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subject stringlengths 63 104	txt_report stringlengths 1.18k 4.14k	gold_diagnosis stringclasses 5 values	cognitive_txt stringlengths 378 3.64k
FTLD_203454401_03105_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10178120	On a T1-weighted brain MRI we observed: For the cerebral cortex: - mild-to-moderate atrophy of the right limbic cortex; normal-to-mild atrophy of the left limbic cortex; focal volume loss observed in the following subregions: parahippocampal gyrus (mild-to-moderate atrophy both left and right), entorhinal area (mild atrophy both left and right) and middle cingulate gyrus (mild atrophy on the right) - mild atrophy of the left parietal lobe; the right parietal lobe is normal; focal volume loss observed in the following subregions: supramarginal gyrus (mild atrophy on the left) - occipital lobe demonstrates a healthy morphology without signs of atrophy - mild atrophy of the right insular cortex; the left insular cortex is normal; focal volume loss observed in the following subregions: posterior insula (normal on the left and mild atrophy on the right) and parietal operculum (normal on the left and mild atrophy on the right) - frontal lobe appears within normal limits without apparent atrophy - moderate atrophy of the right temporal lobe; normal-to-mild atrophy of the left temporal lobe; focal volume loss observed in the following subregions: temporal pole (mild atrophy on the left and moderate atrophy on the right), middle temporal gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), inf. temporal gyrus (normal on the left and mild atrophy on the right) and fusiform gyrus (mild atrophy on the right) For the subcortical structures: - mild bilateral atrophy of the putamen - mild atrophy of the right pallidum; the left pallidum is normal - thalamus appears within normal limits without apparent atrophy - mild atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus - mild-to-moderate atrophy of the right accumbens; normal-to-mild atrophy of the left accumbens - mild atrophy of the right caudate; the left caudate is normal - moderate atrophy of the left amygdala and severe atrophy of the right amygdala For the ventricles: - mild enlargement of the external csf - moderate enlargement of the left inf. lateral ventricle and severe enlargement of the right inf. lateral ventricle - mild-to-moderate enlargement of the 3rd ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - mild-to-moderate enlargement of the left lateral ventricle and moderate enlargement of the right lateral ventricle	BV	We have the following subject's personal information: - The subject is a male of 72.0 years old. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 14. - On the semantic categorical fluency test, the subject named 9 animals in 60 seconds. He named 2 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 9. - On the Number Span forward test, his longest span forward was 9. On the Number Span backward test, his longest span backward was 8. - On the Trail Making Test Part A, his total number of seconds to complete is 59, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 97, his number of commission errors is 0, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in delusions, agitation or aggression, a moderate (significant, but not dramatic) change in apathy or indifference, a mild (noticeable, but not significant) change in anxiety, irritability or lability. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 3.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 0.5 (questionnable impairment). Description: Consistent mild word-finding difficulties; simplification of word choice; circumlocution; decreased phrase length; and/or mild comprehension difficulties.
ADNI_123_S_10648_MR_Accelerated_Sagittal_MPRAGE_MSV21_br_raw_20250408190751699_1_I11185466	On a T1-weighted brain MRI we observed: For the cerebral cortex: - insular cortex appears preserved, with no observable tissue loss - frontal lobe maintains a normal appearance with no observable atrophic features - occipital lobe appears within normal limits without apparent atrophy - limbic cortex appears within normal limits without apparent atrophy - the parietal lobe shows no notable changes suggestive of atrophy - mild atrophy of the right temporal lobe; the left temporal lobe is normal; focal volume loss observed in the following subregions: middle temporal gyrus (mild atrophy on the right) For the subcortical structures: - no appreciable degenerative or atrophic changes observed in the amygdala - thalamus demonstrates a healthy morphology without signs of atrophy - no clear atrophic alterations are visible in the caudate - pallidum maintains a normal appearance with no observable atrophic features - no findings suggestive of atrophy are seen in the accumbens - hippocampus appears preserved, with no observable tissue loss - no observable atrophic changes in the putamen For the ventricles: - external csf appears to be of normal dimensions, with no observable increase in size - no findings suggestive of enlargement are seen in the inf. lateral ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - 3rd ventricle maintains its expected proportions without signs of enlargement - no observable enlargement of the lateral ventricle	CN	We have the following subject's personal information: - The subject is a female of 65.2 years old. - Subject's current marrietal status is: married. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following subject's family history information: - Her mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 4. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 12. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e2 with no e4 allele.
ADNI_007_S_1304_MR_MPR__GradWarp__B1_Correction__N3__Scaled_Br_20070713111105724_S26475_I59910	On a T1-weighted brain MRI we observed: For the ventricles: - moderate enlargement of the left inf. lateral ventricle and mild enlargement of the right inf. lateral ventricle - mild-to-moderate enlargement of the 3rd ventricle - mild enlargement of the 4th ventricle - external csf maintains its expected proportions without signs of enlargement - mild enlargement of the left lateral ventricle; normal-to-mild enlargement of the right lateral ventricle For the subcortical structures: - pallidum maintains a normal appearance with no observable atrophic features - caudate appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the putamen - no observable atrophic changes in the accumbens - mild-to-moderate atrophy of the left hippocampus, mild atrophy of the right hippocampus - mild atrophy of the left amygdala; the right amygdala is normal - thalamus appears within normal limits without apparent atrophy For the cerebral cortex: - the frontal lobe shows no notable changes suggestive of atrophy - the parietal lobe shows no notable changes suggestive of atrophy - the limbic cortex shows no notable changes suggestive of atrophy - mild bilateral atrophy of the occipital lobe; focal volume loss observed in the following subregions: calcarine cortex (mild atrophy on the left and mild-to-moderate atrophy on the right), sup. occipital gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) and occipital pole (normal on the left and mild atrophy on the right) - no evident atrophy or tissue thinning seen in the temporal lobe - insular cortex maintains a normal appearance with no observable atrophic features	AD	We have the following subject's personal information: - The subject is a female of 74.8 years old. - Subject's current marrietal status is: married. - She has 8.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 25. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 0. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
NIFD_1_S_0053_MR_T1_mprage_S3_DIS3D_br_raw_20170817095339381_67_S597254_I890544	On a T1-weighted brain MRI we observed: For the subcortical structures: - the thalamus shows no notable changes suggestive of atrophy - no observable atrophic changes in the pallidum - moderate bilateral atrophy of the accumbens - mild bilateral atrophy of the putamen - mild-to-moderate atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus - moderate-to-severe bilateral atrophy of the amygdala - caudate maintains a normal appearance with no observable atrophic features For the cerebral cortex: - moderate bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: temporal pole (mild-to-moderate atrophy both left and right), fusiform gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right) and inf. temporal gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right) - the occipital lobe shows no notable changes suggestive of atrophy - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild atrophy both left and right) and entorhinal area (normal-to-mild atrophy on the left and mild atrophy on the right) - no appreciable degenerative or atrophic changes observed in the parietal lobe - frontal lobe maintains a normal appearance with no observable atrophic features - mild-to-moderate atrophy of the left insular cortex and moderate atrophy of the right insular cortex; focal volume loss observed in the following subregions: anterior insula (mild-to-moderate atrophy on the left and moderate atrophy on the right), posterior insula (mild atrophy on the left and mild-to-moderate atrophy on the right) and parietal operculum (normal-to-mild atrophy on the left and mild atrophy on the right) For the ventricles: - no evident size increase noted in the 4th ventricle - mild enlargement of the external csf - severe bilateral enlargement of the inf. lateral ventricle - mild-to-moderate enlargement of the left lateral ventricle and mild enlargement of the right lateral ventricle - mild enlargement of the 3rd ventricle	SV	We have the following subject's personal information: - The subject is a male of 69.0 years old. - He has 20.0 years of education (equivalent to doctorate) We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 28. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for keeping track of current events, for remembering appointments, family occasions, holidays, medications. The subject has difficulity, but does by himself, for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for paying attention to and understanding a TV program, book, or magazine. The subject requires assitance for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for traveling out of the neighborhood, driving, or arranging to take public transportation. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in motor disturbance, appetite and eating, a mild (noticeable, but not significant) change in agitation or aggression, elation or euphoria, apathy or indifference, irritability or lability. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 3.0. --- ## 📋 Detailed Domain Scores * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_941_S_10659_MR_Accelerated_Sagittal_MPRAGE_MSV21_br_raw_20250408190849005_1_I11185475	On a T1-weighted brain MRI we observed: For the ventricles: - external csf appears within normal size limits with no apparent enlargement - lateral ventricle maintains its expected proportions without signs of enlargement - inf. lateral ventricle appears within normal size limits with no apparent enlargement - the 4th ventricle shows no notable changes suggestive of enlargement - no clear enlargement or abnormal growth seen in the 3rd ventricle For the cerebral cortex: - no appreciable degenerative or atrophic changes observed in the temporal lobe - frontal lobe appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the insular cortex - parietal lobe appears within normal limits without apparent atrophy - limbic cortex appears preserved, with no observable tissue loss - occipital lobe appears preserved, with no observable tissue loss For the subcortical structures: - hippocampus maintains a normal appearance with no observable atrophic features - no evident atrophy or tissue thinning seen in the pallidum - the accumbens shows no notable changes suggestive of atrophy - amygdala appears preserved, with no observable tissue loss - putamen demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the thalamus - no appreciable degenerative or atrophic changes observed in the caudate	CN	We have the following subject's personal information: - The subject is a female of 64.7 years old. - Subject's current marrietal status is: married. - She has 20.0 years of education (equivalent to doctorate) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 13. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care.
ADNI_041_S_6226_MR_Accelerated_Sagittal_MPRAGE__br_raw_20180402142608910_71_S672440_I980386	On a T1-weighted brain MRI we observed: For the subcortical structures: - amygdala appears within normal limits without apparent atrophy - thalamus demonstrates a healthy morphology without signs of atrophy - no clear atrophic alterations are visible in the caudate - pallidum demonstrates a healthy morphology without signs of atrophy - hippocampus demonstrates a healthy morphology without signs of atrophy - no appreciable degenerative or atrophic changes observed in the putamen - no evident atrophy or tissue thinning seen in the accumbens For the ventricles: - no evident size increase noted in the external csf - inf. lateral ventricle appears within normal size limits with no apparent enlargement - 3rd ventricle appears within normal size limits with no apparent enlargement - 4th ventricle maintains its expected proportions without signs of enlargement - no findings suggestive of enlargement are seen in the lateral ventricle For the cerebral cortex: - limbic cortex appears within normal limits without apparent atrophy - the insular cortex shows no notable changes suggestive of atrophy - no observable atrophic changes in the occipital lobe - no appreciable degenerative or atrophic changes observed in the frontal lobe - the temporal lobe shows no notable changes suggestive of atrophy - no findings suggestive of atrophy are seen in the parietal lobe	CN	We have the following subject's personal information: - The subject is a female of 65.5 years old. We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 25 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, her total number of seconds to complete is 20. On the Trail Making Test Part B, her total number of seconds to complete is 70. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_041_S_4513_MR_MT1__GradWarp__N3m_Br_20160527103203163_S383485_I717789	On a T1-weighted brain MRI we observed: For the ventricles: - no observable enlargement of the inf. lateral ventricle - mild enlargement of the 3rd ventricle - mild enlargement of the 4th ventricle - mild enlargement of the external csf - mild enlargement of the right lateral ventricle; normal-to-mild enlargement of the left lateral ventricle For the cerebral cortex: - occipital lobe appears within normal limits without apparent atrophy - frontal lobe appears within normal limits without apparent atrophy - parietal lobe maintains a normal appearance with no observable atrophic features - temporal lobe maintains a normal appearance with no observable atrophic features - no observable atrophic changes in the insular cortex - the limbic cortex shows no notable changes suggestive of atrophy For the subcortical structures: - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - mild bilateral atrophy of the thalamus - accumbens demonstrates a healthy morphology without signs of atrophy - no clear atrophic alterations are visible in the caudate - mild atrophy of the right pallidum; normal-to-mild atrophy of the left pallidum - amygdala maintains a normal appearance with no observable atrophic features - putamen maintains a normal appearance with no observable atrophic features	CN	We have the following subject's personal information: - The subject is a male of 64.7 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - The subject has a Boston Naming Test (BNT) total score of 29. - On the semantic categorical fluency test, the subject named 29 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 16. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 28. On the Trail Making Test Part B, his total number of seconds to complete is 70. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
FTLD_203117259_02951_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10178070	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild atrophy of the left hippocampus - amygdala appears within normal limits without apparent atrophy - moderate atrophy of the left caudate and mild atrophy of the right caudate - moderate atrophy of the left thalamus; the right thalamus is normal - moderate atrophy of the left putamen; normal-to-mild atrophy of the right putamen - moderate atrophy of the left pallidum and mild atrophy of the right pallidum - mild-to-moderate atrophy of the left accumbens; normal-to-mild atrophy of the right accumbens For the ventricles: - mild enlargement of the external csf - severe enlargement of the 3rd ventricle - severe enlargement of the left inf. lateral ventricle and mild enlargement of the right inf. lateral ventricle - mild enlargement of the 4th ventricle - severe enlargement of the left lateral ventricle and mild-to-moderate enlargement of the right lateral ventricle For the cerebral cortex: - no findings suggestive of atrophy are seen in the limbic cortex - mild atrophy of the left insular cortex; the right insular cortex is normal; focal volume loss observed in the following subregions: anterior insula (mild atrophy on the left and normal-to-mild atrophy on the right) and frontal operculum (mild atrophy on the left and normal-to-mild atrophy on the right) - mild bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: temporal pole (normal-to-mild atrophy on the left and mild atrophy on the right) - no appreciable degenerative or atrophic changes observed in the occipital lobe - no appreciable degenerative or atrophic changes observed in the parietal lobe - mild atrophy of the left frontal lobe; the right frontal lobe is normal; focal volume loss observed in the following subregions: triangular inf. frontal gyrus (mild atrophy both left and right), middle frontal gyrus (mild atrophy on the left and normal on the right) and posterior orbital gyrus (mild atrophy on the left and normal on the right)	BV	We have the following subject's personal information: - The subject is a male of 55.0 years old. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 15. - On the semantic categorical fluency test, the subject named 3 animals in 60 seconds. - On the Number Span forward test, his longest span forward was 5. On the Number Span backward test, his longest span backward was 3. - On the Trail Making Test Part A, his total number of seconds to complete is 150, his number of commission errors is 2, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in apathy or indifference, nighttime behaviors, a moderate (significant, but not dramatic) change in agitation or aggression, depression or dysphoria, irritability or lability, motor disturbance, appetite and eating. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 3.0, corresponding to severe impairment. His standard CDR Sum of Boxes score is 13.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 2.0 (moderate impairment). Description: Severe difficulty with time relationships; usually disoriented to time, often to place. * Judgment and problem-solving: Score 3.0 (severe impairment). Description: Unable to make judgments or solve problems. * Community affairs: Score 3.0 (severe impairment). Description: No pretense of independent function outside the home; appears too ill to be taken to functions outside the family home. * Home and hobbies: Score 3.0 (severe impairment). Description: No significant function in the home. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. * Behavior, comportment, and personality: Score 3.0 (severe impairment). Description: Severe behavioral changes, making interpersonal interactions all unidirectional. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
ADNI_035_S_4114_MR_MPRAGE_GRAPPA2_br_raw_20130729120222694_144_S196804_I382919	On a T1-weighted brain MRI we observed: For the subcortical structures: - no observable atrophic changes in the amygdala - caudate appears within normal limits without apparent atrophy - pallidum appears preserved, with no observable tissue loss - no observable atrophic changes in the hippocampus - mild atrophy of the left accumbens; normal-to-mild atrophy of the right accumbens - mild bilateral atrophy of the putamen - the thalamus shows no notable changes suggestive of atrophy For the ventricles: - mild enlargement of the 4th ventricle - mild enlargement of the external csf - no observable enlargement of the 3rd ventricle - lateral ventricle maintains its expected proportions without signs of enlargement - no observable enlargement of the inf. lateral ventricle For the cerebral cortex: - no findings suggestive of atrophy are seen in the limbic cortex - no clear atrophic alterations are visible in the occipital lobe - temporal lobe appears preserved, with no observable tissue loss - no evident atrophy or tissue thinning seen in the parietal lobe - mild bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: anterior insula (mild-to-moderate atrophy both left and right), posterior insula (mild atrophy on the left and mild-to-moderate atrophy on the right) and frontal operculum (mild atrophy on the left) - no evident atrophy or tissue thinning seen in the frontal lobe	AD	We have the following subject's personal information: - The subject is a female of 57.1 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 27. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 3. - The subject has a Boston Naming Test (BNT) total score of 30. - On the semantic categorical fluency test, the subject named 17 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 0. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject has difficulity, but does by himself, for writing checks, paying bills, or balancing a checkbook, for keeping track of current events. - On the Trail Making Test Part A, her total number of seconds to complete is 22. On the Trail Making Test Part B, her total number of seconds to complete is 85. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. Her standard CDR Sum of Boxes score is 1.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
NIFD_1_S_0202_MR_T1_mprage_S3_DIS3D_br_raw_20170817131148687_130_S597998_I891534	On a T1-weighted brain MRI we observed: For the cerebral cortex: - occipital lobe maintains a normal appearance with no observable atrophic features - temporal lobe maintains a normal appearance with no observable atrophic features - no clear atrophic alterations are visible in the parietal lobe - no evident atrophy or tissue thinning seen in the frontal lobe - no observable atrophic changes in the limbic cortex - no appreciable degenerative or atrophic changes observed in the insular cortex For the ventricles: - no findings suggestive of enlargement are seen in the 4th ventricle - no appreciable enlargement noted in the external csf - no observable enlargement of the inf. lateral ventricle - no observable enlargement of the lateral ventricle - 3rd ventricle maintains its expected proportions without signs of enlargement For the subcortical structures: - hippocampus maintains a normal appearance with no observable atrophic features - caudate appears preserved, with no observable tissue loss - pallidum appears preserved, with no observable tissue loss - no observable atrophic changes in the putamen - thalamus appears preserved, with no observable tissue loss - no evident atrophy or tissue thinning seen in the amygdala - no observable atrophic changes in the accumbens	CN	We have the following subject's personal information: - The subject is a female of 54.0 years old. - She has 18.0 years of education (equivalent to master’s degree) We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. - The subject has a Montreal Cognitive Assessment (MoCA) total score, corrected for education, of 27. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1.
ADNI_005_S_0221_MR_MPR__GradWarp__B1_Correction__N3__Scaled_Br_20070910164745994_S11958_I72128	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild atrophy of the right thalamus; normal-to-mild atrophy of the left thalamus - mild bilateral atrophy of the putamen - no appreciable degenerative or atrophic changes observed in the accumbens - mild atrophy of the left pallidum; normal-to-mild atrophy of the right pallidum - mild-to-moderate atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus - mild atrophy of the right caudate; the left caudate is normal - moderate atrophy of the left amygdala and mild-to-moderate atrophy of the right amygdala For the ventricles: - mild enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle - no clear enlargement or abnormal growth seen in the external csf - the 3rd ventricle shows no notable changes suggestive of enlargement - mild enlargement of the left lateral ventricle and mild-to-moderate enlargement of the right lateral ventricle - 4th ventricle maintains a typical volume without observable enlargement For the cerebral cortex: - insular cortex appears within normal limits without apparent atrophy - mild atrophy of the right parietal lobe; the left parietal lobe is normal; focal volume loss observed in the following subregions: sup. parietal lobule (normal on the left and mild atrophy on the right) and angular gyrus (normal on the left and mild atrophy on the right) - no appreciable degenerative or atrophic changes observed in the frontal lobe - no appreciable degenerative or atrophic changes observed in the temporal lobe - no appreciable degenerative or atrophic changes observed in the limbic cortex - no observable atrophic changes in the occipital lobe	AD	We have the following subject's personal information: - The subject is a male of 67.5 years old. - Subject's current marrietal status is: married. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following subject's health history information: - He has a remote/inactive history of substance abuse (drug). We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 20. In his MMSE test, he has an orientation to time score of 1. In his MMSE test, he has an orientation to place score of 3.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 0. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. His standard CDR Sum of Boxes score is 7.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 2.0 (moderate impairment). Description: Only simple chores preserved; very restricted interests, poorly maintained. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. From genetic data, APOE genotype is e4,e4 with 2 copies of e4 allele.
ADNI_027_S_5093_MR_Accelerated_Sag_IR-FSPGR_br_raw_20130227194045244_43_S183315_I361524	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no clear atrophic alterations are visible in the occipital lobe - temporal lobe maintains a normal appearance with no observable atrophic features - no findings suggestive of atrophy are seen in the insular cortex - frontal lobe appears within normal limits without apparent atrophy - the parietal lobe shows no notable changes suggestive of atrophy - no evident atrophy or tissue thinning seen in the limbic cortex For the subcortical structures: - no findings suggestive of atrophy are seen in the caudate - no appreciable degenerative or atrophic changes observed in the putamen - thalamus appears within normal limits without apparent atrophy - no observable atrophic changes in the accumbens - amygdala appears within normal limits without apparent atrophy - no appreciable degenerative or atrophic changes observed in the pallidum - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus For the ventricles: - inf. lateral ventricle appears within normal size limits with no apparent enlargement - no clear enlargement or abnormal growth seen in the 3rd ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - no evident size increase noted in the lateral ventricle - external csf appears within normal size limits with no apparent enlargement	CN	We have the following subject's personal information: - The subject is a female of 69.4 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 30. - On the semantic categorical fluency test, the subject named 19 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, her total number of seconds to complete is 27. On the Trail Making Test Part B, her total number of seconds to complete is 63. From genetic data, APOE genotype is e3,e3 with no e4 allele.
FTLD_203494939_02939_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10178263	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no observable atrophic changes in the occipital lobe - mild atrophy of the right temporal lobe; the left temporal lobe is normal; focal volume loss observed in the following subregions: middle temporal gyrus (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right) and temporal pole (mild atrophy on the left and normal-to-mild atrophy on the right) - no clear atrophic alterations are visible in the parietal lobe - mild atrophy of the left insular cortex and mild-to-moderate atrophy of the right insular cortex; focal volume loss observed in the following subregions: anterior insula (moderate atrophy both left and right), frontal operculum (mild atrophy both left and right) and posterior insula (mild atrophy on the left and normal on the right) - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild-to-moderate atrophy both left and right) - mild atrophy of the left frontal lobe and moderate atrophy of the right frontal lobe; focal volume loss observed in the following subregions: gyrus rectus (moderate atrophy both left and right), frontal pole (mild atrophy on the left and mild-to-moderate atrophy on the right), medial frontal cortex (mild atrophy on the left and mild-to-moderate atrophy on the right), medial orbital gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), posterior orbital gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), anterior orbital gyrus (mild atrophy both left and right), lateral orbital gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), sup. frontal gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), opercular inf. frontal gyrus (normal on the left and mild atrophy on the right), middle frontal gyrus (normal on the left and mild atrophy on the right), sup. frontal gyrus medial segment (normal on the left and mild atrophy on the right), orbital inf. frontal gyrus (normal on the left and mild atrophy on the right) and triangular inf. frontal gyrus (mild atrophy on the right) For the subcortical structures: - pallidum demonstrates a healthy morphology without signs of atrophy - mild atrophy of the right putamen; normal-to-mild atrophy of the left putamen - no clear atrophic alterations are visible in the thalamus - hippocampus maintains a normal appearance with no observable atrophic features - mild-to-moderate atrophy of the right amygdala; the left amygdala is normal - mild atrophy of the right accumbens; the left accumbens is normal - the caudate shows no notable changes suggestive of atrophy For the ventricles: - no findings suggestive of enlargement are seen in the inf. lateral ventricle - moderate enlargement of the external csf - 3rd ventricle maintains its expected proportions without signs of enlargement - no evident size increase noted in the lateral ventricle - 4th ventricle appears to be of normal dimensions, with no observable increase in size	BV	We have the following subject's personal information: - The subject is a female of 59.0 years old. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 27. - On the semantic categorical fluency test, the subject named 9 animals in 60 seconds. She named 9 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 6. - On the Number Span forward test, her longest span forward was 5. On the Number Span backward test, her longest span backward was 4. - On the Trail Making Test Part A, her total number of seconds to complete is 45, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 300, her number of commission errors is 18, her number of correct lines is 1. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in agitation or aggression, irritability or lability, nighttime behaviors, a moderate (significant, but not dramatic) change in delusions, anxiety, elation or euphoria, apathy or indifference, appetite and eating, a mild (noticeable, but not significant) change in motor disturbance. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
FTLD_203087510_03018_MR_Accelerated_Sagittal_MPRAGE_br_raw_20240_I10450161	On a T1-weighted brain MRI we observed: For the cerebral cortex: - mild-to-moderate atrophy of the left temporal lobe and moderate atrophy of the right temporal lobe; focal volume loss observed in the following subregions: middle temporal gyrus (mild-to-moderate atrophy both left and right), inf. temporal gyrus (mild atrophy both left and right) and temporal pole (normal-to-mild atrophy on the left and mild atrophy on the right) - mild-to-moderate atrophy of the right limbic cortex; normal-to-mild atrophy of the left limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right) - no observable atrophic changes in the parietal lobe - no clear atrophic alterations are visible in the occipital lobe - moderate bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: middle frontal gyrus (mild-to-moderate atrophy both left and right), sup. frontal gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), frontal pole (mild atrophy both left and right), medial orbital gyrus (mild atrophy both left and right), anterior orbital gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), gyrus rectus (normal on the left and mild atrophy on the right), medial frontal cortex (normal on the left and mild atrophy on the right), lateral orbital gyrus (mild atrophy on the left and normal on the right) and sup. frontal gyrus medial segment (mild atrophy on the left and normal on the right) - mild-to-moderate bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: anterior insula (mild atrophy on the left and mild-to-moderate atrophy on the right), posterior insula (mild atrophy both left and right), frontal operculum (normal-to-mild atrophy on the left and mild atrophy on the right) and parietal operculum (mild atrophy on the left and normal-to-mild atrophy on the right) For the ventricles: - mild-to-moderate enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle - moderate bilateral enlargement of the lateral ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - mild-to-moderate enlargement of the 3rd ventricle - moderate enlargement of the external csf For the subcortical structures: - mild atrophy of the right thalamus; normal-to-mild atrophy of the left thalamus - pallidum demonstrates a healthy morphology without signs of atrophy - mild-to-moderate atrophy of the left accumbens and mild atrophy of the right accumbens - mild atrophy of the left amygdala and moderate atrophy of the right amygdala - normal-to-mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - mild atrophy of the left putamen and mild-to-moderate atrophy of the right putamen - moderate bilateral atrophy of the caudate	BV	We have the following subject's personal information: - The subject is a male of 62.0 years old. - He has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 2.0, corresponding to moderate impairment. His standard CDR Sum of Boxes score is 12.0. --- ## 📋 Detailed Domain Scores * Memory: Score 2.0 (moderate impairment). Description: Severe memory loss; only highly learned material retained; new material rapidly lost. * Orientation: Score 2.0 (moderate impairment). Description: Severe difficulty with time relationships; usually disoriented to time, often to place. * Judgment and problem-solving: Score 2.0 (moderate impairment). Description: Severely impaired in handling problems, similarities, and differences; social judgment usually impaired. * Community affairs: Score 2.0 (moderate impairment). Description: No pretense of independent function outside the home; appears well enough to be taken to functions outside the family home. * Home and hobbies: Score 2.0 (moderate impairment). Description: Only simple chores preserved; very restricted interests, poorly maintained. * Personal care: Score 2.0 (moderate impairment). Description: Requires much help with personal care; frequent incontinence. * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
NIFD_1_S_0344_MR_T1_mprage_S3_DIS3D_br_raw_20170629022309014_112_S578105_I867948	On a T1-weighted brain MRI we observed: For the cerebral cortex: - mild bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: anterior insula (mild atrophy on the left and normal-to-mild atrophy on the right) and parietal operculum (mild atrophy on the left and normal on the right) - mild atrophy of the left temporal lobe; the right temporal lobe is normal; focal volume loss observed in the following subregions: temporal pole (mild atrophy on the left and normal on the right) - no evident atrophy or tissue thinning seen in the occipital lobe - limbic cortex appears within normal limits without apparent atrophy - mild atrophy of the left frontal lobe and mild-to-moderate atrophy of the right frontal lobe; focal volume loss observed in the following subregions: medial frontal cortex (mild-to-moderate atrophy on the left and mild atrophy on the right), gyrus rectus (mild-to-moderate atrophy on the left and normal-to-mild atrophy on the right), middle frontal gyrus (mild atrophy both left and right), sup. frontal gyrus medial segment (normal on the left and mild atrophy on the right), posterior orbital gyrus (normal on the left and mild atrophy on the right) and precentral gyrus (normal on the left and mild atrophy on the right) - no clear atrophic alterations are visible in the parietal lobe For the ventricles: - moderate bilateral enlargement of the inf. lateral ventricle - mild enlargement of the external csf - moderate enlargement of the left lateral ventricle and moderate-to-severe enlargement of the right lateral ventricle - no findings suggestive of enlargement are seen in the 4th ventricle - mild enlargement of the 3rd ventricle For the subcortical structures: - no evident atrophy or tissue thinning seen in the caudate - putamen appears preserved, with no observable tissue loss - mild bilateral atrophy of the pallidum - mild-to-moderate atrophy of the right amygdala; normal-to-mild atrophy of the left amygdala - mild atrophy of the left thalamus and mild-to-moderate atrophy of the right thalamus - mild atrophy of the left accumbens and mild-to-moderate atrophy of the right accumbens - mild-to-moderate atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus	BV	We have the following subject's personal information: - The subject is a female of 67.0 years old. - She has 14.0 years of education We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 22. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 8. - On the Functional Activities Questionnaire (FAQ), the subject has difficulity, but does by himself, for heating water, making a cup of coffee, turning off the stove, for paying attention to and understanding a TV program, book, or magazine. The subject requires assitance for writing checks, paying bills, or balancing a checkbook, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for preparing a balanced meal, for keeping track of current events, for remembering appointments, family occasions, holidays, medications. The subject is dependent for assembling tax records, business affairs, or other paper, for traveling out of the neighborhood, driving, or arranging to take public transportation. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in delusions, hallucinations, anxiety, elation or euphoria, apathy or indifference, motor disturbance, appetite and eating. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 2.0, corresponding to moderate impairment. Her standard CDR Sum of Boxes score is 8.0. --- ## 📋 Detailed Domain Scores * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 0.5 (questionnable impairment). Description: Consistent mild word-finding difficulties; simplification of word choice; circumlocution; decreased phrase length; and/or mild comprehension difficulties.
ADNI_035_S_7076_MR_Accelerated_Sagittal_MPRAGE_Phase_A-P__br_raw_20220525102710525_73_S1136252_I1584200	On a T1-weighted brain MRI we observed: For the subcortical structures: - accumbens appears preserved, with no observable tissue loss - the thalamus shows no notable changes suggestive of atrophy - mild atrophy of the right amygdala; normal-to-mild atrophy of the left amygdala - the putamen shows no notable changes suggestive of atrophy - no clear atrophic alterations are visible in the caudate - hippocampus appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the pallidum For the cerebral cortex: - no observable atrophic changes in the insular cortex - no evident atrophy or tissue thinning seen in the parietal lobe - no clear atrophic alterations are visible in the frontal lobe - no appreciable degenerative or atrophic changes observed in the occipital lobe - no clear atrophic alterations are visible in the limbic cortex - mild atrophy of the right temporal lobe; the left temporal lobe is normal; focal volume loss observed in the following subregions: temporal pole (mild atrophy on the left and normal on the right) and middle temporal gyrus (mild atrophy on the right) For the ventricles: - 3rd ventricle maintains its expected proportions without signs of enlargement - lateral ventricle appears to be of normal dimensions, with no observable increase in size - 4th ventricle appears within normal size limits with no apparent enlargement - no appreciable enlargement noted in the inf. lateral ventricle - external csf appears to be of normal dimensions, with no observable increase in size	CN	We have the following subject's personal information: - The subject is a female of 62.9 years old. - Subject's current marrietal status is: widowed. - She has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 3. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 12. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_014_S_4039_MR_MPRAGE_br_raw_20110603075656539_127_S110533_I238745	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no appreciable degenerative or atrophic changes observed in the occipital lobe - mild-to-moderate atrophy of the left parietal lobe and mild atrophy of the right parietal lobe; focal volume loss observed in the following subregions: precuneus (moderate atrophy on the left and mild-to-moderate atrophy on the right) and angular gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) - the frontal lobe shows no notable changes suggestive of atrophy - mild atrophy of the right insular cortex; the left insular cortex is normal; focal volume loss observed in the following subregions: central operculum (mild atrophy both left and right) - mild atrophy of the left temporal lobe and mild-to-moderate atrophy of the right temporal lobe; focal volume loss observed in the following subregions: middle temporal gyrus (mild atrophy both left and right), fusiform gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), sup. temporal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) and transverse temporal gyrus (normal on the left and mild atrophy on the right) - the limbic cortex shows no notable changes suggestive of atrophy For the subcortical structures: - mild atrophy of the right hippocampus - mild atrophy of the left amygdala and mild-to-moderate atrophy of the right amygdala - no observable atrophic changes in the putamen - mild atrophy of the left caudate; normal-to-mild atrophy of the right caudate - mild atrophy of the right accumbens; normal-to-mild atrophy of the left accumbens - pallidum demonstrates a healthy morphology without signs of atrophy - thalamus demonstrates a healthy morphology without signs of atrophy For the ventricles: - mild enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle - mild enlargement of the left lateral ventricle and mild-to-moderate enlargement of the right lateral ventricle - 4th ventricle appears to be of normal dimensions, with no observable increase in size - mild enlargement of the 3rd ventricle - moderate enlargement of the external csf	AD	We have the following subject's personal information: - The subject is a male of 56.0 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 27. - On the semantic categorical fluency test, the subject named 12 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for paying attention to and understanding a TV program, book, or magazine. The subject has difficulity, but does by himself, for writing checks, paying bills, or balancing a checkbook, for shopping alone for clothes, household necessities, or groceries. The subject requires assitance for preparing a balanced meal, for keeping track of current events, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject is dependent for assembling tax records, business affairs, or other paper, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove. - On the Trail Making Test Part A, his total number of seconds to complete is 112. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_033_S_1281_MR_MPR-R__GradWarp__B1_Correction__N3__Scaled_Br_20070517161803030_S26136_I54780	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild-to-moderate bilateral atrophy of the amygdala - mild-to-moderate atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus - pallidum appears preserved, with no observable tissue loss - caudate maintains a normal appearance with no observable atrophic features - mild atrophy of the left accumbens; normal-to-mild atrophy of the right accumbens - no evident atrophy or tissue thinning seen in the thalamus - putamen appears preserved, with no observable tissue loss For the ventricles: - 4th ventricle maintains its expected proportions without signs of enlargement - mild enlargement of the right inf. lateral ventricle; normal-to-mild enlargement of the left inf. lateral ventricle - mild enlargement of the external csf - no findings suggestive of enlargement are seen in the lateral ventricle - 3rd ventricle maintains a typical volume without observable enlargement For the cerebral cortex: - mild atrophy of the left temporal lobe and mild-to-moderate atrophy of the right temporal lobe; focal volume loss observed in the following subregions: middle temporal gyrus (normal on the left and mild atrophy on the right) - no clear atrophic alterations are visible in the parietal lobe - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: parahippocampal gyrus (mild atrophy both left and right), entorhinal area (normal on the left and mild atrophy on the right) and posterior cingulate gyrus (mild atrophy on the left) - no clear atrophic alterations are visible in the frontal lobe - insular cortex appears preserved, with no observable tissue loss - occipital lobe maintains a normal appearance with no observable atrophic features	AD	We have the following subject's personal information: - The subject is a female of 77.7 years old. - Subject's current marrietal status is: married. - She has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 25. In her MMSE test, she has an orientation to time score of 3. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 0. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e4,e4 with 2 copies of e4 allele.
FTLD_203340631_03134_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10177156	On a T1-weighted brain MRI we observed: For the ventricles: - no findings suggestive of enlargement are seen in the 4th ventricle - mild-to-moderate enlargement of the 3rd ventricle - mild-to-moderate enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle - lateral ventricle appears to be of normal dimensions, with no observable increase in size - mild-to-moderate enlargement of the external csf For the cerebral cortex: - no observable atrophic changes in the frontal lobe - no findings suggestive of atrophy are seen in the insular cortex - mild atrophy of the right limbic cortex; normal-to-mild atrophy of the left limbic cortex; focal volume loss observed in the following subregions: entorhinal area (mild atrophy both left and right), parahippocampal gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) and anterior cingulate gyrus (normal on the left and mild atrophy on the right) - no observable atrophic changes in the parietal lobe - mild bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: temporal pole (mild-to-moderate atrophy on the left and mild atrophy on the right) and inf. temporal gyrus (mild atrophy on the left and normal on the right) - occipital lobe maintains a normal appearance with no observable atrophic features For the subcortical structures: - mild bilateral atrophy of the caudate - normal-to-mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - moderate atrophy of the left amygdala and moderate-to-severe atrophy of the right amygdala - mild atrophy of the right pallidum; the left pallidum is normal - mild bilateral atrophy of the thalamus - mild atrophy of the left accumbens and mild-to-moderate atrophy of the right accumbens - putamen appears within normal limits without apparent atrophy	BV	We have the following subject's personal information: - The subject is a male of 65.0 years old. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 24. - On the semantic categorical fluency test, the subject named 16 animals in 60 seconds. He named 4 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 6. - On the Number Span forward test, his longest span forward was 7. On the Number Span backward test, his longest span backward was 3. - On the Trail Making Test Part A, his total number of seconds to complete is 38, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 101, his number of commission errors is 0, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in anxiety, disinhibition, irritability or lability, a mild (noticeable, but not significant) change in agitation or aggression, apathy or indifference, appetite and eating. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 2.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 0.5 (questionnable impairment). Description: Consistent mild word-finding difficulties; simplification of word choice; circumlocution; decreased phrase length; and/or mild comprehension difficulties.
ADNI_005_S_4168_MR_Accelerated_Sag_IR-FSPGR___br_raw_20150915160304103_97_S274175_I511913	On a T1-weighted brain MRI we observed: For the ventricles: - external csf maintains a typical volume without observable enlargement - no clear enlargement or abnormal growth seen in the lateral ventricle - mild enlargement of the right inf. lateral ventricle; the left inf. lateral ventricle is normal - no findings suggestive of enlargement are seen in the 4th ventricle - 3rd ventricle maintains its expected proportions without signs of enlargement For the cerebral cortex: - parietal lobe demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the frontal lobe - no findings suggestive of atrophy are seen in the insular cortex - limbic cortex demonstrates a healthy morphology without signs of atrophy - occipital lobe appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the temporal lobe For the subcortical structures: - no observable atrophic changes in the hippocampus - no evident atrophy or tissue thinning seen in the accumbens - no findings suggestive of atrophy are seen in the caudate - thalamus demonstrates a healthy morphology without signs of atrophy - amygdala demonstrates a healthy morphology without signs of atrophy - putamen maintains a normal appearance with no observable atrophic features - mild atrophy of the left pallidum; the right pallidum is normal	CN	We have the following subject's personal information: - The subject is a male of 86.2 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - The subject has a Boston Naming Test (BNT) total score of 30. - On the semantic categorical fluency test, the subject named 19 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 13. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject has difficulity, but does by himself, for paying attention to and understanding a TV program, book, or magazine. - On the Trail Making Test Part A, his total number of seconds to complete is 30. On the Trail Making Test Part B, his total number of seconds to complete is 69. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_035_S_4785_MR_MPRAGE_br_raw_20130610130959862_140_S191865_I375886	On a T1-weighted brain MRI we observed: For the ventricles: - no findings suggestive of enlargement are seen in the external csf - 4th ventricle appears to be of normal dimensions, with no observable increase in size - no observable enlargement of the lateral ventricle - no appreciable enlargement noted in the 3rd ventricle - no appreciable enlargement noted in the inf. lateral ventricle For the subcortical structures: - the thalamus shows no notable changes suggestive of atrophy - no evident atrophy or tissue thinning seen in the pallidum - mild atrophy of the right hippocampus - caudate appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the putamen - amygdala demonstrates a healthy morphology without signs of atrophy - the accumbens shows no notable changes suggestive of atrophy For the cerebral cortex: - limbic cortex demonstrates a healthy morphology without signs of atrophy - frontal lobe appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the insular cortex - mild atrophy of the left occipital lobe; the right occipital lobe is normal; focal volume loss observed in the following subregions: cuneus (normal on the left and mild atrophy on the right) and calcarine cortex (mild atrophy on the left and normal on the right) - mild atrophy of the left parietal lobe; the right parietal lobe is normal; focal volume loss observed in the following subregions: sup. parietal lobule (mild atrophy on the left) - the temporal lobe shows no notable changes suggestive of atrophy	CN	We have the following subject's personal information: - The subject is a female of 66.8 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 29. - On the semantic categorical fluency test, the subject named 20 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject has difficulity, but does by himself, for keeping track of current events, for remembering appointments, family occasions, holidays, medications. - On the Trail Making Test Part A, her total number of seconds to complete is 20. On the Trail Making Test Part B, her total number of seconds to complete is 48. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_137_S_4815_MR_MPRAGE_br_raw_20140829141559486_65_S228826_I441091	On a T1-weighted brain MRI we observed: For the subcortical structures: - no findings suggestive of atrophy are seen in the pallidum - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - caudate appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the amygdala - no observable atrophic changes in the thalamus - accumbens maintains a normal appearance with no observable atrophic features - no clear atrophic alterations are visible in the putamen For the ventricles: - no observable enlargement of the external csf - mild bilateral enlargement of the inf. lateral ventricle - no evident size increase noted in the lateral ventricle - no evident size increase noted in the 3rd ventricle - no findings suggestive of enlargement are seen in the 4th ventricle For the cerebral cortex: - occipital lobe appears preserved, with no observable tissue loss - temporal lobe demonstrates a healthy morphology without signs of atrophy - no observable atrophic changes in the parietal lobe - no appreciable degenerative or atrophic changes observed in the limbic cortex - no appreciable degenerative or atrophic changes observed in the frontal lobe - no appreciable degenerative or atrophic changes observed in the insular cortex	AD	We have the following subject's personal information: - The subject is a female of 72.0 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 24. In her MMSE test, she has an orientation to time score of 2. In her MMSE test, she has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 5. - The subject has a Boston Naming Test (BNT) total score of 24. - On the semantic categorical fluency test, the subject named 15 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 0. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for heating water, making a cup of coffee, turning off the stove. The subject has difficulity, but does by himself, for shopping alone for clothes, household necessities, or groceries, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject requires assitance for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for playing a game of skill such as bridge or chess, working on a hobby, for preparing a balanced meal, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications. The subject is dependent for keeping track of current events. - On the Trail Making Test Part A, her total number of seconds to complete is 45. On the Trail Making Test Part B, her total number of seconds to complete is 127. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e4,e4 with 2 copies of e4 allele.
FTLD_203320313_03312_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10176943	On a T1-weighted brain MRI we observed: For the ventricles: - external csf maintains a typical volume without observable enlargement - mild enlargement of the 3rd ventricle - moderate-to-severe bilateral enlargement of the inf. lateral ventricle - mild-to-moderate enlargement of the left lateral ventricle and moderate enlargement of the right lateral ventricle - no observable enlargement of the 4th ventricle For the subcortical structures: - mild bilateral atrophy of the amygdala - caudate appears preserved, with no observable tissue loss - thalamus appears preserved, with no observable tissue loss - no clear atrophic alterations are visible in the pallidum - the putamen shows no notable changes suggestive of atrophy - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - mild atrophy of the left accumbens; the right accumbens is normal For the cerebral cortex: - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: entorhinal area (mild atrophy both left and right), anterior cingulate gyrus (mild atrophy on the left and normal on the right) and posterior cingulate gyrus (normal on the left and mild atrophy on the right) - mild atrophy of the left frontal lobe; normal-to-mild atrophy of the right frontal lobe; focal volume loss observed in the following subregions: gyrus rectus (mild atrophy both left and right), precentral gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), medial frontal cortex (normal on the left and mild atrophy on the right), sup. frontal gyrus (mild atrophy on the left and normal on the right), frontal pole (normal on the left and mild atrophy on the right) and medial orbital gyrus (normal on the left and mild atrophy on the right) - mild atrophy of the left occipital lobe; the right occipital lobe is normal; focal volume loss observed in the following subregions: middle occipital gyrus (mild atrophy on the left), sup. occipital gyrus (normal on the left and mild atrophy on the right), cuneus (mild atrophy on the left and normal on the right), occipital fusiform gyrus (mild atrophy on the left) and occipital pole (normal on the left and mild atrophy on the right) - the parietal lobe shows no notable changes suggestive of atrophy - mild bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: inf. temporal gyrus (mild atrophy on the left and normal on the right), temporal pole (mild atrophy on the left and normal on the right) and middle temporal gyrus (normal on the left and mild atrophy on the right) - insular cortex maintains a normal appearance with no observable atrophic features	SV	We have the following subject's personal information: - The subject is a female of 79.0 years old. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 0. - On the semantic categorical fluency test, the subject named 7 animals in 60 seconds. She named 1 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 2. - On the Number Span forward test, her longest span forward was 7. On the Number Span backward test, her longest span backward was 6. - On the Trail Making Test Part A, her total number of seconds to complete is 47, her number of commission errors is 0, her number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in irritability or lability. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. Her standard CDR Sum of Boxes score is 3.5. --- ## 📋 Detailed Domain Scores * Memory: Score 2.0 (moderate impairment). Description: Severe memory loss; only highly learned material retained; new material rapidly lost. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 1.0 (mild impairment). Description: Moderate word-finding difficulty in speech; cannot name objects in environment; reduced phrase length and/or agrammatical speech and/or reduced comprehension in conversation and reading.
ADNI_941_S_6471_MR_Accelerated_Sagittal_MPRAGE__br_raw_20180702130452790_67_S700583_I1016136	On a T1-weighted brain MRI we observed: For the subcortical structures: - no findings suggestive of atrophy are seen in the amygdala - no appreciable degenerative or atrophic changes observed in the thalamus - no clear atrophic alterations are visible in the caudate - accumbens maintains a normal appearance with no observable atrophic features - no appreciable degenerative or atrophic changes observed in the pallidum - no evident atrophy or tissue thinning seen in the putamen - the hippocampus shows no notable changes suggestive of atrophy For the cerebral cortex: - no appreciable degenerative or atrophic changes observed in the limbic cortex - insular cortex appears preserved, with no observable tissue loss - no observable atrophic changes in the temporal lobe - mild bilateral atrophy of the parietal lobe; focal volume loss observed in the following subregions: sup. parietal lobule (mild atrophy on the left and normal-to-mild atrophy on the right) and precuneus (normal on the left and mild atrophy on the right) - no appreciable degenerative or atrophic changes observed in the frontal lobe - no clear atrophic alterations are visible in the occipital lobe For the ventricles: - no appreciable enlargement noted in the external csf - no clear enlargement or abnormal growth seen in the inf. lateral ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - no appreciable enlargement noted in the 3rd ventricle - lateral ventricle appears within normal size limits with no apparent enlargement	CN	We have the following subject's personal information: - The subject is a male of 71.8 years old. - Subject's current marrietal status is: married. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following subject's family history information: - Both of his parents are reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 14. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e2 with no e4 allele.
ADNI_128_S_0272_MR_MPR__GradWarp__B1_Correction__N3__Scaled_Br_20070820132351689_S31632_I69219	On a T1-weighted brain MRI we observed: For the subcortical structures: - no findings suggestive of atrophy are seen in the pallidum - thalamus appears within normal limits without apparent atrophy - hippocampus appears preserved, with no observable tissue loss - amygdala demonstrates a healthy morphology without signs of atrophy - putamen appears within normal limits without apparent atrophy - the caudate shows no notable changes suggestive of atrophy - no observable atrophic changes in the accumbens For the ventricles: - no findings suggestive of enlargement are seen in the 3rd ventricle - inf. lateral ventricle appears within normal size limits with no apparent enlargement - no clear enlargement or abnormal growth seen in the lateral ventricle - 4th ventricle maintains a typical volume without observable enlargement - no findings suggestive of enlargement are seen in the external csf For the cerebral cortex: - occipital lobe demonstrates a healthy morphology without signs of atrophy - mild atrophy of the right insular cortex; the left insular cortex is normal - frontal lobe demonstrates a healthy morphology without signs of atrophy - no clear atrophic alterations are visible in the temporal lobe - no findings suggestive of atrophy are seen in the limbic cortex - no appreciable degenerative or atrophic changes observed in the parietal lobe	CN	We have the following subject's personal information: - The subject is a female of 71.5 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - The subject has a Boston Naming Test (BNT) total score of 30. - On the semantic categorical fluency test, the subject named 39 animals in 60 seconds. She named 23 vegetables in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 16. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Digit Span test of the Wechsler Memory Scale-Revised, her digit span forward length is 8, her digit span forward trials correct is 12, her digit span backward length is 7., her digit span forward trials correct is 11. - On the Trail Making Test Part A, her total number of seconds to complete is 19. On the Trail Making Test Part B, her total number of seconds to complete is 47. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in anxiety, irritability or lability, nighttime behaviors. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_021_S_7062_MR_Accelerated_Sag_IR-FSPGR_br_raw_20220329141636127_9_S1118228_I1561601	On a T1-weighted brain MRI we observed: For the cerebral cortex: - insular cortex appears within normal limits without apparent atrophy - mild atrophy of the left limbic cortex; normal-to-mild atrophy of the right limbic cortex; focal volume loss observed in the following subregions: posterior cingulate gyrus (mild atrophy on the left) - no observable atrophic changes in the temporal lobe - occipital lobe maintains a normal appearance with no observable atrophic features - parietal lobe demonstrates a healthy morphology without signs of atrophy - frontal lobe demonstrates a healthy morphology without signs of atrophy For the subcortical structures: - mild-to-moderate bilateral atrophy of the thalamus - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - mild bilateral atrophy of the putamen - no evident atrophy or tissue thinning seen in the caudate - no findings suggestive of atrophy are seen in the accumbens - amygdala maintains a normal appearance with no observable atrophic features - mild bilateral atrophy of the pallidum For the ventricles: - no findings suggestive of enlargement are seen in the 3rd ventricle - no findings suggestive of enlargement are seen in the inf. lateral ventricle - no observable enlargement of the 4th ventricle - no findings suggestive of enlargement are seen in the external csf - moderate enlargement of the left lateral ventricle and mild enlargement of the right lateral ventricle	CN	We have the following subject's personal information: - The subject is a female of 69.5 years old. - Subject's current marrietal status is: widowed. - She has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 17. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
FTLD_203198743_03349_MR_Accelerated_Sagittal_IR-FSPGR_br_raw_202_I11047395	On a T1-weighted brain MRI we observed: For the ventricles: - no appreciable enlargement noted in the external csf - no clear enlargement or abnormal growth seen in the inf. lateral ventricle - 4th ventricle maintains its expected proportions without signs of enlargement - no findings suggestive of enlargement are seen in the lateral ventricle - no appreciable enlargement noted in the 3rd ventricle For the cerebral cortex: - occipital lobe maintains a normal appearance with no observable atrophic features - insular cortex maintains a normal appearance with no observable atrophic features - limbic cortex appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the temporal lobe - no clear atrophic alterations are visible in the frontal lobe - no clear atrophic alterations are visible in the parietal lobe For the subcortical structures: - no clear atrophic alterations are visible in the pallidum - the thalamus shows no notable changes suggestive of atrophy - no appreciable degenerative or atrophic changes observed in the caudate - the amygdala shows no notable changes suggestive of atrophy - hippocampus demonstrates a healthy morphology without signs of atrophy - putamen demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the accumbens	BV	We have the following subject's personal information: - The subject is a male of 51.0 years old. - He has 16.0 years of education (equivalent to bachelor’s degree) - The subject is left-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 27 animals in 60 seconds. He named 11 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 32. - On the Number Span forward test, his longest span forward was 9. On the Number Span backward test, his longest span backward was 8. - On the Trail Making Test Part A, his total number of seconds to complete is 21, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 33, his number of commission errors is 0, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in apathy or indifference, irritability or lability, appetite and eating, a moderate (significant, but not dramatic) change in agitation or aggression, a mild (noticeable, but not significant) change in depression or dysphoria, disinhibition. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 3.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 0.5 (questionnable impairment). Description: Consistent mild word-finding difficulties; simplification of word choice; circumlocution; decreased phrase length; and/or mild comprehension difficulties.
ADNI_041_S_6447_MR_Accelerated_Sagittal_MPRAGE__br_raw_20180912155227554_149_S726646_I1047860	On a T1-weighted brain MRI we observed: For the cerebral cortex: - parietal lobe appears within normal limits without apparent atrophy - mild atrophy of the right temporal lobe; normal-to-mild atrophy of the left temporal lobe; focal volume loss observed in the following subregions: inf. temporal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) and middle temporal gyrus (normal on the left and mild-to-moderate atrophy on the right) - no findings suggestive of atrophy are seen in the frontal lobe - no appreciable degenerative or atrophic changes observed in the limbic cortex - no clear atrophic alterations are visible in the insular cortex - no observable atrophic changes in the occipital lobe For the ventricles: - no clear enlargement or abnormal growth seen in the lateral ventricle - no findings suggestive of enlargement are seen in the 3rd ventricle - no observable enlargement of the inf. lateral ventricle - external csf appears within normal size limits with no apparent enlargement - 4th ventricle appears within normal size limits with no apparent enlargement For the subcortical structures: - no evident atrophy or tissue thinning seen in the putamen - no evident atrophy or tissue thinning seen in the amygdala - no observable atrophic changes in the thalamus - no clear atrophic alterations are visible in the pallidum - accumbens demonstrates a healthy morphology without signs of atrophy - no clear atrophic alterations are visible in the caudate - normal-to-mild atrophy of the left hippocampus	CN	We have the following subject's personal information: - The subject is a female of 71.2 years old. - Subject's current marrietal status is: married. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following subject's family history information: - Her mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 14. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
NIFD_1_S_0180_MR_T1_mprage_S3_DIS3D_br_raw_20140831181136534_50_S229067_I441385	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no findings suggestive of atrophy are seen in the frontal lobe - no clear atrophic alterations are visible in the parietal lobe - insular cortex appears preserved, with no observable tissue loss - mild atrophy of the right limbic cortex; normal-to-mild atrophy of the left limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (normal on the left and mild atrophy on the right) and parahippocampal gyrus (normal on the left and mild atrophy on the right) - no appreciable degenerative or atrophic changes observed in the occipital lobe - no findings suggestive of atrophy are seen in the temporal lobe For the ventricles: - 3rd ventricle appears within normal size limits with no apparent enlargement - inf. lateral ventricle maintains a typical volume without observable enlargement - no clear enlargement or abnormal growth seen in the 4th ventricle - no evident size increase noted in the external csf - lateral ventricle maintains a typical volume without observable enlargement For the subcortical structures: - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - putamen appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the caudate - no appreciable degenerative or atrophic changes observed in the amygdala - pallidum maintains a normal appearance with no observable atrophic features - accumbens appears within normal limits without apparent atrophy - thalamus demonstrates a healthy morphology without signs of atrophy	CN	We have the following subject's personal information: - The subject is a male of 53.0 years old. - He has 18.0 years of education (equivalent to master’s degree) We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 27. - The subject has a Montreal Cognitive Assessment (MoCA) total score, corrected for education, of 24. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2.
ADNI_035_S_10721_MR_Accelerated_Sagittal_MPRAGE_MSV21_br_raw_20250513191854089_1_I11263014	On a T1-weighted brain MRI we observed: For the subcortical structures: - no findings suggestive of atrophy are seen in the caudate - no clear atrophic alterations are visible in the amygdala - thalamus appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the putamen - pallidum maintains a normal appearance with no observable atrophic features - no observable atrophic changes in the accumbens - no appreciable degenerative or atrophic changes observed in the hippocampus For the cerebral cortex: - limbic cortex appears within normal limits without apparent atrophy - occipital lobe appears preserved, with no observable tissue loss - no clear atrophic alterations are visible in the frontal lobe - parietal lobe maintains a normal appearance with no observable atrophic features - insular cortex demonstrates a healthy morphology without signs of atrophy - no appreciable degenerative or atrophic changes observed in the temporal lobe For the ventricles: - no appreciable enlargement noted in the 4th ventricle - no evident size increase noted in the lateral ventricle - no observable enlargement of the inf. lateral ventricle - no appreciable enlargement noted in the external csf - no clear enlargement or abnormal growth seen in the 3rd ventricle	CN	We have the following subject's personal information: - The subject is a female of 55.4 years old. - Subject's current marrietal status is: married. - She has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following subject's family history information: - Her mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 16. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care.
FTLD_203613082_03281_MR_Accelerated_Sagittal_MPRAGE_(MSV21)_br_r_I10450455	On a T1-weighted brain MRI we observed: For the subcortical structures: - no findings suggestive of atrophy are seen in the amygdala - no clear atrophic alterations are visible in the pallidum - caudate appears within normal limits without apparent atrophy - putamen demonstrates a healthy morphology without signs of atrophy - hippocampus demonstrates a healthy morphology without signs of atrophy - thalamus appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the accumbens For the ventricles: - no clear enlargement or abnormal growth seen in the 3rd ventricle - no findings suggestive of enlargement are seen in the inf. lateral ventricle - lateral ventricle maintains its expected proportions without signs of enlargement - no appreciable enlargement noted in the external csf - no evident size increase noted in the 4th ventricle For the cerebral cortex: - no appreciable degenerative or atrophic changes observed in the occipital lobe - no observable atrophic changes in the frontal lobe - parietal lobe maintains a normal appearance with no observable atrophic features - no appreciable degenerative or atrophic changes observed in the limbic cortex - temporal lobe appears within normal limits without apparent atrophy - mild bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: frontal operculum (mild atrophy on the left and normal on the right) and central operculum (mild atrophy on the right)	BV	We have the following subject's personal information: - The subject is a male of 70.0 years old. - He has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 25 animals in 60 seconds. He named 19 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 18. - On the Number Span forward test, his longest span forward was 5. On the Number Span backward test, his longest span backward was 5. - On the Trail Making Test Part A, his total number of seconds to complete is 23, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 93, his number of commission errors is 2, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in depression or dysphoria, disinhibition, irritability or lability, motor disturbance, appetite and eating. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 2.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 0.5 (questionnable impairment). Description: Consistent mild word-finding difficulties; simplification of word choice; circumlocution; decreased phrase length; and/or mild comprehension difficulties.
ADNI_128_S_0272_MR_MPR__GradWarp__B1_Correction__N3__Scaled_Br_20070820132351689_S31632_I69219	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no clear atrophic alterations are visible in the temporal lobe - limbic cortex appears preserved, with no observable tissue loss - the frontal lobe shows no notable changes suggestive of atrophy - the parietal lobe shows no notable changes suggestive of atrophy - mild atrophy of the right insular cortex; the left insular cortex is normal - occipital lobe appears within normal limits without apparent atrophy For the subcortical structures: - no findings suggestive of atrophy are seen in the putamen - the hippocampus shows no notable changes suggestive of atrophy - the amygdala shows no notable changes suggestive of atrophy - the thalamus shows no notable changes suggestive of atrophy - no evident atrophy or tissue thinning seen in the accumbens - pallidum appears preserved, with no observable tissue loss - caudate appears within normal limits without apparent atrophy For the ventricles: - the 3rd ventricle shows no notable changes suggestive of enlargement - lateral ventricle maintains its expected proportions without signs of enlargement - no findings suggestive of enlargement are seen in the external csf - inf. lateral ventricle maintains a typical volume without observable enlargement - no appreciable enlargement noted in the 4th ventricle	CN	We have the following subject's personal information: - The subject is a female of 71.5 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - The subject has a Boston Naming Test (BNT) total score of 30. - On the semantic categorical fluency test, the subject named 39 animals in 60 seconds. She named 23 vegetables in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 16. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Digit Span test of the Wechsler Memory Scale-Revised, her digit span forward length is 8, her digit span forward trials correct is 12, her digit span backward length is 7., her digit span forward trials correct is 11. - On the Trail Making Test Part A, her total number of seconds to complete is 19. On the Trail Making Test Part B, her total number of seconds to complete is 47. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in anxiety, irritability or lability, nighttime behaviors. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_023_S_0887_MR_MPR-R__GradWarp__B1_Correction__N3__Scaled_Br_20100106093143264_S75830_I162314	On a T1-weighted brain MRI we observed: For the ventricles: - mild-to-moderate enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle - no findings suggestive of enlargement are seen in the 3rd ventricle - mild bilateral enlargement of the lateral ventricle - no evident size increase noted in the 4th ventricle - no clear enlargement or abnormal growth seen in the external csf For the subcortical structures: - mild bilateral atrophy of the caudate - no findings suggestive of atrophy are seen in the putamen - mild bilateral atrophy of the accumbens - moderate atrophy of the left amygdala and mild-to-moderate atrophy of the right amygdala - no clear atrophic alterations are visible in the pallidum - no findings suggestive of atrophy are seen in the thalamus - moderate atrophy of the left hippocampus, moderate atrophy of the right hippocampus For the cerebral cortex: - parietal lobe demonstrates a healthy morphology without signs of atrophy - no observable atrophic changes in the occipital lobe - limbic cortex demonstrates a healthy morphology without signs of atrophy - insular cortex appears preserved, with no observable tissue loss - no clear atrophic alterations are visible in the frontal lobe - mild atrophy of the left temporal lobe; normal-to-mild atrophy of the right temporal lobe; focal volume loss observed in the following subregions: temporal pole (mild atrophy both left and right)	AD	We have the following subject's personal information: - The subject is a female of 76.8 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 12. In her MMSE test, she has an orientation to time score of 0. In her MMSE test, she has an orientation to place score of 3.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - The subject has a Boston Naming Test (BNT) total score of 12. - On the semantic categorical fluency test, the subject named 9 animals in 60 seconds. She named 10 vegetables in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 0. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for shopping alone for clothes, household necessities, or groceries, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal. The subject has difficulity, but does by himself, for assembling tax records, business affairs, or other paper, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject requires assitance for writing checks, paying bills, or balancing a checkbook, for playing a game of skill such as bridge or chess, working on a hobby, for remembering appointments, family occasions, holidays, medications. - On the Digit Span test of the Wechsler Memory Scale-Revised, her digit span forward length is 4, her digit span forward trials correct is 4, her digit span backward length is 2., her digit span forward trials correct is 1. - On the Trail Making Test Part A, her total number of seconds to complete is 77. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in delusions, motor disturbance. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 5.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 2.0 (moderate impairment). Description: Severe difficulty with time relationships; usually disoriented to time, often to place. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
FTLD_203297245_03549_MR_Accelerated_Sagittal_MPRAGE_br_raw_20240_I10450917	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild-to-moderate bilateral atrophy of the caudate - no findings suggestive of atrophy are seen in the pallidum - moderate bilateral atrophy of the amygdala - mild-to-moderate atrophy of the left putamen; normal-to-mild atrophy of the right putamen - thalamus demonstrates a healthy morphology without signs of atrophy - mild-to-moderate atrophy of the left hippocampus, mild atrophy of the right hippocampus - mild-to-moderate bilateral atrophy of the accumbens For the cerebral cortex: - mild bilateral atrophy of the parietal lobe; focal volume loss observed in the following subregions: sup. parietal lobule (normal-to-mild atrophy on the left and mild atrophy on the right) and precuneus (mild atrophy on the left and normal on the right) - the insular cortex shows no notable changes suggestive of atrophy - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild atrophy both left and right), entorhinal area (normal-to-mild atrophy on the left and mild atrophy on the right) and parahippocampal gyrus (normal on the left and mild atrophy on the right) - moderate atrophy of the left temporal lobe and mild atrophy of the right temporal lobe; focal volume loss observed in the following subregions: temporal pole (mild-to-moderate atrophy both left and right), fusiform gyrus (mild atrophy on the left and normal on the right), inf. temporal gyrus (mild atrophy on the left and normal on the right) and middle temporal gyrus (mild atrophy on the left and normal on the right) - mild bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: middle frontal gyrus (mild atrophy both left and right), anterior orbital gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) and precentral gyrus (mild atrophy on the left and normal on the right) - occipital lobe appears preserved, with no observable tissue loss For the ventricles: - mild-to-moderate enlargement of the external csf - mild-to-moderate enlargement of the left lateral ventricle and mild enlargement of the right lateral ventricle - moderate-to-severe enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle - mild enlargement of the 3rd ventricle - mild enlargement of the 4th ventricle	BV	We have the following subject's personal information: - The subject is a male of 85.0 years old. - He has 17.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 19. - On the semantic categorical fluency test, the subject named 9 animals in 60 seconds. He named 6 vegetables in 60 seconds. - On the Number Span forward test, his longest span forward was 7. On the Number Span backward test, his longest span backward was 3. - On the Trail Making Test Part A, his total number of seconds to complete is 51, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 300, his number of commission errors is 9, his number of correct lines is 16. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in disinhibition, appetite and eating, a mild (noticeable, but not significant) change in depression or dysphoria, anxiety, apathy or indifference. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 3.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. * Behavior, comportment, and personality: Score 0.5 (questionnable impairment). Description: Questionable changes in comportment, empathy, appropriateness of actions. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
NIFD_1_S_0150_MR_T1_mprage_S3_DIS3D_br_raw_20140612230525878_108_S222089_I430659	On a T1-weighted brain MRI we observed: For the ventricles: - 3rd ventricle appears within normal size limits with no apparent enlargement - no findings suggestive of enlargement are seen in the external csf - 4th ventricle maintains its expected proportions without signs of enlargement - no findings suggestive of enlargement are seen in the inf. lateral ventricle - lateral ventricle appears within normal size limits with no apparent enlargement For the cerebral cortex: - limbic cortex appears preserved, with no observable tissue loss - no evident atrophy or tissue thinning seen in the insular cortex - no findings suggestive of atrophy are seen in the parietal lobe - the temporal lobe shows no notable changes suggestive of atrophy - no observable atrophic changes in the frontal lobe - occipital lobe appears preserved, with no observable tissue loss For the subcortical structures: - amygdala demonstrates a healthy morphology without signs of atrophy - accumbens appears preserved, with no observable tissue loss - the thalamus shows no notable changes suggestive of atrophy - pallidum demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the hippocampus - the caudate shows no notable changes suggestive of atrophy - the putamen shows no notable changes suggestive of atrophy	CN	We have the following subject's personal information: - The subject is a female of 58.0 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. - The subject has a Montreal Cognitive Assessment (MoCA) total score, corrected for education, of 28. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0.
ADNI_116_S_6100_MR_Accelerated_Sagittal_MPRAGE__br_raw_20181220100406092_10_S763123_I1092329	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no observable atrophic changes in the parietal lobe - frontal lobe demonstrates a healthy morphology without signs of atrophy - no appreciable degenerative or atrophic changes observed in the occipital lobe - mild atrophy of the left insular cortex; normal-to-mild atrophy of the right insular cortex; focal volume loss observed in the following subregions: anterior insula (normal-to-mild atrophy on the left and mild atrophy on the right) and posterior insula (mild atrophy on the left and normal on the right) - mild atrophy of the left temporal lobe; normal-to-mild atrophy of the right temporal lobe; focal volume loss observed in the following subregions: temporal pole (mild atrophy on the left and normal-to-mild atrophy on the right) and inf. temporal gyrus (mild atrophy on the left) - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: entorhinal area (mild-to-moderate atrophy both left and right), parahippocampal gyrus (mild atrophy both left and right) and anterior cingulate gyrus (mild atrophy on the left and normal on the right) For the ventricles: - moderate enlargement of the left inf. lateral ventricle and severe enlargement of the right inf. lateral ventricle - external csf appears within normal size limits with no apparent enlargement - 3rd ventricle appears to be of normal dimensions, with no observable increase in size - mild bilateral enlargement of the lateral ventricle - 4th ventricle appears within normal size limits with no apparent enlargement For the subcortical structures: - moderate-to-severe bilateral atrophy of the amygdala - pallidum appears preserved, with no observable tissue loss - moderate atrophy of the left hippocampus, moderate atrophy of the right hippocampus - the accumbens shows no notable changes suggestive of atrophy - no appreciable degenerative or atrophic changes observed in the caudate - no clear atrophic alterations are visible in the thalamus - putamen appears within normal limits without apparent atrophy	AD	We have the following subject's personal information: - The subject is a female of 71.3 years old. - Subject's current marrietal status is: widowed. - She has 13.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 18. In her MMSE test, she has an orientation to time score of 3. In her MMSE test, she has an orientation to place score of 2.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 0. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 8.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 2.0 (moderate impairment). Description: No pretense of independent function outside the home; appears well enough to be taken to functions outside the family home. * Home and hobbies: Score 2.0 (moderate impairment). Description: Only simple chores preserved; very restricted interests, poorly maintained. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. From genetic data, APOE genotype is e4,e4 with 2 copies of e4 allele.
ADNI_116_S_10365_MR_Accelerated_Sagittal_MPRAGE_MSV21_br_raw_20241222190222910_1_I11081279	On a T1-weighted brain MRI we observed: For the subcortical structures: - hippocampus appears preserved, with no observable tissue loss - no clear atrophic alterations are visible in the amygdala - the thalamus shows no notable changes suggestive of atrophy - no evident atrophy or tissue thinning seen in the putamen - the caudate shows no notable changes suggestive of atrophy - the accumbens shows no notable changes suggestive of atrophy - no observable atrophic changes in the pallidum For the ventricles: - no observable enlargement of the 3rd ventricle - no findings suggestive of enlargement are seen in the 4th ventricle - no findings suggestive of enlargement are seen in the lateral ventricle - no clear enlargement or abnormal growth seen in the inf. lateral ventricle - no clear enlargement or abnormal growth seen in the external csf For the cerebral cortex: - frontal lobe appears within normal limits without apparent atrophy - parietal lobe appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the occipital lobe - no findings suggestive of atrophy are seen in the insular cortex - no appreciable degenerative or atrophic changes observed in the temporal lobe - limbic cortex maintains a normal appearance with no observable atrophic features	CN	We have the following subject's personal information: - The subject is a female of 69.5 years old. - Subject's current marrietal status is: never married. - She has 20.0 years of education (equivalent to doctorate) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 28. In her MMSE test, she has an orientation to time score of 4. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 3. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 10. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e2 with no e4 allele.
FTLD_203473974_03477_MR_Accelerated_Sagittal_MPRAGE_br_raw_20240_I10450828	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild bilateral atrophy of the accumbens - moderate atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus - severe atrophy of the left amygdala and moderate-to-severe atrophy of the right amygdala - thalamus appears preserved, with no observable tissue loss - mild-to-moderate atrophy of the left putamen and mild atrophy of the right putamen - mild-to-moderate atrophy of the left pallidum and mild atrophy of the right pallidum - mild-to-moderate atrophy of the left caudate; normal-to-mild atrophy of the right caudate For the cerebral cortex: - moderate-to-severe atrophy of the left temporal lobe and mild-to-moderate atrophy of the right temporal lobe; focal volume loss observed in the following subregions: temporal pole (moderate atrophy on the left and mild-to-moderate atrophy on the right), fusiform gyrus (mild-to-moderate atrophy both left and right), inf. temporal gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), middle temporal gyrus (mild atrophy on the left and normal on the right) and planum temporale (mild atrophy on the left and normal on the right) - mild-to-moderate atrophy of the left insular cortex; normal-to-mild atrophy of the right insular cortex; focal volume loss observed in the following subregions: anterior insula (mild-to-moderate atrophy on the left and mild atrophy on the right) and posterior insula (mild atrophy both left and right) - parietal lobe appears within normal limits without apparent atrophy - limbic cortex appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the frontal lobe - occipital lobe maintains a normal appearance with no observable atrophic features For the ventricles: - mild-to-moderate enlargement of the left lateral ventricle and mild enlargement of the right lateral ventricle - no observable enlargement of the 4th ventricle - severe enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle - mild enlargement of the 3rd ventricle - mild enlargement of the external csf	SV	We have the following subject's personal information: - The subject is a male of 66.0 years old. - He has 20.0 years of education (equivalent to doctorate) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 0. - On the semantic categorical fluency test, the subject named 1 animals in 60 seconds. He named 1 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 0. - On the Number Span forward test, his longest span forward was 8. On the Number Span backward test, his longest span backward was 4. - On the Trail Making Test Part A, his total number of seconds to complete is 104, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 198, his number of commission errors is 0, his number of correct lines is 24. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. His standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.5 (questionnable impairment). Description: Questionable changes in comportment, empathy, appropriateness of actions. * Language: Score 1.0 (mild impairment). Description: Moderate word-finding difficulty in speech; cannot name objects in environment; reduced phrase length and/or agrammatical speech and/or reduced comprehension in conversation and reading.
FTLD_203163034_02436_MR_Sagittal_MP-Rage_br_raw_20230209101942649_I10183429	On a T1-weighted brain MRI we observed: For the subcortical structures: - no clear atrophic alterations are visible in the hippocampus - mild atrophy of the left accumbens; the right accumbens is normal - mild atrophy of the left amygdala; the right amygdala is normal - thalamus maintains a normal appearance with no observable atrophic features - mild atrophy of the left pallidum; normal-to-mild atrophy of the right pallidum - mild atrophy of the left caudate; the right caudate is normal - mild atrophy of the left putamen; the right putamen is normal For the cerebral cortex: - no evident atrophy or tissue thinning seen in the temporal lobe - no findings suggestive of atrophy are seen in the insular cortex - no observable atrophic changes in the occipital lobe - parietal lobe appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the limbic cortex - mild atrophy of the left frontal lobe; the right frontal lobe is normal; focal volume loss observed in the following subregions: opercular inf. frontal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), supplementary motor cortex (mild atrophy on the left and normal on the right) and gyrus rectus (mild atrophy on the left and normal on the right) For the ventricles: - mild-to-moderate enlargement of the external csf - the 3rd ventricle shows no notable changes suggestive of enlargement - inf. lateral ventricle appears within normal size limits with no apparent enlargement - 4th ventricle appears to be of normal dimensions, with no observable increase in size - no clear enlargement or abnormal growth seen in the lateral ventricle	PNFA	We have the following subject's personal information: - The subject is a male of 66.0 years old. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 11 animals in 60 seconds. He named 7 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 12. - On the Number Span forward test, his longest span forward was 4. On the Number Span backward test, his longest span backward was 3. - On the Trail Making Test Part A, his total number of seconds to complete is 51, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 235, his number of commission errors is 1, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in nighttime behaviors, appetite and eating, a moderate (significant, but not dramatic) change in agitation or aggression, apathy or indifference, motor disturbance, a mild (noticeable, but not significant) change in hallucinations. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 2.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
ADNI_016_S_6971_MR_Accelerated_Sagittal_MPRAGE__br_raw_20210622084513280_27_S1035971_I1458511	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no clear atrophic alterations are visible in the insular cortex - parietal lobe appears within normal limits without apparent atrophy - the temporal lobe shows no notable changes suggestive of atrophy - occipital lobe appears preserved, with no observable tissue loss - frontal lobe demonstrates a healthy morphology without signs of atrophy - no observable atrophic changes in the limbic cortex For the subcortical structures: - the pallidum shows no notable changes suggestive of atrophy - thalamus appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the caudate - no clear atrophic alterations are visible in the hippocampus - mild atrophy of the left amygdala; the right amygdala is normal - no evident atrophy or tissue thinning seen in the accumbens - no findings suggestive of atrophy are seen in the putamen For the ventricles: - 3rd ventricle appears to be of normal dimensions, with no observable increase in size - external csf appears within normal size limits with no apparent enlargement - mild bilateral enlargement of the inf. lateral ventricle - the 4th ventricle shows no notable changes suggestive of enlargement - no appreciable enlargement noted in the lateral ventricle	CN	We have the following subject's personal information: - The subject is a male of 72.7 years old. - Subject's current marrietal status is: married. - He has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 9. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_006_S_4192_MR_MPRAGE_br_raw_20110928083832513_147_S123807_I258594	On a T1-weighted brain MRI we observed: For the subcortical structures: - caudate appears within normal limits without apparent atrophy - normal-to-mild atrophy of the left hippocampus, normal-to-mild atrophy of the right hippocampus - no clear atrophic alterations are visible in the accumbens - no findings suggestive of atrophy are seen in the thalamus - pallidum appears preserved, with no observable tissue loss - mild atrophy of the right putamen; the left putamen is normal - moderate atrophy of the left amygdala and mild-to-moderate atrophy of the right amygdala For the cerebral cortex: - temporal lobe appears within normal limits without apparent atrophy - frontal lobe appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the limbic cortex - insular cortex appears preserved, with no observable tissue loss - parietal lobe maintains a normal appearance with no observable atrophic features - occipital lobe demonstrates a healthy morphology without signs of atrophy For the ventricles: - 3rd ventricle appears to be of normal dimensions, with no observable increase in size - moderate enlargement of the left inf. lateral ventricle and severe enlargement of the right inf. lateral ventricle - moderate bilateral enlargement of the lateral ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - no findings suggestive of enlargement are seen in the external csf	AD	We have the following subject's personal information: - The subject is a male of 82.4 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 29. - On the semantic categorical fluency test, the subject named 17 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject has difficulity, but does by himself, for shopping alone for clothes, household necessities, or groceries, for paying attention to and understanding a TV program, book, or magazine. The subject requires assitance for remembering appointments, family occasions, holidays, medications. - On the Trail Making Test Part A, his total number of seconds to complete is 52. On the Trail Making Test Part B, his total number of seconds to complete is 90. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_131_S_6805_MR_Sagittal_3D_Accelerated_MPRAGE_br_raw_20211213150617188_103_S1089961_I1525978	On a T1-weighted brain MRI we observed: For the cerebral cortex: - mild atrophy of the right insular cortex; the left insular cortex is normal; focal volume loss observed in the following subregions: parietal operculum (mild atrophy on the left and mild-to-moderate atrophy on the right) and frontal operculum (normal on the left and mild atrophy on the right) - no observable atrophic changes in the frontal lobe - mild atrophy of the left temporal lobe and mild-to-moderate atrophy of the right temporal lobe; focal volume loss observed in the following subregions: planum temporale (mild-to-moderate atrophy on the left and mild atrophy on the right), middle temporal gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right) and inf. temporal gyrus (normal on the left and mild atrophy on the right) - mild atrophy of the left parietal lobe and mild-to-moderate atrophy of the right parietal lobe; focal volume loss observed in the following subregions: sup. parietal lobule (mild atrophy both left and right), precuneus (normal on the left and mild-to-moderate atrophy on the right) and angular gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) - mild atrophy of the left occipital lobe and mild-to-moderate atrophy of the right occipital lobe; focal volume loss observed in the following subregions: calcarine cortex (mild atrophy both left and right), cuneus (normal-to-mild atrophy on the left and mild atrophy on the right), middle occipital gyrus (mild-to-moderate atrophy on the left and normal on the right), inf. occipital gyrus (normal on the left and mild atrophy on the right) and sup. occipital gyrus (mild atrophy on the right) - mild-to-moderate atrophy of the right limbic cortex; normal-to-mild atrophy of the left limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right), middle cingulate gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) and posterior cingulate gyrus (normal on the left and mild atrophy on the right) For the ventricles: - mild enlargement of the 3rd ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - mild enlargement of the external csf - severe bilateral enlargement of the lateral ventricle - moderate enlargement of the left inf. lateral ventricle and severe enlargement of the right inf. lateral ventricle For the subcortical structures: - mild atrophy of the right amygdala; the left amygdala is normal - no findings suggestive of atrophy are seen in the pallidum - accumbens maintains a normal appearance with no observable atrophic features - no findings suggestive of atrophy are seen in the thalamus - mild atrophy of the left putamen and moderate atrophy of the right putamen - mild atrophy of the right hippocampus - mild atrophy of the right caudate; normal-to-mild atrophy of the left caudate	AD	We have the following subject's personal information: - The subject is a female of 64.1 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 28. In her MMSE test, she has an orientation to time score of 4. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 3. - The subject has a 32-item Multilingual Naming Test (MINT) total score of 20. - On the semantic categorical fluency test, the subject named 15 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 15. - On the Functional Activities Questionnaire (FAQ), the subject requires assitance for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject is dependent for heating water, making a cup of coffee, turning off the stove. - On the Trail Making Test Part A, her total number of seconds to complete is 150. On the Trail Making Test Part B, her total number of seconds to complete is 300. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. Her standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 2.0 (moderate impairment). Description: Requires much help with personal care; frequent incontinence. From genetic data, APOE genotype is e3,e3 with no e4 allele.
NIFD_1_S_0018_MR_t1_mprage__br_raw_20170814165807711_159_S594325_I886781	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no observable atrophic changes in the occipital lobe - no appreciable degenerative or atrophic changes observed in the parietal lobe - moderate bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: inf. temporal gyrus (mild-to-moderate atrophy on the left and moderate atrophy on the right), middle temporal gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), temporal pole (mild-to-moderate atrophy on the left and mild atrophy on the right) and fusiform gyrus (mild atrophy on the right) - no evident atrophy or tissue thinning seen in the frontal lobe - no clear atrophic alterations are visible in the insular cortex - mild atrophy of the left limbic cortex; the right limbic cortex is normal; focal volume loss observed in the following subregions: entorhinal area (mild atrophy on the left and normal-to-mild atrophy on the right) and anterior cingulate gyrus (mild atrophy on the left and normal on the right) For the ventricles: - moderate bilateral enlargement of the inf. lateral ventricle - no evident size increase noted in the 3rd ventricle - no observable enlargement of the 4th ventricle - no observable enlargement of the lateral ventricle - moderate enlargement of the external csf For the subcortical structures: - mild atrophy of the left accumbens and mild-to-moderate atrophy of the right accumbens - mild atrophy of the left thalamus and mild-to-moderate atrophy of the right thalamus - pallidum maintains a normal appearance with no observable atrophic features - no appreciable degenerative or atrophic changes observed in the putamen - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - mild atrophy of the left caudate; the right caudate is normal - severe atrophy of the left amygdala and moderate-to-severe atrophy of the right amygdala	BV	We have the following subject's personal information: - The subject is a male of 71.0 years old. - He has 8.0 years of education We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 16. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for playing a game of skill such as bridge or chess, working on a hobby. The subject has difficulity, but does by himself, for heating water, making a cup of coffee, turning off the stove, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications. The subject requires assitance for preparing a balanced meal. The subject is dependent for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for traveling out of the neighborhood, driving, or arranging to take public transportation. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in apathy or indifference, a moderate (significant, but not dramatic) change in appetite and eating, a mild (noticeable, but not significant) change in elation or euphoria, motor disturbance. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. His standard CDR Sum of Boxes score is 8.0. --- ## 📋 Detailed Domain Scores * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_073_S_5227_MR_MPRAGE_br_raw_20130619102207359_101_S192788_I377325	On a T1-weighted brain MRI we observed: For the cerebral cortex: - occipital lobe demonstrates a healthy morphology without signs of atrophy - no observable atrophic changes in the parietal lobe - no appreciable degenerative or atrophic changes observed in the frontal lobe - no clear atrophic alterations are visible in the limbic cortex - mild atrophy of the left temporal lobe; normal-to-mild atrophy of the right temporal lobe; focal volume loss observed in the following subregions: inf. temporal gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), middle temporal gyrus (mild atrophy both left and right) and planum polare (mild atrophy on the left and normal on the right) - no findings suggestive of atrophy are seen in the insular cortex For the ventricles: - lateral ventricle appears within normal size limits with no apparent enlargement - external csf appears within normal size limits with no apparent enlargement - no findings suggestive of enlargement are seen in the 3rd ventricle - no findings suggestive of enlargement are seen in the 4th ventricle - inf. lateral ventricle appears to be of normal dimensions, with no observable increase in size For the subcortical structures: - pallidum demonstrates a healthy morphology without signs of atrophy - putamen appears within normal limits without apparent atrophy - no observable atrophic changes in the accumbens - no clear atrophic alterations are visible in the caudate - no evident atrophy or tissue thinning seen in the amygdala - thalamus appears within normal limits without apparent atrophy - hippocampus appears preserved, with no observable tissue loss	CN	We have the following subject's personal information: - The subject is a male of 71.3 years old. - Subject's current marrietal status is: married. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following subject's health history information: - He has quit smoking at the age of 37.He smoked one cigarette to half a pack a day. - He has a remote/inactive history of alcool abuse. - He has a remote/inactive history of substance abuse (drug). We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 5. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 10. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_007_S_5196_MR_Accelerated_SAG_IR-SPGR__br_raw_20130612130338802_16_S192134_I376238	On a T1-weighted brain MRI we observed: For the ventricles: - inf. lateral ventricle appears to be of normal dimensions, with no observable increase in size - lateral ventricle appears to be of normal dimensions, with no observable increase in size - the 3rd ventricle shows no notable changes suggestive of enlargement - mild enlargement of the external csf - 4th ventricle appears within normal size limits with no apparent enlargement For the subcortical structures: - mild-to-moderate atrophy of the left amygdala and moderate atrophy of the right amygdala - the putamen shows no notable changes suggestive of atrophy - mild atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus - no clear atrophic alterations are visible in the pallidum - caudate demonstrates a healthy morphology without signs of atrophy - no appreciable degenerative or atrophic changes observed in the accumbens - no appreciable degenerative or atrophic changes observed in the thalamus For the cerebral cortex: - mild atrophy of the right occipital lobe; the left occipital lobe is normal - temporal lobe appears within normal limits without apparent atrophy - limbic cortex maintains a normal appearance with no observable atrophic features - insular cortex appears preserved, with no observable tissue loss - frontal lobe appears within normal limits without apparent atrophy - parietal lobe demonstrates a healthy morphology without signs of atrophy	AD	We have the following subject's personal information: - The subject is a female of 72.9 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 26. - On the semantic categorical fluency test, the subject named 18 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for keeping track of current events. The subject has difficulity, but does by himself, for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for preparing a balanced meal, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject requires assitance for remembering appointments, family occasions, holidays, medications. - On the Trail Making Test Part A, her total number of seconds to complete is 37. On the Trail Making Test Part B, her total number of seconds to complete is 96. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
NIFD_1_S_0012_MR_t1_mprage_S3_DIS3D_br_raw_20110203110049942_46_S98799_I215664	On a T1-weighted brain MRI we observed: For the cerebral cortex: - mild atrophy of the left temporal lobe; the right temporal lobe is normal; focal volume loss observed in the following subregions: sup. temporal gyrus (normal on the left and mild atrophy on the right) - the occipital lobe shows no notable changes suggestive of atrophy - mild-to-moderate atrophy of the left limbic cortex and mild atrophy of the right limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild-to-moderate atrophy both left and right), entorhinal area (mild atrophy on the left and normal-to-mild atrophy on the right), middle cingulate gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) and parahippocampal gyrus (mild atrophy on the left and normal on the right) - severe atrophy of the left insular cortex and moderate atrophy of the right insular cortex; focal volume loss observed in the following subregions: anterior insula (severe atrophy on the left and moderate-to-severe atrophy on the right), central operculum (mild-to-moderate atrophy both left and right), posterior insula (mild-to-moderate atrophy on the left and mild atrophy on the right), frontal operculum (mild atrophy both left and right) and parietal operculum (mild atrophy on the left and normal on the right) - mild atrophy of the left parietal lobe; the right parietal lobe is normal; focal volume loss observed in the following subregions: supramarginal gyrus (mild atrophy on the left and normal on the right) - severe atrophy of the left frontal lobe and moderate atrophy of the right frontal lobe; focal volume loss observed in the following subregions: medial orbital gyrus (moderate atrophy on the left and mild atrophy on the right), middle frontal gyrus (moderate atrophy on the left and mild atrophy on the right), gyrus rectus (mild atrophy both left and right), sup. frontal gyrus medial segment (mild atrophy both left and right), medial frontal cortex (mild atrophy both left and right), sup. frontal gyrus (mild atrophy both left and right), orbital inf. frontal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), posterior orbital gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), precentral gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), subcallosal area (mild atrophy on the left and normal-to-mild atrophy on the right), anterior orbital gyrus (mild atrophy on the left and normal on the right), precentral gyrus medial segment (mild atrophy on the left and normal on the right), supplementary motor cortex (mild atrophy on the left and normal on the right) and frontal pole (normal on the left and mild atrophy on the right) For the subcortical structures: - severe atrophy of the left amygdala and moderate atrophy of the right amygdala - moderate-to-severe atrophy of the left accumbens and moderate atrophy of the right accumbens - severe atrophy of the left putamen and moderate atrophy of the right putamen - mild atrophy of the left hippocampus, normal-to-mild atrophy of the right hippocampus - mild atrophy of the left thalamus; the right thalamus is normal - no findings suggestive of atrophy are seen in the pallidum - severe atrophy of the left caudate and moderate atrophy of the right caudate For the ventricles: - moderate bilateral enlargement of the inf. lateral ventricle - mild-to-moderate enlargement of the left lateral ventricle and mild enlargement of the right lateral ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - moderate-to-severe enlargement of the external csf - mild-to-moderate enlargement of the 3rd ventricle	PNFA	We have the following subject's personal information: - The subject is a male of 71.0 years old. - He has 19.0 years of education We have the following results on the Neuropsychological Test Battery: - On the Functional Activities Questionnaire (FAQ), the subject requires assitance for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine. The subject is dependent for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for preparing a balanced meal, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in apathy or indifference, motor disturbance, a mild (noticeable, but not significant) change in depression or dysphoria, anxiety. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 2.0, corresponding to moderate impairment. His standard CDR Sum of Boxes score is 10.0. --- ## 📋 Detailed Domain Scores * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 1.0 (mild impairment). Description: Moderate word-finding difficulty in speech; cannot name objects in environment; reduced phrase length and/or agrammatical speech and/or reduced comprehension in conversation and reading.
FTLD_203471184_02487_MR_Sagittal_MP-Rage_br_raw_20230206160932358_I10181553	On a T1-weighted brain MRI we observed: For the cerebral cortex: - limbic cortex demonstrates a healthy morphology without signs of atrophy - the insular cortex shows no notable changes suggestive of atrophy - the occipital lobe shows no notable changes suggestive of atrophy - temporal lobe maintains a normal appearance with no observable atrophic features - parietal lobe appears within normal limits without apparent atrophy - the frontal lobe does not exhibit generalized atrophy; localized volume reductions - with varying degrees of severity - are observed in middle frontal gyrus (moderate atrophy on the left and normal on the right), gyrus rectus (mild atrophy on the left and normal on the right) and supplementary motor cortex (mild atrophy on the left) For the ventricles: - no evident size increase noted in the 3rd ventricle - no appreciable enlargement noted in the inf. lateral ventricle - no clear enlargement or abnormal growth seen in the lateral ventricle - no clear enlargement or abnormal growth seen in the 4th ventricle - no observable enlargement of the external csf For the subcortical structures: - mild bilateral atrophy of the accumbens - no appreciable degenerative or atrophic changes observed in the amygdala - no clear atrophic alterations are visible in the thalamus - the hippocampus shows no notable changes suggestive of atrophy - mild atrophy of the right pallidum; the left pallidum is normal - putamen appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the caudate	CN	We have the following subject's personal information: - The subject is a female of 48.0 years old. - She has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 30. - On the semantic categorical fluency test, the subject named 26 animals in 60 seconds. She named 19 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 32. - On the Number Span forward test, her longest span forward was 6. On the Number Span backward test, her longest span backward was 6. - On the Trail Making Test Part A, her total number of seconds to complete is 15, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 34, her number of commission errors is 0, her number of correct lines is 24. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_127_S_2234_MR_Accelerated_Sag_IR-FSPGR_br_raw_20130125162820904_102_S180999_I356294	On a T1-weighted brain MRI we observed: For the subcortical structures: - no observable atrophic changes in the putamen - no appreciable degenerative or atrophic changes observed in the thalamus - caudate appears preserved, with no observable tissue loss - mild atrophy of the left accumbens; the right accumbens is normal - hippocampus appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the pallidum - mild atrophy of the left amygdala; the right amygdala is normal For the ventricles: - no evident size increase noted in the inf. lateral ventricle - no observable enlargement of the external csf - no appreciable enlargement noted in the lateral ventricle - no clear enlargement or abnormal growth seen in the 4th ventricle - 3rd ventricle appears within normal size limits with no apparent enlargement For the cerebral cortex: - no findings suggestive of atrophy are seen in the frontal lobe - the occipital lobe shows no notable changes suggestive of atrophy - no evident atrophy or tissue thinning seen in the parietal lobe - mild atrophy of the right limbic cortex; normal-to-mild atrophy of the left limbic cortex - the temporal lobe shows no notable changes suggestive of atrophy - no clear atrophic alterations are visible in the insular cortex	CN	We have the following subject's personal information: - The subject is a female of 65.8 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 28. In her MMSE test, she has an orientation to time score of 3. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - The subject has a Boston Naming Test (BNT) total score of 28. - On the semantic categorical fluency test, the subject named 25 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 15. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject has difficulity, but does by himself, for writing checks, paying bills, or balancing a checkbook. The subject requires assitance for assembling tax records, business affairs, or other paper, for remembering appointments, family occasions, holidays, medications. - On the Trail Making Test Part A, her total number of seconds to complete is 28. On the Trail Making Test Part B, her total number of seconds to complete is 58. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e2 with no e4 allele.

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