors
Mirror positioning
The best mirror positioning depends on your driving style and the type of headrests your car has. For rear-facing seats, baby car mirrors are generally best positioned on the rear center or passenger headrest so that you can see their reflection from your rearview mirror.
Some mirrors use securing methods like suction cups, but this can present choking hazards if they successfully pull it off. The best ones can securely attach to a headrest at an unreachable distance.
Quality of view
Lower-quality baby car mirrors can sometimes create a warped or blurry view. That’s certainly not something you need when you depend on the product to monitor your baby quickly.
It’s important to note that while some have the same design, they’re not all created equal. For example, consider mirrors that employ convex designs for a full-body view. One might offer a crystal clear reflection, while another reflects something you’d pay to see at a Halloween funhouse.
The last thing you want is to have a mini-heart attack when you look up and suddenly see a distorted reflection of your baby who’s peacefully sleeping and living their best life.
It can be wise to purchase a mirror from a reputable seller with a decent return policy or to check the reviews for the quality of view before purchasing. If all else fails, another costly and potentially more distracting option is to hook up one of the best video baby monitors.
Easy installation
Generally, anything that’s easier to install means there’s less room for installation errors. This is important when it involves a product that can potentially fall and cause injury. The best baby car mirrors install within a couple of minutes using adjustable straps.
Due to road vibrations and movements, it’s natural for mirrors to loosen after some use. You want one that’s easy to install, so you can tighten and secure it quickly and without frustration.
What to look for in a quality baby car mirror
Secure attachments
While it would be nice to have a baby car mirror that comes pre-attached to a headrest for the most security, it’s highly unlikely that’ll happen any time soon.
The safest option is up to the parent’s judgment, but straps that intersect and connect with clips or durable Velcro to the headrest are typically the next most secure option. As an extra layer of security, tying down a few additional bands and clips Macgyver style never hurts.
Simple and safe
It’s safe to assume that parents want to take every possible measure to keep a smile on their baby’s face and to keep an eye on them. However, it’s best to avoid mirrors fitted with extras like LED lights, toys and music.
They add unnecessary weight, which will require more frequent readjusting and can cause more harm in the event of an accident. With baby car mirrors, simplicity is the best design.
Shatterproof
Choosing a shatterproof mirror is the obvious choice for safety reasons. When you’re in an inherently risky situation like a car ride with your baby, you want to ensure there’s one less thing that’ll shatter on impact. Fortunately, a vast majority of manufacturers conduct their own crash testing to ensure a safe, quality product.
However, because the lightweight material is made from plastic or acrylic, it risks a distorted or blurry reflection. As stated earlier, confirming previous buyer reviews will give you the best idea of the quality of view before purchasing.
How much you can expect to spend on baby car mirrors
Depending on the size and brand, you can expect to spend between $15-$30 on a quality baby car mirror.
Baby car mirrors FAQ
How safe are baby care mirrors?
A. As long as it’s properly fastened, it’s unlikely to detach in the event of a bad accident. However, it is still a possibility. In addition to constantly checking and tightening the straps, parents can use mirrors that are shatterproof and have soft, rounded edges.
Are baby car mirrors necessary?
A. Baby car mirrors aren’t necessarily a requirement, and they can become a distraction. However, seeing your face in the reflection can provide them comfort and give you the peace of mind that they’re safe in the back seat.
What’s the best baby car mirror to buy?
Top baby car mirror
What you need to know: This adjustable mirror is large enough for a full, clear view of the back seat.
What you’ll love: It’s shatterproof, and the distortion-free acrylic glass pivots in several directions. The heftier weight gives it a sense of stability, and it features two straps to anchor it in place.
What you should consider: It requires headrests that can move up and down.
Where to buy: Sold by Amazon
Top baby car mirror for the money
Shynerk SH-M-02 Baby Car Mirror
What you need to know: If you want a budget-friendly baby car mirror, this one is a great option and comes with a lifetime warranty.
What you’ll love: The convex design allows parents to have a full view of their baby with a quick glance. It’s adaptable to any headrest and fits most vehicles. You can anchor it securely in a matter of seconds with the horizontal and vertical nylon straps.
What you should consider: There may be some glare since it’s such a large mirror.
Where to buy: Sold by Amazon
Worth checking out
Brica Baby In-Sight Car Mirror
What you need to know: This is one of the most versatile baby car mirrors available, so you can use it with nearly any car. It’s also been crash tested to ensure safety.
What you’ll love: It attaches to both movable and fixed headrests, as well as center back seats. The large shatterproof convex mirror provides a distortion-free reflection and a wide-angle view.
What you should consider: Although it’s versatile, this baby car mirror can’t pivot.
Where to buy: Sold by Amazon and Buy Buy Baby
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Updated results for talquetamab monotherapy and in combination with daratumumab highlighted in oral presentations at the 2022 EHA Annual Congress
VIENNA, June 10, 2022 /PRNewswire/ -- The Janssen Pharmaceutical Companies of Johnson & Johnson announced updated results from the Phase 1 MonumenTAL-1 first-in-human dose-escalation study of talquetamab (NCT03399799), an investigational, off-the-shelf, T-cell redirecting bispecific antibody targeting both GPRC5D, a novel multiple myeloma target, and CD3 on T-cells.1 Results from the study showed encouraging responses in heavily pretreated patients with relapsed or refractory multiple myeloma (RRMM) who received talquetamab at the recommended subcutaneous Phase 2 dose (RP2D) administered weekly (QW) or every two weeks (Q2W).2 These data will be featured during the 2022 European Hematology Association (EHA) Annual Congress as an oral presentation on Saturday, June 11 (Abstract S182)2 and were recently presented at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting (Abstract #8015).3
No new safety signals were identified with longer follow-up of either dose cohort.2 The most common adverse events (AEs) at the 405 µg/kg QW dose were cytokine release syndrome (CRS; 76.7 percent; 3.3 percent Grade 3/4), neutropenia (66.7 percent; 60 percent Grade 3/4), skin-related AEs (66.7 percent; all Grade 1/2), and dysgeusia (63.3 percent; all Grade 1/2).2
The most common AEs at the 800 µg/kg Q2W dose were CRS (79.5 percent; all Grade 1/2), skin-related AEs (72.7 percent; 2.3 percent Grade 3/4), and dysgeusia (56.8 percent).2 Dysgeusia (altered sense of taste) was managed with supportive care and, if needed, dose adjustments.2 Cytopenias were mostly confined to step-up doses and cycles one and two and generally resolved within one week.2 Infections occurred in 46.7 percent (Grade 3/4, 6.7 percent) of patients at the 405 μg/kg QW dose and 38.6 percent (Grade: 3/4, 9.1 percent) at the 800 μg/kg Q2W dose 2
Step-up dosing was used to mitigate against severe CRS, and pre-treatment medications (including steroids) were limited to the step-up and first full doses.2
"Patients with multiple myeloma who are heavily pretreated need new options," said Monique Minnema, M.D., Professor, Department of Hematology, University Medical Center, Utrecht, Netherlands, and principal study investigator.† "The continued deep and durable responses and tolerable safety profile seen in these longer-term data suggest that at both doses, talquetamab may offer a new treatment option for relapsed or refractory patients."
The overall response rate (ORR) to talquetamab treatment was consistent across both doses.2 With a median follow-up of 13.2 months (range 1.1-24), 70 percent (21/30) of response-evaluable patients treated with the 405 µg/kg QW dose achieved a response, 56.7 percent achieved a very good partial response (VGPR) or better, 6.7 percent achieved a complete response (CR), and 23.3 percent achieved a stringent complete response (sCR). With a median follow-up of 7.7 months (range 0.7-16), 63.6 percent (28/44) of response-evaluable patients treated with the 800 µg/kg Q2W dose achieved a response, 56.8 percent achieved a VGPR or better, 11.4 percent achieved a CR, and 9.1 percent achieved an sCR. The median duration of response (DOR) was 10.2 months (95 percent Confidence Interval (CI): 3.0–not estimable) with the 405 µg/kg QW dose and 13.0 months (95 percent CI: 5.3–not estimable) with the 800 µg/kg QW dose.2
Among response-evaluable patients who were triple-class refractory, a response was achieved by 65.2 percent (15/23) of patients treated with the 405 µg/kg QW dose and 67.6 percent (23/34) of patients treated with the 800 µg/kg Q2W dose.2 In patients who were penta-drug refractory, 83.3 percent (5/6) of patients treated with the 405 µg/kg QW dose and 75 percent (9/12) of patients treated with the 800 µg/kg Q2W dose achieved a response.2
"With additional follow-up, these data demonstrate potential durability of talquetamab responses," said Sen Zhuang, M.D., Ph.D., Vice President, Clinical Research and Development, Janssen Research & Development, LLC. "We look forward to fully understanding the potential of this bispecific for relapsed and refractory patients through ongoing clinical development."
The primary objectives of the MonumenTAL-1 study were to identify the recommended subcutaneous Phase 2 dose (part 1) and assess the safety and tolerability of talquetamab at the recommended dose (part 2).2 As of April 6, 2022, 130 patients with multiple myeloma who had relapsed or were refractory or intolerant to established therapies have received talquetamab in the study.2 For part 2, 30 patients received the weekly RP2D of 405 µg/kg QW dosing schedule following step-up doses; 100 percent were triple-class exposed, 80 percent were penta-drug exposed, 76.7 percent were triple-class refractory, 20 percent were penta-drug refractory, and 30 percent had prior B-cell maturation antigen (BCMA)-directed therapy.2 Forty-four patients received the RP2D of 800 µg/kg Q2W; 97.7 percent were triple-class exposed; 68.2 percent were pentadrug exposed, 77.3 percent were triple-class refractory, 27.3 percent were penta-drug refractory, and 27.3 percent had prior BCMAdirected therapy.2
Updated data from the Phase 1b TRiMM-2 Study Evaluating Talquetamab in Combination with DARZALEX FASPRO® (Abstract S183)
Additional data for talquetamab will be featured in an oral presentation at EHA on Saturday, June 11 (Abstract S183).4 The Phase 1b TRiMM-2 study (NCT04108195) evaluated talquetamab in combination with DARZALEX FASPRO® (daratumumab and hyaluronidase-fihj), the CD38-directed monoclonal antibody approved to be given subcutaneously for the treatment of patients with multiple myeloma.4 Results from the study show heavily pretreated patients with multiple myeloma treated with the combination, including talquetamab at the recommended subcutaneous Phase 2 dose (RP2D) administered weekly (QW) or every two weeks (Q2W), achieved high rates of responses, including for patients refractory to anti-CD38 treatment.4
Patients received step-up doses of talquetamab followed by 400 µg/kg QW treatment (n=14) or 800 µg/kg Q2W treatment (n=44), in combination with DARZALEX FASPRO® at the approved dosing schedule.4 With a median follow-up of 5.1 months, the ORR was 80.4 percent (41/51) among all response-evaluable patients.4 Of these patients, 62.7 percent (32/51) achieved a VGPR or better, and 29.4 percent (15/51) achieved a CR or better.4 Among patients with prior exposure to an anti-CD38 antibody, the ORR was 77.3 percent (34/44), and the ORR was 72 percent (18/25) among patients with prior BCMA-targeted treatment.4
No new safety signals were identified with longer follow-up of either dose cohort, and the safety profile for the combination was comparable to each agent as a monotherapy.4 The most common nonhematologic adverse events (AEs) at the 405 µg/kg QW dose were cytokine release syndrome (CRS; 71.4 percent; all Grade 1/2), dysgeusia (71.4 percent; N/A) and dry mouth (71.4 percent; all Grade 1/2).4 The most common AEs at the 800 µg/kg Q2W dose were CRS (77.3 percent; all Grade 1/2), dysgeusia (59.1 percent; N/A), and anemia (43.2 percent; 18.2 percent Grade 3/4). Skin-related and nail disorders were reported in 81 percent of patients.4 Infections were experienced by 53.4 percent of patients (17.2 percent were Grade 3 or higher), and one patient died of pneumonia.4
The primary objectives of the TRiMM-2 study were to identify the recommended Phase 2 dose (RP2D) for each component of the treatment combination (Part 1); characterize the safety of the treatment combination at the RP2D (Part 2); and assess antitumor activity, pharmacokinetics and pharmacodynamics for the combination treatment (Part 3).4 Patients in the study (n=58) had received a minimum three prior lines of therapy or were double refractory to a proteasome inhibitor (PI) and an immunomodulatory agent; patients who had been exposed or refractory to an anti-CD38 therapy more than 90 days prior to the start of the trial were also included, as well as those refractory to anti-CD38 therapy.4
About Talquetamab
Talquetamab is a first-in-class, investigational T-cell redirecting bispecific antibody targeting both GPRC5D, a novel multiple myeloma target that does not shed over time, and CD3, the T-cell receptor.1 CD3 is involved in activating T-cells, and GPRC5D is highly expressed on multiple myeloma cells.5,6 Results from preclinical studies in mouse models demonstrate that talquetamab induces T-cell-mediated killing of GPRC5D-expressing multiple myeloma cells through the recruitment and activation of CD3-positive T-cells and inhibits tumor formation and growth.7
About DARZALEX FASPRO®
In August 2012, Janssen Biotech, Inc. and Genmab A/S entered into a worldwide agreement, which granted Janssen an exclusive license to develop, manufacture and commercialize daratumumab. DARZALEX FASPRO® is the only CD38-directed antibody approved to be given subcutaneously to treat patients with multiple myeloma and now light chain (AL) amyloidosis. DARZALEX FASPRO® is co-formulated with recombinant human hyaluronidase PH20 (rHuPH20), Halozyme's ENHANZE® drug delivery technology.
DARZALEX FASPRO® (daratumumab and hyaluronidase-fihj) is indicated for the treatment of adult patients with multiple myeloma:
- In combination with bortezomib, melphalan, and prednisone in newly diagnosed patients who are ineligible for autologous stem cell transplant
- In combination with lenalidomide and dexamethasone in newly diagnosed patients who are ineligible for autologous stem cell transplant and in patients with relapsed or refractory multiple myeloma who have received at least one prior therapy
- In combination with bortezomib, thalidomide, and dexamethasone in newly diagnosed patients who are eligible for autologous stem cell transplant
- In combination with pomalidomide and dexamethasone in patients who have received at least one prior line of therapy including lenalidomide and a proteasome inhibitor
- In combination with carfilzomib and dexamethasone in patients with relapsed or refractory multiple myeloma who have received one to three prior lines of therapy
- In combination with bortezomib and dexamethasone in patients who have received at least one prior therapy
- As monotherapy in patients who have received at least three prior lines of therapy including a proteasome inhibitor (PI) and an immunomodulatory agent or who are double-refractory to a PI and an immunomodulatory agent
DARZALEX FASPRO® in combination with bortezomib, cyclophosphamide, and dexamethasone is indicated for the treatment of adult patients with newly diagnosed light chain (AL) amyloidosis. This indication is approved under accelerated approval based on response rate. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s).
Limitations of Use
DARZALEX FASPRO® is not indicated and is not recommended for the treatment of patients with light chain (AL) amyloidosis who have NYHA Class IIIB or Class IV cardiac disease or Mayo Stage IIIB outside of controlled clinical trials.
Full prescribing information for DARZALEX FASPRO® is available here.
DARZALEX FASPRO® IMPORTANT SAFETY INFORMATION
CONTRAINDICATIONS
DARZALEX FASPRO® is contraindicated in patients with a history of severe hypersensitivity to daratumumab, hyaluronidase, or any of the components of the formulation.
WARNINGS AND PRECAUTIONS
Hypersensitivity and Other Administration Reactions
Both systemic administration-related reactions, including severe or life-threatening reactions, and local injection-site reactions can occur with DARZALEX FASPRO®. Fatal reactions have been reported with daratumumab-containing products, including DARZALEX FASPRO®.
Systemic Reactions
In a pooled safety population of 898 patients with multiple myeloma (N=705) or light chain (AL) amyloidosis (N=193) who received DARZALEX FASPRO® as monotherapy or in combination, 9% of patients experienced a systemic administration-related reaction (Grade 2: 3.2%, Grade 3: 1%). Systemic administration-related reactions occurred in 8% of patients with the first injection, 0.3% with the second injection, and cumulatively 1% with subsequent injections. The median time to onset was 3.2 hours (range: 4 minutes to 3.5 days). Of the 140 systemic administration-related reactions that occurred in 77 patients, 121 (86%) occurred on the day of DARZALEX FASPRO® administration. Delayed systemic administration-related reactions have occurred in 1% of the patients.
Severe reactions included hypoxia, dyspnea, hypertension, tachycardia, and ocular adverse reactions, including choroidal effusion, acute myopia, and acute angle closure glaucoma. Other signs and symptoms of systemic administration-related reactions may include respiratory symptoms, such as bronchospasm, nasal congestion, cough, throat irritation, allergic rhinitis, and wheezing, as well as anaphylactic reaction, pyrexia, chest pain, pruritus, chills, vomiting, nausea, hypotension, and blurred vision.
Pre-medicate patients with histamine-1 receptor antagonist, acetaminophen, and corticosteroids. Monitor patients for systemic administration-related reactions, especially following the first and second injections. For anaphylactic reaction or life-threatening (Grade 4) administration-related reactions, immediately and permanently discontinue DARZALEX FASPRO®. Consider administering corticosteroids and other medications after the administration of DARZALEX FASPRO® depending on dosing regimen and medical history to minimize the risk of delayed (defined as occurring the day after administration) systemic administration-related reactions.
Ocular adverse reactions, including acute myopia and narrowing of the anterior chamber angle due to ciliochoroidal effusions with potential for increased intraocular pressure or glaucoma, have occurred with daratumumab-containing products. If ocular symptoms occur, interrupt DARZALEX FASPRO® and seek immediate ophthalmologic evaluation prior to restarting DARZALEX FASPRO®.
Local Reactions
In this pooled safety population, injection-site reactions occurred in 8% of patients, including Grade 2 reactions in 0.7%. The most frequent (>1%) injection-site reaction was injection-site erythema. These local reactions occurred a median of 5 minutes (range: 0 minutes to 6.5 days) after starting administration of DARZALEX FASPRO®. Monitor for local reactions and consider symptomatic management.
Cardiac Toxicity in Patients With AL Amyloidosis
Serious or fatal cardiac adverse reactions occurred in patients with AL amyloidosis who received DARZALEX FASPRO® in combination with bortezomib, cyclophosphamide, and dexamethasone. Serious cardiac disorders occurred in 16% of patients, and fatal cardiac disorders occurred in 10% of patients. Patients with NYHA Class IIIA or Mayo Stage IIIA disease may be at greater risk. Patients with NYHA Class IIIB or IV disease were not studied. Monitor patients with cardiac involvement of AL amyloidosis more frequently for cardiac adverse reactions and administer supportive care as appropriate.
Neutropenia
Daratumumab may increase neutropenia induced by background therapy. Monitor complete blood cell counts periodically during treatment according to manufacturer's prescribing information for background therapies. Monitor patients with neutropenia for signs of infection. Consider withholding DARZALEX FASPRO® until recovery of neutrophils. In lower body weight patients receiving DARZALEX FASPRO®, higher rates of Grade 3-4 neutropenia were observed.
Thrombocytopenia
Daratumumab may increase thrombocytopenia induced by background therapy. Monitor complete blood cell counts periodically during treatment according to manufacturer's prescribing information for background therapies. Consider withholding DARZALEX FASPRO® until recovery of platelets.
Embryo-Fetal Toxicity
Based on the mechanism of action, DARZALEX FASPRO® can cause fetal harm when administered to a pregnant woman. DARZALEX FASPRO® may cause depletion of fetal immune cells and decreased bone density. Advise pregnant women of the potential risk to a fetus. Advise females with reproductive potential to use effective contraception during treatment with DARZALEX FASPRO® and for 3 months after the last dose.
The combination of DARZALEX FASPRO® with lenalidomide, thalidomide, or pomalidomide is contraindicated in pregnant women because lenalidomide, thalidomide, and pomalidomide may cause birth defects and death of the unborn child. Refer to the lenalidomide, thalidomide, or pomalidomide prescribing information on use during pregnancy.
Interference With Serological Testing
Daratumumab binds to CD38 on red blood cells (RBCs) and results in a positive indirect antiglobulin test (indirect Coombs test). Daratumumab-mediated positive indirect antiglobulin test may persist for up to 6 months after the last daratumumab administration. Daratumumab bound to RBCs masks detection of antibodies to minor antigens in the patient's serum. The determination of a patient's ABO and Rh blood type are not impacted.
Notify blood transfusion centers of this interference with serological testing and inform blood banks that a patient has received DARZALEX FASPRO®. Type and screen patients prior to starting DARZALEX FASPRO®.
Interference With Determination of Complete Response
Daratumumab is a human immunoglobulin G (IgG) kappa monoclonal antibody that can be detected on both the serum protein electrophoresis (SPE) and immunofixation (IFE) assays used for the clinical monitoring of endogenous M-protein. This interference can impact the determination of complete response and of disease progression in some DARZALEX FASPRO®-treated patients with IgG kappa myeloma protein.
ADVERSE REACTIONS
In multiple myeloma, the most common adverse reaction (≥20%) with DARZALEX FASPRO® monotherapy is upper respiratory tract infection. The most common adverse reactions with combination therapy (≥20% for any combination) include fatigue, nausea, diarrhea, dyspnea, insomnia, headache, pyrexia, cough, muscle spasms, back pain, vomiting, hypertension, upper respiratory tract infection, peripheral sensory neuropathy, constipation, pneumonia, and peripheral edema.
The most common adverse reactions (≥20%) in patients with AL amyloidosis are upper respiratory tract infection, diarrhea, peripheral edema, constipation, fatigue, peripheral sensory neuropathy, nausea, insomnia, dyspnea, and cough.
The most common hematology laboratory abnormalities (≥40%) with DARZALEX FASPRO® are decreased leukocytes, decreased lymphocytes, decreased neutrophils, decreased platelets, and decreased hemoglobin.
Please see full Prescribing Information for DARZALEX FASPRO®.
About Multiple Myeloma
Multiple myeloma is an incurable blood cancer that affects some white blood cells called plasma cells, which are found in the bone marrow.8 When damaged, these plasma cells rapidly spread and replace normal cells in the bone marrow with tumors. In 2020, an estimated 176,000 people worldwide were diagnosed with multiple myeloma.9 In 2022, it is estimated that more than 34,000 people will be diagnosed with multiple myeloma, and more than 12,000 people will die from the disease in the U.S.10 While some people diagnosed with multiple myeloma initially have no symptoms, most patients are diagnosed due to symptoms that can include bone fracture or pain, low red blood cell counts, tiredness, high calcium levels, kidney problems or infections.11
About the Janssen Pharmaceutical Companies of Johnson & Johnson
At Janssen, we're creating a future where disease is a thing of the past. We're the Pharmaceutical Companies of Johnson & Johnson, working tirelessly to make that future a reality for patients everywhere by fighting sickness with science, improving access with ingenuity, and healing hopelessness with heart. We focus on areas of medicine where we can make the biggest difference: Cardiovascular, Metabolism, & Retina; Immunology; Infectious Diseases & Vaccines; Neuroscience; Oncology; and Pulmonary Hypertension.
Learn more at www.janssen.com. Follow us at @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies of Johnson & Johnson.
†Dr. Minnema has served as a consultant to Janssen; she has not been paid for any media work.
*Kyprolis is a registered trademark of Amgen Inc.
Cautions Concerning Forward-Looking Statements
This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995 regarding product development and the potential benefits and treatment impact of teclistamab and DARZALEX FASPRO®. The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Janssen Research & Development, LLC or any of the other Janssen Pharmaceutical Companies and/or Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; manufacturing difficulties and delays; competition, including technological advances, new products and patents attained by competitors; challenges to patents; product efficacy or safety concerns resulting in product recalls or regulatory action; changes in behavior and spending patterns of purchasers of health care products and services; changes to applicable laws and regulations, including global health care reforms; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson's Annual Report on Form 10-K for the fiscal year ended January 2, 2022, including in the sections captioned "Cautionary Note Regarding Forward-Looking Statements" and "Item 1A. Risk Factors," and in Johnson & Johnson's subsequent Quarterly Reports on Form 10-Q and other filings with the Securities and Exchange Commission. Copies of these filings are available online at www.sec.gov, www.jnj.com or on request from Johnson & Johnson. None of the Janssen Pharmaceutical Companies nor Johnson & Johnson undertakes to update any forward-looking statement as a result of new information or future events or developments.
1 Pillarisetti K et al. Blood. 2020;135(15):1232-1243.
2 Minnema M et al. Efficacy and safety of talquetamab, a G protein-coupled receptor family C group 5 member D x CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma (RRMM): updated results from MonumenTAL-1. European Hematology Association 2022 Hybrid Congress. June 2022.
3 Minnema M et al. Efficacy and safety of talquetamab, a G protein-coupled receptor family C group 5 member D x CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma (RRMM): updated results from MonumenTAL-1. American Society of Clinical Oncology 2022 Annual Meeting. June 2022.
4 van de Donk N et al. Novel Combination Immunotherapy for the Treatment of Relapsed/Refractory Multiple Myeloma: Updated Phase 1b Results for Talquetamab (a GPRC5D x CD3 Bispecific Antibody) in Combination With Daratumumab. European Hematology Association 2022 Hybrid Congress. June 2022.
5 Labrijn AF et al. Proc Natl Acad Sci USA. 2013;110:5145.
6 Cohen, Y., et al. Hematology. 2013 Nov; 18(6):348-51.
7 Kumar SK et al. Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group study. Leukemia. 2012 Jan;26(1):149-57.
8 Rajkumar SV. Multiple myeloma: 2020 update on diagnosis, risk-stratification and management. Am J Hematol.2020;95(5):548-5672020;95(5):548-567. http://www.ncbi.nlm.nih.gov/pubmed/32212178
9 Cancer.Net. "Multiple Myeloma: Statistics." Available at:https://www.cancer.net/cancer-types/multiple-myeloma/statistics#:~:text=Worldwide%2C%20an%20estimated%20176%2C404%20people,worldwide%20died%20from%20multiple%20myeloma. Accessed June 3, 2022.
10 American Cancer Society. "Key Statistics About Multiple Myeloma." Available at:https://cancerstatisticscenter.cancer.org/?_ga=2.84250769.967379196.1642100198-1705811479.1642100198#!/. Accessed June 2022.
11 American Cancer Society. "What Is Multiple Myeloma?" Available at: https://www.cancer.org/cancer/multiple-myeloma/about/what-is-multiple-myeloma.html. Accessed June 2022.
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SOURCE The Janssen Pharmaceutical Companies of Johnson & Johnson | https://www.wmbfnews.com/prnewswire/2022/06/10/janssen-presents-updated-results-evaluating-first-in-class-gprc5d-bispecific-antibody-talquetamab-heavily-pretreated-patients-with-multiple-myeloma/ | 2022-06-10T13:36:50Z | https://www.wmbfnews.com/prnewswire/2022/06/10/janssen-presents-updated-results-evaluating-first-in-class-gprc5d-bispecific-antibody-talquetamab-heavily-pretreated-patients-with-multiple-myeloma/ | false | 14 |
New Bay Area adventure center, rentals, and multiday trips added to inspire 3 million outdoor participants
SEATTLE, June 10, 2022 /PRNewswire/ -- REI Co-op is expanding its domestic multiday adventure travel trips, guided day tours, rentals and adventure center locations as part of a continued multi-year strategy designed to get 3 million people outside each year. Consumer interest in the outdoors and related activities has soared across the country in recent years, and many have turned to spending time in nature for physical and mental well-being during the pandemic. REI has grown its experiences offerings by more than 60 percent in the last 12 months to meet the demand.
"The co-op was founded in 1938 by a group of 23 friends who loved to explore nature and share their passion and expertise with others. REI strives to build on this tradition and community through the expertise of our retail staff as well as our award-winning guides across the country," said Mark Seidl, REI Experiences divisional vice president. "As the nation's leading outdoor experience operator, we are working to expand our offering to new locations that will empower all to experience urban and iconic destinations in new and unforgettable ways."
This month, REI opens the doors of a new Bay Area Adventure Center in Richmond, California with bike, paddling and camping gear rentals. The facility will be a home base for a 50-person guide team that leads day tours and multiday trips in the region. REI also hosts kayaking classes and day tours from the adjacent Richmond Marina and broader programing throughout the Bay Area.
To further complement REI's regional ecosystem of experience offerings in the Bay Area, REI will soon launch bike and e-bike rentals in the heart of Fisherman's Wharf for urban cycling opportunities along San Francisco's famed waterfront and minutes from the Presidio and Golden Gate Bridge. According to the San Francisco Travel Association, more than 75 percent of the city's visitors include Fisherman's Wharf during a planned trip. The location will open in early August.
In addition to the Bay Area facility, the co-op operates an Arizona Adventure Center in Scottsdale that offers gear rentals and day tours while serving as the base for the co-op's multiday guide teams in the Southwest. REI also has seasonal rentals and programming through two boathouses in Bellevue, Washington and a winter snowshoe rental pop-up at Snoqualmie Pass outside Seattle, Washington.
REI Experiences offers 124 multiday adventure travel trips led by professional local guides. Fully hosted small groups explore the country's natural places as guests hike, backpack, cycle, paddle, climb, snowshoe and more. So far this year, 22 new trips have been added to REI's active travel assortment, of which more than half are hiking and backpacking itineraries. REI now operates a new private signature camp adjacent to Bryce National Park that is featured in five itineraries. Other new trips include:
- Four Shenandoah National Park trips offer classic camping, backpacking or lodge-based options.
- Two Death Valley National Park trips double REI's assortment to four itineraries for hiking and cycling with nights spent camping or at a hotel.
- Three new Grand Canyon National Park trips bring REI's offering to 14 total itineraries. Recently added trips offer new ways to experience the park, including a six-day family adventure of the Grand Canyon and Lake Powell, a four-day hiking and lodge-based trip, and a four-day Thunder River Loop women's backpacking trip.
- A Pt. Reyes National Seashore backpacking trip to explore the scenic and diverse habitats and wildlife over three days.
- A Trans Catalina Islands backpacking trek features jaw dropping views, pristine beaches and prolific wildlife over a 38.5-mile adventure.
- Three new San Juan Islands trips bring REI's assortment to 11 trips in the region with curated adventures for hikers, cyclists, families and women.
The co-op will continue to add more trips to meet continued demand especially for weekend adventurers, travelers 35 years and younger, women and families.
In addition to multiday adventure trips, REI continues to offer day tours and educational programming in 14 cities through a wide range of expertise for anyone to learn or sharpen their outdoor skillsets for camping, cycling, paddling, climbing and more. The co-op's most popular classes are Wilderness Survival Skills, Map & Compass, as well as the Wilderness First Aid and Wilderness First Responder training courses from a decade-long partnership with the National Outdoor Leadership School (NOLS). The co-op is also a leader in teaching youth and adults how to ride a bike.
REI is a specialty outdoor retailer, headquartered near Seattle. The nation's largest consumer co-op, REI is a growing community of 21.5 million members who expect and love the best quality gear, inspiring expert classes and trips, and outstanding customer service. REI has 175 locations in 41 states and the District of Columbia. If you can't visit a store, you can shop at REI.com, REI Outlet or the REI shopping app. REI isn't just about gear. Adventurers can take the trip of a lifetime with REI's active adventure travel company that runs more than 100 itineraries across the country. In many communities where REI has a presence, professionally trained instructors share their expertise by hosting beginner-to advanced-level classes and workshops about a wide range of activities. To build on the infrastructure that makes life outside possible, REI invests millions annually in hundreds of local and national nonprofits that create access to—and steward—the outdoor places that inspire us all.
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SOURCE REI Co-op | https://www.wctv.tv/prnewswire/2022/06/10/rei-announces-domestic-experiences-program-growth-under-continuing-multi-year-investment/ | 2022-06-10T13:38:01Z | https://www.wctv.tv/prnewswire/2022/06/10/rei-announces-domestic-experiences-program-growth-under-continuing-multi-year-investment/ | true | 12 |
PORTLAND, Ore., June 10, 2022 /PRNewswire/ -- Boulder Care, a telehealth provider of medical treatment and long-term support for people overcoming substance use disorders, today announced a $36 million Series B raise.
This brings the company's funding to over $50 million, advancing its mission to meet an urgent, growing need for evidence-based addiction care as 40 million Americans report increased substance use in the last year1.
Series B investors include Qiming Venture Partners (US), Goodwater Capital, and Laerdal Million Lives Fund, as well as repeat investors First Round Capital, Greycroft, Tusk Venture Partners and Gaingels.
With this funding, Boulder will triple the size of its medical group, expand into multiple markets, and treat more patients under unique payer contracts that hold the company accountable for outcomes.
"At Boulder, we envision a dramatically better safety net for the most underserved – starting with SUD care delivered with humility and empowerment. Critical services should be accessible regardless of location, income, race & ethnicity, or personal choices about drug use.
Linking arms with insurers has helped Boulder make care affordable for low-income Americans who are fighting hard to recover. With investor support, we'll deepen dozens of valuable health plan & employer relationships all over the country."
—Stephanie Strong, CEO
The company generates revenue from in-network reimbursement, predominantly by Managed Medicaid. Most patients pay nothing out-of-pocket.
Medicaid covers 1 in 5 Americans, representing $662 billion in annual spend, and is poised to grow in an economic downturn2. Despite millions of beneficiaries with complex, costly needs, digital providers rarely contract with Medicaid.
In addition, half of Boulder's LTM revenue is attributable to alternative payment arrangements for a set of comprehensive services delivered by a multidisciplinary care team.
"We are moving the industry toward transparency and value, recognizing cash-pay models have excluded the very people who need care most," says
Strong.
Since its last financing, Boulder has served several thousand patients with opioid and alcohol use disorders, grown revenue by more than 10X, and launched with >20 enterprise customers – like Regence and Anthem – and employers like Comcast and Hewlett-Packard through ComPsych EAP. 100% of customers have renewed YoY since inception.
Boulder is dedicated to health equity, with >80% of its patients living below the poverty line and 25% residing in rural areas. Special programs ensure groups typically excluded from SUD treatment are successful in care, including patients who are incarcerated, living unsheltered, over 65, or pregnant.
This commitment to value-based care has enabled Boulder to achieve industry-leading outcomes for thousands of patients, including:
- ~70% 12-month and ~90% 1-month retention rates
- A Net Promoter Score of 90
- 93% of patients meeting their goals of reducing or eliminating unwanted substance use
While many digital providers rely on paid ads to grow, Boulder primarily engages patients through local provider networks, hospitals, community-based organizations, and insurers. This approach ensures
Boulder's services are integrated on a broader continuum of care.
In addition to medical management, the company's Certified Peer Recovery Specialists and Case Managers provide comprehensive support for complex legal, financial, and housing needs.
Accredited by the Joint Commission, partnered with leading health plans, and conducting research funded by the NIH's National Institute on Drug Abuse, Boulder is committed to social impact by responsibly scaling high-quality services across the country.
Boulder Care offers telehealth addiction treatment grounded in kindness, respect, and unconditional support.
Patients securely access a dedicated Care Team 24/7, including Clinicians for expert medical care and medication management, Care Advocates for care coordination and navigation, and Certified Peer Recovery Specialists with their own lived experience.
Boulder helps achieve better health outcomes, patient satisfaction, and long-term retention in care — while reducing costs through innovative value-based payment arrangements. Millions of people nationwide have access to Boulder through partnerships with leading health plans and employers.
For more information, please visit www.boulder.care.
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SOURCE Boulder Care | https://www.wect.com/prnewswire/2022/06/10/boulder-care-raises-36m-series-b-serve-americas-most-vulnerable-patients-with-substance-use-disorders/ | 2022-06-10T13:39:57Z | https://www.wect.com/prnewswire/2022/06/10/boulder-care-raises-36m-series-b-serve-americas-most-vulnerable-patients-with-substance-use-disorders/ | false | 11 |
Inflation rises at fastest pace since 1981, pushed up by record gas prices
By Chris Isidore, CNN Business
The pain of higher prices continues for US consumers.
Record gas prices drove inflation to 8.6% for the 12 months ending in May, higher than the pace in April, according to the latest Consumer Price Index, the government’s basic inflation measure.
The reading for core CPI, which strips out volatile food and energy prices, posted a 6% increase over the same period, higher than the previous month’s level. Both readings are among the biggest jumps in prices experienced by consumers since 1981.
Energy prices overall rose 34.6% compared to a year ago, driven by a nearly 50% jump in gas prices over the last year, with a 4.5% increase in just the last month. But other forms of energy were also much higher. The cost of electricity rose 12%.
And it’s not just energy driving prices higher. Food prices rose 10.1%, the first double-digit increase since 1981. The shelter index, which measures rents and other housing costs, posted a 5.5% increase, the biggest 12-month gain since 1991.
The high pace of inflation means the Federal Reserve is all but certain to continue to aggressively raise interest rates when it meets next week.
The-CNN-Wire
™ & © 2022 Cable News Network, Inc., a WarnerMedia Company. All rights reserved. | https://ktvz.com/news/2022/06/10/inflation-rises-at-fastest-pace-since-1981-pushed-up-by-record-gas-prices/ | 2022-06-10T13:43:28Z | https://ktvz.com/news/2022/06/10/inflation-rises-at-fastest-pace-since-1981-pushed-up-by-record-gas-prices/ | false | 11 |
A Delhi court on Friday sent gangster Lawrence Bishnoi to four more days of police custody, in connection with an old Arms Act case.
Bishnoi was produced on Sunday before the Patiala House Court which sent him to five days police custody, and was brought before the court again after the expiration of his remand.
The Delhi Police’s Special Cell submitted before the court that they need four days’ custody of the gangster in the present case, which is in relation to another jailed gangster Jaggu Bhagwanpuria’s arms supply to Bishnoi.
Jasdeep Singh aka hagwanpuria is infamous for his criminal activities mostly in the Majha area of Punjab. Jaggu and his gang were the main accused in the killing of the son of a Sarpanch in Dhianpur village on Diwali night.
During interrogation, Bishnoi had told the Special Cell about the hideout and names of the arms suppliers, who are based in Punjab, Haryana, Uttrakhand and Rajasthan. Police suspect these suppliers could be the ones who helped the killers of Punjabi singer-politician Sidhu Moosewala — one being headed by Ranjeet, resident of Faridkot, another Vijay, a resident of Haryana-Rajasthan border area, and one more by Raka.
Bishnoi came to headlines soon after the murder of Punjabi singer Shubhdeep Singh, popularly known as Sidhu Moosewala, allegedly on behalf of his gang, took place on May 29.
“The Delhi Police didn’t mention the Sidhu Moosewala case in their remand application. But he was sent to five more days police custody,” said advocate Vishal Chopra, the counsel of Bishnoi.
The sources have, however, claimed that the arms suppliers whose names have come up during the course of investigation, could be the same who supplied arms to the killer of Moosewala. | https://www.thestatesman.com/cities/delhi/gangster-lawrence-bishnoi-sent-4-days-police-custody-1503079890.html | 2022-06-10T13:45:06Z | https://www.thestatesman.com/cities/delhi/gangster-lawrence-bishnoi-sent-4-days-police-custody-1503079890.html | false | 8 |
Darul Uloom Taleem Ul Quran To Clash Nowshera Minority In Grand Soccer Final
Zeeshan Mehtab Published June 10, 2022 | 05:00 PM
PESHAWAR, (APP - UrduPoint / Pakistan Point News - 10th Jun, 2022 ) :Darul Uloom Taleem Quran will clash against Nowshera Minority team of Bacha Gul XI to be played at Qayyum sports Complex on Saturday.
Director General Sports Khalid Khan and Director Youth Irfan Ullah will grace the occasion as guests. The final will start at 5.00 pm while the prize distribution ceremony will be organized at 6.00 p.m.
Earlier in the last league round match Darul Uloom Sarhad defeated Darul Uloom Chitral by 3-1 in a thrilling match played at a rattling pace. The match started on a fast tempo and both Darul Uloom Sarhad and Darul Uloom Shahi Masjid Chitral played excellent games by raiding each other's territory.
Darul Uloom Shahi Masjid Chitral took the lead through Qari Inam Ullah on the field attempt and till the end of the first session Darul Uloom Shaid Masjid team was leading by 1-0.
It was the second session in which Darul Uloom Taleemul Quran managed their position and soon succeeded in leveling the tally 1-1. This was Qari Amin Ullah who slammed in a beautiful goal on the field attempt before dodging three defenders in a row.
After leveling the tally the players of Darul Uloom Taleem Ul Quran put in more pressure and scored two more goals on the field attempt when Qari Ibrahim and Qari Asmat Ullah scored one goal each to make the tally 3-1. Thus Darul Uloom Taleem Ul Quran won the match by 3-1 and also moved to the final of the Soccer League.
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All rights of the publication are reserved by UrduPoint.com. Reproduction without proper consent is not allowed. | https://www.urdupoint.com/en/sports/darul-uloom-taleem-ul-quran-to-clash-nowshera-1523413.html | 2022-06-10T13:45:22Z | https://www.urdupoint.com/en/sports/darul-uloom-taleem-ul-quran-to-clash-nowshera-1523413.html | false | 1 |
Flick tells German team to ignore Hungary fans' whistles in Budapest
Issued on:
Berlin (AFP) – Germany coach Hansi Flick has told his side to keep their composure in Budapest during Saturday's Nations League match against Hungary, where the home crowd is expected to give the Germans a hostile reception.
"Everyone of us has played so many games where the atmosphere was heated," Flick said Friday.
"There may be whistles (from Hungary fans) but once the (referee's) whistle goes, the focus is on the game."
There is history between the German team and Hungarian fans from last June's 2-2 draw in Munich during the Euro 2020 group stages.
After scoring the equaliser, Germany midfielder Leon Goretzka made a heart gesture with his hands to Hungarian fans, who had turned their backs to the pitch before kick off during the German national anthem.
Thomas Mueller said Goretzka's gesture reflected the team's feelings towards visiting fans, who provoked the Germans throughout the game.
"Leon's action was spontaneous and a great reaction to what happened," Mueller said Friday.
"The Hungarian fan block didn't show its best side. His (gesture) spoke from our hearts."
Hungary pulled off a shock 1-0 home win over England last Saturday, when visiting English players were booed by the Budapest crowd for taking a knee - to promote anti-racism - before kick-off.
Both the German and English teams took a knee before Tuesday's 1-1 draw in Munich, but Mueller said there are no plans for the Germany team to repeat the gesture in Budapest.
"The English kneeled as part of their campaign. We think it's a good thing, that's why we took part," Mueller explained.
"We're open to campaigns that represent our values, but nothing is planned (before the game in Budapest)."
After draws against both Italy and England, Flick is set to name his strongest team having ruled out resting Germany captain Manuel Neuer in goal.
Five months before the World Cup kicks off in Qatar, Flick still needs to settle on his first-choice striker.
Timo Werner started against Italy in Bologna, then his Chelsea team-mate Kai Havertz was used up front against England.
Flick hinted that Werner will start in Budapest and called on the 26-year-old to add to his tally of 22 goals in 51 internationals.
"We need players who are in form, which is crucial for Qatar. We don't have time to make any adjustments," said Flick.
"It is quite possible that he (Werner) will play from the start.
"He can score goals, which always gives him confidence."
© 2022 AFP | https://www.france24.com/en/live-news/20220610-flick-tells-german-team-to-ignore-hungary-fans-whistles-in-budapest | 2022-06-10T13:50:09Z | https://www.france24.com/en/live-news/20220610-flick-tells-german-team-to-ignore-hungary-fans-whistles-in-budapest | true | 2 |
It's time to stop cashing in on the Pride movement. These are the brands making a real difference to LGBTQIA+ lives
It takes more than slapping a rainbow flag on a product and declaring yourself a Pride ally to make a real difference to LGBTQIA+ lives. While support for the community has never been more apparent across social media and product packaging, there remains some tokenistic brands that are cashing in on a movement that they’re not tangibly helping.
But, there’s a regiment of beauty brands truly putting their time, energy and money where their mouth is to aid the LGBTQIA+ community in the ongoing fight for acceptance and equal rights – providing funding for legal aid, support lines and safe spaces to those who need it. Like Pride itself, these are the loud, proud, celebratory and inclusive brands we can really get behind. | https://www.glamourmagazine.co.uk/gallery/lgbtq-pride-makeup-brands | 2022-06-10T13:50:18Z | https://www.glamourmagazine.co.uk/gallery/lgbtq-pride-makeup-brands | true | null |
(The Hill) — Britney Spears’s first husband, Jason Alexander, was arrested after crashing her wedding on Thursday as she was set to tie the knot with partner Sam Asghari.
In an Instagram livestream, Alexander was shown approaching Spears’s home in Thousand Oaks, California, and entering before being stopped by security officers.
“Don’t put your hands on me,” he is heard saying at the beginning of the video. “Please don’t put your hands on me.”
He continued live streaming and exited the home, approaching an event tent.
“Hey, where’s Britney at?” he asked a bystander. “I’m Jason Alexander, her first husband, I’m here to crash the wedding, brother.”
He was later accosted by officers and arrested for an out-of-county warrant, the Ventura Country Sheriff’s department confirmed to The Hill. Police are still investigating the scene.
TMZ first reported the arrest.
Alexander and Spears married in 2004 in Las Vegas. The pair, who were childhood sweethearts, had the union annulled only 55 hours later.
Spears was set to marry Asghari, a 28-year-old personal trainer, on Thursday. It will be her third marriage.
The two were engaged in September after Spears was freed from her 13-year conservatorship. | https://www.wkbn.com/news/national-world/britney-spearss-ex-husband-arrested-after-crashing-her-wedding/ | 2022-06-10T13:52:09Z | https://www.wkbn.com/news/national-world/britney-spearss-ex-husband-arrested-after-crashing-her-wedding/ | true | 16 |
Florida Supreme Court justices expressed skepticism Thursday about a challenge by cities and counties to a 2011 state law that threatens stiff penalties if local officials pass gun-related regulations.
During arguments in the closely watched case, justices asked questions and made comments that indicated they did not agree with city and county contentions that the law is unconstitutional.
“You make a very plausible kind of policy argument,” Justice Carlos Muniz said at one point to Edward Guedes, an attorney for the local governments. “But it just doesn’t seem like there’s any sort of constitutional foundation for what you’re talking about.”
At another point, Chief Justice Charles Canady pointed to part of the state Constitution that involves the relationship between the Legislature and municipalities.
“Our (previous) cases are very clear about the superiority of legislative power in this arena. Am I wrong about that?” Canady asked Guedes. “And so that’s why this whole case is kind of mystifying to me because underlying what the Legislature has done (in the gun law) is this express constitutional provision.”
Florida since 1987 has barred cities and counties from passing regulations that are stricter than state firearms laws, and the penalties in the 2011 law were designed to strengthen that “preemption.” The law, for example, could lead to local officials facing $5,000 fines for passing gun regulations.
The case does not challenge the underlying 1987 law but contends the penalties in the 2011 law are unconstitutional, in part, because they violate legal immunities for local officials and governments. Also, Guedes argued that the 2011 law violates the constitutional separation of powers because it would lead to courts delving into the motivations or intentions of local elected officials.
More than 30 cities and counties and dozens of local officials challenged the 2011 law after the 2018 mass shooting at Marjory Stoneman Douglas High School in Parkland that killed 17 people. State Agriculture Commissioner Nikki Fried joined the challenge, which has drawn briefs from prominent groups on both sides of the issue, including the National Rifle Association and the Giffords and Brady gun-control organizations.
The 1st District Court of Appeal last year upheld the law, spurring the cities and counties to go to the Supreme Court.
While the timing was coincidental, Thursday’s arguments came amid a refueled national debate about gun issues after mass shootings in Uvalde, Texas, and Buffalo, N.Y. Florida Democrats also have sought to force a special legislative session on gun issues, though the idea stands virtually no chance amid Republican opposition.
Along with penalties against individual local officials for passing gun-related regulations, the 2011 law would allow members of the public and organizations to receive damages and attorney fees if they successfully sue local governments for improper gun regulations.
Attorneys for the local governments wrote in a 2019 court document that city and county officials had been urged to take action after the Marjory Stoneman Douglas shooting. Those requests involved such things as requiring procedures or documentation to ensure compliance with background checks and waiting periods for gun purchases and requiring reporting of failed background checks.
But the attorneys said local governments refrained from going ahead with the proposals because of the potential penalties in state law.
During Thursday’s arguments, Guedes did not dispute the Legislature’s authority to preempt local decision-making power but took issue with the potential punishments.
“There is no question, underlying all of this is the notion of the preeminence of the state Legislature to preempt substantive areas of law. We don’t disagree with that,” Guedes said. “But this is a legislative firehose to put out a birthday candle.”
While justices had extensive back and forth with Guedes, justices only briefly questioned state Chief Deputy Solicitor General Daniel Bell. In part, Bell pointed to the Legislature’s authority over local governments.
“Local officials have only those powers that are not inconsistent with general law, which means they are subject to the plenary control of the Legislature,” Bell said. “With that hierarchy established, there is no reason the Legislature wouldn’t be able to provide penalties for its statute.”
The Supreme Court typically takes months before issuing rulings. The case stems from three lawsuits that were consolidated in Leon County circuit court. The challenges were filed by cities and counties from various parts of the state, such as Tallahassee, Gainesville, Orlando, St. Petersburg, Fort Lauderdale and Miami Beach.
– News Service Assignment Manager Tom Urban contributed to this report. | https://www.winknews.com/2022/06/10/florida-supreme-court-justices-skeptical-of-challenge-to-gun-law/ | 2022-06-10T13:53:55Z | https://www.winknews.com/2022/06/10/florida-supreme-court-justices-skeptical-of-challenge-to-gun-law/ | false | 10 |
DETROIT, June 10, 2022 /PRNewswire/ -- SME and the Rapid News Group welcomed thousands of members of the Additive Manufacturing (AM) community back for another successful installment of the industry's largest and most influential event, RAPID + TCT 2022, May 17-19 at Huntington Place in Detroit. The 31st edition of the three-day event featured the latest in 3D-printing technology from the industry's leading product and service providers, a full schedule of speakers including three keynote presentations and several panel presentations in the SME ZONE theater through industry partners and SME technical communities. SME Executive Director and CEO Robert "Bob" Willig made the announcement.
"The incredible activity on the exhibit floor across all three days was a clear indicator of the excitement and success of this year's RAPID + TCT event in downtown Detroit," said Willig. "From the engaging keynotes to the insightful thought leadership panels to the in-depth technical conference to the buzz heard all around the exhibits, the next-level networking at RAPID + TCT 2022 exceeded expectations in every way. The AM innovations don't end when the event is over though. Advancements are ongoing, and we look forward to identifying the next challenges and helping manufacturers find solutions using this ever-evolving technology."
Attendees participated in RAPID + TCT 2022 in-person and virtually through the RAPID + TCT Digital Experience — from 42 states and 38 countries. Building upon the success of last year, the RAPID + TCT Digital Experience showcased livestreaming of all keynotes and thought leadership panels from both the Main Stage and the SME ZONE theater. Visitors and delegates were able to connect face-to-face with more than 400 exhibiting companies represented on the exhibit floor.
The RAPID + TCT 2022 Conference followed seven unique tracks with sessions tagged by where one is in their AM journey: Evaluation, Adoption and Optimization of Additive Manufacturing. Throughout the three-day event, presentations delivered by some of the industry's best provided insight into AM applications already in existence across a wide range of industries, as well as thoughts on what the future holds as the technology continues to change.
Barbara Humpton, president and CEO, Siemens USA, delivered the first keynote address of the week. Her talk touched on the role of AM in driving the Fourth Industrial Revolution and Siemens' work in digital twin technology enabling the success of NASA's Mars 2020 Perseverance Rover. She also spoke about "glocalization," the process of reflecting global innovation with local production capabilities — accelerated by the response to COVID-19. As the space continues to grow, AM is enabling localization of production, increasing resiliency and inspiring a new generation of industry leaders.
Also on day one, Slade Gardner, PhD, president and founder of Big Metal Additive, was recognized as the recipient of SME's AM Industry Achievement Award. Established in 2008, the award was developed by SME's AM Community to recognize an individual, team or company for outstanding accomplishments that have had significant impact within AM, or in any industry through the application of AM technologies. Gardner is recognized for his contributions over a distinguished career for advancing industrial metal additive manufacturing and for recent work with large-scale metal-hybrid AM. The full list of winners of the 2022 Additive Manufacturing Community Awards can be found on the RAPID + TCT website.
The show's second keynote speaker, Brian Baughman, manufacturing chief engineer at Honeywell Aerospace, delivered an address centered on the possibilities unlocked by AM technologies. Baughman remarked on maximizing efficiency and keeping costs low, advice for the industry in developing better, more widely adopted technologies and offered examples from projects completed by Honeywell Aerospace.
Rounding out the show as the third keynote speaker on the mainstage, Caralynn Nowinski-Collens, MD, CEO of Dimension Inx, spoke about the application of exciting AM technologies in the medical field including biofabrication and 3D-printable biomaterials. She made it clear that medical has made incredible, futuristic advancements just in the past year, and the industry is poised for more growth.
In the exhibit hall, AM companies from all over had products and machines on display, including 3D Systems, Desktop Metal, EOS, Formlabs, HP, Massivit, Nexa3D, Stratasys, Thermwood and many more. Exhibitors showcased new technologies, materials, processes and software solutions, giving attendees an exclusive, hands-on look at the best the AM industry has to offer. Enthusiasts across verticals were in attendance, representing industries such as automotive, aircraft/aerospace, construction, defense, electronics, industrial and commercial, machinery, medical/surgical/dental, R&D, consumer products and consulting/engineering.
The SME Education Foundation's Bright Minds Program welcomed nearly 1,000 middle and high school students with a schedule tailored for AM introduction with hands-on workshops, high-tech demonstrations and dynamic speakers from some of the top names in AM, including a separate keynote from Brian Baughman. The program also offered students and employers alike the opportunity to network and connect with leaders from some of the top engineering programs in the country.
The 2022 edition of RAPID + TCT also saw the introduction of the AM Industry Celebration — a gathering of more than 2,000 additive manufacturing professionals and enthusiasts who joined SME along with strategic partners TCT, America Makes, AMUG and Women in 3D Printing to celebrate the advancements of the past 30+ years of this disruptive technology while looking forward to the exciting and dynamic future that AM is creating across many industries.
RAPID + TCT 2023 will take place May 2-4, 2023, at McCormick Place in Chicago. To learn more about the event, visit rapid3devent.com.
About RAPID + TCT
For more than 30 years, SME and RAPID have defined the crucial role of additive manufacturing and empowered the establishment of an industry that continues to conceive, test, improve and manufacture new products at a faster, more cost-efficient pace. In 2017, the two industry leaders in 3D technology events, SME and The TCT Group, partnered to produce the annual RAPID + TCT event. For users and suppliers alike, the event is the premier destination for those who provide technology and for those who need to understand, explore and adopt 3D printing, additive manufacturing, 3D scanning, CAD/CAE, metrology and inspection technologies. For more information, visit rapid3devent.com, follow @RAPID_Event on Twitter or on LinkedIn.
About SME
SME connects manufacturing professionals, academia and communities, sharing knowledge and resources to build inspired, educated and prosperous manufacturers and enterprises. With 90 years of experience and expertise in events, media, membership, training and development, and also through the SME Education Foundation, SME is committed to promoting manufacturing technology, developing a skilled workforce and attracting future generations to advance manufacturing. Learn more at SME.org, follow @SME_MFG on Twitter or facebook.com/SMEmfg.
About Rapid News Publications Ltd & The TCT Group
Rapid News Publications Ltd, the owner of the TCT Group, has been a leading authority in additive manufacturing, 3D printing, design and engineering technology for 30 years. A rich mix of live events and all-encompassing media portfolio enables TCT to deliver business critical intelligence, connecting the additive community across Europe, North America and Asia. The TCT Group (thetctgroup.com) is owned by Rapid News Publications Ltd (rapidnews.com) a member of the AEO (Association of Event Organizers) and BPA Worldwide.
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SOURCE SME | https://www.wabi.tv/prnewswire/2022/06/10/rapid-tct-2022-north-americas-largest-additive-manufacturing-event-marks-successful-return-detroit/ | 2022-06-10T13:55:55Z | https://www.wabi.tv/prnewswire/2022/06/10/rapid-tct-2022-north-americas-largest-additive-manufacturing-event-marks-successful-return-detroit/ | true | 12 |
VANCOUVER, BC – Amid a tumultuous time in Canadian soccer, there was finally a match, as Alphonso Davies scored a brace as the Canadian Men’s National Team defeated Curacao 4-0 at BC Place in Vancouver.
While the crowd was a far cry from what could have been, over 17,000 turned up to see Davies’ return as the CanMNT took the next step in their World Cup preparation, kicking off their Concacaf Nations League campaign.
Although the result is a benefit for Canada moving on in the Nations League group stages, the game provided head coach John Herdman with the opportunity to iron out his lineup ahead of Canada’s first World Cup in 36 years.
Quick recap:
Alphonso Davies returned to the CanMNT and scored twice as Canada dominated Curacao en route to a 4-0 victory on Thursday night. Steven Vitoria and Lucas Cavallini added the other two goals. While protesters tying themselves to goalposts forced a brief distribution in the second half, the 38th-ranked Canadians proved too much for their Caribbean foes, as Canada moved to 1-0-0 in Concacaf Nations League play.
Zoning in on a true best eleven
With roughly 13 available training sessions and at most four preparation matches until the World Cup, Herdman rolled out a first-choice starting lineup for a lesser opponent. With preparation in mind, Canada turned to a 4-4-2, one that could very well be on the field come November.
While structured as a 4-4-2, it was a very fluid formation, with the fullbacks and wingers swapping, leaving Curacao perplexed with their runs.
Within the first few minutes, Adekugbe and Buchanan had already swapped spots, as the former sent an early cross in that Canada failed to convert. Yet, the ability to attack down the flanks and exploit wide areas was critical to Canada’s success in the first half.
“We started well tonight, and I thought we were relentless,” Herdman told the media. “With the pace, we’re encouraging them to get the ball outside; there’s a bit more intricacy around how you do that to create that space for people like Davies and Buchanan; it allows them to draw defenders.”
Additionally, Stephen Eustquio and Atiba Hutchinson added a calming presence to midfield, allowing Canada to hold the ball up, and distribute to their attackers, whether on the wing with the fluid fullbacks or straight up the attackers.
Aside from the first-choice starting lineup, Canada showed that again, they don’t just rely on Davies, even as he returned. Cavallini, who has played brilliantly as of late for Vacnvouer, made an impact, scoring a goal as a substitute, while centre-back Steven Vitoria also found his way onto the scoresheet.
While Herdman switched up the lineup in the second half,e eventually shifting Davies to a striker role with no outright forwards in the lineup, the first half showed that Canada has a good sense of their identity heading into Qatar.
Let Alphonso cook
If there were doubts that Alphonso Davies wouldn’t fit back into the Canadian team, those are now silenced. From kickoff, the former Vancouver Whitecap, now Bayern Munich star, made his presence known to the Curacao defenders, going 1-on-1, often beating his man down the left-wing.
Davies led the way on Thursday night with the opening goal in the 27th minute before adding a second in the 78th. His first goal, taken from the spot, resulted from the 21-year-old bursting into the penalty area with speed and drawing a foul in the box.
As he did as a teenager with the Whitecaps, Davies took on defenders quickly, bringing the fans to their feet whenever he touched the ball. However, his ability to work in tandem with left-back Alistair Johnston stood out.
“Sometimes what they’re doing off the ball is more important than what they’re doing on,” Herdman said on Buchanan and Davies.
As mentioned above, Canada’s wide players worked together on the wings, and Davies often overlapped with Johnston. However, with his attacking abilities, the youngster roamed into the middle, beating several players on blistering runs throughout the night.
In the second half, Herdman pushed Davies up as a striker and is confident he could play at the highest level.
“It felt good to come back to the stadium where I played from 15-17,” Davies said. “All of the memories came back to me… scoring; it brought back all my memories from my last game with the Whitecaps.”
After missing the final two World Cup qualifying windows, it took a few moments for Davies to re-integrate himself into the Canadian lineup. Still, he is undoubtedly raring a ready-to-go for the next match against Honduras and the upcoming World Cup.
Focus on the soccer
With the emotional week that transpired for Canadian soccer, mich of the lustre had rusted from the idea of playing Curacao. However, as the players warmed up and the match began, the focus turned back to soccer and preparing for the World Cup.
“We were back to business, training, playing and back to what we like to do and we are good at,” Samuel Piette said post-match. “I think we did well tonight, and it was unfortunate not to have the Panama game.”
It’s an essential factor for Canada to have the focus back on the field, and more importantly, the labour issues, now in the hands of legal representation, something that every player was very adamant about.
In the bigger picture, everyone wants to see Canada succeed at the World Cup. Although Lucas Cavallini says “the boys are always ready” regarding Qatar 2022, there is still a long way to go before kickoff against Belgium.
Canada dominated on Thursday; they tested some fresh tactics but, most importantly, turned their attention to the footballing task at hand as they look to take the next step in Canada’s World Cup campaign.
“We know it’s been a difficult week, but we were prepared, and we were ready,” Alistair Johnston said. “We wanted to make a statement.”
Up next:
It may have been three months since Canada last played, but they won’t have to wait as long for their next chance. The squad travels down to Honduras for their second match of the international window. They look to improve to 2-0-0 in Nations League play on June 13 before disbanding until September’s international window. | https://btsvancity.com/2022/06/10/curacaorecap/ | 2022-06-10T13:56:00Z | https://btsvancity.com/2022/06/10/curacaorecap/ | true | 1 |
Photo Credit: Tara Ocean Foundation
Several of the 5,500 marine RNA virus species recently identified by scientists may help push carbon absorbed from the atmosphere to permanent storage on the ocean floor, according to a study. The findings also suggest that a small percentage of the newly discovered species had borrowed genes from the animals they infected, which could aid researchers in determining their supposed hosts and functions in marine processes. The research is leading to a greater understanding of the outsized impact these tiny particles play in the ocean ecosystem, in addition to charting a wealth of core ecological data.
These RNA viruses were discovered in plankton samples gathered by the Tara Oceans Consortium, a global study of the impact of climate change on the ocean conducted onboard the schooner Tara. The effort aims to learn more about the organisms that live in the ocean and do the majority of the work of absorbing half of the human-generated carbon in the atmosphere and producing half of the oxygen we breathe in order to predict how the ocean will respond to climate change.
Though these marine viral species aren't harmful to humans, they act like any other virus, infecting another organism and exploiting its cellular machinery to replicate itself. Though the consequence may always be negative for the host, a virus's actions may have environmental benefits, such as assisting in the dissipation of a hazardous algal bloom.
The findings of the study have been published in the journal Science.
Additional research discovered 1,243 RNA virus species linked to carbon export. In order to promote carbon export to the ocean's depths, 11 species were involved. Two viruses associated to algae as hosts were chosen as the most promising targets for further research.
Ahmed Zayed, a research scientist in microbiology at The Ohio State University and co-first author of the study, said, “The findings are important for model development and predicting what is happening with carbon in the correct direction and at the correct magnitude.”
Another professor, Matthew Sullivan said that as people emitted more carbon into the atmosphere, the researchers relied on the ocean's vast buffering capability to keep climate change at bay.
Sullivan added that they were looking for viruses that could tune to a more digestible carbon, allowing the system to develop, produce larger cells, and eventually sink. And if it sinks, humans will be spared the harshest effects of climate change for another few hundred or thousand years.
To identify possible hosts, the researchers employed a combination of methods, first inferring the host from the viruses' classification in the context of marine plankton, and then generating predictions based on how the virus and host amounts co-vary since their abundances are dependent on one another. The third technique involved looking for signs of RNA virus incorporation in cellular genomes.
While most dsDNA viruses infect bacteria and archaea, which are widespread in the ocean, this recent study discovered that RNA viruses mostly infect fungi and microbial eukaryotes, as well as invertebrates to a lesser level. Only a small percentage of marine RNA viruses are capable of infecting bacteria.
For the latest tech news and reviews, follow Gadgets 360 on Twitter, Facebook, and Google News. For the latest videos on gadgets and tech, subscribe to our YouTube channel. | https://gadgets360.com/science/news/new-research-marine-viruses-help-slow-climate-change-3055061 | 2022-06-10T13:56:49Z | https://gadgets360.com/science/news/new-research-marine-viruses-help-slow-climate-change-3055061 | false | 1 |
Yoga Accessories Market Forecast Report 2021: USD 4.98 Billion Market Growth Opportunity by 2025|Technavio
The yoga accessories market offers a comprehensive analysis by Product (yoga mats, yoga straps, yoga blocks, and others), Distribution Channel (offline and online), and Geography (North America, Europe, APAC, South America, and MEA)
NEW YORK, June 10, 2022 /PRNewswire/ -- The yoga accessories market size is expected to grow by USD 4.98 billion, progressing a CAGR of 6.15% from 2020 to 2025, according to Technavio's latest market report. Growing enrolment in fitness and health clubs is a major trend supporting the yoga accessories market growth in the forecast period. Health and fitness clubs' memberships have witnessed a steady increase over the past decade. Owning to the increasing demand for fitness activities. These clubs are coming up with exclusive packages to attract customers and providing them with yearly or monthly packages with discounts. The number of health clubs in the US increased by more than 18% between 2012 and 2020. This rise in the number of memberships in health and fitness clubs has resulted in a rise in the demand for yoga products, including yoga accessories. Moreover, customers usually prefer health and fitness clubs as these provide proper trainers to help them exercise. Furthermore, the growing number of memberships in fitness and health clubs is driving the demand for yoga accessories. Therefore, the growing focus of people on health and fitness is triggering the growth of health and fitness clubs' brands.
For more highlights on the trends - Download a sample now!
Yoga Accessories Market: Major Growth Drivers
The yoga accessories market report the following factors as major growth drivers during the forecast period:
Product premiumization due to more innovation in yoga accessories
The growing number of yoga practitioners
Wellness initiatives of the government and corporate agencies
To know more about the drivers along with the challenges - Download a sample now!
Yoga Accessories Market: Vendor Analysis
The yoga accessories market is fragmented and the vendors are deploying growth strategies such as portfolio expansion and product innovation to compete in the market. The yoga accessories market report also offers information on several market vendors, including adidas AG, Barefoot Yoga Co., Hugger Mugger Yoga Products LLC Inc., JadeYoga, La Vie Boheme Yoga, Liforme Ltd., lululemon Athletica Inc., Manduka LLC, Sequential Brands Group Inc., and Yoga Direct LLC among others.
adidas AG - The company offers yoga accessories such as ADIDAS by STELLA MCCARTNEY yoga mat, ADIDAS by STELLA MCCARTNEY Training mat, and others.
To know about all major vendor offerings - Download a sample now!
Yoga Accessories Market: Revenue Generating Segment
The yoga mats segment will be significant for revenue generation for the yoga accessories market.
.Yoga mats are specially fabricated to prevent the slippage of feet and hands while performing yoga exercises. These mats also help in keeping the body warm, and the energy generated is retained within the body rather than getting passed on to the floor. The market for yoga mats is expected to grow steadily during the forecast period.
To know about the contribution of each segment - Download a sample now!
The competitive scenario provided in the Yoga Accessories Market report analyzes, evaluates, and positions companies based on various performance indicators. Some of the factors considered for this analysis include the financial performance of companies over the past few years, growth strategies, product innovations, new product launches, investments, growth in market share, etc. Don't wait, Make a strategic approach & boost your business goals with our Yoga Accessories Market Forecast Report - Buy Now!
Reasons to Buy Yoga Accessories Market Report:
CAGR of the market during the forecast period 2021-2025
Detailed information on factors that will assist yoga accessories market growth during the next five years
Estimation of the yoga accessories market size and its contribution to the parent market
Predictions on upcoming trends and changes in consumer behavior
The growth of the yoga accessories market across North America, Europe, APAC, South America, and MEA
Analysis of the market's competitive landscape and detailed information on vendors
Comprehensive details of factors that will challenge the growth of yoga accessories market vendors
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The outdoor gym equipment market share is expected to increase by USD 687.37 million from 2021 to 2026, and the market's growth momentum will accelerate at a CAGR of 6.13%. Download a sample now!
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Table of Content
1 Executive Summary
2 Market Landscape
2.1 Market ecosystem
2.2 Value chain analysis
3 Market Sizing
3.1 Market definition
3.2 Market segment analysis
3.3 Market size 2020
3.4 Market outlook: Forecast for 2020 - 2025
4 Five Forces Analysis
4.1 Five forces summary
4.2 Bargaining power of buyers
4.3 Bargaining power of suppliers
4.4 Threat of new entrants
4.5 Threat of substitutes
4.6 Threat of rivalry
4.7 Market condition
5 Market Segmentation by Product
5.1 Market segments
5.2 Comparison by Product
5.3 Yoga mats - Market size and forecast 2020-2025
5.4 Yoga straps - Market size and forecast 2020-2025
5.5 Yoga blocks - Market size and forecast 2020-2025
5.6 Others - Market size and forecast 2020-2025
5.7 Market opportunity by Product
6 Market Segmentation by Distribution channel
6.1 Market segments
6.2 Comparison by Distribution channel
6.3 Offline - Market size and forecast 2020-2025
6.4 Online - Market size and forecast 2020-2025
6.5 Market opportunity by Distribution channel
7 Customer landscape
8 Geographic Landscape
8.1 Geographic segmentation
8.2 Geographic comparison
8.3 North America - Market size and forecast 2020-2025
8.4 Europe - Market size and forecast 2020-2025
8.5 APAC - Market size and forecast 2020-2025
8.6 South America - Market size and forecast 2020-2025
8.7 MEA - Market size and forecast 2020-2025
8.8 Key leading countries
8.9 Market opportunity by geography
9 Drivers, Challenges, and Trends
9.1 Market drivers
9.2 Market challenges
9.3 Market trends
10 Vendor Landscape
10.1 Overview
10.2 Vendor landscape
10.3 Landscape disruption
11 Vendor Analysis
11.1 Vendors covered
11.2 Market positioning of vendors
11.3 adidas AG
11.4 Barefoot Yoga Co.
11.5 Hugger Mugger Yoga Products LLC Inc.
11.6 JadeYoga
11.7 La Vie Boheme Yoga
11.8 Liforme Ltd.
11.9 lululemon athletica Inc.
11.10 Manduka LLC
11.11 Sequential Brands Group Inc.
11.12 Yoga Direct LLC
12 Appendix
12.1 Scope of the report
12.2 Currency conversion rates for US$
12.3 Research methodology
12.4 List of abbreviations
About Us
Technavio is a leading global technology research and advisory company. Their research and analysis focus on emerging market trends and provide actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavio's report library consists of more than 17,000 reports, covering 800 technologies spanning 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio's comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios.
Contact
Technavio Research
Jesse Maida
Media & Marketing Executive
US: +1 844 364 1100
UK: +44 203 893 3200
Email: media@technavio.com
Website: www.technavio.com/
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SOURCE Technavio | https://finance.yahoo.com/news/yoga-accessories-market-forecast-report-133000728.html | 2022-06-10T13:58:16Z | https://finance.yahoo.com/news/yoga-accessories-market-forecast-report-133000728.html | false | 1 |
PR Newswire
SANTA CLARA, Calif., May 11, 2022
First-gen ZTNA solutions have major gaps in security protection and can put organizations at significant risk
SANTA CLARA, Calif., May 11, 2022 /PRNewswire/ -- Palo Alto Networks (NASDAQ: PANW), the global cybersecurity leader, today urged the industry to move to Zero Trust Network Access 2.0 (ZTNA 2.0) — the foundation for a new era of secure access. ZTNA was developed as a replacement for virtual private networks (VPNs) when it became clear that most VPNs did not adequately scale and were overly permissive, but the first-generation ZTNA products (ZTNA 1.0) are too trusting and can put customers at significant risk. ZTNA 2.0 solves these problems by removing implicit trust to help ensure organizations are properly secured.
"This is a critical time for cybersecurity. We are in an era of unprecedented cyberattacks, and the past two years have dramatically changed work — for many, work is now an activity, not a place. This means that securing employees and the applications they need is both harder and more important," said Nir Zuk, founder and chief technology officer at Palo Alto Networks. "Zero trust has been embraced as the solution — and it is absolutely the right approach! Unfortunately, not every solution with Zero Trust in its name can be trusted. ZTNA 1.0 — for example — falls short."
For modern organizations where hybrid work and distributed applications are the norm, ZTNA 1.0 has several limitations. It is overly permissive in granting access to applications because it can't control access to sub-applications or particular functions. Additionally, there is no monitoring of changes in user, application or device behavior, and it can't detect or prevent malware or lateral movement across connections. ZTNA 1.0 also cannot protect all enterprise data.
ZTNA 2.0-capable products, such as Palo Alto Networks Prisma® Access, help organizations meet the security challenges of modern applications, threats and the hybrid workforce. ZTNA 2.0 incorporates the following key principles:
- Least-privileged access — enables precise access control at the application and sub-application levels, independent of network constructs like IP addresses and port numbers.
- Continuous trust verification — after access to an application is granted, continuous trust assessment is ongoing based on changes in device posture, user behavior and application behavior.
- Continuous security inspection — uses deep and ongoing inspection of all application traffic, even for allowed connections to help prevent threats, including zero-day threats.
- Protection of all data — provides consistent control of data across all applications, including private applications and SaaS applications, with a single data loss prevention (DLP) policy.
- Security for all applications — consistently secures all types of applications used across the enterprise, including modern cloud native applications, legacy private applications and SaaS applications.
In a new report, John Grady, ESG senior analyst, said: "[F]irst-generation/ZTNA 1.0 solutions fall short in many ways on delivering on the promise of true zero trust. In fact, they grant more access than is desired. What's more, once access is granted in ZTNA 1.0 solutions, the connection is implicitly trusted forever, allowing a handy exploit route for sophisticated threats and/or malicious actions and behavior." Grady also said, "It is time to embrace a new approach to ZTNA, one that has been designed from the ground up to meet the specific challenges of modern applications, threats, and a hybrid workforce."
"Securing today's hybrid workforce, with an increase in cloud and mobile technologies and evolving requirements, can be complicated," said Jerry Chapman, engineering fellow, Optiv. "Rethinking Zero Trust is essential for modern, hybrid organizations to prevent threats. Together with Palo Alto Networks, we're advising our customers to incorporate ZTNA 2.0 principles like continuous review of identity and connection across their domains to stay secure."
New Prisma Access Capabilities
Palo Alto Networks Prisma Access is the industry's only solution that meets today's ZTNA 2.0 requirements. Prisma Access protects all application traffic with best-in-class capabilities while securing both access and data.
New additions to Prisma Access announced today add the following capabilities:
- ZTNA connector — simplifies the process of onboarding cloud native and traditional applications into the service, helping make ZTNA 2.0 easier to deploy and more secure.
- The industry's only unified SASE product — providing a common policy framework and data model for all SASE capabilities, managed from a single cloud management console.
- Self-serve autonomous digital experience management (ADEM) — helps proactively notify users of issues that require prompt attention and provides them with guidance on how to remediate.
Availability
Prisma Access is generally available today with full support for ZTNA 2.0. The new ZTNA connector, unified SASE, and self-service ADEM will be available in the next 90 days.
About Palo Alto Networks
Palo Alto Networks, the global cybersecurity leader, is shaping the cloud-centric future with technology that is transforming the way people and organizations operate. Our mission is to be the cybersecurity partner of choice, protecting our digital way of life. We help address the world's greatest security challenges with continuous innovation that seizes the latest breakthroughs in artificial intelligence, analytics, automation, and orchestration. By delivering an integrated platform and empowering a growing ecosystem of partners, we are at the forefront of protecting tens of thousands of organizations across clouds, networks, and mobile devices. Our vision is a world where each day is safer and more secure than the one before. For more information, visit www.paloaltonetworks.com.
Palo Alto Networks, Prisma, and the Palo Alto Networks logo are registered trademarks of Palo Alto Networks, Inc. in the United States and in jurisdictions throughout the world. All other trademarks, trade names, or service marks used or mentioned herein belong to their respective owners.
Forward-Looking Statements
This release contains forward-looking statements that involve risks and uncertainties, including regarding the benefits or potential benefits to customers of our products. These forward-looking statements are not guarantees of future performance, and actual results, developments and business decisions may differ from those envisaged by such forward-looking statements. We identify the principal risks and uncertainties that affect our performance in our Annual Report on Form 10-K, filed on September 3, 2021, and our other filings with the U.S. Securities and Exchange Commission, which are available on our website at investors.paloaltonetworks.com and on the SEC's website at www.sec.gov. All forward-looking statements in this release are based on information available to us as of the date hereof, and we do not assume any obligation to update the forward-looking statements provided to reflect events that occur or circumstances that exist after the date on which they were made.
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SOURCE Palo Alto Networks, Inc. | https://www.gurufocus.com/news/1751997/palo-alto-networks-calls-on-cybersecurity-industry-to-adopt-ztna-20--zero-trust-with-zero-exceptions | 2022-06-10T14:01:22Z | https://www.gurufocus.com/news/1751997/palo-alto-networks-calls-on-cybersecurity-industry-to-adopt-ztna-20--zero-trust-with-zero-exceptions | false | 14 |
Serena Williams's floral Nike Air Force 1 sneaker is a work of art
Serena Williams is nearing 20 years with Nike. Their ties run so deep that the Swoosh recently unveiled its biggest and most sustainable building in the athlete’s honor. Already having a couple of Nike sneakers under her belt, the tennis star’s Design Crew is reimagining another Air Force 1 sneaker that...
www.inputmag.com | https://www.newsbreak.com/news/2629341681667/serena-williams-s-floral-nike-air-force-1-sneaker-is-a-work-of-art | 2022-06-10T14:05:01Z | https://www.newsbreak.com/news/2629341681667/serena-williams-s-floral-nike-air-force-1-sneaker-is-a-work-of-art | true | null |
In celebration of National Iced Tea Day, TAZO and Deepti Vempati will launch the #TAZOSummerBucketList giveaway – offering 2,500 tea lovers the chance to win free TAZO bottled iced tea and 20 fans the chance to win summer prizes.
PURCHASE, N.Y., June 10, 2022 /PRNewswire/ -- According to a recent survey commissioned by TAZO, 72% of Millennials and Gen Z-ers say they want to try something new this summer, but they need a little inspiration to get started. And 70% say they want to try an activity that gets them out of their comfort zone this summer.1
That's why TAZO is teaming up with Deepti Vempati, star of Netflix's hit show, Love Is Blind, to launch the TAZO Summer Bucket List this June 10th—National Iced Tea Day. The #TAZOSummerBucketList includes a wide array of seasonal activities that will inspire people to channel their mood and make the most out of their adventures, allowing for a truly spontaneous summer. With TAZO being the unconventional tea brand that breaks through the ordinary, Deepti – who challenged the status quo to find her unique love story – is the perfect partner for the #TAZOSummerBucketList.
Inspired by TAZO's bottled iced tea blends – PASSION®, a vibrant, herbal infusion of hibiscus, orange peel and cinnamon, ZEN™, an invigorating infusion of green tea, spearmint and lemongrass, AWAKE®, a bold, full bodied blend of smooth black tea and CALM™, a soothing blend of chamomile, lemongrass, hibiscus and spearmint – TAZO and Deepti have created a mood-based bucket list corresponding to each blend that will motivate fans to choose activities based on their mood, live summer to the fullest and get out of their comfort zones.
"I love TAZO iced teas! The bold blends make them the perfect pairing for whatever I'm in the mood to do. My favorite blend is PASSION® because it captures that perfect day-date vibe," said Deepti. "Each day of summer feels like an opportunity to try something new, and I am more ready than ever to check things off my TAZO Summer Bucket List. Whether I'm being a tourist in my own city, visiting a national park or trying a new workout class, I'm excited for unexpected adventures."
"TAZO has a rich history of sourcing premium ingredients from all parts of the world to craft the unique pairings in each of our teas. When you sip one of our bottled iced tea blends, there's no limit to the adventures, ideas and passions it can unlock," said Katrina McDonald, Pepsi Lipton Partnership Senior Marketing Director. "Nearly two-thirds (64%) of Millennials and Gen Z-ers say that when they think about this summer, they're more likely to 'play it by ear' instead of making plans in advance.2 With Deepti's partnership, we're excited for tea lovers to find inspiration in the mood-based bucket lists."
Entering the giveaway is easy. Fans have from June 10-21 to follow @TAZO on Instagram and tag a friend in the comments, sharing which bucket list activity they'd like to try this summer along with the campaign hashtag, #TAZOSummerBucketList, and #sweepstakes. 2,500 TAZO fans will win free TAZO bottled iced teas, and 20 lucky fans will win their choice of an exhilarating summer prize valued at $500, each inspired by our iced tea blends:
- Follow your PASSION® and embark on the experience you've been waiting for – whether it's courtside seats to see your favorite team or front row concert tickets to see your favorite artist.
- Bring some ZEN™ into your home and recreate your space. Whether it's a new coffee table, fresh bedding or cooking supplies, your home will feel refreshed in no time.
- AWAKE® your ambition and prioritize your wellness with access to amazing gyms, fitness studios, salons and spas.
- Unwind and stay CALM™ with some much-needed R&R. Whether it's a staycation or somewhere you've been waiting to visit, sit back, relax and unwind in a vacation home.
For official contest rules and prize details, visit www.TAZOSummerBucketList.com. The TAZO Summer Bucket List Sweepstakes launches on June 10, 2022, at 12pm ET.
TAZO's bottled iced teas are made from 100% recycled plastic and are now available in the refrigerated section of grocery retailers nationwide. TAZO's bottled iced teas are certified USDA Organic, contain no artificial colors or sweeteners, and are available in two sizes: single serve, 12oz. bottles (SRP $1.99), and multi-serve, 42oz. bottles (SRP $3.79). For more information, please visit www.TAZO.com.
Research Methodology
The TAZO survey was conducted by Edelman Data & Intelligence among 1,000 nationally representative US adults ages 18-40, between April 27th and May 2nd, 2022, using an email invitation and an online survey.
About PepsiCo
PepsiCo products are enjoyed by consumers more than one billion times a day in more than 200 countries and territories around the world. PepsiCo generated more than $79 billion in net revenue in 2021, driven by a complementary beverage and convenient foods portfolio that includes Lay's, Doritos, Cheetos, Gatorade, Pepsi-Cola, Mountain Dew, Quaker, and SodaStream. PepsiCo's product portfolio includes a wide range of enjoyable foods and beverages, including many iconic brands that generate more than $1 billion each in estimated annual retail sales.
Guiding PepsiCo is our vision to Be the Global Leader in Beverages and Convenient Foods by Winning with PepsiCo Positive (pep+). pep+ is our strategic end-to-end transformation that puts sustainability at the center of how we will create value and growth by operating within planetary boundaries and inspiring positive change for planet and people. For more information, visit www.pepsico.com.
About Unilever North America
Unilever is one of the world's leading suppliers of Beauty & Personal Care, Home Care, and Foods & Refreshment products, with sales in over 190 countries and products used by 2.5 billion people every day. We have 149,000 employees and generated sales of €50.7 billion in 2020. Over half of our footprint is in developing and emerging markets. We have around 400 brands found in homes all over the world. In the United States and Canada, the portfolio includes iconic brand such as: Dove, Knorr, Hellmann's, Lipton, Magnum, Axe, Ben & Jerry's, Degree, Dollar Shave Club, Q-tips, Seventh Generation, St. Ives, Suave, TRESemmé, and Vaseline.
Our vision is to be the global leader in sustainable business and to demonstrate how our purpose-led, future-fit business model drives superior performance. We have a long tradition of being a progressive, responsible business. It goes back to the days of our founder William Lever, who launched the world's first purposeful brand, Sunlight Soap, more than 100 years ago, and it's at the heart of how we run our company today.
The Unilever Compass, our sustainable business strategy, is set out to help us deliver superior performance and drive sustainable and responsible growth, while:
- improving the health of the planet;
- improving people's health, confidence and wellbeing; and
- contributing to a fairer and more socially inclusive world.
While there is still more to do, we are proud to have been recognized in 2020 as a sector leader in the Dow Jones Sustainability Index and – for the tenth-consecutive year – as the top ranked company in the 2020 GlobeScan/SustainAbility Sustainability Leaders survey.
For more information on Unilever U.S. and its brands visit: www.unileverusa.com
For more information on Unilever Canada and its brands visit: www.unilever.ca
About ekaterra
ekaterra is the leading global Tea business, with world-class purpose-driven brands including Lipton, PG tips, Pukka, T2 and TAZO®. With 11 production factories in 4 continents and Tea estates in 3 countries, ekaterra is growing a world of wellbeing through the regenerative power of plants. https://ekaterratea.com/
1 The TAZO survey was conducted by Edelman Data & Intelligence among 1,000 nationally representative US adults ages 18-40, between April 27th and May 2nd, 2022, using an email invitation and an online survey.
2 The TAZO survey was conducted by Edelman Data & Intelligence among 1,000 nationally representative US adults ages 18-40, between April 27th and May 2nd, 2022, using an email invitation and an online survey.
Contact: Alison Meade, PepsiCo
Alison.Meade@pepsico.com
Lauren Mandikas, Edelman
Lauren.Mandikas@edelman.com
View original content to download multimedia:
SOURCE PepsiCo | https://www.keyc.com/prnewswire/2022/06/10/tazo-iced-tea-deepti-vempati-team-up-launch-summer-bucket-list-spontaneous-adventures-every-mood-featuring-iced-tea-giveaway-exciting-summer-prizes/ | 2022-06-10T14:08:17Z | https://www.keyc.com/prnewswire/2022/06/10/tazo-iced-tea-deepti-vempati-team-up-launch-summer-bucket-list-spontaneous-adventures-every-mood-featuring-iced-tea-giveaway-exciting-summer-prizes/ | false | 12 |
US lifts COVID-19 test requirement for international travel
WASHINGTON (AP) — The Biden administration is lifting its requirement that international air travelers to the U.S. take a COVID-19 test within a day before boarding their flights, easing one of the last remaining government mandates meant to contain the spread of the coronavirus.
A senior administration official said the mandate expires Sunday at 12:01 a.m. EDT, saying the Centers for Disease Control and Prevention has determined that it’s no longer necessary. The official, speaking Friday on the condition of anonymity to preview the formal announcement, said that the agency would reevaluate the need for the testing requirement every 90 days and that it could be reinstated if a troubling new variant emerges.
The Biden administration put in place the testing requirement last year, as it moved away from restrictions that banned nonessential travel from several dozen countries — most of Europe, China, Brazil, South Africa, India and Iran — and instead focuses on classifying individuals by the risk they pose to others. It came in conjunction with a requirement that foreign, non-immigrant adults traveling to the United States need to be fully vaccinated, with only limited exceptions.
The initial mandate allowed those who were fully vaccinated to show proof of a negative test within three days of travel, while unvaccinated people had to present a test taken within one day of travel.
In November, as the highly transmissible omicron variant swept the world, the Biden administration toughened the requirement and required all travelers, regardless of vaccination status, to test within a day of travel to the U.S.
Airline and tourism groups have been pressing the administration for months, pushing to eliminate the testing requirement, saying it is discouraging people from booking international trips. Many other countries have lifted their testing requirements for fully vaccinated and boosted travelers in a bit to increase tourism.
In February, the groups argued the testing requirement was obsolete because of the high number of omicron cases already in every state, higher vaccination rates and new treatments for the virus.
Copyright 2022 The Associated Press. All rights reserved. | https://www.kltv.com/2022/06/10/us-lifts-covid-19-test-requirement-international-travel/ | 2022-06-10T14:08:59Z | https://www.kltv.com/2022/06/10/us-lifts-covid-19-test-requirement-international-travel/ | false | 24 |
Budget 2023: Air travel, vehicles, shopping on debit cards to get expensive
All eyes are set on the fiscal budget for the year 2022-2023 that is being presented today (Friday) in Parliament. The new budget, which has reportedly been prepared under the influence to meet the requirement of the International Monetary Fund (IMF), includes the tax revenue target of Rs7,200 billion.
Here is the list of things which are expected to become expensive as the government is looking to increase taxes and impose new ones.
-
4 to 7 per cent super taxes is likely to be imposed on commercial banking.
-
Buying products online from outside the country using credit and debit cards might get more expensive as additional taxes are likely to be imposed.
-
Increase of Rs40,000 has been proposed on business class air tickets.
-
Luxury vehicles to get more expensive as 1 per cent withholding tax is likely to be imposed on filers while 2 per cent for non-filers.
-
Property rate and real estate sector to see a price increase
-
The government may increase the tax net by expanding point-of-sale system in major cities.
-
Rs5 per unit subsidy might be withdrawn on electricity
The government is expected to facilitate the import of raw materials for export and abolish sales tax on subsidies for power consumers.
In the outgoing year, Gross Product (GDP) has exceeded the target of 4.8% and has been recorded at 5.97%, posting growth in agriculture, industries, and services sectors.
The agricultural sector registered 4.4% growth against the target of 3.5%, while the industrial sector posted 7.2% growth against the target of 6.6%. Services sector recorded6.2% growth against the target set at 4.2%.
However, in the outgoing fiscal year, inflation stood at 11.1% against an 8% target while the trade deficit rose to $45 billion.
The balance of payment crisis spurred by the current account deficit “dampened” the effect of higher growth in fiscal years 2021-22, said the Pakistan Economic Survey, released on Thursday. | https://www.samaaenglish.tv/news/40010399/budget-2023-air-travel-vehicles-shopping-on-debit-cards-to-get-expensive | 2022-06-10T14:09:11Z | https://www.samaaenglish.tv/news/40010399/budget-2023-air-travel-vehicles-shopping-on-debit-cards-to-get-expensive | true | 1 |
(NEXSTAR) – Monkeypox may be the newest global outbreak concern, but the virus itself is nothing new. It was first discovered over 50 years ago in a group of captive primates – hence the name “monkeypox.”
The virus has some more scientific name designations; it Orthopoxvirus genus in the family Poxviridae, according to the World Health Organization.
In 1958 there were two outbreaks of the virus in monkey colonies that were being researched, according to the Centers for Disease Control and Prevention. It wasn’t until 1970 that the first human case of monkeypox was discovered in the Democratic Republic of the Congo, writes the CDC.
Even though the virus has been around a long time, it has not been eradicated. Because animals continue to harbor the virus, it is endemic in several parts of Africa.
Since the 1970s most human cases have been in central and west Africa and outbreaks have been relatively limited. The WHO estimates there are thousands of monkeypox infections in about a dozen African countries every year. Most are in Congo, which reports about 6,000 cases annually, and Nigeria, with about 3,000 cases a year.
Then, in 2022, the virus started to spread in Europe and now in the United States. Forty cases have been confirmed in 14 states and Washington, D.C., according to CDC data on Thursday.
Another cluster of U.S. cases happened back in 2003, when 47 people in six states had confirmed or probable cases. They caught the virus from pet prairie dogs that been housed near imported small mammals from Ghana.
Most monkeypox patients experience only fever, body aches, chills and fatigue. People with more serious illness may develop a rash and lesions on the face and hands that can spread to other parts of the body.
Most people recover within about two to four weeks without needing to be hospitalized, monkeypox can be fatal for up to 6% of cases and is thought to be more severe in children.
The Associated Press contributed to this report. | https://www.khon2.com/news/national/where-did-the-monkeypox-virus-get-its-name/ | 2022-06-10T14:09:15Z | https://www.khon2.com/news/national/where-did-the-monkeypox-virus-get-its-name/ | true | 19 |
Residents were left dazed and confused at the sight of a unidentified flying object zipping across the night sky. At around the same time, plane spotters reported that multiple aircraft had been prevented from landing at East Midlands Airport on Thursday evening.
The UFO - which sported flashing coloured lights - was filmed in the sky from a residential street in Long Eaton, reports DerbyshireLive.
The small flying object was hovering and had flashing red and green lights. Witnesses were unable to determine the nature of the craft in low light as they watched.
In video footage provided to Derbyshire Live, the object is seen hovering in the sky and filmed from South Street in Long Eaton. One onlooker remarked "we might be on X-Files" as they filmed the craft for almost five minutes.
READ MORE Martin Lewis fan's five minute check to save £288 on car insurance
Bill Pearce, who took the video, said: "When I got home from a pool match, my neighbour was outside waving at something in the sky.
"Initially I looked out and I thought, what is that? Because it was changing colours and what have you. Some years ago, I saw a white light in the sky and it shot over to one side and stopped then did it again to another and then it just shot off and it wasn't a plane but I never saw anything in the news about it.
"People seemed to think that it is a drone when I put the video on Facebook and some comments have said it was a plane but it's not a plane because it didn't make any noise.
"I think there were some issues that caused aborted landings at East Midlands Airport last night so they may be linked."
According to Flight Radar, several planes had delayed landings at East Midlands Airport on the night of Thursday, June 9 and in the early hours of this morning, Friday, June 10. The flight path of the aircraft shows that some were left circling the airspace above Leicestershire before being cleared to land.
East Midlands Airport Spotters have theorised that the craft was in fact a drone from the nearby Download Festival. Thousands of music fans are arriving at Donington Park for the UK's largest rock festival which is taking place this weekend, starting today and lasting till Sunday. They speculated that a fan might've launched a drone.
East Midlands Airport has been asked whether the two incidents were linked. | https://www.leicestermercury.co.uk/news/uk-world-news/ufo-caught-camera-east-midlands-7192477 | 2022-06-10T14:09:23Z | https://www.leicestermercury.co.uk/news/uk-world-news/ufo-caught-camera-east-midlands-7192477 | false | 1 |
Flaharty Asset Management LLC purchased a new position in shares of Old Dominion Freight Line, Inc. (NASDAQ:ODFL – Get Rating) in the fourth quarter, according to the company in its most recent 13F filing with the Securities and Exchange Commission (SEC). The firm purchased 660 shares of the transportation company’s stock, valued at approximately $237,000.
Other large investors have also recently bought and sold shares of the company. CVA Family Office LLC acquired a new stake in shares of Old Dominion Freight Line in the fourth quarter valued at approximately $29,000. Carroll Financial Associates Inc. bought a new stake in Old Dominion Freight Line in the 4th quarter valued at $29,000. Ancora Advisors LLC bought a new stake in Old Dominion Freight Line in the 3rd quarter valued at $29,000. Pittenger & Anderson Inc. bought a new stake in Old Dominion Freight Line during the 4th quarter worth about $37,000. Finally, Manchester Capital Management LLC bought a new stake in Old Dominion Freight Line during the 4th quarter worth about $40,000. Institutional investors own 77.86% of the company’s stock.
Several research analysts have recently weighed in on the stock. Citigroup lowered their price objective on shares of Old Dominion Freight Line from $295.00 to $265.00 and set a “neutral” rating on the stock in a research note on Thursday, May 19th. Morgan Stanley upped their price target on shares of Old Dominion Freight Line from $335.00 to $337.00 and gave the company an “equal weight” rating in a research report on Monday, April 4th. Wells Fargo & Company increased their price objective on shares of Old Dominion Freight Line from $255.00 to $280.00 in a research report on Thursday, April 28th. Zacks Investment Research upgraded shares of Old Dominion Freight Line from a “hold” rating to a “buy” rating and set a $324.00 price objective for the company in a research report on Monday, March 14th. Finally, Susquehanna Bancshares raised their price target on shares of Old Dominion Freight Line from $275.00 to $285.00 in a report on Thursday, April 28th. One analyst has rated the stock with a sell rating, fourteen have assigned a hold rating and four have issued a buy rating to the stock. According to data from MarketBeat.com, the company presently has an average rating of “Hold” and an average price target of $299.17.
Old Dominion Freight Line (NASDAQ:ODFL – Get Rating) last announced its earnings results on Wednesday, April 27th. The transportation company reported $2.60 earnings per share (EPS) for the quarter, beating the consensus estimate of $2.37 by $0.23. Old Dominion Freight Line had a net margin of 20.17% and a return on equity of 32.41%. The business had revenue of $1.50 billion during the quarter, compared to analyst estimates of $1.46 billion. During the same period in the previous year, the business posted $1.70 earnings per share. Old Dominion Freight Line’s revenue for the quarter was up 32.9% on a year-over-year basis. On average, equities analysts forecast that Old Dominion Freight Line, Inc. will post 11.48 earnings per share for the current fiscal year.
The firm also recently disclosed a quarterly dividend, which will be paid on Wednesday, June 15th. Stockholders of record on Wednesday, June 1st will be issued a $0.30 dividend. The ex-dividend date is Tuesday, May 31st. This represents a $1.20 dividend on an annualized basis and a dividend yield of 0.48%. Old Dominion Freight Line’s payout ratio is 12.26%.
Old Dominion Freight Line Company Profile (Get Rating)
Old Dominion Freight Line, Inc operates as a less-than-truckload (LTL) motor carrier in the United States and North America. It provides regional, inter-regional, and national LTL services, including expedited transportation. The company also offers various value-added services, such as container drayage, truckload brokerage, and supply chain consulting.
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Receive News & Ratings for Old Dominion Freight Line Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Old Dominion Freight Line and related companies with MarketBeat.com's FREE daily email newsletter. | https://www.wkrb13.com/2022/06/10/flaharty-asset-management-llc-buys-new-shares-in-old-dominion-freight-line-inc-nasdaqodfl.html | 2022-06-10T14:10:48Z | https://www.wkrb13.com/2022/06/10/flaharty-asset-management-llc-buys-new-shares-in-old-dominion-freight-line-inc-nasdaqodfl.html | true | 3 |
You need to enable JavaScript to run this app. | https://sportspyder.com/nfl/new-england-patriots/articles/39755528 | 2022-06-10T14:11:31Z | https://sportspyder.com/nfl/new-england-patriots/articles/39755528 | false | null |
People reported seeing an unidentified flying object in the skies amid disruption at East Midlands Airport. Left confused by what they saw, witnesses said the 'UFO' had flashing coloured lights.
Derbyshire Live reports it was filmed in Long Eaton, with the object hovering with red and green lights. But they people in the town were not able to determine the exact nature of the craft in low light as they watched.
But around the same time, plane spotter said that multiple aircraft had been prevented from landing at East Midlands Airport on Thursday night (June 9). East Midlands Airport spotters have theorised that the craft was in fact a drone from the nearby Download Festival.
Read more: Download Festival updates and travel news as thousands arrive for event
Thousands of music fans have been arriving at Donington Park for the UK's largest rock festival which is taking place this weekend, starting today and lasting till Sunday. It was suggested a fan may have launched a drone.
In video footage provided to Derbyshire Live, the object was seen hovering in the sky and filmed from South Street in Long Eaton. One onlooker was heard saying "we might be on X-Files" as they filmed the craft for almost five minutes.
Bill Pearce, who took the video, said: "When I got home from a pool match, my neighbour was outside waving at something in the sky. Initially I looked out and I thought, what is that? Because it was changing colours and what have you. Some years ago, I saw a white light in the sky and it shot over to one side and stopped then did it again to another and then it just shot off and it wasn't a plane but I never saw anything in the news about it.
"People seemed to think that it is a drone when I put the video on Facebook and some comments have said it was a plane but it's not a plane because it didn't make any noise. I think there were some issues that caused aborted landings at East Midlands Airport last night so they may be linked."
According to Flight Radar, several planes had delayed landings at East Midlands Airport on the night of Thursday, June 9, and in the early hours of this morning, Friday, June 10. The flight path of the aircraft shows that some were left circling the airspace above Leicestershire before being cleared to land. Officials at East Midlands Airport were whether the two incidents were linked. | https://www.nottinghampost.com/news/local-news/ufo-spotted-over-skies-flights-7192447 | 2022-06-10T14:15:16Z | https://www.nottinghampost.com/news/local-news/ufo-spotted-over-skies-flights-7192447 | false | 1 |
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