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PMC10000584 | Bhuvana Plakkot,Ashley Di Agostino,Madhan Subramanian | Implications of Hypothalamic Neural Stem Cells on Aging and Obesity-Associated Cardiovascular Diseases | 28-02-2023 | aging,cardiovascular conditions,hypothalamus,neural stem cells,neuroinflammation,obesity | The hypothalamus, one of the major regulatory centers in the brain, controls various homeostatic processes, and hypothalamic neural stem cells (htNSCs) have been observed to interfere with hypothalamic mechanisms regulating aging. NSCs play a pivotal role in the repair and regeneration of brain cells during neurodegene... | Implications of Hypothalamic Neural Stem Cells on Aging and Obesity-Associated Cardiovascular Diseases
The hypothalamus, one of the major regulatory centers in the brain, controls various homeostatic processes, and hypothalamic neural stem cells (htNSCs) have been observed to interfere with hypothalamic mechanisms reg... | |
PMC10000590 | Lesly J. Bueno-Urquiza,Marcela G. Martínez-Barajas,Carlos E. Villegas-Mercado,Jonathan R. García-Bernal,Ana L. Pereira-Suárez,Maribel Aguilar-Medina,Mercedes Bermúdez | The Two Faces of Immune-Related lncRNAs in Head and Neck Squamous Cell Carcinoma | 24-02-2023 | HNSCC,tumor microenvironment,LncRNAs,cancer-associated fibroblasts | Head and neck squamous cell carcinoma (HNSCC) is a group of cancers originating from the mucosal epithelium in the oral cavity, larynx, oropharynx, nasopharynx, and hypopharynx. Molecular factors can be key in the diagnosis, prognosis, and treatment of HNSCC patients. Long non-coding RNAs (lncRNAs) are molecular regula... | The Two Faces of Immune-Related lncRNAs in Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma (HNSCC) is a group of cancers originating from the mucosal epithelium in the oral cavity, larynx, oropharynx, nasopharynx, and hypopharynx. Molecular factors can be key in the diagnosis, prognosis, an... | |
PMC10000595 | Alessia Garufi,Valerio D’Orazi,Giuseppa Pistritto,Mara Cirone,Gabriella D’Orazi | HIPK2 in Angiogenesis: A Promising Biomarker in Cancer Progression and in Angiogenic Diseases | 02-03-2023 | VEGF,HIF-1,hypoxia,micro-RNA,circular HIPK2,p53,cancer,diabetes,diabetic retinopathy,wound healing | Simple Summary Dysregulated angiogenesis contributes to cancer progression and to many chronic inflammatory diseases. Many efforts in the field of angiogenesis have been made to discover new potential molecular targets to be used as biomarkers or to improve the anti-angiogenic therapies. HIPK2, an oncosuppressor able t... | HIPK2 in Angiogenesis: A Promising Biomarker in Cancer Progression and in Angiogenic Diseases
Dysregulated angiogenesis contributes to cancer progression and to many chronic inflammatory diseases. Many efforts in the field of angiogenesis have been made to discover new potential molecular targets to be used as biomark... | |
PMC10000606 | Prajish Iyer,Lili Wang | Emerging Therapies in CLL in the Era of Precision Medicine | 03-03-2023 | CLL,emerging therapies,metabolism,splicing,whole-exome,transcriptome | Simple Summary Despite being a slow-proliferating disease, chronic lymphocytic leukemia (CLL) is an incurable and frequently reoccurring adult leukemia. Although large-scale genome-wide next-generation sequencing studies have provided insights into CLL’s transcriptome and mutational landscape, the molecular mechanisms ... | Emerging Therapies in CLL in the Era of Precision Medicine
Despite being a slow-proliferating disease, chronic lymphocytic leukemia (CLL) is an incurable and frequently reoccurring adult leukemia. Although large-scale genome-wide next-generation sequencing studies have provided insights into CLL’s transcriptome and mu... | |
PMC10000620 | Ioana-Miruna Stanciu,Andreea Ioana Parosanu,Cristina Orlov-Slavu,Ion Cristian Iaciu,Ana Maria Popa,Cristina Mihaela Olaru,Cristina Florina Pirlog,Radu Constantin Vrabie,Cornelia Nitipir | Mechanisms of Resistance to CDK4/6 Inhibitors and Predictive Biomarkers of Response in HR+/HER2-Metastatic Breast Cancer—A Review of the Literature | 05-03-2023 | CDK4/6 inhibitors,advanced/metastatic breast cancer,biomarkers of response,progression on CDK4/6 inhibitors,resistance mechanisms,endocrine therapy | The latest and newest discoveries for advanced and metastatic hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancer are the three cyclin-dependent kinases 4 and 6 inhibitors (CDK4/6i) in association with endocrine therapy (ET). However, even if this treatment revolu... | Mechanisms of Resistance to CDK4/6 Inhibitors and Predictive Biomarkers of Response in HR+/HER2-Metastatic Breast Cancer—A Review of the Literature
The latest and newest discoveries for advanced and metastatic hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancer a... | |
PMC10000625 | Kathryn J. Brayer,Huining Kang,Adel K. El-Naggar,Simon Andreasen,Preben Homøe,Katalin Kiss,Lauge Mikkelsen,Steffen Heegaard,Daniel Pelaez,Acadia Moeyersoms,David T. Tse,Yan Guo,David Y. Lee,Scott A. Ness | Dominant Gene Expression Profiles Define Adenoid Cystic Carcinoma (ACC) from Different Tissues: Validation of a Gene Signature Classifier for Poor Survival in Salivary Gland ACC | 22-02-2023 | oral cancer,biomarker,MYB oncogene,transcriptome analysis,bioinformatics,survival analysis | Simple Summary Adenoid cystic carcinoma (ACC) is a pathologically distinctive tumor that most often occurs in major or minor salivary glands, but can also occur in other tissues. We compared the gene expression profiles of ACC tumor samples from salivary gland, lacrimal gland, breast or skin. Despite their different ti... | Dominant Gene Expression Profiles Define Adenoid Cystic Carcinoma (ACC) from Different Tissues: Validation of a Gene Signature Classifier for Poor Survival in Salivary Gland ACC
Adenoid cystic carcinoma (ACC) is a pathologically distinctive tumor that most often occurs in major or minor salivary glands, but can also o... | |
PMC10000627 | Irène Tatischeff | Extracellular Vesicle-DNA: The Next Liquid Biopsy Biomarker for Early Cancer Diagnosis? | 24-02-2023 | extracellular vesicles (EVs),exosomes (EXs),liquid biopsy (LB),EV-associated DNA (EV-DNA),cancer diagnosis | Simple Summary Each human cancer is a specific disease, but all cancers share the necessity of an early diagnosis for providing the optimal outcome for the patient. Liquid biopsy in blood, as a substitute to invasive tissue biopsies, brought the first important breakthrough for cancer diagnosis. The race for efficient ... | Extracellular Vesicle-DNA: The Next Liquid Biopsy Biomarker for Early Cancer Diagnosis?
Each human cancer is a specific disease, but all cancers share the necessity of an early diagnosis for providing the optimal outcome for the patient. Liquid biopsy in blood, as a substitute to invasive tissue biopsies, brought the ... | |
PMC10000641 | Verena Damiani,Erika Pizzinato,Ilaria Cicalini,Gianmaria Demattia,Mirco Zucchelli,Luca Natale,Claudia Palmarini,Claudia Di Marzio,Luca Federici,Vincenzo De Laurenzi,Damiana Pieragostino | Development of a Method for Detection of SARS-CoV-2 Nucleocapsid Antibodies on Dried Blood Spot by DELFIA Immunoassay | 27-02-2023 | SARS-CoV-2,nucleocapsid antibodies,ELISA,DELFIA,dried blood spot | Antibodies against the SARS-CoV-2 nucleocapsid protein are produced by the immune system in response to SARS-CoV-2 infection, but most available vaccines developed to fight the pandemic spread target the SARS-CoV-2 spike protein. The aim of this study was to improve the detection of antibodies against the SARS-CoV-2 nu... | Development of a Method for Detection of SARS-CoV-2 Nucleocapsid Antibodies on Dried Blood Spot by DELFIA Immunoassay
Antibodies against the SARS-CoV-2 nucleocapsid protein are produced by the immune system in response to SARS-CoV-2 infection, but most available vaccines developed to fight the pandemic spread target t... | |
PMC10000648 | Manjula P. Mony,Kelly A. Harmon,Ryan Hess,Amir H. Dorafshar,Sasha H. Shafikhani | An Updated Review of Hypertrophic Scarring | 21-02-2023 | normal (acute) wound healing,hypertrophic scar,keloids,animal models,treatments | Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with excessive deposition of extracellular matrix and connective tissue at the site of injury. In this review article, we provide an overview of normal (acute) wound healing phases (hemostasis, inflammation, proliferation, and remodelin... | An Updated Review of Hypertrophic Scarring
Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with excessive deposition of extracellular matrix and connective tissue at the site of injury. In this review article, we provide an overview of normal (acute) wound healing phases (hemostasis... | |
PMC10000650 | Márcia C. Coelho,Francisco Xavier Malcata,Célia C. G. Silva | Distinct Bacterial Communities in São Jorge Cheese with Protected Designation of Origin (PDO) | 26-02-2023 | cheese,microbiota,lactic acid bacteria,Leuconostoc,fermented foods,metagenomic analysis,bacterial diversity,high throughput sequencing | São Jorge cheese is an iconic product of the Azores, produced from raw cow’s milk and natural whey starter (NWS). Although it is produced according to Protected Designation of Origin (PDO) specifications, the granting of the PDO label depends crucially on sensory evaluation by trained tasters. The aim of this work was ... | Distinct Bacterial Communities in São Jorge Cheese with Protected Designation of Origin (PDO)
São Jorge cheese is an iconic product of the Azores, produced from raw cow’s milk and natural whey starter (NWS). Although it is produced according to Protected Designation of Origin (PDO) specifications, the granting of the ... | |
PMC10000660 | Micael F. M. Gonçalves,Teresa Pina-Vaz,Ângela Rita Fernandes,Isabel M. Miranda,Carlos Martins Silva,Acácio Gonçalves Rodrigues,Carmen Lisboa | Microbiota of Urine, Glans and Prostate Biopsies in Patients with Prostate Cancer Reveals a Dysbiosis in the Genitourinary System | 23-02-2023 | prostate cancer,microbiota,urinary tract,glans penis,urine | Simple Summary Prostate cancer (PCa) is the most common cancer diagnosed among men aged 50 years and older. There is gaining interest in the genitourinary microbiome in developing ways to control this disease. In this work, an analysis of the bacterial microbiota was performed from urine samples, glans secretions, and ... | Microbiota of Urine, Glans and Prostate Biopsies in Patients with Prostate Cancer Reveals a Dysbiosis in the Genitourinary System
Prostate cancer (PCa) is the most common cancer diagnosed among men aged 50 years and older. There is gaining interest in the genitourinary microbiome in developing ways to control this dis... | |
PMC10000663 | Athanasios Armakolas,Maria Kotsari,John Koskinas | Liquid Biopsies, Novel Approaches and Future Directions | 03-03-2023 | cancer,diagnosis,prognosis,CTCs,ctDNA,miRNA,proteome,exosomes,clinical applications | Simple Summary The gold standard for detecting cancer and profiling tumors is tissue biopsies. Despite this, tissue biopsies have been associated with many limitations leading to the desire for less invasive and more accurate solutions. One very attractive candidate for the diagnosis and prognosis of cancer in patients... | Liquid Biopsies, Novel Approaches and Future Directions
The gold standard for detecting cancer and profiling tumors is tissue biopsies. Despite this, tissue biopsies have been associated with many limitations leading to the desire for less invasive and more accurate solutions. One very attractive candidate for the dia... | |
PMC10000674 | Georgios-Ioannis Verras,Levan Tchabashvili,David-Dimitris Chlorogiannis,Francesk Mulita,Maria-Ioanna Argentou | Updated Clinical Evidence on the Role of Adipokines and Breast Cancer: A Review | 03-03-2023 | breast cancer,adipokines,adiponectine,leptin,resistin,visfatin | Simple Summary Breast cancer is currently one of the most common types of cancer and the number one cause of cancer-related deaths in women worldwide. Despite significant advances involving cancer research in cancer biology, targeted treatments, and novel surgical approaches, breast cancer poses a constant, prominent c... | Updated Clinical Evidence on the Role of Adipokines and Breast Cancer: A Review
Breast cancer is currently one of the most common types of cancer and the number one cause of cancer-related deaths in women worldwide. Despite significant advances involving cancer research in cancer biology, targeted treatments, and nove... | |
PMC10000676 | Vladimir N. Binhi | Statistical Amplification of the Effects of Weak Magnetic Fields in Cellular Translation | 24-02-2023 | biological effect of magnetic field,ribosome,protein translation,incorporation error,the RPM,geomagnetic field | We assume that the enzymatic processes of recognition of amino acids and their addition to the synthesized molecule in cellular translation include the formation of intermediate pairs of radicals with spin-correlated electrons. The mathematical model presented describes the changes in the probability of incorrectly syn... | Statistical Amplification of the Effects of Weak Magnetic Fields in Cellular Translation
We assume that the enzymatic processes of recognition of amino acids and their addition to the synthesized molecule in cellular translation include the formation of intermediate pairs of radicals with spin-correlated electrons. Th... | |
PMC10000678 | Konstantinos Arvanitakis,Ioannis Mitroulis,Antonios Chatzigeorgiou,Ioannis Elefsiniotis,Georgios Germanidis | The Liver Cancer Immune Microenvironment: Emerging Concepts for Myeloid Cell Profiling with Diagnostic and Therapeutic Implications | 28-02-2023 | The Liver Cancer Immune Microenvironment: Emerging Concepts for Myeloid Cell Profiling with Diagnostic and Therapeutic Implications
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. To date, systemic treatment for patients with unresectable or advanced disease was composed... | |||
PMC10000680 | Jihui Lee,Hara Kang | Nucleolin Regulates Pulmonary Artery Smooth Muscle Cell Proliferation under Hypoxia by Modulating miRNA Expression | 06-03-2023 | pulmonary artery smooth muscle cells,nucleolin,hypoxia,microRNA | Hypoxia induces the abnormal proliferation of vascular smooth muscle cells (VSMCs), resulting in the pathogenesis of various vascular diseases. RNA-binding proteins (RBPs) are involved in a wide range of biological processes, including cell proliferation and responses to hypoxia. In this study, we observed that the RBP... | Nucleolin Regulates Pulmonary Artery Smooth Muscle Cell Proliferation under Hypoxia by Modulating miRNA Expression
Hypoxia induces the abnormal proliferation of vascular smooth muscle cells (VSMCs), resulting in the pathogenesis of various vascular diseases. RNA-binding proteins (RBPs) are involved in a wide range of ... | |
PMC10000683 | Elio López-García,Antonio Benítez-Cabello,Javier Ramiro-García,Victor Ladero,Francisco Noé Arroyo-López | In Silico Evidence of the Multifunctional Features of Lactiplantibacillus pentosus LPG1, a Natural Fermenting Agent Isolated from Table Olive Biofilms | 22-02-2023 | probiotic,starter culture,genome overview,fermented vegetables,whole-genome sequencing | In recent years, there has been a growing interest in obtaining probiotic bacteria from plant origins. This is the case of Lactiplantibacillus pentosus LPG1, a lactic acid bacterial strain isolated from table olive biofilms with proven multifunctional features. In this work, we have sequenced and closed the complete ge... | In Silico Evidence of the Multifunctional Features of Lactiplantibacillus pentosus LPG1, a Natural Fermenting Agent Isolated from Table Olive Biofilms
In recent years, there has been a growing interest in obtaining probiotic bacteria from plant origins. This is the case of Lactiplantibacillus pentosus LPG1, a lactic a... | |
PMC10000689 | Aviral Kumar,Sosmitha Girisa,Mohammed S. Alqahtani,Mohamed Abbas,Mangala Hegde,Gautam Sethi,Ajaikumar B. Kunnumakkara | Targeting Autophagy Using Long Non-Coding RNAs (LncRNAs): New Landscapes in the Arena of Cancer Therapeutics | 06-03-2023 | lncRNAs,autophagy,cancer,therapeutics | Cancer has become a global health hazard accounting for 10 million deaths in the year 2020. Although different treatment approaches have increased patient overall survival, treatment for advanced stages still suffers from poor clinical outcomes. The ever-increasing prevalence of cancer has led to a reanalysis of cellul... | Targeting Autophagy Using Long Non-Coding RNAs (LncRNAs): New Landscapes in the Arena of Cancer Therapeutics
Cancer has become a global health hazard accounting for 10 million deaths in the year 2020. Although different treatment approaches have increased patient overall survival, treatment for advanced stages still s... | |
PMC10000693 | Nikita Choudhary,Robert C. Osorio,Jun Y. Oh,Manish K. Aghi | Metabolic Barriers to Glioblastoma Immunotherapy | 28-02-2023 | glioblastoma,immunotherapy,metabolism,tumor microenvironment,glycolysis,glutamine metabolism,lipid metabolism,tryptophan metabolism | Simple Summary Glioblastoma (GBM) is an aggressive brain tumor with limited prognosis despite multimodal treatment approaches. Various immunotherapies have been investigated to address the need for novel therapeutic options in GBM with limited success. Recently, alterations in the metabolism of cancer cells which allow... | Metabolic Barriers to Glioblastoma Immunotherapy
Glioblastoma (GBM) is an aggressive brain tumor with limited prognosis despite multimodal treatment approaches. Various immunotherapies have been investigated to address the need for novel therapeutic options in GBM with limited success. Recently, alterations in the met... | |
PMC10000695 | Cindy Barba,H. Atakan Ekiz,William Weihao Tang,Arevik Ghazaryan,Mason Hansen,Soh-Hyun Lee,Warren Peter Voth,Ryan Michael O’Connell | Interferon Gamma-Inducible NAMPT in Melanoma Cells Serves as a Mechanism of Resistance to Enhance Tumor Growth | 23-02-2023 | melanoma,NAMPT,interferon gamma | Simple Summary The tumor microenvironment is complex, with interacting immune and tumor cells. Immune cells release inflammatory cytokines, including interferons (IFNs), that drive tumor clearance. However, evidence suggests that tumor cells can also utilize IFNs to enhance growth and survival in certain cases. We demo... | Interferon Gamma-Inducible NAMPT in Melanoma Cells Serves as a Mechanism of Resistance to Enhance Tumor Growth
The tumor microenvironment is complex, with interacting immune and tumor cells. Immune cells release inflammatory cytokines, including interferons (IFNs), that drive tumor clearance. However, evidence suggest... | |
PMC10000698 | Hongxuan Li,Shiqian Fu,Danliangmin Song,Xue Qin,Wei Zhang,Chaoxin Man,Xinyan Yang,Yujun Jiang | Identification, Typing and Drug Resistance of Cronobacter spp. in Powdered Infant Formula and Processing Environment | 03-03-2023 | powdered infant formula,Cronobacter spp.,antibiotic resistance,multilocus sequence typing,transcriptomics | Cronobacter spp. is a food-borne pathogenic microorganism that can cause serious diseases such as meningitis, sepsis, and necrotizing colitis in infants and young children. Powdered infant formula (PIF) is one of the main contamination routes, in which the processing environment is an important source of pollution. In ... | Identification, Typing and Drug Resistance of Cronobacter spp. in Powdered Infant Formula and Processing Environment
Cronobacter spp. is a food-borne pathogenic microorganism that can cause serious diseases such as meningitis, sepsis, and necrotizing colitis in infants and young children. Powdered infant formula (PIF)... | |
PMC10000706 | Marcel Kemper,Carolin Krekeler,Kerstin Menck,Georg Lenz,Georg Evers,Arik Bernard Schulze,Annalen Bleckmann | Liquid Biopsies in Lung Cancer | 23-02-2023 | liquid biopsy,lung cancer,ctDNA,CTC,miRNA,EV | Simple Summary Liquid biopsy has recently been introduced as a novel method in cancer diagnostics. It is less invasive for patients than conventional tissue biopsies, as the assay material is drawn from peripheral blood. The detected DNA fragments, as well as the cells and extracellular vesicles, can be used as biomark... | Liquid Biopsies in Lung Cancer
Liquid biopsy has recently been introduced as a novel method in cancer diagnostics. It is less invasive for patients than conventional tissue biopsies, as the assay material is drawn from peripheral blood. The detected DNA fragments, as well as the cells and extracellular vesicles, can b... | |
PMC10000708 | Jiabin Yang,Liangtang Zeng,Ruiwan Chen,Leyi Huang,Zhuo Wu,Min Yu,Yu Zhou,Rufu Chen | Leveraging Tumor Microenvironment Infiltration in Pancreatic Cancer to Identify Gene Signatures Related to Prognosis and Immunotherapy Response | 24-02-2023 | pancreatic cancer,immune microenvironment,prognosis,immunotherapy,molecular subtype,F2RL1,therapeutic target | Simple Summary Pancreatic ductal adenocarcinoma (PDAC) has an insidious onset and rapid progression, and its morbidity and mortality are increasing year by year. Currently, there are limited therapeutic methods and no effective therapeutic guidance. Tumor microenvironments (TME) of PDAC are highly specific and associat... | Leveraging Tumor Microenvironment Infiltration in Pancreatic Cancer to Identify Gene Signatures Related to Prognosis and Immunotherapy Response
Pancreatic ductal adenocarcinoma (PDAC) has an insidious onset and rapid progression, and its morbidity and mortality are increasing year by year. Currently, there are limited... | |
PMC10000713 | Rosa Calvello,Chiara Porro,Dario Domenico Lofrumento,Melania Ruggiero,Maria Antonietta Panaro,Antonia Cianciulli | Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia | 21-02-2023 | microglia,resveratrol,decoy receptors,lipopolysaccharide,cytokines | Resveratrol is a polyphenol that acts as antioxidants do, protecting the body against diseases, such as diabetes, cancer, heart disease, and neurodegenerative disorders, such as Alzheimer’s (AD) and Parkinson’s diseases (PD). In the present study, we report that the treatment of activated microglia with resveratrol aft... | Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia
Resveratrol is a polyphenol that acts as antioxidants do, protecting the body against diseases, such as diabetes, cancer, heart disease, and neurodegenerative disorders, such as Alzheimer’s (AD) and Parkinson’s diseases (PD). In the pr... | |
PMC10000725 | Kristin E. Cox,Shanglei Liu,Thinzar M. Lwin,Robert M. Hoffman,Surinder K. Batra,Michael Bouvet | The Mucin Family of Proteins: Candidates as Potential Biomarkers for Colon Cancer | 27-02-2023 | mucins,colorectal cancer,adenocarcinoma,mucinous carcinoma,hyperplastic polyps,adenomatous polyps,adenoma,serrated polyps,prognostics | Simple Summary Colorectal cancer is the second leading cause of cancer-related deaths in the United States with an overall 5-year survival of 65%. While there have been many advances in the treatment of this disease over the past few decades, there has been minimal change in the overall five-year survival in the past t... | The Mucin Family of Proteins: Candidates as Potential Biomarkers for Colon Cancer
Colorectal cancer is the second leading cause of cancer-related deaths in the United States with an overall 5-year survival of 65%. While there have been many advances in the treatment of this disease over the past few decades, there has... | |
PMC10000735 | Iñigo Les,Mireia Martínez,Inés Pérez-Francisco,María Cabero,Lucía Teijeira,Virginia Arrazubi,Nuria Torrego,Ana Campillo-Calatayud,Iñaki Elejalde,Grazyna Kochan,David Escors | Predictive Biomarkers for Checkpoint Inhibitor Immune-Related Adverse Events | 06-03-2023 | immune-related adverse events,immune-checkpoint inhibitors,biomarkers,prediction,diagnosis | Simple Summary Immune-checkpoint inhibitors (ICIs) are increasingly used in the treatment of cancer, but they cause immune-related adverse events (irAEs) in around 40% of patients treated. Identifying biomarkers predictive of irAEs has become a priority for the optimal management of patients on ICIs. Herein, we review ... | Predictive Biomarkers for Checkpoint Inhibitor Immune-Related Adverse Events
Immune-checkpoint inhibitors (ICIs) are increasingly used in the treatment of cancer, but they cause immune-related adverse events (irAEs) in around 40% of patients treated. Identifying biomarkers predictive of irAEs has become a priority for... | |
PMC10000737 | Zeltzin Alejandra Ceja-Galicia,Ana Karina Aranda-Rivera,Isabel Amador-Martínez,Omar Emiliano Aparicio-Trejo,Edilia Tapia,Joyce Trujillo,Victoria Ramírez,José Pedraza-Chaverri | The Development of Dyslipidemia in Chronic Kidney Disease and Associated Cardiovascular Damage, and the Protective Effects of Curcuminoids | 22-02-2023 | curcumin,curcuminoids,chronic renal disease,cardiovascular disease (CVD),dyslipidemia,CKD | Chronic kidney disease (CKD) is a health problem that is constantly growing. This disease presents a diverse symptomatology that implies complex therapeutic management. One of its characteristic symptoms is dyslipidemia, which becomes a risk factor for developing cardiovascular diseases and increases the mortality of C... | The Development of Dyslipidemia in Chronic Kidney Disease and Associated Cardiovascular Damage, and the Protective Effects of Curcuminoids
Chronic kidney disease (CKD) is a health problem that is constantly growing. This disease presents a diverse symptomatology that implies complex therapeutic management. One of its ... | |
PMC10000741 | Elodie Villalonga,Christine Mosrin,Thierry Normand,Caroline Girardin,Amandine Serrano,Bojan Žunar,Michel Doudeau,Fabienne Godin,Hélène Bénédetti,Béatrice Vallée | LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features | 04-03-2023 | LIMK,actin dynamics,cytoskeleton remodelling,signalling pathways | LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases and the only two members of the LIM kinase family. They play a crucial role in the regulation of cytoskeleton dynamics by controlling actin filaments and microtubule turnover, especially through the phosphorylation of cofilin, an ac... | LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features
LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases and the only two members of the LIM kinase family. They play a crucial role in the regulation of cytoskeleton dynamics by co... | |
PMC10000745 | Dino Bekric,Daniel Neureiter,Celina Ablinger,Heidemarie Dobias,Marlena Beyreis,Markus Ritter,Martin Jakab,Johannes Bischof,Ulrich Koller,Tobias Kiesslich,Christian Mayr | Evaluation of Tazemetostat as a Therapeutically Relevant Substance in Biliary Tract Cancer | 02-03-2023 | biliary tract cancer,cholangiocarcinoma,EZH2 inhibitor,epigenetics,tazemetostat | Simple Summary Treating biliary tract cancer (BTC) successfully remains to be a difficult task. Standard therapeutic options encompass surgery, radiation and chemotherapy, but the median survival has not improved beyond one year. The reasons for this might be diagnosis at an already late stage and resistance towards cu... | Evaluation of Tazemetostat as a Therapeutically Relevant Substance in Biliary Tract Cancer
Treating biliary tract cancer (BTC) successfully remains to be a difficult task. Standard therapeutic options encompass surgery, radiation and chemotherapy, but the median survival has not improved beyond one year. The reasons f... | |
PMC10000746 | Ryan C. Hall,Amita M. Vaidya,William P. Schiemann,Quintin Pan,Zheng-Rong Lu | RNA-Seq Analysis of Extradomain A and Extradomain B Fibronectin as Extracellular Matrix Markers for Cancer | 21-02-2023 | extracellular matrix,tumor microenvironment,fibronectin,extradomain A fibronectin,extradomain B fibronectin | Alternatively spliced forms of fibronectin, called oncofetal fibronectin, are aberrantly expressed in cancer, with little to no expression in normal tissue, making them attractive biomarkers to exploit for tumor-targeted therapeutics and diagnostics. While prior studies have explored oncofetal fibronectin expression in... | RNA-Seq Analysis of Extradomain A and Extradomain B Fibronectin as Extracellular Matrix Markers for Cancer
Alternatively spliced forms of fibronectin, called oncofetal fibronectin, are aberrantly expressed in cancer, with little to no expression in normal tissue, making them attractive biomarkers to exploit for tumor-... | |
PMC10000752 | Ruth Aquino,Vidian de Concini,Marc Dhenain,Suzanne Lam,David Gosset,Laura Baquedano,Manuel G. Forero,Arnaud Menuet,Patrick Baril,Chantal Pichon | Intrahippocampal Inoculation of Aβ1–42 Peptide in Rat as a Model of Alzheimer’s Disease Identified MicroRNA-146a-5p as Blood Marker with Anti-Inflammatory Function in Astrocyte Cells | 22-02-2023 | microRNAs,miRNA-146a-5p,Alzheimer’s disease,Aβ1–42 peptide,biomarkers,diagnosis | Circulating microRNAs (miRNAs) have aroused a lot of interest as reliable blood diagnostic biomarkers of Alzheimer’s disease (AD). Here, we investigated the panel of expressed blood miRNAs in response to aggregated Aβ1–42 peptides infused in the hippocampus of adult rats to mimic events of the early onset of non-famili... | Intrahippocampal Inoculation of Aβ1–42 Peptide in Rat as a Model of Alzheimer’s Disease Identified MicroRNA-146a-5p as Blood Marker with Anti-Inflammatory Function in Astrocyte Cells
Circulating microRNAs (miRNAs) have aroused a lot of interest as reliable blood diagnostic biomarkers of Alzheimer’s disease (AD). Here,... | |
PMC10000757 | Maximilian Vidovic,Lars Hendrik Müschen,Svenja Brakemeier,Gerrit Machetanz,Marcel Naumann,Sergio Castro-Gomez | Current State and Future Directions in the Diagnosis of Amyotrophic Lateral Sclerosis | 24-02-2023 | amyotrophic lateral sclerosis,ALS,motor neuron disease,MND,diagnosis,diagnostics | Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary muscles and eventual respiratory failure. Non-motor symptoms, such as cognitive and behavioral changes, frequently occur over the course of ... | Current State and Future Directions in the Diagnosis of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary muscles and eventual respiratory failure. Non-motor s... | |
PMC10000760 | Mihaela Roșca,Gabriela Mihalache,Vasile Stoleru | Tomato responses to salinity stress: From morphological traits to genetic changes | 10-02-2023 | abiotic stress,PRISMA,salt stress,screening of salinity effects,tomato,alleviation of salinity effects | Tomato is an essential annual crop providing human food worldwide. It is estimated that by the year 2050 more than 50% of the arable land will become saline and, in this respect, in recent years, researchers have focused their attention on studying how tomato plants behave under various saline conditions. Plenty of res... | Tomato responses to salinity stress: From morphological traits to genetic changes
Tomato is an essential annual crop providing human food worldwide. It is estimated that by the year 2050 more than 50% of the arable land will become saline and, in this respect, in recent years, researchers have focused their attention ... | |
PMC10000761 | Johnny Atallah,Musie Ghebremichael,Kyle D. Timmer,Hailey M. Warren,Ella Mallinger,Ellen Wallace,Fiona R. Strouts,David H. Persing,Michael K. Mansour | Novel Host Response-Based Diagnostics to Differentiate the Etiology of Fever in Patients Presenting to the Emergency Department † | 02-03-2023 | host-response,diagnostics,gene signatures,fever,febrile syndromes | Fever is a common presentation to urgent-care services and is linked to multiple disease processes. To rapidly determine the etiology of fever, improved diagnostic modalities are necessary. This prospective study of 100 hospitalized febrile patients included both positive (FP) and negative (FN) subjects in terms of inf... | Novel Host Response-Based Diagnostics to Differentiate the Etiology of Fever in Patients Presenting to the Emergency Department †
Fever is a common presentation to urgent-care services and is linked to multiple disease processes. To rapidly determine the etiology of fever, improved diagnostic modalities are necessary.... | |
PMC10000766 | Mona A. Amin,Halla M. Ragab,Nabila Abd El Maksoud,Wafaa Abd Elaziz | CD24 Gene Expression as a Risk Factor for Non-Alcoholic Fatty Liver Disease | 04-03-2023 | NAFLD,gene expression,CD24 | In light of increasing NAFLD prevalence, early detection and diagnosis are needed for decision-making in clinical practice and could be helpful in the management of patients with NAFLD. The goal of this study was to evaluate the diagnostic accuracy of CD24 gene expression as a non-invasive tool to detect hepatic steato... | CD24 Gene Expression as a Risk Factor for Non-Alcoholic Fatty Liver Disease
In light of increasing NAFLD prevalence, early detection and diagnosis are needed for decision-making in clinical practice and could be helpful in the management of patients with NAFLD. The goal of this study was to evaluate the diagnostic acc... | |
PMC10000776 | Hitha Gopalan Nair,Aneta Jurkiewicz,Damian Graczyk | Inhibition of RNA Polymerase III Augments the Anti-Cancer Properties of TNFα | 27-02-2023 | RNA polymerase III,cancer,TNFα,NF-κB | Simple Summary Tumour necrosis factor alpha (TNFα) is a cytokine that plays an important role in apoptosis, cell survival, as well as in inflammation and immunity. Although named for its antitumor properties, TNFα has tumour-promoting properties. TNFα is often present in large quantities in tumours, and cancer cells fr... | Inhibition of RNA Polymerase III Augments the Anti-Cancer Properties of TNFα
Tumour necrosis factor alpha (TNFα) is a cytokine that plays an important role in apoptosis, cell survival, as well as in inflammation and immunity. Although named for its antitumor properties, TNFα has tumour-promoting properties. TNFα is of... | |
PMC10000778 | Pusheng Yang,Jiawei Lu,Panpan Zhang,Shu Zhang | Comprehensive Analysis of Prognosis and Immune Landscapes Based on Lipid-Metabolism- and Ferroptosis-Associated Signature in Uterine Corpus Endometrial Carcinoma | 24-02-2023 | lipid metabolism,ferroptosis,immunotherapy,prognostic marker,uterine corpus endometrial carcinoma | (1) Background: The effect of tumor immunotherapy is influenced by the immune microenvironment, and it is unclear how lipid metabolism and ferroptosis regulate the immune microenvironment of uterine corpus endometrial carcinoma (UCEC). (2) Methods: Genes associated with lipid metabolism and ferroptosis (LMRGs-FARs) wer... | Comprehensive Analysis of Prognosis and Immune Landscapes Based on Lipid-Metabolism- and Ferroptosis-Associated Signature in Uterine Corpus Endometrial Carcinoma
(1) Background: The effect of tumor immunotherapy is influenced by the immune microenvironment, and it is unclear how lipid metabolism and ferroptosis regula... | |
PMC10000782 | Anna Citarella,Giuseppina Catanzaro,Zein Mersini Besharat,Sofia Trocchianesi,Federica Barbagallo,Giorgio Gosti,Marco Leonetti,Annamaria Di Fiore,Lucia Coppola,Tanja Milena Autilio,Zaira Spinello,Alessandra Vacca,Enrico De Smaele,Mary Anna Venneri,Elisabetta Ferretti,Laura Masuelli,Agnese Po | Hedgehog-GLI and Notch Pathways Sustain Chemoresistance and Invasiveness in Colorectal Cancer and Their Inhibition Restores Chemotherapy Efficacy | 25-02-2023 | colorectal cancer,signaling pathways,chemoresistance,epithelial-to-mesenchymal transition,organoids | Simple Summary Colorectal cancer is a leading cause of cancer-related deaths, mainly caused by resistance to therapy and metastatic spread, in turn sustained by the activation of mechanisms such as the epithelial-to-mesenchymal transition (EMT). We investigate here the role of the Hedgehog-GLI and NOTCH signaling pathw... | Hedgehog-GLI and Notch Pathways Sustain Chemoresistance and Invasiveness in Colorectal Cancer and Their Inhibition Restores Chemotherapy Efficacy
Colorectal cancer is a leading cause of cancer-related deaths, mainly caused by resistance to therapy and metastatic spread, in turn sustained by the activation of mechanism... | |
PMC10000786 | Shayan Shafiee,Jaidip Jagtap,Mykhaylo Zayats,Jonathan Epperlein,Anjishnu Banerjee,Aron Geurts,Michael Flister,Sergiy Zhuk,Amit Joshi | Dynamic NIR Fluorescence Imaging and Machine Learning Framework for Stratifying High vs. Low Notch-Dll4 Expressing Host Microenvironment in Triple-Negative Breast Cancer | 25-02-2023 | cancer,tumor microenvironment modifier,notch-DLL4,consomic xenograft model,machine learning,binary classification,dynamic enhanced NIR imaging,indocyanine green,time series,tumor detection | Simple Summary Breast cancer is a disease that is affected by both the tumor cells and the host environment. It is well known that the tumor blood vessels are aberrant in structure and function due to rapid angiogenesis, and this aberrant vasculature plays a major role in drug delivery and therapy response of breast ca... | Dynamic NIR Fluorescence Imaging and Machine Learning Framework for Stratifying High vs. Low Notch-Dll4 Expressing Host Microenvironment in Triple-Negative Breast Cancer
Breast cancer is a disease that is affected by both the tumor cells and the host environment. It is well known that the tumor blood vessels are aberr... | |
PMC10000814 | Hussein Awada,Valeria Visconte | The Heterogeneous Complexity of Myeloid Neoplasm: Multi-Level Approaches to Study the Disease | 24-02-2023 | The Heterogeneous Complexity of Myeloid Neoplasm: Multi-Level Approaches to Study the Disease
Myeloid neoplasms (MNs) include a spectrum of bone marrow malignancies that result from the clonal expansion and arrest of differentiation of myeloid progenitor cells [1]. MNs account for around 25% of all hematological malig... | |||
PMC10000817 | David Dubayle,Arnaud Vanden-Bossche,Tom Peixoto,Jean-Luc Morel | Hypergravity Increases Blood–Brain Barrier Permeability to Fluorescent Dextran and Antisense Oligonucleotide in Mice | 24-02-2023 | blood–brain barrier,permeability,centrifugation,hypergravity,dextran,antisense oligonucleotide | The earliest effect of spaceflight is an alteration in vestibular function due to microgravity. Hypergravity exposure induced by centrifugation is also able to provoke motion sickness. The blood–brain barrier (BBB) is the crucial interface between the vascular system and the brain to ensure efficient neuronal activity.... | Hypergravity Increases Blood–Brain Barrier Permeability to Fluorescent Dextran and Antisense Oligonucleotide in Mice
The earliest effect of spaceflight is an alteration in vestibular function due to microgravity. Hypergravity exposure induced by centrifugation is also able to provoke motion sickness. The blood–brain b... | |
PMC10000819 | Walter Mancino,Paola Carnevali,Valeria Terzi,Pascual García Pérez,Leilei Zhang,Gianluca Giuberti,Lorenzo Morelli,Vania Patrone,Luigi Lucini | Hierarchical Effects of Lactic Fermentation and Grain Germination on the Microbial and Metabolomic Profile of Rye Doughs | 27-02-2023 | LAB,yeast,fermentation,rye,metagenomics,dough,metabolomics,germination | A multi-omics approach was adopted to investigate the impact of lactic acid fermentation and seed germination on the composition and physicochemical properties of rye doughs. Doughs were prepared with either native or germinated rye flour and fermented with Saccharomyces cerevisiae, combined or not with a sourdough sta... | Hierarchical Effects of Lactic Fermentation and Grain Germination on the Microbial and Metabolomic Profile of Rye Doughs
A multi-omics approach was adopted to investigate the impact of lactic acid fermentation and seed germination on the composition and physicochemical properties of rye doughs. Doughs were prepared wi... | |
PMC10000829 | Giuseppe Schepisi,Caterina Gianni,Michela Palleschi,Sara Bleve,Chiara Casadei,Cristian Lolli,Laura Ridolfi,Giovanni Martinelli,Ugo De Giorgi | The New Frontier of Immunotherapy: Chimeric Antigen Receptor T (CAR-T) Cell and Macrophage (CAR-M) Therapy against Breast Cancer | 04-03-2023 | chimeric antigen receptor (CAR),macrophages,T cells,immunotherapy,breast cancer | Simple Summary To date, different therapeutic strategies, including immunotherapies, have been shown to prolong survival in breast cancer patients, representing one of the most common malignancies. Our article deals with chimeric antigen receptor-based immunotherapy in breast cancer. Abstract Breast cancer represents o... | The New Frontier of Immunotherapy: Chimeric Antigen Receptor T (CAR-T) Cell and Macrophage (CAR-M) Therapy against Breast Cancer
To date, different therapeutic strategies, including immunotherapies, have been shown to prolong survival in breast cancer patients, representing one of the most common malignancies. Our art... | |
PMC10000854 | Yi Xu,Somaira Nowsheen,Min Deng | DNA Repair Deficiency Regulates Immunity Response in Cancers: Molecular Mechanism and Approaches for Combining Immunotherapy | 06-03-2023 | DNA damage response,cancer therapy,immunotherapy,cell death,biomarker,tumor microenvironment,DNA repair,cell death | Simple Summary DNA repair pathways play a crucial role in maintaining the stability of a cell’s genetic material. When these pathways are defective, it can lead to genomic instability in cancer cells, which can increase their ability to stimulate an immune response. Inhibiting DNA damage response, the process that help... | DNA Repair Deficiency Regulates Immunity Response in Cancers: Molecular Mechanism and Approaches for Combining Immunotherapy
DNA repair pathways play a crucial role in maintaining the stability of a cell’s genetic material. When these pathways are defective, it can lead to genomic instability in cancer cells, which ca... | |
PMC10000856 | Zheyuan Hu,Penghui Zhao,Aimei Liao,Long Pan,Jie Zhang,Yuqi Dong,Jihong Huang,Weiwei He,Xingqi Ou | Fermented Wheat Germ Alleviates Depression-like Behavior in Rats with Chronic and Unpredictable Mild Stress | 22-02-2023 | FWG,depression,behavior,neurotransmitters,intestinal microbes | Depression is a chronic mental illness with devastating effects on a person’s physical and mental health. Studies have reported that food fermentation with probiotics can enrich the nutritional values of food and produce functional microorganisms that can alleviate depression and anxiety. Wheat germ is an inexpensive r... | Fermented Wheat Germ Alleviates Depression-like Behavior in Rats with Chronic and Unpredictable Mild Stress
Depression is a chronic mental illness with devastating effects on a person’s physical and mental health. Studies have reported that food fermentation with probiotics can enrich the nutritional values of food an... | |
PMC10000868 | Jurate Valciukiene,Kestutis Strupas,Tomas Poskus | Tissue vs. Fecal-Derived Bacterial Dysbiosis in Precancerous Colorectal Lesions: A Systematic Review | 04-03-2023 | intestinal microbiota,colorectal adenoma,colorectal neoplasm,polyp,gut,carcinoma in situ,tissue-derived,fecal-derived dysbiosis,mucosa samples,stool,bacteria | Simple Summary Although alterations of intestinal bacterial microbiota have been admitted as playing one of the most important roles in colorectal carcinogenesis, the links between microbiota compositional changes and premalignant colorectal polyps have still not been fully examined. Furthermore, there is a lack of kno... | Tissue vs. Fecal-Derived Bacterial Dysbiosis in Precancerous Colorectal Lesions: A Systematic Review
Although alterations of intestinal bacterial microbiota have been admitted as playing one of the most important roles in colorectal carcinogenesis, the links between microbiota compositional changes and premalignant co... | |
PMC10000871 | Phuong-Thu Mai,Daejin Lim,EunA So,Ha Young Kim,Taner Duysak,Thanh-Quang Tran,Miryoung Song,Jae-Ho Jeong,Hyon E. Choy | Constitutive Expression of a Cytotoxic Anticancer Protein in Tumor-Colonizing Bacteria | 27-02-2023 | Escherichia coli,Salmonella enterica serovar Gallinarum,anticancer protein expression,host response,bacterial cancer therapy | Simple Summary This study examined the biodistribution of Escherichia coli and an attenuated strain of Salmonella enterica serovar Gallinarum with defective ppGpp synthesis after injection into tumor-bearing mice through the tail vein. Bacteria targeting tumor tissues, but not those in the liver and spleen, were metabo... | Constitutive Expression of a Cytotoxic Anticancer Protein in Tumor-Colonizing Bacteria
This study examined the biodistribution of Escherichia coli and an attenuated strain of Salmonella enterica serovar Gallinarum with defective ppGpp synthesis after injection into tumor-bearing mice through the tail vein. Bacteria ta... | |
PMC10000876 | Thimios A. Mitsiadis,Pierfrancesco Pagella,Helder Gomes Rodrigues,Alexander Tsouknidas,Liza L. Ramenzoni,Freddy Radtke,Albert Mehl,Laurent Viriot | Notch Signaling Pathway in Tooth Shape Variations throughout Evolution | 27-02-2023 | notch signaling,Jagged1,RNA analysis,mouse,human,tooth,dental morphology,evolution,differentiation | Evolutionary changes in vertebrates are linked to genetic alterations that often affect tooth crown shape, which is a criterion of speciation events. The Notch pathway is highly conserved between species and controls morphogenetic processes in most developing organs, including teeth. Epithelial loss of the Notch-ligand... | Notch Signaling Pathway in Tooth Shape Variations throughout Evolution
Evolutionary changes in vertebrates are linked to genetic alterations that often affect tooth crown shape, which is a criterion of speciation events. The Notch pathway is highly conserved between species and controls morphogenetic processes in most... | |
PMC10000881 | Olivia G. Huffman,Danielle B. Chau,Andreea I. Dinicu,Robert DeBernardo,Ofer Reizes | Mechanistic Insights on Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer | 22-02-2023 | hyperthermia,ovarian cancer,immunity,chemotherapy,HIPEC | Simple Summary Advanced ovarian cancer is the leading cause of gynecological death with a high rate of reoccurrence indicating the critical need for improved therapeutics. Hyperthermic intraperitoneal chemotherapy (HIPEC) treatment for ovarian cancer has shown efficacy in extending patient overall survival yet the mech... | Mechanistic Insights on Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer
Advanced ovarian cancer is the leading cause of gynecological death with a high rate of reoccurrence indicating the critical need for improved therapeutics. Hyperthermic intraperitoneal chemotherapy (HIPEC) treatment for ovarian cancer... | |
PMC10000883 | Iwona A. Ciechomska,Kamil Wojnicki,Bartosz Wojtas,Paulina Szadkowska,Katarzyna Poleszak,Beata Kaza,Kinga Jaskula,Wiktoria Dawidczyk,Ryszard Czepko,Mariusz Banach,Bartosz Czapski,Pawel Nauman,Katarzyna Kotulska,Wieslawa Grajkowska,Marcin Roszkowski,Tomasz Czernicki,Andrzej Marchel,Bozena Kaminska | Exploring Novel Therapeutic Opportunities for Glioblastoma Using Patient-Derived Cell Cultures | 02-03-2023 | glioblastoma,cancer stem cells,EMT,MGMT,temozolomide,doxorubicin,STAT3,EGFR inhibitor (AG1478) | Simple Summary Glioblastomas (GBM) are aggressive brain tumors with poor prognosis that need effective treatment. GBMs are characterized by extensive cellular and molecular heterogeneity which are reflected in patient-derived cell cultures, frequently used in testing potential therapeutics. Here, we established GBM-der... | Exploring Novel Therapeutic Opportunities for Glioblastoma Using Patient-Derived Cell Cultures
Glioblastomas (GBM) are aggressive brain tumors with poor prognosis that need effective treatment. GBMs are characterized by extensive cellular and molecular heterogeneity which are reflected in patient-derived cell cultures... | |
PMC10000888 | Leonie T. D. Wuerger,Felicia Kudiabor,Jimmy Alarcan,Markus Templin,Oliver Poetz,Holger Sieg,Albert Braeuning | Okadaic Acid Activates JAK/STAT Signaling to Affect Xenobiotic Metabolism in HepaRG Cells | 28-02-2023 | okadaic acid,HepaRG cells,CYP enzymes,NF-κB,JAK/STAT,inflammation | Okadaic acid (OA) is a marine biotoxin that is produced by algae and accumulates in filter-feeding shellfish, through which it enters the human food chain, leading to diarrheic shellfish poisoning (DSP) after ingestion. Furthermore, additional effects of OA have been observed, such as cytotoxicity. Additionally, a stro... | Okadaic Acid Activates JAK/STAT Signaling to Affect Xenobiotic Metabolism in HepaRG Cells
Okadaic acid (OA) is a marine biotoxin that is produced by algae and accumulates in filter-feeding shellfish, through which it enters the human food chain, leading to diarrheic shellfish poisoning (DSP) after ingestion. Furthermo... | |
PMC10000895 | Sabine Weiskirchen,Sarah K. Schröder,Eva Miriam Buhl,Ralf Weiskirchen | A Beginner’s Guide to Cell Culture: Practical Advice for Preventing Needless Problems | 21-02-2023 | contamination,mycoplasma,retrovirus,STR profiling,misidentification,cell authentication,conditional reprogramming | The cultivation of cells in a favorable artificial environment has become a versatile tool in cellular and molecular biology. Cultured primary cells and continuous cell lines are indispensable in investigations of basic, biomedical, and translation research. However, despite their important role, cell lines are frequen... | A Beginner’s Guide to Cell Culture: Practical Advice for Preventing Needless Problems
The cultivation of cells in a favorable artificial environment has become a versatile tool in cellular and molecular biology. Cultured primary cells and continuous cell lines are indispensable in investigations of basic, biomedical, ... | |
PMC10000902 | Huriye Ercan,Ulrike Resch,Felicia Hsu,Goran Mitulovic,Andrea Bileck,Christopher Gerner,Jae-Won Yang,Margarethe Geiger,Ingrid Miller,Maria Zellner | A Practical and Analytical Comparative Study of Gel-Based Top-Down and Gel-Free Bottom-Up Proteomics Including Unbiased Proteoform Detection | 26-02-2023 | top-down proteomics,2D-DIGE,bottom-up proteomics,shotgun proteomics,proteoforms,post-translational modification (PTM) | Proteomics is an indispensable analytical technique to study the dynamic functioning of biological systems via different proteins and their proteoforms. In recent years, bottom-up shotgun has become more popular than gel-based top-down proteomics. The current study examined the qualitative and quantitative performance ... | A Practical and Analytical Comparative Study of Gel-Based Top-Down and Gel-Free Bottom-Up Proteomics Including Unbiased Proteoform Detection
Proteomics is an indispensable analytical technique to study the dynamic functioning of biological systems via different proteins and their proteoforms. In recent years, bottom-u... | |
PMC10000907 | Yang Wang,Muhammad Ali,Qi Zhang,Qiannan Sun,Jun Ren,Wei Wang,Dong Tang,Daorong Wang | ATF4 Transcriptionally Activates SHH to Promote Proliferation, Invasion, and Migration of Gastric Cancer Cells | 23-02-2023 | transcriptional factor,ATF4,SHH,gastric cancer | Simple Summary Gastric cancer (GC) is the world’s third greatest cause of cancer-related death. Since the underlying pathogenic mechanisms are still unclear and only a limited number of specialized drugs have been developed, treating GC patients in clinical practice remains challenging. We observed that ATF4 was marked... | ATF4 Transcriptionally Activates SHH to Promote Proliferation, Invasion, and Migration of Gastric Cancer Cells
Gastric cancer (GC) is the world’s third greatest cause of cancer-related death. Since the underlying pathogenic mechanisms are still unclear and only a limited number of specialized drugs have been developed... | |
PMC10000908 | Nesrine Ben Mhenni,Giulia Alberghini,Valerio Giaccone,Alessandro Truant,Paolo Catellani | Prevalence and Antibiotic Resistance Phenotypes of Pseudomonas spp. in Fresh Fish Fillets | 23-02-2023 | Pseudomonas spp.,fish fillets,food microbiology,antimicrobial resistance,multi-drug resistance | In fresh fish products, excessive loads of Pseudomonas can lead to their rapid spoilage. It is wise for Food Business Operators (FBOs) to consider its presence both in whole and prepared fish products. With the current study, we aimed to quantify Pseudomonas spp. in fresh fillets of Salmo salar, Gadus morhua and Pleuro... | Prevalence and Antibiotic Resistance Phenotypes of Pseudomonas spp. in Fresh Fish Fillets
In fresh fish products, excessive loads of Pseudomonas can lead to their rapid spoilage. It is wise for Food Business Operators (FBOs) to consider its presence both in whole and prepared fish products. With the current study, we ... | |
PMC10000909 | Ehsan Gharib,Parinaz Nasri Nasrabadi,Gilles A. Robichaud | Circular RNA Expression Signatures Provide Promising Diagnostic and Therapeutic Biomarkers for Chronic Lymphocytic Leukemia | 01-03-2023 | cancer,chronic lymphocytic leukemia,circular RNA,diagnosis,prognosis,drug sensitivity prediction | Simple Summary This study aimed to evaluate the potential of circular RNA (circRNA) expression profiles for the early detection of chronic lymphocytic leukemia (CLL) using bioinformatic algorithms on verified CLL patient datasets. We analyzed and validated the diagnostic performance of circRNAs as potential biomarkers ... | Circular RNA Expression Signatures Provide Promising Diagnostic and Therapeutic Biomarkers for Chronic Lymphocytic Leukemia
This study aimed to evaluate the potential of circular RNA (circRNA) expression profiles for the early detection of chronic lymphocytic leukemia (CLL) using bioinformatic algorithms on verified C... | |
PMC10000922 | Eishin Morita,Hiroaki Matsuo,Kunie Kohno,Tomoharu Yokooji,Hiroyuki Yano,Takashi Endo | A Narrative Mini Review on Current Status of Hypoallergenic Wheat Development for IgE-Mediated Wheat Allergy, Wheat-Dependent Exercise-Induced Anaphylaxis | 23-02-2023 | deamidation,enzymic degradation,hypoallergenic wheat,ω5-gliadin,thioredoxin,wheat-dependent exercise-induced anaphylaxis | Immunoglobulin E (IgE)-mediated food allergies to wheat that develop after school age typically shows a type of wheat-dependent exercise-induced anaphylaxis (WDEIA). At present, avoidance of wheat products or postprandial rest after ingesting wheat is recommended for patients with WDEIA, depending on the severity of th... | A Narrative Mini Review on Current Status of Hypoallergenic Wheat Development for IgE-Mediated Wheat Allergy, Wheat-Dependent Exercise-Induced Anaphylaxis
Immunoglobulin E (IgE)-mediated food allergies to wheat that develop after school age typically shows a type of wheat-dependent exercise-induced anaphylaxis (WDEIA)... | |
PMC10000926 | Mengyuan Li,Angela Quintana,Elena Alberts,Miu Shing Hung,Victoire Boulat,Mercè Martí Ripoll,Anita Grigoriadis | B Cells in Breast Cancer Pathology | 28-02-2023 | B cells,tumour-infiltrating lymphocytes,breast cancer,tertiary lymphoid structures,lymph nodes,germinal centres | Simple Summary B cells in the tumour microenvironment and lymph nodes have affirmed their role in breast cancer pathology. Multiplex imaging, single cell, and spatial transcriptomics of cancer patients’ breast carcinomas and lymph nodes have illustrated the diversity and spatial context of B cells in this disease. Thei... | B Cells in Breast Cancer Pathology
B cells in the tumour microenvironment and lymph nodes have affirmed their role in breast cancer pathology. Multiplex imaging, single cell, and spatial transcriptomics of cancer patients’ breast carcinomas and lymph nodes have illustrated the diversity and spatial context of B cells ... | |
PMC10000927 | Benson Chellakkan Selvanesan,Alvaro de Mingo Pulido,Sheelu Varghese,Deepak Rohila,Daniel Hupalo,Yuriy Gusev,Sara Contente,Matthew D. Wilkerson,Clifton L. Dalgard,Geeta Upadhyay | NSC243928 Treatment Induces Anti-Tumor Immune Response in Mouse Mammary Tumor Models | 25-02-2023 | LY6K,mammary tumor model,NKT cells,B1 cells,myeloid derived suppressor cells,NSC243928,4T1,E0771 | Simple Summary This study used two different syngeneic mouse mammary tumor models to determine the effect of a small molecule NSC243928 on intra-tumoral immune cells. We observed that NSC243928 treatment reduced the tumor burden in vivo and altered the wide range of immune cell infiltration in both models. These result... | NSC243928 Treatment Induces Anti-Tumor Immune Response in Mouse Mammary Tumor Models
This study used two different syngeneic mouse mammary tumor models to determine the effect of a small molecule NSC243928 on intra-tumoral immune cells. We observed that NSC243928 treatment reduced the tumor burden in vivo and altered ... | |
PMC10000933 | Artem Pilunov,Dmitrii S. Romaniuk,Anton Shmelev,Savely Sheetikov,Anna N. Gabashvili,Alexandra Khmelevskaya,Dmitry Dianov,Ksenia Zornikova,Naina T. Shakirova,Murad Vagida,Apollinariya Bogolyubova,Grigory A. Efimov | Transgenic HA-1-Specific CD8+ T-Lymphocytes Selectively Target Leukemic Cells | 03-03-2023 | adoptive transfer,acute myeloid leukemia,transgenic TCR,allo-HSCT,minor histocompatibility antigens,HA-1 | Simple Summary A relapse of the malignant disease frequently occurs after allogeneic hematopoietic stem cell transplantation. Immune recognition of minor histocompatibility antigens, the polymorphic peptides that differ between donor and recipient, often triggers a beneficial graft-versus-leukemia response. The transge... | Transgenic HA-1-Specific CD8+ T-Lymphocytes Selectively Target Leukemic Cells
A relapse of the malignant disease frequently occurs after allogeneic hematopoietic stem cell transplantation. Immune recognition of minor histocompatibility antigens, the polymorphic peptides that differ between donor and recipient, often t... | |
PMC10000935 | Reza Zarinshenas,Arya Amini,Isa Mambetsariev,Tariq Abuali,Jeremy Fricke,Colton Ladbury,Ravi Salgia | Assessment of Barriers and Challenges to Screening, Diagnosis, and Biomarker Testing in Early-Stage Lung Cancer | 03-03-2023 | lung cancer,screening,biomarkers,LDCT,COVID-19 | Simple Summary Lung cancer management continues to evolve with improvements in survival across all stages. The review highlights the current data supporting screening and discusses barriers to screening and potential opportunities to improve screening access. Further, the review discusses the current challenges in diag... | Assessment of Barriers and Challenges to Screening, Diagnosis, and Biomarker Testing in Early-Stage Lung Cancer
Lung cancer management continues to evolve with improvements in survival across all stages. The review highlights the current data supporting screening and discusses barriers to screening and potential oppor... | |
PMC10000936 | Henriett Butz,Éva Saskői,Lilla Krokker,Viktória Vereczki,Alán Alpár,István Likó,Erika Tóth,Erika Szőcs,Mihály Cserepes,Katalin Nagy,Imre Kacskovics,Attila Patócs | Context-Dependent Role of Glucocorticoid Receptor Alpha and Beta in Breast Cancer Cell Behaviour | 01-03-2023 | glucocorticoid receptor,glucocorticoid receptor alpha,glucocorticoid receptor beta,breast cancer,proliferation,migration,breast cancer progression,metastasis | Background. The dual role of GCs has been observed in breast cancer; however, due to many concomitant factors, GR action in cancer biology is still ambiguous. In this study, we aimed to unravel the context-dependent action of GR in breast cancer. Methods. GR expression was characterized in multiple cohorts: (1) 24,256 ... | Context-Dependent Role of Glucocorticoid Receptor Alpha and Beta in Breast Cancer Cell Behaviour
Background. The dual role of GCs has been observed in breast cancer; however, due to many concomitant factors, GR action in cancer biology is still ambiguous. In this study, we aimed to unravel the context-dependent action... | |
PMC10000937 | Qiyu Gan,Luning Mao,Rui Shi,Linlin Chang,Guozeng Wang,Jingxin Cheng,Rui Chen | Prognostic Value and Immune Infiltration of HPV-Related Genes in the Immune Microenvironment of Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma | 23-02-2023 | cervical squamous cell carcinoma and endocervical adenocarcinoma,TCGA datasets,immune microenvironment,HPV | Simple Summary Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) generally presents with HPV infection and is the second most common gynecological malignancy. However, the effect of immune infiltrate and immune microenvironment on the tumorigenesis and development of CESC remains unclear. In this ... | Prognostic Value and Immune Infiltration of HPV-Related Genes in the Immune Microenvironment of Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma
Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) generally presents with HPV infection and is the second most common gynecological mali... | |
PMC10000941 | Alicja Rajtak,Arkadiusz Czerwonka,Michael Pitter,Jan Kotarski,Karolina Okła | Clinical Relevance of Mortalin in Ovarian Cancer Patients | 23-02-2023 | mortalin/mtHsp70/GRP75/PBP74/HSPA9/HSPA9B,ovarian cancer,biomarker,metastasis,recurrence,OXPHOS,EMT,stemness,RNAseq | Background: Ovarian cancer (OC) is the most lethal malignancy of the female reproductive tract. Consequently, a better understanding of the malignant features in OC is pertinent. Mortalin (mtHsp70/GRP75/PBP74/HSPA9/HSPA9B) promotes cancer development, progression, metastasis, and recurrence. Yet, there is no parallel e... | Clinical Relevance of Mortalin in Ovarian Cancer Patients
Background: Ovarian cancer (OC) is the most lethal malignancy of the female reproductive tract. Consequently, a better understanding of the malignant features in OC is pertinent. Mortalin (mtHsp70/GRP75/PBP74/HSPA9/HSPA9B) promotes cancer development, progressi... | |
PMC10000962 | Naresh Kumar Manda,Upendarrao Golla,Kishore Sesham,Parth Desai,Shrushti Joshi,Satyam Patel,Sharada Nalla,Susmitha Kondam,Lakhwinder Singh,Deepak Dewansh,Hemalatha Manda,Namita Rokana | Tuning between Nuclear Organization and Functionality in Health and Disease | 23-02-2023 | nuclear shape regulation,nuclear size regulation,nuclear envelope proteins,nucleophagy,nuclear lamins,nucleopathy,cancer,neurodegenerative disorders,signaling pathways,targeted therapy | The organization of eukaryotic genome in the nucleus, a double-membraned organelle separated from the cytoplasm, is highly complex and dynamic. The functional architecture of the nucleus is confined by the layers of internal and cytoplasmic elements, including chromatin organization, nuclear envelope associated proteom... | Tuning between Nuclear Organization and Functionality in Health and Disease
The organization of eukaryotic genome in the nucleus, a double-membraned organelle separated from the cytoplasm, is highly complex and dynamic. The functional architecture of the nucleus is confined by the layers of internal and cytoplasmic el... | |
PMC10000963 | Giulia Cencelli,Laura Pacini,Anastasia De Luca,Ilenia Messia,Antonietta Gentile,Yunhee Kang,Veronica Nobile,Elisabetta Tabolacci,Peng Jin,Maria Giulia Farace,Claudia Bagni | Age-Dependent Dysregulation of APP in Neuronal and Skin Cells from Fragile X Individuals | 27-02-2023 | Fragile X syndrome,APP processing,protein synthesis,peptide therapy,iPSCs,ADAM10,SAP97 | Fragile X syndrome (FXS) is the most common form of monogenic intellectual disability and autism, caused by the absence of the functional fragile X messenger ribonucleoprotein 1 (FMRP). FXS features include increased and dysregulated protein synthesis, observed in both murine and human cells. Altered processing of the ... | Age-Dependent Dysregulation of APP in Neuronal and Skin Cells from Fragile X Individuals
Fragile X syndrome (FXS) is the most common form of monogenic intellectual disability and autism, caused by the absence of the functional fragile X messenger ribonucleoprotein 1 (FMRP). FXS features include increased and dysregula... | |
PMC10000966 | Lina Che,Caixia Zhu,Lei Huang,Hui Xu,Xinmiao Ma,Xuegang Luo,Hongpeng He,Tongcun Zhang,Nan Wang | Ginsenoside Rg2 Promotes the Proliferation and Stemness Maintenance of Porcine Mesenchymal Stem Cells through Autophagy Induction | 02-03-2023 | mesenchymal stem cells,cultivated meat,ginsenoside Rg2,proliferation,replicative senescence,autophagy | Mesenchymal stem cells (MSCs) can be used as a cell source for cultivated meat production due to their adipose differentiation potential, but MSCs lose their stemness and undergo replicative senescence during expansion in vitro. Autophagy is an important mechanism for senescent cells to remove toxic substances. However... | Ginsenoside Rg2 Promotes the Proliferation and Stemness Maintenance of Porcine Mesenchymal Stem Cells through Autophagy Induction
Mesenchymal stem cells (MSCs) can be used as a cell source for cultivated meat production due to their adipose differentiation potential, but MSCs lose their stemness and undergo replicativ... | |
PMC10000969 | Jazmin Rivera,Laxman Gangwani,Subodh Kumar | Mitochondria Localized microRNAs: An Unexplored miRNA Niche in Alzheimer’s Disease and Aging | 25-02-2023 | mitochondrial miRNAs,Alzheimer’s disease,mitochondrial dysfunction,synaptic energy,aging | Mitochondria play several vital roles in the brain cells, especially in neurons to provide synaptic energy (ATP), Ca2+ homeostasis, Reactive Oxygen Species (ROS) production, apoptosis, mitophagy, axonal transport and neurotransmission. Mitochondrial dysfunction is a well-established phenomenon in the pathophysiology of... | Mitochondria Localized microRNAs: An Unexplored miRNA Niche in Alzheimer’s Disease and Aging
Mitochondria play several vital roles in the brain cells, especially in neurons to provide synaptic energy (ATP), Ca2+ homeostasis, Reactive Oxygen Species (ROS) production, apoptosis, mitophagy, axonal transport and neurotran... | |
PMC10000974 | Evan N. Cohen,Gitanjali Jayachandran,Hui Gao,Phillip Peabody,Heather B. McBride,Franklin D. Alvarez,Megumi Kai,Juhee Song,Yu Shen,Jie S. Willey,Bora Lim,Vicente Valero,Naoto T. Ueno,James M. Reuben | Phenotypic Plasticity in Circulating Tumor Cells Is Associated with Poor Response to Therapy in Metastatic Breast Cancer Patients | 06-03-2023 | circulating tumor cells (CTCs),neoplastic cells,circulating,neoplasms/diagnosis,circulating/pathology,biopsy,breast neoplasms/pathology,breast cancer,biomarkers,tumor,blood,liquid biopsy,metastatic process,EMT | Simple Summary Circulating tumor cells (CTCs) have served as an independent prognostic factor in the management of metastatic breast cancer (MBC). Through the enrichment of CTCs from peripheral blood, tumor cells can be acquired multiple times during therapy and provide a broad sample of tumor heterogeneity, thereby of... | Phenotypic Plasticity in Circulating Tumor Cells Is Associated with Poor Response to Therapy in Metastatic Breast Cancer Patients
Circulating tumor cells (CTCs) have served as an independent prognostic factor in the management of metastatic breast cancer (MBC). Through the enrichment of CTCs from peripheral blood, tum... | |
PMC10000982 | Prapenpuksiri Rungsa,Htoo Tint San,Boonchoo Sritularak,Chotima Böttcher,Eakachai Prompetchara,Chatchai Chaotham,Kittisak Likhitwitayawuid | Inhibitory Effect of Isopanduratin A on Adipogenesis: A Study of Possible Mechanisms | 27-02-2023 | fingerroot,Boesenbergia rotunda,obesity,adipocyte,isopanduratin A,AKT/GSK3β,AMPK-ACC,MAPKs,MCE | The root of Boesenbergia rotunda, a culinary plant commonly known as fingerroot, has previously been reported to possess anti-obesity activity, with four flavonoids identified as active principles, including pinostrobin, panduratin A, cardamonin, and isopanduratin A. However, the molecular mechanisms underlying the ant... | Inhibitory Effect of Isopanduratin A on Adipogenesis: A Study of Possible Mechanisms
The root of Boesenbergia rotunda, a culinary plant commonly known as fingerroot, has previously been reported to possess anti-obesity activity, with four flavonoids identified as active principles, including pinostrobin, panduratin A,... | |
PMC10000985 | Paul T. Winnard,Laura Morsberger,Raluca Yonescu,Liqun Jiang,Ying S. Zou,Venu Raman | Isogenic Cell Lines Derived from Specific Organ Metastases Exhibit Divergent Cytogenomic Aberrations | 23-02-2023 | karyotypes,isogenic metastatic cell lines,inter- and intra-cytogenomic heterogeneity,comparisons | Simple Summary Normal human cells have 22 pairs of chromosomes as well as 2 sex chromosomes for a total of 46 chromosomes; this normal karyotype is called diploidy (euploidy). On the other hand, aberrant numbers of chromosomes, i.e., gains and/or losses of chromosomes, have been found in most human cancer cells. This c... | Isogenic Cell Lines Derived from Specific Organ Metastases Exhibit Divergent Cytogenomic Aberrations
Normal human cells have 22 pairs of chromosomes as well as 2 sex chromosomes for a total of 46 chromosomes; this normal karyotype is called diploidy (euploidy). On the other hand, aberrant numbers of chromosomes, i.e.,... | |
PMC10000987 | Anna Stierschneider,Benjamin Neuditschko,Katrin Colleselli,Harald Hundsberger,Franz Herzog,Christoph Wiesner | Comparative and Temporal Characterization of LPS and Blue-Light-Induced TLR4 Signal Transduction and Gene Expression in Optogenetically Manipulated Endothelial Cells | 22-02-2023 | endothelial cells,Toll-like receptor 4,lipopolysaccharide,optogenetic control,pro-inflammatory proteins,quantitative mass-spectrometry,chemotaxis,transmigration | In endothelial cells (ECs), stimulation of Toll-like receptor 4 (TLR4) by the endotoxin lipopolysaccharide (LPS) induces the release of diverse pro-inflammatory mediators, beneficial in controlling bacterial infections. However, their systemic secretion is a main driver of sepsis and chronic inflammatory diseases. Sinc... | Comparative and Temporal Characterization of LPS and Blue-Light-Induced TLR4 Signal Transduction and Gene Expression in Optogenetically Manipulated Endothelial Cells
In endothelial cells (ECs), stimulation of Toll-like receptor 4 (TLR4) by the endotoxin lipopolysaccharide (LPS) induces the release of diverse pro-infla... | |
PMC10001005 | Jielin Deng,Yunqiu Jiang,Zhen Bouman Chen,June-Wha Rhee,Yingfeng Deng,Zhao V. Wang | Mitochondrial Dysfunction in Cardiac Arrhythmias | 21-02-2023 | mitochondrial dysfunction,arrhythmia,ATP supply,reactive oxygen species | Electrophysiological and structural disruptions in cardiac arrhythmias are closely related to mitochondrial dysfunction. Mitochondria are an organelle generating ATP, thereby satisfying the energy demand of the incessant electrical activity in the heart. In arrhythmias, the homeostatic supply–demand relationship is imp... | Mitochondrial Dysfunction in Cardiac Arrhythmias
Electrophysiological and structural disruptions in cardiac arrhythmias are closely related to mitochondrial dysfunction. Mitochondria are an organelle generating ATP, thereby satisfying the energy demand of the incessant electrical activity in the heart. In arrhythmias,... | |
PMC10001006 | Federica Torricelli,Elisabetta Sauta,Veronica Manicardi,Vincenzo Dario Mandato,Andrea Palicelli,Alessia Ciarrocchi,Gloria Manzotti | An Innovative Drug Repurposing Approach to Restrain Endometrial Cancer Metastatization | 03-03-2023 | drug repurposing,endometrial cancer,gene expression,metastasis,PI3K pathway | Background: Endometrial cancer (EC) is the most common gynecologic tumor and the world’s fourth most common cancer in women. Most patients respond to first-line treatments and have a low risk of recurrence, but refractory patients, and those with metastatic cancer at diagnosis, remain with no treatment options. Drug re... | An Innovative Drug Repurposing Approach to Restrain Endometrial Cancer Metastatization
Background: Endometrial cancer (EC) is the most common gynecologic tumor and the world’s fourth most common cancer in women. Most patients respond to first-line treatments and have a low risk of recurrence, but refractory patients, ... | |
PMC10001010 | Fei Liu,Yidan Gao,Jian Jiao,Yuyu Zhang,Jianda Li,Luogang Ding,Lin Zhang,Zhi Chen,Xiangbin Song,Guiwen Yang,Jiang Yu,Jiaqiang Wu | Upregulation of TLR4-Dependent ATP Production Is Critical for Glaesserella parasuis LPS-Mediated Inflammation | 26-02-2023 | G. parasuis LPS,inflammation,ATP,TLR4,P2X7R,acute inflammatory response,pharmacological target | Glaesserella parasuis (G. parasuis), an important pathogenic bacterium, cause Glässer’s disease, and has resulted in tremendous economic losses to the global swine industry. G. parasuis infection causes typical acute systemic inflammation. However, the molecular details of how the host modulates the acute inflammatory ... | Upregulation of TLR4-Dependent ATP Production Is Critical for Glaesserella parasuis LPS-Mediated Inflammation
Glaesserella parasuis (G. parasuis), an important pathogenic bacterium, cause Glässer’s disease, and has resulted in tremendous economic losses to the global swine industry. G. parasuis infection causes typica... | |
PMC10001020 | Jiaqin Chen,Dong Feng,Yuanyuan Lu,Yanjun Zhang,Hanxiang Jiang,Man Yuan,Yifan Xu,Jianjun Zou,Yubing Zhu,Jingjing Zhang,Chun Ge,Ying Wang | A Novel Phenazine Analog, CPUL1, Suppresses Autophagic Flux and Proliferation in Hepatocellular Carcinoma: Insight from Integrated Transcriptomic and Metabolomic Analysis | 05-03-2023 | CPUL1,hepatocellular carcinoma,transcriptomics,metabolomics,autophagy | Simple Summary CPUL1 exhibits antitumor properties against hepatocellular carcinoma (HCC), although the underlying mechanisms remain unclear. Our study provides a comprehensive overview of the properties and molecular mechanisms of CPUL1 anti-HCC using transcriptomics and metabolomics and highlights the significance of... | A Novel Phenazine Analog, CPUL1, Suppresses Autophagic Flux and Proliferation in Hepatocellular Carcinoma: Insight from Integrated Transcriptomic and Metabolomic Analysis
CPUL1 exhibits antitumor properties against hepatocellular carcinoma (HCC), although the underlying mechanisms remain unclear. Our study provides a ... | |
PMC10001022 | Haijie Xiao,Haifeng Zhu,Oliver Bögler,Fabiola Zakia Mónica,Alexander Y. Kots,Ferid Murad,Ka Bian | Soluble Guanylate Cyclase β1 Subunit Represses Human Glioblastoma Growth | 02-03-2023 | glioblastoma,sGCβ1,nucleus,p53,CDK6,integrin α6,G0 arrest | Simple Summary A marked reduction in soluble guanylyl cyclase β1 (sGCβ1) transcript is characteristic for human glioma specimens. Restoring the expression of sGCβ1 inhibited the aggressive course of glioblastoma in an orthotopic xenograft mouse model. The present study is the first to reveal that sGCβ1 migrated into th... | Soluble Guanylate Cyclase β1 Subunit Represses Human Glioblastoma Growth
A marked reduction in soluble guanylyl cyclase β1 (sGCβ1) transcript is characteristic for human glioma specimens. Restoring the expression of sGCβ1 inhibited the aggressive course of glioblastoma in an orthotopic xenograft mouse model. The prese... | |
PMC10001026 | Jaesung Lee,Seohyun Chung,Minkyu Hwang,Yeongkag Kwon,Seung Hyun Han,Sung Joong Lee | Estrogen Mediates the Sexual Dimorphism of GT1b-Induced Central Pain Sensitization | 06-03-2023 | GT1b,pain central sensitization,estrogen,sexual dimorphism,IL-1β | We have previously reported that the intrathecal (i.t.) administration of GT1b, a ganglioside, induces spinal cord microglia activation and central pain sensitization as an endogenous agonist of Toll-like receptor 2 on microglia. In this study, we investigated the sexual dimorphism of GT1b-induced central pain sensitiz... | Estrogen Mediates the Sexual Dimorphism of GT1b-Induced Central Pain Sensitization
We have previously reported that the intrathecal (i.t.) administration of GT1b, a ganglioside, induces spinal cord microglia activation and central pain sensitization as an endogenous agonist of Toll-like receptor 2 on microglia. In thi... | |
PMC10001027 | Florian Weber,Susanne Schueler-Toprak,Christa Buechler,Olaf Ortmann,Oliver Treeck | Chemerin and Chemokine-like Receptor 1 Expression in Ovarian Cancer Associates with Proteins Involved in Estrogen Signaling | 02-03-2023 | chemerin,chemokine-like receptor 1,estrogen-related receptors,ovarian cancer,overall survival,progression-free survival | Chemerin, a pleiotropic adipokine coded by the RARRES2 gene, has been reported to affect the pathophysiology of various cancer entities. To further approach the role of this adipokine in ovarian cancer (OC), intratumoral protein levels of chemerin and its receptor chemokine-like receptor 1 (CMKLR1) were examined by imm... | Chemerin and Chemokine-like Receptor 1 Expression in Ovarian Cancer Associates with Proteins Involved in Estrogen Signaling
Chemerin, a pleiotropic adipokine coded by the RARRES2 gene, has been reported to affect the pathophysiology of various cancer entities. To further approach the role of this adipokine in ovarian ... | |
PMC10001033 | Ana Sofia Coroadinha | Host Cell Restriction Factors Blocking Efficient Vector Transduction: Challenges in Lentiviral and Adeno-Associated Vector Based Gene Therapies | 24-02-2023 | gene therapy,lentiviral vectors,adeno-associated virus vectors,innate-immune response,host restriction factors,transduction | Gene therapy relies on the delivery of genetic material to the patient’s cells in order to provide a therapeutic treatment. Two of the currently most used and efficient delivery systems are the lentiviral (LV) and adeno-associated virus (AAV) vectors. Gene therapy vectors must successfully attach, enter uncoated, and e... | Host Cell Restriction Factors Blocking Efficient Vector Transduction: Challenges in Lentiviral and Adeno-Associated Vector Based Gene Therapies
Gene therapy relies on the delivery of genetic material to the patient’s cells in order to provide a therapeutic treatment. Two of the currently most used and efficient delive... | |
PMC10001044 | Albert Leng,Manuj Shah,Syed Ameen Ahmad,Lavienraj Premraj,Karin Wildi,Gianluigi Li Bassi,Carlos A. Pardo,Alex Choi,Sung-Min Cho | Pathogenesis Underlying Neurological Manifestations of Long COVID Syndrome and Potential Therapeutics | 06-03-2023 | COVID-19,SARS-CoV-2,long COVID,neurological manifestations,neurological complication,outcome,brain fog | The development of long-term symptoms of coronavirus disease 2019 (COVID-19) more than four weeks after primary infection, termed “long COVID” or post-acute sequela of COVID-19 (PASC), can implicate persistent neurological complications in up to one third of patients and present as fatigue, “brain fog”, headaches, cogn... | Pathogenesis Underlying Neurological Manifestations of Long COVID Syndrome and Potential Therapeutics
The development of long-term symptoms of coronavirus disease 2019 (COVID-19) more than four weeks after primary infection, termed “long COVID” or post-acute sequela of COVID-19 (PASC), can implicate persistent neurolo... | |
PMC10001046 | Nastaran Karimi,Seyed Javad Moghaddam | KRAS-Mutant Lung Cancer: Targeting Molecular and Immunologic Pathways, Therapeutic Advantages and Restrictions | 26-02-2023 | lung cancer,KRAS,molecular pathways,therapy | RAS mutations are among the most common oncogenic mutations in human cancers. Among RAS mutations, KRAS has the highest frequency and is present in almost 30% of non-small-cell lung cancer (NSCLC) patients. Lung cancer is the number one cause of mortality among cancers as a consequence of outrageous aggressiveness and ... | KRAS-Mutant Lung Cancer: Targeting Molecular and Immunologic Pathways, Therapeutic Advantages and Restrictions
RAS mutations are among the most common oncogenic mutations in human cancers. Among RAS mutations, KRAS has the highest frequency and is present in almost 30% of non-small-cell lung cancer (NSCLC) patients. L... | |
PMC10001068 | Jen-Hsiang T. Hsiao,Onur Tanglay,Anne A. Li,Aysha Y. G. Strobbe,Woojin Scott Kim,Glenda M. Halliday,YuHong Fu | Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy | 25-02-2023 | alpha-synuclein,multiple system atrophy,neurodegeneration,oligodendrocyte,oligodendrocyte progenitor cell | Multiple system atrophy (MSA) is a debilitating movement disorder with unknown etiology. Patients present characteristic parkinsonism and/or cerebellar dysfunction in the clinical phase, resulting from progressive deterioration in the nigrostriatal and olivopontocerebellar regions. MSA patients have a prodromal phase s... | Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy
Multiple system atrophy (MSA) is a debilitating movement disorder with unknown etiology. Patients present characteristic parkinsonism and/or cerebellar dysfunction in the clinical phase, resulting from progressive deterioration in the nigrostriatal and o... | |
PMC10001073 | Ziwei Liu,Hangyu Li,Qianqian Liu,Yangyang Feng,Daiyan Wu,Xinnan Zhang,Linzi Zhang,Sheng Li,Feng Tang,Qun Liu,Xiaonong Yang,Haibo Feng | Ultrasonic Treatment Enhances the Antioxidant and Immune-Stimulatory Properties of the Polysaccharide from Sinopodophyllum hexandrum Fruit | 21-02-2023 | ultrasonic,carbohydrate,structural characterization,antioxidant,immunomodulatory effect | We aimed to assess the potential of ultrasonic treatment on the processing of polysaccharides as functional foods or food additives. The polysaccharide from Sinopodophyllum hexandrum fruit (SHP, 52.46 kDa, 1.91 nm) was isolated and purified. SHP was treated with various levels of ultrasound (250 W and 500 W), resulting... | Ultrasonic Treatment Enhances the Antioxidant and Immune-Stimulatory Properties of the Polysaccharide from Sinopodophyllum hexandrum Fruit
We aimed to assess the potential of ultrasonic treatment on the processing of polysaccharides as functional foods or food additives. The polysaccharide from Sinopodophyllum hexandr... | |
PMC10001075 | Wan Norizzati Wan Mohamad Zamri,Nazihah Mohd Yunus,Ahmad Aizat Abdul Aziz,Ninie Nadia Zulkipli,Sarina Sulong | Perspectives on the Application of Cytogenomic Approaches in Chronic Lymphocytic Leukaemia | 03-03-2023 | cytogenomics,chronic lymphocytic leukaemia,microarray | Chronic lymphocytic leukaemia (CLL) is a haematological malignancy characterised by the accumulation of monoclonal mature B lymphocytes (positive for CD5+ and CD23+) in peripheral blood, bone marrow, and lymph nodes. Although CLL is reported to be rare in Asian countries compared to Western countries, the disease cours... | Perspectives on the Application of Cytogenomic Approaches in Chronic Lymphocytic Leukaemia
Chronic lymphocytic leukaemia (CLL) is a haematological malignancy characterised by the accumulation of monoclonal mature B lymphocytes (positive for CD5+ and CD23+) in peripheral blood, bone marrow, and lymph nodes. Although CL... | |
PMC10001080 | Vladimir O. Sigin,Alexey I. Kalinkin,Alexandra F. Nikolaeva,Ekaterina O. Ignatova,Ekaterina B. Kuznetsova,Galina G. Chesnokova,Nikolai V. Litviakov,Matvey M. Tsyganov,Marina K. Ibragimova,Ilya I. Vinogradov,Maxim I. Vinogradov,Igor Y. Vinogradov,Dmitry V. Zaletaev,Marina V. Nemtsova,Sergey I. Kutsev,Alexander S. Tanas,... | DNA Methylation and Prospects for Predicting the Therapeutic Effect of Neoadjuvant Chemotherapy for Triple-Negative and Luminal B Breast Cancer | 06-03-2023 | breast cancer,DNA methylation,RRBS,MSRE-qPCR,predictive markers,neoadjuvant chemotherapy | Simple Summary Breast cancer (BC) is a group of diseases heterogeneous in morphology, progression, survival, and response to therapy. Although BC is among the most exhaustively studied cancers, there is still a lack of molecular markers to predict its response to neoadjuvant chemotherapy (NACT). Tumor development is de... | DNA Methylation and Prospects for Predicting the Therapeutic Effect of Neoadjuvant Chemotherapy for Triple-Negative and Luminal B Breast Cancer
Breast cancer (BC) is a group of diseases heterogeneous in morphology, progression, survival, and response to therapy. Although BC is among the most exhaustively studied cance... | |
PMC10001084 | Andressa Roehrig Volpe-Fix,Elias de França,Jean Carlos Silvestre,Ronaldo Vagner Thomatieli-Santos | The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise: A Review | 21-02-2023 | flavonoids,physical exercise,inflammation,muscle damage | Food bioactive compounds (FBC) comprise a vast class of substances, including polyphenols, with different chemical structures, and they exert physiological effects on individuals who consume them, such as antioxidant and anti-inflammatory action. The primary food sources of the compounds are fruits, vegetables, wines, ... | The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise: A Review
Food bioactive compounds (FBC) comprise a vast class of substances, including polyphenols, with different chemical structures, and they exert physiological effects on individuals who consume them, suc... | |
PMC10001085 | Albano Toska,Nikita Modi,Lin-Feng Chen | RUNX3 Meets the Ubiquitin-Proteasome System in Cancer | 24-02-2023 | E3 ligase,proteasomal degradation,RUNX3,tumor suppressor,ubiquitination | RUNX3 is a transcription factor with regulatory roles in cell proliferation and development. While largely characterized as a tumor suppressor, RUNX3 can also be oncogenic in certain cancers. Many factors account for the tumor suppressor function of RUNX3, which is reflected by its ability to suppress cancer cell proli... | RUNX3 Meets the Ubiquitin-Proteasome System in Cancer
RUNX3 is a transcription factor with regulatory roles in cell proliferation and development. While largely characterized as a tumor suppressor, RUNX3 can also be oncogenic in certain cancers. Many factors account for the tumor suppressor function of RUNX3, which is... | |
PMC10001097 | Jiahao Li,Lansi Chen,Jingjing Pang,Chunxiu Yang,Wen Xie,Guoyan Shen,Hongshan Chen,Xiaoyi Li,Shu-Yuan Xiao,Yueying Li | Autophagy-Related Gene WD Repeat Domain 45B Promotes Tumor Proliferation and Migration of Hepatocellular Carcinoma through the Akt/mTOR Signaling Pathway | 27-02-2023 | hepatocellular carcinoma,autophagy,prognosis,WDR45B,Akt/mTOR signaling pathway | Hepatocellular carcinoma (HCC) is a highly aggressive malignant tumor. It has been found that autophagy plays a role both as a tumor promoter and inhibitor in HCC carcinogenesis. However, the mechanism behind is still unveiled. This study aims to explore the functions and mechanism of the key autophagy-related proteins... | Autophagy-Related Gene WD Repeat Domain 45B Promotes Tumor Proliferation and Migration of Hepatocellular Carcinoma through the Akt/mTOR Signaling Pathway
Hepatocellular carcinoma (HCC) is a highly aggressive malignant tumor. It has been found that autophagy plays a role both as a tumor promoter and inhibitor in HCC ca... | |
PMC10001101 | Jessica Bamba-Funck,Emmanuelle E. Fabre,Marianne Kambouchner,Olivier Schischmanoff | Performance Characteristics of Oncomine Focus Assay for Theranostic Analysis of Solid Tumors, A (21-Months) Real-Life Study | 01-03-2023 | next generation sequencing (NGS),solid tumors,single nucleotide variation (SNV),copy number variation (CNV),fusion transcript,long-term follow-up | Next generation sequencing analysis is crucial for therapeutic decision in various solid tumor contexts. The sequencing method must remain accurate and robust throughout the instrument lifespan allowing the biological validation of patients’ results. This study aims to evaluate the long-term sequencing performances of ... | Performance Characteristics of Oncomine Focus Assay for Theranostic Analysis of Solid Tumors, A (21-Months) Real-Life Study
Next generation sequencing analysis is crucial for therapeutic decision in various solid tumor contexts. The sequencing method must remain accurate and robust throughout the instrument lifespan a... | |
PMC10001105 | Yohann Dabi,Amélia Favier,Léo Razakamanantsoa,Léa Delbos,Mathieu Poilblanc,Philippe Descamps,Francois Golfier,Cyril Touboul,Sofiane Bendifallah,Emile Daraï | Insight on Non-Coding RNAs from Biofluids in Ovarian Tumors | 28-02-2023 | ovarian tumor,non-coding RNA,borderline ovarian tumor,ovarian cancer | Simple Summary Ovarian cancer is the most lethal gynecologic cancer since it is often diagnosed at advanced stages. Current tools for diagnosis are currently insufficient and include physical examination, ultrasound and pelvic magnetic resonance imaging, as well as algorithms combining thoraco-abdomino-pelvic scans and... | Insight on Non-Coding RNAs from Biofluids in Ovarian Tumors
Ovarian cancer is the most lethal gynecologic cancer since it is often diagnosed at advanced stages. Current tools for diagnosis are currently insufficient and include physical examination, ultrasound and pelvic magnetic resonance imaging, as well as algorith... | |
PMC10001109 | Kholoud Almaabdi,Zareen Ahmad,Sindhu R. Johnson | Advanced Autoantibody Testing in Systemic Sclerosis | 23-02-2023 | systemic sclerosis,scleroderma,antibodies | Systemic sclerosis is a systemic autoimmune rheumatic disease characterized by immune abnormalities, leading to vasculopathy and fibrosis. Autoantibody testing has become an increasingly important part of diagnosis and prognostication. Clinicians have been limited to antinuclear antibody (ANA), antitopoisomerase I (als... | Advanced Autoantibody Testing in Systemic Sclerosis
Systemic sclerosis is a systemic autoimmune rheumatic disease characterized by immune abnormalities, leading to vasculopathy and fibrosis. Autoantibody testing has become an increasingly important part of diagnosis and prognostication. Clinicians have been limited to... | |
PMC10001116 | Giovanna Barbero,Roberta Zuntini,Pamela Magini,Laura Desiderio,Michela Bonaguro,Anna Myriam Perrone,Daniela Rubino,Mina Grippa,Antonio De Leo,Claudio Ceccarelli,Lea Godino,Sara Miccoli,Simona Ferrari,Donatella Santini,Pierandrea De Iaco,Claudio Zamagni,Giovanni Innella,Daniela Turchetti | Characterization of BRCA Deficiency in Ovarian Cancer | 28-02-2023 | BRCA1,BRCA2,ovarian cancer | Simple Summary Ovarian cancer (OC) is a highly lethal malignancy. Major improvements in treatment are expected from the identification of molecular features that may predict outcome or be used as therapeutic targets. Among genetic defects relevant for OC are those of BRCA1 and BRCA2 genes. Indeed, at least 20% of OC pa... | Characterization of BRCA Deficiency in Ovarian Cancer
Ovarian cancer (OC) is a highly lethal malignancy. Major improvements in treatment are expected from the identification of molecular features that may predict outcome or be used as therapeutic targets. Among genetic defects relevant for OC are those of BRCA1 and BR... | |
PMC10001118 | Yinuo Wang,Gergana Dobreva | Epigenetics in LMNA-Related Cardiomyopathy | 01-03-2023 | nuclear lamina,lamin A/C,LMNA,cardiomyopathy,epigenetics,chromatin architecture,stem cells | Mutations in the gene for lamin A/C (LMNA) cause a diverse range of diseases known as laminopathies. LMNA-related cardiomyopathy is a common inherited heart disease and is highly penetrant with a poor prognosis. In the past years, numerous investigations using mouse models, stem cell technologies, and patient samples h... | Epigenetics in LMNA-Related Cardiomyopathy
Mutations in the gene for lamin A/C (LMNA) cause a diverse range of diseases known as laminopathies. LMNA-related cardiomyopathy is a common inherited heart disease and is highly penetrant with a poor prognosis. In the past years, numerous investigations using mouse models, s... | |
PMC10001120 | Diane Frankel,Isabelle Nanni,L’Houcine Ouafik,Laurent Greillier,Hervé Dutau,Philippe Astoul,Laurent Daniel,Elise Kaspi,Patrice Roll | Cytological Samples: An Asset for the Diagnosis and Therapeutic Management of Patients with Lung Cancer | 27-02-2023 | cytological sample,cytopathology,lung cancer,adenocarcinoma,PD-L1,molecular testing,NGS,immunocytochemistry | Background: Lung cancer has become the leading cause of cancer death for men and women. Most patients are diagnosed at an advanced stage when surgery is no longer a therapeutic option. At this stage, cytological samples are often the less invasive source for diagnosis and the determination of predictive markers. We ass... | Cytological Samples: An Asset for the Diagnosis and Therapeutic Management of Patients with Lung Cancer
Background: Lung cancer has become the leading cause of cancer death for men and women. Most patients are diagnosed at an advanced stage when surgery is no longer a therapeutic option. At this stage, cytological sam... | |
PMC10001121 | Mariana de Moura e Dias,Vinícius da Silva Duarte,Lúcio Flávio Macedo Mota,Gabriela de Cássia Ávila Alpino,Sandra Aparecida dos Reis Louzano,Lisiane Lopes da Conceição,Hilário Cuquetto Mantovanie,Solange Silveira Pereira,Leandro Licursi Oliveira,Tiago Antônio de Oliveira Mendes,Davide Porcellato,Maria do Carmo Gouveia P... | Lactobacillus gasseri LG-G12 Restores Gut Microbiota and Intestinal Health in Obesity Mice on Ceftriaxone Therapy | 03-03-2023 | Lactobacillus gasseri LG-G12,intestinal health,ceftriaxone,gut microbiota,obesity | Gut microbiota imbalance is associated with the occurrence of metabolic diseases such as obesity. Thus, its modulation is a promising strategy to restore gut microbiota and improve intestinal health in the obese. This paper examines the role of probiotics, antimicrobials, and diet in modulating gut microbiota and impro... | Lactobacillus gasseri LG-G12 Restores Gut Microbiota and Intestinal Health in Obesity Mice on Ceftriaxone Therapy
Gut microbiota imbalance is associated with the occurrence of metabolic diseases such as obesity. Thus, its modulation is a promising strategy to restore gut microbiota and improve intestinal health in the... | |
PMC10001133 | Łukasz Witucki,Hieronim Jakubowski | Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice | 26-02-2023 | APP,amyloid beta,Pon1−/−5xFAD mouse model,N2a-APPswe cells,Pon1,homocysteine thiolactone,Phf8,H4K20me1,mTOR,autophagy | Paraoxonase 1 (PON1), a homocysteine (Hcy)-thiolactone detoxifying enzyme, has been associated with Alzheimer’s disease (AD), suggesting that PON1 plays an important protective role in the brain. To study the involvement of PON1 in the development of AD and to elucidate the mechanism involved, we generated a new mouse ... | Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice
Paraoxonase 1 (PON1), a homocysteine (Hcy)-thiolactone detoxifying enzyme, has been associated with Alzheimer’s disease (AD), suggesting that PON1 plays an important protective role in the brain. To study ... | |
PMC10001145 | Maik Luu,Burkhard Schütz,Matthias Lauth,Alexander Visekruna | The Impact of Gut Microbiota-Derived Metabolites on the Tumor Immune Microenvironment | 03-03-2023 | tumor microenvironment (TME),commensal bacteria,intratumoral microbiota,oncobiome,microbiota-derived metabolites,cancer immunotherapy | Simple Summary The tumor microenvironment (TME) comprises various non-malignant cells and soluble factors that surround cancer cells and which have mostly a pro-tumorigenic role. Growing evidence indicates that commensal bacteria are involved in the pathogenesis and progression but also in the suppression of various hu... | The Impact of Gut Microbiota-Derived Metabolites on the Tumor Immune Microenvironment
The tumor microenvironment (TME) comprises various non-malignant cells and soluble factors that surround cancer cells and which have mostly a pro-tumorigenic role. Growing evidence indicates that commensal bacteria are involved in th... | |
PMC10001158 | Ayse Sedef Köseer,Simona Di Gaetano,Claudia Arndt,Michael Bachmann,Anna Dubrovska | Immunotargeting of Cancer Stem Cells | 05-03-2023 | cancer stem cells,CSC,bsAB,CAR-T cells,cancer vaccines,immunotherapy | Simple Summary Tumor cells from the same specimen are functionally heterogeneous. Cancer stem cells (CSCs) are populations of tumor cells with self-renewal and differentiation properties. CSCs are found in nearly all solid and hematological tumors and are characterized by various surface or intracellular markers. These... | Immunotargeting of Cancer Stem Cells
Tumor cells from the same specimen are functionally heterogeneous. Cancer stem cells (CSCs) are populations of tumor cells with self-renewal and differentiation properties. CSCs are found in nearly all solid and hematological tumors and are characterized by various surface or intra... | |
PMC10001161 | Tristram A. J. Ryan,Luke A. J. O’Neill | An Emerging Role for Type I Interferons as Critical Regulators of Blood Coagulation | 28-02-2023 | type I interferons,blood coagulation,IFN-α,IFN-β,thrombin,PARs,haemostasis,thrombosis,tissue factor,SLE,APS,COVID-19,cGAS-STING,neutrophil extracellular traps,FXII | Type I interferons (IFNs) are central mediators of anti-viral and anti-bacterial host defence. Detection of microbes by innate immune cells via pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and cGAS-STING, induces the expression of type I IFN-stimulated genes. Primarily comprising the cytok... | An Emerging Role for Type I Interferons as Critical Regulators of Blood Coagulation
Type I interferons (IFNs) are central mediators of anti-viral and anti-bacterial host defence. Detection of microbes by innate immune cells via pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and cGAS-STING, ... |