update_datasets_splits
#2
by
yanwu2014
- opened
- .gitattributes +3 -62
- README.md +3 -22
- croissant.json +0 -219
- norman19_cpa_hvg_normalized_curated.h5ad.gz → norman19_cpa_hvg_normalized_curated.h5ad +2 -2
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norman19_cpa_hvg_normalized_curated.h5ad.gz filter=lfs diff=lfs merge=lfs -text
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README.md
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The dataset contains data used in work:
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"Perturbench: Benchmarking machine learning models for cellular perturbation analysis."
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The data comes from the following publications:
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- Norman, T. M., Horlbeck, M. A., Replogle, J. M., Ge, A. Y., Xu, A., Jost, M., Gilbert, L. A., and Weissman, J. S. (2019). *Exploring genetic interaction manifolds constructed from rich single-cell phenotypes.* Science, 365(6455):786–793.
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- Srivatsan, S. R., McFaline-Figueroa, J. L., Ramani, V., Saunders, L., Cao, J., Packer, J., Pliner, H. A., Jackson, D. L., Daza, R. M., Christiansen, L., Zhang, F., Steemers, F., Shendure, J., and Trapnell, C. (2020). *Massively multiplex chemical transcriptomics at single-cell resolution.* Science, 367(6473):45–51.
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- Frangieh, C. J., Melms, J. C., Thakore, P. I., Geiger-Schuller, K. R., Ho, P., Luoma, A. M., Cleary, B., Jerby-Arnon, L., Malu, S., Cuoco, M. S., Zhao, M., Ager, C. R., Rogava, M., Hovey,
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L., Rotem, A., Bernatchez, C., Wucherpfennig, K. W., Johnson, B. E., Rozenblatt-Rosen, O.,
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Schadendorf, D., Regev, A., and Izar, B. (2021). *Multimodal pooled Perturb-CITE-seq screens in
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patient models define mechanisms of cancer immune evasion*. Nat. Genet., 53(3):332–341.
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- Jiang, L., Dalgarno, C., Papalexi, E., Mascio, I., Wessels, H.-H., Yun, H., Iremadze, N., Lithwick Yanai, G., Lipson, D., and Satija, R. (2024a). *Systematic reconstruction of molecular pathway signatures using scalable single-cell perturbation screens.* bioRxiv, page 2024.01.29.576933.
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- McFaline-Figueroa, J. L., Srivatsan, S., Hill, A. J., Gasperini, M., Jackson, D. L., Saunders,
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L., Domcke, S., Regalado, S. G., Lazarchuck, P., Alvarez, S., et al.
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(2024). *Multiplex single cell chemical genomics reveals the kinase dependence of the response to targeted therapy*. Cell Genomics, 4(2)
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- Szałata, A., Benz, A., Cannoodt, R., Cortes, M., Fong, J., Kuppasani, S., Lieberman, R., Liu, T., Mas-Rosario, J. A., Meinl, R., Nourisa, J., Tumiel, J., Tunjic, T. M., Wang, M., Weber, N., Zhao, H., Anchang, B., Theis, F. J., Luecken, M. D., Burkhardt, D. B. (2024). *A benchmark for prediction of transcriptomic responses to chemical perturbations across cell types.* NeurIPS, (38).
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Datasets with fixed splits have their splits included as `.csv` files with two colums: the first corresponds to the cell ID (which is the `.obs_names` of the respective h5ad file) and second to the split value (`train`, `val`, `test`). Some datasets contain multiple splits in which case the split files are in a `tar.gz`.
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croissant.json
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},
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"@type": "sc:Dataset",
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"name": "PerturBench",
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"description": "A dataset containing single-cell RNA-seq data with genetic and chemical perturbations.",
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"url": "https://huggingface.co/datasets/altoslabs/perturbench",
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"license": "https://creativecommons.org/licenses/by-nc/4.0/deed.en",
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"citation": "Yan Wu, Esther Wershof, Sebastian M Schmon, Marcel Nassar, B\u0142a\u017cej Osi\u0144ski, Ridvan Eksi, Zichao Yan, Rory Stark, Kun Zhang, and Thore Graepel (2025). PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis. Proceedings of the 39th Conference on Neural Information Processing Systems (NeurIPS 2025).",
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"description": "This dataset is a modified version of the Srivatsan20 dataset published by Srivatsan et al. via GEO:GSE139944. It contains 188 chemical perturbations subset to the highest dose only applied across 3 cell types. The full data preprocessing notebook can be found at: https://github.com/altoslabs/perturbench/blob/main/notebooks/neurips2025/data_curation/curate_Srivatsan20.ipynb.",
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"description": "This dataset is a modified version of the Norman19 dataset published by Norman et al. via GEO:GSE133344. It contains 287 genetic perturbations (131 duals) applied to k562 cells. The full data preprocessing notebook can be found at: https://github.com/altoslabs/perturbench/blob/main/notebooks/neurips2025/data_curation/curate_Norman19.ipynb.",
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"encodingFormat": "application/gzip",
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| 141 |
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"cr:includes": [
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"norman19-h5ad",
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"norman19-cpa-h5ad",
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"norman19-cpa-splits"
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]
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},
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{
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"@type": "sc:FileSet",
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"@id": "frangieh21",
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| 150 |
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"name": "Frangieh21",
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| 151 |
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"description": "This dataset is a modified version of the Frangieh21 dataset published by Frangieh et al. via https://singlecell.broadinstitute.org/single_cell/study/SCP1064/multi-modal-pooled-perturb-cite-seq-screens-in-patient-models-define-novel-mechanisms-of-cancer-immune-evasion. It contains 248 genetic perturbations applied to 3 melanoma cell models. The full data preprocessing notebook can be found at: https://github.com/altoslabs/perturbench/blob/main/notebooks/neurips2025/data_curation/curate_Frangieh21.ipynb.",
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"encodingFormat": "application/gzip",
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"cr:includes": [
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"frangieh21-h5ad",
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"frangieh21-csv"
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]
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},
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{
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"@type": "sc:FileSet",
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"@id": "mcfalinefigueroa23",
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| 161 |
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"name": "McFalineFigueroa23",
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| 162 |
-
"description": "This dataset is a modified version of the McFalineFigueroa23 dataset published by McFaline-Figueroa et al. via GEO:GSE225775. It contains ~200 perturbations applied across 6 cell lines and 5 cytokine treatments (30 unique biological states). The data preprocessing occured in two steps and both files can be found at: https://github.com/altoslabs/perturbench/blob/main/notebooks/neurips2025/data_curation/ with the curate_McFalineFigueroa_2023 prefix.",
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"encodingFormat": "application/gzip",
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"cr:includes": [
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"mcfalinefigueroa23-h5ad",
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"mcfalinefigueroa23-splits"
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]
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},
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{
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"@type": "sc:FileSet",
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"@id": "jiang24",
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"name": "Jiang24",
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| 173 |
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"description": "This dataset is a modified version of the Jiang24 dataset published by Jiang et al. via https://zenodo.org/records/14518762. It contains 525 genetic perturbations applied across 3 cell lines and 5 chemical treatments (15 unique biological states). The data preprocessing occured in two steps and both files can be found at: https://github.com/altoslabs/perturbench/blob/main/notebooks/neurips2025/data_curation/ with the curate_Jiang_2024 prefix.",
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"encodingFormat": "application/gzip",
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"cr:includes": [
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"jiang24-h5ad",
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"jiang24-csv"
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]
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},
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{
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"@type": "sc:FileSet",
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"@id": "op3",
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"name": "OP3",
|
| 184 |
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"description": "This dataset is a modified version of the OpenProblems perturbation prediction challenge dataset that a Kaggle competition part of the NeurIPS 2023 competition track by Burkhardt et al. via https://openproblems.bio/benchmarks/perturbation_prediction?version=v1.0.0. It contains 144 chemical perturbations applied to PBMCs with at least 4 mature cell types. The data preprocessing can be found at: https://github.com/altoslabs/perturbench/blob/main/notebooks/neurips2025/data_curation/curate_op3.ipynb.",
|
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"encodingFormat": "application/gzip",
|
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"cr:includes": [
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"op3-h5ad",
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"op3-csv"
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]
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}
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],
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"recordSet": [
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{
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"@type": "cr:RecordSet",
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"name": "treatment_classification",
|
| 196 |
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"description": "Records for the perturbation response prediction task using scRNA-seq datasets stored in h5ad files. Records are sourced from six manifest files found in the distribution list, with one file per dataset, and stored in the `.obs` slot of each h5ad file. The perturbation identity is the 'condition' column, with the `control` value reserved for the DMSO or non-targeting CRISPR controls. The cell type is stored in the `cell_type` column. Additional cytokine or chemical treatments are stored in the `treatment` column. Splits are defined dynamically by the PerturBench library.",
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"field": [
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{
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"@type": "cr:Field",
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"name": "condition",
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"description": "Chemical or genetic perturbation applied to cells. This is the key conditioning label for the perturbation response prediction task.",
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"dataType": "sc:Text"
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},
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{
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"@type": "cr:Field",
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"name": "cell_type",
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"description": "Cell line or cell type of the sample.",
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"dataType": "sc:Text"
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},
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{
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"@type": "cr:Field",
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"name": "treatment",
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"description": "Additional cytokine or chemical treatments applied to cells, used together with `cell_type` to define the biological state of a sample.",
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"dataType": "sc:Text"
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}
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]
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}
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]
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}
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norman19_cpa_hvg_normalized_curated.h5ad.gz → norman19_cpa_hvg_normalized_curated.h5ad
RENAMED
|
@@ -1,3 +1,3 @@
|
|
| 1 |
version https://git-lfs.github.com/spec/v1
|
| 2 |
-
oid sha256:
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| 3 |
-
size
|
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|
| 1 |
version https://git-lfs.github.com/spec/v1
|
| 2 |
+
oid sha256:428a4ee1ddb7476bb7a8c378e821763ec6f71e560434685553066bc66bda37d8
|
| 3 |
+
size 838510096
|