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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What growing dysjunction has been witnessed?
{ "answer_start": [ 292 ], "text": [ "a 'Valley of Death' 1,2 no less, between broadening strides in fundamental biomedical research and their incommensurate reach into the clinic. " ] }
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What is aiming to incorporate pathways to translation at the earliest stages?
{ "answer_start": [ 502 ], "text": [ " recent changes in the structure of government funding, 2 new public and private joint ventures and specialist undergraduate and postgraduate courses" ] }
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
How much have the number of biomedical research publications targeting 'translational' concepts has increased ?
{ "answer_start": [ 842 ], "text": [ "exponentially, up 1800%" ] }
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What ways to solve the issues are outlined?
{ "answer_start": [ 2042 ], "text": [ "by creatively leveraging the so-called 'strengths' of viruses. Viral RNA polymerisation and reverse transcription enable resistance to treatment by conferring extraordinary genetic diversity. " ] }
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
How do these exact processes ultimately restrict viral infectivity?
{ "answer_start": [ 2302 ], "text": [ " by strongly limiting virus genome sizes and their incorporation of new information. " ] }
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What does the author coin this evolutionary dilemma as?
{ "answer_start": [ 2424 ], "text": [ "'information economy paradox'." ] }
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
How do many viruses resolve this ?
{ "answer_start": [ 2492 ], "text": [ "by manipulating multifunctional or multitasking host cell proteins (MMHPs), thereby maximising host subversion and viral infectivity at minimal informational cost." ] }
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
How may this "Achilles Heel" be safely targeted?
{ "answer_start": [ 2725 ], "text": [ " via host-oriented therapies to impose devastating informational and fitness barriers on escape mutant selection." ] }
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
Why may MMHP-targeting therapies exhibit both robust and broadspectrum antiviral efficacy?
{ "answer_start": [ 2852 ], "text": [ "since MMHPs are often conserved targets within and between virus families," ] }
4131
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What will achieving this through drug repurposing do?
{ "answer_start": [ 3058 ], "text": [ " break the vicious cycle of escalating therapeutic development costs and trivial escape mutant selection, both quickly and in multiple places. " ] }
4132
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What are also discussed by the author?
{ "answer_start": [ 3215 ], "text": [ " alternative posttranslational and RNA-based antiviral approaches, designer vaccines, immunotherapy and the emerging field of neo-virology." ] }
4133
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What does the author anticipate international efforts will do?
{ "answer_start": [ 3429 ], "text": [ " will enable the tapping of useful new biological functions and processes, methods for controlling infection, and the deployment of symbiotic or subclinical viruses in new therapies and biotechnologies that are so crucially needed." ] }
4134
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What do pathogens do upon infection?
{ "answer_start": [ 3688 ], "text": [ "stimulate expression of numerous host inflammatory factors that support recruitment and activation of immune cells. " ] }
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What is the flip side ?
{ "answer_start": [ 3822 ], "text": [ "this same process also causes immunopathology when prolonged or deregulated." ] }
4139
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What do RBPs do?
{ "answer_start": [ 4022 ], "text": [ "post-transcriptionally control expression of crucial inflammatory factors in various tissues and their potential therapeutic applications" ] }
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What is included in RBPs?
{ "answer_start": [ 4182 ], "text": [ "tristetraprolin and AUF1" ] }
4141
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What do tristetraprolin and AUF1, do?
{ "answer_start": [ 4214 ], "text": [ "promote degradation of AU-rich element (ARE)-containing mRNA" ] }
4142
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What do RBPs include?
{ "answer_start": [ 4276 ], "text": [ "members of the Roquin and Regnase families" ] }
4143
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What domembers of the Roquin and Regnase families do?
{ "answer_start": [ 4339 ], "text": [ "promote or effect degradation of mRNAs harbouring stem-loop structures" ] }
4144
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What do the RBPs include?
{ "answer_start": [ 4453 ], "text": [ "RNA methylation machinery" ] }
4145
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What is the increasingly apparent role of RNA methylation machinery ?
{ "answer_start": [ 4479 ], "text": [ "in controlling inflammatory mRNA stability." ] }
4146
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
Where do these activities take place?
{ "answer_start": [ 4550 ], "text": [ " in various subcellular compartments " ] }
4147
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What happens to these activities during infection?
{ "answer_start": [ 4591 ], "text": [ "are differentially regulated" ] }
4148
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
In this way, what do the mRNA-destabilising RBPs constitute ?
{ "answer_start": [ 4686 ], "text": [ "a 'brake' on the immune system" ] }
4149
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What can be done with the 'brake' on the immune system?
{ "answer_start": [ 4724 ], "text": [ "may ultimately be toggled therapeutically" ] }
4150
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What does the author anticipate that continued efforts will lead to?
{ "answer_start": [ 5011 ], "text": [ "Another mRNA under post-transcriptional regulation by Regnase-1 and Roquin" ] }
4151
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What is another mRNA under post-transcriptional regulation by Regnase-1 and Roquin?
{ "answer_start": [ 5088 ], "text": [ " Furin" ] }
4152
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What does Furin encode?
{ "answer_start": [ 5110 ], "text": [ "a conserved proprotein convertase crucial in human health and disease." ] }
4153
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What are Furin, along with other PCSK family members implicated in?
{ "answer_start": [ 5246 ], "text": [ " in immune regulation, cancer and the entry, maturation or release of a broad array of evolutionarily diverse viruses including human papillomavirus (HPV), influenza (IAV), Ebola (EboV), dengue (DenV) and human immunodeficiency virus (HIV)" ] }
4154
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What do Braun and Sauter review?
{ "answer_start": [ 5516 ], "text": [ " the roles of furin in these processes, as well as the history and future of furin-targeting therapeutics." ] }
4155
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What dis their recent work reveal?
{ "answer_start": [ 5671 ], "text": [ "how two IFN-cinducible factors exhibit broad-spectrum inhibition of IAV, measles (MV), zika (ZikV) and HIV by suppressing furin activity." ] }
4156
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What has the increasing abundance of affordable, sensitive, high-throughput genome sequencing technologies led to?
{ "answer_start": [ 6119 ], "text": [ " a recent boom in metagenomics and the cataloguing of the microbiome of our world." ] }
4157
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What was this system used for the first time for?
{ "answer_start": [ 6678 ], "text": [ " to directly sequence an RNA virus genome (IAV)" ] }
4160
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What have decades of basic immunology research provided ?
{ "answer_start": [ 7152 ], "text": [ "a near-complete picture of the main armaments in the human antiviral arsenal. " ] }
4161
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What has this focus on mammalian defences and pathologies sidelined?
{ "answer_start": [ 7307 ], "text": [ "examination of the types and roles of viruses and antiviral defences that exist throughout our biosphere." ] }
4162
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What has CRISPR/Cas antiviral immune system of prokaryotes been repurposed as?
{ "answer_start": [ 7513 ], "text": [ "as a revolutionary gene-editing biotechnology in plants and animals." ] }
4163
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What is another case in point?
{ "answer_start": [ 7596 ], "text": [ "the ancient lineage of nucleocytosolic large DNA viruses (NCLDVs)" ] }
4164
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What are the ancient lineage of NCLDVs?
{ "answer_start": [ 7673 ], "text": [ "emerging human pathogens that possess enormous genomes of up to several megabases in size encoding hundreds of proteins with unique and unknown functions." ] }
4165
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What do the recent efforts indicate regarding hundreds of human and avian infectious viruses?
{ "answer_start": [ 7949 ], "text": [ " the true number may be in the millions and many harbour zoonotic potential. " ] }
4166
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What is neo-virology?
{ "answer_start": [ 8235 ], "text": [ " an emerging field engaged in cataloguing and characterising this biodiversity through a global consortium." ] }
4167
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What is predicted these efforts on neo-virology will unlock?
{ "answer_start": [ 8382 ], "text": [ "a vast wealth of currently unexplored biodiversity, leading to biotechnologies and treatments that leverage the host-virus interactions developed throughout evolution." ] }
4168
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What are the two of the four pillars of the National Innovation and Science Agenda?
{ "answer_start": [ 8965 ], "text": [ "Supporting industry-academia collaboration and nurturing talent and skills in the Indo-Pacific region" ] }
4169
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What do Australia's Medical Research and Innovation Priorities include?
{ "answer_start": [ 9226 ], "text": [ "antimicrobial resistance, global health and health security, drug repurposing and translational research infrastructure," ] }
4170
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What is essential for these priority outcomes?
{ "answer_start": [ 9414 ], "text": [ "Establishing durable international relationships that integrate diverse expertise" ] }
4171
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Frontiers in antiviral therapy and immunotherapy https://doi.org/10.1002/cti2.1115 SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf Authors: Heaton, Steven M Date: 2020 DOI: 10.1002/cti2.1115 License: cc-by Abstract: nan Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l...
2,669
What is the Japan AMED tasked with?
{ "answer_start": [ 9774 ], "text": [ "translating the biomedical research output of that country." ] }
4172
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Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566411/ SHA: ee48061797d29eeef5a9e606841bf8ab04b1d75b Authors: Beier, Kevin T.; Saunders, Arpiar B.; Oldenburg, Ian A.; Sabatini, Bernardo L.; C...
1,621
What virus are used by the most successful neuronal circuit tracing methods?
{ "answer_start": [ 2185 ], "text": [ "Pseudorabies (PRV) and Rabies viruses (RABV)" ] }
1935
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Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566411/ SHA: ee48061797d29eeef5a9e606841bf8ab04b1d75b Authors: Beier, Kevin T.; Saunders, Arpiar B.; Oldenburg, Ian A.; Sabatini, Bernardo L.; C...
1,621
In what direction does the Vesicular stomatitis virus spread through the nervous system?
{ "answer_start": [ 3221 ], "text": [ "anterograde" ] }
1936
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Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566411/ SHA: ee48061797d29eeef5a9e606841bf8ab04b1d75b Authors: Beier, Kevin T.; Saunders, Arpiar B.; Oldenburg, Ian A.; Sabatini, Bernardo L.; C...
1,621
What determines the whether the spread of Vesicular stomatitis virus is monosynaptic or polysynaptic?
{ "answer_start": [ 3603 ], "text": [ "method of delivery of the G gene" ] }
1937
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Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566411/ SHA: ee48061797d29eeef5a9e606841bf8ab04b1d75b Authors: Beier, Kevin T.; Saunders, Arpiar B.; Oldenburg, Ian A.; Sabatini, Bernardo L.; C...
1,621
What types of viruses can be used to study the connectivity of neuronal circuitry?
{ "answer_start": [ 31209 ], "text": [ "rVSV vectors" ] }
1938
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Identification of COVID-19 Can be Quicker through Artificial Intelligence framework using a Mobile Phone-Based Survey in the Populations when Cities/Towns Are Under Quarantine https://doi.org/10.1017/ice.2020.61 SHA: 83c96f2a481be06a5c58552cbad2ca67ce789dc2 Authors: Vazquez, Arni S.R. Srinivasa Rao; Jose A. Date: 20...
2,522
When was the novel Coronavirus first reported?
{ "answer_start": [ 974 ], "text": [ "December 2019" ] }
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Which Kind of Provider’s Operation Volumes Matters? Associations between CABG Surgical Site Infection Risk and Hospital and Surgeon Operation Volumes among Medical Centers in Taiwan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459823/ SHA: f3cbc0503581249a834895fc94cd3bae24714a0d Authors: Yu, Tsung-Hsien; Tung, Yu-...
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What is the purpose of this research study?
{ "answer_start": [ 793 ], "text": [ "to examine whether a relationship exists between operation volumes and SSIs" ] }
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Which Kind of Provider’s Operation Volumes Matters? Associations between CABG Surgical Site Infection Risk and Hospital and Surgeon Operation Volumes among Medical Centers in Taiwan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459823/ SHA: f3cbc0503581249a834895fc94cd3bae24714a0d Authors: Yu, Tsung-Hsien; Tung, Yu-...
1,598
Why are SSIs important to the overall burden on the healthcare system?
{ "answer_start": [ 2903 ], "text": [ "The total length of stay and expenditure for patients with SSIs after CABG surgery is significantly longer and higher than those without SSIs" ] }
5248
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Which Kind of Provider’s Operation Volumes Matters? Associations between CABG Surgical Site Infection Risk and Hospital and Surgeon Operation Volumes among Medical Centers in Taiwan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459823/ SHA: f3cbc0503581249a834895fc94cd3bae24714a0d Authors: Yu, Tsung-Hsien; Tung, Yu-...
1,598
What is the "Never Event" policy?
{ "answer_start": [ 3176 ], "text": [ "hospitals would no longer receive higher payments for the additional costs associated with treating patients for certain healthcare-acquired infections" ] }
5249
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Which Kind of Provider’s Operation Volumes Matters? Associations between CABG Surgical Site Infection Risk and Hospital and Surgeon Operation Volumes among Medical Centers in Taiwan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459823/ SHA: f3cbc0503581249a834895fc94cd3bae24714a0d Authors: Yu, Tsung-Hsien; Tung, Yu-...
1,598
Patients from how many medical centers were studied?
{ "answer_start": [ 9132 ], "text": [ "19" ] }
5250
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Which Kind of Provider’s Operation Volumes Matters? Associations between CABG Surgical Site Infection Risk and Hospital and Surgeon Operation Volumes among Medical Centers in Taiwan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459823/ SHA: f3cbc0503581249a834895fc94cd3bae24714a0d Authors: Yu, Tsung-Hsien; Tung, Yu-...
1,598
Which patients were excluded from the study?
{ "answer_start": [ 9250 ], "text": [ "CABG patients under the age of 18 years or over 85 years" ] }
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It is Unlikely That Influenza Viruses Will Cause a Pandemic Again Like What Happened in 1918 and 1919 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019839/ Song, Liting 2014-05-07 DOI:10.3389/fpubh.2014.00039 License:cc-by Abstract: nan Text: Influenza and influenza viruses are wellknown popular topics to medical p...
776
Approximately how many people died during the 1918-1919 influenza pandemic?
{ "answer_start": [ 1998 ], "text": [ "During the 1918-1919 influenza pandemic, between 21 and 25 million people died of influenza worldwide." ] }
259
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It is Unlikely That Influenza Viruses Will Cause a Pandemic Again Like What Happened in 1918 and 1919 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019839/ Song, Liting 2014-05-07 DOI:10.3389/fpubh.2014.00039 License:cc-by Abstract: nan Text: Influenza and influenza viruses are wellknown popular topics to medical p...
776
What social and economic factors contributed to the large fatality rate in the 1918 influenza pandemic?
{ "answer_start": [ 1637 ], "text": [ "Malnutrition weakened the human immune system and made a person more vulnerable to infectious diseases like tuberculosis and influenza, therefore, hunger and malnutrition were indirectly responsible for millions of deaths in the world in that period of time." ] }
286
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It is Unlikely That Influenza Viruses Will Cause a Pandemic Again Like What Happened in 1918 and 1919 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019839/ Song, Liting 2014-05-07 DOI:10.3389/fpubh.2014.00039 License:cc-by Abstract: nan Text: Influenza and influenza viruses are wellknown popular topics to medical p...
776
What problems were faced by medical staff during the 1918 epidemic?
{ "answer_start": [ 3392 ], "text": [ " in 1918 and 1919, physicians and nurses almost had nothing in their hands to help individuals who were infected by influenza viruses. T" ] }
291
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It is Unlikely That Influenza Viruses Will Cause a Pandemic Again Like What Happened in 1918 and 1919 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019839/ Song, Liting 2014-05-07 DOI:10.3389/fpubh.2014.00039 License:cc-by Abstract: nan Text: Influenza and influenza viruses are wellknown popular topics to medical p...
776
What helpful drugs are available now to control the disease or to provide palliative care for influenza patients?
{ "answer_start": [ 3526 ], "text": [ " Today, although we still do not have very effective, powerful, and practical anti-influenza drugs available, we at least have some improved, useful, and helpful anti-viral drugs like zanamivir, and effective, convenient anti-cold medicines like Tylenol or Advil." ...
295
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It is Unlikely That Influenza Viruses Will Cause a Pandemic Again Like What Happened in 1918 and 1919 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019839/ Song, Liting 2014-05-07 DOI:10.3389/fpubh.2014.00039 License:cc-by Abstract: nan Text: Influenza and influenza viruses are wellknown popular topics to medical p...
776
How has the mortality rate due to influenza declined in USA over past decades?
{ "answer_start": [ 3966 ], "text": [ " in the United States of America, the influenza classed mortality rate declined from 10.2/100,000 in the 1940s to 0.56/100,000 in the 1990s; and the classed mortality rates of 1957-1958 and 1968-1969 influenza pandemics were not remarkably different from the non-pand...
297
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It is Unlikely That Influenza Viruses Will Cause a Pandemic Again Like What Happened in 1918 and 1919 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019839/ Song, Liting 2014-05-07 DOI:10.3389/fpubh.2014.00039 License:cc-by Abstract: nan Text: Influenza and influenza viruses are wellknown popular topics to medical p...
776
Is there an Influenza vaccine?
{ "answer_start": [ 3790 ], "text": [ "We do not have a universal vaccine to prevent all influenza virus infections, but we can make effective vaccines to a specific influenza virus strain in a short time." ] }
299
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It is Unlikely That Influenza Viruses Will Cause a Pandemic Again Like What Happened in 1918 and 1919 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019839/ Song, Liting 2014-05-07 DOI:10.3389/fpubh.2014.00039 License:cc-by Abstract: nan Text: Influenza and influenza viruses are wellknown popular topics to medical p...
776
for the 2009 influenza pandemic, what were the case fatality rates?
{ "answer_start": [ 5087 ], "text": [ "that most cases of H1N1 influenza A virus infections were mild, the symptomatic case fatality rate was only 0.005% in New Zealand (16) ; and in New York City, the case fatality rate was 0.0094-0.0147% for persons ≥65 years old, and for those of 0-17 years old, the ca...
300
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It is Unlikely That Influenza Viruses Will Cause a Pandemic Again Like What Happened in 1918 and 1919 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019839/ Song, Liting 2014-05-07 DOI:10.3389/fpubh.2014.00039 License:cc-by Abstract: nan Text: Influenza and influenza viruses are wellknown popular topics to medical p...
776
What factors would contribute now to the faster rates of influenza infections?
{ "answer_start": [ 9615 ], "text": [ "Nowadays, we travel faster, and we travel more frequently and globally, and we have more complicated social activities and lifestyles, thereby increasing the chances of viral mutation; and we realize that influenza viruses are even easier to reassort, recombine, and ...
301
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It is Unlikely That Influenza Viruses Will Cause a Pandemic Again Like What Happened in 1918 and 1919 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019839/ Song, Liting 2014-05-07 DOI:10.3389/fpubh.2014.00039 License:cc-by Abstract: nan Text: Influenza and influenza viruses are wellknown popular topics to medical p...
776
What factors would be responsible in future for the prevention of an Influenza pandemic?
{ "answer_start": [ 10047 ], "text": [ " influenza virus infections are controllable and preventable, with the increased population health and immunity, with the WHO Global Influenza Surveillance and Response System, and with standard/routine epidemiological practices, and with new effective anti-viral ag...
302
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It is Unlikely That Influenza Viruses Will Cause a Pandemic Again Like What Happened in 1918 and 1919 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019839/ Song, Liting 2014-05-07 DOI:10.3389/fpubh.2014.00039 License:cc-by Abstract: nan Text: Influenza and influenza viruses are wellknown popular topics to medical p...
776
What was the detected fatality rate of H7N9 Avian flu?
{ "answer_start": [ 9523 ], "text": [ " the detected 32.14% (45/140, one case from Taiwan, and one case from Hong Kong) (22, 23).\n" ] }
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It is Unlikely That Influenza Viruses Will Cause a Pandemic Again Like What Happened in 1918 and 1919 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019839/ Song, Liting 2014-05-07 DOI:10.3389/fpubh.2014.00039 License:cc-by Abstract: nan Text: Influenza and influenza viruses are wellknown popular topics to medical p...
776
Why would real case fatality rate for the H7N9 be lower than detected rate?
{ "answer_start": [ 9149 ], "text": [ "most people usually think a common cold is a very common and normal occurrence, and they don't take flu-like illnesses seriously. In most situations, they would just stay home and take some medicines. Only those who have very severe flu-like symptoms would see doctor...
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Identifying Locations with Possible Undetected Imported Severe Acute Respiratory Syndrome Coronavirus 2 Cases by Using Importation Predictions, https://wwwnc.cdc.gov/eid/article/26/7/20-0250_article Volume 26, Number 7—July 2020 Research Pablo Martinez De Salazar1Comments to Author , René Niehus, Aimee Taylor1, Caroli...
186
What is the acronym SARS-CoV-2?
{ "answer_start": [ 524 ], "text": [ "severe acute respiratory syndrome coronavirus 2 " ] }
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Identifying Locations with Possible Undetected Imported Severe Acute Respiratory Syndrome Coronavirus 2 Cases by Using Importation Predictions, https://wwwnc.cdc.gov/eid/article/26/7/20-0250_article Volume 26, Number 7—July 2020 Research Pablo Martinez De Salazar1Comments to Author , René Niehus, Aimee Taylor1, Caroli...
186
When was SARS-CoV-2 first identified?
{ "answer_start": [ 1428 ], "text": [ "December 2019" ] }
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Identifying Locations with Possible Undetected Imported Severe Acute Respiratory Syndrome Coronavirus 2 Cases by Using Importation Predictions, https://wwwnc.cdc.gov/eid/article/26/7/20-0250_article Volume 26, Number 7—July 2020 Research Pablo Martinez De Salazar1Comments to Author , René Niehus, Aimee Taylor1, Caroli...
186
Where was SARS-CoV-2 first identified?
{ "answer_start": [ 1457 ], "text": [ "Wuhan, capital of Hubei Province, China" ] }
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Identifying Locations with Possible Undetected Imported Severe Acute Respiratory Syndrome Coronavirus 2 Cases by Using Importation Predictions, https://wwwnc.cdc.gov/eid/article/26/7/20-0250_article Volume 26, Number 7—July 2020 Research Pablo Martinez De Salazar1Comments to Author , René Niehus, Aimee Taylor1, Caroli...
186
What factor positively correlates with imported-and-reported cases counts of SARS-CoV-2 infection?
{ "answer_start": [ 11044 ], "text": [ "daily air travel volume" ] }
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Identifying Locations with Possible Undetected Imported Severe Acute Respiratory Syndrome Coronavirus 2 Cases by Using Importation Predictions, https://wwwnc.cdc.gov/eid/article/26/7/20-0250_article Volume 26, Number 7—July 2020 Research Pablo Martinez De Salazar1Comments to Author , René Niehus, Aimee Taylor1, Caroli...
186
What is the doubling time of the COVID-19 pandemic?
{ "answer_start": [ 1747 ], "text": [ "≈6 days" ] }
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
How was ILI defined?
{ "answer_start": [ 4410 ], "text": [ "as a sudden onset of fever more than 38 degrees Celsius and cough, associated or not with other symptoms such as breathing difficulty, headache, etc. " ] }
4101
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What is this assay based on?
{ "answer_start": [ 5499 ], "text": [ "on the multiplex ligation-dependent probe amplification (MLPA) technology." ] }
4104
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1,623
How was random sampling performed?
{ "answer_start": [ 5057 ], "text": [ " with Excel 1 using the anonymized surveillance database of the Cire OI. The sampling frame contained identification number of swab assigned by Cire OI, laboratory identification number, sex, age, date of onset of symptoms, date of swab collection and result of influ...
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1,623
What used to detect pathogens?
{ "answer_start": [ 5345 ], "text": [ " Respifinder 1 Smart 22 kits a multiplex RT-PCR (PathoFinder, Maastricht, The Netherlands) which can detect 22 respiratory pathogens. " ] }
4103
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What does the retrospective study use?
{ "answer_start": [ 666 ], "text": [ "nasal swabs collected by sentinel GPs from ILI patients in 2011 and 2012." ] }
4033
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1,623
How many swabs were randomly selected and analyzed?
{ "answer_start": [ 751 ], "text": [ "250 " ] }
4034
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
How were the swabs analyzed?
{ "answer_start": [ 796 ], "text": [ " by multiplex reverse transcriptase polymerase chain reaction (RT-PCR) including research of 18 viruses and 4 bacteria." ] }
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1,623
What viruses were detected?
{ "answer_start": [ 928 ], "text": [ "respiratory viruses in 169/222 (76.1%) samples, mostly rhinovirus (23.4%), influenza A virus (21.2%), influenza B virus (12.6%), coronavirus (4.9%) and Human metapneumovirus (3.6%). " ] }
4037
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1,623
What co-infections were found?
{ "answer_start": [ 1110 ], "text": [ "Nine swabs (5.3% of positive swabs) revealed co-infections with two viruses identified, among which six concerned co-infections with influenza viruses." ] }
4038
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What seasonal differences were found?
{ "answer_start": [ 1284 ], "text": [ "seasonal differences, with circulation of Human Metapneumoviruses, RSV A and B and coronavirus only during summer; whereas parainfluenza viruses were identified only during winter." ] }
4039
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What does the study highlight?
{ "answer_start": [ 1501 ], "text": [ " a substantial circulation of multiple respiratory pathogens in Réunion Island throughout the year. I" ] }
4040
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What does the study show?
{ "answer_start": [ 1610 ], "text": [ "that ILI are not only attributable to influenza and underlines the need for biological surveillance. As the use of multiplex RT-PCR showed its efficacy, it is now used routinely in the surveillance of ILI." ] }
4041
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
Which are identified as major viruses mostly responsible for ILI and pneumonia in several studies?
{ "answer_start": [ 1966 ], "text": [ "Influenza viruses, Respiratory Syncytial viruses (RSV) and Parainfluenza viruses" ] }
4042
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What percentage of these infections are identified?
{ "answer_start": [ 2294 ], "text": [ "less than 50%" ] }
4087
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What is Reunion Island?
{ "answer_start": [ 2330 ], "text": [ " a French overseas territory" ] }
4088
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What is the number of inhabitants of Reunion Island?
{ "answer_start": [ 2363 ], "text": [ " 850,000" ] }
4089
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
Where is Reunion Island located?
{ "answer_start": [ 2397 ], "text": [ "n the southern hemisphere between Madagascar and Mauritius in the Indian Ocean (Latitude: 21°05.2920 S Longitude: 55°36.4380 E.)" ] }
4090
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What is the island's health care system similar to?
{ "answer_start": [ 2579 ], "text": [ " to mainland France and epidemiological surveillance has been developed by the regional office of the French Institute for Public Health Surveillance (Cire OI), based on the surveillance system of mainland France" ] }
4091
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
When does influenza activity increase?
{ "answer_start": [ 2836 ], "text": [ " during austral winter, corresponding to summer in Europe" ] }
4092
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
When does the influenza vaccination campaign in Reunion Island start?
{ "answer_start": [ 2971 ], "text": [ "April " ] }
4093
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What is the clinical and biological influenza surveillance has been based on?
{ "answer_start": [ 3162 ], "text": [ "a sentinel practitioner's network" ] }
4094
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What is this network composed of?
{ "answer_start": [ 3240 ], "text": [ "58 general practitioners (GPs) spread over the island and represented around 7% of all Réunion Island GPs." ] }
4095
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
How are the influenza tests carried out?
{ "answer_start": [ 3346 ], "text": [ " Nasal swabs are randomly collected all along the year and are tested by RT-PCR for influenza viruses" ] }
4096
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What do 40-50% of the samples test positive for?
{ "answer_start": [ 3512 ], "text": [ " for influenza A virus, A(H1N1)pdm09 or B virus" ] }
4097
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What are the ILI samples wich test negative for influence?
{ "answer_start": [ 3683 ], "text": [ "are of unknown etiology" ] }
4098
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What tool has been developed to identify several viruses simultaneously?
{ "answer_start": [ 3806 ], "text": [ ", multiplex reverse transcriptase polymerase chain reaction (RT-PCR) " ] }
4099
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Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
What are the objectives of the study?
{ "answer_start": [ 4116 ], "text": [ "to characterize respiratory pathogens responsible for ILI consultations in sentinel GPs in 2011 and 2012. Secondary objectives were to highlight seasonal trends on respiratory pathogens circulation and to describe occurrence of co-infections, especially during the fl...
4100
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4,153
Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
On which system the reverse transcription and preamplification steps were performed?
{ "answer_start": [ 5642 ], "text": [ "on the epgradient Mastercycler 1 (Eppendorf) and the hybridization, ligation and detection steps on the LightCycler 1 480 system (Roche Applied Science)." ] }
4105
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5,664
Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in Réunion Island, 2011-2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031398/ SHA: f5ff89ebfdd0375d034c112c6c1c7e163fa69a0c Authors: Brottet, Elise; Jaffar-Bandjee, Marie-Christine; Li-Pat-Yuen, Ghislaine; Filleul, Laurent Date: 2016-09-21...
1,623
Which two seasons were identified for trends in virus circulation??
{ "answer_start": [ 6299 ], "text": [ "winter season during weeks 23 to 39 between June and September and summer season during the rest of the year." ] }
4106
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