akramRedjdal/mdiec-ner · Datasets at Hugging Face

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MDIEC/20221103_175	In primary care pediatric settings, the EPDS and its shorter subscales have potential for use as effective depression screening tools.	T1 method 3 34 primary care pediatric settings T2 method 40 44 EPDS T3 method 107 133 depression screening tools R1 hyponym_of Arg1:T2 Arg2:T3	[ "In", "primary", "care", "pediatric", "settings", ",", "the", "EPDS", "and", "its", "shorter", "subscales", "have", "potential", "for", "use", "as", "effective", "depression", "screening", "tools", "." ]	[ 0, 3, 11, 16, 26, 34, 36, 40, 45, 49, 53, 61, 71, 76, 86, 90, 94, 97, 107, 118, 128, 133 ]	[ 2, 10, 15, 25, 34, 35, 39, 44, 48, 52, 60, 70, 75, 85, 89, 93, 96, 106, 117, 127, 133, 134 ]	[ "O", "B-method", "I-method", "I-method", "I-method", "O", "O", "B-method", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-method", "I-method", "I-method", "O" ]	[ 0, 9, 10, 10, 10, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0 ]
MDIEC/33743882	Register-based metrics of years lived with disability associated with mental and substance use disorders: a register-based cohort study in Denmark. BACKGROUND Mental disorders account for a substantial proportion of the years lived with disability (YLDs) globally. These estimates have generally been calculated top down...	T0 disease 70 104 mental and substance use disorders T1 Health_factors 26 53 years lived with disability T3 method 108 135 register-based cohort study T4 method 0 22 Register-based metrics T5 disease 159 175 Mental disorders T7 Health_factors 220 247 years lived with disability T8 disease 462 496 mental and substance u...	[ "Register", "-", "based", "metrics", "of", "years", "lived", "with", "disability", "associated", "with", "mental", "and", "substance", "use", "disorders", ":", "a", "register", "-", "based", "cohort", "study", "in", "Denmark", ".", "BACKGROUND", "Mental", "dis...	[ 0, 8, 9, 15, 23, 26, 32, 38, 43, 54, 65, 70, 77, 81, 91, 95, 104, 106, 108, 116, 117, 123, 130, 136, 139, 146, 148, 159, 166, 176, 184, 188, 190, 202, 213, 216, 220, 226, 232, 237, 248, 249, 253, 255, 263, 265, 271, 281, ...	[ 8, 9, 14, 22, 25, 31, 37, 42, 53, 64, 69, 76, 80, 90, 94, 104, 105, 107, 116, 117, 122, 129, 135, 138, 146, 147, 158, 165, 175, 183, 187, 189, 201, 212, 215, 219, 225, 231, 236, 247, 249, 253, 254, 263, 264, 270, 280, 285,...	[ "B-method", "I-method", "I-method", "I-method", "O", "B-Health_factors", "I-Health_factors", "I-Health_factors", "I-Health_factors", "O", "O", "B-disease", "I-disease", "I-disease", "I-disease", "I-disease", "O", "O", "B-method", "I-method", "I-method", "I-method", "I-met...	[ 9, 10, 10, 10, 0, 1, 2, 2, 2, 0, 0, 3, 4, 4, 4, 4, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, ...
MDIEC/15292631	QT interval and QT dispersion in eating disorders. BACKGROUND Eating disorders are thought to be risk factors for cardiac sudden death secondary to arrhythmia. Results in previous studies on QT interval and QT dispersion, markers of fatal arrhythmia, have been inconsistent. METHODS We prospectively examined 179 femal...	T0 disease 33 49 eating disorders T1 signs 0 11 QT interval T2 disease 62 78 Eating disorders T3 disease 114 134 cardiac sudden death T4 disease 148 158 arrhythmia T6 disease 233 249 fatal arrhythmia T8 signs 191 202 QT interval T11 Health_factors 368 371 old T12 method 403 418 DSM-IV criteria T14 Health_factors 466 47...	[ "QT", "interval", "and", "QT", "dispersion", "in", "eating", "disorders", ".", "BACKGROUND", "Eating", "disorders", "are", "thought", "to", "be", "risk", "factors", "for", "cardiac", "sudden", "death", "secondary", "to", "arrhythmia", ".", "Results", "in", "pr...	[ 0, 3, 12, 16, 19, 30, 33, 40, 49, 51, 62, 69, 79, 83, 91, 94, 97, 102, 110, 114, 122, 129, 135, 145, 148, 158, 160, 168, 171, 180, 188, 191, 194, 203, 207, 210, 220, 222, 230, 233, 239, 249, 251, 256, 261, 273, 277, 285, ...	[ 2, 11, 15, 18, 29, 32, 39, 49, 50, 61, 68, 78, 82, 90, 93, 96, 101, 109, 113, 121, 128, 134, 144, 147, 158, 159, 167, 170, 179, 187, 190, 193, 202, 206, 209, 220, 221, 229, 232, 238, 249, 250, 255, 260, 273, 274, 284, 287,...	[ "B-signs", "I-signs", "O", "B-signs", "I-signs", "O", "B-disease", "I-disease", "O", "O", "B-disease", "I-disease", "O", "O", "O", "O", "O", "O", "O", "B-disease", "I-disease", "I-disease", "O", "O", "B-disease", "O", "O", "O", "O", "O", "O", "B-signs", ...	[ 15, 16, 0, 15, 16, 0, 3, 4, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 3, 0, 0, 0, 0, 0, 0, 15, 16, 0, 15, 16, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 3, 4, 0, 0, 0, 0, 0, 0, 1, 0, ...
MDIEC/20221103_11	RESULTS: Depressed subjects who were not treated with antidepressant medications had lower levels of VZV-CMI following administration of zoster vaccine than nondepressed controls or depressed subjects receiving antidepressants even when antidepressant medications failed to alter depressive symptom severity (P<.005).	T1 disease 9 18 Depressed T3 drug 54 80 antidepressant medications T4 drug 237 263 antidepressant medications T6 drug 137 151 zoster vaccine T9 disease 182 191 depressed T10 drug 211 226 antidepressants T11 disease 280 298 depressive symptom T5 physiology 101 108 VZV-CMI R1 characteristic_of Arg1:T5 Arg2:T1 R2 treatme...	[ "RESULTS", ":", "Depressed", "subjects", "who", "were", "not", "treated", "with", "antidepressant", "medications", "had", "lower", "levels", "of", "VZV", "-", "CMI", "following", "administration", "of", "zoster", "vaccine", "than", "nondepressed", "controls", "or"...	[ 0, 7, 9, 19, 28, 32, 37, 41, 49, 54, 69, 81, 85, 91, 98, 101, 104, 105, 109, 119, 134, 137, 144, 152, 157, 170, 179, 182, 192, 201, 211, 227, 232, 237, 252, 264, 271, 274, 280, 291, 299, 308, 309, 310, 311, 312, 315, 316 ]	[ 7, 8, 18, 27, 31, 36, 40, 48, 53, 68, 80, 84, 90, 97, 100, 104, 105, 108, 118, 133, 136, 143, 151, 156, 169, 178, 181, 191, 200, 210, 226, 231, 236, 251, 263, 270, 273, 279, 290, 298, 307, 309, 310, 311, 312, 315, 316, 317...	[ "O", "O", "B-disease", "O", "O", "O", "O", "O", "O", "B-drug", "I-drug", "O", "O", "O", "O", "B-physiology", "I-physiology", "I-physiology", "O", "O", "O", "B-drug", "I-drug", "O", "O", "O", "O", "B-disease", "O", "O", "B-drug", "O", "O", "B-drug", ...	[ 0, 0, 3, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 11, 12, 12, 0, 0, 0, 5, 6, 0, 0, 0, 0, 3, 0, 0, 5, 0, 0, 5, 6, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0 ]
MDIEC/32348643	Association between Mental Disorders and Subsequent Medical Conditions. BACKGROUND Persons with mental disorders are at a higher risk than the general population for the subsequent development of certain medical conditions. METHODS We used a population-based cohort from Danish national registries that included data o...	T1 disease 20 36 Mental Disorders T2 disease 96 112 mental disorders T3 disease 505 521 mental disorders T4 disease 722 738 mental disorders T5 disease 822 838 mental disorders T6 disease 1007 1022 mental disorder T7 disease 1168 1183 mental disorder T8 disease 1270 1286 mental disorders T9 disease 1364 1379 mental dis...	[ "Association", "between", "Mental", "Disorders", "and", "Subsequent", "Medical", "Conditions", ".", "BACKGROUND", "Persons", "with", "mental", "disorders", "are", "at", "a", "higher", "risk", "than", "the", "general", "population", "for", "the", "subsequent", "dev...	[ 0, 12, 20, 27, 37, 41, 52, 60, 70, 72, 83, 91, 96, 103, 113, 117, 120, 122, 129, 134, 139, 143, 151, 162, 166, 170, 181, 193, 196, 204, 212, 222, 226, 234, 237, 242, 244, 254, 255, 261, 268, 273, 280, 289, 300, 305, 314, 3...	[ 11, 19, 26, 36, 40, 51, 59, 70, 71, 82, 90, 95, 102, 112, 116, 119, 121, 128, 133, 138, 142, 150, 161, 165, 169, 180, 192, 195, 203, 211, 222, 223, 233, 236, 241, 243, 254, 255, 260, 267, 272, 279, 288, 299, 304, 313, 318, ...	[ "O", "O", "B-disease", "I-disease", "O", "O", "B-disease", "I-disease", "O", "O", "O", "O", "B-disease", "I-disease", "O", "O", "O", "O", "O", "O", "O", "B-Health_factors", "I-Health_factors", "O", "O", "O", "O", "O", "O", "B-disease", "I-disease", "O", ...	[ 0, 0, 3, 4, 0, 0, 3, 4, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, ...
MDIEC/20221103_47	Imaging and postmortem brain studies in depressed human subjects, in combination with animal behavioral models of depression, have identified a number of different cellular events, intracellular signaling pathways, proteins, and target genes that are modulated by stress and are potentially vital mediators of antidepres...	T1 method 0 36 Imaging and postmortem brain studies T2 disease 40 49 depressed T3 method 86 110 animal behavioral models T4 disease 114 124 depression T6 physiology 181 213 intracellular signaling pathways T9 disease 264 270 stress T11 physiology 310 331 antidepressant action T5 disease 164 179 cellular events R1 assoc...	[ "Imaging", "and", "postmortem", "brain", "studies", "in", "depressed", "human", "subjects", ",", "in", "combination", "with", "animal", "behavioral", "models", "of", "depression", ",", "have", "identified", "a", "number", "of", "different", "cellular", "events", ...	[ 0, 8, 12, 23, 29, 37, 40, 50, 56, 64, 66, 69, 81, 86, 93, 104, 111, 114, 124, 126, 131, 142, 144, 151, 154, 164, 173, 179, 181, 195, 205, 213, 215, 223, 225, 229, 236, 242, 247, 251, 261, 264, 271, 275, 279, 291, 297, 307,...	[ 7, 11, 22, 28, 36, 39, 49, 55, 64, 65, 68, 80, 85, 92, 103, 110, 113, 124, 125, 130, 141, 143, 150, 153, 163, 172, 179, 180, 194, 204, 213, 214, 223, 224, 228, 235, 241, 246, 250, 260, 263, 270, 274, 278, 290, 296, 306, 30...	[ "B-method", "I-method", "I-method", "I-method", "I-method", "O", "B-disease", "B-Health_factors", "O", "O", "O", "O", "O", "B-method", "I-method", "I-method", "O", "B-disease", "O", "O", "O", "O", "O", "O", "O", "B-disease", "I-disease", "O", "B-physiology", ...	[ 9, 10, 10, 10, 10, 0, 3, 1, 0, 0, 0, 0, 0, 9, 10, 10, 0, 3, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 11, 12, 12, 0, 0, 0, 0, 0, 7, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 11, 12, 0 ]
MDIEC/20221103_181	RESULTS: RMT treatment was associated with significant clinical improvement in depression scores at 8th week (Hamilton depression rating scale scores (Mean +- SEM) from 21.5 +- 2.44 to 14.31 +- 2.25, p <= 0.05).	T1 method 9 22 RMT treatment T2 disease 79 89 depression T3 method 110 149 Hamilton depression rating scale scores R1 treatment_for Arg1:T1 Arg2:T2 T4 method 159 162 SEM R2 help_diagnose Arg1:T3 Arg2:T2	[ "RESULTS", ":", "RMT", "treatment", "was", "associated", "with", "significant", "clinical", "improvement", "in", "depression", "scores", "at", "8th", "week", "(", "Hamilton", "depression", "rating", "scale", "scores", "(", "Mean", "+", "-", "SEM", ")", "from",...	[ 0, 7, 9, 13, 23, 27, 38, 43, 55, 64, 76, 79, 90, 97, 100, 104, 109, 110, 119, 130, 137, 143, 150, 151, 156, 157, 159, 162, 164, 169, 171, 172, 174, 175, 177, 178, 179, 182, 185, 187, 188, 191, 192, 194, 195, 196, 198, 200,...	[ 7, 8, 12, 22, 26, 37, 42, 54, 63, 75, 78, 89, 96, 99, 103, 108, 110, 118, 129, 136, 142, 149, 151, 155, 157, 158, 162, 163, 168, 171, 172, 173, 175, 176, 178, 179, 181, 184, 187, 188, 190, 192, 193, 195, 196, 198, 199, 201...	[ "O", "O", "B-method", "I-method", "O", "O", "O", "O", "O", "O", "O", "B-disease", "O", "O", "O", "O", "O", "B-method", "I-method", "I-method", "I-method", "I-method", "O", "O", "O", "O", "B-method", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...	[ 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
MDIEC/20221103_129	Controversy: Repetitive transcranial magnetic stimulation or transcranial direct current stimulation shows efficacy in treating psychiatric diseases (depression, mania, schizophrenia, obsessive-complusive disorder, panic, posttraumatic stress disorder).	T1 method 13 57 Repetitive transcranial magnetic stimulation T2 disease 128 148 psychiatric diseases T3 disease 150 160 depression T4 disease 162 167 mania T5 disease 169 182 schizophrenia T6 disease 184 213 obsessive-complusive disorder T7 disease 215 220 panic T8 disease 222 251 posttraumatic stress disorder T9 metho...	[ "Controversy", ":", "Repetitive", "transcranial", "magnetic", "stimulation", "or", "transcranial", "direct", "current", "stimulation", "shows", "efficacy", "in", "treating", "psychiatric", "diseases", "(", "depression", ",", "mania", ",", "schizophrenia", ",", "obsess...	[ 0, 11, 13, 24, 37, 46, 58, 61, 74, 81, 89, 101, 107, 116, 119, 128, 140, 149, 150, 160, 162, 167, 169, 182, 184, 193, 194, 205, 213, 215, 220, 222, 236, 243, 251, 252 ]	[ 11, 12, 23, 36, 45, 57, 60, 73, 80, 88, 100, 106, 115, 118, 127, 139, 148, 150, 160, 161, 167, 168, 182, 183, 193, 194, 204, 213, 214, 220, 221, 235, 242, 251, 252, 253 ]	[ "O", "O", "B-method", "I-method", "I-method", "I-method", "O", "B-method", "I-method", "I-method", "I-method", "O", "O", "O", "O", "B-disease", "I-disease", "O", "B-disease", "O", "B-disease", "O", "B-disease", "O", "B-disease", "I-disease", "I-disease", "I-dise...	[ 0, 0, 9, 10, 10, 10, 0, 9, 10, 10, 10, 0, 0, 0, 0, 3, 4, 0, 3, 0, 3, 0, 3, 0, 3, 4, 4, 4, 0, 3, 0, 3, 4, 4, 0, 0 ]
MDIEC/11187420	Psychopharmacologic treatment strategies for depression, bipolar disorder, and schizophrenia. Patients with serious psychiatric disorders are frequently treated by primary care physicians, who may have difficulty keeping up with recent advances in psychiatry. This paper presents an updated synopsis for three major psyc...	T0 disease 45 55 depression T1 disease 57 73 bipolar disorder T2 disease 79 92 schizophrenia T3 method 0 40 Psychopharmacologic treatment strategies T4 disease 108 137 serious psychiatric disorders T6 Health_factors 164 187 primary care physicians T7 method 248 258 psychiatry T9 disease 316 337 psychiatric illnesses T1...	[ "Psychopharmacologic", "treatment", "strategies", "for", "depression", ",", "bipolar", "disorder", ",", "and", "schizophrenia", ".", "Patients", "with", "serious", "psychiatric", "disorders", "are", "frequently", "treated", "by", "primary", "care", "physicians", ",", ...	[ 0, 20, 30, 41, 45, 55, 57, 65, 73, 75, 79, 92, 94, 103, 108, 116, 128, 138, 142, 153, 161, 164, 172, 177, 187, 189, 193, 197, 202, 213, 221, 224, 229, 236, 245, 248, 258, 260, 265, 271, 280, 283, 291, 300, 304, 310, 316, 3...	[ 19, 29, 40, 44, 55, 56, 64, 73, 74, 78, 92, 93, 102, 107, 115, 127, 137, 141, 152, 160, 163, 171, 176, 187, 188, 192, 196, 201, 212, 220, 223, 228, 235, 244, 247, 258, 259, 264, 270, 279, 282, 290, 299, 303, 309, 315, 327, ...	[ "B-method", "I-method", "I-method", "O", "B-disease", "O", "B-disease", "I-disease", "O", "O", "B-disease", "O", "O", "O", "B-disease", "I-disease", "I-disease", "O", "O", "O", "O", "B-Health_factors", "I-Health_factors", "I-Health_factors", "O", "O", "O", "O", ...	[ 9, 10, 10, 0, 3, 0, 3, 4, 0, 0, 3, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 3, 4, 0, 3, 4, 0, 0, 3, 0, 0, 0, 0, 0, 9, ...
MDIEC/34416346	Sub-regional hippocampal volumes in first-episode drug-naive major depression disorder. Hippocampal volume reduction was reported to underlie depressive symptomatology, however, the evidence to date remains inconsistent. For the complex intrinsic organization of hippocampus, the hippocampal volumes can be further divid...	T1 disease 36 86 first-episode drug-naive major depression disorder T2 disease 142 167 depressive symptomatology T3 disease 469 494 major depressive disorder T4 disease 496 499 MDD T5 disease 542 570 first-episode drug-naive MDD T6 disease 1002 1005 MDD T7 disease 1088 1091 MDD T8 disease 1304 1307 MDD T9 disease 1401 ...	[ "Sub", "-", "regional", "hippocampal", "volumes", "in", "first", "-", "episode", "drug", "-", "naive", "major", "depression", "disorder", ".", "Hippocampal", "volume", "reduction", "was", "reported", "to", "underlie", "depressive", "symptomatology", ",", "however"...	[ 0, 3, 4, 13, 25, 33, 36, 41, 42, 50, 54, 55, 61, 67, 78, 86, 88, 100, 107, 117, 121, 130, 133, 142, 153, 167, 169, 176, 178, 182, 191, 194, 199, 207, 219, 221, 225, 229, 237, 247, 260, 263, 274, 276, 280, 292, 300, 304, ...	[ 3, 4, 12, 24, 32, 35, 41, 42, 49, 54, 55, 60, 66, 77, 86, 87, 99, 106, 116, 120, 129, 132, 141, 152, 167, 168, 176, 177, 181, 190, 193, 198, 206, 219, 220, 224, 228, 236, 246, 259, 262, 274, 275, 279, 291, 299, 303, 306, ...	[ "B-signs", "I-signs", "I-signs", "I-signs", "I-signs", "O", "B-disease", "I-disease", "I-disease", "I-disease", "I-disease", "I-disease", "I-disease", "I-disease", "I-disease", "O", "B-signs", "I-signs", "I-signs", "O", "O", "O", "O", "B-disease", "I-disease", "O", ...	[ 15, 16, 16, 16, 16, 0, 3, 4, 4, 4, 4, 4, 4, 4, 4, 0, 15, 16, 16, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 13, 0, 0, 15, 16, 0, 0, 0, 0, 0, 0, 0, 13, 14, 0, 0, 0, 0, 0, 0, ...
MDIEC/10029644	Effects of family history and place and season of birth on the risk of schizophrenia. BACKGROUND Although a family history of schizophrenia is the best-established risk factor for schizophrenia, environmental factors such as the place and season of birth may also be important. METHODS Using data from the Civil Regist...	T0 disease 71 84 schizophrenia T1 Health_factors 11 25 family history T4 Health_factors 30 55 place and season of birth T6 disease 180 193 schizophrenia T8 Health_factors 195 216 environmental factors T11 Health_factors 229 254 place and season of birth T13 Health_factors 108 139 family history of schizophrenia T14 met...	[ "Effects", "of", "family", "history", "and", "place", "and", "season", "of", "birth", "on", "the", "risk", "of", "schizophrenia", ".", "BACKGROUND", "Although", "a", "family", "history", "of", "schizophrenia", "is", "the", "best", "-", "established", "risk", ...	[ 0, 8, 11, 18, 26, 30, 36, 40, 47, 50, 56, 59, 63, 68, 71, 84, 86, 97, 106, 108, 115, 123, 126, 140, 143, 147, 151, 152, 164, 169, 176, 180, 193, 195, 209, 217, 222, 225, 229, 235, 239, 246, 249, 255, 259, 264, 267, 276, ...	[ 7, 10, 17, 25, 29, 35, 39, 46, 49, 55, 58, 62, 67, 70, 84, 85, 96, 105, 107, 114, 122, 125, 139, 142, 146, 151, 152, 163, 168, 175, 179, 193, 194, 208, 216, 221, 224, 228, 234, 238, 245, 248, 254, 258, 263, 266, 276, 277, ...	[ "O", "O", "B-Health_factors", "I-Health_factors", "O", "B-Health_factors", "I-Health_factors", "I-Health_factors", "I-Health_factors", "I-Health_factors", "O", "O", "O", "O", "B-disease", "O", "O", "O", "O", "B-Health_factors", "I-Health_factors", "I-Health_factors", "I-H...	[ 0, 0, 1, 2, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 3, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 1, 2, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 9,...
MDIEC/32828165	Psychosis relapse during treatment with long-acting injectable antipsychotics in individuals with schizophrenia-spectrum disorders: an individual participant data meta-analysis. BACKGROUND Most individuals with schizophrenia-spectrum disorders have relapses, which increase the risk of morbidity and mortality. Because n...	T0 disease 0 17 Psychosis relapse T1 disease 98 130 schizophrenia-spectrum disorders T3 drug 40 77 long-acting injectable antipsychotics T5 method 135 176 individual participant data meta-analysis T7 disease 211 243 schizophrenia-spectrum disorders T8 Health_factors 249 257 relapses T9 disease 286 295 morbidity T10 dis...	[ "Psychosis", "relapse", "during", "treatment", "with", "long", "-", "acting", "injectable", "antipsychotics", "in", "individuals", "with", "schizophrenia", "-", "spectrum", "disorders", ":", "an", "individual", "participant", "data", "meta", "-", "analysis", ".", ...	[ 0, 10, 18, 25, 35, 40, 44, 45, 52, 63, 78, 81, 93, 98, 111, 112, 121, 130, 132, 135, 146, 158, 163, 167, 168, 176, 178, 189, 194, 206, 211, 224, 225, 234, 244, 249, 257, 259, 265, 274, 278, 283, 286, 296, 300, 309, 311, 31...	[ 9, 17, 24, 34, 39, 44, 45, 51, 62, 77, 80, 92, 97, 111, 112, 120, 130, 131, 134, 145, 157, 162, 167, 168, 176, 177, 188, 193, 205, 210, 224, 225, 233, 243, 248, 257, 258, 264, 273, 277, 282, 285, 295, 299, 309, 310, 318, 3...	[ "B-disease", "I-disease", "O", "O", "O", "B-drug", "I-drug", "I-drug", "I-drug", "I-drug", "O", "O", "O", "B-disease", "I-disease", "I-disease", "I-disease", "O", "O", "B-method", "I-method", "I-method", "I-method", "I-method", "I-method", "O", "O", "O", "O", ...	[ 3, 4, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 3, 4, 4, 4, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 3, 0, 3, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 3...
MDIEC/13678875	Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. BACKGROUND Results of array studies have suggested abnormalities in expression of lipid and myelin-related genes in schizophrenia. Here, we investigated oligodendrocyte-specific and myelination-associated gene expression in schizophrenia and bipolar aff...	T1 disease 0 27 Oligodendrocyte dysfunction T2 disease 31 44 schizophrenia T3 disease 49 65 bipolar disorder T4 disease 183 196 schizophrenia T8 gene 149 179 lipid and myelin-related genes T10 method 89 102 array studies T12 disease 291 304 schizophrenia T13 disease 309 335 bipolar affective disorder T15 physiology 220...	[ "Oligodendrocyte", "dysfunction", "in", "schizophrenia", "and", "bipolar", "disorder", ".", "BACKGROUND", "Results", "of", "array", "studies", "have", "suggested", "abnormalities", "in", "expression", "of", "lipid", "and", "myelin", "-", "related", "genes", "in", ...	[ 0, 16, 28, 31, 45, 49, 57, 65, 67, 78, 86, 89, 95, 103, 108, 118, 132, 135, 146, 149, 155, 159, 165, 166, 174, 180, 183, 196, 198, 202, 204, 207, 220, 235, 236, 245, 249, 260, 261, 272, 277, 288, 291, 305, 309, 317, 327, 3...	[ 15, 27, 30, 44, 48, 56, 65, 66, 77, 85, 88, 94, 102, 107, 117, 131, 134, 145, 148, 154, 158, 165, 166, 173, 179, 182, 196, 197, 202, 203, 206, 219, 235, 236, 244, 248, 260, 261, 271, 276, 287, 290, 304, 308, 316, 326, 335, ...	[ "B-disease", "I-disease", "O", "B-disease", "O", "B-disease", "I-disease", "O", "O", "O", "O", "B-method", "I-method", "O", "O", "O", "O", "O", "O", "B-gene", "I-gene", "I-gene", "I-gene", "I-gene", "I-gene", "O", "B-disease", "O", "O", "O", "O", "O", ...	[ 3, 4, 0, 3, 0, 3, 4, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 0, 3, 0, 0, 0, 0, 0, 11, 12, 12, 12, 12, 12, 12, 12, 12, 0, 3, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 0, 0, ...
MDIEC/33971098	Depression. Most psychiatric care is delivered in primary care settings, where depression is the most common presenting psychiatric symptom. Given the high prevalence of depression worldwide and the well-established consequences of untreated depression, the ability of primary care clinicians to effectively diagnose and...	T1 disease 0 10 Depression T2 disease 79 89 depression T3 disease 170 180 depression T4 disease 242 252 depression T5 disease 430 455 major depressive disorder T6 method 50 62 primary care T7 Health_factors 269 292 primary care clinicians T10 method 17 33 psychiatric care T9 disease 120 139 psychiatric symptom R1 hypon...	[ "Depression", ".", "Most", "psychiatric", "care", "is", "delivered", "in", "primary", "care", "settings", ",", "where", "depression", "is", "the", "most", "common", "presenting", "psychiatric", "symptom", ".", "Given", "the", "high", "prevalence", "of", "depress...	[ 0, 10, 12, 17, 29, 34, 37, 47, 50, 58, 63, 71, 73, 79, 90, 93, 97, 102, 109, 120, 132, 139, 141, 147, 151, 156, 167, 170, 181, 191, 195, 199, 203, 204, 216, 229, 232, 242, 252, 254, 258, 266, 269, 277, 282, 293, 296, 308, ...	[ 10, 11, 16, 28, 33, 36, 46, 49, 57, 62, 71, 72, 78, 89, 92, 96, 101, 108, 119, 131, 139, 140, 146, 150, 155, 166, 169, 180, 190, 194, 198, 203, 204, 215, 228, 231, 241, 252, 253, 257, 265, 268, 276, 281, 292, 295, 307, 316...	[ "B-disease", "O", "O", "B-method", "I-method", "O", "O", "O", "B-method", "I-method", "O", "O", "O", "B-disease", "O", "O", "O", "O", "O", "B-disease", "I-disease", "O", "O", "O", "O", "O", "O", "B-disease", "O", "O", "O", "O", "O", "O", "O", "O"...	[ 3, 0, 0, 9, 10, 0, 0, 0, 9, 10, 0, 0, 0, 3, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, ...
MDIEC/26873185	Childhood maltreatment and unfavourable clinical outcomes in bipolar disorder: a systematic review and meta-analysis. BACKGROUND Bipolar disorder affects up to one in 25 individuals and identification of early risk indicators of negative outcomes could facilitate early detection of patients with greatest clinical needs...	T0 disease 61 77 bipolar disorder T1 Health_factors 0 22 Childhood maltreatment T2 Health_factors 40 57 clinical outcomes T3 method 81 98 systematic review T4 method 103 116 meta-analysis T6 disease 129 145 Bipolar disorder T8 Health_factors 229 246 negative outcomes T9 disease 445 461 bipolar disorder T10 Health_facto...	[ "Childhood", "maltreatment", "and", "unfavourable", "clinical", "outcomes", "in", "bipolar", "disorder", ":", "a", "systematic", "review", "and", "meta", "-", "analysis", ".", "BACKGROUND", "Bipolar", "disorder", "affects", "up", "to", "one", "in", "25", "indivi...	[ 0, 10, 23, 27, 40, 49, 58, 61, 69, 77, 79, 81, 92, 99, 103, 107, 108, 116, 118, 129, 137, 146, 154, 157, 160, 164, 167, 170, 182, 186, 201, 204, 210, 215, 226, 229, 238, 247, 253, 264, 270, 280, 283, 292, 297, 306, 315, 32...	[ 9, 22, 26, 39, 48, 57, 60, 68, 77, 78, 80, 91, 98, 102, 107, 108, 116, 117, 128, 136, 145, 153, 156, 159, 163, 166, 169, 181, 185, 200, 203, 209, 214, 225, 228, 237, 246, 252, 263, 269, 279, 282, 291, 296, 305, 314, 320, 3...	[ "B-Health_factors", "I-Health_factors", "O", "O", "B-Health_factors", "I-Health_factors", "O", "B-disease", "I-disease", "O", "O", "B-method", "I-method", "O", "B-method", "I-method", "I-method", "O", "O", "B-disease", "I-disease", "O", "O", "O", "O", "O", "O", ...	[ 1, 2, 0, 0, 1, 2, 0, 3, 4, 0, 0, 9, 10, 0, 9, 10, 10, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, ...
MDIEC/20221122_9	Dual neurokinin(1) antagonists/5-HT reuptake inhibitors (SRIs) and melanocortin(4) antagonists/SRIs should display advantages over their selective counterparts, and histamine H(3) antagonists/SRIs, GABA(B) antagonists/SRIs, glutamatergic/SRIs, and cholinergic agents/SRIs may counter the compromised cognitive function o...	T1 drug 31 55 5-HT reuptake inhibitors T2 drug 198 222 GABA(B) antagonists/SRIs T6 disease 288 318 compromised cognitive function T7 drug 57 61 SRIs R1 abbreviation_for Arg1:T7 Arg2:T1 T8 drug 0 30 Dual neurokinin(1) antagonists T9 drug 67 99 melanocortin(4) antagonists/SRIs T11 drug 165 196 histamine H(3) antagonists...	[ "Dual", "neurokinin", "(", "1", ")", "antagonists", "/", "5", "-", "HT", "reuptake", "inhibitors", "(", "SRIs", ")", "and", "melanocortin", "(", "4", ")", "antagonists", "/", "SRIs", "should", "display", "advantages", "over", "their", "selective", "counterpa...	[ 0, 5, 15, 16, 17, 19, 30, 31, 32, 33, 36, 45, 56, 57, 61, 63, 67, 79, 80, 81, 83, 94, 95, 100, 107, 115, 126, 131, 137, 147, 159, 161, 165, 175, 176, 177, 178, 180, 191, 192, 196, 198, 202, 203, 204, 206, 217, 218, 222, ...	[ 4, 15, 16, 17, 18, 30, 31, 32, 33, 35, 44, 55, 57, 61, 62, 66, 79, 80, 81, 82, 94, 95, 99, 106, 114, 125, 130, 136, 146, 159, 160, 164, 174, 176, 177, 178, 179, 191, 192, 196, 197, 202, 203, 204, 205, 217, 218, 222, 223,...	[ "B-drug", "I-drug", "I-drug", "I-drug", "I-drug", "I-drug", "O", "B-drug", "I-drug", "I-drug", "I-drug", "I-drug", "O", "B-drug", "O", "O", "B-drug", "I-drug", "I-drug", "I-drug", "I-drug", "I-drug", "I-drug", "O", "O", "O", "O", "O", "O", "O", "O", "O",...	[ 5, 6, 6, 6, 6, 6, 0, 5, 6, 6, 6, 6, 0, 5, 0, 0, 5, 6, 6, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 6, 0, 5, 6, 6, 6, 6, 6, 6, 0, 5, 6, 6, 0, 0, 5, 6, 6, 6, 0, 0, 0, 3, 4, 4...
MDIEC/31371720	Obsessive-compulsive disorder. Obsessive-compulsive disorder (OCD) is a highly prevalent and chronic condition that is associated with substantial global disability. OCD is the key example of the 'obsessive-compulsive and related disorders', a group of conditions which are now classified together in the Diagnostic and ...	T0 disease 0 29 Obsessive-compulsive disorder T1 disease 31 60 Obsessive-compulsive disorder T2 disease 62 65 OCD T3 disease 154 164 disability T5 disease 93 110 chronic condition T6 disease 166 169 OCD T7 disease 197 239 obsessive-compulsive and related disorders T8 method 305 373 Diagnostic and Statistical Manual of ...	[ "Obsessive", "-", "compulsive", "disorder", ".", "Obsessive", "-", "compulsive", "disorder", "(", "OCD", ")", "is", "a", "highly", "prevalent", "and", "chronic", "condition", "that", "is", "associated", "with", "substantial", "global", "disability", ".", "OCD", ...	[ 0, 9, 10, 21, 29, 31, 40, 41, 52, 61, 62, 65, 67, 70, 72, 79, 89, 93, 101, 111, 116, 119, 130, 135, 147, 154, 164, 166, 170, 173, 177, 181, 189, 192, 196, 197, 206, 207, 218, 222, 230, 239, 240, 242, 244, 250, 253, 264, ...	[ 9, 10, 20, 29, 30, 40, 41, 51, 60, 62, 65, 66, 69, 71, 78, 88, 92, 100, 110, 115, 118, 129, 134, 146, 153, 164, 165, 169, 172, 176, 180, 188, 191, 195, 197, 206, 207, 217, 221, 229, 239, 240, 241, 243, 249, 252, 263, 269, ...	[ "B-disease", "I-disease", "I-disease", "I-disease", "O", "B-disease", "I-disease", "I-disease", "I-disease", "O", "B-disease", "O", "O", "O", "O", "O", "O", "B-disease", "I-disease", "O", "O", "O", "O", "O", "O", "B-disease", "O", "B-disease", "O", "O", "O...	[ 3, 4, 4, 4, 0, 3, 4, 4, 4, 0, 3, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 3, 0, 3, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, ...
MDIEC/20221103_130	Both unilateral and bilateral subthalamic (STN) deep brain stimulation (DBS) effectively treat the motor symptoms of PD, but questions remain regarding the impact of unilateral STN DBS on non-motor symptoms, such as depression.	T1 region 43 46 STN T3 method 48 70 deep brain stimulation T4 method 72 75 DBS T6 disease 99 113 motor symptoms T9 method 166 184 unilateral STN DBS T10 disease 188 206 non-motor symptoms T11 disease 216 226 depression R1 abbreviation_for Arg1:T4 Arg2:T3 T12 region 30 41 subthalamic R2 abbreviation_for Arg1:T1 Arg2:T1...	[ "Both", "unilateral", "and", "bilateral", "subthalamic", "(", "STN", ")", "deep", "brain", "stimulation", "(", "DBS", ")", "effectively", "treat", "the", "motor", "symptoms", "of", "PD", ",", "but", "questions", "remain", "regarding", "the", "impact", "of", ...	[ 0, 5, 16, 20, 30, 42, 43, 46, 48, 53, 59, 71, 72, 75, 77, 89, 95, 99, 105, 114, 117, 119, 121, 125, 135, 142, 152, 156, 163, 166, 177, 181, 185, 188, 191, 192, 198, 206, 208, 213, 216, 226 ]	[ 4, 15, 19, 29, 41, 43, 46, 47, 52, 58, 70, 72, 75, 76, 88, 94, 98, 104, 113, 116, 119, 120, 124, 134, 141, 151, 155, 162, 165, 176, 180, 184, 187, 191, 192, 197, 206, 207, 212, 215, 226, 227 ]	[ "O", "B-region", "I-region", "I-region", "I-region", "O", "B-region", "O", "B-method", "I-method", "I-method", "O", "B-method", "O", "O", "O", "O", "B-disease", "I-disease", "O", "B-disease", "O", "O", "O", "O", "O", "O", "O", "O", "B-method", "I-method", ...	[ 0, 13, 14, 14, 14, 0, 13, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 3, 4, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 0, 3, 4, 4, 4, 0, 0, 0, 3, 0 ]
MDIEC/20221103_63	This enhanced [(18)F]FLT-PET imaging technique with probenecid can be used to assess the dynamic alteration of neurogenic activity in the adult mammalian brain and may also provide a means for objective diagnosis of depression and monitoring of the therapeutic effect of antidepressant treatment.	T1 method 5 46 enhanced [(18)F]FLT-PET imaging technique T2 drug 52 62 probenecid T3 physiology 111 130 neurogenic activity T5 region 138 159 adult mammalian brain T7 disease 216 226 depression T10 method 271 295 antidepressant treatment R1 help_diagnose Arg1:T1 Arg2:T3 R2 located_in Arg1:T3 Arg2:T5 R3 help_diagnose ...	[ "This", "enhanced", "[", "(", "18", ")", "F", "]", "FLT", "-", "PET", "imaging", "technique", "with", "probenecid", "can", "be", "used", "to", "assess", "the", "dynamic", "alteration", "of", "neurogenic", "activity", "in", "the", "adult", "mammalian", "bra...	[ 0, 5, 14, 15, 16, 18, 19, 20, 21, 24, 25, 29, 37, 47, 52, 63, 67, 70, 75, 78, 85, 89, 97, 108, 111, 122, 131, 134, 138, 144, 154, 160, 164, 168, 173, 181, 183, 189, 193, 203, 213, 216, 227, 231, 242, 245, 249, 261, 268, ...	[ 4, 13, 15, 16, 18, 19, 20, 21, 24, 25, 28, 36, 46, 51, 62, 66, 69, 74, 77, 84, 88, 96, 107, 110, 121, 130, 133, 137, 143, 153, 159, 163, 167, 172, 180, 182, 188, 192, 202, 212, 215, 226, 230, 241, 244, 248, 260, 267, 270...	[ "O", "B-method", "I-method", "I-method", "I-method", "I-method", "I-method", "I-method", "I-method", "I-method", "I-method", "I-method", "I-method", "O", "B-drug", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-physiology", "I-physiology", "O", "O", "B-region...	[ 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 11, 12, 0, 0, 13, 14, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
MDIEC/20221122_17	We found significant correlations between PHQ-8 scores and angina frequency (SAQ-AF, r=-0.28), physical limitation (SAQ-PL, r=-0.32) and disease perception (SAQ-DS r=-0.37, all P<0.001), which remained significant after adjustment for clinical characteristics, CAD severity, and anti-depressant use.	T2 method 42 47 PHQ-8 T3 disease 59 65 angina T4 disease 137 155 disease perception T13 Health_factors 235 259 clinical characteristics T14 drug 279 294 anti-depressant R1 associated_with Arg1:T2 Arg2:T3 T1 disease 95 114 physical limitation T5 method 77 83 SAQ-AF T6 disease 261 264 CAD T7 method 116 122 SAQ-PL T8 met...	[ "We", "found", "significant", "correlations", "between", "PHQ", "-", "8", "scores", "and", "angina", "frequency", "(", "SAQ", "-", "AF", ",", "r", "=", "-", "0", ".", "28", ")", ",", "physical", "limitation", "(", "SAQ", "-", "PL", ",", "r", "=", "...	[ 0, 3, 9, 21, 34, 42, 45, 46, 48, 55, 59, 66, 76, 77, 80, 81, 83, 85, 86, 87, 88, 89, 90, 92, 93, 95, 104, 115, 116, 119, 120, 122, 124, 125, 126, 127, 128, 129, 131, 133, 137, 145, 156, 157, 160, 161, 164, 165, 166, 16...	[ 2, 8, 20, 33, 41, 45, 46, 47, 54, 58, 65, 75, 77, 80, 81, 83, 84, 86, 87, 88, 89, 90, 92, 93, 94, 103, 114, 116, 119, 120, 122, 123, 125, 126, 127, 128, 129, 131, 132, 136, 144, 155, 157, 160, 161, 163, 165, 166, 167, ...	[ "O", "O", "O", "O", "O", "B-method", "I-method", "I-method", "O", "O", "B-disease", "O", "O", "B-method", "I-method", "I-method", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-disease", "I-disease", "O", "B-method", "I-method", "I-method", "O", "O", ...	[ 0, 0, 0, 0, 0, 9, 10, 10, 0, 0, 3, 0, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, ...
MDIEC/20221103_155	OBJECTIVES: This study examined national trends in 12-month prevalence of major depressive episodes (MDEs) in adolescents and young adults overall and in different sociodemographic groups, as well as trends in depression treatment between 2005 and 2014.	T2 disease 74 99 major depressive episodes T3 Health_factors 110 121 adolescents T4 Health_factors 126 138 young adults T5 Health_factors 164 187 sociodemographic groups T6 disease 210 220 depression T1 disease 101 105 MDEs R1 abbreviation_for Arg1:T1 Arg2:T2 R2 occurs_in Arg1:T1 Arg2:T3 R3 occurs_in Arg1:T1 Arg2:T4 ...	[ "OBJECTIVES", ":", "This", "study", "examined", "national", "trends", "in", "12", "-", "month", "prevalence", "of", "major", "depressive", "episodes", "(", "MDEs", ")", "in", "adolescents", "and", "young", "adults", "overall", "and", "in", "different", "sociod...	[ 0, 10, 12, 17, 23, 32, 41, 48, 51, 53, 54, 60, 71, 74, 80, 91, 100, 101, 105, 107, 110, 122, 126, 132, 139, 147, 151, 154, 164, 181, 187, 189, 192, 197, 200, 207, 210, 221, 231, 239, 244, 248, 252 ]	[ 10, 11, 16, 22, 31, 40, 47, 50, 53, 54, 59, 70, 73, 79, 90, 99, 101, 105, 106, 109, 121, 125, 131, 138, 146, 150, 153, 163, 180, 187, 188, 191, 196, 199, 206, 209, 220, 230, 238, 243, 247, 252, 253 ]	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-disease", "I-disease", "I-disease", "O", "B-disease", "O", "O", "B-Health_factors", "O", "B-Health_factors", "I-Health_factors", "O", "O", "O", "O", "B-Health_factors", "I-Health_factors", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 3, 0, 0, 1, 0, 1, 2, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0 ]
MDIEC/32296353	Depression, Mindfulness, and Psilocybin: Possible Complementary Effects of Mindfulness Meditation and Psilocybin in the Treatment of Depression. A Review. Depression is a major public health problem that affects approximately 4.4% of the global population. Since conventional pharmacotherapies and psychotherapies are on...	T1 drug 29 39 Psilocybin T2 drug 102 112 Psilocybin T3 disease 133 143 Depression T4 disease 155 165 Depression T5 drug 483 493 psilocybin T6 disease 824 834 depression T7 drug 882 892 psilocybin T8 disease 1102 1127 major depression disorder T9 drug 1615 1625 psilocybin T10 method 1845 1847 MM T11 drug 2033 2043 psilo...	[ "Depression", ",", "Mindfulness", ",", "and", "Psilocybin", ":", "Possible", "Complementary", "Effects", "of", "Mindfulness", "Meditation", "and", "Psilocybin", "in", "the", "Treatment", "of", "Depression", ".", "A", "Review", ".", "Depression", "is", "a", "majo...	[ 0, 10, 12, 23, 25, 29, 39, 41, 50, 64, 72, 75, 87, 98, 102, 113, 116, 120, 130, 133, 143, 145, 147, 153, 155, 166, 169, 171, 177, 184, 191, 199, 204, 212, 226, 227, 228, 229, 231, 234, 238, 245, 255, 257, 263, 276, 294, 29...	[ 10, 11, 23, 24, 28, 39, 40, 49, 63, 71, 74, 86, 97, 101, 112, 115, 119, 129, 132, 143, 144, 146, 153, 154, 165, 168, 170, 176, 183, 190, 198, 203, 211, 225, 227, 228, 229, 230, 233, 237, 244, 255, 256, 262, 275, 293, 297, ...	[ "B-disease", "O", "B-method", "O", "O", "B-drug", "O", "O", "O", "O", "O", "B-method", "I-method", "O", "B-drug", "O", "O", "O", "O", "B-disease", "O", "O", "O", "O", "B-disease", "O", "O", "O", "B-Health_factors", "I-Health_factors", "I-Health_factors", ...	[ 3, 0, 9, 0, 0, 5, 0, 0, 0, 0, 0, 9, 10, 0, 5, 0, 0, 0, 0, 3, 0, 0, 0, 0, 3, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, ...
MDIEC/30192101	Psychological interventions to reduce positive symptoms in schizophrenia: systematic review and network meta-analysis. Psychological treatments are increasingly regarded as useful interventions for schizophrenia. However, a comprehensive evaluation of the available evidence is lacking and the benefit of psychological i...	T0 disease 59 72 schizophrenia T1 method 0 27 Psychological interventions T2 method 74 91 systematic review T3 method 96 117 network meta-analysis T4 disease 38 55 positive symptoms T5 disease 198 211 schizophrenia T6 method 119 143 Psychological treatments T7 method 180 193 interventions T9 method 305 332 psychologica...	[ "Psychological", "interventions", "to", "reduce", "positive", "symptoms", "in", "schizophrenia", ":", "systematic", "review", "and", "network", "meta", "-", "analysis", ".", "Psychological", "treatments", "are", "increasingly", "regarded", "as", "useful", "interventio...	[ 0, 14, 28, 31, 38, 47, 56, 59, 72, 74, 85, 92, 96, 104, 108, 109, 117, 119, 133, 144, 148, 161, 170, 173, 180, 194, 198, 211, 213, 220, 222, 224, 238, 249, 252, 256, 266, 275, 278, 286, 290, 294, 302, 305, 319, 333, 337, 3...	[ 13, 27, 30, 37, 46, 55, 58, 72, 73, 84, 91, 95, 103, 108, 109, 117, 118, 132, 143, 147, 160, 169, 172, 179, 193, 197, 211, 212, 220, 221, 223, 237, 248, 251, 255, 265, 274, 277, 285, 289, 293, 301, 304, 318, 332, 336, 345, ...	[ "B-method", "I-method", "O", "O", "B-disease", "I-disease", "O", "B-disease", "O", "B-method", "I-method", "O", "B-method", "I-method", "I-method", "I-method", "O", "B-method", "I-method", "O", "O", "O", "O", "O", "B-method", "O", "B-disease", "O", "O", "O",...	[ 9, 10, 0, 0, 3, 4, 0, 3, 0, 9, 10, 0, 9, 10, 10, 10, 0, 9, 10, 0, 0, 0, 0, 0, 9, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, ...
MDIEC/20221103_58	In recent years, deep brain stimulation (DBS) has evolved as a potential tool to modulate pathological neural activity; stimulation of the subgenual cingulate (Cg25) has been shown to reduce depressive symptoms, including anhedonia.	T1 method 17 39 deep brain stimulation T2 method 41 44 DBS T4 physiology 90 118 pathological neural activity T7 region 139 158 subgenual cingulate T8 disease 191 210 depressive symptoms T9 disease 222 231 anhedonia R1 abbreviation_for Arg1:T2 Arg2:T1 R2 associated_with Arg1:T2 Arg2:T4 R3 associated_with Arg1:T1 Arg2:...	[ "In", "recent", "years", ",", "deep", "brain", "stimulation", "(", "DBS", ")", "has", "evolved", "as", "a", "potential", "tool", "to", "modulate", "pathological", "neural", "activity", ";", "stimulation", "of", "the", "subgenual", "cingulate", "(", "Cg25", "...	[ 0, 3, 10, 15, 17, 22, 28, 40, 41, 44, 46, 50, 58, 61, 63, 73, 78, 81, 90, 103, 110, 118, 120, 132, 135, 139, 149, 159, 160, 164, 166, 170, 175, 181, 184, 191, 202, 210, 212, 222, 231 ]	[ 2, 9, 15, 16, 21, 27, 39, 41, 44, 45, 49, 57, 60, 62, 72, 77, 80, 89, 102, 109, 118, 119, 131, 134, 138, 148, 158, 160, 164, 165, 169, 174, 180, 183, 190, 201, 210, 211, 221, 231, 232 ]	[ "O", "O", "O", "O", "B-method", "I-method", "I-method", "O", "B-method", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-physiology", "I-physiology", "I-physiology", "O", "B-method", "I-method", "I-method", "I-method", "I-method", "O", "B-region", "O", "O"...	[ 0, 0, 0, 0, 9, 10, 10, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 11, 12, 12, 0, 9, 10, 10, 10, 10, 0, 13, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 3, 0 ]
MDIEC/31569326	Lifestyle interventions for mental health. BACKGROUND: Mental illness is the single most common reason for patient visits to a general practitioner (GP). Prevalent mental illnesses include major depression disorder and dysthymia, anxiety disorders, bipolar disorders and schizophrenia. Patients with severe mental illnes...	T2 disease 55 69 Mental illness T3 disease 164 180 mental illnesses T4 disease 189 214 major depression disorder T5 disease 219 228 dysthymia T6 disease 230 247 anxiety disorders T7 disease 249 266 bipolar disorders T8 disease 271 284 schizophrenia T9 disease 300 321 severe mental illness T10 disease 604 620 mental ill...	[ "Lifestyle", "interventions", "for", "mental", "health", ".", "BACKGROUND", ":", "Mental", "illness", "is", "the", "single", "most", "common", "reason", "for", "patient", "visits", "to", "a", "general", "practitioner", "(", "GP", ")", ".", "Prevalent", "mental...	[ 0, 10, 24, 28, 35, 41, 43, 53, 55, 62, 70, 73, 77, 84, 89, 96, 103, 107, 115, 122, 125, 127, 135, 148, 149, 151, 152, 154, 164, 171, 181, 189, 195, 206, 215, 219, 228, 230, 238, 247, 249, 257, 267, 271, 284, 286, 295, 300,...	[ 9, 23, 27, 34, 41, 42, 53, 54, 61, 69, 72, 76, 83, 88, 95, 102, 106, 114, 121, 124, 126, 134, 147, 149, 151, 152, 153, 163, 170, 180, 188, 194, 205, 214, 218, 228, 229, 237, 247, 248, 256, 266, 270, 284, 285, 294, 299, 306...	[ "B-method", "I-method", "O", "B-Health_factors", "I-Health_factors", "O", "O", "O", "B-disease", "I-disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Health_factors", "I-Health_factors", "O", "B-Health_factors", "O", "O", "O", "B-disease", ...	[ 9, 10, 0, 1, 2, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 0, 0, 0, 3, 4, 0, 3, 4, 4, 0, 3, 0, 3, 4, 0, 3, 4, 0, 3, 0, 0, 0, 3, 4, 4, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0, ...
MDIEC/20221103_50	Additionally, this individually targeted rTMS can be integrated with cognitive interventions designed to activate the neural circuitry associated with promotion vs. prevention, thus allowing the neuroplasticity induced by the rTMS to benefit the systems likely to be involved in remediating depression.	T1 method 41 45 rTMS T2 method 226 230 rTMS T3 method 69 92 cognitive interventions T4 region 118 134 neural circuitry T7 physiology 195 210 neuroplasticity T8 disease 291 301 depression R1 associated_with Arg1:T7 Arg2:T2 R2 associated_with Arg1:T3 Arg2:T4	[ "Additionally", ",", "this", "individually", "targeted", "rTMS", "can", "be", "integrated", "with", "cognitive", "interventions", "designed", "to", "activate", "the", "neural", "circuitry", "associated", "with", "promotion", "vs", ".", "prevention", ",", "thus", "...	[ 0, 12, 14, 19, 32, 41, 46, 50, 53, 64, 69, 79, 93, 102, 105, 114, 118, 125, 135, 146, 151, 161, 163, 165, 175, 177, 182, 191, 195, 211, 219, 222, 226, 231, 234, 242, 246, 254, 261, 264, 267, 276, 279, 291, 301 ]	[ 12, 13, 18, 31, 40, 45, 49, 52, 63, 68, 78, 92, 101, 104, 113, 117, 124, 134, 145, 150, 160, 163, 164, 175, 176, 181, 190, 194, 210, 218, 221, 225, 230, 233, 241, 245, 253, 260, 263, 266, 275, 278, 290, 301, 302 ]	[ "O", "O", "O", "O", "O", "B-method", "O", "O", "O", "O", "B-method", "I-method", "O", "O", "O", "O", "B-region", "I-region", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-physiology", "O", "O", "O", "B-method", "O", "O", "O", "O", "O",...	[ 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 11, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0 ]
MDIEC/20221122_120	Obesity, educational attainment, body image, binge eating, physical health, psychological characteristics and interpersonal effectiveness were consistently associated with the relationship between obesity and depression.	T1 disease 0 7 Obesity T3 Health_factors 9 31 educational attainment T4 Health_factors 33 43 body image T5 disease 45 57 binge eating T6 Health_factors 59 74 physical health T7 Health_factors 76 105 psychological characteristics T9 disease 197 204 obesity T10 disease 209 219 depression T11 Health_factors 110 137 interp...	[ "Obesity", ",", "educational", "attainment", ",", "body", "image", ",", "binge", "eating", ",", "physical", "health", ",", "psychological", "characteristics", "and", "interpersonal", "effectiveness", "were", "consistently", "associated", "with", "the", "relationship",...	[ 0, 7, 9, 21, 31, 33, 38, 43, 45, 51, 57, 59, 68, 74, 76, 90, 106, 110, 124, 138, 143, 156, 167, 172, 176, 189, 197, 205, 209, 219 ]	[ 7, 8, 20, 31, 32, 37, 43, 44, 50, 57, 58, 67, 74, 75, 89, 105, 109, 123, 137, 142, 155, 166, 171, 175, 188, 196, 204, 208, 219, 220 ]	[ "B-disease", "O", "B-Health_factors", "I-Health_factors", "O", "B-Health_factors", "I-Health_factors", "O", "B-disease", "I-disease", "O", "B-Health_factors", "I-Health_factors", "O", "B-Health_factors", "I-Health_factors", "O", "B-Health_factors", "I-Health_factors", "O", "O...	[ 3, 0, 1, 2, 0, 1, 2, 0, 3, 4, 0, 1, 2, 0, 1, 2, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 3, 0, 3, 0 ]

MDIEC/20221103_175

In primary care pediatric settings, the EPDS and its shorter subscales have potential for use as effective depression screening tools.

T1 method 3 34 primary care pediatric settings T2 method 40 44 EPDS T3 method 107 133 depression screening tools R1 hyponym_of Arg1:T2 Arg2:T3

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MDIEC/33743882

Register-based metrics of years lived with disability associated with mental and substance use disorders: a register-based cohort study in Denmark. BACKGROUND Mental disorders account for a substantial proportion of the years lived with disability (YLDs) globally. These estimates have generally been calculated top down...

T0 disease 70 104 mental and substance use disorders T1 Health_factors 26 53 years lived with disability T3 method 108 135 register-based cohort study T4 method 0 22 Register-based metrics T5 disease 159 175 Mental disorders T7 Health_factors 220 247 years lived with disability T8 disease 462 496 mental and substance u...

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MDIEC/15292631

QT interval and QT dispersion in eating disorders. BACKGROUND Eating disorders are thought to be risk factors for cardiac sudden death secondary to arrhythmia. Results in previous studies on QT interval and QT dispersion, markers of fatal arrhythmia, have been inconsistent. METHODS We prospectively examined 179 femal...

T0 disease 33 49 eating disorders T1 signs 0 11 QT interval T2 disease 62 78 Eating disorders T3 disease 114 134 cardiac sudden death T4 disease 148 158 arrhythmia T6 disease 233 249 fatal arrhythmia T8 signs 191 202 QT interval T11 Health_factors 368 371 old T12 method 403 418 DSM-IV criteria T14 Health_factors 466 47...

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MDIEC/20221103_11

RESULTS: Depressed subjects who were not treated with antidepressant medications had lower levels of VZV-CMI following administration of zoster vaccine than nondepressed controls or depressed subjects receiving antidepressants even when antidepressant medications failed to alter depressive symptom severity (P<.005).

T1 disease 9 18 Depressed T3 drug 54 80 antidepressant medications T4 drug 237 263 antidepressant medications T6 drug 137 151 zoster vaccine T9 disease 182 191 depressed T10 drug 211 226 antidepressants T11 disease 280 298 depressive symptom T5 physiology 101 108 VZV-CMI R1 characteristic_of Arg1:T5 Arg2:T1 R2 treatme...

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MDIEC/32348643

Association between Mental Disorders and Subsequent Medical Conditions. BACKGROUND Persons with mental disorders are at a higher risk than the general population for the subsequent development of certain medical conditions. METHODS We used a population-based cohort from Danish national registries that included data o...

T1 disease 20 36 Mental Disorders T2 disease 96 112 mental disorders T3 disease 505 521 mental disorders T4 disease 722 738 mental disorders T5 disease 822 838 mental disorders T6 disease 1007 1022 mental disorder T7 disease 1168 1183 mental disorder T8 disease 1270 1286 mental disorders T9 disease 1364 1379 mental dis...

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MDIEC/20221103_47

Imaging and postmortem brain studies in depressed human subjects, in combination with animal behavioral models of depression, have identified a number of different cellular events, intracellular signaling pathways, proteins, and target genes that are modulated by stress and are potentially vital mediators of antidepres...

T1 method 0 36 Imaging and postmortem brain studies T2 disease 40 49 depressed T3 method 86 110 animal behavioral models T4 disease 114 124 depression T6 physiology 181 213 intracellular signaling pathways T9 disease 264 270 stress T11 physiology 310 331 antidepressant action T5 disease 164 179 cellular events R1 assoc...

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MDIEC/20221103_181

RESULTS: RMT treatment was associated with significant clinical improvement in depression scores at 8th week (Hamilton depression rating scale scores (Mean +- SEM) from 21.5 +- 2.44 to 14.31 +- 2.25, p <= 0.05).

T1 method 9 22 RMT treatment T2 disease 79 89 depression T3 method 110 149 Hamilton depression rating scale scores R1 treatment_for Arg1:T1 Arg2:T2 T4 method 159 162 SEM R2 help_diagnose Arg1:T3 Arg2:T2

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MDIEC/20221103_129

Controversy: Repetitive transcranial magnetic stimulation or transcranial direct current stimulation shows efficacy in treating psychiatric diseases (depression, mania, schizophrenia, obsessive-complusive disorder, panic, posttraumatic stress disorder).

T1 method 13 57 Repetitive transcranial magnetic stimulation T2 disease 128 148 psychiatric diseases T3 disease 150 160 depression T4 disease 162 167 mania T5 disease 169 182 schizophrenia T6 disease 184 213 obsessive-complusive disorder T7 disease 215 220 panic T8 disease 222 251 posttraumatic stress disorder T9 metho...

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MDIEC/11187420

Psychopharmacologic treatment strategies for depression, bipolar disorder, and schizophrenia. Patients with serious psychiatric disorders are frequently treated by primary care physicians, who may have difficulty keeping up with recent advances in psychiatry. This paper presents an updated synopsis for three major psyc...

T0 disease 45 55 depression T1 disease 57 73 bipolar disorder T2 disease 79 92 schizophrenia T3 method 0 40 Psychopharmacologic treatment strategies T4 disease 108 137 serious psychiatric disorders T6 Health_factors 164 187 primary care physicians T7 method 248 258 psychiatry T9 disease 316 337 psychiatric illnesses T1...

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MDIEC/34416346

Sub-regional hippocampal volumes in first-episode drug-naive major depression disorder. Hippocampal volume reduction was reported to underlie depressive symptomatology, however, the evidence to date remains inconsistent. For the complex intrinsic organization of hippocampus, the hippocampal volumes can be further divid...

T1 disease 36 86 first-episode drug-naive major depression disorder T2 disease 142 167 depressive symptomatology T3 disease 469 494 major depressive disorder T4 disease 496 499 MDD T5 disease 542 570 first-episode drug-naive MDD T6 disease 1002 1005 MDD T7 disease 1088 1091 MDD T8 disease 1304 1307 MDD T9 disease 1401 ...

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MDIEC/10029644

Effects of family history and place and season of birth on the risk of schizophrenia. BACKGROUND Although a family history of schizophrenia is the best-established risk factor for schizophrenia, environmental factors such as the place and season of birth may also be important. METHODS Using data from the Civil Regist...

T0 disease 71 84 schizophrenia T1 Health_factors 11 25 family history T4 Health_factors 30 55 place and season of birth T6 disease 180 193 schizophrenia T8 Health_factors 195 216 environmental factors T11 Health_factors 229 254 place and season of birth T13 Health_factors 108 139 family history of schizophrenia T14 met...

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MDIEC/32828165

Psychosis relapse during treatment with long-acting injectable antipsychotics in individuals with schizophrenia-spectrum disorders: an individual participant data meta-analysis. BACKGROUND Most individuals with schizophrenia-spectrum disorders have relapses, which increase the risk of morbidity and mortality. Because n...

T0 disease 0 17 Psychosis relapse T1 disease 98 130 schizophrenia-spectrum disorders T3 drug 40 77 long-acting injectable antipsychotics T5 method 135 176 individual participant data meta-analysis T7 disease 211 243 schizophrenia-spectrum disorders T8 Health_factors 249 257 relapses T9 disease 286 295 morbidity T10 dis...

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MDIEC/13678875

Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. BACKGROUND Results of array studies have suggested abnormalities in expression of lipid and myelin-related genes in schizophrenia. Here, we investigated oligodendrocyte-specific and myelination-associated gene expression in schizophrenia and bipolar aff...

T1 disease 0 27 Oligodendrocyte dysfunction T2 disease 31 44 schizophrenia T3 disease 49 65 bipolar disorder T4 disease 183 196 schizophrenia T8 gene 149 179 lipid and myelin-related genes T10 method 89 102 array studies T12 disease 291 304 schizophrenia T13 disease 309 335 bipolar affective disorder T15 physiology 220...

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[ "B-disease", "I-disease", "O", "B-disease", "O", "B-disease", "I-disease", "O", "O", "O", "O", "B-method", "I-method", "O", "O", "O", "O", "O", "O", "B-gene", "I-gene", "I-gene", "I-gene", "I-gene", "I-gene", "O", "B-disease", "O", "O", "O", "O", "O", ...

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MDIEC/33971098

Depression. Most psychiatric care is delivered in primary care settings, where depression is the most common presenting psychiatric symptom. Given the high prevalence of depression worldwide and the well-established consequences of untreated depression, the ability of primary care clinicians to effectively diagnose and...

T1 disease 0 10 Depression T2 disease 79 89 depression T3 disease 170 180 depression T4 disease 242 252 depression T5 disease 430 455 major depressive disorder T6 method 50 62 primary care T7 Health_factors 269 292 primary care clinicians T10 method 17 33 psychiatric care T9 disease 120 139 psychiatric symptom R1 hypon...

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MDIEC/26873185

Childhood maltreatment and unfavourable clinical outcomes in bipolar disorder: a systematic review and meta-analysis. BACKGROUND Bipolar disorder affects up to one in 25 individuals and identification of early risk indicators of negative outcomes could facilitate early detection of patients with greatest clinical needs...

T0 disease 61 77 bipolar disorder T1 Health_factors 0 22 Childhood maltreatment T2 Health_factors 40 57 clinical outcomes T3 method 81 98 systematic review T4 method 103 116 meta-analysis T6 disease 129 145 Bipolar disorder T8 Health_factors 229 246 negative outcomes T9 disease 445 461 bipolar disorder T10 Health_facto...

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MDIEC/20221122_9

Dual neurokinin(1) antagonists/5-HT reuptake inhibitors (SRIs) and melanocortin(4) antagonists/SRIs should display advantages over their selective counterparts, and histamine H(3) antagonists/SRIs, GABA(B) antagonists/SRIs, glutamatergic/SRIs, and cholinergic agents/SRIs may counter the compromised cognitive function o...

T1 drug 31 55 5-HT reuptake inhibitors T2 drug 198 222 GABA(B) antagonists/SRIs T6 disease 288 318 compromised cognitive function T7 drug 57 61 SRIs R1 abbreviation_for Arg1:T7 Arg2:T1 T8 drug 0 30 Dual neurokinin(1) antagonists T9 drug 67 99 melanocortin(4) antagonists/SRIs T11 drug 165 196 histamine H(3) antagonists...

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MDIEC/31371720

Obsessive-compulsive disorder. Obsessive-compulsive disorder (OCD) is a highly prevalent and chronic condition that is associated with substantial global disability. OCD is the key example of the 'obsessive-compulsive and related disorders', a group of conditions which are now classified together in the Diagnostic and ...

T0 disease 0 29 Obsessive-compulsive disorder T1 disease 31 60 Obsessive-compulsive disorder T2 disease 62 65 OCD T3 disease 154 164 disability T5 disease 93 110 chronic condition T6 disease 166 169 OCD T7 disease 197 239 obsessive-compulsive and related disorders T8 method 305 373 Diagnostic and Statistical Manual of ...

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MDIEC/20221103_130

Both unilateral and bilateral subthalamic (STN) deep brain stimulation (DBS) effectively treat the motor symptoms of PD, but questions remain regarding the impact of unilateral STN DBS on non-motor symptoms, such as depression.

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MDIEC/20221103_63

This enhanced [(18)F]FLT-PET imaging technique with probenecid can be used to assess the dynamic alteration of neurogenic activity in the adult mammalian brain and may also provide a means for objective diagnosis of depression and monitoring of the therapeutic effect of antidepressant treatment.

T1 method 5 46 enhanced [(18)F]FLT-PET imaging technique T2 drug 52 62 probenecid T3 physiology 111 130 neurogenic activity T5 region 138 159 adult mammalian brain T7 disease 216 226 depression T10 method 271 295 antidepressant treatment R1 help_diagnose Arg1:T1 Arg2:T3 R2 located_in Arg1:T3 Arg2:T5 R3 help_diagnose ...

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MDIEC/20221122_17

We found significant correlations between PHQ-8 scores and angina frequency (SAQ-AF, r=-0.28), physical limitation (SAQ-PL, r=-0.32) and disease perception (SAQ-DS r=-0.37, all P<0.001), which remained significant after adjustment for clinical characteristics, CAD severity, and anti-depressant use.

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MDIEC/20221103_155

OBJECTIVES: This study examined national trends in 12-month prevalence of major depressive episodes (MDEs) in adolescents and young adults overall and in different sociodemographic groups, as well as trends in depression treatment between 2005 and 2014.

T2 disease 74 99 major depressive episodes T3 Health_factors 110 121 adolescents T4 Health_factors 126 138 young adults T5 Health_factors 164 187 sociodemographic groups T6 disease 210 220 depression T1 disease 101 105 MDEs R1 abbreviation_for Arg1:T1 Arg2:T2 R2 occurs_in Arg1:T1 Arg2:T3 R3 occurs_in Arg1:T1 Arg2:T4 ...

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MDIEC/32296353

Depression, Mindfulness, and Psilocybin: Possible Complementary Effects of Mindfulness Meditation and Psilocybin in the Treatment of Depression. A Review. Depression is a major public health problem that affects approximately 4.4% of the global population. Since conventional pharmacotherapies and psychotherapies are on...

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MDIEC/30192101

Psychological interventions to reduce positive symptoms in schizophrenia: systematic review and network meta-analysis. Psychological treatments are increasingly regarded as useful interventions for schizophrenia. However, a comprehensive evaluation of the available evidence is lacking and the benefit of psychological i...

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MDIEC/20221103_58

In recent years, deep brain stimulation (DBS) has evolved as a potential tool to modulate pathological neural activity; stimulation of the subgenual cingulate (Cg25) has been shown to reduce depressive symptoms, including anhedonia.

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MDIEC/31569326

Lifestyle interventions for mental health. BACKGROUND: Mental illness is the single most common reason for patient visits to a general practitioner (GP). Prevalent mental illnesses include major depression disorder and dysthymia, anxiety disorders, bipolar disorders and schizophrenia. Patients with severe mental illnes...

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MDIEC/20221103_50

Additionally, this individually targeted rTMS can be integrated with cognitive interventions designed to activate the neural circuitry associated with promotion vs. prevention, thus allowing the neuroplasticity induced by the rTMS to benefit the systems likely to be involved in remediating depression.

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MDIEC/20221122_120

Obesity, educational attainment, body image, binge eating, physical health, psychological characteristics and interpersonal effectiveness were consistently associated with the relationship between obesity and depression.

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