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When was the chemical make-up of penicillin discovered? | Context: Florey and Chain succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945. Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk. The chemical structure of penicillin was determined by Dorothy Crowfoot Hodgkin in 1945. Purified penicillin displayed potent antibacterial activity against a wide range of bacteria and had low toxicity in humans. Furthermore, its activity was not inhibited by biological constituents such as pus, unlike the synthetic sulfonamides. The discovery of such a powerful antibiotic was unprecedented, and the development of penicillin led to renewed interest in the search for antibiotic compounds with similar efficacy and safety. For their successful development of penicillin, which Fleming had accidentally discovered but could not develop himself, as a therapeutic drug, Ernst Chain and Howard Florey shared the 1945 Nobel Prize in Medicine with Fleming. Florey credited Dubos with pioneering the approach of deliberately and systematically searching for antibacterial compounds, which had led to the discovery of gramicidin and had revived Florey's research in penicillin.. Answer: {'text': ['1945'], 'answer_start': [356]}. Question: |
Who discovered the chemical structure of penicillin? | Context: Florey and Chain succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945. Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk. The chemical structure of penicillin was determined by Dorothy Crowfoot Hodgkin in 1945. Purified penicillin displayed potent antibacterial activity against a wide range of bacteria and had low toxicity in humans. Furthermore, its activity was not inhibited by biological constituents such as pus, unlike the synthetic sulfonamides. The discovery of such a powerful antibiotic was unprecedented, and the development of penicillin led to renewed interest in the search for antibiotic compounds with similar efficacy and safety. For their successful development of penicillin, which Fleming had accidentally discovered but could not develop himself, as a therapeutic drug, Ernst Chain and Howard Florey shared the 1945 Nobel Prize in Medicine with Fleming. Florey credited Dubos with pioneering the approach of deliberately and systematically searching for antibacterial compounds, which had led to the discovery of gramicidin and had revived Florey's research in penicillin.. Answer: {'text': ['Dorothy Crowfoot Hodgkin'], 'answer_start': [328]}. Question: |
When was the Nobel Prize first Purified? | Context: Florey and Chain succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945. Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk. The chemical structure of penicillin was determined by Dorothy Crowfoot Hodgkin in 1945. Purified penicillin displayed potent antibacterial activity against a wide range of bacteria and had low toxicity in humans. Furthermore, its activity was not inhibited by biological constituents such as pus, unlike the synthetic sulfonamides. The discovery of such a powerful antibiotic was unprecedented, and the development of penicillin led to renewed interest in the search for antibiotic compounds with similar efficacy and safety. For their successful development of penicillin, which Fleming had accidentally discovered but could not develop himself, as a therapeutic drug, Ernst Chain and Howard Florey shared the 1945 Nobel Prize in Medicine with Fleming. Florey credited Dubos with pioneering the approach of deliberately and systematically searching for antibacterial compounds, which had led to the discovery of gramicidin and had revived Florey's research in penicillin.. Answer: {'text': [], 'answer_start': []}. Question: |
When did penicillin G become available as a therapeudic drug? | Context: Florey and Chain succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945. Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk. The chemical structure of penicillin was determined by Dorothy Crowfoot Hodgkin in 1945. Purified penicillin displayed potent antibacterial activity against a wide range of bacteria and had low toxicity in humans. Furthermore, its activity was not inhibited by biological constituents such as pus, unlike the synthetic sulfonamides. The discovery of such a powerful antibiotic was unprecedented, and the development of penicillin led to renewed interest in the search for antibiotic compounds with similar efficacy and safety. For their successful development of penicillin, which Fleming had accidentally discovered but could not develop himself, as a therapeutic drug, Ernst Chain and Howard Florey shared the 1945 Nobel Prize in Medicine with Fleming. Florey credited Dubos with pioneering the approach of deliberately and systematically searching for antibacterial compounds, which had led to the discovery of gramicidin and had revived Florey's research in penicillin.. Answer: {'text': [], 'answer_start': []}. Question: |
Who came up with a way to quickly produce pus? | Context: Florey and Chain succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945. Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk. The chemical structure of penicillin was determined by Dorothy Crowfoot Hodgkin in 1945. Purified penicillin displayed potent antibacterial activity against a wide range of bacteria and had low toxicity in humans. Furthermore, its activity was not inhibited by biological constituents such as pus, unlike the synthetic sulfonamides. The discovery of such a powerful antibiotic was unprecedented, and the development of penicillin led to renewed interest in the search for antibiotic compounds with similar efficacy and safety. For their successful development of penicillin, which Fleming had accidentally discovered but could not develop himself, as a therapeutic drug, Ernst Chain and Howard Florey shared the 1945 Nobel Prize in Medicine with Fleming. Florey credited Dubos with pioneering the approach of deliberately and systematically searching for antibacterial compounds, which had led to the discovery of gramicidin and had revived Florey's research in penicillin.. Answer: {'text': [], 'answer_start': []}. Question: |
When was the chemical make-up of bacteria discovered? | Context: Florey and Chain succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945. Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk. The chemical structure of penicillin was determined by Dorothy Crowfoot Hodgkin in 1945. Purified penicillin displayed potent antibacterial activity against a wide range of bacteria and had low toxicity in humans. Furthermore, its activity was not inhibited by biological constituents such as pus, unlike the synthetic sulfonamides. The discovery of such a powerful antibiotic was unprecedented, and the development of penicillin led to renewed interest in the search for antibiotic compounds with similar efficacy and safety. For their successful development of penicillin, which Fleming had accidentally discovered but could not develop himself, as a therapeutic drug, Ernst Chain and Howard Florey shared the 1945 Nobel Prize in Medicine with Fleming. Florey credited Dubos with pioneering the approach of deliberately and systematically searching for antibacterial compounds, which had led to the discovery of gramicidin and had revived Florey's research in penicillin.. Answer: {'text': [], 'answer_start': []}. Question: |
Who discovered the chemical structure of bacteria? | Context: Florey and Chain succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945. Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk. The chemical structure of penicillin was determined by Dorothy Crowfoot Hodgkin in 1945. Purified penicillin displayed potent antibacterial activity against a wide range of bacteria and had low toxicity in humans. Furthermore, its activity was not inhibited by biological constituents such as pus, unlike the synthetic sulfonamides. The discovery of such a powerful antibiotic was unprecedented, and the development of penicillin led to renewed interest in the search for antibiotic compounds with similar efficacy and safety. For their successful development of penicillin, which Fleming had accidentally discovered but could not develop himself, as a therapeutic drug, Ernst Chain and Howard Florey shared the 1945 Nobel Prize in Medicine with Fleming. Florey credited Dubos with pioneering the approach of deliberately and systematically searching for antibacterial compounds, which had led to the discovery of gramicidin and had revived Florey's research in penicillin.. Answer: {'text': [], 'answer_start': []}. Question: |
What do vaccines need to work? | Context: Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases. Vaccines made from attenuated whole cells or lysates have been replaced largely by less reactogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.. Answer: {'text': ['immune modulation or augmentation'], 'answer_start': [17]}. Question: |
What type of vaccines have saved millions of lives? | Context: Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases. Vaccines made from attenuated whole cells or lysates have been replaced largely by less reactogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.. Answer: {'text': ['Antibacterial vaccines'], 'answer_start': [270]}. Question: |
What types of vaccines have been phased out? | Context: Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases. Vaccines made from attenuated whole cells or lysates have been replaced largely by less reactogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.. Answer: {'text': ['Vaccines made from attenuated whole cells or lysates'], 'answer_start': [369]}. Question: |
What do polysaccharides need to work? | Context: Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases. Vaccines made from attenuated whole cells or lysates have been replaced largely by less reactogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.. Answer: {'text': [], 'answer_start': []}. Question: |
What type of polysaccharides have saved millions of lives? | Context: Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases. Vaccines made from attenuated whole cells or lysates have been replaced largely by less reactogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.. Answer: {'text': [], 'answer_start': []}. Question: |
What types of polysaccharides have been phased out? | Context: Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases. Vaccines made from attenuated whole cells or lysates have been replaced largely by less reactogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.. Answer: {'text': [], 'answer_start': []}. Question: |
Vaccines made from what have been replaced by less protein carriers? | Context: Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases. Vaccines made from attenuated whole cells or lysates have been replaced largely by less reactogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.. Answer: {'text': [], 'answer_start': []}. Question: |
What happens when a host includes polysaccharides? | Context: Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases. Vaccines made from attenuated whole cells or lysates have been replaced largely by less reactogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.. Answer: {'text': [], 'answer_start': []}. Question: |
What has been talked about to treat resistant bacteria? | Context: Phage therapy is another option that is being looked into for treating resistant strains of bacteria. The way that researchers are doing this is by infecting pathogenic bacteria with their own viruses, more specifically, bacteriophages. Bacteriophages, also known simply as phages, are precisely bacterial viruses that infect bacteria by disrupting pathogenic bacterium lytic cycles. By disrupting the lytic cycles of bacterium, phages destroy their metabolism, which eventually results in the cell's death. Phages will insert their DNA into the bacterium, allowing their DNA to be transcribed. Once their DNA is transcribed the cell will proceed to make new phages and as soon as they are ready to be released, the cell will lyse. One of the worries about using phages to fight pathogens is that the phages will infect "good" bacteria, or the bacteria that are important in the everyday function of human beings. However, studies have proven that phages are very specific when they target bacteria, which makes researchers confident that bacteriophage therapy is the definite route to defeating antibiotic resistant bacteria.. Answer: {'text': ['Phage therapy'], 'answer_start': [0]}. Question: |
How have researchers been doing this? | Context: Phage therapy is another option that is being looked into for treating resistant strains of bacteria. The way that researchers are doing this is by infecting pathogenic bacteria with their own viruses, more specifically, bacteriophages. Bacteriophages, also known simply as phages, are precisely bacterial viruses that infect bacteria by disrupting pathogenic bacterium lytic cycles. By disrupting the lytic cycles of bacterium, phages destroy their metabolism, which eventually results in the cell's death. Phages will insert their DNA into the bacterium, allowing their DNA to be transcribed. Once their DNA is transcribed the cell will proceed to make new phages and as soon as they are ready to be released, the cell will lyse. One of the worries about using phages to fight pathogens is that the phages will infect "good" bacteria, or the bacteria that are important in the everyday function of human beings. However, studies have proven that phages are very specific when they target bacteria, which makes researchers confident that bacteriophage therapy is the definite route to defeating antibiotic resistant bacteria.. Answer: {'text': ['infecting pathogenic bacteria'], 'answer_start': [148]}. Question: |
What is a worry of using phages? | Context: Phage therapy is another option that is being looked into for treating resistant strains of bacteria. The way that researchers are doing this is by infecting pathogenic bacteria with their own viruses, more specifically, bacteriophages. Bacteriophages, also known simply as phages, are precisely bacterial viruses that infect bacteria by disrupting pathogenic bacterium lytic cycles. By disrupting the lytic cycles of bacterium, phages destroy their metabolism, which eventually results in the cell's death. Phages will insert their DNA into the bacterium, allowing their DNA to be transcribed. Once their DNA is transcribed the cell will proceed to make new phages and as soon as they are ready to be released, the cell will lyse. One of the worries about using phages to fight pathogens is that the phages will infect "good" bacteria, or the bacteria that are important in the everyday function of human beings. However, studies have proven that phages are very specific when they target bacteria, which makes researchers confident that bacteriophage therapy is the definite route to defeating antibiotic resistant bacteria.. Answer: {'text': ['phages will infect "good" bacteria'], 'answer_start': [801]}. Question: |
What has been talked about to treat bateriophages? | Context: Phage therapy is another option that is being looked into for treating resistant strains of bacteria. The way that researchers are doing this is by infecting pathogenic bacteria with their own viruses, more specifically, bacteriophages. Bacteriophages, also known simply as phages, are precisely bacterial viruses that infect bacteria by disrupting pathogenic bacterium lytic cycles. By disrupting the lytic cycles of bacterium, phages destroy their metabolism, which eventually results in the cell's death. Phages will insert their DNA into the bacterium, allowing their DNA to be transcribed. Once their DNA is transcribed the cell will proceed to make new phages and as soon as they are ready to be released, the cell will lyse. One of the worries about using phages to fight pathogens is that the phages will infect "good" bacteria, or the bacteria that are important in the everyday function of human beings. However, studies have proven that phages are very specific when they target bacteria, which makes researchers confident that bacteriophage therapy is the definite route to defeating antibiotic resistant bacteria.. Answer: {'text': [], 'answer_start': []}. Question: |
How have bacterium been doing this? | Context: Phage therapy is another option that is being looked into for treating resistant strains of bacteria. The way that researchers are doing this is by infecting pathogenic bacteria with their own viruses, more specifically, bacteriophages. Bacteriophages, also known simply as phages, are precisely bacterial viruses that infect bacteria by disrupting pathogenic bacterium lytic cycles. By disrupting the lytic cycles of bacterium, phages destroy their metabolism, which eventually results in the cell's death. Phages will insert their DNA into the bacterium, allowing their DNA to be transcribed. Once their DNA is transcribed the cell will proceed to make new phages and as soon as they are ready to be released, the cell will lyse. One of the worries about using phages to fight pathogens is that the phages will infect "good" bacteria, or the bacteria that are important in the everyday function of human beings. However, studies have proven that phages are very specific when they target bacteria, which makes researchers confident that bacteriophage therapy is the definite route to defeating antibiotic resistant bacteria.. Answer: {'text': [], 'answer_start': []}. Question: |
What is a worry of using DNA? | Context: Phage therapy is another option that is being looked into for treating resistant strains of bacteria. The way that researchers are doing this is by infecting pathogenic bacteria with their own viruses, more specifically, bacteriophages. Bacteriophages, also known simply as phages, are precisely bacterial viruses that infect bacteria by disrupting pathogenic bacterium lytic cycles. By disrupting the lytic cycles of bacterium, phages destroy their metabolism, which eventually results in the cell's death. Phages will insert their DNA into the bacterium, allowing their DNA to be transcribed. Once their DNA is transcribed the cell will proceed to make new phages and as soon as they are ready to be released, the cell will lyse. One of the worries about using phages to fight pathogens is that the phages will infect "good" bacteria, or the bacteria that are important in the everyday function of human beings. However, studies have proven that phages are very specific when they target bacteria, which makes researchers confident that bacteriophage therapy is the definite route to defeating antibiotic resistant bacteria.. Answer: {'text': [], 'answer_start': []}. Question: |
What makes researchers confident that phages fight pathogens? | Context: Phage therapy is another option that is being looked into for treating resistant strains of bacteria. The way that researchers are doing this is by infecting pathogenic bacteria with their own viruses, more specifically, bacteriophages. Bacteriophages, also known simply as phages, are precisely bacterial viruses that infect bacteria by disrupting pathogenic bacterium lytic cycles. By disrupting the lytic cycles of bacterium, phages destroy their metabolism, which eventually results in the cell's death. Phages will insert their DNA into the bacterium, allowing their DNA to be transcribed. Once their DNA is transcribed the cell will proceed to make new phages and as soon as they are ready to be released, the cell will lyse. One of the worries about using phages to fight pathogens is that the phages will infect "good" bacteria, or the bacteria that are important in the everyday function of human beings. However, studies have proven that phages are very specific when they target bacteria, which makes researchers confident that bacteriophage therapy is the definite route to defeating antibiotic resistant bacteria.. Answer: {'text': [], 'answer_start': []}. Question: |
By what method do phages destroy antibiotics? | Context: Phage therapy is another option that is being looked into for treating resistant strains of bacteria. The way that researchers are doing this is by infecting pathogenic bacteria with their own viruses, more specifically, bacteriophages. Bacteriophages, also known simply as phages, are precisely bacterial viruses that infect bacteria by disrupting pathogenic bacterium lytic cycles. By disrupting the lytic cycles of bacterium, phages destroy their metabolism, which eventually results in the cell's death. Phages will insert their DNA into the bacterium, allowing their DNA to be transcribed. Once their DNA is transcribed the cell will proceed to make new phages and as soon as they are ready to be released, the cell will lyse. One of the worries about using phages to fight pathogens is that the phages will infect "good" bacteria, or the bacteria that are important in the everyday function of human beings. However, studies have proven that phages are very specific when they target bacteria, which makes researchers confident that bacteriophage therapy is the definite route to defeating antibiotic resistant bacteria.. Answer: {'text': [], 'answer_start': []}. Question: |
How many antibiotics have been created in the last 7 years? | Context: In April 2013, the Infectious Disease Society of America (IDSA) reported that the weak antibiotic pipeline does not match bacteria's increasing ability to develop resistance. Since 2009, only 2 new antibiotics were approved in the United States. The number of new antibiotics approved for marketing per year declines continuously. The report identified seven antibiotics against the Gram-negative bacilli (GNB) currently in phase 2 or phase 3 clinical trials. However, these drugs do not address the entire spectrum of resistance of GNB. Some of these antibiotics are combination of existent treatments:. Answer: {'text': ['2'], 'answer_start': [192]}. Question: |
How many are in the pipelin to fight GNB? | Context: In April 2013, the Infectious Disease Society of America (IDSA) reported that the weak antibiotic pipeline does not match bacteria's increasing ability to develop resistance. Since 2009, only 2 new antibiotics were approved in the United States. The number of new antibiotics approved for marketing per year declines continuously. The report identified seven antibiotics against the Gram-negative bacilli (GNB) currently in phase 2 or phase 3 clinical trials. However, these drugs do not address the entire spectrum of resistance of GNB. Some of these antibiotics are combination of existent treatments:. Answer: {'text': ['seven'], 'answer_start': [353]}. Question: |
What year did the Infectious Disease Society of America say that production of new antibiotics does not keep up with resistance? | Context: In April 2013, the Infectious Disease Society of America (IDSA) reported that the weak antibiotic pipeline does not match bacteria's increasing ability to develop resistance. Since 2009, only 2 new antibiotics were approved in the United States. The number of new antibiotics approved for marketing per year declines continuously. The report identified seven antibiotics against the Gram-negative bacilli (GNB) currently in phase 2 or phase 3 clinical trials. However, these drugs do not address the entire spectrum of resistance of GNB. Some of these antibiotics are combination of existent treatments:. Answer: {'text': ['2013'], 'answer_start': [9]}. Question: |
How many bacilli have been created in the last 7 years? | Context: In April 2013, the Infectious Disease Society of America (IDSA) reported that the weak antibiotic pipeline does not match bacteria's increasing ability to develop resistance. Since 2009, only 2 new antibiotics were approved in the United States. The number of new antibiotics approved for marketing per year declines continuously. The report identified seven antibiotics against the Gram-negative bacilli (GNB) currently in phase 2 or phase 3 clinical trials. However, these drugs do not address the entire spectrum of resistance of GNB. Some of these antibiotics are combination of existent treatments:. Answer: {'text': [], 'answer_start': []}. Question: |
How many are in the pipeline to fight IDSA? | Context: In April 2013, the Infectious Disease Society of America (IDSA) reported that the weak antibiotic pipeline does not match bacteria's increasing ability to develop resistance. Since 2009, only 2 new antibiotics were approved in the United States. The number of new antibiotics approved for marketing per year declines continuously. The report identified seven antibiotics against the Gram-negative bacilli (GNB) currently in phase 2 or phase 3 clinical trials. However, these drugs do not address the entire spectrum of resistance of GNB. Some of these antibiotics are combination of existent treatments:. Answer: {'text': [], 'answer_start': []}. Question: |
What year did the Infectious Diseases of America say that production of GNB does not keep up with resistance? | Context: In April 2013, the Infectious Disease Society of America (IDSA) reported that the weak antibiotic pipeline does not match bacteria's increasing ability to develop resistance. Since 2009, only 2 new antibiotics were approved in the United States. The number of new antibiotics approved for marketing per year declines continuously. The report identified seven antibiotics against the Gram-negative bacilli (GNB) currently in phase 2 or phase 3 clinical trials. However, these drugs do not address the entire spectrum of resistance of GNB. Some of these antibiotics are combination of existent treatments:. Answer: {'text': [], 'answer_start': []}. Question: |
What happens to the umber of new resistance? | Context: In April 2013, the Infectious Disease Society of America (IDSA) reported that the weak antibiotic pipeline does not match bacteria's increasing ability to develop resistance. Since 2009, only 2 new antibiotics were approved in the United States. The number of new antibiotics approved for marketing per year declines continuously. The report identified seven antibiotics against the Gram-negative bacilli (GNB) currently in phase 2 or phase 3 clinical trials. However, these drugs do not address the entire spectrum of resistance of GNB. Some of these antibiotics are combination of existent treatments:. Answer: {'text': [], 'answer_start': []}. Question: |
What drugs address teh entire spectrum of resistance of GNB? | Context: In April 2013, the Infectious Disease Society of America (IDSA) reported that the weak antibiotic pipeline does not match bacteria's increasing ability to develop resistance. Since 2009, only 2 new antibiotics were approved in the United States. The number of new antibiotics approved for marketing per year declines continuously. The report identified seven antibiotics against the Gram-negative bacilli (GNB) currently in phase 2 or phase 3 clinical trials. However, these drugs do not address the entire spectrum of resistance of GNB. Some of these antibiotics are combination of existent treatments:. Answer: {'text': [], 'answer_start': []}. Question: |
Who regulates antibiotic approval? | Context: Possible improvements include clarification of clinical trial regulations by FDA. Furthermore, appropriate economic incentives could persuade pharmaceutical companies to invest in this endeavor. Antibiotic Development to Advance Patient Treatment (ADAPT) Act aims to fast track the drug development to combat the growing threat of 'superbugs'. Under this Act, FDA can approve antibiotics and antifungals treating life-threatening infections based on smaller clinical trials. The CDC will monitor the use of antibiotics and the emerging resistance, and publish the data. The FDA antibiotics labeling process, 'Susceptibility Test Interpretive Criteria for Microbial Organisms' or 'breakpoints', will provide accurate data to healthcare professionals. According to Allan Coukell, senior director for health programs at The Pew Charitable Trusts, "By allowing drug developers to rely on smaller datasets, and clarifying FDA's authority to tolerate a higher level of uncertainty for these drugs when making a risk/benefit calculation, ADAPT would make the clinical trials more feasible.". Answer: {'text': ['FDA'], 'answer_start': [77]}. Question: |
What could help to spur pharmaceuticals to make new antibiotics? | Context: Possible improvements include clarification of clinical trial regulations by FDA. Furthermore, appropriate economic incentives could persuade pharmaceutical companies to invest in this endeavor. Antibiotic Development to Advance Patient Treatment (ADAPT) Act aims to fast track the drug development to combat the growing threat of 'superbugs'. Under this Act, FDA can approve antibiotics and antifungals treating life-threatening infections based on smaller clinical trials. The CDC will monitor the use of antibiotics and the emerging resistance, and publish the data. The FDA antibiotics labeling process, 'Susceptibility Test Interpretive Criteria for Microbial Organisms' or 'breakpoints', will provide accurate data to healthcare professionals. According to Allan Coukell, senior director for health programs at The Pew Charitable Trusts, "By allowing drug developers to rely on smaller datasets, and clarifying FDA's authority to tolerate a higher level of uncertainty for these drugs when making a risk/benefit calculation, ADAPT would make the clinical trials more feasible.". Answer: {'text': ['economic incentives'], 'answer_start': [107]}. Question: |
What are resistant bacteria called in the media? | Context: Possible improvements include clarification of clinical trial regulations by FDA. Furthermore, appropriate economic incentives could persuade pharmaceutical companies to invest in this endeavor. Antibiotic Development to Advance Patient Treatment (ADAPT) Act aims to fast track the drug development to combat the growing threat of 'superbugs'. Under this Act, FDA can approve antibiotics and antifungals treating life-threatening infections based on smaller clinical trials. The CDC will monitor the use of antibiotics and the emerging resistance, and publish the data. The FDA antibiotics labeling process, 'Susceptibility Test Interpretive Criteria for Microbial Organisms' or 'breakpoints', will provide accurate data to healthcare professionals. According to Allan Coukell, senior director for health programs at The Pew Charitable Trusts, "By allowing drug developers to rely on smaller datasets, and clarifying FDA's authority to tolerate a higher level of uncertainty for these drugs when making a risk/benefit calculation, ADAPT would make the clinical trials more feasible.". Answer: {'text': ['superbugs'], 'answer_start': [332]}. Question: |
Who is a director at the Pew Charitable Trusts? | Context: Possible improvements include clarification of clinical trial regulations by FDA. Furthermore, appropriate economic incentives could persuade pharmaceutical companies to invest in this endeavor. Antibiotic Development to Advance Patient Treatment (ADAPT) Act aims to fast track the drug development to combat the growing threat of 'superbugs'. Under this Act, FDA can approve antibiotics and antifungals treating life-threatening infections based on smaller clinical trials. The CDC will monitor the use of antibiotics and the emerging resistance, and publish the data. The FDA antibiotics labeling process, 'Susceptibility Test Interpretive Criteria for Microbial Organisms' or 'breakpoints', will provide accurate data to healthcare professionals. According to Allan Coukell, senior director for health programs at The Pew Charitable Trusts, "By allowing drug developers to rely on smaller datasets, and clarifying FDA's authority to tolerate a higher level of uncertainty for these drugs when making a risk/benefit calculation, ADAPT would make the clinical trials more feasible.". Answer: {'text': ['Allan Coukell,'], 'answer_start': [763]}. Question: |
Who regulates infection approval? | Context: Possible improvements include clarification of clinical trial regulations by FDA. Furthermore, appropriate economic incentives could persuade pharmaceutical companies to invest in this endeavor. Antibiotic Development to Advance Patient Treatment (ADAPT) Act aims to fast track the drug development to combat the growing threat of 'superbugs'. Under this Act, FDA can approve antibiotics and antifungals treating life-threatening infections based on smaller clinical trials. The CDC will monitor the use of antibiotics and the emerging resistance, and publish the data. The FDA antibiotics labeling process, 'Susceptibility Test Interpretive Criteria for Microbial Organisms' or 'breakpoints', will provide accurate data to healthcare professionals. According to Allan Coukell, senior director for health programs at The Pew Charitable Trusts, "By allowing drug developers to rely on smaller datasets, and clarifying FDA's authority to tolerate a higher level of uncertainty for these drugs when making a risk/benefit calculation, ADAPT would make the clinical trials more feasible.". Answer: {'text': [], 'answer_start': []}. Question: |
What could help to spur pharmaceuticals to make new infections? | Context: Possible improvements include clarification of clinical trial regulations by FDA. Furthermore, appropriate economic incentives could persuade pharmaceutical companies to invest in this endeavor. Antibiotic Development to Advance Patient Treatment (ADAPT) Act aims to fast track the drug development to combat the growing threat of 'superbugs'. Under this Act, FDA can approve antibiotics and antifungals treating life-threatening infections based on smaller clinical trials. The CDC will monitor the use of antibiotics and the emerging resistance, and publish the data. The FDA antibiotics labeling process, 'Susceptibility Test Interpretive Criteria for Microbial Organisms' or 'breakpoints', will provide accurate data to healthcare professionals. According to Allan Coukell, senior director for health programs at The Pew Charitable Trusts, "By allowing drug developers to rely on smaller datasets, and clarifying FDA's authority to tolerate a higher level of uncertainty for these drugs when making a risk/benefit calculation, ADAPT would make the clinical trials more feasible.". Answer: {'text': [], 'answer_start': []}. Question: |
Who is a director at the FDA? | Context: Possible improvements include clarification of clinical trial regulations by FDA. Furthermore, appropriate economic incentives could persuade pharmaceutical companies to invest in this endeavor. Antibiotic Development to Advance Patient Treatment (ADAPT) Act aims to fast track the drug development to combat the growing threat of 'superbugs'. Under this Act, FDA can approve antibiotics and antifungals treating life-threatening infections based on smaller clinical trials. The CDC will monitor the use of antibiotics and the emerging resistance, and publish the data. The FDA antibiotics labeling process, 'Susceptibility Test Interpretive Criteria for Microbial Organisms' or 'breakpoints', will provide accurate data to healthcare professionals. According to Allan Coukell, senior director for health programs at The Pew Charitable Trusts, "By allowing drug developers to rely on smaller datasets, and clarifying FDA's authority to tolerate a higher level of uncertainty for these drugs when making a risk/benefit calculation, ADAPT would make the clinical trials more feasible.". Answer: {'text': [], 'answer_start': []}. Question: |
Who will monitor the use of economic incentives? | Context: Possible improvements include clarification of clinical trial regulations by FDA. Furthermore, appropriate economic incentives could persuade pharmaceutical companies to invest in this endeavor. Antibiotic Development to Advance Patient Treatment (ADAPT) Act aims to fast track the drug development to combat the growing threat of 'superbugs'. Under this Act, FDA can approve antibiotics and antifungals treating life-threatening infections based on smaller clinical trials. The CDC will monitor the use of antibiotics and the emerging resistance, and publish the data. The FDA antibiotics labeling process, 'Susceptibility Test Interpretive Criteria for Microbial Organisms' or 'breakpoints', will provide accurate data to healthcare professionals. According to Allan Coukell, senior director for health programs at The Pew Charitable Trusts, "By allowing drug developers to rely on smaller datasets, and clarifying FDA's authority to tolerate a higher level of uncertainty for these drugs when making a risk/benefit calculation, ADAPT would make the clinical trials more feasible.". Answer: {'text': [], 'answer_start': []}. Question: |
Who aims to fast track healthcare professionals? | Context: Possible improvements include clarification of clinical trial regulations by FDA. Furthermore, appropriate economic incentives could persuade pharmaceutical companies to invest in this endeavor. Antibiotic Development to Advance Patient Treatment (ADAPT) Act aims to fast track the drug development to combat the growing threat of 'superbugs'. Under this Act, FDA can approve antibiotics and antifungals treating life-threatening infections based on smaller clinical trials. The CDC will monitor the use of antibiotics and the emerging resistance, and publish the data. The FDA antibiotics labeling process, 'Susceptibility Test Interpretive Criteria for Microbial Organisms' or 'breakpoints', will provide accurate data to healthcare professionals. According to Allan Coukell, senior director for health programs at The Pew Charitable Trusts, "By allowing drug developers to rely on smaller datasets, and clarifying FDA's authority to tolerate a higher level of uncertainty for these drugs when making a risk/benefit calculation, ADAPT would make the clinical trials more feasible.". Answer: {'text': [], 'answer_start': []}. Question: |
In 1059, who was responsible for electing the pope? | Context: In 1059, the right of electing the pope was reserved to the principal clergy of Rome and the bishops of the seven suburbicarian sees. In the 12th century the practice of appointing ecclesiastics from outside Rome as cardinals began, with each of them assigned a church in Rome as his titular church or linked with one of the suburbicarian dioceses, while still being incardinated in a diocese other than that of Rome.[citation needed]. Answer: {'text': ['the principal clergy of Rome and the bishops of the seven suburbicarian sees.'], 'answer_start': [56]}. Question: |
What were the cardinals assigned? | Context: In 1059, the right of electing the pope was reserved to the principal clergy of Rome and the bishops of the seven suburbicarian sees. In the 12th century the practice of appointing ecclesiastics from outside Rome as cardinals began, with each of them assigned a church in Rome as his titular church or linked with one of the suburbicarian dioceses, while still being incardinated in a diocese other than that of Rome.[citation needed]. Answer: {'text': ['a church in Rome as his titular church or linked with one of the suburbicarian dioceses'], 'answer_start': [260]}. Question: |
Who did not have the right of electing the pope in 1059? | Context: In 1059, the right of electing the pope was reserved to the principal clergy of Rome and the bishops of the seven suburbicarian sees. In the 12th century the practice of appointing ecclesiastics from outside Rome as cardinals began, with each of them assigned a church in Rome as his titular church or linked with one of the suburbicarian dioceses, while still being incardinated in a diocese other than that of Rome.[citation needed]. Answer: {'text': [], 'answer_start': []}. Question: |
Who held the right to appoint ecclesiastics from outside Rome in 1059? | Context: In 1059, the right of electing the pope was reserved to the principal clergy of Rome and the bishops of the seven suburbicarian sees. In the 12th century the practice of appointing ecclesiastics from outside Rome as cardinals began, with each of them assigned a church in Rome as his titular church or linked with one of the suburbicarian dioceses, while still being incardinated in a diocese other than that of Rome.[citation needed]. Answer: {'text': [], 'answer_start': []}. Question: |
What were the cardinals not assigned? | Context: In 1059, the right of electing the pope was reserved to the principal clergy of Rome and the bishops of the seven suburbicarian sees. In the 12th century the practice of appointing ecclesiastics from outside Rome as cardinals began, with each of them assigned a church in Rome as his titular church or linked with one of the suburbicarian dioceses, while still being incardinated in a diocese other than that of Rome.[citation needed]. Answer: {'text': [], 'answer_start': []}. Question: |
Where outside of Rome were the ecclesiastics assigned? | Context: In 1059, the right of electing the pope was reserved to the principal clergy of Rome and the bishops of the seven suburbicarian sees. In the 12th century the practice of appointing ecclesiastics from outside Rome as cardinals began, with each of them assigned a church in Rome as his titular church or linked with one of the suburbicarian dioceses, while still being incardinated in a diocese other than that of Rome.[citation needed]. Answer: {'text': [], 'answer_start': []}. Question: |
At one time, Priest permanently were assigned to a church were referred to as? | Context: The term cardinal at one time applied to any priest permanently assigned or incardinated to a church, or specifically to the senior priest of an important church, based on the Latin cardo (hinge), meaning "principal" or "chief". The term was applied in this sense as early as the ninth century to the priests of the tituli (parishes) of the diocese of Rome. The Church of England retains an instance of this origin of the title, which is held by the two senior members of the College of Minor Canons of St Paul's Cathedral.. Answer: {'text': ['cardinal'], 'answer_start': [9]}. Question: |
How early was this term used? | Context: The term cardinal at one time applied to any priest permanently assigned or incardinated to a church, or specifically to the senior priest of an important church, based on the Latin cardo (hinge), meaning "principal" or "chief". The term was applied in this sense as early as the ninth century to the priests of the tituli (parishes) of the diocese of Rome. The Church of England retains an instance of this origin of the title, which is held by the two senior members of the College of Minor Canons of St Paul's Cathedral.. Answer: {'text': ['ninth century'], 'answer_start': [280]}. Question: |
The Church of England uses what term that is held by two senior members of the College of Minor Canons of St. Pauls Catherdral? | Context: The term cardinal at one time applied to any priest permanently assigned or incardinated to a church, or specifically to the senior priest of an important church, based on the Latin cardo (hinge), meaning "principal" or "chief". The term was applied in this sense as early as the ninth century to the priests of the tituli (parishes) of the diocese of Rome. The Church of England retains an instance of this origin of the title, which is held by the two senior members of the College of Minor Canons of St Paul's Cathedral.. Answer: {'text': ['tituli'], 'answer_start': [316]}. Question: |
What Latin word does "cardinal" come from? | Context: The term cardinal at one time applied to any priest permanently assigned or incardinated to a church, or specifically to the senior priest of an important church, based on the Latin cardo (hinge), meaning "principal" or "chief". The term was applied in this sense as early as the ninth century to the priests of the tituli (parishes) of the diocese of Rome. The Church of England retains an instance of this origin of the title, which is held by the two senior members of the College of Minor Canons of St Paul's Cathedral.. Answer: {'text': ['cardo'], 'answer_start': [182]}. Question: |
Which church still holds on to the original meaning of "cardinal" from the above Latin word? | Context: The term cardinal at one time applied to any priest permanently assigned or incardinated to a church, or specifically to the senior priest of an important church, based on the Latin cardo (hinge), meaning "principal" or "chief". The term was applied in this sense as early as the ninth century to the priests of the tituli (parishes) of the diocese of Rome. The Church of England retains an instance of this origin of the title, which is held by the two senior members of the College of Minor Canons of St Paul's Cathedral.. Answer: {'text': ['The Church of England'], 'answer_start': [358]}. Question: |
What does the Latin cardo not mean? | Context: The term cardinal at one time applied to any priest permanently assigned or incardinated to a church, or specifically to the senior priest of an important church, based on the Latin cardo (hinge), meaning "principal" or "chief". The term was applied in this sense as early as the ninth century to the priests of the tituli (parishes) of the diocese of Rome. The Church of England retains an instance of this origin of the title, which is held by the two senior members of the College of Minor Canons of St Paul's Cathedral.. Answer: {'text': [], 'answer_start': []}. Question: |
What is the term applied to any priest temporarily assigned or incardinated to a church? | Context: The term cardinal at one time applied to any priest permanently assigned or incardinated to a church, or specifically to the senior priest of an important church, based on the Latin cardo (hinge), meaning "principal" or "chief". The term was applied in this sense as early as the ninth century to the priests of the tituli (parishes) of the diocese of Rome. The Church of England retains an instance of this origin of the title, which is held by the two senior members of the College of Minor Canons of St Paul's Cathedral.. Answer: {'text': [], 'answer_start': []}. Question: |
What term was applied as early as the eighth century to the priests of the tituli of the diocese of Rome? | Context: The term cardinal at one time applied to any priest permanently assigned or incardinated to a church, or specifically to the senior priest of an important church, based on the Latin cardo (hinge), meaning "principal" or "chief". The term was applied in this sense as early as the ninth century to the priests of the tituli (parishes) of the diocese of Rome. The Church of England retains an instance of this origin of the title, which is held by the two senior members of the College of Minor Canons of St Paul's Cathedral.. Answer: {'text': [], 'answer_start': []}. Question: |
What term was used by the Church of France that is held by two senior members of the College of Minor Canon of St. Paul's Catherdral? | Context: The term cardinal at one time applied to any priest permanently assigned or incardinated to a church, or specifically to the senior priest of an important church, based on the Latin cardo (hinge), meaning "principal" or "chief". The term was applied in this sense as early as the ninth century to the priests of the tituli (parishes) of the diocese of Rome. The Church of England retains an instance of this origin of the title, which is held by the two senior members of the College of Minor Canons of St Paul's Cathedral.. Answer: {'text': [], 'answer_start': []}. Question: |
Which church maintains the original meaning of the Greek word "cardo"? | Context: The term cardinal at one time applied to any priest permanently assigned or incardinated to a church, or specifically to the senior priest of an important church, based on the Latin cardo (hinge), meaning "principal" or "chief". The term was applied in this sense as early as the ninth century to the priests of the tituli (parishes) of the diocese of Rome. The Church of England retains an instance of this origin of the title, which is held by the two senior members of the College of Minor Canons of St Paul's Cathedral.. Answer: {'text': [], 'answer_start': []}. Question: |
Who were the first people to be called cardinals in Rome? | Context: There is disagreement about the origin of the term, but general consensus that "cardinalis" from the word cardo (meaning 'pivot' or 'hinge') was first used in late antiquity to designate a bishop or priest who was incorporated into a church for which he had not originally been ordained. In Rome the first persons to be called cardinals were the deacons of the seven regions of the city at the beginning of the 6th century, when the word began to mean “principal,” “eminent,” or "superior." The name was also given to the senior priest in each of the "title" churches (the parish churches) of Rome and to the bishops of the seven sees surrounding the city. By the 8th century the Roman cardinals constituted a privileged class among the Roman clergy. They took part in the administration of the church of Rome and in the papal liturgy. By decree of a synod of 769, only a cardinal was eligible to become pope. In 1059, during the pontificate of Nicholas II, cardinals were given the right to elect the pope under the Papal Bull In nomine Domini. For a time this power was assigned exclusively to the cardinal bishops, but the Third Lateran Council in 1179 gave back the right to the whole body of cardinals. Cardinals were granted the privilege of wearing the red hat by Pope Innocent IV in 1244.. Answer: {'text': ['the deacons of the seven regions of the city'], 'answer_start': [342]}. Question: |
When were the Roman cardinals perceived as a privleged class among the Roman clergy? | Context: There is disagreement about the origin of the term, but general consensus that "cardinalis" from the word cardo (meaning 'pivot' or 'hinge') was first used in late antiquity to designate a bishop or priest who was incorporated into a church for which he had not originally been ordained. In Rome the first persons to be called cardinals were the deacons of the seven regions of the city at the beginning of the 6th century, when the word began to mean “principal,” “eminent,” or "superior." The name was also given to the senior priest in each of the "title" churches (the parish churches) of Rome and to the bishops of the seven sees surrounding the city. By the 8th century the Roman cardinals constituted a privileged class among the Roman clergy. They took part in the administration of the church of Rome and in the papal liturgy. By decree of a synod of 769, only a cardinal was eligible to become pope. In 1059, during the pontificate of Nicholas II, cardinals were given the right to elect the pope under the Papal Bull In nomine Domini. For a time this power was assigned exclusively to the cardinal bishops, but the Third Lateran Council in 1179 gave back the right to the whole body of cardinals. Cardinals were granted the privilege of wearing the red hat by Pope Innocent IV in 1244.. Answer: {'text': ['8th century'], 'answer_start': [664]}. Question: |
What year did the ruling "only a cardinal was eligible to become pope" come in effect? | Context: There is disagreement about the origin of the term, but general consensus that "cardinalis" from the word cardo (meaning 'pivot' or 'hinge') was first used in late antiquity to designate a bishop or priest who was incorporated into a church for which he had not originally been ordained. In Rome the first persons to be called cardinals were the deacons of the seven regions of the city at the beginning of the 6th century, when the word began to mean “principal,” “eminent,” or "superior." The name was also given to the senior priest in each of the "title" churches (the parish churches) of Rome and to the bishops of the seven sees surrounding the city. By the 8th century the Roman cardinals constituted a privileged class among the Roman clergy. They took part in the administration of the church of Rome and in the papal liturgy. By decree of a synod of 769, only a cardinal was eligible to become pope. In 1059, during the pontificate of Nicholas II, cardinals were given the right to elect the pope under the Papal Bull In nomine Domini. For a time this power was assigned exclusively to the cardinal bishops, but the Third Lateran Council in 1179 gave back the right to the whole body of cardinals. Cardinals were granted the privilege of wearing the red hat by Pope Innocent IV in 1244.. Answer: {'text': ['769'], 'answer_start': [860]}. Question: |
Who gave cardinals the right to elect the pope under the Papal Bull In nomine Domini? | Context: There is disagreement about the origin of the term, but general consensus that "cardinalis" from the word cardo (meaning 'pivot' or 'hinge') was first used in late antiquity to designate a bishop or priest who was incorporated into a church for which he had not originally been ordained. In Rome the first persons to be called cardinals were the deacons of the seven regions of the city at the beginning of the 6th century, when the word began to mean “principal,” “eminent,” or "superior." The name was also given to the senior priest in each of the "title" churches (the parish churches) of Rome and to the bishops of the seven sees surrounding the city. By the 8th century the Roman cardinals constituted a privileged class among the Roman clergy. They took part in the administration of the church of Rome and in the papal liturgy. By decree of a synod of 769, only a cardinal was eligible to become pope. In 1059, during the pontificate of Nicholas II, cardinals were given the right to elect the pope under the Papal Bull In nomine Domini. For a time this power was assigned exclusively to the cardinal bishops, but the Third Lateran Council in 1179 gave back the right to the whole body of cardinals. Cardinals were granted the privilege of wearing the red hat by Pope Innocent IV in 1244.. Answer: {'text': ['Nicholas II'], 'answer_start': [945]}. Question: |
What was it that gave cardinals the right to elect the pope? | Context: There is disagreement about the origin of the term, but general consensus that "cardinalis" from the word cardo (meaning 'pivot' or 'hinge') was first used in late antiquity to designate a bishop or priest who was incorporated into a church for which he had not originally been ordained. In Rome the first persons to be called cardinals were the deacons of the seven regions of the city at the beginning of the 6th century, when the word began to mean “principal,” “eminent,” or "superior." The name was also given to the senior priest in each of the "title" churches (the parish churches) of Rome and to the bishops of the seven sees surrounding the city. By the 8th century the Roman cardinals constituted a privileged class among the Roman clergy. They took part in the administration of the church of Rome and in the papal liturgy. By decree of a synod of 769, only a cardinal was eligible to become pope. In 1059, during the pontificate of Nicholas II, cardinals were given the right to elect the pope under the Papal Bull In nomine Domini. For a time this power was assigned exclusively to the cardinal bishops, but the Third Lateran Council in 1179 gave back the right to the whole body of cardinals. Cardinals were granted the privilege of wearing the red hat by Pope Innocent IV in 1244.. Answer: {'text': ['the Papal Bull In nomine Domini'], 'answer_start': [1013]}. Question: |
In what year did the pope allow cardinals to wear the red hats? | Context: There is disagreement about the origin of the term, but general consensus that "cardinalis" from the word cardo (meaning 'pivot' or 'hinge') was first used in late antiquity to designate a bishop or priest who was incorporated into a church for which he had not originally been ordained. In Rome the first persons to be called cardinals were the deacons of the seven regions of the city at the beginning of the 6th century, when the word began to mean “principal,” “eminent,” or "superior." The name was also given to the senior priest in each of the "title" churches (the parish churches) of Rome and to the bishops of the seven sees surrounding the city. By the 8th century the Roman cardinals constituted a privileged class among the Roman clergy. They took part in the administration of the church of Rome and in the papal liturgy. By decree of a synod of 769, only a cardinal was eligible to become pope. In 1059, during the pontificate of Nicholas II, cardinals were given the right to elect the pope under the Papal Bull In nomine Domini. For a time this power was assigned exclusively to the cardinal bishops, but the Third Lateran Council in 1179 gave back the right to the whole body of cardinals. Cardinals were granted the privilege of wearing the red hat by Pope Innocent IV in 1244.. Answer: {'text': ['1244'], 'answer_start': [1291]}. Question: |
Who was the pope who gave cardinals the right to wear the hats? | Context: There is disagreement about the origin of the term, but general consensus that "cardinalis" from the word cardo (meaning 'pivot' or 'hinge') was first used in late antiquity to designate a bishop or priest who was incorporated into a church for which he had not originally been ordained. In Rome the first persons to be called cardinals were the deacons of the seven regions of the city at the beginning of the 6th century, when the word began to mean “principal,” “eminent,” or "superior." The name was also given to the senior priest in each of the "title" churches (the parish churches) of Rome and to the bishops of the seven sees surrounding the city. By the 8th century the Roman cardinals constituted a privileged class among the Roman clergy. They took part in the administration of the church of Rome and in the papal liturgy. By decree of a synod of 769, only a cardinal was eligible to become pope. In 1059, during the pontificate of Nicholas II, cardinals were given the right to elect the pope under the Papal Bull In nomine Domini. For a time this power was assigned exclusively to the cardinal bishops, but the Third Lateran Council in 1179 gave back the right to the whole body of cardinals. Cardinals were granted the privilege of wearing the red hat by Pope Innocent IV in 1244.. Answer: {'text': ['Pope Innocent IV'], 'answer_start': [1271]}. Question: |
Who were the first persons to be called cardinals at the beginning of the 7th century in Rome? | Context: There is disagreement about the origin of the term, but general consensus that "cardinalis" from the word cardo (meaning 'pivot' or 'hinge') was first used in late antiquity to designate a bishop or priest who was incorporated into a church for which he had not originally been ordained. In Rome the first persons to be called cardinals were the deacons of the seven regions of the city at the beginning of the 6th century, when the word began to mean “principal,” “eminent,” or "superior." The name was also given to the senior priest in each of the "title" churches (the parish churches) of Rome and to the bishops of the seven sees surrounding the city. By the 8th century the Roman cardinals constituted a privileged class among the Roman clergy. They took part in the administration of the church of Rome and in the papal liturgy. By decree of a synod of 769, only a cardinal was eligible to become pope. In 1059, during the pontificate of Nicholas II, cardinals were given the right to elect the pope under the Papal Bull In nomine Domini. For a time this power was assigned exclusively to the cardinal bishops, but the Third Lateran Council in 1179 gave back the right to the whole body of cardinals. Cardinals were granted the privilege of wearing the red hat by Pope Innocent IV in 1244.. Answer: {'text': [], 'answer_start': []}. Question: |
What did the word cardinal begin to mean at the beginning of the 8th century? | Context: There is disagreement about the origin of the term, but general consensus that "cardinalis" from the word cardo (meaning 'pivot' or 'hinge') was first used in late antiquity to designate a bishop or priest who was incorporated into a church for which he had not originally been ordained. In Rome the first persons to be called cardinals were the deacons of the seven regions of the city at the beginning of the 6th century, when the word began to mean “principal,” “eminent,” or "superior." The name was also given to the senior priest in each of the "title" churches (the parish churches) of Rome and to the bishops of the seven sees surrounding the city. By the 8th century the Roman cardinals constituted a privileged class among the Roman clergy. They took part in the administration of the church of Rome and in the papal liturgy. By decree of a synod of 769, only a cardinal was eligible to become pope. In 1059, during the pontificate of Nicholas II, cardinals were given the right to elect the pope under the Papal Bull In nomine Domini. For a time this power was assigned exclusively to the cardinal bishops, but the Third Lateran Council in 1179 gave back the right to the whole body of cardinals. Cardinals were granted the privilege of wearing the red hat by Pope Innocent IV in 1244.. Answer: {'text': [], 'answer_start': []}. Question: |
When were the Roman cardinals considered part of the peasant class? | Context: There is disagreement about the origin of the term, but general consensus that "cardinalis" from the word cardo (meaning 'pivot' or 'hinge') was first used in late antiquity to designate a bishop or priest who was incorporated into a church for which he had not originally been ordained. In Rome the first persons to be called cardinals were the deacons of the seven regions of the city at the beginning of the 6th century, when the word began to mean “principal,” “eminent,” or "superior." The name was also given to the senior priest in each of the "title" churches (the parish churches) of Rome and to the bishops of the seven sees surrounding the city. By the 8th century the Roman cardinals constituted a privileged class among the Roman clergy. They took part in the administration of the church of Rome and in the papal liturgy. By decree of a synod of 769, only a cardinal was eligible to become pope. In 1059, during the pontificate of Nicholas II, cardinals were given the right to elect the pope under the Papal Bull In nomine Domini. For a time this power was assigned exclusively to the cardinal bishops, but the Third Lateran Council in 1179 gave back the right to the whole body of cardinals. Cardinals were granted the privilege of wearing the red hat by Pope Innocent IV in 1244.. Answer: {'text': [], 'answer_start': []}. Question: |
In what year was the pope eligible to become a cardinal? | Context: There is disagreement about the origin of the term, but general consensus that "cardinalis" from the word cardo (meaning 'pivot' or 'hinge') was first used in late antiquity to designate a bishop or priest who was incorporated into a church for which he had not originally been ordained. In Rome the first persons to be called cardinals were the deacons of the seven regions of the city at the beginning of the 6th century, when the word began to mean “principal,” “eminent,” or "superior." The name was also given to the senior priest in each of the "title" churches (the parish churches) of Rome and to the bishops of the seven sees surrounding the city. By the 8th century the Roman cardinals constituted a privileged class among the Roman clergy. They took part in the administration of the church of Rome and in the papal liturgy. By decree of a synod of 769, only a cardinal was eligible to become pope. In 1059, during the pontificate of Nicholas II, cardinals were given the right to elect the pope under the Papal Bull In nomine Domini. For a time this power was assigned exclusively to the cardinal bishops, but the Third Lateran Council in 1179 gave back the right to the whole body of cardinals. Cardinals were granted the privilege of wearing the red hat by Pope Innocent IV in 1244.. Answer: {'text': [], 'answer_start': []}. Question: |
Who rescinded the right of the whole body of cardinals to elect the pope in 1179? | Context: There is disagreement about the origin of the term, but general consensus that "cardinalis" from the word cardo (meaning 'pivot' or 'hinge') was first used in late antiquity to designate a bishop or priest who was incorporated into a church for which he had not originally been ordained. In Rome the first persons to be called cardinals were the deacons of the seven regions of the city at the beginning of the 6th century, when the word began to mean “principal,” “eminent,” or "superior." The name was also given to the senior priest in each of the "title" churches (the parish churches) of Rome and to the bishops of the seven sees surrounding the city. By the 8th century the Roman cardinals constituted a privileged class among the Roman clergy. They took part in the administration of the church of Rome and in the papal liturgy. By decree of a synod of 769, only a cardinal was eligible to become pope. In 1059, during the pontificate of Nicholas II, cardinals were given the right to elect the pope under the Papal Bull In nomine Domini. For a time this power was assigned exclusively to the cardinal bishops, but the Third Lateran Council in 1179 gave back the right to the whole body of cardinals. Cardinals were granted the privilege of wearing the red hat by Pope Innocent IV in 1244.. Answer: {'text': [], 'answer_start': []}. Question: |
What term was given to certain church men of honor? | Context: In cities other than Rome, the name cardinal began to be applied to certain church men as a mark of honour. The earliest example of this occurs in a letter sent by Pope Zacharias in 747 to Pippin III (the Short), ruler of the Franks, in which Zacharias applied the title to the priests of Paris to distinguish them from country clergy. This meaning of the word spread rapidly, and from the 9th century various episcopal cities had a special class among the clergy known as cardinals. The use of the title was reserved for the cardinals of Rome in 1567 by Pius V.. Answer: {'text': ['cardinal'], 'answer_start': [36]}. Question: |
When is the earliest date of using the term cardinal as honorable church men used? | Context: In cities other than Rome, the name cardinal began to be applied to certain church men as a mark of honour. The earliest example of this occurs in a letter sent by Pope Zacharias in 747 to Pippin III (the Short), ruler of the Franks, in which Zacharias applied the title to the priests of Paris to distinguish them from country clergy. This meaning of the word spread rapidly, and from the 9th century various episcopal cities had a special class among the clergy known as cardinals. The use of the title was reserved for the cardinals of Rome in 1567 by Pius V.. Answer: {'text': ['747'], 'answer_start': [182]}. Question: |
When was the title of cardinal reserved for the cardinals of Rome by Pius V? | Context: In cities other than Rome, the name cardinal began to be applied to certain church men as a mark of honour. The earliest example of this occurs in a letter sent by Pope Zacharias in 747 to Pippin III (the Short), ruler of the Franks, in which Zacharias applied the title to the priests of Paris to distinguish them from country clergy. This meaning of the word spread rapidly, and from the 9th century various episcopal cities had a special class among the clergy known as cardinals. The use of the title was reserved for the cardinals of Rome in 1567 by Pius V.. Answer: {'text': ['1567'], 'answer_start': [547]}. Question: |
In regards to the word "cardinal" being used in cities other than Rome, who sent a letter to Pippin III? | Context: In cities other than Rome, the name cardinal began to be applied to certain church men as a mark of honour. The earliest example of this occurs in a letter sent by Pope Zacharias in 747 to Pippin III (the Short), ruler of the Franks, in which Zacharias applied the title to the priests of Paris to distinguish them from country clergy. This meaning of the word spread rapidly, and from the 9th century various episcopal cities had a special class among the clergy known as cardinals. The use of the title was reserved for the cardinals of Rome in 1567 by Pius V.. Answer: {'text': ['Pope Zacharias'], 'answer_start': [164]}. Question: |
In what year was the letter sent? | Context: In cities other than Rome, the name cardinal began to be applied to certain church men as a mark of honour. The earliest example of this occurs in a letter sent by Pope Zacharias in 747 to Pippin III (the Short), ruler of the Franks, in which Zacharias applied the title to the priests of Paris to distinguish them from country clergy. This meaning of the word spread rapidly, and from the 9th century various episcopal cities had a special class among the clergy known as cardinals. The use of the title was reserved for the cardinals of Rome in 1567 by Pius V.. Answer: {'text': ['747'], 'answer_start': [182]}. Question: |
Which pope declared that cardinals would be from Rome? | Context: In cities other than Rome, the name cardinal began to be applied to certain church men as a mark of honour. The earliest example of this occurs in a letter sent by Pope Zacharias in 747 to Pippin III (the Short), ruler of the Franks, in which Zacharias applied the title to the priests of Paris to distinguish them from country clergy. This meaning of the word spread rapidly, and from the 9th century various episcopal cities had a special class among the clergy known as cardinals. The use of the title was reserved for the cardinals of Rome in 1567 by Pius V.. Answer: {'text': ['Pius V.'], 'answer_start': [555]}. Question: |
In what year did the pope make the declaration? | Context: In cities other than Rome, the name cardinal began to be applied to certain church men as a mark of honour. The earliest example of this occurs in a letter sent by Pope Zacharias in 747 to Pippin III (the Short), ruler of the Franks, in which Zacharias applied the title to the priests of Paris to distinguish them from country clergy. This meaning of the word spread rapidly, and from the 9th century various episcopal cities had a special class among the clergy known as cardinals. The use of the title was reserved for the cardinals of Rome in 1567 by Pius V.. Answer: {'text': ['1567'], 'answer_start': [547]}. Question: |
What term was applied to certain political leaders as a mark of honor? | Context: In cities other than Rome, the name cardinal began to be applied to certain church men as a mark of honour. The earliest example of this occurs in a letter sent by Pope Zacharias in 747 to Pippin III (the Short), ruler of the Franks, in which Zacharias applied the title to the priests of Paris to distinguish them from country clergy. This meaning of the word spread rapidly, and from the 9th century various episcopal cities had a special class among the clergy known as cardinals. The use of the title was reserved for the cardinals of Rome in 1567 by Pius V.. Answer: {'text': [], 'answer_start': []}. Question: |
What did Pippin III call priests of Paris to distinguish them from county clergy? | Context: In cities other than Rome, the name cardinal began to be applied to certain church men as a mark of honour. The earliest example of this occurs in a letter sent by Pope Zacharias in 747 to Pippin III (the Short), ruler of the Franks, in which Zacharias applied the title to the priests of Paris to distinguish them from country clergy. This meaning of the word spread rapidly, and from the 9th century various episcopal cities had a special class among the clergy known as cardinals. The use of the title was reserved for the cardinals of Rome in 1567 by Pius V.. Answer: {'text': [], 'answer_start': []}. Question: |
What century did the term cardinal spread quickly throughout various Muslim cities? | Context: In cities other than Rome, the name cardinal began to be applied to certain church men as a mark of honour. The earliest example of this occurs in a letter sent by Pope Zacharias in 747 to Pippin III (the Short), ruler of the Franks, in which Zacharias applied the title to the priests of Paris to distinguish them from country clergy. This meaning of the word spread rapidly, and from the 9th century various episcopal cities had a special class among the clergy known as cardinals. The use of the title was reserved for the cardinals of Rome in 1567 by Pius V.. Answer: {'text': [], 'answer_start': []}. Question: |
In what year did Pope Zacharias reserve the title for the cardinals of Rome? | Context: In cities other than Rome, the name cardinal began to be applied to certain church men as a mark of honour. The earliest example of this occurs in a letter sent by Pope Zacharias in 747 to Pippin III (the Short), ruler of the Franks, in which Zacharias applied the title to the priests of Paris to distinguish them from country clergy. This meaning of the word spread rapidly, and from the 9th century various episcopal cities had a special class among the clergy known as cardinals. The use of the title was reserved for the cardinals of Rome in 1567 by Pius V.. Answer: {'text': [], 'answer_start': []}. Question: |
Who had a special class among clergy known as priests in the 9th century? | Context: In cities other than Rome, the name cardinal began to be applied to certain church men as a mark of honour. The earliest example of this occurs in a letter sent by Pope Zacharias in 747 to Pippin III (the Short), ruler of the Franks, in which Zacharias applied the title to the priests of Paris to distinguish them from country clergy. This meaning of the word spread rapidly, and from the 9th century various episcopal cities had a special class among the clergy known as cardinals. The use of the title was reserved for the cardinals of Rome in 1567 by Pius V.. Answer: {'text': [], 'answer_start': []}. Question: |
In what year did Pope Pius IV wrote abou tthe selecting of cardinals? | Context: In the year 1563 the influential Ecumenical Council of Trent, headed by Pope Pius IV, wrote about the importance of selecting good Cardinals. According to this historic council "nothing is more necessary to the Church of God than that the holy Roman pontiff apply that solicitude which by the duty of his office he owes the universal Church in a very special way by associating with himself as cardinals the most select persons only, and appoint to each church most eminently upright and competent shepherds; and this the more so, because our Lord Jesus Christ will require at his hands the blood of the sheep of Christ that perish through the evil government of shepherds who are negligent and forgetful of their office.". Answer: {'text': ['1563'], 'answer_start': [12]}. Question: |
Who was in charge of the Ecumenical Council of Trent? | Context: In the year 1563 the influential Ecumenical Council of Trent, headed by Pope Pius IV, wrote about the importance of selecting good Cardinals. According to this historic council "nothing is more necessary to the Church of God than that the holy Roman pontiff apply that solicitude which by the duty of his office he owes the universal Church in a very special way by associating with himself as cardinals the most select persons only, and appoint to each church most eminently upright and competent shepherds; and this the more so, because our Lord Jesus Christ will require at his hands the blood of the sheep of Christ that perish through the evil government of shepherds who are negligent and forgetful of their office.". Answer: {'text': ['Pope Pius IV'], 'answer_start': [72]}. Question: |
In what year did the Ecumenical Council of Trent write in regards to the selection of Cardinals? | Context: In the year 1563 the influential Ecumenical Council of Trent, headed by Pope Pius IV, wrote about the importance of selecting good Cardinals. According to this historic council "nothing is more necessary to the Church of God than that the holy Roman pontiff apply that solicitude which by the duty of his office he owes the universal Church in a very special way by associating with himself as cardinals the most select persons only, and appoint to each church most eminently upright and competent shepherds; and this the more so, because our Lord Jesus Christ will require at his hands the blood of the sheep of Christ that perish through the evil government of shepherds who are negligent and forgetful of their office.". Answer: {'text': ['1563'], 'answer_start': [12]}. Question: |
Who was the pope who headed the Ecumencial Council of Trent in that year? | Context: In the year 1563 the influential Ecumenical Council of Trent, headed by Pope Pius IV, wrote about the importance of selecting good Cardinals. According to this historic council "nothing is more necessary to the Church of God than that the holy Roman pontiff apply that solicitude which by the duty of his office he owes the universal Church in a very special way by associating with himself as cardinals the most select persons only, and appoint to each church most eminently upright and competent shepherds; and this the more so, because our Lord Jesus Christ will require at his hands the blood of the sheep of Christ that perish through the evil government of shepherds who are negligent and forgetful of their office.". Answer: {'text': ['Pope Pius IV'], 'answer_start': [72]}. Question: |
What year did the Ecumenical Council of Trent headed by Pope Zacharius write about the importance of selecting good cardinals? | Context: In the year 1563 the influential Ecumenical Council of Trent, headed by Pope Pius IV, wrote about the importance of selecting good Cardinals. According to this historic council "nothing is more necessary to the Church of God than that the holy Roman pontiff apply that solicitude which by the duty of his office he owes the universal Church in a very special way by associating with himself as cardinals the most select persons only, and appoint to each church most eminently upright and competent shepherds; and this the more so, because our Lord Jesus Christ will require at his hands the blood of the sheep of Christ that perish through the evil government of shepherds who are negligent and forgetful of their office.". Answer: {'text': [], 'answer_start': []}. Question: |
Who led the Ecumenical Council of Thames? | Context: In the year 1563 the influential Ecumenical Council of Trent, headed by Pope Pius IV, wrote about the importance of selecting good Cardinals. According to this historic council "nothing is more necessary to the Church of God than that the holy Roman pontiff apply that solicitude which by the duty of his office he owes the universal Church in a very special way by associating with himself as cardinals the most select persons only, and appoint to each church most eminently upright and competent shepherds; and this the more so, because our Lord Jesus Christ will require at his hands the blood of the sheep of Christ that perish through the evil government of shepherds who are negligent and forgetful of their office.". Answer: {'text': [], 'answer_start': []}. Question: |
Who did the historic council determine that the College of Cardinals should select as cardinals? | Context: In the year 1563 the influential Ecumenical Council of Trent, headed by Pope Pius IV, wrote about the importance of selecting good Cardinals. According to this historic council "nothing is more necessary to the Church of God than that the holy Roman pontiff apply that solicitude which by the duty of his office he owes the universal Church in a very special way by associating with himself as cardinals the most select persons only, and appoint to each church most eminently upright and competent shepherds; and this the more so, because our Lord Jesus Christ will require at his hands the blood of the sheep of Christ that perish through the evil government of shepherds who are negligent and forgetful of their office.". Answer: {'text': [], 'answer_start': []}. Question: |
What did our Lord Jesus Christ not require according to the Council of Trent? | Context: In the year 1563 the influential Ecumenical Council of Trent, headed by Pope Pius IV, wrote about the importance of selecting good Cardinals. According to this historic council "nothing is more necessary to the Church of God than that the holy Roman pontiff apply that solicitude which by the duty of his office he owes the universal Church in a very special way by associating with himself as cardinals the most select persons only, and appoint to each church most eminently upright and competent shepherds; and this the more so, because our Lord Jesus Christ will require at his hands the blood of the sheep of Christ that perish through the evil government of shepherds who are negligent and forgetful of their office.". Answer: {'text': [], 'answer_start': []}. Question: |
Who would not be negligent or forgetful of their office? | Context: In the year 1563 the influential Ecumenical Council of Trent, headed by Pope Pius IV, wrote about the importance of selecting good Cardinals. According to this historic council "nothing is more necessary to the Church of God than that the holy Roman pontiff apply that solicitude which by the duty of his office he owes the universal Church in a very special way by associating with himself as cardinals the most select persons only, and appoint to each church most eminently upright and competent shepherds; and this the more so, because our Lord Jesus Christ will require at his hands the blood of the sheep of Christ that perish through the evil government of shepherds who are negligent and forgetful of their office.". Answer: {'text': [], 'answer_start': []}. Question: |
Who were generally temporal rulers? | Context: The earlier influence of temporal rulers, notably the French kings, reasserted itself through the influence of cardinals of certain nationalities or politically significant movements. Traditions even developed entitling certain monarchs, including those of Austria, Spain, and Portugal, to nominate one of their trusted clerical subjects to be created cardinal, a so-called crown-cardinal.[citation needed]. Answer: {'text': ['French kings'], 'answer_start': [54]}. Question: |
Who reasserted the earliest influence of temporal subjects? | Context: The earlier influence of temporal rulers, notably the French kings, reasserted itself through the influence of cardinals of certain nationalities or politically significant movements. Traditions even developed entitling certain monarchs, including those of Austria, Spain, and Portugal, to nominate one of their trusted clerical subjects to be created cardinal, a so-called crown-cardinal.[citation needed]. Answer: {'text': [], 'answer_start': []}. Question: |
Who did the English kings appoint to influence politically significant movement? | Context: The earlier influence of temporal rulers, notably the French kings, reasserted itself through the influence of cardinals of certain nationalities or politically significant movements. Traditions even developed entitling certain monarchs, including those of Austria, Spain, and Portugal, to nominate one of their trusted clerical subjects to be created cardinal, a so-called crown-cardinal.[citation needed]. Answer: {'text': [], 'answer_start': []}. Question: |
What tradition in England, France, and Portugal developed entitling certain political influencers to nominate their trusted subjects? | Context: The earlier influence of temporal rulers, notably the French kings, reasserted itself through the influence of cardinals of certain nationalities or politically significant movements. Traditions even developed entitling certain monarchs, including those of Austria, Spain, and Portugal, to nominate one of their trusted clerical subjects to be created cardinal, a so-called crown-cardinal.[citation needed]. Answer: {'text': [], 'answer_start': []}. Question: |
Who did not reassert themselves through the influence of cardinals? | Context: The earlier influence of temporal rulers, notably the French kings, reasserted itself through the influence of cardinals of certain nationalities or politically significant movements. Traditions even developed entitling certain monarchs, including those of Austria, Spain, and Portugal, to nominate one of their trusted clerical subjects to be created cardinal, a so-called crown-cardinal.[citation needed]. Answer: {'text': [], 'answer_start': []}. Question: |
In what roles did cardinals have important roles? | Context: In early modern times, cardinals often had important roles in secular affairs. In some cases, they took on powerful positions in government. In Henry VIII's England, his chief minister was Cardinal Wolsey. Cardinal Richelieu's power was so great that he was for many years effectively the ruler of France. Richelieu successor was also a cardinal, Jules Mazarin. Guillaume Dubois and André-Hercule de Fleury complete the list of the "four great" cardinals to have ruled France.[citation needed] In Portugal, due to a succession crisis, one cardinal, Henry, King of Portugal, was crowned king, the only example of a cardinal-king.. Answer: {'text': ['secular affairs.'], 'answer_start': [62]}. Question: |
What Caridinal had powers so great that he basically ran France? | Context: In early modern times, cardinals often had important roles in secular affairs. In some cases, they took on powerful positions in government. In Henry VIII's England, his chief minister was Cardinal Wolsey. Cardinal Richelieu's power was so great that he was for many years effectively the ruler of France. Richelieu successor was also a cardinal, Jules Mazarin. Guillaume Dubois and André-Hercule de Fleury complete the list of the "four great" cardinals to have ruled France.[citation needed] In Portugal, due to a succession crisis, one cardinal, Henry, King of Portugal, was crowned king, the only example of a cardinal-king.. Answer: {'text': ['Cardinal Richelieu'], 'answer_start': [206]}. Question: |
Which cardinal acted a the leader of France due to his amount of power? | Context: In early modern times, cardinals often had important roles in secular affairs. In some cases, they took on powerful positions in government. In Henry VIII's England, his chief minister was Cardinal Wolsey. Cardinal Richelieu's power was so great that he was for many years effectively the ruler of France. Richelieu successor was also a cardinal, Jules Mazarin. Guillaume Dubois and André-Hercule de Fleury complete the list of the "four great" cardinals to have ruled France.[citation needed] In Portugal, due to a succession crisis, one cardinal, Henry, King of Portugal, was crowned king, the only example of a cardinal-king.. Answer: {'text': ['Cardinal Richelieu'], 'answer_start': [206]}. Question: |
Who is the only person to ever become a cardinal king? | Context: In early modern times, cardinals often had important roles in secular affairs. In some cases, they took on powerful positions in government. In Henry VIII's England, his chief minister was Cardinal Wolsey. Cardinal Richelieu's power was so great that he was for many years effectively the ruler of France. Richelieu successor was also a cardinal, Jules Mazarin. Guillaume Dubois and André-Hercule de Fleury complete the list of the "four great" cardinals to have ruled France.[citation needed] In Portugal, due to a succession crisis, one cardinal, Henry, King of Portugal, was crowned king, the only example of a cardinal-king.. Answer: {'text': ['Henry, King of Portugal'], 'answer_start': [549]}. Question: |
What role did priests have in secular affairs? | Context: In early modern times, cardinals often had important roles in secular affairs. In some cases, they took on powerful positions in government. In Henry VIII's England, his chief minister was Cardinal Wolsey. Cardinal Richelieu's power was so great that he was for many years effectively the ruler of France. Richelieu successor was also a cardinal, Jules Mazarin. Guillaume Dubois and André-Hercule de Fleury complete the list of the "four great" cardinals to have ruled France.[citation needed] In Portugal, due to a succession crisis, one cardinal, Henry, King of Portugal, was crowned king, the only example of a cardinal-king.. Answer: {'text': [], 'answer_start': []}. Question: |
Who did not take powerful positions in government? | Context: In early modern times, cardinals often had important roles in secular affairs. In some cases, they took on powerful positions in government. In Henry VIII's England, his chief minister was Cardinal Wolsey. Cardinal Richelieu's power was so great that he was for many years effectively the ruler of France. Richelieu successor was also a cardinal, Jules Mazarin. Guillaume Dubois and André-Hercule de Fleury complete the list of the "four great" cardinals to have ruled France.[citation needed] In Portugal, due to a succession crisis, one cardinal, Henry, King of Portugal, was crowned king, the only example of a cardinal-king.. Answer: {'text': [], 'answer_start': []}. Question: |
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