query stringlengths 1 1.57k | pos stringlengths 1 18k | score float64 0.75 0.95 |
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Physiologic monitoring goals for the critically ill patient. | Definition of the appropriate therapeutic goals for physiologic monitoring of patients postoperatively was approached by analyzing more than 50,000 values of the 20 most commonly monitored variables in a series of 113 critically ill patients throughout their immediate postoperative course. In general, normal values wer... | 0.829458 |
3beta-Hydroxysteroid dehydrogenase activity in human fetal membranes. | A 3beta-hydroxysteroid dehydrogenase (3betaHSD) was demonstrated in term human fetal membranes (chorion and amnion) with both dehydroepiandrosterone (3beta-hydroxy-5-androsten-17-one) and pregnenolone (3beta-hydroxy-5-pregnen-20-one as substrates, and the subcellular distribution substrate and nucleotide specificity of... | 0.886692 |
beta-D-galactosidase activities in juvenile GM1-gangliosidosis. | beta-Galactosidase activity was investigated in one case of juvenile GM1-gangliosidosis. This patient exhibited normal activity of the neutral form of beta-galactosidase (measured as beta-glucosidase activity) and normal pH curve of residual acid beta-galactosidase activity in leucocytes and fibroblasts. A shift toward... | 0.865906 |
Treatment of acute otitis media of infancy with cefaclor. | The emergence of ampicillin-resistant Haemophilus as a clinical problem in otitis media necessitates a search for alternative, effective therapy. An orally absorbable cephalosporin derivative, cefaclor, is equally effective in vitro against ampicillin-susceptible and -resistant Haemophilus and against other bacteria th... | 0.878417 |
[Non-enzymatic fibrinolytic agents]. | Non-enzyme fibrinolytic agents include pharmacological agents which are active in vivo but inactive in vitro and synthetic chemical compounds which when added to blood or plasma in vitro directly induce fibrinolysis. There are a number of drugs with a short duration of action such as adrenalin, nicotinic acid, vasopres... | 0.8072 |
The spectrum of vasculitis: clinical, pathologic, immunologic and therapeutic considerations. | Vasculitis is a clinicopathologic process characterized by inflammation and necrosis of blood vessels. Certain disorders have vasculitis as the predominant and most obvious manifestation, whereas others have various degrees of vasculitis in association with other primary disorders. Within the entire spectrum of vasculi... | 0.832952 |
Nitrogen assimilation in Rhodopseudomonas acidophila. | Rhodopseudomonas acidophila strain 7050 assimilated ammonia via a constitutive glutamine synthetase/glutamate synthase enzyme system. Glutamine synthetase had a Km for NH+4 of 0.38 mM whilst the nicotinamide adenine dinucleotide linked glutamate synthase had a Km for glutamine of 0.55 mM. R. acidophila utilized only a ... | 0.844061 |
[The influence of umbilical cord structure on the course of pregnancy and parturition (author's transl)]. | A series of 549 not selected placentas and umbilical cords were examined to show the influence of the different development of the umbilical cord structure on the umbilical cord perfusion and the course of parturition. For this purpose the quantity of Wharton's jelly, the spiraling of the umbilical vessels as well as t... | 0.87397 |
Absorption of magnesium by the young steer. | 1. Steers with rumen and simple duodenal cannulas were allowed to graze pasture or were given diets of dried grass or flaked maize with or without hay. For an experiment a solution or suspension of magnesium chloride, polyethylene glycol (molecular weight 4000) and either 144Ce (as cerous chloride) or chromic oxide was... | 0.851733 |
Dimeric nature and amino acid compositions of homogeneous canine prostatic human liver and rat liver acid phosphatase isoenzymes. Specificity and pH-dependence of the canine enzyme. | Two isoenzymes of rat liver acid phosphatase (orthophosphoric-monoester phosphohydrolase (acid optimum) EC 3.1.3.2) have been purified to homogeneity, at least one of these for the first time. Both of the rat liver isoenzymes have identical specific activities towards p-nitrophenyl phosphate. Molecular weights of the n... | 0.917258 |
The pH-dependence of the non-specific esterase activity of carboxypeptidase A. | The hydrolysis of the following 6 esters by bovine pancreatic carboxypeptidase A (peptidyl-L-amino-acid hydrolase, EC 3.4.12.2) has been investigated over the range pH 5--10 at 25 degrees C, ionic strength 0.2: CH3CO2CHRCO2H (R = C6H5 (ester 3), C6H5CH2 (ester 4), 4-NO2C6H4CO2CHRCO2H (R = C6H5 (ester 5), C6H5CH2 (ester... | 0.900929 |
Blockade by N-methylhydroxylamine of activation of guanylate cyclase and elevations of guanosine 3',5'-monophosphate levels in nervous tissues. | Hydroxylamine and N-methylhydroxylamine prevented the activation of soluble guanylate cyclase by the endogenous activator as well as by nitroso compounds such as N-methyl-N'-nitro-N-nitrosoguanidine or nitroprusside, while other derivaties of hydroxylamine were ineffective. Hydroxylamine and N-methylhydroxylamine did n... | 0.869434 |
Treatment of aplastic anaemia by antilymphocyte globulin with or without marrow infusion. | Forty-one patients, suffering from severe aplastic anaemia were treated either with ALG alone (27 patients) or ALG followed by infusion of allogeneic bone marrow (14 patients). Eighteen patients (67 per cent) are presently alive after ALG alone at over 100 to over 550 days. Fourteen (52 per cent) showed sustained impro... | 0.837318 |
Sphingolipid composition and catabolism in human fetal tissues. | Human fetal tissues derived from prostaglandin-induced abortuses (9--18 wk fertilization age) have been utilized to evaluate sphingolipid composition and catabolism. Sphingolipid composition (lipid-hexose, sulfatide, and lipid-bound NANA) was assessed in fetal brain. Sphingolipid catabolism was evaluated in fetal lung ... | 0.91356 |
Enzyme reactions of ATP studied by positional isotope exchange. | Reversible gamma-PO3 transfer in ATP reactions can be recognized by exchange of 18O from the beta,gamma-bridge position to the beta-P-nonbridge positions: (see article). Such intramolecular exchange is less demanding for the detection of the bond cleavage than the usual ATP:ADP isotope exchange because it does not requ... | 0.826989 |
Isolation and some properties of two deoxyribonucleases from a snail, Achatina fulica. | 1. Two main DNases were found in the dried liver extract of a snail, Achatina fulica. They were purified by the phosphocellulose batch method and by phosphocellulose column chromatography. The enzyme eluted earlier from the phosphocellulose column was designated as Achatina DNase-1 and the other as Achatina DNase-2. DN... | 0.879144 |
Purification of soluble guanylate cyclase from rat lung. | The soluble form of guanylate cyclase from rat lung has been purified approximately 23,000-fold to homogeneity by isoelectric precipitation, GTP-Sepharose chromatography, and preparative gel electrophoresis. A single protein-staining band is observed after analytical gel electrophoresis on either 4 or 7.5% polyacrylami... | 0.889556 |
Pyridoxal phosphatase: cytochemical localization in GERL and other organelles of rat neurons. | A phosphatase, hydrolyzing pyridoxal-5-phosphate (P5P), a physiologically active component of the vitamin B6 complex and an essential co-enzyme in the synthesis of neurotransmitters, has been localized cytochemically in the perikarya of neurons in the peripheral, autonomic and central nervous systems of the rat. Neuron... | 0.895585 |
The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions. | Lymphocytes of the mouse intestinal mucosa, identified in tissue sections or purified suspensions of intraepithelial lymphocytes as T cells (gut T lymphocytes [GTL]), were studied in normal mice or in beige mice (the equivalent of the Chediak-Higashi syndrome in man, characterized by giant granules in various cell type... | 0.840963 |
Autoxidation of polysorbates. | Aqueous solutions of polysorbate 20 undergo autoxidation on storage, with the peroxide number increasing and subsequently decreasing again, the acidity increasing continuously, the pH and surface tension falling and tending to level off, and the cloud point dropping sharply until turbidity begins at room temperature. T... | 0.833393 |
Evidence for anionic cation transport of lithium, sodium and potassium across the human erythrocyte membrane induced by divalent anions. | 1. The passive net transport of Li+ and Na+ across the human red cell membrane was accelerated by the divalent anions carbonate, sulphite, oxalate, phosphite and malonate. Phthalate, maleate, sulphate and succinate were found additionally to stimulate downhill transport of K+. Marked differences in anion efficacy and s... | 0.891494 |
Beta-adrenergic receptors: regulatory role of agonists. | Direct radioligand binding studies have been used to probe the molecular mechanisms whereby agonist catecholamines regulate the function of beta-adrenergic receptors in a model system, the frog erythrocyte. The unique characteristics of agonist as opposed to antagonist action are first, the ability to stimulate the ade... | 0.84214 |
Pneumococcal polysaccharide immunization in infants and children. | By using indirect hemagglutination, the antibody responses of normal infants and children to an octavalent pneumococcal vaccine that contained pneumococcal polysaccharide types 1, 3, 6, 7, 14, 18, 19, and 23 were evaluated. By 2 years of age, there was a significant rise in hemagglutination titers to all the polysaccha... | 0.875267 |
Phosphorus-31 NMR studies of E. coli ribosomes. | Phosphorus-31 nuclear magnetic resonance spectra, relaxation times and nuclear Overhauser (NOE) enhancement have been measured for E. coli ribosomes, subunits and rRNA. NOE and T1 experiments reveal that the phosphorus relaxation in this organelle is largely dipolar in origin. Moreover these results imply the presence ... | 0.896073 |
Polarographic estimation of antazoline hydrochloride. | The dc-polarographic investigation of antazoline hydrochloride in aqueous acidic media is described. Using potassium chloride-hydrochloric acid mixture as the supporting electrolyte (pH = 3.25), antazoline hydrochloride was electrochemically reduced at the dropping mercury electrode, with the production of two waves wi... | 0.923909 |
Food-stimulated acid secretion measured by intragastric titration with bicarbonate in patients with duodenal and gastric ulcer disease and in controls. | Gastric acid secretion stimulated by a normally eaten beefsteak meal was measured for 4 h in 16 patients with duodenal ulcer disease (DU), in 9 patients with gastric ulcer disease (GU), and in 14 controls by intragastric titration with bicarbonate to a constant pH 5.5. Reproducibility of the method investigated in 6 DU... | 0.891823 |
HLA-Bw52 in Takayasu disease. | Takayasu disease is characterized by a pulseless condition which most often occurs in young females from Asian or South American areas. The cause of this disease remains obscure. Recently we encountered monozygotic, Japanese identical twin sisters, both of whom were diagnosed as having Takayasu disease. A genetically r... | 0.888043 |
Purification and properties of rennin-like enzyme from Aspergillus ochraceus. | An active milk-clotting enzyme was purified some 40-fold from culture supernatant of Aspergillus ochraceus. The purification steps included ammonium sulfate precipitation, G-100 Sephadex gel filtration, and ion exchange chromatography, using DEAE Cellulose column. The enzyme exhibited milk-clotting activity and proteol... | 0.754771 |
Pressure passive cerebral blood flow and breakdown of the blood-brain barrier in experimental fetal asphyxia. | Cerebral blood flow (CBF) was studied in non-exteriorized near-term sheep fetuses using the radioactive microsphere technique. By partially occluding the umbilical vessels for a period of 1--1 1/2 hours a progressive and severe asphyxia with a final arterial pH of 6.90 was achieved. Varying the mean arterial blood pres... | 0.855285 |
The in vitro interaction of Trypanosoma cruzi bloodstream forms and mouse peritoneal macrophages. | The uptake and further development of bloodstream forms from T. cruzi Y and CL strains in mouse peritoneal macrophages have been investigated. Parasites from the Y strain (which present predominance of slender forms) are 20 to 30-fold more infective to macrophages than those from CL strain in which stout forms highly p... | 0.846116 |
Influence of pH on elastic deformability of the human erythrocyte membrane. | Fresh human blood was diluted 1:5000 in buffered saline-sucrose solution and titrated to a pH varying from 4.5 to 10.5 with 0.1 N HCl or 0.1 N NaOH. Circular regions of the membrane of individual cells were then deformed at 25 degrees C by aspiration into a micropipette having an internal tip diameter of 0.9-1.4 micron... | 0.911845 |
Importance of chloride for acute inhibition of renin by sodium chloride. | To evaluate the contribution of chloride to acute renin inhibition by sodium chloride, plasma renin activity (PRA) was measured before and after peripheral venous infusion of NaCl, NaHCO3, NaBr, NaNO3, lysine monohydrochloride, or lysine glutamate in NaCl-deprived rats. In contrast to controls and animals infused with ... | 0.900332 |
[New results on ageing of connective tissue (author's transl)]. | Some new results on ageing of connective tissue are demonstrated, regarding not only mesenchymal, but also parenchymal organs of human and rat (both sexes). These results show that ageing of connective tissue is more a dynamic process (with measurable metabolic parameters of the several connective tissue cells and thei... | 0.890577 |
Behavior therapy, supportive psychotherapy, imipramine, and phobias. | In a controlled outcome study of phobias, 111 adult patients (69% women, 31% men) received a course of 26 weekly treatment sessions consisting of (1) behavior therapy and imipramine hydrochloride (2) behavior therapy and placebo, or (3) supportive psychotherapy and imipramine. Patients were classified as agoraphobic, ... | 0.881656 |
Effect of the mouse mutants testicular feminization and sex reversal on hormone-mediated induction and repression of enzymes. | The mouse mutants testicular feminization and sex reversal have been used to investigate hormone-mediated induction and repression of enzymes. Tfm/Y animals were already known to be androgen insensitive, rendering the androgen-inducible enzymes ADH and beta-glucuronidase noninducible because of an inherited deficiency ... | 0.882681 |
Cerebral oxidized and reduced nicotinamide-adenine dinucleotide phosphate and glucose 6-phosphate dehydrogenase in mice during exposure to high oxygen pressure. | NADP+, NADPH and glucose 6-phosphate dehydrogenase were determined in the cerebral cortex of mice exposed to high O2 pressure for 0, 8 and 16 min. These time intervals corresponded to 0, 50 and 100% of the CT50 (the time taken for 50% of the mice to convulse). Cerebral NADP+, NADPH and glucose 6-phosphate dehydrogenase... | 0.874516 |
Zymogen activation in serine proteinases. Proton magnetic resonance pH titration studies of the two histidines of bovine chymotrypsinogen A and chymotrypsin Aalpha. | Reversible unfolding of bovine chymotrypsinogen A in 2H2O either by heating at low pH or by exposure to 6 M guanidinium chloride results in the exchange of virtually all the nitrogen-bound hydrogens that give rise to low-field 1H NMR peaks, without significant exchange of the histidyl ring Cepsilon1 hydrogens. These pr... | 0.900808 |
Sequence of reactions which follows enzymatic oxidation of allylglycine. | The pathway following flavoprotein-catalyzed oxidation of allylglycine (2-amino-4-pentenoate) has been studied and found to be dependent on the incubation conditions. In N-2-hydroxyethyl-N'-2-ethanesulfonic acid (Hepes) buffer, the oxidation product 2-iminium-4-pentenoate predominantly reacts to form 2-amino-2,4-pentad... | 0.820812 |
The role of Zn(II) in calf intestinal alkaline phosphatase studied by the influence of chelating agents and chemical modification of histidine residues. | Alkaline phosphatase from calf intestine (orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1) is reversibly inhibited at pH 8.0 by incubation with chelating agents. Complete reactivation may be achieved by stoichiometric addition of Zn2+. Atomic absorption spectrometry was used to demonstrate the... | 0.889507 |
Laser Raman studies on cobrotoxin. | Laser Raman spectra of cobrotoxin under various conditions have been obtained. Comparison of the spectra of native cobrotoxin in lyophilized form and in aqueous solution indicates that the secondary structures of cobrotoxin are not significantly affected by the removal of the aqueous solvent. On going from the native t... | 0.899228 |
Collagen-induced platelet aggregation and release. I Effects of side-chain modifications and role of arginyl residues. | To investigate the mechanisms governing collagen interaction with blood platelets, the effects of side-chain modifications on collagen-induced platelet aggregation and release of serotonin were studied. Since many chemical modifications alter the ability of collagen to form fibers that, according to current theory, may... | 0.930291 |
Conditions limiting the use of ionophore A23187 as a probe of divalent cation involvement in biological reactions. Evidence from the slow fluorescence quenching of type A spinach chloroplasts. | The conditions under which ionophore A23187 can be used as a probe of Mg2+ involvement in the reactions of intact (Type A) spinach chloroplasts have been investigated by monitoring ionophore-induced reversal of slow fluorescence quenching. The following observations were made: (1) A23187-dependent reversal of quenching... | 0.925748 |
Effect of salts on D-glycerate dehydrogenase kinetic behavior. | Bovine liver D-glycerate dehydrogenase (D-glycerate:NAD (NADP) oxidoreductase, EC 1.1.1.29) adapts its kinetic behaviour to a sequential mechanism. The presence of NaCl causes an appreciable variation in the Km and V values. relative to the both substrates in the hydroxypyruvate/D-glycerate dehydrogenase/NADH system, w... | 0.884158 |
Characteristics of the contingent negative variation in patients suffering from specific phobias. | The essential clinical feature of phobic neurosis is the anticipatory fear of certain objects and situations. Since an important factor in the generation of the contingent negative variation (CNV) is the anticipation of the imperative stimulus, records of CNVs were used as an indicator of electrocortical activity in a ... | 0.856342 |
Brain alpha-adrenergic receptors: comparison of [3H]WB 4101 binding with norepinephrine-stimulated cyclic AMP accumulation in rat cerebral cortex. | The ability of a series of adrenergic agents to displace the binding to brain membranes of [3H]WB 4101, a potent alpha-adrenergic antagonist (WB 4101 = 2-[2-(2,6-dimethoxyphenoxy)ethylaminomethyl]-1,4-benzodioxane hydrochloride), has been compared with the potency of these agents in stimulating or inhibiting the alpha-... | 0.909157 |
Cellulase and beta-glucosidase production by a basidiomycete species. | The optimisation of cellulase and beta-glucosidase production by a basidiomycete species was studied and cellulase and cellobiase production by this and Trichoderma viride (and its mutants) in shake flasks were compared. The former produced an active cellulase comparable to that of T. viride when tested on filter paper... | 0.914023 |
The American Cleft Palate Association: its first 36 years. | History involves memory, and sometimes memory is faulty. History requires documentation, and sometimes documents cannot be found. History demands winnowing, and sometimes the wheat and the chaff cannot be completely separated. History is an assembly of details, and details may become burdensome. History is a challenge,... | 0.814983 |
Sympathetic and parasympathetic components of reflex cardiostimulation during vasodilator treatment of hypertension. | 1. Haemodynamic responses to diazoxide (300 mg intravenously) were studied in 15 hypertensive patients before and after chronic beta-adrenoreceptor blockade by 320 mg of propranolol daily. After diazoxide alone, mean arterial pressure and total peripheral resistance were lowered by 24 +/- 3 and 35 +/- 5% (mean +/- SEM)... | 0.769543 |
Localization of putative transmitters in the hippocampal formation: with a note on the connections to septum and hypothalamus. | Biochemical assays on microdissected samples, denervation studies, subcellular fractionation, and light and electron microscopic autoradiography of high affinity uptake have been performed to study the cellular localization of transmitter candidates in the rat hippocampal formation. High affinity uptake of glutamate an... | 0.817477 |
Isolation and characterization of the acidic phosphoproteins of 60-S ribosomes from Artemia salina and rat liver. | Eucaryotic L7/L12-type proteins are present in ethanol/salt extracts (P1 protein) of ribosomes from Artemia salina and rat liver. These proteins are partially phosphorylated and occur in two forms of closely related structure: a major form eL12 having methionine at the N-terminal position and a minor form of eL12 (eL12... | 0.862642 |
Comparison of disposition and effect of timolol and propranolol on exercise tachycardia. | The kinetic disposition and beta-adrenergic blocking action in relation to plasma level of a single oral dose of either timolol or propranolol has been compared in healthy male volunteers. The disposition profiles clearly disclosed different properties of the two drugs, although their half-lives were similar. The avail... | 0.924298 |
A difference in effects of physiological Ca2+ concentrations on activity of guanylate cyclase preparations obtained from the taenia caecum of guinea pig and from the longitudinal muscle of rat duodenum. | A cholinergic stimulant, butyltrimethylammonium bromide and serotonin increased the tissue levels of cyclic GMP in the taenia caecum of guinea pig but not those in the longitudinal muscle of rat duodenum. On the other hand, physiological Ca2+ concentrations enhanced the activity of a guanylate cyclase preparation obtai... | 0.904137 |
A comparison of socio-demographic and fertility characteristics of women sterilized in hospitals and camps. | Socio-demographic characteristics of 5846 women undergoing sterilization in hospitals and 1752 women undergoing sterilization in camps in India are analyzed. The average age of women accepting sterilization was 29.8 years; the mean number of living children was 4.2. Women sterilized in hospitals were of significantly h... | 0.893679 |
[Presynaptic receptor systems in central noradrenergic neurons]. | Slices of rat occipital cortex, hypothalamus or cerebellar cortex were stimulated either electrically or by high potassium (in few experiments by tyramine). 1. Electrical or potassium stimulation elicit physiologically noradrenaline release in contrast to tyramine. 2. Stimulation-induced overflow of tritium, reflecting... | 0.80828 |
Extractability of cell wall polysaccharide from lactobacilli and streptococci by autoclaving and by dilue acid. | Autoclaving cell wall of Streptococcus mutans Ingbritt for 15 min under the Rantz and Randall conditions released one-tenth of the total cell wall carbohydrate, whereas two-thirds was extracted after autoclaving for 180 min. The extract contained the serotype c-specific antigen but lacked the lipoteichoic acid componen... | 0.878084 |
In vitro cultivation of leprosy bacilli in hyaluronic acid-based medium. 2. Progress and developing concept of the role of hyaluronic acid suggested by culture and armadillo infection studies. | Progress is summarized relating to the verification, identification of M. leprae and understanding of the process of adaptation the pathogen passes through before in vitro growth takes place. It is recognized that hyaluronic acid apparently does not serve as a source of energy but the possibility is presented that it p... | 0.843729 |
Mixing technique for study of oxygen-hemoglobin equilibrium: a critical evaluation. | In the mixing technique for study of oxygen-hemoglobin equilibrium, the O2 saturation (SO2) of a blood mixture is calculated from the volume ratio at which an oxygenated sample is mixed with a deoxygenated sample, and the PO2 in the mixture is measured polarographically. Any predetermined level of SO2 may be obtained b... | 0.884465 |
Direct fluorometric determination of a dissociation constant as low as 10(-10) M for the subtilisin BPN'--protein proteinase inhibitor (Streptomyces subtilisin inhibitor) complex by a single photon counting technique. | It was found that an increase in fluorescence intensity at 340 nm is observed on the binding of Streptomyces subtilisin inhibitor (SSI) with subtilisin BPN' in the pH range 6--10. The dissociation constant, Ki, of the enzyme-inhibitor complex was determined as a function of pH and temperature by direct fluorometric tit... | 0.931075 |
Purification and properties of an NAD(P)+-linked formaldehyde dehydrogenase from Methylococcus capsulatus (Bath). | Crude soluble extracts of Methylococcus capsulatus strain Bath, grown on methane, were found to contain NAD(P)+-linked formaldehyde dehydrogenase activity. Activity in the extract was lost on dialysis against phosphate buffer, but could be restored by supplementing with inactive, heat-treated extract (70 degrees C for ... | 0.923876 |
Content uniformity of potent drugs in tablets. | The type of distribution of low dosage drugs that occurs in batches of commercially available tablets has been examined. The uniformity of content of ethinyloestradiol tablets 10 micrograms B.P. from different sources, assessed by single tablet assay showed that three batches exhibited some positive skewness and one ma... | 0.858408 |
A comparison of the cardiovascular effects of centrally administered clonidine and adrenaline in the anaesthetized rat. | Intracerebroventricular (i.c.v.) injections of clonidine and adrenaline-induced hypotension and bradycardia in urethane anaesthetized spontaneous hypertensive rats. The hypotension induced by clonidine (3 microgram i.c.v.) was antagonized by pretreatment with the alpha-antagonists piperoxan, which also antagonized clon... | 0.873847 |
Characterization of Rauscher murine leukemia virus envelope glycoprotein receptor in membranes from murine fibroblasts. | Plasma membrane preparations from KA31 (mouse) cells contained receptors for the binding of Rauscher murine leukemia virus (R-MuLV) envelope glycoprotein, gp70. This binding was demonstrated by gel filtration of a mixture of the microsomal fraction of the cells and 125I-labeled gp70. A rapid and convenient assay was de... | 0.878919 |
Relationship between gastric secretion and serum gastrin levels in dogs anesthetized with morphine and urethane. | The serum levels of immunoreactive gastrin (IRG) and secretion of gastric juice were simultaneously determined in dogs anesthetized with morphine and urethane. There was a significant positive linear correlation between secretion and serum IRG level in these dogs. Serum IRG level and gastric secretion were reduced by b... | 0.906893 |
Phosphorylation and dephosphorylation of spectrin. | The phosphorylation of spectrin polypeptide 2 is thought to be involved in the metabolically dependent regulation of red cell shape and deformability. Spectrin phosphorylation is not affected by cAMP. The reaction in isolated membranes resembles the cAMP-independent, salt-stimulated phosphorylation of an exogenous subs... | 0.887064 |
[Drug interactions]. | Every alteration of the effect of a drug within the human body due to substances introduced from outside are considered drug interactions. Several types of these mutual actions are differentiated. They can be influenced with varying success according to the site of the interaction. An unusual variant of the interaction... | 0.769369 |
Localization of the site of adenylylation of glutamine synthetase by electron microscopy of an enzyme-antibody complex. | Antibodies to the nucleosidel,N(6)-ethenoadenosine have been used to localize the site of adenylylation of the glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] of Escherichia coli. Antibodies were induced in rabbits by injection of a bovine albumin-ethenoadenosine conjugate. The resulting ant... | 0.86685 |
Transport of model compounds across the peritoneal membrane in the rat. | The absorption into the systemic circulation of compounds administered intraperitoneally in large volumes was investigated in the rat. The influence on absorption of molecular weight, lipid-water partition coefficient (K), and dissociation constant (pKa) was studied. Nine neutral compounds ranging in molecular weight f... | 0.839558 |
The peripheral platelet count in response to adrenergic alpha-and beta-1-receptor stimulation. | The aim of the present work was to investigate the effect of adrenergic alpha- and beta-1-receptor stimulation on the peripheral platelet count. The experiments were carried out on 8 healthy male volunteers using radioisotopically labelled platelets. 3 subjects received i.v. infusions of adrenaline (0.09 microgram X kg... | 0.923382 |
Difference in the effect of bucolome on the hepatic transport maximum of sulfobromophthalein and indocyanine green. | The effects of bucolome (BC, 1-cyclohexyl-5-n-butyl-2,4,6-trioxoperhydropyrimidine, a non-steroid antiinflammatory agent), a potent choleretic, on the maximal biliary excretion rates (Tm) of sulfobromophthalein (BSP) and indocyanine green (ICG) were investigated in rats. With continuous infusion of BSP or ICG, Tm and b... | 0.890153 |
Metabolism of arachidonic acid by platelets: utilization of arachidonic acid by human platelets in presence of linoleic and dihomo-gamma-linolenic acids. | In vitro human platelet prostaglandin synthesis has been studied from added radioactive arachidonic acid (i) as function of substrate concentration, (ii) as function of platelet concentration and (iii) as function of pH. Platelets, as in platelet rich plasma when labelled with arachidonic acid, washed and treated with ... | 0.923517 |
[Histamine and its role in peptic gastric diseases: the discovery of histamine-H2-receptor antagonists]. | For the definition of histamine receptors the following prerequisites must be fulfilled: (1) Course of dose-response curves according to the mass-action law; (2) parallel displacement of these curves to the right in the presence of antagonists; (3) inhibition only by specific histamine antagonists; (4) slope of a Schil... | 0.808503 |
Illicit drug use among urban adolescents. A decade in retrospect. | Over the past decade (1967 to 1977), 76,000 adolescents were screened for a history and somatic signs of illicit drug use at a detention center for juveniles and at an adolescent inpatient unit of a university-affiliated hospital. Dramatic changes in the patterns of drug abuse are reported. Opiate use was prominent in ... | 0.851215 |
Continuous intrapartum monitoring of fetal scalp pH. | Forty patients were monitored intrapartum with a continuous fetal scalp tissue pH electrode in the mean time of 2.39 hours. The monitoring records were considered "accurate" with good correlation to the intermittent fetal scalp capillary pH values in 76.9 per cent. The correlation coefficient was 0.74. The "accuracy" i... | 0.904952 |
[The solubilizer of diazepam (valium)--its action on respiration (author's transl)]. | Investigations carried out in volunteers showed that when compared with physiological saline the solubilizer of diazepam caused hyperventilation. Among the constituents of the solubilizer propylene glycol and ethyl alcohol have to be excluded, likely benzyl alcohol was due to the respiratory response. Benzyl alcohol ha... | 0.892712 |
[Osmotic colloidal pressure: measurement and clinical importance]. | Knowledge of osmotic pressure has long existed and its practical use in the treatment of patients under intensive care has been widely developed over the past few years following the introduction of simple electronic osmometers. It is related more to plasma albumin than to globulins. It varies in relation with a certai... | 0.786788 |
Adenylate cyclase in bloodstream forms of Trypanosoma (Trypanozoon) brucei sp. | 1. The adenylate cyclase in Trypanosoma brucei is located in the plasma membrane. 2. A partial kinetic analysis of the properties of the enzyme revealed a Km for ATP of 1.75 mM and a Km for Mg2+ of 4mM. 3. At low concentrations, Mg2+ activated the enzyme directly in addition to its effect of lowering the concentration ... | 0.855521 |
Yellow lupin (Lupinus luteus) aminoacyl-tRNA synthetases. Isolation and some properties of enzyme-bound valyl adenylate and seryl adenylate. | As a continuation of our studies on plant (yellow lupin, Lupinus luteus) aminoacyl-tRNA synthetases we describe here formation and some properties of valyl-tRNA synthetase-bound valyl adenylate (EVal(Val-AMP)) and seryl-tRNA synthetase-bound seryl adenylate (ESer(Ser-AMP)). Valyl-tRNA synthetase-bound valyl adenylate w... | 0.929804 |
[Electrophoretic analysis of substrate specificity of wheat alcohol dehydrogenases]. | Electrophoresis in polyacrylamide gel slabs has been used to study the isoform composition and substrate specificity of alcohol dehydrogenases in the embryo and young seedlings of the diploid wheat Triticum monococcum L., the tetraploid T. dicoccon (Schrank) Schuebl and the hexaploid T. spelta L. Three alcohol dehydrog... | 0.897252 |
[Interaction of aliphatid alcohols with cytochrome P-450 from rat liver microsomes]. | The interaction of alyphatic alcohols and cyclohexanol with cytochrome P-450 in microsomes has been investigated. All alchohols induced the modified 11 type spectral changes by mixing with microsomes. These changes are characterized by lambdamax = 412 and lambdamin = 380-382 nm in difference spectra. The dissociation c... | 0.850386 |
Prevention and reversal of isolation-induced systolic arterial hypertension in rats by treatment with beta-adrenoceptor antagonists. | 1. Rats were made hypertensive by 5 days of continuous isolation in glass metabolic cages; in the text "hypertensive" means having a systolic blood pressure greater than 145 mmHg. 2. Daily intraperitoneal injections of either propranolol (5 mg/kg) or atenolol (5 mg/kg) reduced systolic blood pressure within 3 days and ... | 0.865629 |
Effects of fluoride on in vitro calcification of tendon matrix. | Ca2+ and Pi uptake induced in vitro by a collagenous matrix derived from bovine tendon is inhibited by 1 X 10(-6) to 2 X 10(-5) M NaF and stimulated by 2 X 10(-5) to 2 X 10(-3) M NaF. Fluoride uptake occurs only over the latter concentration range. The uptake of Ca2+, Pi, and F-1 progresses toward a limiting extent at ... | 0.85228 |
Glucose-6-phosphate dehydrogenase deficiency in Sicily. Incidence, biochemical characteristics and clinical implications. | This report deals with the incidence, type and clinical implications of G6PD deficiency in Sicily. Of 3347 male subjects examined, 56 were deficient in G6PD. They were distributed throughout the island. The G6PD levels in RBC were almost zero; in leukocytes, platelets and saliva they were found to be 26%, 18% and 16%, ... | 0.852908 |
Acute effects of piretanide in normal subjects. | Acute clearance studies were performed in normal subjects to assess the actions of the new diuretic, piretanide, on renal function. The drug increased both glomerular filtration rate and effective renal plasma flow in roughly proportionate amounts, so that filtration fraction did not change. In a dosage of 2 to 3 mg, i... | 0.816419 |
Release of nickel from cooking utensils. | The release of nickel to boiling water from new and used saucepans of different material was measured. No nickel was released from aluminium, teflon and enamel. Certain amounts of nickel were released from stainless steel, but only at acid pH. | 0.829426 |
beta-Galactosidases in mouse duodenal mucosa. | beta-Galactosidase activity, in fetal mice, first appears at 16 days of gestation and has a pH optimum of 4. In postnatal development the enzyme activity of cell homogenates tends to show bimodal pH at 4 and 5.6. There are two molecular forms of the enzyme, separable both by molecular-sieve chromatography and electroph... | 0.785891 |
Affinity purification and properties of cathepsin-E-like acid proteinase from rat spleen. | A unique acid proteinase different from cathepsin D was purified from rat spleen by a method involving precipitation at pH 3.5, affinity chromatography on pepstatin-Sepharose 4B and concanavalin A-Sepharose 4B, chromatography on Sephadex G-100 and DEAE-Sephacel, and isoelectric focusing. A purification of 4200-fold ove... | 0.864173 |
Ovarian and peripheral venous blood prostaglandin F2alpha levels in pregnant and nonpregnant women. | Prostaglandin F2alpha (PGF2alpha) was measured by radioimmunoassay in human blood plasma collected from both ovarian veins and from a peripheral vein in eight pregnant and seven nonpregnant women. In the pregnant women, significantly higher levels of PGF2alpha were found in venous blood plasma taken from the ovary whic... | 0.915594 |
Effect of leukocyte hydrolases on bacteria. X. The role played by leukocyte factors, cationic polyelectrolytes, and by membrane-damaging agents in the lysis of Staphylococcus aureus: relation to chronic inflammatory processes. | A heat-stable factor present in extracts of human blood leukocytes is capable of lysing young Staphylococcus aureus at pH 5.0. Lysis is characterized by breakdown of cell-wall components as judged by electron microscopic and biochemical analysis. The leukocyte extracts can be replaced by a variety of agents known to in... | 0.794541 |
Metabolism of phenol and resorcinol in Trichosporon cutaneum. | Trichosporon cutaneum was grown with phenol or resorcinol as the carbon source. The formation of beta-ketoadipate from phenol, catechol, and resorcinol was shown by a manometric method using antipyrine and also by its isolation and crystallization. Metabolism of phenol begins with o-hydroxylation. This is followed by o... | 0.881535 |
Mannosyl transfer by membranes of Aspergillus niger: mannosylation of endogenous acceptors and partial analysis of the products. | A smooth membrane fraction of Aspergillus niger catalyzed the transfer of mannose from GDP-mannose to endogenous lipid and protein acceptors. The mannolipid was acidic, as judged by diethylaminoethyl-cellulose chromatography, and had a mobility similar to ficaprenyl phosphate on thin-layer chromatograms. Mannose transf... | 0.857724 |
Kinetic study of soybean beta-amylase. The effect of pH. | 1) Beta-Amylase [EC 3.2.1.2] was prepared from defatted hawk eye soybean flour. The enzyme concentration dependence of the initial velocity for the hydrolytic reaction was investigated at pH 5.4 in the range of the enzyme concentration from 6.6 x 10(-10) M to 5.0 x 10(-6) M. It was found that the initial velocity was p... | 0.89464 |
Ca2+-induced bioluminescence in Renilla reniformis. Purification and characterization of a calcium-triggered luciferin-binding protein. | A Ca2+-triggered luciferin-binding protein (BP-LH2) from the bioluminescent marine coelenterate, Renilla reniformis, has been purified by conventional methods. One kilogram of processed animals yields approximately 2.7 mg of pure protein with an overall yield of 55%. Physicochemical studies show that BP-LH2 is a globul... | 0.905656 |
Synthesis and use of a new spin-labeled analogue of ADP with platelet-aggregating activity. | A new spin-labeled derivative of ADP, 2-(4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxyl)thioadenosine-5'-diphosphate, has been synthesized. The compound causes both the reversible and irreversible phases of aggregation of human blood platelets at concentrations similar to those required for similar phases of aggregat... | 0.912832 |
Evidence for a high molecular weight factor(s) in serum which increases alkaline phosphatase specific activity in HeLa. | HeLa (substrain Ho) grown in serum free medium showed an increase in the specific activity of alkaline phosphatase when fetal calf serum (10%) was added to the medium (9.7 nmoles/sec/mg protein to 86.8). Under the same conditions, eight intracellular enzymes showed no increase in activity. Similar results were obtained... | 0.868865 |
The metabolism of floctafenin in man and rodents. | Floctafenin (FFn), 2,3-dihydroxypropyl--N--(8--trifluoromethyl--4--quinolyl) anthranilate, a new nonnarcotic analgesic drug, was studied in man, mice, and the isolated perfused rat liver. In all species the drug is rapidly hydrolyzed to floctafenic acid (FFa). In seven volunteer subjects who each received a single oral... | 0.830997 |
Immunological studies of T-cell receptors. II. Limited polymorphism of idiotypic determinants on T-cell receptors specific for major histocompatibility complex alloantigens. | These studies explore the extent of genetic polymorphism in the expression of anti-MHC receptors by T cells in different strains of rats. This question was approached with the use of the model of specifically induced GVH resistance in F1 rats which has been shown to reflect a specific T-cell mediated immune response ag... | 0.83171 |
Change in brain guanosine 3',5'-monophosphate (cGMP) content by thyrotropin-releasing hormone. | Thyrotropin-releasing hormone (TRH) causes a significant increase in rat cerebellar guanosine 3',5'-monophosphate (cGMP) content after parenteral administration. A smaller but still significant increase in cGMP was also observed in brain stem, whereas no significant changes were observed in cGMP in other gross brain re... | 0.877641 |
[Metabolism of carbromal during detoxication with combined hemoperfusion and hemodialysis (author's transl)]. | Combined charcoal hemoperfusion and hemodialysis was performed on three occasions in two patients with severe carbromal intoxication. The concentration of carbromal, its organic metabolites and of bromide was determined in arterial blood before and after passage of the charcoal column and behind the dialyzer cartridge.... | 0.874728 |
Beta-D-glucosidase in fractions from rat brain. | Beta-Glucosidase activity has been determined in homogenate and in centrifugation fractions of 7-day-old and adult rat brain; maximum activity was found at pH 4 and pH 5. Of the adult brain, more than 50% of the activity was concentrated in the 800-g sediment fraction (P1), while in the brain of 7-day-old rat about 20%... | 0.811068 |
Studies on the mechanisms of central action of alpha-adrenergic receptor blocking agents. | The article summarizes the results of experiments, partly published, on the central action of alpha-adrenergic receptor blocking drugs given systemically in rats. Phenoxybenzamine, phentolamine and aceperone increase utilization of noradrenaline (NA in whole brain and antagonise NA--stimulated formation of cyclic AMP i... | 0.860861 |
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