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The study objectives were to evaluate the safety , tolerability , and preliminary efficacy of multiple doses of dulanermin in combination with modified FOLFOX6 and bevacizumab in previously untreated patients with locally advanced , recurrent , or metastatic colorectal cancer . | [{'class': 'POS', 'spans': ['dulanermin', 'FOLFOX6', 'bevacizumab'], 'is_context_needed': True}] |
Inhalatory beta2-mimetics with long-term action ( LABA ) , formoterol and salmeterol , possess a period of action longer than 12 hours . | [] |
This study evaluates the possible protective effects of the calcium channel blocker amlodipine , the angiotensin converting enzyme inhibitor lisinopril , and the xanthine oxidase inhibitor allopurinol against experimental acetaminophen-induced hepatotoxicity , aiming to understand its underlying hepatotoxic mechanisms ... | [] |
The study was conducted in 90 patients operated on for unilateral breast cancer who were then assigned to receive either 12 intravenous cycles of cyclophosphamide , methotrexate and fluorouracil ( CMF ) every three weeks , or no further treatment . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'methotrexate', 'fluorouracil'], 'is_context_needed': True}] |
This study compared the efficacy of topical emedastine 0.05 % ophthalmic solution with that of oral loratadine 10 mg and their combination in the conjunctival allergen challenge model of allergic conjunctivitis . | [{'class': 'POS', 'spans': ['emedastine', 'loratadine'], 'is_context_needed': True}] |
Erythromycin , clindamycin and carbenicillin suppressed the donor flora permanently , as could be seen by the reduced colonization resistance . | [] |
Mycophenolate mofetil resulted in rapid improvement of steroid-refractory immune-related adverse event hepatitis , induced by nivolumab plus ipilimumab . | [{'class': 'COMB', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}] |
The mannose-linked prodrugs of saquinavir and indinavir display therefore a most promising therapeutic potential provided that bioavailability , penetration into the HIV infected macrophages , and HIV-reservoirs of these PIs are improved . | [] |
Resistant isolates emerged quickly and uniformly in all patients administered nevirapine either as monotherapy or in combination with zidovudine ( AZT ) . | [{'class': 'COMB', 'spans': ['nevirapine', 'zidovudine'], 'is_context_needed': True}] |
Postoperative combination chemotherapy for six cycles with cisplatin ( 100 mg/m2 per day for 1 day every 3 weeks ) , bleomycin ( 15 units intravenously weekly for 18 weeks ) and etoposide ( 100 mg/m2 per day for 3 days every 3 weeks ) were given and the tumor responded dramatically . | [{'class': 'POS', 'spans': ['cisplatin', 'bleomycin', 'etoposide'], 'is_context_needed': False}] |
The other received chemotherapy including prednisone , vincristine , cytarabine and L-asparaginase , combined with intrathecal injections of methotrexate , dexamethasone and Ara-C and supporting treatment . | [{'class': 'POS', 'spans': ['prednisone', 'vincristine', 'cytarabine', 'L-asparaginase'], 'is_context_needed': True}] |
Then , neoadjuvant chemotherapy ( NAC ) consisting of a combination of 5-fluorouracil ( 5-FU ) , oxaliplatin , irinotecan , and leucovorin ( FOLFOXIRI ) was planned , followed by primary tumor resection . | [{'class': 'POS', 'spans': ['5-fluorouracil', 'oxaliplatin', 'irinotecan', 'leucovorin'], 'is_context_needed': True}] |
Interestingly , aspirin not only significantly inhibited the growth of TNBC cells , but also attenuated YAP and β-catenin expression by upregulating the E3 ubiquitin ligase β-TrCP to abolished docetaxel and vinorelbine resistance . | [{'class': 'POS', 'spans': ['aspirin', 'docetaxel', 'vinorelbine'], 'is_context_needed': False}] |
No alterations in paclitaxel or doxorubicin pharmacokinetics were observed when the drugs were administered alone versus in combination . | [{'class': 'COMB', 'spans': ['paclitaxel', 'doxorubicin'], 'is_context_needed': True}] |
Twenty-seven received rituximab mainly in addition to high-dose cytarabine and etoposide ( n = 18 ) and/or ifosfamide , carboplatin , and etoposide ( n = 7 ) . | [{'class': 'COMB', 'spans': ['rituximab', 'cytarabine', 'etoposide', 'ifosfamide', 'carboplatin', 'etoposide'], 'is_context_needed': True}] |
A significant reduction in plasma 8-isoprostane and oxLDL levels was observed in all treatment groups [ by 10 % , 8 % and 6 % ( p < 0.05 compared with baseline ) and 41 % , 40 % and 39 % ( p < 0.001 compared with baseline ) in simvastatin , simvastatin/ezetimibe and rosuvastatin groups , respectively ] . | [] |
Both mono and combination therapies achieved the primary efficacy parameters : lowered diastolic blood pressure ( at trough ) more than placebo , p < 01 ( except the 120 mg verapamil SR , NS , 0.5 mg trandolapril , 0.5/180 and 2/120 combinations , p < 05 ) , yielded a trough to peak ratio of > 0.52 and had higher perce... | [{'class': 'POS', 'spans': ['verapamil', 'trandolapril'], 'is_context_needed': False}] |
In metastastic patients , the combination of gemcitabine and cisplatin has become the new standard regimen due to a lower toxicity in comparison to the combination of methotrexate , vinblastine , doxorubicin , and cisplatin ( MVAC ) . | [{'class': 'POS', 'spans': ['gemcitabine', 'cisplatin'], 'is_context_needed': False}, {'class': 'COMB', 'spans': [1, 2, 3], 'is_context_needed': True}] |
In the last few years , a flurry of new and more potent ALK inhibitors has emerged for the treatment of ALK-positive NSCLC , including ceritinib ( LDK378 ) , alectinib ( RO5424802/CH5424802 ) , AP26113 , ASP3026 , TSR-011 , PF-06463922 , RXDX-101 , X-396 , and CEP-37440 . | [] |
A randomized clinical trial of adjuvant chemotherapy with doxorubicin , ifosfamide , and cisplatin followed by radiotherapy versus radiotherapy alone in patients with localized uterine sarcomas ( SARCGYN study ) . | [{'class': 'POS', 'spans': ['doxorubicin', 'ifosfamide', 'cisplatin'], 'is_context_needed': True}] |
Combination therapy with irinotecan ( CPT-11 ) , 5-fluorouracil ( 5-FU ) and leucovorin is widely used for the treatment of metastatic colorectal cancer . | [{'class': 'POS', 'spans': ['irinotecan', 'leucovorin', '5-fluorouracil'], 'is_context_needed': True}] |
Long-term safety and outcome of fludarabine , cyclophosphamide and mitoxantrone ( FCM ) regimen in previously untreated patients with advanced follicular lymphoma : 12 years follow-up of a phase 2 trial . | [{'class': 'POS', 'spans': ['fludarabine', 'cyclophosphamide', 'mitoxantrone'], 'is_context_needed': True}] |
After clinical improvement under vemurafenib monotherapy , four cycles of ipilimumab were additionally administered . | [{'class': 'POS', 'spans': ['vemurafenib', 'ipilimumab'], 'is_context_needed': True}] |
Bevacizumab plus paclitaxel versus bevacizumab plus capecitabine as first-line treatment for HER2-negative metastatic breast cancer ( TURANDOT ): primary endpoint results of a randomised , open-label , non-inferiority , phase 3 trial . | [{'class': 'POS', 'spans': ['bevacizumab', 'capecitabine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}] |
She underwent rectectomy and adjuvant chemotherapy with fluorouracil , leucovorin plus oxaliplatin for stage IIIB rectal cancer . | [{'class': 'COMB', 'spans': ['fluorouracil', 'leucovorin', 'oxaliplatin'], 'is_context_needed': True}] |
We designed this phase II trial to evaluate the safety , tolerability , and efficacy of the combination of carboplatin , paclitaxel , cetuximab , and bevacizumab in chemotherapy-naive patients with advanced , nonsquamous NSCLC . | [{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel', 'cetuximab', 'bevacizumab'], 'is_context_needed': True}] |
All patients underwent mexiletine monotherapy ( M-mono ) , propafenone monotherapy ( P-mono ) , low dose combination therapy ( low M+P ) , and full dose combination therapy ( full M+P ) . | [{'class': 'POS', 'spans': ['mexiletine', 'propafenone'], 'is_context_needed': True}] |
Cephalexin , 500 mg 4 times daily , plus trimethoprim-sulfamethoxazole , 320 mg/1600 mg twice daily , for 7 days ( n = 248 participants ) or cephalexin plus placebo for 7 days ( n = 248 participants ) . | [{'class': 'COMB', 'spans': ['Cephalexin', 'trimethoprim-sulfamethoxazole'], 'is_context_needed': True}] |
In the NALA trial , neratinib plus capecitabine led to increased PFS and time to intervention for central nervous system disease over the standard regimen of lapatinib plus capecitabine . | [{'class': 'POS', 'spans': ['neratinib', 'capecitabine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}] |
Since the patient had anemia , aspirin and cilostazol were discontinued after diagnosis . | [{'class': 'NEG', 'spans': ['aspirin', 'cilostazol'], 'is_context_needed': True}] |
This case report describes a patient with O-NHL which was possibly linked to the combination of methotrexate and etanercept for the treatment of her rheumatoid arthritis . | [{'class': 'NEG', 'spans': ['methotrexate', 'etanercept'], 'is_context_needed': False}] |
In a prospective , pragmatic , randomised , parallel group study , 170 patients of mean ( SD ) age 37 ( 12 ) years with acute asthma ( peak expiratory flow ( PEF ) 212 ( 80 ) l/min ) presenting to hospital received treatment with either high dose prednisolone and continuous nebulised salbutamol as recommended in the US... | [{'class': 'POS', 'spans': ['prednisolone', 'salbutamol'], 'is_context_needed': True}] |
We report a case of a 78-year-old white male ( weight , 90 kg ) presented to the Department of Medical Oncology and Hematology , Istituto Clinico Humanitas , Rozzano , Milan , Italy , with refractory MM immunoglobulin G kappa ( IgGkappa ) , Durie-Salmon Stage IIA , with progressive renal failure after an oral melphalan... | [{'class': 'NEG', 'spans': ['melphalan', 'prednisone', 'thalidomide'], 'is_context_needed': False}] |
Following an intravitreal injection of ranibizumab , off-label administration of intravitreal dexamethasone was considered to reduce the edema . | [{'class': 'POS', 'spans': ['ranibizumab', 'dexamethasone'], 'is_context_needed': False}] |
Rabeprazole was similar to omeprazole and superior to placebo in both maintenance of healing and prevention of symptoms in patients with healed GERD in 1-year studies . | [] |
We performed a prospective , preplanned , pooled analysis of six randomized , phase 3 trials that were conducted concurrently to evaluate the noninferiority of adjuvant therapy with either FOLFOX ( fluorouracil , leucovorin , and oxaliplatin ) or CAPOX ( capecitabine and oxaliplatin ) administered for 3 months , as com... | [{'class': 'POS', 'spans': ['capecitabine', 'oxaliplatin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2], 'is_context_needed': True}] |
Growth inhibition and apoptosis were significantly ( P < 0.05 ) higher in BxPC-3 , HPAC , and PANC-1 cells treated with celecoxib and erlotinib than cells treated with either celecoxib or erlotinib . | [{'class': 'POS', 'spans': ['celecoxib', 'erlotinib'], 'is_context_needed': False}] |
Subcutaneous aspirin , 100 mg/kg , which reduced duodenal PGE2 generation to a greater degree than either ulcerogen , given in conjunction with pentagastrin , did not produce visible duodenal ulceration.(ABSTRACT TRUNCATED AT 250 WORDS ) | [] |
Prevalence of metronidazole , clarithromycin , and amoxicillin resistance is high in developing world including Africa . | [] |
These results indicate that low-dose 100 microg levonorgestrel and 20 microg ethinyl estradiol given for 21 days is effective in suppressing ovarian activity and they confirm the contraceptive efficacy observed in clinical trials ( Pearl index of 0.8 ) . | [{'class': 'POS', 'spans': ['levonorgestrel', 'ethinyl'], 'is_context_needed': False}] |
The combination of ixabepilone and capecitabine in the phase II study resulted in an ORR of 23 % in triple-negative patients . | [{'class': 'POS', 'spans': ['ixabepilone', 'capecitabine'], 'is_context_needed': True}] |
We report the rare case of a 27-year-old premenopausal woman with locally advanced breast cancer that was marked by rapid tumor necrosis followed by massive hemorrhage shortly after bevacizumab and paclitaxel administration . | [{'class': 'NEG', 'spans': ['bevacizumab', 'paclitaxel'], 'is_context_needed': False}] |
More recently , paclitaxel plus carboplatin also has been evaluated in previously untreated patients . | [{'class': 'COMB', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
Mitoxantrone and cyclophosphamide in advanced breast cancer : a pilot study . | [{'class': 'POS', 'spans': ['Mitoxantrone', 'cyclophosphamide'], 'is_context_needed': True}] |
We retrospectively analyzed the data of 37 patients who had postprandial hyperglycemia ( ≥10.0 mmol/L ) with BOT ( long-acting insulin plus glimepiride ) with their insulin titrated enough to keep preprandial glycemia < 7.2 mmol/L , and who had their treatment changed to liraglutide monotherapy , with the subsequent ad... | [{'class': 'COMB', 'spans': ['liraglutide', 'glimepiride'], 'is_context_needed': True}] |
It was shown that the H2 receptor antagonist cimetidine when combined with N , N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl ( DPPE ) , a tamoxifen derivate , inhibits the proliferation of HT168 cells . | [{'class': 'POS', 'spans': ['cimetidine', 'DPPE', 'N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl'], 'is_context_needed': False}] |
We report here on a case of successful treatment of a patient suffering with severe liver dysfunction and metastatic gastric cancer ; the patient was treated with a combination of capecitabine and oxaliplatin ( XELOX ) . | [{'class': 'POS', 'spans': ['capecitabine', 'oxaliplatin'], 'is_context_needed': False}] |
From 1987 to 1991 , 194 previously untreated patients received vincristine and ifosfamide plus dactinomycin or etoposide for 1 - 2 years . | [{'class': 'NEG', 'spans': ['vincristine', 'ifosfamide', 'dactinomycin'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 1, 3], 'is_context_needed': True}] |
This nested substudy of the AVALON trial assessed the effects of coadministered amlodipine and atorvastatin vs. either therapy alone or placebo on arterial compliance , to evaluate the vascular benefits of coadministered therapy . | [{'class': 'POS', 'spans': ['amlodipine', 'atorvastatin'], 'is_context_needed': True}] |
We analysed the serial dermatoscopic photographs of atypical melanocytic lesions taken from patients with advanced metastatic melanoma on four different systemic therapies ( selective BRAF-inhibitor monotherapy , dabrafenib combined with trametinib [ D&T ] , anti-programmed cell death protein 1 [ anti-PD1 ] therapies ,... | [{'class': 'COMB', 'spans': ['dabrafenib', 'trametinib'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}] |
He received six cycles MOPP-induction therapy followed by a chlorambucil maintenance therapy with procarbazine and prednisone reinforcements . | [{'class': 'NEG', 'spans': ['chlorambucil', 'procarbazine', 'prednisone'], 'is_context_needed': True}] |
The introduction of rituximab , alemtuzumab , and bendamustine has improved the current outlook for patients with CLL . | [] |
Ten patients were treated with pirfenidone ( 2403 mg/die ) and 1 with nintedanib | [] |
More recently , case-control and cohort studies and well-conceived , phase II/III clinical trials have been done or are under way to evaluate putative chemopreventive agents including established drugs like aspirin and non-steroidal anti-inflammatory drugs ( NSAIDs ) , 5-aminosalicylates and statins ; more controversia... | [] |
Frontline bortezomib and rituximab for the treatment of newly diagnosed high tumour burden indolent non-Hodgkin lymphoma : a multicentre phase II study . | [{'class': 'POS', 'spans': ['bortezomib', 'rituximab'], 'is_context_needed': True}] |
The ifosfamide , carboplatin and etoposide ( ICE ) regimen was developed to address these challenges . | [{'class': 'POS', 'spans': ['ifosfamide', 'carboplatin', 'etoposide'], 'is_context_needed': True}] |
Tofacitinib combination therapy was also associated with the lower PMPM cost compared with adalimumab combination therapy in the TNF-IR analysis . | [] |
Effect of sequential treatments with alendronate , parathyroid hormone ( 1 - 34 ) and raloxifene on cortical bone mass and strength in ovariectomized rats . | [{'class': 'POS', 'spans': ['alendronate', 'parathyroid hormone', 'raloxifene'], 'is_context_needed': True}] |
Atorvastatin and metformin both have pleiotropic effects . | [{'class': 'POS', 'spans': ['Atorvastatin', 'metformin'], 'is_context_needed': True}] |
Bevacizumab , a monoclonal antibody targeting vascular endothelial growth factor , is the first antiangiogenic drug to show improved efficacy when used in combination with irinotecan and oxaliplatin for first- and second-line treatment of CRC . | [{'class': 'POS', 'spans': ['Bevacizumab', 'irinotecan', 'oxaliplatin'], 'is_context_needed': False}] |
Available data indicate that GLY and aclidinium have similar efficacy to tiotropium in terms of improving lung function , dyspnea , exacerbations , and health status . | [] |
Between Oct 24 , 2016 , and Jan 24 , 2018 , 861 patients were randomly assigned to receive pembrolizumab plus axitinib ( n=432 ) or sunitinib monotherapy ( n=429 ) . | [{'class': 'POS', 'spans': ['pembrolizumab', 'axitinib'], 'is_context_needed': True}] |
Patients received 175 mg/m of paclitaxel over a 3 h infusion , followed by nedaplatin 80 mg/m in a 1 h infusion on day 1 every 3 weeks for up to 6 treatment cycles . | [{'class': 'POS', 'spans': ['paclitaxel', 'nedaplatin'], 'is_context_needed': True}] |
After a median follow-up of 9.5 years , 10-year OS rates in the bolus/infusional fluorouracil plus leucovorin ( LV5FU2 ) and LV5FU2 plus oxaliplatin ( FOLFOX4 ) arms were 67.1 % versus 71.7 % ( hazard ratio [ HR ] , 0.85 ; P = .043 ) in the whole population , 79.5 % versus 78.4 % for stage II ( HR , 1.00 ; P = .980 ) ,... | [{'class': 'POS', 'spans': ['fluorouracil', 'leucovorin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
[ Effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs ] . | [{'class': 'POS', 'spans': ['dofetilide', 'verapamil'], 'is_context_needed': True}] |
Patients with pancreatic adenocarcinoma , pre-treated with gemcitabine-based chemotherapy , were treated with capecitabine ( 800 mg/m(2 ) orally , twice a day for 14 days ) and docetaxel ( 75 mg/m(2 ) i.v , on day 1 ) , every 3 weeks . | [{'class': 'POS', 'spans': ['capecitabine', 'docetaxel'], 'is_context_needed': True}] |
Comparative study of dose escalation versus interval reduction to obtain dose-intensification of epirubicin and cyclophosphamide with granulocyte colony-stimulating factor in advanced breast cancer . | [{'class': 'POS', 'spans': ['epirubicin', 'cyclophosphamide'], 'is_context_needed': True}] |
The hearts were treated during the whole procedure either with vehicle , 0.5 μM flecainide ( sodium channel blocker ) or 100 μM streptomycin ( here used as stretch-activated ion-channel blocker ) . | [{'class': 'COMB', 'spans': ['flecainide', 'streptomycin'], 'is_context_needed': True}] |
In the APHINITY study ( NCT01358877 , BIG 4 - 11/BO25126/TOC4939 G ) , pertuzumab added to trastuzumab and chemotherapy significantly improved invasive disease-free survival as adjuvant treatment for patients with HER2-positive early breast cancer . | [{'class': 'POS', 'spans': ['pertuzumab', 'trastuzumab'], 'is_context_needed': False}] |
In two trials , an anti-EGFR antibody ( panitumumab or cetuximab ) reduced median survival when added to bevacizumab in previously untreated patients . | [{'class': 'NEG', 'spans': ['panitumumab', 'bevacizumab'], 'is_context_needed': False}, {'class': 'NEG', 'spans': [1, 2], 'is_context_needed': False}] |
The results of the APPEARANCE trial indicate that adapalene does not prevent acne-like rash over placebo when added to topical moisturizer and oral minocycline but instead may have a detrimental effect . | [{'class': 'NEG', 'spans': ['adapalene', 'minocycline'], 'is_context_needed': False}] |
Both regimens included cyclophosphamide , methotrexate , 5-FU , prednisone , and doxorubicin . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}] |
In 2011 , new drugs were approved by the U.S. Food and Drug Administration , including peginterferon alfa-2b for patients with stage III disease , vemurafenib for patients with metastatic melanoma with the BRAF V600E mutation , and ipilimumab , a monoclonal antibody directed to the CTLA-4 T lymphocyte receptor , to com... | [] |
Individual studies have reported differences between antiandrogens in terms of both tolerability and efficacy-for example , bicalutamide has been shown to be better tolerated than flutamide , and may be associated with improved survival . | [] |
A Randomized , Multicenter , Double-blind , Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis . | [{'class': 'POS', 'spans': ['Montelukast', 'Levocetirizine'], 'is_context_needed': True}] |
Intravenous administration of cefoperazone and sulbactam given as individual agents compared with the combination did not show pharmacokinetic differences that are likely to produce clinically relevant effects . | [{'class': 'COMB', 'spans': ['cefoperazone', 'sulbactam'], 'is_context_needed': True}] |
HDC with cyclophosphamide , carmustine and thiotepa was given from day -7 to -5 . | [{'class': 'COMB', 'spans': ['cyclophosphamide', 'carmustine', 'thiotepa'], 'is_context_needed': True}] |
Melatonin or sulpiride could replace these environmental factors . | [] |
Trastuzumab and Pertuzumab Plant Biosimilars : Modification of Asn297-linked Glycan of the mAbs Produced in a Plant with Fucosyltransferase and Xylosyltransferase Gene Knockouts . | [] |
A recently reported phase II trial has demonstrated that trastuzumab plus vinorelbine is both effective ( overall response rate 75 % ) and well tolerated , with the major side effects being typical of single-agent vinorelbine . | [{'class': 'POS', 'spans': ['trastuzumab', 'vinorelbine'], 'is_context_needed': False}] |
Men with prostate cancer were randomly assigned to one of four treatment arms : leuprorelin , goserelin , cyproterone acetate ( CPA ) , or close clinical monitoring . | [] |
There were no significant differences between the two treatment groups , except that amantadine was inferior to mycophenolate mofetil regarding the outcome failure to achieve end-of treatment virological response ( low quality of evidence ) . | [] |
Furthermore , more incidences of severe fatigue , thrombocytopenia , and neutropenia were recorded for sunitinib , but pazopanib had more liver toxicity . | [] |
Streptomycin appears to be the most effective agent followed by gentamicin and the least active was netilmicin . | [] |
Neither behavioral therapy , clomipramine , methylphenidate , buspirone , nor naltrexone was effective in monotherapeutic trials . | [] |
Pharmacokinetic PET imaging data analysis quantitatively showed the pharmacological effects of teriparatide-induced suppression of upper gastrointestinal motility and its restoration by granisetron and mosapride . | [] |
Differences were observed when palbociclib or ribociclib was used in combination with letrozole or anastrozole or fulvestrant . | [{'class': 'COMB', 'spans': ['palbociclib', 'letrozole'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 3], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 4], 'is_context_needed': True}] |
Resolution of muscle damage followed discontinuation of cyclosporine and lovastatin therapy . | [{'class': 'NEG', 'spans': ['cyclosporine', 'lovastatin'], 'is_context_needed': False}] |
In order to elucidate the possible interference of the antiparkinson drug 1-aminoadamantane ( D-1 , PK Merz ) and the antispastic compound 1,3-dimethyl-5-aminoadamantane ( DMAA , D-145 , memantine , Memantine ) on neurotransmitter metabolism , the effect of D-1 and its C-alkyl derivatives memantine , 1-amino-3,5,7-trim... | [] |
Primary chemotherapy with gemcitabine , liposomal doxorubicin and docetaxel in patients with locally advanced breast cancer : results of a phase I trial . | [{'class': 'POS', 'spans': ['gemcitabine', 'doxorubicin', 'docetaxel'], 'is_context_needed': True}] |
A single bolus of dexamethasone , given before a single large meal , produces a delayed ( 6-hour ) but long-lasting increase in serum leptin ( over 16 hours ) . | [] |
The aim of this single-blind , randomized , controlled trial was to investigate treatment efficacy and safety of aripiprazole as an adjunct to valproic acid ( Ari+Val ) , compared with haloperidol plus valproic acid ( Hal+Val ) , in acute manic patients . | [{'class': 'POS', 'spans': ['aripiprazole', 'valproic'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
Because the incidence of nausea and vomiting is significantly reduced when ketorolac is used in place of opioids to attenuate postoperative pain , it would appear to be an appropriate choice of agent to use following propofol anesthesia . | [{'class': 'POS', 'spans': ['ketorolac', 'propofol'], 'is_context_needed': False}] |
The combination of vandetanib and bicalutamide was associated with considerable toxicity and did not have superior efficacy over bicalutamide alone . | [{'class': 'NEG', 'spans': ['vandetanib', 'bicalutamide'], 'is_context_needed': False}] |
Our data indicate that the addition of Aspirin or of Atenolol to Metformin might be beneficial for BC control , and that this activity is likely due to effects on both BC and microenvironment cells . | [{'class': 'POS', 'spans': ['Aspirin', 'Metformin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}] |
Coadministration of vorinostat and oxaliplatin induced G2/M phase arrest , triggered caspase-dependent apoptosis , and decreased tumorigenicity both in vitro and in vivo . | [{'class': 'POS', 'spans': ['vorinostat', 'oxaliplatin'], 'is_context_needed': False}] |
Randomized open trial of gentamicin and doxycycline for eradication of Bartonella quintana from blood in patients with chronic bacteremia . | [{'class': 'POS', 'spans': ['gentamicin', 'doxycycline'], 'is_context_needed': True}] |
The role of dual antiplatelet therapy combining aspirin and clopidogrel , is controversial . | [{'class': 'COMB', 'spans': ['aspirin', 'clopidogrel'], 'is_context_needed': True}] |
We conducted a dose-escalating study of daunorubicin combined to fixed doses of IM ( imatinib mesylate , 600 mg/d ) and cytarabine ( 200 mg/d for 7 days ) , followed by hematopoietic stem cell transplantation or maintenance therapy with single-agent IM in patients with MBC-CML at onset or after failure of therapy exclu... | [{'class': 'POS', 'spans': ['daunorubicin', 'imatinib', 'cytarabine'], 'is_context_needed': True}] |
[ Combination chemo-endocrine therapy of metastatic and stage IV breast cancer with cyclophosphamide , adriamycin , prednisolone and tamoxifen (CAPT)--with special reference to management of brain and liver metastasis ] . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'adriamycin', 'prednisolone', 'tamoxifen'], 'is_context_needed': True}] |
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