asafd60/LiLT_Processed · Datasets at Hugging Face

id string	words list	boxes list	question string	answer string
503	[ "DEPARTMENT", "OF", "HEALTH", "&", "HUMAN", "SERVICES", "Public", "Health", "Service", "Food", "and", "Drug", "Administration", "Rockville,", "MD", "20857", "NDA", "21-073/S-026", "DISCIPLINE", "REVIEW", "LETTER", "Takeda", "Global", "Research", "&", "Development", ...	[ [ 188, 91, 314, 106 ], [ 316, 91, 341, 107 ], [ 344, 91, 417, 107 ], [ 423, 91, 437, 107 ], [ 440, 91, 506, 107 ], [ 512, 91, 602, 107 ], [ 678, 85, 716, 97 ], [ 718, 8...	What kind of a letter is this ?	DISCIPLINE REVIEW LETTER
502	[ "Lilly", "Eli", "Lilly", "and", "Company", "Pharmaceutical", "Division", "Lilly", "Corporate", "Center", "Indianapolis,", "Indiana", "46285", "317.276.2090", "August", "16,", "1999", "Alan", "D.", "Mackenzie", "Senior", "Vice", "President,", "Sales", "and", "Marketi...	[ [ 483, 67, 540, 96 ], [ 404, 112, 429, 126 ], [ 432, 113, 471, 126 ], [ 475, 113, 509, 126 ], [ 515, 113, 605, 127 ], [ 431, 127, 526, 136 ], [ 528, 127, 574, 137 ], [ 436,...	Which two companies have agreed to amend the Co-Promotion Agreement?	Takeda Pharmaceuticals America, Inc. ("TPA") and Eli Lilly and Company ("Lilly")
504	[ "EXHIBIT", "Ant", "THE", "UPJOHN", "COMPANY", "KALAMAZOO.", "MICHIGAN", "49001", "0199.", "U.5.4.", "TELEPHONE:", "(616)", "323", "4000", "J.", "R.", "MITCHELL,", "MD.,", "P.", "D.", "Vice", "Chairman", "of", "the", "doand", "PAR.", "September", "21,", "1993",...	[ [ 463, 23, 544, 39 ], [ 767, 82, 832, 108 ], [ 190, 126, 264, 152 ], [ 287, 127, 452, 153 ], [ 477, 124, 698, 153 ], [ 188, 156, 262, 168 ], [ 265, 158, 319, 169 ], [ 322, ...	What is the name of the company?	THE UPJOHN COMPANY
504	[ "EXHIBIT", "Ant", "THE", "UPJOHN", "COMPANY", "KALAMAZOO.", "MICHIGAN", "49001", "0199.", "U.5.4.", "TELEPHONE:", "(616)", "323", "4000", "J.", "R.", "MITCHELL,", "MD.,", "P.", "D.", "Vice", "Chairman", "of", "the", "doand", "PAR.", "September", "21,", "1993",...	[ [ 463, 23, 544, 39 ], [ 767, 82, 832, 108 ], [ 190, 126, 264, 152 ], [ 287, 127, 452, 153 ], [ 477, 124, 698, 153 ], [ 188, 156, 262, 168 ], [ 265, 158, 319, 169 ], [ 322, ...	What is the date mentioned?	September 21, 1993
504	[ "EXHIBIT", "Ant", "THE", "UPJOHN", "COMPANY", "KALAMAZOO.", "MICHIGAN", "49001", "0199.", "U.5.4.", "TELEPHONE:", "(616)", "323", "4000", "J.", "R.", "MITCHELL,", "MD.,", "P.", "D.", "Vice", "Chairman", "of", "the", "doand", "PAR.", "September", "21,", "1993",...	[ [ 463, 23, 544, 39 ], [ 767, 82, 832, 108 ], [ 190, 126, 264, 152 ], [ 287, 127, 452, 153 ], [ 477, 124, 698, 153 ], [ 188, 156, 262, 168 ], [ 265, 158, 319, 169 ], [ 322, ...	To whom is this letter addressed?	Tai Matsuzawa, Ph.D.
504	[ "EXHIBIT", "Ant", "THE", "UPJOHN", "COMPANY", "KALAMAZOO.", "MICHIGAN", "49001", "0199.", "U.5.4.", "TELEPHONE:", "(616)", "323", "4000", "J.", "R.", "MITCHELL,", "MD.,", "P.", "D.", "Vice", "Chairman", "of", "the", "doand", "PAR.", "September", "21,", "1993",...	[ [ 463, 23, 544, 39 ], [ 767, 82, 832, 108 ], [ 190, 126, 264, 152 ], [ 287, 127, 452, 153 ], [ 477, 124, 698, 153 ], [ 188, 156, 262, 168 ], [ 265, 158, 319, 169 ], [ 322, ...	As a consequence of the decision Upjohn must decline participation with which company?	Takeda
507	[ "aked", "TAKEDA", "PHARMACEUTICALS", "NORTH", "AMERICA", "INC.", "Case", "Number", "Two:", "A", "79-year-old", "female,", "enrolled", "in", "the", "study", "for", "200", "days,", "was", "hospitalized", "for", "a", "bladder", "biopsy", "for", "possible", "recurre...	[ [ 431, 60, 486, 75 ], [ 322, 87, 365, 100 ], [ 368, 86, 477, 99 ], [ 480, 86, 519, 99 ], [ 522, 87, 572, 99 ], [ 575, 87, 600, 99 ], [ 135, 118, 171, 132 ], [ 174, 117,...	A 79-year-old female was enrolled in the study for how many days?	200 days
507	[ "aked", "TAKEDA", "PHARMACEUTICALS", "NORTH", "AMERICA", "INC.", "Case", "Number", "Two:", "A", "79-year-old", "female,", "enrolled", "in", "the", "study", "for", "200", "days,", "was", "hospitalized", "for", "a", "bladder", "biopsy", "for", "possible", "recurre...	[ [ 431, 60, 486, 75 ], [ 322, 87, 365, 100 ], [ 368, 86, 477, 99 ], [ 480, 86, 519, 99 ], [ 522, 87, 572, 99 ], [ 575, 87, 600, 99 ], [ 135, 118, 171, 132 ], [ 174, 117,...	The patient had a history of bladder cancer since when?	1996
509	[ "Dr.", "Ruppel", "October", "25", "Page", "2", "of", "2", "We", "are", "sorry", "for", "having", "had", "a", "delay", "in", "responding", "to", "your", "request", "because", "of", "my", "absence", "on", "business", "abroad.", "Sincerely", "yours,", "TAKEDA...	[ [ 198, 124, 233, 136 ], [ 241, 124, 304, 137 ], [ 201, 136, 274, 150 ], [ 285, 135, 305, 148 ], [ 200, 150, 242, 163 ], [ 252, 150, 264, 162 ], [ 272, 149, 296, 162 ], [ 30...	Who is the general manager of International development Dept. of Takeda Chemical Industires, Ltd.?	K. Kitazawa, Ph. D.
507	[ "aked", "TAKEDA", "PHARMACEUTICALS", "NORTH", "AMERICA", "INC.", "Case", "Number", "Two:", "A", "79-year-old", "female,", "enrolled", "in", "the", "study", "for", "200", "days,", "was", "hospitalized", "for", "a", "bladder", "biopsy", "for", "possible", "recurre...	[ [ 431, 60, 486, 75 ], [ 322, 87, 365, 100 ], [ 368, 86, 477, 99 ], [ 480, 86, 519, 99 ], [ 522, 87, 572, 99 ], [ 575, 87, 600, 99 ], [ 135, 118, 171, 132 ], [ 174, 117,...	Who is the writer of the document?	Janet L. Haskins
507	[ "aked", "TAKEDA", "PHARMACEUTICALS", "NORTH", "AMERICA", "INC.", "Case", "Number", "Two:", "A", "79-year-old", "female,", "enrolled", "in", "the", "study", "for", "200", "days,", "was", "hospitalized", "for", "a", "bladder", "biopsy", "for", "possible", "recurre...	[ [ 431, 60, 486, 75 ], [ 322, 87, 365, 100 ], [ 368, 86, 477, 99 ], [ 480, 86, 519, 99 ], [ 522, 87, 572, 99 ], [ 575, 87, 600, 99 ], [ 135, 118, 171, 132 ], [ 174, 117,...	The woman had a positive history of what?	tobacco use
509	[ "Dr.", "Ruppel", "October", "25", "Page", "2", "of", "2", "We", "are", "sorry", "for", "having", "had", "a", "delay", "in", "responding", "to", "your", "request", "because", "of", "my", "absence", "on", "business", "abroad.", "Sincerely", "yours,", "TAKEDA...	[ [ 198, 124, 233, 136 ], [ 241, 124, 304, 137 ], [ 201, 136, 274, 150 ], [ 285, 135, 305, 148 ], [ 200, 150, 242, 163 ], [ 252, 150, 264, 162 ], [ 272, 149, 296, 162 ], [ 30...	what is the name of the industry ?	TAKEDA CHEMICAL INDUSTRIES, LTD.
509	[ "Dr.", "Ruppel", "October", "25", "Page", "2", "of", "2", "We", "are", "sorry", "for", "having", "had", "a", "delay", "in", "responding", "to", "your", "request", "because", "of", "my", "absence", "on", "business", "abroad.", "Sincerely", "yours,", "TAKEDA...	[ [ 198, 124, 233, 136 ], [ 241, 124, 304, 137 ], [ 201, 136, 274, 150 ], [ 285, 135, 305, 148 ], [ 200, 150, 242, 163 ], [ 252, 150, 264, 162 ], [ 272, 149, 296, 162 ], [ 30...	How many pages are there in total?	2
509	[ "Dr.", "Ruppel", "October", "25", "Page", "2", "of", "2", "We", "are", "sorry", "for", "having", "had", "a", "delay", "in", "responding", "to", "your", "request", "because", "of", "my", "absence", "on", "business", "abroad.", "Sincerely", "yours,", "TAKEDA...	[ [ 198, 124, 233, 136 ], [ 241, 124, 304, 137 ], [ 201, 136, 274, 150 ], [ 285, 135, 305, 148 ], [ 200, 150, 242, 163 ], [ 252, 150, 264, 162 ], [ 272, 149, 296, 162 ], [ 30...	what is the month and date mentioned in this letter, at the top ?	October 25
511	[ "Takeda", "Pharmaceuticals", "U.S.A.,", "Inc.", "Address", ":", "One", "Takeda", "Parkway,", "Deerfield,", "IL", "60015,", "U.S.A", "Tel", ":", "+1-224-554-5586", "E-mail:", "stacey.calahan@takeda.com", "(Copy)", "Kazuyuki", "Kisaka", "Senior", "Director", "IP", "Lice...	[ [ 147, 88, 196, 103 ], [ 200, 88, 318, 103 ], [ 321, 89, 377, 104 ], [ 380, 89, 411, 105 ], [ 145, 109, 204, 123 ], [ 208, 109, 216, 123 ], [ 219, 109, 251, 123 ], [ 254, ...	By whom is this document written?	Stacey Dixon Calahan
514	[ "FROM", "HERETAN", "DEMAS", "FAX05-6204-2943", "19994", "18218", "(*)", "21", "31/21", ":", "28/x56:480:", "941295", "F", "1", "Takeda", "Chemical", "Industries,", "Ltd.", "Takeda", "Product", "Planning", "&", "Management", "Dept.,", "International", "Division", "...	[ [ 114, 37, 145, 48 ], [ 151, 37, 207, 48 ], [ 213, 37, 262, 48 ], [ 269, 36, 386, 49 ], [ 478, 35, 519, 48 ], [ 525, 36, 562, 48 ], [ 565, 36, 583, 49 ], [ 586, 37, ...	What is the date mentioned?	January 21, 1999
514	[ "FROM", "HERETAN", "DEMAS", "FAX05-6204-2943", "19994", "18218", "(*)", "21", "31/21", ":", "28/x56:480:", "941295", "F", "1", "Takeda", "Chemical", "Industries,", "Ltd.", "Takeda", "Product", "Planning", "&", "Management", "Dept.,", "International", "Division", "...	[ [ 114, 37, 145, 48 ], [ 151, 37, 207, 48 ], [ 213, 37, 262, 48 ], [ 269, 36, 386, 49 ], [ 478, 35, 519, 48 ], [ 525, 36, 562, 48 ], [ 565, 36, 583, 49 ], [ 586, 37, ...	To whom is this document addressed?	Mr. Larry Ellingson
513	[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved;", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...	[ [ 172, 64, 268, 77 ], [ 271, 64, 290, 76 ], [ 292, 64, 348, 76 ], [ 352, 64, 382, 76 ], [ 385, 63, 435, 76 ], [ 440, 63, 509, 77 ], [ 627, 61, 654, 72 ], [ 658, 60, ...	to which department it belongs to ?	DEPARTMENT OF HEALTH AND HUMAN SERVICES
514	[ "FROM", "HERETAN", "DEMAS", "FAX05-6204-2943", "19994", "18218", "(*)", "21", "31/21", ":", "28/x56:480:", "941295", "F", "1", "Takeda", "Chemical", "Industries,", "Ltd.", "Takeda", "Product", "Planning", "&", "Management", "Dept.,", "International", "Division", "...	[ [ 114, 37, 145, 48 ], [ 151, 37, 207, 48 ], [ 213, 37, 262, 48 ], [ 269, 36, 386, 49 ], [ 478, 35, 519, 48 ], [ 525, 36, 562, 48 ], [ 565, 36, 583, 49 ], [ 586, 37, ...	By whom is this document written?	Kunio Iwatani
513	[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved;", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...	[ [ 172, 64, 268, 77 ], [ 271, 64, 290, 76 ], [ 292, 64, 348, 76 ], [ 352, 64, 382, 76 ], [ 385, 63, 435, 76 ], [ 440, 63, 509, 77 ], [ 627, 61, 654, 72 ], [ 658, 60, ...	what is the date of submission?	11/18/2002
513	[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved;", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...	[ [ 172, 64, 268, 77 ], [ 271, 64, 290, 76 ], [ 292, 64, 348, 76 ], [ 352, 64, 382, 76 ], [ 385, 63, 435, 76 ], [ 440, 63, 509, 77 ], [ 627, 61, 654, 72 ], [ 658, 60, ...	what is the telephone number (include area code)?	847-383-3739
513	[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved;", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...	[ [ 172, 64, 268, 77 ], [ 271, 64, 290, 76 ], [ 292, 64, 348, 76 ], [ 352, 64, 382, 76 ], [ 385, 63, 435, 76 ], [ 440, 63, 509, 77 ], [ 627, 61, 654, 72 ], [ 658, 60, ...	What is the serial number mentioned in the form?	5 0 1
513	[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved;", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...	[ [ 172, 64, 268, 77 ], [ 271, 64, 290, 76 ], [ 292, 64, 348, 76 ], [ 352, 64, 382, 76 ], [ 385, 63, 435, 76 ], [ 440, 63, 509, 77 ], [ 627, 61, 654, 72 ], [ 658, 60, ...	what is the expiration date ?	November 30, 2002
513	[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved;", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...	[ [ 172, 64, 268, 77 ], [ 271, 64, 290, 76 ], [ 292, 64, 348, 76 ], [ 352, 64, 382, 76 ], [ 385, 63, 435, 76 ], [ 440, 63, 509, 77 ], [ 627, 61, 654, 72 ], [ 658, 60, ...	what is the name of the sponsor ?	Takeda Pharmaceuticals North America, Inc.
515	[ "Takeda", "In", "light", "of", "age-related", "risks", "(especially", "bladder", "cancer,", "fractures", "and", "heart", "failure),", "the", "balance", "of", "benefits", "and", "risks", "should", "be", "considered", "carefully", "both", "before", "and", "during", ...	[ [ 144, 60, 230, 83 ], [ 107, 109, 122, 122 ], [ 125, 109, 158, 123 ], [ 162, 109, 178, 123 ], [ 181, 110, 260, 123 ], [ 264, 110, 298, 124 ], [ 301, 110, 380, 124 ], [ 382,...	what has to be investigated before starting pioglitazone therapy?	any macroscopic haematuria
515	[ "Takeda", "In", "light", "of", "age-related", "risks", "(especially", "bladder", "cancer,", "fractures", "and", "heart", "failure),", "the", "balance", "of", "benefits", "and", "risks", "should", "be", "considered", "carefully", "both", "before", "and", "during", ...	[ [ 144, 60, 230, 83 ], [ 107, 109, 122, 122 ], [ 125, 109, 158, 123 ], [ 162, 109, 178, 123 ], [ 181, 110, 260, 123 ], [ 264, 110, 298, 124 ], [ 301, 110, 380, 124 ], [ 382,...	what has been experienced commonly in patients taking actos in combination with insulin?	Heart failure
517	[ "compensable.", "Payment", "will", "be", "made", "within", "thirty", "(30)", "days", "of", "TURD's", "receipt", "from", "Institution", "of", "invoices", "meeting", "the", "foregoing", "requirements.", "Payment", "shall", "be", "made", "payable", "as", "follows:", ...	[ [ 175, 76, 278, 90 ], [ 281, 76, 345, 90 ], [ 348, 76, 377, 90 ], [ 380, 76, 397, 90 ], [ 400, 76, 441, 90 ], [ 444, 76, 490, 90 ], [ 493, 76, 534, 90 ], [ 537, 76, ...	Which foundation is mentioned in this document?	Cleveland Clinic Foundation
517	[ "compensable.", "Payment", "will", "be", "made", "within", "thirty", "(30)", "days", "of", "TURD's", "receipt", "from", "Institution", "of", "invoices", "meeting", "the", "foregoing", "requirements.", "Payment", "shall", "be", "made", "payable", "as", "follows:", ...	[ [ 175, 76, 278, 90 ], [ 281, 76, 345, 90 ], [ 348, 76, 377, 90 ], [ 380, 76, 397, 90 ], [ 400, 76, 441, 90 ], [ 444, 76, 490, 90 ], [ 493, 76, 534, 90 ], [ 537, 76, ...	Under which department , The Cleveland Clinic Foundation operates?	Department of Cardiovascular Medicine
514	[ "FROM", "HERETAN", "DEMAS", "FAX05-6204-2943", "19994", "18218", "(*)", "21", "31/21", ":", "28/x56:480:", "941295", "F", "1", "Takeda", "Chemical", "Industries,", "Ltd.", "Takeda", "Product", "Planning", "&", "Management", "Dept.,", "International", "Division", "...	[ [ 114, 37, 145, 48 ], [ 151, 37, 207, 48 ], [ 213, 37, 262, 48 ], [ 269, 36, 386, 49 ], [ 478, 35, 519, 48 ], [ 525, 36, 562, 48 ], [ 565, 36, 583, 49 ], [ 586, 37, ...	What is written in big bold letters at the bottom?	DALY 19
515	[ "Takeda", "In", "light", "of", "age-related", "risks", "(especially", "bladder", "cancer,", "fractures", "and", "heart", "failure),", "the", "balance", "of", "benefits", "and", "risks", "should", "be", "considered", "carefully", "both", "before", "and", "during", ...	[ [ 144, 60, 230, 83 ], [ 107, 109, 122, 122 ], [ 125, 109, 158, 123 ], [ 162, 109, 178, 123 ], [ 181, 110, 260, 123 ], [ 264, 110, 298, 124 ], [ 301, 110, 380, 124 ], [ 382,...	Which medicine is used to treat type 2 diabetes mellitus?	Actos/Competact
515	[ "Takeda", "In", "light", "of", "age-related", "risks", "(especially", "bladder", "cancer,", "fractures", "and", "heart", "failure),", "the", "balance", "of", "benefits", "and", "risks", "should", "be", "considered", "carefully", "both", "before", "and", "during", ...	[ [ 144, 60, 230, 83 ], [ 107, 109, 122, 122 ], [ 125, 109, 158, 123 ], [ 162, 109, 178, 123 ], [ 181, 110, 260, 123 ], [ 264, 110, 298, 124 ], [ 301, 110, 380, 124 ], [ 382,...	How many cases of bladder cancer from 12506 patients were reported?	19 cases
517	[ "compensable.", "Payment", "will", "be", "made", "within", "thirty", "(30)", "days", "of", "TURD's", "receipt", "from", "Institution", "of", "invoices", "meeting", "the", "foregoing", "requirements.", "Payment", "shall", "be", "made", "payable", "as", "follows:", ...	[ [ 175, 76, 278, 90 ], [ 281, 76, 345, 90 ], [ 348, 76, 377, 90 ], [ 380, 76, 397, 90 ], [ 400, 76, 441, 90 ], [ 444, 76, 490, 90 ], [ 493, 76, 534, 90 ], [ 537, 76, ...	What is the PO Box number?	931535
518	[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved:", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...	[ [ 210, 85, 294, 97 ], [ 298, 85, 314, 96 ], [ 317, 85, 369, 96 ], [ 373, 84, 398, 95 ], [ 401, 84, 448, 96 ], [ 452, 83, 510, 96 ], [ 621, 81, 646, 92 ], [ 650, 81, ...	what is the IND mumber (if previously assigned ) ?	33,729
518	[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved:", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...	[ [ 210, 85, 294, 97 ], [ 298, 85, 314, 96 ], [ 317, 85, 369, 96 ], [ 373, 84, 398, 95 ], [ 401, 84, 448, 96 ], [ 452, 83, 510, 96 ], [ 621, 81, 646, 92 ], [ 650, 81, ...	What is the serial number mentioned in the form?	4 9 7
518	[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved:", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...	[ [ 210, 85, 294, 97 ], [ 298, 85, 314, 96 ], [ 317, 85, 369, 96 ], [ 373, 84, 398, 95 ], [ 401, 84, 448, 96 ], [ 452, 83, 510, 96 ], [ 621, 81, 646, 92 ], [ 650, 81, ...	what is the date of submission ?	11/1/02
518	[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved:", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...	[ [ 210, 85, 294, 97 ], [ 298, 85, 314, 96 ], [ 317, 85, 369, 96 ], [ 373, 84, 398, 95 ], [ 401, 84, 448, 96 ], [ 452, 83, 510, 96 ], [ 621, 81, 646, 92 ], [ 650, 81, ...	what is the Name(s) of drug (include all available names: Trade , Generic, Chemical, Code)?	ACTOS (pioglitazone HCI)
517	[ "compensable.", "Payment", "will", "be", "made", "within", "thirty", "(30)", "days", "of", "TURD's", "receipt", "from", "Institution", "of", "invoices", "meeting", "the", "foregoing", "requirements.", "Payment", "shall", "be", "made", "payable", "as", "follows:", ...	[ [ 175, 76, 278, 90 ], [ 281, 76, 345, 90 ], [ 348, 76, 377, 90 ], [ 380, 76, 397, 90 ], [ 400, 76, 441, 90 ], [ 444, 76, 490, 90 ], [ 493, 76, 534, 90 ], [ 537, 76, ...	What is the Tax ID mentioned in this document?	34-0714585
518	[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved:", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...	[ [ 210, 85, 294, 97 ], [ 298, 85, 314, 96 ], [ 317, 85, 369, 96 ], [ 373, 84, 398, 95 ], [ 401, 84, 448, 96 ], [ 452, 83, 510, 96 ], [ 621, 81, 646, 92 ], [ 650, 81, ...	what is the form approved : OMB No	0910-0014
505	[ "Takeda", "19", "January", "2012", "Direct", "Healthcare", "Professional", "Communication", "on", "pioglitazone", "and", "a", "small", "increased", "risk", "of.", "Urinary", "Bladder", "Cancer.", "Dear", "Healthcare", "Professional,", "Summary", "Following", "the", ...	[ [ 145, 59, 229, 81 ], [ 682, 109, 702, 122 ], [ 715, 109, 780, 122 ], [ 782, 109, 820, 122 ], [ 107, 140, 155, 153 ], [ 158, 140, 243, 153 ], [ 245, 141, 341, 154 ], [ 344,...	What is the word written in bold on the top of the document?	Takeda
505	[ "Takeda", "19", "January", "2012", "Direct", "Healthcare", "Professional", "Communication", "on", "pioglitazone", "and", "a", "small", "increased", "risk", "of.", "Urinary", "Bladder", "Cancer.", "Dear", "Healthcare", "Professional,", "Summary", "Following", "the", ...	[ [ 145, 59, 229, 81 ], [ 682, 109, 702, 122 ], [ 715, 109, 780, 122 ], [ 782, 109, 820, 122 ], [ 107, 140, 155, 153 ], [ 158, 140, 243, 153 ], [ 245, 141, 341, 154 ], [ 344,...	What is the date mentioned?	19th January 2012
519	[ "DEPARTMENT", "OF", "HEALTH", "&", "HUMAN", "SERVICES", "Public", "Health", "Service", "Food", "and", "Drug", "Administration", "Rockville,", "MD", "20857", "IND", "33,729", "RECEIVED", "REGULATORY", "AFFAIRS", "DEPARTMENT", "Takeda", "Pharmaceuticals", "North", "Am...	[ [ 170, 94, 272, 105 ], [ 274, 94, 295, 105 ], [ 297, 94, 357, 105 ], [ 363, 93, 373, 105 ], [ 377, 93, 430, 105 ], [ 434, 92, 504, 105 ], [ 662, 92, 698, 102 ], [ 700, ...	what is the name of pharmaceuticals ?	Takeda Pharmaceuticals North America, Inc.
519	[ "DEPARTMENT", "OF", "HEALTH", "&", "HUMAN", "SERVICES", "Public", "Health", "Service", "Food", "and", "Drug", "Administration", "Rockville,", "MD", "20857", "IND", "33,729", "RECEIVED", "REGULATORY", "AFFAIRS", "DEPARTMENT", "Takeda", "Pharmaceuticals", "North", "Am...	[ [ 170, 94, 272, 105 ], [ 274, 94, 295, 105 ], [ 297, 94, 357, 105 ], [ 363, 93, 373, 105 ], [ 377, 93, 430, 105 ], [ 434, 92, 504, 105 ], [ 662, 92, 698, 102 ], [ 700, ...	to whom this letter is written ?	Janet L. Haskins
519	[ "DEPARTMENT", "OF", "HEALTH", "&", "HUMAN", "SERVICES", "Public", "Health", "Service", "Food", "and", "Drug", "Administration", "Rockville,", "MD", "20857", "IND", "33,729", "RECEIVED", "REGULATORY", "AFFAIRS", "DEPARTMENT", "Takeda", "Pharmaceuticals", "North", "Am...	[ [ 170, 94, 272, 105 ], [ 274, 94, 295, 105 ], [ 297, 94, 357, 105 ], [ 363, 93, 373, 105 ], [ 377, 93, 430, 105 ], [ 434, 92, 504, 105 ], [ 662, 92, 698, 102 ], [ 700, ...	When did Regulatory affairs department receive this letter?	JUN 16 2003
505	[ "Takeda", "19", "January", "2012", "Direct", "Healthcare", "Professional", "Communication", "on", "pioglitazone", "and", "a", "small", "increased", "risk", "of.", "Urinary", "Bladder", "Cancer.", "Dear", "Healthcare", "Professional,", "Summary", "Following", "the", ...	[ [ 145, 59, 229, 81 ], [ 682, 109, 702, 122 ], [ 715, 109, 780, 122 ], [ 782, 109, 820, 122 ], [ 107, 140, 155, 153 ], [ 158, 140, 243, 153 ], [ 245, 141, 341, 154 ], [ 344,...	To whom was this letter written?	Healthcare Professional
510	[ "3.", "Reports", "to", "any", "third", "party,", "including,", "but", "not", "limited", "to,", "RedBook,", "First", "Data", "Bank,", "Blue", "Book,", "Medi-Span,", "or", "other", "price", "reporting", "service,", "regarding", "prices", "for", "TPNA", "products;"...	[ [ 178, 134, 196, 146 ], [ 199, 134, 255, 146 ], [ 258, 134, 274, 146 ], [ 277, 135, 302, 146 ], [ 305, 135, 338, 147 ], [ 340, 135, 380, 147 ], [ 383, 135, 451, 147 ], [ 45...	What is the fifth point?	WAC and AWP generally;
510	[ "3.", "Reports", "to", "any", "third", "party,", "including,", "but", "not", "limited", "to,", "RedBook,", "First", "Data", "Bank,", "Blue", "Book,", "Medi-Span,", "or", "other", "price", "reporting", "service,", "regarding", "prices", "for", "TPNA", "products;"...	[ [ 178, 134, 196, 146 ], [ 199, 134, 255, 146 ], [ 258, 134, 274, 146 ], [ 277, 135, 302, 146 ], [ 305, 135, 338, 147 ], [ 340, 135, 380, 147 ], [ 383, 135, 451, 147 ], [ 45...	Education grants regarding which products?	TPNA
510	[ "3.", "Reports", "to", "any", "third", "party,", "including,", "but", "not", "limited", "to,", "RedBook,", "First", "Data", "Bank,", "Blue", "Book,", "Medi-Span,", "or", "other", "price", "reporting", "service,", "regarding", "prices", "for", "TPNA", "products;"...	[ [ 178, 134, 196, 146 ], [ 199, 134, 255, 146 ], [ 258, 134, 274, 146 ], [ 277, 135, 302, 146 ], [ 305, 135, 338, 147 ], [ 340, 135, 380, 147 ], [ 383, 135, 451, 147 ], [ 45...	What is the date this document was last printed?	11/30/2012
519	[ "DEPARTMENT", "OF", "HEALTH", "&", "HUMAN", "SERVICES", "Public", "Health", "Service", "Food", "and", "Drug", "Administration", "Rockville,", "MD", "20857", "IND", "33,729", "RECEIVED", "REGULATORY", "AFFAIRS", "DEPARTMENT", "Takeda", "Pharmaceuticals", "North", "Am...	[ [ 170, 94, 272, 105 ], [ 274, 94, 295, 105 ], [ 297, 94, 357, 105 ], [ 363, 93, 373, 105 ], [ 377, 93, 430, 105 ], [ 434, 92, 504, 105 ], [ 662, 92, 698, 102 ], [ 700, ...	To whom a copy of cover letter has to be sent ?	Ms. Jens Weber
510	[ "3.", "Reports", "to", "any", "third", "party,", "including,", "but", "not", "limited", "to,", "RedBook,", "First", "Data", "Bank,", "Blue", "Book,", "Medi-Span,", "or", "other", "price", "reporting", "service,", "regarding", "prices", "for", "TPNA", "products;"...	[ [ 178, 134, 196, 146 ], [ 199, 134, 255, 146 ], [ 258, 134, 274, 146 ], [ 277, 135, 302, 146 ], [ 305, 135, 338, 147 ], [ 340, 135, 380, 147 ], [ 383, 135, 451, 147 ], [ 45...	Which reimbursement for TPNA pharmaceutical products is generally given?	Medicare and Medicaid
512	[ "prior", "to", "such", "event", "or", "in", "connection", "therewith.", "Sections", "6.", "7,", "8,", "9.", "12.", "13,", "14.", "15", "and", "16", "of", "this", "Agreement", "shall", "survive", "the", "expiration", "of", "earlier", "termination", "of", "t...	[ [ 172, 77, 208, 89 ], [ 211, 77, 225, 90 ], [ 230, 77, 263, 90 ], [ 266, 77, 307, 90 ], [ 310, 76, 327, 90 ], [ 330, 76, 344, 90 ], [ 347, 76, 427, 90 ], [ 430, 76, ...	What is the designation of Alfonso T. Perez, M.D.?	Vice President, Clinical Research
512	[ "prior", "to", "such", "event", "or", "in", "connection", "therewith.", "Sections", "6.", "7,", "8,", "9.", "12.", "13,", "14.", "15", "and", "16", "of", "this", "Agreement", "shall", "survive", "the", "expiration", "of", "earlier", "termination", "of", "t...	[ [ 172, 77, 208, 89 ], [ 211, 77, 225, 90 ], [ 230, 77, 263, 90 ], [ 266, 77, 307, 90 ], [ 310, 76, 327, 90 ], [ 330, 76, 344, 90 ], [ 347, 76, 427, 90 ], [ 430, 76, ...	By whom was this agreement Agreed and Accepted?	Richard A. Rudick, M.D.
512	[ "prior", "to", "such", "event", "or", "in", "connection", "therewith.", "Sections", "6.", "7,", "8,", "9.", "12.", "13,", "14.", "15", "and", "16", "of", "this", "Agreement", "shall", "survive", "the", "expiration", "of", "earlier", "termination", "of", "t...	[ [ 172, 77, 208, 89 ], [ 211, 77, 225, 90 ], [ 230, 77, 263, 90 ], [ 266, 77, 307, 90 ], [ 310, 76, 327, 90 ], [ 330, 76, 344, 90 ], [ 347, 76, 427, 90 ], [ 430, 76, ...	What is the full form of FAR?	Federal Acquisitions Regulation
520	[ "IND", "33,729", "Page", "2", "Correspondence", "to", "this", "IND", "can", "be", "sent", "to", "the", "following", "address:", "U.S.", "Postal", "Service/", "Courier/Overnight", "Mail:", "Food", "and", "Drug", "Administration", "Center", "for", "Drug", "Evaluat...	[ [ 143, 88, 172, 101 ], [ 178, 88, 226, 102 ], [ 144, 101, 177, 114 ], [ 180, 102, 188, 114 ], [ 145, 135, 253, 150 ], [ 256, 137, 272, 150 ], [ 275, 137, 301, 150 ], [ 304,...	What is the number written above TAK-INDNDA-01577086?	425
520	[ "IND", "33,729", "Page", "2", "Correspondence", "to", "this", "IND", "can", "be", "sent", "to", "the", "following", "address:", "U.S.", "Postal", "Service/", "Courier/Overnight", "Mail:", "Food", "and", "Drug", "Administration", "Center", "for", "Drug", "Evaluat...	[ [ 143, 88, 172, 101 ], [ 178, 88, 226, 102 ], [ 144, 101, 177, 114 ], [ 180, 102, 188, 114 ], [ 145, 135, 253, 150 ], [ 256, 137, 272, 150 ], [ 275, 137, 301, 150 ], [ 304,...	What is the contact number of Ms. Jena Weber, Regulatory Project Manager?	301-827-6422
520	[ "IND", "33,729", "Page", "2", "Correspondence", "to", "this", "IND", "can", "be", "sent", "to", "the", "following", "address:", "U.S.", "Postal", "Service/", "Courier/Overnight", "Mail:", "Food", "and", "Drug", "Administration", "Center", "for", "Drug", "Evaluat...	[ [ 143, 88, 172, 101 ], [ 178, 88, 226, 102 ], [ 144, 101, 177, 114 ], [ 180, 102, 188, 114 ], [ 145, 135, 253, 150 ], [ 256, 137, 272, 150 ], [ 275, 137, 301, 150 ], [ 304,...	What is the full form of ODE?	Office of Drug Evaluation
520	[ "IND", "33,729", "Page", "2", "Correspondence", "to", "this", "IND", "can", "be", "sent", "to", "the", "following", "address:", "U.S.", "Postal", "Service/", "Courier/Overnight", "Mail:", "Food", "and", "Drug", "Administration", "Center", "for", "Drug", "Evaluat...	[ [ 143, 88, 172, 101 ], [ 178, 88, 226, 102 ], [ 144, 101, 177, 114 ], [ 180, 102, 188, 114 ], [ 145, 135, 253, 150 ], [ 256, 137, 272, 150 ], [ 275, 137, 301, 150 ], [ 304,...	What is written above Page 2 on the top?	IND 33, 729
521	[ "FROM", "THE", "DESK", "OF:", "Timothy", "J.", "Gumbleton", "UNIT:", "7200", "BLOG", ":", "24-1", "EXT:", "5-7054", "PJ", "Daniels", "LSolanoff", "DATE:", "9/23/42", "PL", "Ruppel", "L", "Twelch", "Attached", "is", "a", "cozy", "of", "the", "letter", "from...	[ [ 268, 109, 333, 129 ], [ 350, 108, 394, 129 ], [ 269, 130, 328, 148 ], [ 339, 130, 378, 148 ], [ 440, 127, 547, 152 ], [ 557, 130, 595, 153 ], [ 600, 130, 734, 154 ], [ 26...	what is the unit mentioned in the letter ?	7200
521	[ "FROM", "THE", "DESK", "OF:", "Timothy", "J.", "Gumbleton", "UNIT:", "7200", "BLOG", ":", "24-1", "EXT:", "5-7054", "PJ", "Daniels", "LSolanoff", "DATE:", "9/23/42", "PL", "Ruppel", "L", "Twelch", "Attached", "is", "a", "cozy", "of", "the", "letter", "from...	[ [ 268, 109, 333, 129 ], [ 350, 108, 394, 129 ], [ 269, 130, 328, 148 ], [ 339, 130, 378, 148 ], [ 440, 127, 547, 152 ], [ 557, 130, 595, 153 ], [ 600, 130, 734, 154 ], [ 26...	what is the date mentioned	9/23/93
512	[ "prior", "to", "such", "event", "or", "in", "connection", "therewith.", "Sections", "6.", "7,", "8,", "9.", "12.", "13,", "14.", "15", "and", "16", "of", "this", "Agreement", "shall", "survive", "the", "expiration", "of", "earlier", "termination", "of", "t...	[ [ 172, 77, 208, 89 ], [ 211, 77, 225, 90 ], [ 230, 77, 263, 90 ], [ 266, 77, 307, 90 ], [ 310, 76, 327, 90 ], [ 330, 76, 344, 90 ], [ 347, 76, 427, 90 ], [ 430, 76, ...	What is the date of the signature of the chairman of the Division of clinical research?	5/8/07
521	[ "FROM", "THE", "DESK", "OF:", "Timothy", "J.", "Gumbleton", "UNIT:", "7200", "BLOG", ":", "24-1", "EXT:", "5-7054", "PJ", "Daniels", "LSolanoff", "DATE:", "9/23/42", "PL", "Ruppel", "L", "Twelch", "Attached", "is", "a", "cozy", "of", "the", "letter", "from...	[ [ 268, 109, 333, 129 ], [ 350, 108, 394, 129 ], [ 269, 130, 328, 148 ], [ 339, 130, 378, 148 ], [ 440, 127, 547, 152 ], [ 557, 130, 595, 153 ], [ 600, 130, 734, 154 ], [ 26...	Name of the first person in the To list?	PJ Daniels
503	[ "DEPARTMENT", "OF", "HEALTH", "&", "HUMAN", "SERVICES", "Public", "Health", "Service", "Food", "and", "Drug", "Administration", "Rockville,", "MD", "20857", "NDA", "21-073/S-026", "DISCIPLINE", "REVIEW", "LETTER", "Takeda", "Global", "Research", "&", "Development", ...	[ [ 188, 91, 314, 106 ], [ 316, 91, 341, 107 ], [ 344, 91, 417, 107 ], [ 423, 91, 437, 107 ], [ 440, 91, 506, 107 ], [ 512, 91, 602, 107 ], [ 678, 85, 716, 97 ], [ 718, 8...	When did Regulatory affairs department receive this letter?	Feb 19 2007
521	[ "FROM", "THE", "DESK", "OF:", "Timothy", "J.", "Gumbleton", "UNIT:", "7200", "BLOG", ":", "24-1", "EXT:", "5-7054", "PJ", "Daniels", "LSolanoff", "DATE:", "9/23/42", "PL", "Ruppel", "L", "Twelch", "Attached", "is", "a", "cozy", "of", "the", "letter", "from...	[ [ 268, 109, 333, 129 ], [ 350, 108, 394, 129 ], [ 269, 130, 328, 148 ], [ 339, 130, 378, 148 ], [ 440, 127, 547, 152 ], [ 557, 130, 595, 153 ], [ 600, 130, 734, 154 ], [ 26...	from whose desk this letter is written ?	Timothy J. Gumbleton
521	[ "FROM", "THE", "DESK", "OF:", "Timothy", "J.", "Gumbleton", "UNIT:", "7200", "BLOG", ":", "24-1", "EXT:", "5-7054", "PJ", "Daniels", "LSolanoff", "DATE:", "9/23/42", "PL", "Ruppel", "L", "Twelch", "Attached", "is", "a", "cozy", "of", "the", "letter", "from...	[ [ 268, 109, 333, 129 ], [ 350, 108, 394, 129 ], [ 269, 130, 328, 148 ], [ 339, 130, 378, 148 ], [ 440, 127, 547, 152 ], [ 557, 130, 595, 153 ], [ 600, 130, 734, 154 ], [ 26...	Whose letter's copy is attached?	DR. Mitchell
522	[ "..", "Encl.", "2", "Draft", "2", "/", "1", "1", "TAKEDA", "INTERNATIONAL", "COMMUNICATION", "Date", "February", "6,", "1996", "To", "Dr.", "K.", "Kitazawa", "General", "Manager", "International", "Development", "From", "T.", "Suzuki", "Senior", "Research", "H...	[ [ 36, 29, 47, 43 ], [ 50, 27, 111, 43 ], [ 120, 26, 130, 41 ], [ 416, 11, 600, 66 ], [ 769, 24, 791, 51 ], [ 790, 27, 806, 54 ], [ 805, 30, 822, 57 ], [ 822, 33, 83...	what is the date mentioned ?	February 6, 1996
522	[ "..", "Encl.", "2", "Draft", "2", "/", "1", "1", "TAKEDA", "INTERNATIONAL", "COMMUNICATION", "Date", "February", "6,", "1996", "To", "Dr.", "K.", "Kitazawa", "General", "Manager", "International", "Development", "From", "T.", "Suzuki", "Senior", "Research", "H...	[ [ 36, 29, 47, 43 ], [ 50, 27, 111, 43 ], [ 120, 26, 130, 41 ], [ 416, 11, 600, 66 ], [ 769, 24, 791, 51 ], [ 790, 27, 806, 54 ], [ 805, 30, 822, 57 ], [ 822, 33, 83...	to whom this letter is written ?	Dr. K. KItazawa
522	[ "..", "Encl.", "2", "Draft", "2", "/", "1", "1", "TAKEDA", "INTERNATIONAL", "COMMUNICATION", "Date", "February", "6,", "1996", "To", "Dr.", "K.", "Kitazawa", "General", "Manager", "International", "Development", "From", "T.", "Suzuki", "Senior", "Research", "H...	[ [ 36, 29, 47, 43 ], [ 50, 27, 111, 43 ], [ 120, 26, 130, 41 ], [ 416, 11, 600, 66 ], [ 769, 24, 791, 51 ], [ 790, 27, 806, 54 ], [ 805, 30, 822, 57 ], [ 822, 33, 83...	this letter is written by whom ?	T. Suzuki
522	[ "..", "Encl.", "2", "Draft", "2", "/", "1", "1", "TAKEDA", "INTERNATIONAL", "COMMUNICATION", "Date", "February", "6,", "1996", "To", "Dr.", "K.", "Kitazawa", "General", "Manager", "International", "Development", "From", "T.", "Suzuki", "Senior", "Research", "H...	[ [ 36, 29, 47, 43 ], [ 50, 27, 111, 43 ], [ 120, 26, 130, 41 ], [ 416, 11, 600, 66 ], [ 769, 24, 791, 51 ], [ 790, 27, 806, 54 ], [ 805, 30, 822, 57 ], [ 822, 33, 83...	Which laboratory is T. Suzuki associated with ?	Drug Safety Research Laboratories
524	[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:", "49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "001/006", "116", "TAKEDA", "CHEMICAL", "INDUSTRIES,", "LTD.", "Pharmaceutical", "Development", "Division", "1-1,", "Doshomachi...	[ [ 59, 8, 152, 18 ], [ 181, 8, 226, 18 ], [ 272, 8, 291, 18 ], [ 299, 8, 338, 17 ], [ 346, 8, 384, 18 ], [ 41, 18, 79, 29 ], [ 87, 18, 134, 29 ], [ 143, 18, 169, ...	what is the date mentioned in the letter	August 8, 2002
524	[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:", "49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "001/006", "116", "TAKEDA", "CHEMICAL", "INDUSTRIES,", "LTD.", "Pharmaceutical", "Development", "Division", "1-1,", "Doshomachi...	[ [ 59, 8, 152, 18 ], [ 181, 8, 226, 18 ], [ 272, 8, 291, 18 ], [ 299, 8, 338, 17 ], [ 346, 8, 384, 18 ], [ 41, 18, 79, 29 ], [ 87, 18, 134, 29 ], [ 143, 18, 169, ...	What is the name of the industry given here?	Takeda chemical industries, LTD .
524	[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:", "49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "001/006", "116", "TAKEDA", "CHEMICAL", "INDUSTRIES,", "LTD.", "Pharmaceutical", "Development", "Division", "1-1,", "Doshomachi...	[ [ 59, 8, 152, 18 ], [ 181, 8, 226, 18 ], [ 272, 8, 291, 18 ], [ 299, 8, 338, 17 ], [ 346, 8, 384, 18 ], [ 41, 18, 79, 29 ], [ 87, 18, 134, 29 ], [ 143, 18, 169, ...	to whom this letter is written ?	Dr. Claire Thom
524	[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:", "49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "001/006", "116", "TAKEDA", "CHEMICAL", "INDUSTRIES,", "LTD.", "Pharmaceutical", "Development", "Division", "1-1,", "Doshomachi...	[ [ 59, 8, 152, 18 ], [ 181, 8, 226, 18 ], [ 272, 8, 291, 18 ], [ 299, 8, 338, 17 ], [ 346, 8, 384, 18 ], [ 41, 18, 79, 29 ], [ 87, 18, 134, 29 ], [ 143, 18, 169, ...	what is the name mentioned in CC	Mr. S. Hamanaka
524	[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:", "49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "001/006", "116", "TAKEDA", "CHEMICAL", "INDUSTRIES,", "LTD.", "Pharmaceutical", "Development", "Division", "1-1,", "Doshomachi...	[ [ 59, 8, 152, 18 ], [ 181, 8, 226, 18 ], [ 272, 8, 291, 18 ], [ 299, 8, 338, 17 ], [ 346, 8, 384, 18 ], [ 41, 18, 79, 29 ], [ 87, 18, 134, 29 ], [ 143, 18, 169, ...	Who sent this letter?	Katsuhisa Saito
524	[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:", "49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "001/006", "116", "TAKEDA", "CHEMICAL", "INDUSTRIES,", "LTD.", "Pharmaceutical", "Development", "Division", "1-1,", "Doshomachi...	[ [ 59, 8, 152, 18 ], [ 181, 8, 226, 18 ], [ 272, 8, 291, 18 ], [ 299, 8, 338, 17 ], [ 346, 8, 384, 18 ], [ 41, 18, 79, 29 ], [ 87, 18, 134, 29 ], [ 143, 18, 169, ...	what is Ref: code mentioned ?	TPNA-TS-020808
526	[ "08/07/2002", "18:47", "06", "6204", "2244", ".", "2002'", "08/08", "21:50", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "2", "006/006", "6", "/", "6", "Discussion", "points", "to", "address", "the", "three", "key", "issues", "raised", "b...	[ [ 58, 11, 152, 21 ], [ 181, 10, 228, 21 ], [ 272, 10, 291, 21 ], [ 299, 10, 339, 21 ], [ 346, 11, 384, 21 ], [ 31, 21, 39, 31 ], [ 41, 21, 84, 31 ], [ 87, 21, 133, ...	What is the venue mentioned in the document?	TPNA, Chicago
526	[ "08/07/2002", "18:47", "06", "6204", "2244", ".", "2002'", "08/08", "21:50", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "2", "006/006", "6", "/", "6", "Discussion", "points", "to", "address", "the", "three", "key", "issues", "raised", "b...	[ [ 58, 11, 152, 21 ], [ 181, 10, 228, 21 ], [ 272, 10, 291, 21 ], [ 299, 10, 339, 21 ], [ 346, 11, 384, 21 ], [ 31, 21, 39, 31 ], [ 41, 21, 84, 31 ], [ 87, 21, 133, ...	What is the date mentioned in the document?	Monday, 12 and Tuesday, 13 August 2002
526	[ "08/07/2002", "18:47", "06", "6204", "2244", ".", "2002'", "08/08", "21:50", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "2", "006/006", "6", "/", "6", "Discussion", "points", "to", "address", "the", "three", "key", "issues", "raised", "b...	[ [ 58, 11, 152, 21 ], [ 181, 10, 228, 21 ], [ 272, 10, 291, 21 ], [ 299, 10, 339, 21 ], [ 346, 11, 384, 21 ], [ 31, 21, 39, 31 ], [ 41, 21, 84, 31 ], [ 87, 21, 133, ...	what is the fax number mentioned in the letter at the top?	06 6204 2244
527	[ "From:", "PLK", "RCC1", "Date", "and", "time", "10/27/93", "09", ":", "36:07", "To:", "PJDANIEL-", "-", "PW17", "PO", "PETER", "J.", "DANIELS", "CC:", "RJWELTER-", "-", "PW17", "PO", "RICHARD", "J.", "WELTER", "LTWELCH", "--RCC1", "LAWRENCE", "T", "WELCH",...	[ [ 54, 44, 102, 55 ], [ 111, 44, 138, 54 ], [ 202, 44, 239, 54 ], [ 464, 44, 503, 55 ], [ 512, 44, 541, 55 ], [ 551, 43, 587, 55 ], [ 625, 42, 701, 54 ], [ 710, 42, ...	what is the date and time mentioned ?	10/27/93 09:36:07
527	[ "From:", "PLK", "RCC1", "Date", "and", "time", "10/27/93", "09", ":", "36:07", "To:", "PJDANIEL-", "-", "PW17", "PO", "PETER", "J.", "DANIELS", "CC:", "RJWELTER-", "-", "PW17", "PO", "RICHARD", "J.", "WELTER", "LTWELCH", "--RCC1", "LAWRENCE", "T", "WELCH",...	[ [ 54, 44, 102, 55 ], [ 111, 44, 138, 54 ], [ 202, 44, 239, 54 ], [ 464, 44, 503, 55 ], [ 512, 44, 541, 55 ], [ 551, 43, 587, 55 ], [ 625, 42, 701, 54 ], [ 710, 42, ...	what is mentioned in the subject ?	Pioglitazone statement
527	[ "From:", "PLK", "RCC1", "Date", "and", "time", "10/27/93", "09", ":", "36:07", "To:", "PJDANIEL-", "-", "PW17", "PO", "PETER", "J.", "DANIELS", "CC:", "RJWELTER-", "-", "PW17", "PO", "RICHARD", "J.", "WELTER", "LTWELCH", "--RCC1", "LAWRENCE", "T", "WELCH",...	[ [ 54, 44, 102, 55 ], [ 111, 44, 138, 54 ], [ 202, 44, 239, 54 ], [ 464, 44, 503, 55 ], [ 512, 44, 541, 55 ], [ 551, 43, 587, 55 ], [ 625, 42, 701, 54 ], [ 710, 42, ...	To whom this email was send?	PETER J. DANIELS
527	[ "From:", "PLK", "RCC1", "Date", "and", "time", "10/27/93", "09", ":", "36:07", "To:", "PJDANIEL-", "-", "PW17", "PO", "PETER", "J.", "DANIELS", "CC:", "RJWELTER-", "-", "PW17", "PO", "RICHARD", "J.", "WELTER", "LTWELCH", "--RCC1", "LAWRENCE", "T", "WELCH",...	[ [ 54, 44, 102, 55 ], [ 111, 44, 138, 54 ], [ 202, 44, 239, 54 ], [ 464, 44, 503, 55 ], [ 512, 44, 541, 55 ], [ 551, 43, 587, 55 ], [ 625, 42, 701, 54 ], [ 710, 42, ...	what is the date mentioned in the forwarding note ?	10/26/93
527	[ "From:", "PLK", "RCC1", "Date", "and", "time", "10/27/93", "09", ":", "36:07", "To:", "PJDANIEL-", "-", "PW17", "PO", "PETER", "J.", "DANIELS", "CC:", "RJWELTER-", "-", "PW17", "PO", "RICHARD", "J.", "WELTER", "LTWELCH", "--RCC1", "LAWRENCE", "T", "WELCH",...	[ [ 54, 44, 102, 55 ], [ 111, 44, 138, 54 ], [ 202, 44, 239, 54 ], [ 464, 44, 503, 55 ], [ 512, 44, 541, 55 ], [ 551, 43, 587, 55 ], [ 625, 42, 701, 54 ], [ 710, 42, ...	what is the time mentioned in the forwarding note ?	15:44
527	[ "From:", "PLK", "RCC1", "Date", "and", "time", "10/27/93", "09", ":", "36:07", "To:", "PJDANIEL-", "-", "PW17", "PO", "PETER", "J.", "DANIELS", "CC:", "RJWELTER-", "-", "PW17", "PO", "RICHARD", "J.", "WELTER", "LTWELCH", "--RCC1", "LAWRENCE", "T", "WELCH",...	[ [ 54, 44, 102, 55 ], [ 111, 44, 138, 54 ], [ 202, 44, 239, 54 ], [ 464, 44, 503, 55 ], [ 512, 44, 541, 55 ], [ 551, 43, 587, 55 ], [ 625, 42, 701, 54 ], [ 710, 42, ...	To whom this email was forwaded?	RUPPEL, PATRICIA
530	[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "41", "003/006", "contact,", "what", "can", "we", "do?", "(7)", "As", "we", "point", "out", "in", "our", "action", "plan", ...	[ [ 60, 12, 153, 21 ], [ 182, 11, 227, 21 ], [ 272, 12, 290, 21 ], [ 300, 11, 338, 21 ], [ 347, 11, 383, 21 ], [ 42, 21, 79, 32 ], [ 88, 21, 135, 32 ], [ 144, 22, 191...	what is the fax mentioned ?	06 6204 2244
530	[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "41", "003/006", "contact,", "what", "can", "we", "do?", "(7)", "As", "we", "point", "out", "in", "our", "action", "plan", ...	[ [ 60, 12, 153, 21 ], [ 182, 11, 227, 21 ], [ 272, 12, 290, 21 ], [ 300, 11, 338, 21 ], [ 347, 11, 383, 21 ], [ 42, 21, 79, 32 ], [ 88, 21, 135, 32 ], [ 144, 22, 191...	what is year date and time mentioned?	2002 08/08 21:49
530	[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "41", "003/006", "contact,", "what", "can", "we", "do?", "(7)", "As", "we", "point", "out", "in", "our", "action", "plan", ...	[ [ 60, 12, 153, 21 ], [ 182, 11, 227, 21 ], [ 272, 12, 290, 21 ], [ 300, 11, 338, 21 ], [ 347, 11, 383, 21 ], [ 42, 21, 79, 32 ], [ 88, 21, 135, 32 ], [ 144, 22, 191...	what is the name of the division ?	TAKEDA DEVELOP DIVISION
530	[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "41", "003/006", "contact,", "what", "can", "we", "do?", "(7)", "As", "we", "point", "out", "in", "our", "action", "plan", ...	[ [ 60, 12, 153, 21 ], [ 182, 11, 227, 21 ], [ 272, 12, 290, 21 ], [ 300, 11, 338, 21 ], [ 347, 11, 383, 21 ], [ 42, 21, 79, 32 ], [ 88, 21, 135, 32 ], [ 144, 22, 191...	to whom they can ask directly to disclose the details of "promotion study"?	FDA
531	[ "8", "January", "2003", "To:", "MPDRAP", "I", "Leader", "cc:", "CEOs", "and", "General", "Managers", "of", "Pharmaceutical", "Units", "My", "Concerns", "about", "sNDA", "for", "Actos", "45mg", "in", "the", "USA", "(Reconfirmation)", "Pharmaceutical", "Internatio...	[ [ 653, 128, 662, 139 ], [ 665, 128, 715, 140 ], [ 717, 128, 748, 140 ], [ 200, 146, 222, 158 ], [ 224, 146, 288, 159 ], [ 291, 147, 298, 159 ], [ 300, 146, 345, 159 ], [ 20...	what is the date mentioned in the letter	8 January 2003
531	[ "8", "January", "2003", "To:", "MPDRAP", "I", "Leader", "cc:", "CEOs", "and", "General", "Managers", "of", "Pharmaceutical", "Units", "My", "Concerns", "about", "sNDA", "for", "Actos", "45mg", "in", "the", "USA", "(Reconfirmation)", "Pharmaceutical", "Internatio...	[ [ 653, 128, 662, 139 ], [ 665, 128, 715, 140 ], [ 717, 128, 748, 140 ], [ 200, 146, 222, 158 ], [ 224, 146, 288, 159 ], [ 291, 147, 298, 159 ], [ 300, 146, 345, 159 ], [ 20...	To whom this letter is addressed?	MPDRAP I Leader
531	[ "8", "January", "2003", "To:", "MPDRAP", "I", "Leader", "cc:", "CEOs", "and", "General", "Managers", "of", "Pharmaceutical", "Units", "My", "Concerns", "about", "sNDA", "for", "Actos", "45mg", "in", "the", "USA", "(Reconfirmation)", "Pharmaceutical", "Internatio...	[ [ 653, 128, 662, 139 ], [ 665, 128, 715, 140 ], [ 717, 128, 748, 140 ], [ 200, 146, 222, 158 ], [ 224, 146, 288, 159 ], [ 291, 147, 298, 159 ], [ 300, 146, 345, 159 ], [ 20...	what is mentioned in the CC?	CEOs and General Managers of Pharmaceutical Units
531	[ "8", "January", "2003", "To:", "MPDRAP", "I", "Leader", "cc:", "CEOs", "and", "General", "Managers", "of", "Pharmaceutical", "Units", "My", "Concerns", "about", "sNDA", "for", "Actos", "45mg", "in", "the", "USA", "(Reconfirmation)", "Pharmaceutical", "Internatio...	[ [ 653, 128, 662, 139 ], [ 665, 128, 715, 140 ], [ 717, 128, 748, 140 ], [ 200, 146, 222, 158 ], [ 224, 146, 288, 159 ], [ 291, 147, 298, 159 ], [ 300, 146, 345, 159 ], [ 20...	combination therapy in the us market accounts for how much % of total actos sales .	64
535	[ "Task", "Notes", "Lead", "Responsibility", "Due", "Date", "4.", "PEDIATRIC", "STUDIES", "(CONTINUED)", "Evaluate", "data", "from", "Actos", "507", ">", "Evaluate", "data", "to", "support", "Amy", "Hagaman", "August", "5", "ustification", "to", "proceed", "with",...	[ [ 174, 101, 207, 115 ], [ 385, 101, 437, 115 ], [ 534, 101, 576, 116 ], [ 580, 101, 705, 117 ], [ 768, 102, 805, 116 ], [ 808, 103, 850, 116 ], [ 90, 122, 104, 135 ], [ 107...	What is the due date to evaluate data from actos 507?	August 5
535	[ "Task", "Notes", "Lead", "Responsibility", "Due", "Date", "4.", "PEDIATRIC", "STUDIES", "(CONTINUED)", "Evaluate", "data", "from", "Actos", "507", ">", "Evaluate", "data", "to", "support", "Amy", "Hagaman", "August", "5", "ustification", "to", "proceed", "with",...	[ [ 174, 101, 207, 115 ], [ 385, 101, 437, 115 ], [ 534, 101, 576, 116 ], [ 580, 101, 705, 117 ], [ 768, 102, 805, 116 ], [ 808, 103, 850, 116 ], [ 90, 122, 104, 135 ], [ 107...	who is the lead responsibility for developing additional monitoring plan for actos 508	Amy Hagaman
535	[ "Task", "Notes", "Lead", "Responsibility", "Due", "Date", "4.", "PEDIATRIC", "STUDIES", "(CONTINUED)", "Evaluate", "data", "from", "Actos", "507", ">", "Evaluate", "data", "to", "support", "Amy", "Hagaman", "August", "5", "ustification", "to", "proceed", "with",...	[ [ 174, 101, 207, 115 ], [ 385, 101, 437, 115 ], [ 534, 101, 576, 116 ], [ 580, 101, 705, 117 ], [ 768, 102, 805, 116 ], [ 808, 103, 850, 116 ], [ 90, 122, 104, 135 ], [ 107...	what is the due date for "draft justification for actos 508" ?	August 12
535	[ "Task", "Notes", "Lead", "Responsibility", "Due", "Date", "4.", "PEDIATRIC", "STUDIES", "(CONTINUED)", "Evaluate", "data", "from", "Actos", "507", ">", "Evaluate", "data", "to", "support", "Amy", "Hagaman", "August", "5", "ustification", "to", "proceed", "with",...	[ [ 174, 101, 207, 115 ], [ 385, 101, 437, 115 ], [ 534, 101, 576, 116 ], [ 580, 101, 705, 117 ], [ 768, 102, 805, 116 ], [ 808, 103, 850, 116 ], [ 90, 122, 104, 135 ], [ 107...	when was this last updated ?	August 1, 2002
535	[ "Task", "Notes", "Lead", "Responsibility", "Due", "Date", "4.", "PEDIATRIC", "STUDIES", "(CONTINUED)", "Evaluate", "data", "from", "Actos", "507", ">", "Evaluate", "data", "to", "support", "Amy", "Hagaman", "August", "5", "ustification", "to", "proceed", "with",...	[ [ 174, 101, 207, 115 ], [ 385, 101, 437, 115 ], [ 534, 101, 576, 116 ], [ 580, 101, 705, 117 ], [ 768, 102, 805, 116 ], [ 808, 103, 850, 116 ], [ 90, 122, 104, 135 ], [ 107...	Who is the lead responsible person for draft justification for actos 508?	Amy Hagaman/Alfonso Perez
543	[ "Ms.", "Wakamatsu,", "Assistant", "manager,", "Dept.", "Strategic", "Development,", "et", "al.", "Attachment:", "NDA", "schedule", "for", "each", "project", "approved", "on", "the", "5th", "GDC", "1.", "Openings", "Remarks", "Dr.", "Kitazawa", "made", "opening", ...	[ [ 107, 142, 132, 152 ], [ 134, 142, 218, 152 ], [ 220, 142, 280, 153 ], [ 282, 142, 346, 153 ], [ 348, 142, 385, 153 ], [ 387, 142, 446, 153 ], [ 448, 141, 540, 153 ], [ 54...	Which is the core organization of Takeda pharmaceutical Company?	Pharmaceutical development Division
543	[ "Ms.", "Wakamatsu,", "Assistant", "manager,", "Dept.", "Strategic", "Development,", "et", "al.", "Attachment:", "NDA", "schedule", "for", "each", "project", "approved", "on", "the", "5th", "GDC", "1.", "Openings", "Remarks", "Dr.", "Kitazawa", "made", "opening", ...	[ [ 107, 142, 132, 152 ], [ 134, 142, 218, 152 ], [ 220, 142, 280, 153 ], [ 282, 142, 346, 153 ], [ 348, 142, 385, 153 ], [ 387, 142, 446, 153 ], [ 448, 141, 540, 153 ], [ 54...	Who made the opening remarks ?	Dr. Kitazawa
543	[ "Ms.", "Wakamatsu,", "Assistant", "manager,", "Dept.", "Strategic", "Development,", "et", "al.", "Attachment:", "NDA", "schedule", "for", "each", "project", "approved", "on", "the", "5th", "GDC", "1.", "Openings", "Remarks", "Dr.", "Kitazawa", "made", "opening", ...	[ [ 107, 142, 132, 152 ], [ 134, 142, 218, 152 ], [ 220, 142, 280, 153 ], [ 282, 142, 346, 153 ], [ 348, 142, 385, 153 ], [ 387, 142, 446, 153 ], [ 448, 141, 540, 153 ], [ 54...	When is the clinical expert meeting scheduled?	for October 1 and 2.
539	[ "Actos", "Pediatric", "Working", "Group", "Date:", "20", "April", "2006", "Time:", "4:00pm", "-", "5:00pm", "Meeting", "Minutes", "Place:", "Meeting", "Room", "403", "Attendees", "Attendees", "Alfonso", "Perez", "-", "Clinical", "Karen", "Kaluzny", "-", "Project...	[ [ 57, 76, 111, 92 ], [ 114, 77, 197, 92 ], [ 200, 76, 279, 93 ], [ 282, 76, 341, 93 ], [ 410, 76, 460, 91 ], [ 462, 77, 487, 91 ], [ 489, 77, 537, 91 ], [ 539, 76, ...	what is the date mentioned in the given information ?	20 April 2006
539	[ "Actos", "Pediatric", "Working", "Group", "Date:", "20", "April", "2006", "Time:", "4:00pm", "-", "5:00pm", "Meeting", "Minutes", "Place:", "Meeting", "Room", "403", "Attendees", "Attendees", "Alfonso", "Perez", "-", "Clinical", "Karen", "Kaluzny", "-", "Project...	[ [ 57, 76, 111, 92 ], [ 114, 77, 197, 92 ], [ 200, 76, 279, 93 ], [ 282, 76, 341, 93 ], [ 410, 76, 460, 91 ], [ 462, 77, 487, 91 ], [ 489, 77, 537, 91 ], [ 539, 76, ...	What is the meeting time mentioned here?	4:00pm - 5:00pm

503

[ "DEPARTMENT", "OF", "HEALTH", "&", "HUMAN", "SERVICES", "Public", "Health", "Service", "Food", "and", "Drug", "Administration", "Rockville,", "MD", "20857", "NDA", "21-073/S-026", "DISCIPLINE", "REVIEW", "LETTER", "Takeda", "Global", "Research", "&", "Development", ...

[ [ 188, 91, 314, 106 ], [ 316, 91, 341, 107 ], [ 344, 91, 417, 107 ], [ 423, 91, 437, 107 ], [ 440, 91, 506, 107 ], [ 512, 91, 602, 107 ], [ 678, 85, 716, 97 ], [ 718, 8...

What kind of a letter is this ?

DISCIPLINE REVIEW LETTER

502

[ "Lilly", "Eli", "Lilly", "and", "Company", "Pharmaceutical", "Division", "Lilly", "Corporate", "Center", "Indianapolis,", "Indiana", "46285", "317.276.2090", "August", "16,", "1999", "Alan", "D.", "Mackenzie", "Senior", "Vice", "President,", "Sales", "and", "Marketi...

[ [ 483, 67, 540, 96 ], [ 404, 112, 429, 126 ], [ 432, 113, 471, 126 ], [ 475, 113, 509, 126 ], [ 515, 113, 605, 127 ], [ 431, 127, 526, 136 ], [ 528, 127, 574, 137 ], [ 436,...

Which two companies have agreed to amend the Co-Promotion Agreement?

Takeda Pharmaceuticals America, Inc. ("TPA") and Eli Lilly and Company ("Lilly")

504

[ "EXHIBIT", "Ant", "THE", "UPJOHN", "COMPANY", "KALAMAZOO.", "MICHIGAN", "49001", "0199.", "U.5.4.", "TELEPHONE:", "(616)", "323", "4000", "J.", "R.", "MITCHELL,", "MD.,", "P.", "D.", "Vice", "Chairman", "of", "the", "doand", "PAR.", "September", "21,", "1993",...

[ [ 463, 23, 544, 39 ], [ 767, 82, 832, 108 ], [ 190, 126, 264, 152 ], [ 287, 127, 452, 153 ], [ 477, 124, 698, 153 ], [ 188, 156, 262, 168 ], [ 265, 158, 319, 169 ], [ 322, ...

What is the name of the company?

THE UPJOHN COMPANY

504

[ "EXHIBIT", "Ant", "THE", "UPJOHN", "COMPANY", "KALAMAZOO.", "MICHIGAN", "49001", "0199.", "U.5.4.", "TELEPHONE:", "(616)", "323", "4000", "J.", "R.", "MITCHELL,", "MD.,", "P.", "D.", "Vice", "Chairman", "of", "the", "doand", "PAR.", "September", "21,", "1993",...

[ [ 463, 23, 544, 39 ], [ 767, 82, 832, 108 ], [ 190, 126, 264, 152 ], [ 287, 127, 452, 153 ], [ 477, 124, 698, 153 ], [ 188, 156, 262, 168 ], [ 265, 158, 319, 169 ], [ 322, ...

What is the date mentioned?

September 21, 1993

504

[ "EXHIBIT", "Ant", "THE", "UPJOHN", "COMPANY", "KALAMAZOO.", "MICHIGAN", "49001", "0199.", "U.5.4.", "TELEPHONE:", "(616)", "323", "4000", "J.", "R.", "MITCHELL,", "MD.,", "P.", "D.", "Vice", "Chairman", "of", "the", "doand", "PAR.", "September", "21,", "1993",...

[ [ 463, 23, 544, 39 ], [ 767, 82, 832, 108 ], [ 190, 126, 264, 152 ], [ 287, 127, 452, 153 ], [ 477, 124, 698, 153 ], [ 188, 156, 262, 168 ], [ 265, 158, 319, 169 ], [ 322, ...

To whom is this letter addressed?

Tai Matsuzawa, Ph.D.

504

[ "EXHIBIT", "Ant", "THE", "UPJOHN", "COMPANY", "KALAMAZOO.", "MICHIGAN", "49001", "0199.", "U.5.4.", "TELEPHONE:", "(616)", "323", "4000", "J.", "R.", "MITCHELL,", "MD.,", "P.", "D.", "Vice", "Chairman", "of", "the", "doand", "PAR.", "September", "21,", "1993",...

[ [ 463, 23, 544, 39 ], [ 767, 82, 832, 108 ], [ 190, 126, 264, 152 ], [ 287, 127, 452, 153 ], [ 477, 124, 698, 153 ], [ 188, 156, 262, 168 ], [ 265, 158, 319, 169 ], [ 322, ...

As a consequence of the decision Upjohn must decline participation with which company?

Takeda

507

[ "aked", "TAKEDA", "PHARMACEUTICALS", "NORTH", "AMERICA", "INC.", "Case", "Number", "Two:", "A", "79-year-old", "female,", "enrolled", "in", "the", "study", "for", "200", "days,", "was", "hospitalized", "for", "a", "bladder", "biopsy", "for", "possible", "recurre...

[ [ 431, 60, 486, 75 ], [ 322, 87, 365, 100 ], [ 368, 86, 477, 99 ], [ 480, 86, 519, 99 ], [ 522, 87, 572, 99 ], [ 575, 87, 600, 99 ], [ 135, 118, 171, 132 ], [ 174, 117,...

A 79-year-old female was enrolled in the study for how many days?

200 days

507

[ "aked", "TAKEDA", "PHARMACEUTICALS", "NORTH", "AMERICA", "INC.", "Case", "Number", "Two:", "A", "79-year-old", "female,", "enrolled", "in", "the", "study", "for", "200", "days,", "was", "hospitalized", "for", "a", "bladder", "biopsy", "for", "possible", "recurre...

[ [ 431, 60, 486, 75 ], [ 322, 87, 365, 100 ], [ 368, 86, 477, 99 ], [ 480, 86, 519, 99 ], [ 522, 87, 572, 99 ], [ 575, 87, 600, 99 ], [ 135, 118, 171, 132 ], [ 174, 117,...

The patient had a history of bladder cancer since when?

1996

509

[ "Dr.", "Ruppel", "October", "25", "Page", "2", "of", "2", "We", "are", "sorry", "for", "having", "had", "a", "delay", "in", "responding", "to", "your", "request", "because", "of", "my", "absence", "on", "business", "abroad.", "Sincerely", "yours,", "TAKEDA...

[ [ 198, 124, 233, 136 ], [ 241, 124, 304, 137 ], [ 201, 136, 274, 150 ], [ 285, 135, 305, 148 ], [ 200, 150, 242, 163 ], [ 252, 150, 264, 162 ], [ 272, 149, 296, 162 ], [ 30...

Who is the general manager of International development Dept. of Takeda Chemical Industires, Ltd.?

K. Kitazawa, Ph. D.

507

[ "aked", "TAKEDA", "PHARMACEUTICALS", "NORTH", "AMERICA", "INC.", "Case", "Number", "Two:", "A", "79-year-old", "female,", "enrolled", "in", "the", "study", "for", "200", "days,", "was", "hospitalized", "for", "a", "bladder", "biopsy", "for", "possible", "recurre...

[ [ 431, 60, 486, 75 ], [ 322, 87, 365, 100 ], [ 368, 86, 477, 99 ], [ 480, 86, 519, 99 ], [ 522, 87, 572, 99 ], [ 575, 87, 600, 99 ], [ 135, 118, 171, 132 ], [ 174, 117,...

Who is the writer of the document?

Janet L. Haskins

507

[ "aked", "TAKEDA", "PHARMACEUTICALS", "NORTH", "AMERICA", "INC.", "Case", "Number", "Two:", "A", "79-year-old", "female,", "enrolled", "in", "the", "study", "for", "200", "days,", "was", "hospitalized", "for", "a", "bladder", "biopsy", "for", "possible", "recurre...

[ [ 431, 60, 486, 75 ], [ 322, 87, 365, 100 ], [ 368, 86, 477, 99 ], [ 480, 86, 519, 99 ], [ 522, 87, 572, 99 ], [ 575, 87, 600, 99 ], [ 135, 118, 171, 132 ], [ 174, 117,...

The woman had a positive history of what?

tobacco use

509

[ "Dr.", "Ruppel", "October", "25", "Page", "2", "of", "2", "We", "are", "sorry", "for", "having", "had", "a", "delay", "in", "responding", "to", "your", "request", "because", "of", "my", "absence", "on", "business", "abroad.", "Sincerely", "yours,", "TAKEDA...

[ [ 198, 124, 233, 136 ], [ 241, 124, 304, 137 ], [ 201, 136, 274, 150 ], [ 285, 135, 305, 148 ], [ 200, 150, 242, 163 ], [ 252, 150, 264, 162 ], [ 272, 149, 296, 162 ], [ 30...

what is the name of the industry ?

TAKEDA CHEMICAL INDUSTRIES, LTD.

509

[ "Dr.", "Ruppel", "October", "25", "Page", "2", "of", "2", "We", "are", "sorry", "for", "having", "had", "a", "delay", "in", "responding", "to", "your", "request", "because", "of", "my", "absence", "on", "business", "abroad.", "Sincerely", "yours,", "TAKEDA...

[ [ 198, 124, 233, 136 ], [ 241, 124, 304, 137 ], [ 201, 136, 274, 150 ], [ 285, 135, 305, 148 ], [ 200, 150, 242, 163 ], [ 252, 150, 264, 162 ], [ 272, 149, 296, 162 ], [ 30...

How many pages are there in total?

2

509

[ "Dr.", "Ruppel", "October", "25", "Page", "2", "of", "2", "We", "are", "sorry", "for", "having", "had", "a", "delay", "in", "responding", "to", "your", "request", "because", "of", "my", "absence", "on", "business", "abroad.", "Sincerely", "yours,", "TAKEDA...

[ [ 198, 124, 233, 136 ], [ 241, 124, 304, 137 ], [ 201, 136, 274, 150 ], [ 285, 135, 305, 148 ], [ 200, 150, 242, 163 ], [ 252, 150, 264, 162 ], [ 272, 149, 296, 162 ], [ 30...

what is the month and date mentioned in this letter, at the top ?

October 25

511

[ "Takeda", "Pharmaceuticals", "U.S.A.,", "Inc.", "Address", ":", "One", "Takeda", "Parkway,", "Deerfield,", "IL", "60015,", "U.S.A", "Tel", ":", "+1-224-554-5586", "E-mail:", "stacey.calahan@takeda.com", "(Copy)", "Kazuyuki", "Kisaka", "Senior", "Director", "IP", "Lice...

[ [ 147, 88, 196, 103 ], [ 200, 88, 318, 103 ], [ 321, 89, 377, 104 ], [ 380, 89, 411, 105 ], [ 145, 109, 204, 123 ], [ 208, 109, 216, 123 ], [ 219, 109, 251, 123 ], [ 254, ...

By whom is this document written?

Stacey Dixon Calahan

514

[ "FROM", "HERETAN", "DEMAS", "FAX05-6204-2943", "19994", "18218", "(*)", "21", "31/21", ":", "28/x56:480:", "941295", "F", "1", "Takeda", "Chemical", "Industries,", "Ltd.", "Takeda", "Product", "Planning", "&", "Management", "Dept.,", "International", "Division", "...

[ [ 114, 37, 145, 48 ], [ 151, 37, 207, 48 ], [ 213, 37, 262, 48 ], [ 269, 36, 386, 49 ], [ 478, 35, 519, 48 ], [ 525, 36, 562, 48 ], [ 565, 36, 583, 49 ], [ 586, 37, ...

What is the date mentioned?

January 21, 1999

514

[ "FROM", "HERETAN", "DEMAS", "FAX05-6204-2943", "19994", "18218", "(*)", "21", "31/21", ":", "28/x56:480:", "941295", "F", "1", "Takeda", "Chemical", "Industries,", "Ltd.", "Takeda", "Product", "Planning", "&", "Management", "Dept.,", "International", "Division", "...

[ [ 114, 37, 145, 48 ], [ 151, 37, 207, 48 ], [ 213, 37, 262, 48 ], [ 269, 36, 386, 49 ], [ 478, 35, 519, 48 ], [ 525, 36, 562, 48 ], [ 565, 36, 583, 49 ], [ 586, 37, ...

To whom is this document addressed?

Mr. Larry Ellingson

513

[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved;", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...

[ [ 172, 64, 268, 77 ], [ 271, 64, 290, 76 ], [ 292, 64, 348, 76 ], [ 352, 64, 382, 76 ], [ 385, 63, 435, 76 ], [ 440, 63, 509, 77 ], [ 627, 61, 654, 72 ], [ 658, 60, ...

to which department it belongs to ?

DEPARTMENT OF HEALTH AND HUMAN SERVICES

514

[ "FROM", "HERETAN", "DEMAS", "FAX05-6204-2943", "19994", "18218", "(*)", "21", "31/21", ":", "28/x56:480:", "941295", "F", "1", "Takeda", "Chemical", "Industries,", "Ltd.", "Takeda", "Product", "Planning", "&", "Management", "Dept.,", "International", "Division", "...

[ [ 114, 37, 145, 48 ], [ 151, 37, 207, 48 ], [ 213, 37, 262, 48 ], [ 269, 36, 386, 49 ], [ 478, 35, 519, 48 ], [ 525, 36, 562, 48 ], [ 565, 36, 583, 49 ], [ 586, 37, ...

By whom is this document written?

Kunio Iwatani

513

[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved;", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...

[ [ 172, 64, 268, 77 ], [ 271, 64, 290, 76 ], [ 292, 64, 348, 76 ], [ 352, 64, 382, 76 ], [ 385, 63, 435, 76 ], [ 440, 63, 509, 77 ], [ 627, 61, 654, 72 ], [ 658, 60, ...

what is the date of submission?

11/18/2002

513

[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved;", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...

[ [ 172, 64, 268, 77 ], [ 271, 64, 290, 76 ], [ 292, 64, 348, 76 ], [ 352, 64, 382, 76 ], [ 385, 63, 435, 76 ], [ 440, 63, 509, 77 ], [ 627, 61, 654, 72 ], [ 658, 60, ...

what is the telephone number (include area code)?

847-383-3739

513

[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved;", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...

[ [ 172, 64, 268, 77 ], [ 271, 64, 290, 76 ], [ 292, 64, 348, 76 ], [ 352, 64, 382, 76 ], [ 385, 63, 435, 76 ], [ 440, 63, 509, 77 ], [ 627, 61, 654, 72 ], [ 658, 60, ...

What is the serial number mentioned in the form?

5 0 1

513

[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved;", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...

[ [ 172, 64, 268, 77 ], [ 271, 64, 290, 76 ], [ 292, 64, 348, 76 ], [ 352, 64, 382, 76 ], [ 385, 63, 435, 76 ], [ 440, 63, 509, 77 ], [ 627, 61, 654, 72 ], [ 658, 60, ...

what is the expiration date ?

November 30, 2002

513

[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved;", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...

[ [ 172, 64, 268, 77 ], [ 271, 64, 290, 76 ], [ 292, 64, 348, 76 ], [ 352, 64, 382, 76 ], [ 385, 63, 435, 76 ], [ 440, 63, 509, 77 ], [ 627, 61, 654, 72 ], [ 658, 60, ...

what is the name of the sponsor ?

Takeda Pharmaceuticals North America, Inc.

515

[ "Takeda", "In", "light", "of", "age-related", "risks", "(especially", "bladder", "cancer,", "fractures", "and", "heart", "failure),", "the", "balance", "of", "benefits", "and", "risks", "should", "be", "considered", "carefully", "both", "before", "and", "during", ...

[ [ 144, 60, 230, 83 ], [ 107, 109, 122, 122 ], [ 125, 109, 158, 123 ], [ 162, 109, 178, 123 ], [ 181, 110, 260, 123 ], [ 264, 110, 298, 124 ], [ 301, 110, 380, 124 ], [ 382,...

what has to be investigated before starting pioglitazone therapy?

any macroscopic haematuria

515

[ "Takeda", "In", "light", "of", "age-related", "risks", "(especially", "bladder", "cancer,", "fractures", "and", "heart", "failure),", "the", "balance", "of", "benefits", "and", "risks", "should", "be", "considered", "carefully", "both", "before", "and", "during", ...

[ [ 144, 60, 230, 83 ], [ 107, 109, 122, 122 ], [ 125, 109, 158, 123 ], [ 162, 109, 178, 123 ], [ 181, 110, 260, 123 ], [ 264, 110, 298, 124 ], [ 301, 110, 380, 124 ], [ 382,...

what has been experienced commonly in patients taking actos in combination with insulin?

Heart failure

517

[ "compensable.", "Payment", "will", "be", "made", "within", "thirty", "(30)", "days", "of", "TURD's", "receipt", "from", "Institution", "of", "invoices", "meeting", "the", "foregoing", "requirements.", "Payment", "shall", "be", "made", "payable", "as", "follows:", ...

[ [ 175, 76, 278, 90 ], [ 281, 76, 345, 90 ], [ 348, 76, 377, 90 ], [ 380, 76, 397, 90 ], [ 400, 76, 441, 90 ], [ 444, 76, 490, 90 ], [ 493, 76, 534, 90 ], [ 537, 76, ...

Which foundation is mentioned in this document?

Cleveland Clinic Foundation

517

[ "compensable.", "Payment", "will", "be", "made", "within", "thirty", "(30)", "days", "of", "TURD's", "receipt", "from", "Institution", "of", "invoices", "meeting", "the", "foregoing", "requirements.", "Payment", "shall", "be", "made", "payable", "as", "follows:", ...

[ [ 175, 76, 278, 90 ], [ 281, 76, 345, 90 ], [ 348, 76, 377, 90 ], [ 380, 76, 397, 90 ], [ 400, 76, 441, 90 ], [ 444, 76, 490, 90 ], [ 493, 76, 534, 90 ], [ 537, 76, ...

Under which department , The Cleveland Clinic Foundation operates?

Department of Cardiovascular Medicine

514

[ "FROM", "HERETAN", "DEMAS", "FAX05-6204-2943", "19994", "18218", "(*)", "21", "31/21", ":", "28/x56:480:", "941295", "F", "1", "Takeda", "Chemical", "Industries,", "Ltd.", "Takeda", "Product", "Planning", "&", "Management", "Dept.,", "International", "Division", "...

[ [ 114, 37, 145, 48 ], [ 151, 37, 207, 48 ], [ 213, 37, 262, 48 ], [ 269, 36, 386, 49 ], [ 478, 35, 519, 48 ], [ 525, 36, 562, 48 ], [ 565, 36, 583, 49 ], [ 586, 37, ...

What is written in big bold letters at the bottom?

DALY 19

515

[ "Takeda", "In", "light", "of", "age-related", "risks", "(especially", "bladder", "cancer,", "fractures", "and", "heart", "failure),", "the", "balance", "of", "benefits", "and", "risks", "should", "be", "considered", "carefully", "both", "before", "and", "during", ...

[ [ 144, 60, 230, 83 ], [ 107, 109, 122, 122 ], [ 125, 109, 158, 123 ], [ 162, 109, 178, 123 ], [ 181, 110, 260, 123 ], [ 264, 110, 298, 124 ], [ 301, 110, 380, 124 ], [ 382,...

Which medicine is used to treat type 2 diabetes mellitus?

Actos/Competact

515

[ "Takeda", "In", "light", "of", "age-related", "risks", "(especially", "bladder", "cancer,", "fractures", "and", "heart", "failure),", "the", "balance", "of", "benefits", "and", "risks", "should", "be", "considered", "carefully", "both", "before", "and", "during", ...

[ [ 144, 60, 230, 83 ], [ 107, 109, 122, 122 ], [ 125, 109, 158, 123 ], [ 162, 109, 178, 123 ], [ 181, 110, 260, 123 ], [ 264, 110, 298, 124 ], [ 301, 110, 380, 124 ], [ 382,...

How many cases of bladder cancer from 12506 patients were reported?

19 cases

517

[ "compensable.", "Payment", "will", "be", "made", "within", "thirty", "(30)", "days", "of", "TURD's", "receipt", "from", "Institution", "of", "invoices", "meeting", "the", "foregoing", "requirements.", "Payment", "shall", "be", "made", "payable", "as", "follows:", ...

[ [ 175, 76, 278, 90 ], [ 281, 76, 345, 90 ], [ 348, 76, 377, 90 ], [ 380, 76, 397, 90 ], [ 400, 76, 441, 90 ], [ 444, 76, 490, 90 ], [ 493, 76, 534, 90 ], [ 537, 76, ...

What is the PO Box number?

931535

518

[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved:", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...

[ [ 210, 85, 294, 97 ], [ 298, 85, 314, 96 ], [ 317, 85, 369, 96 ], [ 373, 84, 398, 95 ], [ 401, 84, 448, 96 ], [ 452, 83, 510, 96 ], [ 621, 81, 646, 92 ], [ 650, 81, ...

what is the IND mumber (if previously assigned ) ?

33,729

518

[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved:", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...

[ [ 210, 85, 294, 97 ], [ 298, 85, 314, 96 ], [ 317, 85, 369, 96 ], [ 373, 84, 398, 95 ], [ 401, 84, 448, 96 ], [ 452, 83, 510, 96 ], [ 621, 81, 646, 92 ], [ 650, 81, ...

What is the serial number mentioned in the form?

4 9 7

518

[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved:", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...

[ [ 210, 85, 294, 97 ], [ 298, 85, 314, 96 ], [ 317, 85, 369, 96 ], [ 373, 84, 398, 95 ], [ 401, 84, 448, 96 ], [ 452, 83, 510, 96 ], [ 621, 81, 646, 92 ], [ 650, 81, ...

what is the date of submission ?

11/1/02

518

[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved:", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...

[ [ 210, 85, 294, 97 ], [ 298, 85, 314, 96 ], [ 317, 85, 369, 96 ], [ 373, 84, 398, 95 ], [ 401, 84, 448, 96 ], [ 452, 83, 510, 96 ], [ 621, 81, 646, 92 ], [ 650, 81, ...

what is the Name(s) of drug (include all available names: Trade , Generic, Chemical, Code)?

ACTOS (pioglitazone HCI)

517

[ "compensable.", "Payment", "will", "be", "made", "within", "thirty", "(30)", "days", "of", "TURD's", "receipt", "from", "Institution", "of", "invoices", "meeting", "the", "foregoing", "requirements.", "Payment", "shall", "be", "made", "payable", "as", "follows:", ...

[ [ 175, 76, 278, 90 ], [ 281, 76, 345, 90 ], [ 348, 76, 377, 90 ], [ 380, 76, 397, 90 ], [ 400, 76, 441, 90 ], [ 444, 76, 490, 90 ], [ 493, 76, 534, 90 ], [ 537, 76, ...

What is the Tax ID mentioned in this document?

34-0714585

518

[ "DEPARTMENT", "OF", "HEALTH", "AND", "HUMAN", "SERVICES", "Form", "Approved:", "OMB", "No.", "0910-0014", "PUBLIC", "HEALTH", "SERVICE", "Expiration", "Date:", "November", "30,", "2002", "FOOD", "AND", "DRUG", "ADMINISTRATION", "See", "OMB", "Statement", "on", "...

[ [ 210, 85, 294, 97 ], [ 298, 85, 314, 96 ], [ 317, 85, 369, 96 ], [ 373, 84, 398, 95 ], [ 401, 84, 448, 96 ], [ 452, 83, 510, 96 ], [ 621, 81, 646, 92 ], [ 650, 81, ...

what is the form approved : OMB No

0910-0014

505

[ "Takeda", "19", "January", "2012", "Direct", "Healthcare", "Professional", "Communication", "on", "pioglitazone", "and", "a", "small", "increased", "risk", "of.", "Urinary", "Bladder", "Cancer.", "Dear", "Healthcare", "Professional,", "Summary", "Following", "the", ...

[ [ 145, 59, 229, 81 ], [ 682, 109, 702, 122 ], [ 715, 109, 780, 122 ], [ 782, 109, 820, 122 ], [ 107, 140, 155, 153 ], [ 158, 140, 243, 153 ], [ 245, 141, 341, 154 ], [ 344,...

What is the word written in bold on the top of the document?

Takeda

505

[ "Takeda", "19", "January", "2012", "Direct", "Healthcare", "Professional", "Communication", "on", "pioglitazone", "and", "a", "small", "increased", "risk", "of.", "Urinary", "Bladder", "Cancer.", "Dear", "Healthcare", "Professional,", "Summary", "Following", "the", ...

[ [ 145, 59, 229, 81 ], [ 682, 109, 702, 122 ], [ 715, 109, 780, 122 ], [ 782, 109, 820, 122 ], [ 107, 140, 155, 153 ], [ 158, 140, 243, 153 ], [ 245, 141, 341, 154 ], [ 344,...

What is the date mentioned?

19th January 2012

519

[ "DEPARTMENT", "OF", "HEALTH", "&", "HUMAN", "SERVICES", "Public", "Health", "Service", "Food", "and", "Drug", "Administration", "Rockville,", "MD", "20857", "IND", "33,729", "RECEIVED", "REGULATORY", "AFFAIRS", "DEPARTMENT", "Takeda", "Pharmaceuticals", "North", "Am...

[ [ 170, 94, 272, 105 ], [ 274, 94, 295, 105 ], [ 297, 94, 357, 105 ], [ 363, 93, 373, 105 ], [ 377, 93, 430, 105 ], [ 434, 92, 504, 105 ], [ 662, 92, 698, 102 ], [ 700, ...

what is the name of pharmaceuticals ?

Takeda Pharmaceuticals North America, Inc.

519

[ "DEPARTMENT", "OF", "HEALTH", "&", "HUMAN", "SERVICES", "Public", "Health", "Service", "Food", "and", "Drug", "Administration", "Rockville,", "MD", "20857", "IND", "33,729", "RECEIVED", "REGULATORY", "AFFAIRS", "DEPARTMENT", "Takeda", "Pharmaceuticals", "North", "Am...

[ [ 170, 94, 272, 105 ], [ 274, 94, 295, 105 ], [ 297, 94, 357, 105 ], [ 363, 93, 373, 105 ], [ 377, 93, 430, 105 ], [ 434, 92, 504, 105 ], [ 662, 92, 698, 102 ], [ 700, ...

to whom this letter is written ?

Janet L. Haskins

519

[ "DEPARTMENT", "OF", "HEALTH", "&", "HUMAN", "SERVICES", "Public", "Health", "Service", "Food", "and", "Drug", "Administration", "Rockville,", "MD", "20857", "IND", "33,729", "RECEIVED", "REGULATORY", "AFFAIRS", "DEPARTMENT", "Takeda", "Pharmaceuticals", "North", "Am...

[ [ 170, 94, 272, 105 ], [ 274, 94, 295, 105 ], [ 297, 94, 357, 105 ], [ 363, 93, 373, 105 ], [ 377, 93, 430, 105 ], [ 434, 92, 504, 105 ], [ 662, 92, 698, 102 ], [ 700, ...

When did Regulatory affairs department receive this letter?

JUN 16 2003

505

[ "Takeda", "19", "January", "2012", "Direct", "Healthcare", "Professional", "Communication", "on", "pioglitazone", "and", "a", "small", "increased", "risk", "of.", "Urinary", "Bladder", "Cancer.", "Dear", "Healthcare", "Professional,", "Summary", "Following", "the", ...

[ [ 145, 59, 229, 81 ], [ 682, 109, 702, 122 ], [ 715, 109, 780, 122 ], [ 782, 109, 820, 122 ], [ 107, 140, 155, 153 ], [ 158, 140, 243, 153 ], [ 245, 141, 341, 154 ], [ 344,...

To whom was this letter written?

Healthcare Professional

510

[ "3.", "Reports", "to", "any", "third", "party,", "including,", "but", "not", "limited", "to,", "RedBook,", "First", "Data", "Bank,", "Blue", "Book,", "Medi-Span,", "or", "other", "price", "reporting", "service,", "regarding", "prices", "for", "TPNA", "products;"...

[ [ 178, 134, 196, 146 ], [ 199, 134, 255, 146 ], [ 258, 134, 274, 146 ], [ 277, 135, 302, 146 ], [ 305, 135, 338, 147 ], [ 340, 135, 380, 147 ], [ 383, 135, 451, 147 ], [ 45...

What is the fifth point?

WAC and AWP generally;

510

[ "3.", "Reports", "to", "any", "third", "party,", "including,", "but", "not", "limited", "to,", "RedBook,", "First", "Data", "Bank,", "Blue", "Book,", "Medi-Span,", "or", "other", "price", "reporting", "service,", "regarding", "prices", "for", "TPNA", "products;"...

[ [ 178, 134, 196, 146 ], [ 199, 134, 255, 146 ], [ 258, 134, 274, 146 ], [ 277, 135, 302, 146 ], [ 305, 135, 338, 147 ], [ 340, 135, 380, 147 ], [ 383, 135, 451, 147 ], [ 45...

Education grants regarding which products?

TPNA

510

[ "3.", "Reports", "to", "any", "third", "party,", "including,", "but", "not", "limited", "to,", "RedBook,", "First", "Data", "Bank,", "Blue", "Book,", "Medi-Span,", "or", "other", "price", "reporting", "service,", "regarding", "prices", "for", "TPNA", "products;"...

[ [ 178, 134, 196, 146 ], [ 199, 134, 255, 146 ], [ 258, 134, 274, 146 ], [ 277, 135, 302, 146 ], [ 305, 135, 338, 147 ], [ 340, 135, 380, 147 ], [ 383, 135, 451, 147 ], [ 45...

What is the date this document was last printed?

11/30/2012

519

[ "DEPARTMENT", "OF", "HEALTH", "&", "HUMAN", "SERVICES", "Public", "Health", "Service", "Food", "and", "Drug", "Administration", "Rockville,", "MD", "20857", "IND", "33,729", "RECEIVED", "REGULATORY", "AFFAIRS", "DEPARTMENT", "Takeda", "Pharmaceuticals", "North", "Am...

[ [ 170, 94, 272, 105 ], [ 274, 94, 295, 105 ], [ 297, 94, 357, 105 ], [ 363, 93, 373, 105 ], [ 377, 93, 430, 105 ], [ 434, 92, 504, 105 ], [ 662, 92, 698, 102 ], [ 700, ...

To whom a copy of cover letter has to be sent ?

Ms. Jens Weber

510

[ "3.", "Reports", "to", "any", "third", "party,", "including,", "but", "not", "limited", "to,", "RedBook,", "First", "Data", "Bank,", "Blue", "Book,", "Medi-Span,", "or", "other", "price", "reporting", "service,", "regarding", "prices", "for", "TPNA", "products;"...

[ [ 178, 134, 196, 146 ], [ 199, 134, 255, 146 ], [ 258, 134, 274, 146 ], [ 277, 135, 302, 146 ], [ 305, 135, 338, 147 ], [ 340, 135, 380, 147 ], [ 383, 135, 451, 147 ], [ 45...

Which reimbursement for TPNA pharmaceutical products is generally given?

Medicare and Medicaid

512

[ "prior", "to", "such", "event", "or", "in", "connection", "therewith.", "Sections", "6.", "7,", "8,", "9.", "12.", "13,", "14.", "15", "and", "16", "of", "this", "Agreement", "shall", "survive", "the", "expiration", "of", "earlier", "termination", "of", "t...

[ [ 172, 77, 208, 89 ], [ 211, 77, 225, 90 ], [ 230, 77, 263, 90 ], [ 266, 77, 307, 90 ], [ 310, 76, 327, 90 ], [ 330, 76, 344, 90 ], [ 347, 76, 427, 90 ], [ 430, 76, ...

What is the designation of Alfonso T. Perez, M.D.?

Vice President, Clinical Research

512

[ "prior", "to", "such", "event", "or", "in", "connection", "therewith.", "Sections", "6.", "7,", "8,", "9.", "12.", "13,", "14.", "15", "and", "16", "of", "this", "Agreement", "shall", "survive", "the", "expiration", "of", "earlier", "termination", "of", "t...

[ [ 172, 77, 208, 89 ], [ 211, 77, 225, 90 ], [ 230, 77, 263, 90 ], [ 266, 77, 307, 90 ], [ 310, 76, 327, 90 ], [ 330, 76, 344, 90 ], [ 347, 76, 427, 90 ], [ 430, 76, ...

By whom was this agreement Agreed and Accepted?

Richard A. Rudick, M.D.

512

[ "prior", "to", "such", "event", "or", "in", "connection", "therewith.", "Sections", "6.", "7,", "8,", "9.", "12.", "13,", "14.", "15", "and", "16", "of", "this", "Agreement", "shall", "survive", "the", "expiration", "of", "earlier", "termination", "of", "t...

[ [ 172, 77, 208, 89 ], [ 211, 77, 225, 90 ], [ 230, 77, 263, 90 ], [ 266, 77, 307, 90 ], [ 310, 76, 327, 90 ], [ 330, 76, 344, 90 ], [ 347, 76, 427, 90 ], [ 430, 76, ...

What is the full form of FAR?

Federal Acquisitions Regulation

520

[ "IND", "33,729", "Page", "2", "Correspondence", "to", "this", "IND", "can", "be", "sent", "to", "the", "following", "address:", "U.S.", "Postal", "Service/", "Courier/Overnight", "Mail:", "Food", "and", "Drug", "Administration", "Center", "for", "Drug", "Evaluat...

[ [ 143, 88, 172, 101 ], [ 178, 88, 226, 102 ], [ 144, 101, 177, 114 ], [ 180, 102, 188, 114 ], [ 145, 135, 253, 150 ], [ 256, 137, 272, 150 ], [ 275, 137, 301, 150 ], [ 304,...

What is the number written above TAK-INDNDA-01577086?

425

520

[ "IND", "33,729", "Page", "2", "Correspondence", "to", "this", "IND", "can", "be", "sent", "to", "the", "following", "address:", "U.S.", "Postal", "Service/", "Courier/Overnight", "Mail:", "Food", "and", "Drug", "Administration", "Center", "for", "Drug", "Evaluat...

[ [ 143, 88, 172, 101 ], [ 178, 88, 226, 102 ], [ 144, 101, 177, 114 ], [ 180, 102, 188, 114 ], [ 145, 135, 253, 150 ], [ 256, 137, 272, 150 ], [ 275, 137, 301, 150 ], [ 304,...

What is the contact number of Ms. Jena Weber, Regulatory Project Manager?

301-827-6422

520

[ "IND", "33,729", "Page", "2", "Correspondence", "to", "this", "IND", "can", "be", "sent", "to", "the", "following", "address:", "U.S.", "Postal", "Service/", "Courier/Overnight", "Mail:", "Food", "and", "Drug", "Administration", "Center", "for", "Drug", "Evaluat...

[ [ 143, 88, 172, 101 ], [ 178, 88, 226, 102 ], [ 144, 101, 177, 114 ], [ 180, 102, 188, 114 ], [ 145, 135, 253, 150 ], [ 256, 137, 272, 150 ], [ 275, 137, 301, 150 ], [ 304,...

What is the full form of ODE?

Office of Drug Evaluation

520

[ "IND", "33,729", "Page", "2", "Correspondence", "to", "this", "IND", "can", "be", "sent", "to", "the", "following", "address:", "U.S.", "Postal", "Service/", "Courier/Overnight", "Mail:", "Food", "and", "Drug", "Administration", "Center", "for", "Drug", "Evaluat...

[ [ 143, 88, 172, 101 ], [ 178, 88, 226, 102 ], [ 144, 101, 177, 114 ], [ 180, 102, 188, 114 ], [ 145, 135, 253, 150 ], [ 256, 137, 272, 150 ], [ 275, 137, 301, 150 ], [ 304,...

What is written above Page 2 on the top?

IND 33, 729

521

[ "FROM", "THE", "DESK", "OF:", "Timothy", "J.", "Gumbleton", "UNIT:", "7200", "BLOG", ":", "24-1", "EXT:", "5-7054", "PJ", "Daniels", "LSolanoff", "DATE:", "9/23/42", "PL", "Ruppel", "L", "Twelch", "Attached", "is", "a", "cozy", "of", "the", "letter", "from...

[ [ 268, 109, 333, 129 ], [ 350, 108, 394, 129 ], [ 269, 130, 328, 148 ], [ 339, 130, 378, 148 ], [ 440, 127, 547, 152 ], [ 557, 130, 595, 153 ], [ 600, 130, 734, 154 ], [ 26...

what is the unit mentioned in the letter ?

7200

521

[ "FROM", "THE", "DESK", "OF:", "Timothy", "J.", "Gumbleton", "UNIT:", "7200", "BLOG", ":", "24-1", "EXT:", "5-7054", "PJ", "Daniels", "LSolanoff", "DATE:", "9/23/42", "PL", "Ruppel", "L", "Twelch", "Attached", "is", "a", "cozy", "of", "the", "letter", "from...

[ [ 268, 109, 333, 129 ], [ 350, 108, 394, 129 ], [ 269, 130, 328, 148 ], [ 339, 130, 378, 148 ], [ 440, 127, 547, 152 ], [ 557, 130, 595, 153 ], [ 600, 130, 734, 154 ], [ 26...

what is the date mentioned

9/23/93

512

[ "prior", "to", "such", "event", "or", "in", "connection", "therewith.", "Sections", "6.", "7,", "8,", "9.", "12.", "13,", "14.", "15", "and", "16", "of", "this", "Agreement", "shall", "survive", "the", "expiration", "of", "earlier", "termination", "of", "t...

[ [ 172, 77, 208, 89 ], [ 211, 77, 225, 90 ], [ 230, 77, 263, 90 ], [ 266, 77, 307, 90 ], [ 310, 76, 327, 90 ], [ 330, 76, 344, 90 ], [ 347, 76, 427, 90 ], [ 430, 76, ...

What is the date of the signature of the chairman of the Division of clinical research?

5/8/07

521

[ "FROM", "THE", "DESK", "OF:", "Timothy", "J.", "Gumbleton", "UNIT:", "7200", "BLOG", ":", "24-1", "EXT:", "5-7054", "PJ", "Daniels", "LSolanoff", "DATE:", "9/23/42", "PL", "Ruppel", "L", "Twelch", "Attached", "is", "a", "cozy", "of", "the", "letter", "from...

[ [ 268, 109, 333, 129 ], [ 350, 108, 394, 129 ], [ 269, 130, 328, 148 ], [ 339, 130, 378, 148 ], [ 440, 127, 547, 152 ], [ 557, 130, 595, 153 ], [ 600, 130, 734, 154 ], [ 26...

Name of the first person in the To list?

PJ Daniels

503

[ "DEPARTMENT", "OF", "HEALTH", "&", "HUMAN", "SERVICES", "Public", "Health", "Service", "Food", "and", "Drug", "Administration", "Rockville,", "MD", "20857", "NDA", "21-073/S-026", "DISCIPLINE", "REVIEW", "LETTER", "Takeda", "Global", "Research", "&", "Development", ...

[ [ 188, 91, 314, 106 ], [ 316, 91, 341, 107 ], [ 344, 91, 417, 107 ], [ 423, 91, 437, 107 ], [ 440, 91, 506, 107 ], [ 512, 91, 602, 107 ], [ 678, 85, 716, 97 ], [ 718, 8...

When did Regulatory affairs department receive this letter?

Feb 19 2007

521

[ "FROM", "THE", "DESK", "OF:", "Timothy", "J.", "Gumbleton", "UNIT:", "7200", "BLOG", ":", "24-1", "EXT:", "5-7054", "PJ", "Daniels", "LSolanoff", "DATE:", "9/23/42", "PL", "Ruppel", "L", "Twelch", "Attached", "is", "a", "cozy", "of", "the", "letter", "from...

[ [ 268, 109, 333, 129 ], [ 350, 108, 394, 129 ], [ 269, 130, 328, 148 ], [ 339, 130, 378, 148 ], [ 440, 127, 547, 152 ], [ 557, 130, 595, 153 ], [ 600, 130, 734, 154 ], [ 26...

from whose desk this letter is written ?

Timothy J. Gumbleton

521

[ "FROM", "THE", "DESK", "OF:", "Timothy", "J.", "Gumbleton", "UNIT:", "7200", "BLOG", ":", "24-1", "EXT:", "5-7054", "PJ", "Daniels", "LSolanoff", "DATE:", "9/23/42", "PL", "Ruppel", "L", "Twelch", "Attached", "is", "a", "cozy", "of", "the", "letter", "from...

[ [ 268, 109, 333, 129 ], [ 350, 108, 394, 129 ], [ 269, 130, 328, 148 ], [ 339, 130, 378, 148 ], [ 440, 127, 547, 152 ], [ 557, 130, 595, 153 ], [ 600, 130, 734, 154 ], [ 26...

Whose letter's copy is attached?

DR. Mitchell

522

[ "..", "Encl.", "2", "Draft", "2", "/", "1", "1", "TAKEDA", "INTERNATIONAL", "COMMUNICATION", "Date", "February", "6,", "1996", "To", "Dr.", "K.", "Kitazawa", "General", "Manager", "International", "Development", "From", "T.", "Suzuki", "Senior", "Research", "H...

[ [ 36, 29, 47, 43 ], [ 50, 27, 111, 43 ], [ 120, 26, 130, 41 ], [ 416, 11, 600, 66 ], [ 769, 24, 791, 51 ], [ 790, 27, 806, 54 ], [ 805, 30, 822, 57 ], [ 822, 33, 83...

what is the date mentioned ?

February 6, 1996

522

[ "..", "Encl.", "2", "Draft", "2", "/", "1", "1", "TAKEDA", "INTERNATIONAL", "COMMUNICATION", "Date", "February", "6,", "1996", "To", "Dr.", "K.", "Kitazawa", "General", "Manager", "International", "Development", "From", "T.", "Suzuki", "Senior", "Research", "H...

[ [ 36, 29, 47, 43 ], [ 50, 27, 111, 43 ], [ 120, 26, 130, 41 ], [ 416, 11, 600, 66 ], [ 769, 24, 791, 51 ], [ 790, 27, 806, 54 ], [ 805, 30, 822, 57 ], [ 822, 33, 83...

to whom this letter is written ?

Dr. K. KItazawa

522

[ "..", "Encl.", "2", "Draft", "2", "/", "1", "1", "TAKEDA", "INTERNATIONAL", "COMMUNICATION", "Date", "February", "6,", "1996", "To", "Dr.", "K.", "Kitazawa", "General", "Manager", "International", "Development", "From", "T.", "Suzuki", "Senior", "Research", "H...

[ [ 36, 29, 47, 43 ], [ 50, 27, 111, 43 ], [ 120, 26, 130, 41 ], [ 416, 11, 600, 66 ], [ 769, 24, 791, 51 ], [ 790, 27, 806, 54 ], [ 805, 30, 822, 57 ], [ 822, 33, 83...

this letter is written by whom ?

T. Suzuki

522

[ "..", "Encl.", "2", "Draft", "2", "/", "1", "1", "TAKEDA", "INTERNATIONAL", "COMMUNICATION", "Date", "February", "6,", "1996", "To", "Dr.", "K.", "Kitazawa", "General", "Manager", "International", "Development", "From", "T.", "Suzuki", "Senior", "Research", "H...

[ [ 36, 29, 47, 43 ], [ 50, 27, 111, 43 ], [ 120, 26, 130, 41 ], [ 416, 11, 600, 66 ], [ 769, 24, 791, 51 ], [ 790, 27, 806, 54 ], [ 805, 30, 822, 57 ], [ 822, 33, 83...

Which laboratory is T. Suzuki associated with ?

Drug Safety Research Laboratories

524

[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:", "49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "001/006", "116", "TAKEDA", "CHEMICAL", "INDUSTRIES,", "LTD.", "Pharmaceutical", "Development", "Division", "1-1,", "Doshomachi...

[ [ 59, 8, 152, 18 ], [ 181, 8, 226, 18 ], [ 272, 8, 291, 18 ], [ 299, 8, 338, 17 ], [ 346, 8, 384, 18 ], [ 41, 18, 79, 29 ], [ 87, 18, 134, 29 ], [ 143, 18, 169, ...

what is the date mentioned in the letter

August 8, 2002

524

[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:", "49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "001/006", "116", "TAKEDA", "CHEMICAL", "INDUSTRIES,", "LTD.", "Pharmaceutical", "Development", "Division", "1-1,", "Doshomachi...

[ [ 59, 8, 152, 18 ], [ 181, 8, 226, 18 ], [ 272, 8, 291, 18 ], [ 299, 8, 338, 17 ], [ 346, 8, 384, 18 ], [ 41, 18, 79, 29 ], [ 87, 18, 134, 29 ], [ 143, 18, 169, ...

What is the name of the industry given here?

Takeda chemical industries, LTD .

524

[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:", "49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "001/006", "116", "TAKEDA", "CHEMICAL", "INDUSTRIES,", "LTD.", "Pharmaceutical", "Development", "Division", "1-1,", "Doshomachi...

[ [ 59, 8, 152, 18 ], [ 181, 8, 226, 18 ], [ 272, 8, 291, 18 ], [ 299, 8, 338, 17 ], [ 346, 8, 384, 18 ], [ 41, 18, 79, 29 ], [ 87, 18, 134, 29 ], [ 143, 18, 169, ...

to whom this letter is written ?

Dr. Claire Thom

524

[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:", "49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "001/006", "116", "TAKEDA", "CHEMICAL", "INDUSTRIES,", "LTD.", "Pharmaceutical", "Development", "Division", "1-1,", "Doshomachi...

[ [ 59, 8, 152, 18 ], [ 181, 8, 226, 18 ], [ 272, 8, 291, 18 ], [ 299, 8, 338, 17 ], [ 346, 8, 384, 18 ], [ 41, 18, 79, 29 ], [ 87, 18, 134, 29 ], [ 143, 18, 169, ...

what is the name mentioned in CC

Mr. S. Hamanaka

524

[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:", "49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "001/006", "116", "TAKEDA", "CHEMICAL", "INDUSTRIES,", "LTD.", "Pharmaceutical", "Development", "Division", "1-1,", "Doshomachi...

[ [ 59, 8, 152, 18 ], [ 181, 8, 226, 18 ], [ 272, 8, 291, 18 ], [ 299, 8, 338, 17 ], [ 346, 8, 384, 18 ], [ 41, 18, 79, 29 ], [ 87, 18, 134, 29 ], [ 143, 18, 169, ...

Who sent this letter?

Katsuhisa Saito

524

[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:", "49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "001/006", "116", "TAKEDA", "CHEMICAL", "INDUSTRIES,", "LTD.", "Pharmaceutical", "Development", "Division", "1-1,", "Doshomachi...

[ [ 59, 8, 152, 18 ], [ 181, 8, 226, 18 ], [ 272, 8, 291, 18 ], [ 299, 8, 338, 17 ], [ 346, 8, 384, 18 ], [ 41, 18, 79, 29 ], [ 87, 18, 134, 29 ], [ 143, 18, 169, ...

what is Ref: code mentioned ?

TPNA-TS-020808

526

[ "08/07/2002", "18:47", "06", "6204", "2244", ".", "2002'", "08/08", "21:50", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "2", "006/006", "6", "/", "6", "Discussion", "points", "to", "address", "the", "three", "key", "issues", "raised", "b...

[ [ 58, 11, 152, 21 ], [ 181, 10, 228, 21 ], [ 272, 10, 291, 21 ], [ 299, 10, 339, 21 ], [ 346, 11, 384, 21 ], [ 31, 21, 39, 31 ], [ 41, 21, 84, 31 ], [ 87, 21, 133, ...

What is the venue mentioned in the document?

TPNA, Chicago

526

[ "08/07/2002", "18:47", "06", "6204", "2244", ".", "2002'", "08/08", "21:50", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "2", "006/006", "6", "/", "6", "Discussion", "points", "to", "address", "the", "three", "key", "issues", "raised", "b...

[ [ 58, 11, 152, 21 ], [ 181, 10, 228, 21 ], [ 272, 10, 291, 21 ], [ 299, 10, 339, 21 ], [ 346, 11, 384, 21 ], [ 31, 21, 39, 31 ], [ 41, 21, 84, 31 ], [ 87, 21, 133, ...

What is the date mentioned in the document?

Monday, 12 and Tuesday, 13 August 2002

526

[ "08/07/2002", "18:47", "06", "6204", "2244", ".", "2002'", "08/08", "21:50", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "2", "006/006", "6", "/", "6", "Discussion", "points", "to", "address", "the", "three", "key", "issues", "raised", "b...

[ [ 58, 11, 152, 21 ], [ 181, 10, 228, 21 ], [ 272, 10, 291, 21 ], [ 299, 10, 339, 21 ], [ 346, 11, 384, 21 ], [ 31, 21, 39, 31 ], [ 41, 21, 84, 31 ], [ 87, 21, 133, ...

what is the fax number mentioned in the letter at the top?

06 6204 2244

527

[ "From:", "PLK", "RCC1", "Date", "and", "time", "10/27/93", "09", ":", "36:07", "To:", "PJDANIEL-", "-", "PW17", "PO", "PETER", "J.", "DANIELS", "CC:", "RJWELTER-", "-", "PW17", "PO", "RICHARD", "J.", "WELTER", "LTWELCH", "--RCC1", "LAWRENCE", "T", "WELCH",...

[ [ 54, 44, 102, 55 ], [ 111, 44, 138, 54 ], [ 202, 44, 239, 54 ], [ 464, 44, 503, 55 ], [ 512, 44, 541, 55 ], [ 551, 43, 587, 55 ], [ 625, 42, 701, 54 ], [ 710, 42, ...

what is the date and time mentioned ?

10/27/93 09:36:07

527

[ "From:", "PLK", "RCC1", "Date", "and", "time", "10/27/93", "09", ":", "36:07", "To:", "PJDANIEL-", "-", "PW17", "PO", "PETER", "J.", "DANIELS", "CC:", "RJWELTER-", "-", "PW17", "PO", "RICHARD", "J.", "WELTER", "LTWELCH", "--RCC1", "LAWRENCE", "T", "WELCH",...

[ [ 54, 44, 102, 55 ], [ 111, 44, 138, 54 ], [ 202, 44, 239, 54 ], [ 464, 44, 503, 55 ], [ 512, 44, 541, 55 ], [ 551, 43, 587, 55 ], [ 625, 42, 701, 54 ], [ 710, 42, ...

what is mentioned in the subject ?

Pioglitazone statement

527

[ "From:", "PLK", "RCC1", "Date", "and", "time", "10/27/93", "09", ":", "36:07", "To:", "PJDANIEL-", "-", "PW17", "PO", "PETER", "J.", "DANIELS", "CC:", "RJWELTER-", "-", "PW17", "PO", "RICHARD", "J.", "WELTER", "LTWELCH", "--RCC1", "LAWRENCE", "T", "WELCH",...

[ [ 54, 44, 102, 55 ], [ 111, 44, 138, 54 ], [ 202, 44, 239, 54 ], [ 464, 44, 503, 55 ], [ 512, 44, 541, 55 ], [ 551, 43, 587, 55 ], [ 625, 42, 701, 54 ], [ 710, 42, ...

To whom this email was send?

PETER J. DANIELS

527

[ "From:", "PLK", "RCC1", "Date", "and", "time", "10/27/93", "09", ":", "36:07", "To:", "PJDANIEL-", "-", "PW17", "PO", "PETER", "J.", "DANIELS", "CC:", "RJWELTER-", "-", "PW17", "PO", "RICHARD", "J.", "WELTER", "LTWELCH", "--RCC1", "LAWRENCE", "T", "WELCH",...

[ [ 54, 44, 102, 55 ], [ 111, 44, 138, 54 ], [ 202, 44, 239, 54 ], [ 464, 44, 503, 55 ], [ 512, 44, 541, 55 ], [ 551, 43, 587, 55 ], [ 625, 42, 701, 54 ], [ 710, 42, ...

what is the date mentioned in the forwarding note ?

10/26/93

527

[ "From:", "PLK", "RCC1", "Date", "and", "time", "10/27/93", "09", ":", "36:07", "To:", "PJDANIEL-", "-", "PW17", "PO", "PETER", "J.", "DANIELS", "CC:", "RJWELTER-", "-", "PW17", "PO", "RICHARD", "J.", "WELTER", "LTWELCH", "--RCC1", "LAWRENCE", "T", "WELCH",...

[ [ 54, 44, 102, 55 ], [ 111, 44, 138, 54 ], [ 202, 44, 239, 54 ], [ 464, 44, 503, 55 ], [ 512, 44, 541, 55 ], [ 551, 43, 587, 55 ], [ 625, 42, 701, 54 ], [ 710, 42, ...

what is the time mentioned in the forwarding note ?

15:44

527

[ "From:", "PLK", "RCC1", "Date", "and", "time", "10/27/93", "09", ":", "36:07", "To:", "PJDANIEL-", "-", "PW17", "PO", "PETER", "J.", "DANIELS", "CC:", "RJWELTER-", "-", "PW17", "PO", "RICHARD", "J.", "WELTER", "LTWELCH", "--RCC1", "LAWRENCE", "T", "WELCH",...

[ [ 54, 44, 102, 55 ], [ 111, 44, 138, 54 ], [ 202, 44, 239, 54 ], [ 464, 44, 503, 55 ], [ 512, 44, 541, 55 ], [ 551, 43, 587, 55 ], [ 625, 42, 701, 54 ], [ 710, 42, ...

To whom this email was forwaded?

RUPPEL, PATRICIA

530

[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "41", "003/006", "contact,", "what", "can", "we", "do?", "(7)", "As", "we", "point", "out", "in", "our", "action", "plan", ...

[ [ 60, 12, 153, 21 ], [ 182, 11, 227, 21 ], [ 272, 12, 290, 21 ], [ 300, 11, 338, 21 ], [ 347, 11, 383, 21 ], [ 42, 21, 79, 32 ], [ 88, 21, 135, 32 ], [ 144, 22, 191...

what is the fax mentioned ?

06 6204 2244

530

[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "41", "003/006", "contact,", "what", "can", "we", "do?", "(7)", "As", "we", "point", "out", "in", "our", "action", "plan", ...

[ [ 60, 12, 153, 21 ], [ 182, 11, 227, 21 ], [ 272, 12, 290, 21 ], [ 300, 11, 338, 21 ], [ 347, 11, 383, 21 ], [ 42, 21, 79, 32 ], [ 88, 21, 135, 32 ], [ 144, 22, 191...

what is year date and time mentioned?

2002 08/08 21:49

530

[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "41", "003/006", "contact,", "what", "can", "we", "do?", "(7)", "As", "we", "point", "out", "in", "our", "action", "plan", ...

[ [ 60, 12, 153, 21 ], [ 182, 11, 227, 21 ], [ 272, 12, 290, 21 ], [ 300, 11, 338, 21 ], [ 347, 11, 383, 21 ], [ 42, 21, 79, 32 ], [ 88, 21, 135, 32 ], [ 144, 22, 191...

what is the name of the division ?

TAKEDA DEVELOP DIVISION

530

[ "08/07/2002", "18:46", "06", "6204", "2244", "2002", "08/08", "21:49", "FAX", "06", "6204", "2244", "TAKEDA", "DEVELOP", "DIVISION", "41", "003/006", "contact,", "what", "can", "we", "do?", "(7)", "As", "we", "point", "out", "in", "our", "action", "plan", ...

[ [ 60, 12, 153, 21 ], [ 182, 11, 227, 21 ], [ 272, 12, 290, 21 ], [ 300, 11, 338, 21 ], [ 347, 11, 383, 21 ], [ 42, 21, 79, 32 ], [ 88, 21, 135, 32 ], [ 144, 22, 191...

to whom they can ask directly to disclose the details of "promotion study"?

FDA

531

[ "8", "January", "2003", "To:", "MPDRAP", "I", "Leader", "cc:", "CEOs", "and", "General", "Managers", "of", "Pharmaceutical", "Units", "My", "Concerns", "about", "sNDA", "for", "Actos", "45mg", "in", "the", "USA", "(Reconfirmation)", "Pharmaceutical", "Internatio...

[ [ 653, 128, 662, 139 ], [ 665, 128, 715, 140 ], [ 717, 128, 748, 140 ], [ 200, 146, 222, 158 ], [ 224, 146, 288, 159 ], [ 291, 147, 298, 159 ], [ 300, 146, 345, 159 ], [ 20...

what is the date mentioned in the letter

8 January 2003

531

[ "8", "January", "2003", "To:", "MPDRAP", "I", "Leader", "cc:", "CEOs", "and", "General", "Managers", "of", "Pharmaceutical", "Units", "My", "Concerns", "about", "sNDA", "for", "Actos", "45mg", "in", "the", "USA", "(Reconfirmation)", "Pharmaceutical", "Internatio...

[ [ 653, 128, 662, 139 ], [ 665, 128, 715, 140 ], [ 717, 128, 748, 140 ], [ 200, 146, 222, 158 ], [ 224, 146, 288, 159 ], [ 291, 147, 298, 159 ], [ 300, 146, 345, 159 ], [ 20...

To whom this letter is addressed?

MPDRAP I Leader

531

[ "8", "January", "2003", "To:", "MPDRAP", "I", "Leader", "cc:", "CEOs", "and", "General", "Managers", "of", "Pharmaceutical", "Units", "My", "Concerns", "about", "sNDA", "for", "Actos", "45mg", "in", "the", "USA", "(Reconfirmation)", "Pharmaceutical", "Internatio...

[ [ 653, 128, 662, 139 ], [ 665, 128, 715, 140 ], [ 717, 128, 748, 140 ], [ 200, 146, 222, 158 ], [ 224, 146, 288, 159 ], [ 291, 147, 298, 159 ], [ 300, 146, 345, 159 ], [ 20...

what is mentioned in the CC?

CEOs and General Managers of Pharmaceutical Units

531

[ "8", "January", "2003", "To:", "MPDRAP", "I", "Leader", "cc:", "CEOs", "and", "General", "Managers", "of", "Pharmaceutical", "Units", "My", "Concerns", "about", "sNDA", "for", "Actos", "45mg", "in", "the", "USA", "(Reconfirmation)", "Pharmaceutical", "Internatio...

[ [ 653, 128, 662, 139 ], [ 665, 128, 715, 140 ], [ 717, 128, 748, 140 ], [ 200, 146, 222, 158 ], [ 224, 146, 288, 159 ], [ 291, 147, 298, 159 ], [ 300, 146, 345, 159 ], [ 20...

combination therapy in the us market accounts for how much % of total actos sales .

64

535

[ "Task", "Notes", "Lead", "Responsibility", "Due", "Date", "4.", "PEDIATRIC", "STUDIES", "(CONTINUED)", "Evaluate", "data", "from", "Actos", "507", ">", "Evaluate", "data", "to", "support", "Amy", "Hagaman", "August", "5", "ustification", "to", "proceed", "with",...

[ [ 174, 101, 207, 115 ], [ 385, 101, 437, 115 ], [ 534, 101, 576, 116 ], [ 580, 101, 705, 117 ], [ 768, 102, 805, 116 ], [ 808, 103, 850, 116 ], [ 90, 122, 104, 135 ], [ 107...

What is the due date to evaluate data from actos 507?

August 5

535

[ "Task", "Notes", "Lead", "Responsibility", "Due", "Date", "4.", "PEDIATRIC", "STUDIES", "(CONTINUED)", "Evaluate", "data", "from", "Actos", "507", ">", "Evaluate", "data", "to", "support", "Amy", "Hagaman", "August", "5", "ustification", "to", "proceed", "with",...

[ [ 174, 101, 207, 115 ], [ 385, 101, 437, 115 ], [ 534, 101, 576, 116 ], [ 580, 101, 705, 117 ], [ 768, 102, 805, 116 ], [ 808, 103, 850, 116 ], [ 90, 122, 104, 135 ], [ 107...

who is the lead responsibility for developing additional monitoring plan for actos 508

Amy Hagaman

535

[ "Task", "Notes", "Lead", "Responsibility", "Due", "Date", "4.", "PEDIATRIC", "STUDIES", "(CONTINUED)", "Evaluate", "data", "from", "Actos", "507", ">", "Evaluate", "data", "to", "support", "Amy", "Hagaman", "August", "5", "ustification", "to", "proceed", "with",...

[ [ 174, 101, 207, 115 ], [ 385, 101, 437, 115 ], [ 534, 101, 576, 116 ], [ 580, 101, 705, 117 ], [ 768, 102, 805, 116 ], [ 808, 103, 850, 116 ], [ 90, 122, 104, 135 ], [ 107...

what is the due date for "draft justification for actos 508" ?

August 12

535

[ "Task", "Notes", "Lead", "Responsibility", "Due", "Date", "4.", "PEDIATRIC", "STUDIES", "(CONTINUED)", "Evaluate", "data", "from", "Actos", "507", ">", "Evaluate", "data", "to", "support", "Amy", "Hagaman", "August", "5", "ustification", "to", "proceed", "with",...

[ [ 174, 101, 207, 115 ], [ 385, 101, 437, 115 ], [ 534, 101, 576, 116 ], [ 580, 101, 705, 117 ], [ 768, 102, 805, 116 ], [ 808, 103, 850, 116 ], [ 90, 122, 104, 135 ], [ 107...

when was this last updated ?

August 1, 2002

535

[ "Task", "Notes", "Lead", "Responsibility", "Due", "Date", "4.", "PEDIATRIC", "STUDIES", "(CONTINUED)", "Evaluate", "data", "from", "Actos", "507", ">", "Evaluate", "data", "to", "support", "Amy", "Hagaman", "August", "5", "ustification", "to", "proceed", "with",...

[ [ 174, 101, 207, 115 ], [ 385, 101, 437, 115 ], [ 534, 101, 576, 116 ], [ 580, 101, 705, 117 ], [ 768, 102, 805, 116 ], [ 808, 103, 850, 116 ], [ 90, 122, 104, 135 ], [ 107...

Who is the lead responsible person for draft justification for actos 508?

Amy Hagaman/Alfonso Perez

543

[ "Ms.", "Wakamatsu,", "Assistant", "manager,", "Dept.", "Strategic", "Development,", "et", "al.", "Attachment:", "NDA", "schedule", "for", "each", "project", "approved", "on", "the", "5th", "GDC", "1.", "Openings", "Remarks", "Dr.", "Kitazawa", "made", "opening", ...

[ [ 107, 142, 132, 152 ], [ 134, 142, 218, 152 ], [ 220, 142, 280, 153 ], [ 282, 142, 346, 153 ], [ 348, 142, 385, 153 ], [ 387, 142, 446, 153 ], [ 448, 141, 540, 153 ], [ 54...

Which is the core organization of Takeda pharmaceutical Company?

Pharmaceutical development Division

543

[ "Ms.", "Wakamatsu,", "Assistant", "manager,", "Dept.", "Strategic", "Development,", "et", "al.", "Attachment:", "NDA", "schedule", "for", "each", "project", "approved", "on", "the", "5th", "GDC", "1.", "Openings", "Remarks", "Dr.", "Kitazawa", "made", "opening", ...

[ [ 107, 142, 132, 152 ], [ 134, 142, 218, 152 ], [ 220, 142, 280, 153 ], [ 282, 142, 346, 153 ], [ 348, 142, 385, 153 ], [ 387, 142, 446, 153 ], [ 448, 141, 540, 153 ], [ 54...

Who made the opening remarks ?

Dr. Kitazawa

543

[ "Ms.", "Wakamatsu,", "Assistant", "manager,", "Dept.", "Strategic", "Development,", "et", "al.", "Attachment:", "NDA", "schedule", "for", "each", "project", "approved", "on", "the", "5th", "GDC", "1.", "Openings", "Remarks", "Dr.", "Kitazawa", "made", "opening", ...

[ [ 107, 142, 132, 152 ], [ 134, 142, 218, 152 ], [ 220, 142, 280, 153 ], [ 282, 142, 346, 153 ], [ 348, 142, 385, 153 ], [ 387, 142, 446, 153 ], [ 448, 141, 540, 153 ], [ 54...

When is the clinical expert meeting scheduled?

for October 1 and 2.

539

[ "Actos", "Pediatric", "Working", "Group", "Date:", "20", "April", "2006", "Time:", "4:00pm", "-", "5:00pm", "Meeting", "Minutes", "Place:", "Meeting", "Room", "403", "Attendees", "Attendees", "Alfonso", "Perez", "-", "Clinical", "Karen", "Kaluzny", "-", "Project...

[ [ 57, 76, 111, 92 ], [ 114, 77, 197, 92 ], [ 200, 76, 279, 93 ], [ 282, 76, 341, 93 ], [ 410, 76, 460, 91 ], [ 462, 77, 487, 91 ], [ 489, 77, 537, 91 ], [ 539, 76, ...

what is the date mentioned in the given information ?

20 April 2006

539

[ "Actos", "Pediatric", "Working", "Group", "Date:", "20", "April", "2006", "Time:", "4:00pm", "-", "5:00pm", "Meeting", "Minutes", "Place:", "Meeting", "Room", "403", "Attendees", "Attendees", "Alfonso", "Perez", "-", "Clinical", "Karen", "Kaluzny", "-", "Project...

[ [ 57, 76, 111, 92 ], [ 114, 77, 197, 92 ], [ 200, 76, 279, 93 ], [ 282, 76, 341, 93 ], [ 410, 76, 460, 91 ], [ 462, 77, 487, 91 ], [ 489, 77, 537, 91 ], [ 539, 76, ...

What is the meeting time mentioned here?

4:00pm - 5:00pm