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Detecting tax evasion: a co-evolutionary approach
We present an algorithm that can anticipate tax evasion by modeling the co-evolution of tax schemes with auditing policies. Malicious tax non-compliance, or evasion, accounts for billions of lost revenue each year. Unfortunately when tax administrators change the tax laws or auditing procedures to eliminate known fraud...
During the last decades, universal economy has experienced money laundering and its destructive impact on the economy of the countries. Money laundering is the process of converting or transferring an asset in order to conceal its illegal source or assist someone that is involved in such crimes. Criminals generally att...
Lethal effects of abamectin on the aquatic organisms Daphnia similis, Chironomus xanthus and Danio rerio.
Abamectin is used as an acaricide and insecticide for fruits, vegetables and ornamental plants, as well as a parasiticide for animals. One of the major problems of applying pesticides to crops is the likelihood of contaminating aquatic ecosystems by drift or runoff. Therefore, toxicity tests in the laboratory are impor...
Avermectins (AVMs) are used worldwide in agriculture and veterinary medicine. Residues of avermectin drugs, causing toxicological effects on non-target organisms, have raised great concern. The aim of this study was to investigate the effects of AVM on the expression levels of alpha synuclein (α-Syn) and proteasomal ac...
IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter
Radiotherapy for head and neck tumors often results in persistent loss of function in salivary glands. Patients suffering from impaired salivary function frequently terminate treatment prematurely because of reduced quality of life caused by malnutrition and other debilitating side-effects. It has been previously shown...
ObjectivesThis study investigated the expression of ΔNp63α in carcinoma cell lines of the upper aerodigestive tract and their potential influence on radioresistance using a small interfering RNA (siRNA) knockdown approach.Materials and methodsFour carcinoma cell lines were investigated for the expression of the ΔNp63 i...
InAs migration on released, wrinkled InGaAs membranes used as virtual substrate
Partly released, relaxed and wrinkled InGaAs membranes are used as virtual substrates for overgrowth with InAs. Such samples exhibit different lattice parameters for the unreleased epitaxial parts, the released flat, back-bond areas and the released wrinkled areas. A large InAs migration towards the released membrane i...
By using density functional theory (DFT) calculations of the potential energy surface in conjunction with the analytical solution of the master equation for the time evolution of the adatom site distribution, we study the diffusion properties of an isolated In adatom on InxGa1−xAs wetting layers (WL) deposited on the G...
Corpus building for Mongolian language
This paper presents an ongoing research aimed to build the first corpus, 5 million words, for Mongolian language by focusing on annotating and tagging corpus texts according to TEI XML (McQueen, 2004) format. Also, a tool, MCBuilder, which provides support for flexibly and manually annotating and manipulating the corpu...
This paper presents a first attempt to develop Mongolian speech corpus that designed for data-driven speech synthesis in Mongolia. The aim of the speech corpus is to develop a high-quality Mongolian TTS for blinds to use with screen reader. The speech corpus contains nearly 6 hours of Mongolian phones. It well provides...
A New Class of Fast Nonlinear Voltage Controllers and their Impact on Improved Transmission Capacity
This work is motivated by the present needs to increase tranmission capacity of power systems operating far from conditions for which they were originally designed, without having to endanger their integrity when an unexpected fault occurs. Most of the theoretical work related to this problem has beenseparated into loa...
In order to provide more reliable state estimation addressing the problem of the bad data (BD) in the Phasor Measurement Unit (PMU)-based power systems synchronization, the paper focuses on developing a novel nonlinear estimation framework to track the voltage magnitude, phase angle, and frequency of the utility power ...
Thermodynamic Characteristics of Ethyl-2-cyano-3-(furan-2-yl)-prop-2-enoate Derivatives
Using bomb calorimetry and Knudsen effusion methods the enthalpic characteristics in condensed state of ethyl-2-cyano-3-(furan-2-yl) prop-2-enoate derivatives were experimentally determined. The values of the enthalpies of formation in the gas state of investigated esters were calculated taking into account the values ...
The Merck Index is a one-volume encyclopedia of chemicals, drugs and biologicals that contains more than 10,000 monographs. Each monograph in this authoritative reference source is a concise description of a single substance or a small group of closely related compounds. Compounds included: * human and veterinary drugs...
The role of magnesium on the structure of biological apatites
SummaryX-ray diffraction, infrared absorption spectroscopy, and chemical investigation have been carried out on deproteinated samples of turkey leg tendon at different degrees of calcification. The inorganic phase consists of poorly crystalline B carbonated apatite. On increasing calcification, the apatite crystal size...
X-ray diffraction, i.r. absorption, and chemical analyses have been carried out on the mineral deposits of calcified human mitral valves and glutaraldehyde-preserved porcine aortic grafts. The mineral deposits isolated from highly calcified mitral valves and porcine aortic grafts are constituted of type B-carbonate apa...
Hardness of approximating the undirected minimum size k-spanner
In the undirected unweighted minimum size k-spanner problem we are given a graph with edges of cost and length 1, and a number k. The goal is to find a minimum size E′ and a graph G′(V,E′) so that for every u, v ∈ V : distG(u, v) distG′(u, v) ≤ k. In [2], a conditional hardness was given to the problem, based on the co...
A set of vertices in a graph is a dominating set if every vertex outside the set has a neighbor in the set. The domatic number problem is that of partitioning the vertices of a graph into the maximum number of disjoint dominating sets. Let n denote the number of vertices, $\delta$ the minimum degree, and $\Delta$ the m...
Interpreting evidential distances by connecting them to partial orders: Application to belief function approximation
Distances between mass functions are instrumental tools in evidence theory, yet it is not always clear in which situation a particular distance should be used. Indeed, while the mathematical properties of distances have been well studied, how to interpret them is still a largely open issue. As a step towards answering ...
Abstract We prove that intersections and unions of independent random sets in finite spaces achieve a form of Lipschitz continuity. More precisely, given the distribution of a random set Ξ, the function mapping any random set distribution to the distribution of its intersection (under independence assumption) with Ξ is...
Impact of temporal aggregation on stock control performance of intermittent demand estimators: Empirical analysis
Intermittent demand is characterized by occasional demand arrivals interspersed by time intervals during which no demand occurs. These demand patterns pose considerable difficulties in terms of forecasting and stock control due to their compound nature, which implies variability both in terms of demand arrivals and dem...
Although intermittent demand items dominate service and repair parts inventories in many industries, research in forecasting such items has been limited. A critical research question is whether one should make point forecasts of the mean and variance of intermittent demand with a simple parametric method such as simple...
A Visual Model-Based Perceptual Image Hash for Content Authentication
Perceptual image hash has been widely investigated in an attempt to solve the problems of image content authentication and content-based image retrieval. In this paper, we combine statistical analysis methods and visual perception theory to develop a real perceptual image hash method for content authentication. To achi...
The block-based analysis for tamper localization is a prevailing mechanism in hash-based forgery detection algorithm. One of the main problems with a block-based analysis is its rough localization stemming from the demand to use relatively large blocks to reduce hash length. While decreasing the block size can improve ...
Diversity and classification of rheophilic communities of macrozoobenthos in middle latitudes of European Russia
Based on original data (450 samples from 115 streams of European Russian middle latitudes—from Pskov to Kostroma regions), an attempt is made to describe the diversity of rheophilic communities inhabiting stream bottoms and macrophytes. A total of 39 community types are identified by the Braun-Blanquet method. Their ta...
The fauna and diversity of macrozoobenthos communities in watercourses of the Khibiny tundras, the surrounding plains, and the Kandalaksha Coast of the White Sea (Murmansk oblast) are described from materials collected by the authors. A checklist of 110 recorded taxa is given, with larvae of Diptera, Trichoptera, Ephem...
Immunization with A91 peptide or copolymer‐1 reduces the production of nitric oxide and inducible nitric oxide synthase gene expression after spinal cord injury
Immunization with neurally derived peptides (INDP) boosts the action of an autoreactive immune response that has been shown to induce neuroprotection in several neurodegenerative diseases, especially after spinal cord (SC) injury. This strategy provides an environment that promotes neuronal survival and tissue preserva...
Glaucoma is a neurodegenerative disease with an estimated prevalence of 60 million people, and the most common cause of irreversible blindness worldwide. The mainstay of treatment has been aimed at lowering intraocular pressure, currently the only modifiable risk factor. Unfortunately, despite adequate pressure control...
Soliton fermionic number from the heat kernel expansion
We consider different methods of calculating the (fractional) fermion number of solitons based on the heat kernel expansion. We derive a formula for the localized $$\eta $$η function that provides a more systematic version of the derivative expansion for spectral asymmetry and compute the fermion number in a multi flav...
We study a fermion field coupled to a scalar via a Yukawa term. The scalar field is the $\phi^4$ model with an impurity that preserves half of the BPS property. We analyze the spectrum of the defects of the model and collisions between them both close to the BPS regime and not. As the fermion binds to these defects, it...
The Genericity Theorem and the Notion of Parametricity in the Polymorphic λ-calculus
This paper focuses on how terms of second order λ-calculus, which may take types as inputs, depend on types. These terms are generally understood to have an “essentially” constant meaning, in all models, on input types. We show how the proof theory of second order λ-calculus suggests a clear syntactic description of th...
Contemporary user interface development systems greatly simplify creation of traditional dialogueuser interface made of buttons or menus, but they do not support the construction and manipulation of application-specific graphical objects. This article describes Rollit, adomain-specific , interactive, application builde...
Sign language recognition using depth images
This paper presents a vision based sign language gesture recognition framework that can assist people with impaired hearing and speech with their social interaction and interactive communications. Utilizing a low-cost sensor, such as Microsoft Kinect combined with advanced machine learning analysis, it aims to ease the...
In this paper, we develop a vision-based system that employs a combined RGB and depth descriptor to classify hand gestures. The method is studied for a human-machine interface application in the car. Two interconnected modules are employed: one that detects a hand in the region of interaction and performs user classifi...
TelegraphCQ: An Architectural Status Report
We are building TelegraphCQ, a system to process continuous queries over data streams. Although we had implemented some parts of this technology in earlier Java-based prototypes, our experiences were not positive. As a result, we decided to use PostgreSQL, an open source RDBMS as a starting point for our new implementa...
Scientific experiments produce large volumes of data represented as complex objects that describe independent events such as particle collisions. Scientific analyses can be expressed as queries selecting objects that satisfy complex local conditions over properties of each object. The conditions include joins, aggregat...
Combined Geometric and Neural Network Approach to Generic Fault Diagnosis in Satellite Reaction Wheels
Abstract This paper suggests a novel diagnosis scheme for detection, isolation and estimation of faults affecting satellite reaction wheels. Both spin rate measurements and actuation torque defects are dealt with. The proposed system consists of a fault detection and isolation module composed by a bank of residual filt...
Abstract This paper presents a novel scheme for diagnosis of faults affecting the sensors measuring the satellite attitude, body angular velocity and flywheel spin rates as well as defects related to the control torques provided by satellite reaction wheels. A nonlinear geometric design is used to avoid that aerodynami...
Framework for Sentiment Analysis of Arabic Text
This paper analyses challenges, and provides a model and a framework for mining Arabic tweets to measure customer satisfaction toward telecom companies in Saudi Arabia, to predict the ratio of customer churn and overcome the specific challenges with the semantic sentiment analysis of Arabic text.
Twitter sentiment analysis offers organizations ability to monitor public feeling towards the products and events related to them in real time. The first step of the sentiment analysis is the text pre-processing of Twitter data. Most existing researches about Twitter sentiment analysis are focused on the extraction of ...
Central nervous system complications in human herpesvirus-6 infection
Human herpesvirus-6 (HHV-6) is the causative agent of the common childhood infectious disease, exanthem subitum. After the virus was recently isolated from humans, it was found to be closely related to human cytomegalovirus (CMV), and was thus classified within the beta subgroup of human herpesviruses. HHV-6 possesses ...
Alzheimer’s disease (AD) is the most common form of senile dementia and, due to the worldwide increase of life expectancy, has rapidly become a major medical issue in industrialized countries. The economical toll of AD on public health is enormous, and is estimated to hover actually around US $ 818 billion, representin...
Concerning the CYP 17 MSPA 1 polymorphism and breast cancer risk : a meta-analysis
Feigelson and colleagues have raised some important points concerning the selection of the data sets and the application of meta-analysis to resolve some of the problems associated with determining the relationships between metabolic polymorphisms and susceptibility to various disease conditions. In recent years, many ...
Inter-individual differences in susceptibility to breast cancer are partially mediated through the levels of endogenous and exogenous steroid hormones. The CYP17 gene encodes P450c17alpha, an enzyme that is involved in the metabolism of steroid hormones. Increased endogenous steroid hormone levels have been associated ...
Expression Patterns of Cancer-Testis Antigens in Human Embryonic Stem Cells and Their Cell Derivatives Indicate Lineage Tracks
Pluripotent stem cells can differentiate into various lineages but undergo genetic and epigenetic changes during long-term cultivation and, therefore, require regular monitoring. The expression patterns of cancer-testis antigens (CTAs) MAGE-A2, -A3, -A4, -A6, -A8, -B2, and GAGE were examined in undifferentiated human e...
BackgroundThe Cancer/Testis Antigens (CTAs) are a heterogeneous group of proteins whose expression is typically restricted to the testis. However, they are aberrantly expressed in most cancers that have been examined to date. Broadly speaking, the CTAs can be divided into two groups: the CTX antigens that are encoded b...
An Enhanced Boundary Scan Architecture for Inter-Die Interconnect Leakage Measurement in 2.5D and 3D Packages
3D-IC is a solution to achieve lower cost and higher performance as the transistor density doubles every 18 months following Moore's law. In recent years, Integrated Fan-Out Wafer-Level Chip-Scale Packaging (InFO WLCSP) is one of the most promising packaging technologies for 3D-IC. In InFO WLCSP, there are some inter-d...
To be “More than Moore's law”, Integrated Fan-Out Wafer-Level Chip-Scale Packaging (InFO WLCSP) is more cost-effective than other 3D-integrated-circuit (3DIC) technologies for consumer mobile, wearable, and “Internet-of-Things” (IoT) markets. To further improve the test quality, yield, and cost of InFO WLCSP by probing...
EcoRI-modified gold nanoparticles for dual-mode colorimetric detection of magnesium and pyrophosphate ions.
Magnesium in its ionic form (Mg 2 + ) is essential for many physiological processes, including much of metabolism, enzyme activation and catalysis, photosynthesis development, signal transduction, and protection against hypertension and blood vessel spasm. [ 1 ] Therefore, it has been long recognized that for suitable ...
DNA-functionalized nanoparticle (DfNP) technology, the integration of DNA with nanotechnology, has emerged over recent decades as a promising biofunctionalization tool in the light of biotechnological approaches. The development of DfNPs has exhibited significant potential for several biological and biomedical applicat...
Therapeutic efficacy of Ashwagandha against experimental aspergillosis in mice.
Therapeutic efficacy of an Indian Ayurvedic medicinal preparation, Ashwagandha [Withania somnifera L. Dunal (Solanceae; root)] was evaluated against experimental aspergillosis in Balb/c mice. Ashwagandha given orally once daily for 7 consecutive days in a dose of 100 mg/kg after intravenous infection of Aspergillus fum...
SUMMARY The use of and search for drugs and dietary supplements derived from plants have accelerated in recent years. Ethnopharmacologists, botanists, microbiologists, and natural-products chemists are combing the Earth for phytochemicals and “leads” which could be developed for treatment of infectious diseases. While ...
Direct observation of electronic-liquid-crystal phase transitions and their microscopic origin in La1/3Ca2/3MnO3
The ground-state electronic order in doped manganites is frequently associated with a lattice modulation, contributing to their many interesting properties. However, measuring the thermal evolution of the lattice superstructure with reciprocal-space probes alone can lead to ambiguous results with competing interpretati...
Collective dynamics often play an important role in determining the stability of ground states for both naturally occurring materials and metamaterials. We studied the temperature dependent dynamics of antiferromagnetically ordered superdomains in a square artificial spin lattice using soft x-ray photon correlation spe...
When are metal ion-dependent hydroxyl and alkoxyl radical adducts of 5,5-dimethyl-1-pyrroline N-oxide artifacts?
The formation of the 5,5-dimethyl-1-pyrroline N-oxide (DMPO)/.OH adduct of the spin trap DMPO has been reported to occur through nucleophilic addition of water in the presence of aqueous ferric chloride (K. Makino, T. Hagiwara, A. Hagi, M. Nishi, and A. Murakami, 1990, Biochem. Biophys. Res. Commun. 172, 1073-1080). Du...
2-Hydroxy-5,5-dimethyl-1-pyrrolidinyloxy (DMPO-OH), which is known to be produced by spin trapping of hydroxyl radicals (.OH) with 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and has been a good monitor for detecting .OH in biological systems, has been examined by EPR for its production scheme in the presence of iron ion. ...
Large-Scale Interdisciplinary Design Thinking for Dealing with Twenty-First Century Problems and Opportunities
This analysis extends creative design thinking to the macro-level, applying it to the enormous problems and opportunities generated by twenty-first century globalization. Today’s macroproblems and macro-opportunities require creative, interdisciplinary thinking, and collaboration to enable individuals and teams to addr...
In recent decades, empathy research has blossomed into a vibrant and multidisciplinary field of study. The social neuroscience approach to the subject is premised on the idea that studying empathy at multiple levels (biological, cognitive, and social) will lead to a more comprehensive understanding of how other people'...
Grouped L0 least squares penalised Magnetoencephalography
The distributed source inverse problem for Magnetoencephalography (MEG) requires regularisation in order to calculate a stable and accurate solution. Recently there has been interest in source reconstruction via the l1 penalised least squares problem. Although this gives some sparseness the ideal measure for sparsity i...
This paper addresses the problem of identifying the topology of a sparsely connected network of dynamic systems. The goal is to identify the links, the direction of information flow and the transfer function of each dynamic system. The output of each system is affected by the incoming data of the directly connected sys...
Biodegradable Chitosan-Based Ambroxol Hydrochloride Microspheres: Effect of Cross-Linking Agents
The objective of this study was to investigate the influence of type of cross-linking method used on the properties of ambroxol hydrochloride microspheres such as encapsulation efficiency, particle size, and drug release. Microspheres were prepared by solvent evaporation technique using chitosan as a matrix-forming age...
The aim of the study was to compare the gelation and drug release characteristics of formulations of pectin with high (31%) and low (9%) degrees of methoxylation over a wide pH range (pH 1.2-5.0). Dilute solutions of pectin (1.5%, w/v) containing complexed calcium ions formed gels in vitro at low pH (pH<2.5) as a conse...
The nature of visual self-recognition revisited
It is not true that mirror self-recognition has nothing to do with self-awareness and, contrary to Suddendorf and Butler's claim [1], that self-recognition is ‘universally acquired in toddlers’, there are failures to find mirror self-recognition in mentally retarded children, adolescents, and adults, as well as in auti...
At its most basic level, the sense of self is built upon awareness of one's body and the face holds special significance as the individual's most important and distinctive physical feature. Multimodal sensory integration is pivotal to experiencing one's own body as a coherent visual “self” representation is formed and ...
Handling dynamic schema change in process models
Workflow technology has emerged as an appropriate platform for consolidating the distributed information resources of an enterprise, promoting interoperability across cross-platform systems and for providing a global view and understanding of business process models. However, the business processes that workflows repre...
The advantages of today'sprocess management, such as efficiency and quality aspects, are achievedby enforcing detailed models of work processes. But real world processescan be planned only to a limited degree and sometimes demand changing alreadyplanned parts of the process. So additional, unforeseen activities haveto ...
Limitations of European Union policy and law for regulating use of lead shot and sinkers: comparisons with North American regulation
Extensive shooting and angling causes, indirectly, fatal lead poisoning of birds. European Union policy on this major source of pollution is inconsistent with its laws regulating other forms of lead in the environment. Only three countries have banned the use of lead shot completely in the European Union, despite avail...
Each year, 1.2 million Spanish hunters and shooters discharge 6,000 t of lead shot, of which 30-50 t are deposited in wetlands of this European country. Waterfowl may accidentally ingest lead pellets in these aquatic habitats and become fatally lead poisoned. It has been estimated that 50,000 birds die from this cause ...
The Development Process and Design of a Hybrid Fuzzy Knowledge-Based System for Multiobjective Optimization of Power Distribution System Operations
A hybrid fuzzy knowledge-based system with crisp and fuzzy rules as well as numerical methods was developed for multiobjective optimization of power distribution system operations. The development process and knowledge acquisition process for the fuzzy knowledge-based system are described in detail. The fuzzy knowledge...
A knowledge-based system is defined that ensures network radiality during reconfiguration of a power distribution system. Network radiality heuristics identify a pair of switching operations that preserves radiality. A matrix-structured knowledge base with five distinct rule bases is used. Rule base A is used in determ...
Water anomalous thermodynamics, attraction, repulsion, and hydrophobic hydration.
A model composed of van der Waals-like and hydrogen bonding contributions that simulates the low-temperature anomalous thermodynamics of pure water while exhibiting a second, liquid-liquid critical point [P. H. Poole et al., Phys. Rev. Lett. 73, 1632 (1994)] is extended to dilute solutions of nonionic species. Critical...
Osmotic second virial coefficients in dilute aqueous solutions of small nonpolar solutes are calculated from three different two-component equations of state. The solutes are five noble gases, four diatomics, and six hydrocarbons in the range C1-C4. The equations of state are modified versions of the van der Waals, Red...
The point spread function of the human head and its implications for transcranial current stimulation
Rational development of transcranial current stimulation (tCS) requires solving the ‘forward problem’: the computation of the electric field distribution in the head resulting from the application of scalp currents. Derivation of forward models has represented a major effort in brain stimulation research, with model co...
Research in the area of transcranial electrical stimulation (TES) often relies on computational models of current flow in the brain. Models are built on magnetic resonance images (MRI) of the human head to capture detailed individual anatomy. To simulate current flow, MRIs have to be segmented, virtual electrodes have ...
The Effect of Pterygomasseteric Sling's Area in the Postoperative Stability after Mandibular Setback Surgery
Purpose The purpose of the present study was to investigate the correlation between the postoperative stability and area of pterygomasseteric sling (PMS). Materials and Methods Forty patients of mandibular prognathism were treated by isolated mandibular setback. Serial lateral cephalograms were collected (preoperativel...
OBJECTIVE To evaluate the long-term changes of masseter muscle morphology in skeletal Class III patients with facial asymmetry following two-jaw orthognathic surgery (Le Fort I osteotomy + intraoral vertical ramus osteotomy). MATERIALS AND METHODS Using computed tomography (CT), a longitudinal study was conducted on ...
An improvement of the Hasse-Weil-Serre bound for curves over some finite fields
The Hasse-Weil-Serre bound is improved for low genus curves over finite fields with discriminant from {-3,-4,-7,-8} by studying maximal and minimal curves.
We show that for all finite fields Fq, there exists a curve C over Fq of genus 3 such that the number of rational points on C is within 3 of the Serre–Weil upper or lower bound. For some q, we also obtain improvements on the upper bound for the number of rational points on a genus 3 curve over Fq.
Formalizing Dynamic Software Updating
Dynamic software updating (DSU) enables running programs to be updated with new code and data without interrupting their execution. A number of DSU systems have been designed, but there is still little rigorous understanding of how to use DSU technology so that updates are safe. As a first step in this direction, we in...
Using plugins as a mechanism for extending applications to provide extra functionality is appealing, but current implementations are limited in scope. We have designed a framework to allow the construction of flexible and complex systems from plugin components. In this paper we describe how the use of modelling techniq...
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.
Although the outcome of therapy for leukemia has improved over the years, mainly in younger patients, less than a third of adults with acute myeloid leukemia (AML), for example, are cured by current treatments, a fact stressing the need for new therapeutic approaches. Since leukemias are considered disorders of self-re...
UNLABELLED Recent technological advances in nanomedicine and nanotechnology in parallel with knowledge accumulated from the clinical translation of disease- and drug-related genomic data have created fertile ground for personalized medicine to emerge as the new direction in diagnosis and drug therapy. To this end, the ...
Prospective Monitoring Reveals Dynamic Levels of T Cell Immunity to Mycobacterium Tuberculosis in HIV Infected Individuals
Monitoring of latent Mycobacterium tuberculosis infection may prevent disease. We tested an ESAT-6 and CFP-10-specific IFN-γ Elispot assay (RD1-Elispot) on 163 HIV-infected individuals living in a TB-endemic setting. An RD1-Elispot was performed every 3 months for a period of 3–21 months. 62% of RD1-Elispot negative in...
SETTING South African gold mines. OBJECTIVE To determine the prevalence of latent tuberculosis infection (LTBI) and risk factors for a positive tuberculin skin test (TST) among gold miners. DESIGN Cross-sectional survey. Human immunodeficiency virus (HIV) status was determined by self-report and medical records. TS...
Prospective Evaluation of Allograft Meniscus Transplantation
Background Clinical and biomechanical studies have demonstrated the increase in contact pressure and progressive deterioration of the tibiofemoral compartments that occur after partial or complete meniscectomy. Meniscus transplantation has been indicated for the symptomatic postmeniscectomy patient to alleviate symptom...
Background: Meniscal allograft transplantation is a viable option for subtotally meniscectomized and totally meniscectomized symptomatic patients and potentially results in pain relief and increased function. Hypothesis: The use of a single tibial tunnel arthroscopic technique without bone plugs will reduce symptoms (p...
Neural network solution for an inverse problem associated with the Dirichlet eigenvalues of the anisotropic Laplace operator
An innovative numerical method based on an artificial neural network is presented in order to solve an inverse problem associated with the calculation of the Dirichlet eigenvalues of the anisotropic Laplace operator. Using a set of predefined eigenvalues obtained by solving repeatedly the direct problem, a radial basis...
It has been found recently that the multiple reciprocity method (MRM) (Chen and Wong. Engng. Anal. Boundary Elements 1997; 20(1):25–33; Chen. Processings of the Fourth World Congress on Computational Mechanics, Onate E, Idelsohn SR (eds). Argentina, 1998; 106; Chen and Wong. J. Sound Vibration 1998; 217(1): 75–95.) or ...
The association between psychosocial stress and mortality is mediated by lifestyle and chronic diseases: the Hoorn Study.
Psychosocial stress is associated with chronic disease. We evaluated whether in the general population the number of stressful life events is associated with risk of mortality and whether this association is mediated by behavioral factors and morbidities. We conducted this study in the Hoorn cohort; a population-based ...
Cardiovascular survey methods , Cardiovascular survey methods , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Probe, count, and classify: categorizing hidden web databases
The contents of many valuable web-accessible databases are only accessible through search interfaces and are hence invisible to traditional web “crawlers.” Recent studies have estimated the size of this “hidden web” to be 500 billion pages, while the size of the “crawlable” web is only an estimated two billion pages. R...
When a query is submitted to a search engine, the search engine returns a dynamically generated result page that contains the number of hits (i.e., the number of matching results) for the query. Hit number is a very useful piece of information in many important applications such as obtaining document frequencies of ter...
Standing sway: iterative estimation of the kinematics and dynamics of the lower extremities from force-plate measurements
Abstract In this study, a model for the estimation of the dynamics of the lower extremities in standing sway from force plate data only is presented. A three-dimensional, five-segment, four-joint model of the human body was used to describe postural standing sway dynamics. Force-plate data of the reactive forces and ce...
Control of standing requires the continuous activity of the leg muscles. In single leg standing the system is less redundant and muscular activity is more intensive. The objective of this study was to examine the effect of force imbalance of the shank muscles, evoked by their selective fatiguing, on postural control in...
Comparison of Three Alleles at a Major Solid Stem QTL for Wheat Stem Sawfly Resistance and Agronomic Performance in Hexaploid Wheat
Solid stems provide resistance to the wheat stem sawfly (WSS, Cephus cinctus Nort.) in wheat (Triticum aestivum L.). A major quantitative trait locus, designated Qss.msub-3BL, controls most of the variation for stem solidness. Two alleles that differ for temporal expression of stem solidness have been identified. An al...
Abstract Wheat stem sawfly, Cephus cinctus Norton, is an economically serious pest of cereals grown in North America. Barley cultivars were previously planted as resistant crops in rotations to manage C. cinctus, but due to increasing levels of injury to this crop, this is no longer a valid management tactic in Montana...
Some Refinements of the Orthodox Theory
Explicitly or implicitly, all the theoretical models examined so far, have a common set of assumptions: perfect competition, the rigid supply of productive factors, absence of intermediate goods, absence of transport costs, certainty, absence of illegal trade (such as smuggling), and so on. These are undoubtedly assump...
This paper addresses the relation between goods trade and international factor mobility in general terms. Conditions for factor price equalization are derived for situations with tradein both goods and factors,as well as Rybczynski and Stolper-Sarnuel Sofl theorems. A weak price versionof the Heckscher-Ohlifl theorem i...
Controlling Risk in Defense Acquisition Programs: The Evolving Decision Review Framework
In the last three years, there has been a great deal of turbulence in U.S. defense acquisition policy. This has contributed to confusion within the acquisition workforce in terminology, major policy thrusts, and unclear implications of the changes. The new acquisition framework has added complexity, with more phases an...
Preface Part I. An Overview Introduction Part II. Some Images of Organization 2. Mechanization Takes Command: Organizations as Machines Machines, Mechanical Thinking, and the Rise of Bureaucratic Organization The Origins of Mechanistic Organization Classical Management Theory: Designing bureaucratic organizations Scien...
Optimum pressure in low temperature direct metal bonding
The influence of bonding pressure during low temperature direct metal bond formation between gold studs and electroplated copper joints respectively was evaluated. The findings obtained showed an optimum pressure where bond strength peaks before degrading at further increase in bond pressure. Furthermore, it was found ...
This article discusses thermo-compression bonding (also known as diffusion bonding) of metallic copper and its application in 3-D stacking of ICs. Bonding process is described and characterization results are presented. A survey on recent progress of copper-based wafer bonding, particularly low temperature process, and...
Granularity of the diffuse background observed
Abstract First results are reported from a program for measuring the field-to-field fluctuation level of the cosmic diffuse background by using differences between the two background positions of each deep exposure with the HEXTE instrument on RXTE. With 8 million live seconds accumulated to date a fluctuation level on...
We show that Compton scattering by electrons of the hot intergalactic gas in galaxy clusters should lead to peculiar distortions of the cosmic background X-ray and soft gamma-ray radiation - an increase in its brightness at E 1, the effect allows one to determine how the X-ray background evolved and how it was "gathere...
Management of renal caliceal diverticular stones: A decade of experience
Objective: The objective of this study is to evaluate our methods for management of renal caliceal diverticular stones (CDS). Materials and Methods: We conducted a retrospective study from January 2005 to July 2015 and included patients who were treated for renal CDS. Patients were evaluated for treatment modality, pun...
Introduction. Calyx diverticulum is a rather rare pathology in pediatric practice. In the structure of cystic kidney malformations, it amounts up to 12-15%. In most cases, the disease is asymptomatic. To make a differential diagnostics and to define a technique for surgical treatment, computed tomography or magnetic re...
Ontology Evolution: State of the Art and Future Directions
Ontologies evolve continuously throughout their lifecycle to respond to different change requirements. Several problems emanate from ontology evolution: capturing change requirements, change representation, change impact analysis and resolution, change validation, change traceability, change propagation to dependant ar...
A suite of metrics is proposed to assess the quality of an ontology. Drawing upon semiotic theory, the metrics assess the syntactic, semantic, pragmatic, and social aspects of ontology quality. We operationalize the metrics and implement them in a prototype tool called the Ontology Auditor. An initial validation of the...
Kaurenoic Acid from Pulp of Annona cherimolia in regard to Annonaceae‐induced Parkinsonism
Guadeloupean Parkinsonism has been linked epidemiologically to the consumption of Annonaceae fruits. These were proposed to be etiological agents for sporadic atypical Parkinsonism worldwide, because of their content of neurotoxins such as isoquinolinic alkaloids and Annonaceous acetogenins. The pulp of Annona cherimol...
The consumption of medicinal plants has notably increased over the past two decades. People consider herbal products as safe because of their natural origin, without taking into consideration whether these plants contain a toxic principle. This represents a serious health problem. A bibliographic search was carried out...
Influence of aluminum phosphate contaminant on discharge characteristics of suspension glass insulators
Contaminant composition affects the discharge characteristics of external insulation. This paper studies the intense discharge phenomenon at low relative humidity (77%) in an AC 500 kV substation in Southern China. Due to farming and the soil feature in the sugar cane field around the substation, aluminum phosphate is ...
This paper attempts to address the influence of sugar as a contaminant on outdoor insulation characteristics of insulators in a substation. Strong discharge activity was occurred under relative humidity less than 80% on insulators in a 500 kV substation at south China. A preliminary viewpoint that sugar as a contaminan...
Hereditary motor and sensory neuropathy--Lom, a novel demyelinating neuropathy associated with deafness in gypsies. Clinical, electrophysiological and nerve biopsy findings.
A previously unrecognized neuropathy was identified in Bulgarian gypsies, and was designated hereditary motor and sensory neuropathy-Lom (HMSNL) after the town where the initial cases were found. It was subsequently identified in other gypsy communities. The disorder, which is of autosomal recessive inheritance, was ma...
Founder effect and linkage disequilibrium have been successfully exploited to map single gene disorders1, and the study of isolated populations is emerging as a major approach to the investigation of genetically complex diseases2. In the search for genetic isolates ranging from Pacific islands to Middle East deserts, t...
Correlation between extraordinary optical transmission and polarization in metallic subwavelength structures
Extraordinary optical transmission (EOT) of both transverse-electric (TE) and transverse-magnetic (TM) polarizations was investigated for sub-wavelength metallic structures by the rigorous coupled-wave analysis, implemented as the Airy-like internal reflection series. Generally, because of the absence of coupled surfac...
A review and analysis is performed of various resonance effects associated with subwavelength one-dimensional (1-D) metal gratings for transverse electric (TE) and transverse magnetic (TM) polarized incident radiation. It is shown that by tuning the structural geometry (especially the groove width) and material composi...
HIV pre-exposure prophylaxis for people who inject drugs: a review of current results and an agenda for future research
Studies examining the use of pre‐exposure prophylaxis (PrEP) to prevent HIV transmission among people who inject drugs (PWIDs) have not been adequately summarized. Recently, the Bangkok Tenofovir Study has shown that PrEP may be effective at reducing new HIV infections among this high‐risk group. This randomized contro...
BACKGROUND Recent trials report the short-term efficacy of tenofovir-based pre-exposure prophylaxis (PrEP) for prevention of human immunodeficiency virus (HIV) infection. PrEP's long-term impact on patient outcomes, population-level transmission, and cost-effectiveness remains unknown. METHODS We linked data from rec...
A novel protocol to provide a suitable cardiac model from induced pluripotent stem cells.
Cumulative evidence has proven the safety, feasibility and efficacy of stem cell therapy for cardiomyocyte replacement in heart failure treatment. In contrast to embryonic stem cells, induced pluripotent stem cells (iPS cells) provide a route to the production of patient-specific stem cell lines with no ethical concern...
IntroductionMolecular imaging strives to visualise processes at the molecular and cellular level in vivo. Understanding these processes supports diagnosis and evaluation of therapeutic efficacy on an individual basis and thereby makes personalised medicine possible.Apoptosis and molecular imagingApoptosis is a well-org...
Improved Model Generation of AMS Circuits for Formal Verification
Recently, formal verification has had success in rigorously checking the correctness of digital designs. We have developed the LEMA tool to provide a methodology for the formal verification of analog/mixed-signal (AMS) circuits. In particular, LEMA utilizes a labeled Petri net (LPN) model to represent AMS circuit behav...
This paper presents two symbolic model checking algorithms for the verification of analog/mixed-signal circuits. The first model checker utilizes binary decision diagrams while the second is a bounded model checker that uses a satisfiability modulo theory solver. Both methods have been implemented, and preliminary resu...
Comparison of Neoadjuvant vs Concurrent/Adjuvant Androgen Deprivation in Men with High-risk Prostate Cancer Receiving Definitive Radiation Therapy
Purpose It is unknown whether there is a benefit to starting androgen deprivation therapy (ADT) prior to rather than concurrently with definitive radiation therapy in men with high-risk prostate cancer. We studied the National Cancer Data Base to determine whether the timing of ADT impacts survival. Methods Men diagnos...
BACKGROUND The aim of this trial was to compare dose-escalated conformal radiotherapy with control-dose conformal radiotherapy in patients with localised prostate cancer. Preliminary findings reported after 5 years of follow-up showed that escalated-dose conformal radiotherapy improved biochemical progression-free surv...
Spin-Torque Switching with the Giant Spin Hall Effect of Tantalum
Giant Spin Hall One of the primary challenges in the field of spin-electronics, which exploits the electron's spin rather than its charge, is to create strong currents of electrons with polarized spins. One way to do this is to use a ferromagnet as a polarizer, a principle used in magnetic tunnel junctions; however, th...
Brain-inspired computing architectures attempt to mimic the computations performed in the neurons and the synapses in the human brain in order to achieve its efficiency in learning and cognitive tasks. In this work, we demonstrate the mapping of the probabilistic spiking nature of pyramidal neurons in the cortex to the...
Performance analysis of MIMO-IDMA system using spatial diversity in frequency-selective channel
In this letter, we investigate the bit-error rate (BER) performance of uncoded space-time transmit diversity (STTD) aided interleave division multiple access (IDMA) scheme for down-link (DL) communications. In this contribution, we consider the orthogonal structure based on Alamouti Space-Time code which offers full ra...
In this correspondence, we investigate and study the performance of multi-user transmitter preprocessing (MUTP) aided multi-carrier interleave division multiple access (MC-IDMA) systems in frequency-selective channels under perfect and imperfect channel state information (CSI) at the transmitter. The MUTP considered in...
Provenance Data in Social Media
Social media shatters the barrier to communicate anytime anywhere for people of all walks of life. The publicly available, virtually free information in social media poses a new challenge to consumers who have to discern whether a piece of information published in social media is reliable. For example, it can be diffic...
The results of the 2016 Brexit referendum in the U.K. and presidential election in the U.S. surprised pollsters and traditional media alike, and social media is now being blamed in part for creating echo chambers that encouraged the spread of fake news that influenced voters.
Simple Wait-Free Snapshots for Real-Time Systems with Sporadic Tasks
We present a simple and wait-free implementation of a snapshot shared data structure suitable for real-time systems with sporadic tasks. Snapshot mechanisms give the means to a real-time task to read a globally consistent set of variable values while other concurrent tasks are updating them. Such a mechanism can be use...
We present 2V-DBP-SNAP, an algorithm that allows hard real-time tasks in an embedded real-time control system to read a snapshot of a number of data elements in a real-time database. Furthermore, 2V-DBP-SNAP allows these data elements to be shared with soft real-time tasks, which access them using a database query lang...
Geographic Routing Using Logical Levels in Wireless Sensor Networks for Sensor Mobility
In this paper we propose an improvement to the GRPW algorithm for wireless sensor networks called GRPW-M , which collects data in a wireless sensor network (WSN) using a mobile nodes. Performance of GRPW algorithm algorithm depends heavily on the immobile sensor nodes . This prediction can be hard to do. For that reaso...
This paper presents a novel convergecast algorithm called, Virtual Circle Combined Straight Routing (VCCSR), which collects data in a wireless sensor network (WSN) using a mobile sink. Tree-based routing offers the shortest routes to deliver data, and it is a common scheme used by mobile sinks to collect data from sens...
A conditional estimating equation approach for recurrent event data with additional longitudinal information
Recurrent event data are quite common in biomedical and epidemiological studies. A significant portion of these data also contain additional longitudinal information on surrogate markers. Previous studies have shown that popular methods using a Cox model with longitudinal outcomes as time‐dependent covariates may lead ...
: In this work, we study the event occurrences of individuals interacting in a network. To characterize the dynamic interactions among the individuals, we propose a group network Hawkes process (GNHP) model whose network structure is observed and fixed. In particular, we introduce a latent group structure among individ...
Persistence of HPV after radio-chemotherapy in locally advanced cervical cancer.
A causal association of high risk HPV persistent infections with cervical cancer is firmly established by epidemiological and experimental evidence. Since HPV is considered a necessary factor for cervix carcinoma development and disease severity, the HPV DNA persistence may represent an indicator of both therapy effect...
OBJECTIVE The aims of this study were (1) to examine whether HPV DNA is persistently detected in the cervix after therapeutic conization for CIN 3 and (2) to explore whether a patient with persistence of HPV infection is at risk of developing recurrent disease. METHODS Of 74 patients referred with CIN 3, 58 who were ...
RNA Interference Targets Arbovirus Replication in Culicoides Cells
ABSTRACT Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks, and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms. RNA interference (RNAi) is a sequence-specific RNA degradation ...
Summary: RNA interference (RNAi) is known to play an important part in defence against viruses in a range of species. Second-generation sequencing technologies allow us to assay these systems and the small RNAs that play a key role with unprecedented depth. However, scientists need access to tools that can condense, an...
Synthesis and structure of a layered titanosilicate catalyst with five-coordinate titanium
TITANIUM occurs widely in the Earth's crust, traces of it being present in most rocks, soils and clays. It is estimated that titanosilicate minerals alone number more than 100; but, remarkably, in only one of these does the Ti(IV) ion take up fivefold coordination. This is in fresnoite1 (Ba2TiSi2O8), which contains squ...
Dibarium dititanium difluoride dioxide heptaoxidodisilicate, Ba(2)Ti(2)Si(2)O(9)F(2), is a new edge-sharing titanate with a unique titanium silicate framework. All atoms in the structure are in general positions. Titanium oxyfluoride octahedra combine with silicon tetrahedra to form a double stacked chain, which is the...
Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.
Despite extensive studies, there are still many unanswered questions regarding the mechanism of hedgehog signaling and the phylogenic conservation of hedgehog function in vertebrates. For example, whether hedgehog signaling in vertebrates requires smoothened is unclear, and the role of hedgehog activity in zebrafish is...
Zebrafish you-too (yot) mutations interfere with Hedgehog (Hh) signaling during embryogenesis. Using a comparative synteny approach, we isolated yot as a zinc finger transcription factor homologous to the Hh target gli2. Two alleles of yot contain nonsense mutations resulting in carboxy-terminally truncated proteins. I...
Not all new recombinant human erythropoietins are biosimilars.
To the Editor: We completely agree with the critical point of view expressed by Dr Singh regarding the new challenges raised by epoetin-a’s copies known as follow-on epoetin. However, we would like to stress the point that the qualification of Wepox (Wockhardt Limited, Mumbai, India) as a ‘biosimilar’ is probably not f...
The first generation of biopharmaceuticals has begun to lose patent protection. Richard Frank writes that there is concern that without new U.S. regulations, patent expirations may not be accompanied by the introduction of competing, lower-cost biologic agents, or that imitator products might be approved without suffic...
Parametric conversion with distributedly modulated capacitors (DMC) for low-noise and non-reciprocal RF front-ends
Transmission lines with time-varying reactance exhibit interesting behaviors such as parametric amplification and mixing [1]. In this paper, such a transmission line realized with distributedly modulated capacitors (DMC) is demonstrated with its active conversion gain, low noise figure as well as non-reciprocity. DMC i...
The concept of distributedly modulated capacitors (DMC) is proposed as a form of time-varying transmission-line structure offering nonreciprocal propagation and coupling characteristics. The nonreciprocity is achieved by taking advantage of the additional dimension of time-variance in the transmission-line property. Th...
Nanoparticle-coated PDMS elastomers for enhancement of Raman scattering.
A simple but efficient method for highly sensitive Raman detection, covering a thin polydimethylsiloxane elastomer, pre-coated with a layer of Au or Ag nanoparticles, onto the detected substrate, is proposed. Moreover, this nanoparticle-coated PDMS elastomer can be used for chemical imaging with high sensitivity.
Self-assembled monolayers (SAMs) form when organic molecules spontaneously chemisorb on the surfaces of solids (e.g. organic thiols and disulfides on gold, silver, and copper or carboxylic acids on the surface of alumina).1'2 The most robust and best characterized SAMs are those comprising alkanethiolates on gold.l By ...
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