id stringlengths 1 3 | document_id stringlengths 5 8 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
0 | 10026165 | [
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"3,4-Dihydroxyphenylalanine (Dopa) decarboxylase is a stereospecific pyridoxal 5'-phosphate (PLP)-dependent alpha-decarboxylase that converts L-aromatic amino acids into their corresponding amines. We now report that reaction of the enzyme with D-5-hydroxytrypto... | [
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2 | 10027587 | [
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"Extracts of the creosote bush (Larrea tridentata, family Zygophyllaceae) have long been used as a folk remedy for Type II (non-insulin-dependent) diabetes by native Americans in southwestern North America. In this study we have evaluated the metabolic effects of... | [
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"Larrea tride... | [] | [] | [
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"arg1_id": "3_T4"... |
4 | 10027798 | [
{
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"Recently, it was shown that diclofenac was metabolized in rats to reactive benzoquinone imines via cytochrome P450-catalyzed oxidation. These metabolites also were detected in human hepatocyte cultures in the form of glutathione (GSH) adducts. This report descr... | [
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"diclofenac"
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"rats"
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... | [] | [] | [
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6 | 10027801 | [
{
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"text": [
"Cytochrome P450 2C11 in rats was recently found to metabolize diclofenac into a highly reactive product that covalently bound to this enzyme before it could diffuse away and react with other proteins. To determine whether cytochromes P450 in human liver could ca... | [
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"rats"
... | [] | [] | [
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"type": "Binds_With",
"arg1_id": "7_... |
8 | 10027870 | [
{
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"text": [
"The marked analgesic efficacy of ketorolac in humans, relative to other nonsteroidal anti-inflammatory drugs (NSAIDs), has lead to speculation as to whether additional non-NSAID mechanism(s) contribute to its analgesic actions. To evaluate this possibility, we c... | [
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"analgesic"
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"ket... | [] | [] | [
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"arg1_id": ... |
10 | 10027962 | [
{
"id": "11",
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"text": [
"Diazaborine and isoniazid are, at first sight, unrelated anti-bacterial agents that inhibit the enoyl-ACP reductase (ENR) of Escherichia coli and Mycobacterium tuberculosis respectively. The crystal structures of these enzymes including that of the diazaborine... | [
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"isoniazid"
... | [] | [] | [
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12 | 10028198 | [
{
"id": "13",
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"text": [
"The aim of this study was to investigate the distribution, excretion and metabolism of 1,2-dimethylnaphthalene-[ring-U-3H] in rats. The experiments were performed on 54 male outbred IMP:Wist rats with body weight of 200 g +/- 20%. The compound was given i.p. in... | [
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"1,2-dimethylnaphthalene"
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... | [] | [] | [
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14 | 10028199 | [
{
"id": "15",
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"text": [
"Trimethylbenzene isomers (TMBs): 1,2,4-TMB (pseudocumene--PS), 1,2,3-TMB (hemimellitene--HM) and 1,3,5-TMB (mesitylene--MES) are important constituents of solvent mixtures. In the US, the adopted TLV-TWA value for TMBs is 125 mg/m3 or 25 ppm (ACGIH 1996). Recen... | [
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0,
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26,
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"text": [
"TMBs"
... | [] | [] | [] |
16 | 10029225 | [
{
"id": "17",
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"text": [
"OBJECTIVE: To examine exposure-response relationships in the occurrence of symptoms of the eyes and airways in workers exposed to methyltetrahydrophthalic anhydride (MTHPA). METHODS: A population of 111 workers from 2 condenser plants (A and B) using epoxy resi... | [
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130,
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"methyltetrahydrophthalic anhydride"
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... | [] | [] | [] |
18 | 1002932 | [
{
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"type": "",
"text": [
"\n"
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"offsets": [
[
0,
1
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] | [] | [] | [] | [] |
20 | 10030438 | [
{
"id": "21",
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"text": [
"All the benzodiazepines (BZDs) in clinical use have the capacity to promote the binding of the major inhibitory neurotransmitter, gamma-amino-butyric acid (GABA), to sub-types of GABA receptors which exist as multi-subunit ligand-gated chloride channels. Thus,... | [
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"gamma... | [] | [] | [
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"a... |
22 | 1003703 | [
{
"id": "23",
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"text": [
"Anti-ulcer effects of cetraxate, a new compound possessing anti-plasmin, anti-casein and anti-trypsin actions were investigated by using experimental gastric ulcer models in rats. Cetraxate, 300 mg/kg p.o. showed significant inhibitory effects of 65.3%, 70.0%, ... | [
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"c... | [] | [] | [
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24 | 10037325 | [
{
"id": "25",
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"text": [
"The induction of micronucleated erythrocytes by diisopropylcarbodiimide (DIC) and dicyclohexylcarbodiimide (DCC) was investigated as part of a U.S. National Toxicology Program (NTP) evaluation of the subchronic toxicity of these chemicals. Analysis of periphera... | [
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... | [] | [] | [
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... |
26 | 10037456 | [
{
"id": "27",
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"text": [
"We investigated the protective effect of fluvastatin sodium on the oxidation of low-density lipoprotein (LDL) induced in vitro by copper ions. The extent of lipid peroxidation was assessed by monitoring the increase of UV absorbance at 234 nm, which is the peak... | [
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... |
28 | 10048024 | [
{
"id": "29",
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"text": [
"Sequence analysis reveals that the Bacillus subtilis 168 tuaABCDEFGH operon encodes enzymes required for the polymerization of teichuronic acid as well as for the synthesis of one of its precursors, the UDP-glucuronate. Mutants deficient in any of the tua genes... | [
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... | [] | [] | [
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30 | 10048138 | [
{
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"text": [
"Oxaliplatin (4 mg/kg), cisplatin (2 mg/kg with 20 mg/kg mannitol) and ormaplatin (2 mg/kg) were administered i.p. twice weekly for 4.5 weeks. Lactose injections (0.9%) were used as a control for oxaliplatin and 0.9% saline injections were used as a control for... | [
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"cisplatin"
... | [] | [] | [
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... |
32 | 10048141 | [
{
"id": "33",
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"text": [
"1,2-Dichlorobenzene (1,2-DCB) is a potent hepatotoxicant in male Fischer 344 (F344) rats and previous studies have suggested that reactive oxygen species may play a role in the development of hepatotoxicity. Since reactive oxygen species can damage lipid membr... | [
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"1,2... | [] | [] | [
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34 | 10048179 | [
{
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"text": [
"The crystal structure of gliclazide, N-[(perhydrocyclopenta [c]pyrrol-2-yl)aminocarbonyl]-p-toluenesulfonamide, C15H21B3O3S, a second-generation oral hypoglycemic agent, contains discrete molecules with normal molecular dimensions. Both of the five-membered fus... | [
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37,
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"text": [
"N-[(perhyd... | [] | [] | [
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36 | 10048567 | [
{
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"text": [
"Antibacterial antibiotics, diperamycin (1) was produced in the culture broth of Streptomyces griseoaurantiacus MK393-AF2. Various spectroscopic analyses of 1 suggested that 1 belonged to a member of cyclic hexadepsipeptide antibiotic. Antibiotic 1 had potent in... | [
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38 | 10048572 | [
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"text": [
"\n"
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40 | 10048707 | [
{
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"By assaying lactate dehydrogenase and malondialdehyde leakage from LLC-PK1 cells in culture, a study was conducted to clarify whether flavonoid compounds ameliorate renal cellular injury. The cells were cultured with various concentrations of samples under rou... | [
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42 | 100496 | [
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"\n"
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44 | 10049714 | [
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"text": [
"Dopamine D4-like binding sites are abundant in human cerebral cortex as detected by [3H]nemonapride. The extremely low density of D4 mRNA in human cerebral cortex is inconsistent with the high amount of D4-like binding sites. To investigate the nature of the D... | [
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46 | 10052027 | [
{
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"text": [
"The concentrations of adrenaline, noradrenaline, dopamine, aldosterone, the atrial natriuretic hormone, and plasma renin activity were investigated in 50 patients with mild chronic heart failure. The patients received oral digoxin chronically in a daily dose of... | [
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{
"id": "47_R3",
"type": "Isolated_From",
"arg1_id"... |
48 | 10052973 | [
{
"id": "49",
"type": "",
"text": [
"Three series of cycloalkanecarboxylic esters derived from the naturally occurring clavine alkaloids lysergol, dihydrolysergol-I, and elymoclavine were synthesized to study their interaction with 5-HT2A receptors and alpha1-adrenoceptors in rat tail artery and... | [
{
"id": "49_T1",
"type": "Chemical",
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100,
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],
[
110,
127
],
[
133,
145
],
[
16,
44
]
],
"text": [
"lysergol",
"dihydrolysergol-I",
"elymoclavine",
... | [] | [] | [
{
"id": "49_R1",
"type": "Associated_With",
"arg1_id": "49_T23",
"arg2_id": "49_T20",
"normalized": []
},
{
"id": "49_R16",
"type": "Associated_With",
"arg1_id": "49_T81",
"arg2_id": "49_T95",
"normalized": []
},
{
"id": "49_R17",
"type": "Associated_With",
... |
50 | 100603 | [
{
"id": "51",
"type": "",
"text": [
"Subcutaneous tumor induction with three dose levels of 3-methylcholanthrene (MCA), benzo[a]pyrene (BP), and 7,12-dimethylbenz[a]anthracene (DMBA) in two vehicles was studied in C3H/Anf Cum, C57BL/6 Cum, DBA/2J, and (C57BLXC3H/Anf)F1 (BC3F1/Cum) mice. Median tum... | [
{
"id": "51_T2",
"type": "Chemical",
"offsets": [
[
55,
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]
],
"text": [
"3-methylcholanthrene"
],
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},
{
"id": "51_T3",
"type": "Chemical",
"offsets": [
[
77,
80
]
],
"text": [
"M... | [] | [] | [
{
"id": "51_R1",
"type": "Associated_With",
"arg1_id": "51_T2",
"arg2_id": "51_T10",
"normalized": []
},
{
"id": "51_R2",
"type": "Associated_With",
"arg1_id": "51_T3",
"arg2_id": "51_T10",
"normalized": []
},
{
"id": "51_R3",
"type": "Associated_With",
"a... |
52 | 10064158 | [
{
"id": "53",
"type": "",
"text": [
"Exposure of Clone 9 cells, a nontransformed rat liver cell line expressing only the Glutl glucose transporter isoform, to the guanylyl cyclase inhibitor LY-83583 was found to stimulate the rate of glucose transport (approximately 7- to 8-fold in 1 h). A simila... | [
{
"id": "53_T1",
"type": "Protein",
"offsets": [
[
84,
109
]
],
"text": [
"Glutl glucose transporter"
],
"normalized": []
},
{
"id": "53_T2",
"type": "Biological_Activity",
"offsets": [
[
143,
152
]
],
... | [] | [] | [
{
"id": "53_R1",
"type": "Associated_With",
"arg1_id": "53_T5",
"arg2_id": "53_T2",
"normalized": []
},
{
"id": "53_R2",
"type": "Associated_With",
"arg1_id": "53_T5",
"arg2_id": "53_T6",
"normalized": []
},
{
"id": "53_R3",
"type": "Associated_With",
"arg... |
54 | 10064560 | [
{
"id": "55",
"type": "",
"text": [
"Retinaldehyde (RAL), a key intermediate in retinoid metabolism, acts as a retinoic acid (RA) precursor, but is also reduced to retinol (ROH), which can subsequently be esterified to retinyl esters, the storage form of vitamin A. Limited information is available... | [
{
"id": "55_T1",
"type": "Metabolite",
"offsets": [
[
0,
13
]
],
"text": [
"Retinaldehyde"
],
"normalized": []
},
{
"id": "55_T2",
"type": "Chemical",
"offsets": [
[
0,
13
]
],
"text": [
"Retinald... | [] | [] | [
{
"id": "55_R1",
"type": "Metabolite_Of",
"arg1_id": "55_T7",
"arg2_id": "55_T2",
"normalized": []
},
{
"id": "55_R2",
"type": "Metabolite_Of",
"arg1_id": "55_T11",
"arg2_id": "55_T2",
"normalized": []
},
{
"id": "55_R3",
"type": "Metabolite_Of",
"arg1_id"... |
56 | 10066805 | [
{
"id": "57",
"type": "",
"text": [
"UDP-glucose: anthocyanin 5-O-glucosyltransferase (5-GT) is responsible for the modification of anthocyanins to more stable molecules in complexes for co-pigmentation, supposedly resulting in a purple hue. The cDNA encoding 5-GT was isolated by a differential di... | [
{
"id": "57_T1",
"type": "Protein",
"offsets": [
[
0,
48
]
],
"text": [
"UDP-glucose: anthocyanin 5-O-glucosyltransferase"
],
"normalized": []
},
{
"id": "57_T4",
"type": "Protein",
"offsets": [
[
50,
54
]
... | [] | [] | [
{
"id": "57_R1",
"type": "Associated_With",
"arg1_id": "57_T24",
"arg2_id": "57_T35",
"normalized": []
},
{
"id": "57_R2",
"type": "Metabolite_Of",
"arg1_id": "57_T23",
"arg2_id": "57_T21",
"normalized": []
},
{
"id": "57_R3",
"type": "Isolated_From",
"arg... |
58 | 10069359 | [
{
"id": "59",
"type": "",
"text": [
"The cephalosporins are a large group of related beta-lactam antimicrobial agents. Favorable attributes of the cephalosporins include low rates of toxicity, relatively broad spectrum of activity, and ease of administration. Various cephalosporins are effective f... | [
{
"id": "59_T1",
"type": "Chemical",
"offsets": [
[
4,
18
]
],
"text": [
"cephalosporins"
],
"normalized": []
},
{
"id": "59_T2",
"type": "Chemical",
"offsets": [
[
48,
59
]
],
"text": [
"beta-lac... | [] | [] | [
{
"id": "59_R1",
"type": "Associated_With",
"arg1_id": "59_T1",
"arg2_id": "59_T3",
"normalized": []
},
{
"id": "59_R3",
"type": "Associated_With",
"arg1_id": "59_T8",
"arg2_id": "59_T9",
"normalized": []
},
{
"id": "59_R4",
"type": "Associated_With",
"arg... |
60 | 10069454 | [
{
"id": "61",
"type": "",
"text": [
"DNA-dependent protein kinase (DNA-PK) and poly(ADP-ribose) polymerase (PARP) are activated by DNA strand breaks and participate in DNA repair. We investigated the interactive effects of inhibitors of these enzymes [wortmannin (WM), which inhibits DNA-PK, and 8... | [
{
"id": "61_T1",
"type": "Protein",
"offsets": [
[
0,
28
]
],
"text": [
"DNA-dependent protein kinase"
],
"normalized": []
},
{
"id": "61_T2",
"type": "Protein",
"offsets": [
[
30,
36
]
],
"text": [
... | [] | [] | [
{
"id": "61_R1",
"type": "Associated_With",
"arg1_id": "61_T11",
"arg2_id": "61_T13",
"normalized": []
},
{
"id": "61_R2",
"type": "Associated_With",
"arg1_id": "61_T12",
"arg2_id": "61_T13",
"normalized": []
},
{
"id": "61_R3",
"type": "Associated_With",
... |
62 | 10070780 | [
{
"id": "63",
"type": "",
"text": [
"The FM4-64, a member of the family of fluorescent dyes, has been applied to the cerebellar cortex to evaluate its properties as an intracellular stain and intracortical tracer. Slabs of hamster cerebellum, 1-2 mm thick, were incubated in 10, 30, and 100 microns... | [
{
"id": "63_T1",
"type": "Chemical",
"offsets": [
[
4,
10
]
],
"text": [
"FM4-64"
],
"normalized": []
},
{
"id": "63_T4",
"type": "Species",
"offsets": [
[
186,
193
]
],
"text": [
"hamster"
],... | [] | [] | [] |
64 | 10071923 | [
{
"id": "65",
"type": "",
"text": [
"A comparative study of various procedures for tryptophanyl peptide bond cleavage by BNPS-skatole [2-(2-nitrophenyl)-3-methyl-3-bromoindolenine] was carried out on native and on reduced and alkylated bovine beta-lactoglobulin (BLG). The reaction yield and the c... | [
{
"id": "65_T1",
"type": "Chemical",
"offsets": [
[
85,
97
]
],
"text": [
"BNPS-skatole"
],
"normalized": []
},
{
"id": "65_T2",
"type": "Chemical",
"offsets": [
[
99,
143
]
],
"text": [
"2-(2-nit... | [] | [] | [
{
"id": "65_R3",
"type": "Associated_With",
"arg1_id": "65_T20",
"arg2_id": "65_T19",
"normalized": []
},
{
"id": "65_R4",
"type": "Associated_With",
"arg1_id": "65_T22",
"arg2_id": "65_T21",
"normalized": []
}
] |
66 | 10072406 | [
{
"id": "67",
"type": "",
"text": [
"We conducted a study of the patterns and dynamics of oxidized fatty acid derivatives (oxylipins) in potato leaves infected with the late-blight pathogen Phytophthora infestans. Two 18-carbon divinyl ether fatty acids, colneleic acid and colnelenic acid, accumul... | [
{
"id": "67_T1",
"type": "Chemical",
"offsets": [
[
53,
84
]
],
"text": [
"oxidized fatty acid derivatives"
],
"normalized": []
},
{
"id": "67_T2",
"type": "Chemical",
"offsets": [
[
86,
95
]
],
"text":... | [] | [] | [
{
"id": "67_R1",
"type": "Associated_With",
"arg1_id": "67_T24",
"arg2_id": "67_T25",
"normalized": []
},
{
"id": "67_R2",
"type": "Associated_With",
"arg1_id": "67_T23",
"arg2_id": "67_T25",
"normalized": []
},
{
"id": "67_R4",
"type": "Isolated_From",
"a... |
68 | 10073739 | [
{
"id": "69",
"type": "",
"text": [
"AIMS: Cysteamine, the only drug available for the treatment of cystinosis in paediatric patients, is available as the hydrochloride, the bitartrate and as sodium phosphocysteamine salts. It has been suggested that cysteamine bitartrate and phosphocysteamine ar... | [
{
"id": "69_T1",
"type": "Chemical",
"offsets": [
[
118,
131
],
[
137,
147
],
[
6,
16
]
],
"text": [
"hydrochloride",
"bitartrate",
"Cysteamine"
],
"normalized": []
},
{
"id": "6... | [] | [] | [
{
"id": "69_R1",
"type": "Associated_With",
"arg1_id": "69_T20",
"arg2_id": "69_T8",
"normalized": []
},
{
"id": "69_R2",
"type": "Associated_With",
"arg1_id": "69_T21",
"arg2_id": "69_T8",
"normalized": []
},
{
"id": "69_R3",
"type": "Associated_With",
"a... |
70 | 10073910 | [
{
"id": "71",
"type": "",
"text": [
"Tyrosinaemia type I is caused by a deficiency of fumarylacetoacetate hydrolase and mainly affects the liver. This disease is characterized by the presence of a high level of succinylacetone. This metabolite has been used for prenatal diagnosis from amniotic fl... | [
{
"id": "71_T2",
"type": "Protein",
"offsets": [
[
49,
78
]
],
"text": [
"fumarylacetoacetate hydrolase"
],
"normalized": []
},
{
"id": "71_T4",
"type": "Chemical",
"offsets": [
[
175,
190
]
],
"text": ... | [] | [] | [] |
End of preview. Expand in Data Studio
Dataset Card for CHEBI Corpus
The ChEBI corpus contains 199 annotated abstracts and 100 annotated full papers. All documents in the corpus have been annotated for named entities and relations between these. In total, our corpus provides over 15000 named entity annotations and over 6,000 relations between entities.
Citation Information
@inproceedings{Shardlow2018,
title = {
A New Corpus to Support Text Mining for the Curation of Metabolites in the
{ChEBI} Database
},
author = {
Shardlow, M J and Nguyen, N and Owen, G and O'Donovan, C and Leach, A and
McNaught, J and Turner, S and Ananiadou, S
},
year = 2018,
month = may,
booktitle = {
Proceedings of the Eleventh International Conference on Language Resources
and Evaluation ({LREC} 2018)
},
location = {Miyazaki, Japan},
pages = {280--285},
conference = {
Eleventh International Conference on Language Resources and Evaluation
(LREC 2018)
},
language = {en}
}
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