id stringlengths 1 4 | document_id stringlengths 12 13 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
2 | PMID-1419903 | [
{
"id": "PMID-1419903__text",
"type": "abstract",
"text": [
"Regulation of c-jun expression during induction of monocytic differentiation by okadaic acid. \nThe present work has examined the effects of okadaic acid, an inhibitor of type 1 and 2A protein phosphatases, on the regulation of c-jun exp... | [
{
"id": "PMID-1419903_T1",
"type": "Protein",
"text": [
"c-jun"
],
"offsets": [
[
14,
19
]
],
"normalized": []
},
{
"id": "PMID-1419903_T2",
"type": "Protein",
"text": [
"type 1"
],
"offsets": [
[
170,
... | [] | [] | [] |
4 | PMID-10364157 | [
{
"id": "PMID-10364157__text",
"type": "abstract",
"text": [
"Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. \nMalignant transformation usually inhibits terminal cell differentiation but the precise mechanisms involved are not u... | [
{
"id": "PMID-10364157_T1",
"type": "Protein",
"text": [
"PU.1"
],
"offsets": [
[
58,
62
]
],
"normalized": []
},
{
"id": "PMID-10364157_T2",
"type": "Protein",
"text": [
"GATA-1"
],
"offsets": [
[
67,
... | [] | [] | [] |
6 | PMID-9223506 | [
{
"id": "PMID-9223506__text",
"type": "abstract",
"text": [
"Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity. \nWhen transcriptionally active, the human immunodeficiency virus (HIV) promoter conta... | [
{
"id": "PMID-9223506_T1",
"type": "Protein",
"text": [
"Sp1"
],
"offsets": [
[
649,
652
]
],
"normalized": []
},
{
"id": "PMID-9223506_T2",
"type": "Protein",
"text": [
"Sp1"
],
"offsets": [
[
1213,
12... | [] | [] | [] |
9 | PMID-9299590 | [
{
"id": "PMID-9299590__text",
"type": "abstract",
"text": [
"The role of Rel/NF-kappa B proteins in viral oncogenesis and the regulation of viral transcription. \nRel/NF-kappa B is a ubiquitous transcription factor that consists of multiple polypeptide subunits, and is subject to complex regulator... | [] | [] | [] | [] |
10 | PMID-9121455 | [
{
"id": "PMID-9121455__text",
"type": "abstract",
"text": [
"Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain. \nThe nuclear factor of activated T cells (NFAT) regulates cytokine gene expression in T cells through cis-acting elements located in the promoters of ... | [
{
"id": "PMID-9121455_T1",
"type": "Protein",
"text": [
"NFATx1"
],
"offsets": [
[
11,
17
]
],
"normalized": []
},
{
"id": "PMID-9121455_T2",
"type": "Protein",
"text": [
"NFATx1"
],
"offsets": [
[
260,
... | [] | [] | [] |
13 | PMID-10358154 | [
{
"id": "PMID-10358154__text",
"type": "abstract",
"text": [
"New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation. \nWe had previously shown that the drug undecylprodigiosin (UP) blocks human lymphocyte proliferation in vitro. We have now inv... | [
{
"id": "PMID-10358154_T1",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "PMID-10358154_T2",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
742,
7... | [] | [] | [] |
14 | PMID-1618911 | [
{
"id": "PMID-1618911__text",
"type": "abstract",
"text": [
"Heterodimerization and transcriptional activation in vitro by NF-kappa B proteins. \nThe NF-kappa B family of transcription proteins represents multiple DNA binding, rel related polypeptides that contribute to regulation of genes involve... | [
{
"id": "PMID-1618911_T1",
"type": "Protein",
"text": [
"rel"
],
"offsets": [
[
165,
168
]
],
"normalized": []
},
{
"id": "PMID-1618911_T2",
"type": "Protein",
"text": [
"p50"
],
"offsets": [
[
964,
967... | [] | [] | [] |
19 | PMID-9862666 | [
{
"id": "PMID-9862666__text",
"type": "abstract",
"text": [
"Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP. \nIL-2 gene transcription in T cells requires both TCR and costimulatory signals. IL-2 promoter acti... | [
{
"id": "PMID-9862666_T1",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
66,
70
]
],
"normalized": []
},
{
"id": "PMID-9862666_T2",
"type": "Protein",
"text": [
"CD28"
],
"offsets": [
[
108,
112... | [] | [] | [] |
22 | PMID-8929546 | [
{
"id": "PMID-8929546__text",
"type": "abstract",
"text": [
"Regulation of cytokine and cytokine receptor expression by glucocorticoids. \nGlucocorticoids (GCS) profoundly inhibit several aspects of T cell immunity largely through inhibition of cytokine expression at the transcriptional and posttr... | [
{
"id": "PMID-8929546_T1",
"type": "Protein",
"text": [
"transforming growth factor-beta"
],
"offsets": [
[
311,
342
]
],
"normalized": []
}
] | [] | [] | [] |
23 | PMID-10225377 | [
{
"id": "PMID-10225377__text",
"type": "abstract",
"text": [
"Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. \nIn monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phos... | [
{
"id": "PMID-10225377_T1",
"type": "Protein",
"text": [
"interleukin-1beta"
],
"offsets": [
[
690,
707
]
],
"normalized": []
},
{
"id": "PMID-10225377_T2",
"type": "Protein",
"text": [
"interleukin-1beta"
],
"offsets": [
... | [] | [] | [] |
32 | PMID-9252117 | [
{
"id": "PMID-9252117__text",
"type": "abstract",
"text": [
"EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. \nEarly B cell factor (EBF) and E47 participate in the transcriptional control of early B lymphocyte differentiation. With the aim... | [
{
"id": "PMID-9252117_T1",
"type": "Protein",
"text": [
"EBF"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "PMID-9252117_T2",
"type": "Protein",
"text": [
"E47"
],
"offsets": [
[
8,
11
... | [] | [] | [] |
35 | PMID-8428966 | [
{
"id": "PMID-8428966__text",
"type": "abstract",
"text": [
"Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. \nThe lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cell... | [
{
"id": "PMID-8428966_T1",
"type": "Protein",
"text": [
"Fra-1"
],
"offsets": [
[
900,
905
]
],
"normalized": []
},
{
"id": "PMID-8428966_T2",
"type": "Protein",
"text": [
"cJun"
],
"offsets": [
[
1083,
... | [] | [] | [] |
40 | PMID-7892566 | [
{
"id": "PMID-7892566__text",
"type": "abstract",
"text": [
"[Regulation of transcription of the interleukin-2 gene in B-lymphocytes] \nSince most B cell clones immortalized with EBV virus can be induced to produce interleukin-2, a typical T cell cytokine, we studied the role of different elements... | [
{
"id": "PMID-7892566_T1",
"type": "Protein",
"text": [
"interleukin-2"
],
"offsets": [
[
36,
49
]
],
"normalized": []
},
{
"id": "PMID-7892566_T2",
"type": "Protein",
"text": [
"interleukin-2"
],
"offsets": [
[
... | [] | [] | [] |
42 | PMID-8977228 | [
{
"id": "PMID-8977228__text",
"type": "abstract",
"text": [
"The state of maturation of monocytes into macrophages determines the effects of IL-4 and IL-13 on HIV replication. \nThe molecular mechanisms of the effects of IL-4 and IL-13 on HIV infection in human monocytes as they matured into monoc... | [
{
"id": "PMID-8977228_T1",
"type": "Protein",
"text": [
"IL-4"
],
"offsets": [
[
80,
84
]
],
"normalized": []
},
{
"id": "PMID-8977228_T2",
"type": "Protein",
"text": [
"IL-13"
],
"offsets": [
[
89,
94
... | [] | [] | [] |
49 | PMID-9317151 | [
{
"id": "PMID-9317151__text",
"type": "abstract",
"text": [
"Dual effects of LPS antibodies on cellular uptake of LPS and LPS-induced proinflammatory functions. \nHuman phagocytes recognize bacterial LPS (endotoxin) through membrane CD14 (mCD14), a proinflammatory LPS receptor. This study tested t... | [
{
"id": "PMID-9317151_T1",
"type": "Protein",
"text": [
"CD14"
],
"offsets": [
[
171,
175
]
],
"normalized": []
},
{
"id": "PMID-9317151_T2",
"type": "Protein",
"text": [
"mCD14"
],
"offsets": [
[
177,
... | [] | [] | [] |
50 | PMID-9712026 | [
{
"id": "PMID-9712026__text",
"type": "abstract",
"text": [
"A CD28-associated signaling pathway leading to cytokine gene transcription and T cell proliferation without TCR engagement. \nStimulation of resting human T cells with the CD28-specific mAb BW 828 induces proliferation and cytokine synth... | [
{
"id": "PMID-9712026_T1",
"type": "Protein",
"text": [
"CD28"
],
"offsets": [
[
2,
6
]
],
"normalized": []
},
{
"id": "PMID-9712026_T2",
"type": "Protein",
"text": [
"CD28"
],
"offsets": [
[
171,
175
... | [] | [] | [] |
51 | PMID-8158122 | [
{
"id": "PMID-8158122__text",
"type": "abstract",
"text": [
"Activation of nuclear factor kappa B in human neuroblastoma cell lines. \nThe nuclear factor kappa B (NF-kappa B) is a eukaryotic transcription factor. In B cells and macrophages it is constitutively present in cell nuclei, whereas in ma... | [
{
"id": "PMID-8158122_T1",
"type": "Protein",
"text": [
"tumor necrosis factor alpha"
],
"offsets": [
[
336,
363
]
],
"normalized": []
},
{
"id": "PMID-8158122_T2",
"type": "Protein",
"text": [
"TNF alpha"
],
"offsets": [
... | [] | [] | [] |
53 | PMID-8663022 | [
{
"id": "PMID-8663022__text",
"type": "abstract",
"text": [
"Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter. \nPU.1 (spi-1), a member of the Ets transcription factor family, is predominantly expressed in myeloid and B cells, activates many B cell and my... | [
{
"id": "PMID-8663022_T1",
"type": "Protein",
"text": [
"PU.1"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "PMID-8663022_T2",
"type": "Protein",
"text": [
"spi-1"
],
"offsets": [
[
76,
81
... | [] | [] | [] |
63 | PMID-9136080 | [
{
"id": "PMID-9136080__text",
"type": "abstract",
"text": [
"Structure and function analysis of the human myeloid cell nuclear differentiation antigen promoter: evidence for the role of Sp1 and not of c-Myb or PU.1 in myelomonocytic lineage-specific expression. \nThe human myeloid nuclear differen... | [
{
"id": "PMID-9136080_T1",
"type": "Protein",
"text": [
"myeloid cell nuclear differentiation antigen"
],
"offsets": [
[
45,
89
]
],
"normalized": []
},
{
"id": "PMID-9136080_T2",
"type": "Protein",
"text": [
"Sp1"
],
"offse... | [] | [] | [] |
69 | PMID-9416887 | [
{
"id": "PMID-9416887__text",
"type": "abstract",
"text": [
"Cyclosporin A inhibits monocyte tissue factor activation in cardiac transplant recipients. \nBACKGROUND: Fibrin deposition and thrombosis have been implicated in both allograft rejection and vasculopathy after cardiac transplantation. Be... | [
{
"id": "PMID-9416887_T1",
"type": "Protein",
"text": [
"tissue factor"
],
"offsets": [
[
32,
45
]
],
"normalized": []
},
{
"id": "PMID-9416887_T2",
"type": "Protein",
"text": [
"tissue factor"
],
"offsets": [
[
... | [] | [] | [] |
71 | PMID-9018153 | [
{
"id": "PMID-9018153__text",
"type": "abstract",
"text": [
"Interaction of transcription factors RFX1 and MIBP1 with the gamma motif of the negative regulatory element of the hepatitis B virus core promoter. \nThe negative regulatory element (NRE) of the hepatitis B virus (HBV) core promoter cont... | [
{
"id": "PMID-9018153_T1",
"type": "Protein",
"text": [
"RFX1"
],
"offsets": [
[
37,
41
]
],
"normalized": []
},
{
"id": "PMID-9018153_T2",
"type": "Protein",
"text": [
"MIBP1"
],
"offsets": [
[
46,
51
... | [] | [] | [] |
73 | PMID-9119025 | [
{
"id": "PMID-9119025__text",
"type": "abstract",
"text": [
"Cell-to-cell contact activates the long terminal repeat of human immunodeficiency virus 1 through its kappaB motif. \nCell-to-cell contact between peripheral blood lymphocytes and transfected human colonic carcinoma cell line HT29 activa... | [
{
"id": "PMID-9119025_T1",
"type": "Protein",
"text": [
"p50"
],
"offsets": [
[
770,
773
]
],
"normalized": []
},
{
"id": "PMID-9119025_T2",
"type": "Protein",
"text": [
"p65"
],
"offsets": [
[
774,
777... | [] | [] | [] |
90 | PMID-7859743 | [
{
"id": "PMID-7859743__text",
"type": "abstract",
"text": [
"HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state. \nThis study demonstrates that human immunodeficiency virus type 1 (HIV-1) Tat protein amplifies the activity of tumor necrosi... | [
{
"id": "PMID-7859743_T1",
"type": "Protein",
"text": [
"Tat"
],
"offsets": [
[
6,
9
]
],
"normalized": []
},
{
"id": "PMID-7859743_T2",
"type": "Protein",
"text": [
"Tat"
],
"offsets": [
[
185,
188
... | [] | [] | [] |
93 | PMID-10233927 | [
{
"id": "PMID-10233927__text",
"type": "abstract",
"text": [
"Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus. \nInfection of human B cells with Epstein-Barr virus (EBV) results in activation of the cell cycle and cell growth. To interpret the mechanisms b... | [
{
"id": "PMID-10233927_T1",
"type": "Protein",
"text": [
"cyclin D2"
],
"offsets": [
[
459,
468
]
],
"normalized": []
},
{
"id": "PMID-10233927_T2",
"type": "Protein",
"text": [
"E2F-4"
],
"offsets": [
[
537,
... | [] | [] | [] |
94 | PMID-7659529 | [
{
"id": "PMID-7659529__text",
"type": "abstract",
"text": [
"Regulation of transcription of the human erythropoietin receptor gene by proteins binding to GATA-1 and Sp1 motifs. \nErythropoietin (Epo), the primary regulator of the production of erythroid cells, acts by binding to a cell surface rec... | [
{
"id": "PMID-7659529_T1",
"type": "Protein",
"text": [
"erythropoietin receptor"
],
"offsets": [
[
41,
64
]
],
"normalized": []
},
{
"id": "PMID-7659529_T2",
"type": "Protein",
"text": [
"GATA-1"
],
"offsets": [
[
... | [] | [] | [] |
96 | PMID-8179594 | [
{
"id": "PMID-8179594__text",
"type": "abstract",
"text": [
"Effects of alpha-lipoic acid and dihydrolipoic acid on expression of proto-oncogene c-fos. \nThe transcription factor AP-1 is an important human mediator of the cellular response to serum, growth factors, and phorbol esters such as 12-O-... | [
{
"id": "PMID-8179594_T1",
"type": "Protein",
"text": [
"c-fos"
],
"offsets": [
[
84,
89
]
],
"normalized": []
},
{
"id": "PMID-8179594_T2",
"type": "Protein",
"text": [
"c-fos"
],
"offsets": [
[
365,
3... | [] | [] | [] |
97 | PMID-8562886 | [
{
"id": "PMID-8562886__text",
"type": "abstract",
"text": [
"The effect of Toremifene on the expression of some genes in human mononuclear cells. \nToremifene exerts multiple and varied effects on the gene expression of human peripheral mononuclear cells. After short-term, in vitro exposure to the... | [
{
"id": "PMID-8562886_T1",
"type": "Protein",
"text": [
"p53"
],
"offsets": [
[
310,
313
]
],
"normalized": []
},
{
"id": "PMID-8562886_T2",
"type": "Protein",
"text": [
"Bcl-2"
],
"offsets": [
[
318,
3... | [] | [] | [] |
98 | PMID-8725939 | [
{
"id": "PMID-8725939__text",
"type": "abstract",
"text": [
"Regulation of gene expression at early stages of B-cell and T-cell differentiation. \nThe expression of distinct sets of genes at different stages of B-lymphocyte and T-lymphocyte differentiation is controlled at the level of transcripti... | [] | [] | [] | [] |
99 | PMID-8577772 | [
{
"id": "PMID-8577772__text",
"type": "abstract",
"text": [
"In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors. \nAnergy is a major mechanism to ensure antigen-specific tolerance in T lymphocytes in the adult. In vivo, anergy has mainly been studied at the ... | [
{
"id": "PMID-8577772_T1",
"type": "Protein",
"text": [
"CD4"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "PMID-8577772_T2",
"type": "Protein",
"text": [
"staphylococcal enterotoxin A"
],
"offsets": [
[
... | [] | [] | [] |
103 | PMID-1645452 | [
{
"id": "PMID-1645452__text",
"type": "abstract",
"text": [
"The human myelomonocytic cell line U-937 as a model for studying alterations in steroid-induced monokine gene expression: marked enhancement of lipopolysaccharide-stimulated interleukin-1 beta messenger RNA levels by 1,25-dihydroxyvitami... | [
{
"id": "PMID-1645452_T1",
"type": "Protein",
"text": [
"interleukin-1 beta"
],
"offsets": [
[
174,
192
]
],
"normalized": []
},
{
"id": "PMID-1645452_T2",
"type": "Protein",
"text": [
"interleukin-1 beta"
],
"offsets": [
... | [] | [] | [] |
106 | PMID-10233882 | [
{
"id": "PMID-10233882__text",
"type": "abstract",
"text": [
"An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. \nThe transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in... | [
{
"id": "PMID-10233882_T1",
"type": "Protein",
"text": [
"CD34"
],
"offsets": [
[
41,
45
]
],
"normalized": []
},
{
"id": "PMID-10233882_T2",
"type": "Protein",
"text": [
"CD34"
],
"offsets": [
[
360,
3... | [] | [] | [] |
108 | PMID-8960112 | [
{
"id": "PMID-8960112__text",
"type": "abstract",
"text": [
"Lymphocytes from CML patients lack a 47 kDa factor having affinity for a genomic sterol regulatory sequence. \nDeranged cellular cholesterol homeostasis has been widely recognized in the initiation as well as progression of various types... | [
{
"id": "PMID-8960112_T1",
"type": "Protein",
"text": [
"LDL receptor"
],
"offsets": [
[
842,
854
]
],
"normalized": []
}
] | [] | [] | [] |
111 | PMID-7890658 | [
{
"id": "PMID-7890658__text",
"type": "abstract",
"text": [
"Identification of human TR2 orphan receptor response element in the transcriptional initiation site of the simian virus 40 major late promoter [published erratum appears in J Biol Chem 1995 Nov 3;270(44):26721] \nA DNA response element (... | [
{
"id": "PMID-7890658_T1",
"type": "Protein",
"text": [
"chloramphenicol acetyl-transferase"
],
"offsets": [
[
711,
745
]
],
"normalized": []
}
] | [] | [] | [] |
112 | PMID-8871649 | [
{
"id": "PMID-8871649__text",
"type": "abstract",
"text": [
"A critical role of Sp1- and Ets-related transcription factors in maintaining CTL-specific expression of the mouse perforin gene. \nThis study was designed to determine the potential cis-elements involved in transcriptional regulation of ... | [
{
"id": "PMID-8871649_T1",
"type": "Protein",
"text": [
"Sp1"
],
"offsets": [
[
19,
22
]
],
"normalized": []
},
{
"id": "PMID-8871649_T2",
"type": "Protein",
"text": [
"perforin"
],
"offsets": [
[
114,
... | [] | [] | [] |
113 | PMID-7525701 | [
{
"id": "PMID-7525701__text",
"type": "abstract",
"text": [
"Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B. \nThe B cell-associated surface molecule CD40 functions to regulate B cell responses. Cross-linking CD40 on B cells can lead to homotypic cell adhesion, IL-6 product... | [
{
"id": "PMID-7525701_T1",
"type": "Protein",
"text": [
"CD40"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "PMID-7525701_T2",
"type": "Protein",
"text": [
"CD40"
],
"offsets": [
[
112,
116... | [] | [] | [] |
120 | PMID-2278044 | [
{
"id": "PMID-2278044__text",
"type": "abstract",
"text": [
"Functional analysis of cis-linked regulatory sequences in the HLA DRA promoter by transcription in vitro. \nTwo consensus sequences, called X and Y boxes, capable of binding nuclear proteins and regulating expression in B cells have been... | [
{
"id": "PMID-2278044_T1",
"type": "Protein",
"text": [
"OTF-1"
],
"offsets": [
[
652,
657
]
],
"normalized": []
},
{
"id": "PMID-2278044_T2",
"type": "Protein",
"text": [
"OTF-2"
],
"offsets": [
[
682,
... | [] | [] | [] |
123 | PMID-9765295 | [
{
"id": "PMID-9765295__text",
"type": "abstract",
"text": [
"Fcgamma receptor-mediated mitogen-activated protein kinase activation in monocytes is independent of Ras. \nReceptors for the Fc portion of immunoglobulin molecules (FcR) present on leukocyte cell membranes mediate a large number of cell... | [
{
"id": "PMID-9765295_T1",
"type": "Protein",
"text": [
"Raf-1"
],
"offsets": [
[
1097,
1102
]
],
"normalized": []
}
] | [] | [] | [] |
124 | PMID-1956769 | [
{
"id": "PMID-1956769__text",
"type": "abstract",
"text": [
"Identification of transcriptional suppressor proteins that bind to the negative regulatory element of the human immunodeficiency virus type 1. \nTwo different proteins which independently bound to neighboring sequences within the negativ... | [] | [] | [] | [] |
125 | PMID-7635985 | [
{
"id": "PMID-7635985__text",
"type": "abstract",
"text": [
"Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon-gamma activation site-like sequence upstream of the I epsilon exon in a human B cell line. Evidence for the invo... | [
{
"id": "PMID-7635985_T1",
"type": "Protein",
"text": [
"Interleukin 4"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "PMID-7635985_T2",
"type": "Protein",
"text": [
"interferon-gamma"
],
"offsets": [
[
... | [] | [] | [] |
126 | PMID-9428992 | [
{
"id": "PMID-9428992__text",
"type": "abstract",
"text": [
"Constitutive expression c-fos, c-jun, and NF kappa B mRNA is in nucleated fetal blood cells and up-regulation of c-fos and c-jun with anti-CD3 stimulation. \nFetal and neonatal lymphocytes are relatively resistant to activation and cytok... | [
{
"id": "PMID-9428992_T1",
"type": "Protein",
"text": [
"c-fos"
],
"offsets": [
[
24,
29
]
],
"normalized": []
},
{
"id": "PMID-9428992_T2",
"type": "Protein",
"text": [
"c-jun"
],
"offsets": [
[
31,
36... | [] | [] | [] |
132 | PMID-9725220 | [
{
"id": "PMID-9725220__text",
"type": "abstract",
"text": [
"Transcription of a minimal promoter from the NF-IL6 gene is regulated by CREB/ATF and SP1 proteins in U937 promonocytic cells. \nNF-IL6 is an important transcriptional regulator of genes induced in activated monocytes/macrophages, and NF... | [
{
"id": "PMID-9725220_T1",
"type": "Protein",
"text": [
"NF-IL6"
],
"offsets": [
[
45,
51
]
],
"normalized": []
},
{
"id": "PMID-9725220_T2",
"type": "Protein",
"text": [
"SP1"
],
"offsets": [
[
86,
89
... | [] | [] | [] |
136 | PMID-2105946 | [
{
"id": "PMID-2105946__text",
"type": "abstract",
"text": [
"Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells. \nAP-1, the polypeptide product of c-jun, recognizes and binds to specific DNA sequences and stimul... | [
{
"id": "PMID-2105946_T1",
"type": "Protein",
"text": [
"c-jun"
],
"offsets": [
[
55,
60
]
],
"normalized": []
},
{
"id": "PMID-2105946_T2",
"type": "Protein",
"text": [
"c-jun"
],
"offsets": [
[
172,
1... | [] | [] | [] |
138 | PMID-1907460 | [
{
"id": "PMID-1907460__text",
"type": "abstract",
"text": [
"Inhibition of HIV-1 replication and NF-kappa B activity by cysteine and cysteine derivatives. \nHIV-1 proviral DNA contains two binding sites for the transcription factor NF-kappa B. HIV-1-infected individuals have, on average, abnormall... | [
{
"id": "PMID-1907460_T1",
"type": "Protein",
"text": [
"tumour necrosis factor alpha"
],
"offsets": [
[
253,
281
]
],
"normalized": []
},
{
"id": "PMID-1907460_T2",
"type": "Protein",
"text": [
"TNF alpha"
],
"offsets": [
... | [] | [] | [] |
143 | PMID-9032265 | [
{
"id": "PMID-9032265__text",
"type": "abstract",
"text": [
"Transcriptional regulation of the ferritin heavy-chain gene: the activity of the CCAAT binding factor NF-Y is modulated in heme-treated Friend leukemia cells and during monocyte-to-macrophage differentiation. \nThe ferritin H-chain gene ... | [
{
"id": "PMID-9032265_T1",
"type": "Protein",
"text": [
"ferritin H-chain"
],
"offsets": [
[
214,
230
]
],
"normalized": []
},
{
"id": "PMID-9032265_T2",
"type": "Protein",
"text": [
"ferritin H"
],
"offsets": [
[
... | [] | [] | [] |
144 | PMID-9837745 | [
{
"id": "PMID-9837745__text",
"type": "abstract",
"text": [
"Interleukin-12 expression in B cells by transformation with Epstein-Barr virus. \nAlthough interleukin (IL)-12 was originally purified from an Epstein-Barr (EBV)-transformed B cell line and the high correlation of EBV infection and IL-12... | [
{
"id": "PMID-9837745_T1",
"type": "Protein",
"text": [
"p40"
],
"offsets": [
[
533,
536
]
],
"normalized": []
},
{
"id": "PMID-9837745_T2",
"type": "Protein",
"text": [
"latent membrane protein 1"
],
"offsets": [
[
... | [] | [] | [] |
145 | PMID-7594468 | [
{
"id": "PMID-7594468__text",
"type": "abstract",
"text": [
"Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways. \nThe Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-k... | [
{
"id": "PMID-7594468_T1",
"type": "Protein",
"text": [
"IkB alpha"
],
"offsets": [
[
14,
23
]
],
"normalized": []
},
{
"id": "PMID-7594468_T2",
"type": "Protein",
"text": [
"IkB alpha"
],
"offsets": [
[
660,
... | [] | [] | [] |
146 | PMID-10202024 | [
{
"id": "PMID-10202024__text",
"type": "abstract",
"text": [
"Human cytomegalovirus binding to human monocytes induces immunoregulatory gene expression. \nTo continue our investigation of the cellular events that occur following human CMV (HCMV) infection, we focused on the regulation of cellular ... | [
{
"id": "PMID-10202024_T1",
"type": "Protein",
"text": [
"IL-1beta"
],
"offsets": [
[
370,
378
]
],
"normalized": []
},
{
"id": "PMID-10202024_T2",
"type": "Protein",
"text": [
"A20"
],
"offsets": [
[
380,
... | [] | [] | [] |
147 | PMID-8573121 | [
{
"id": "PMID-8573121__text",
"type": "abstract",
"text": [
"Inhibition of NF-kappa B activation in human T-cell lines by anetholdithiolthione. \nNuclear factor (NF)-kappa B is a redox sensitive cytosolic transcription factor. Redox regulation of NF-kappa B has been implicated in the activation of... | [
{
"id": "PMID-8573121_T1",
"type": "Protein",
"text": [
"tumor necrosis factor alpha"
],
"offsets": [
[
848,
875
]
],
"normalized": []
},
{
"id": "PMID-8573121_T2",
"type": "Protein",
"text": [
"TNF alpha"
],
"offsets": [
... | [] | [] | [] |
148 | PMID-10229841 | [
{
"id": "PMID-10229841__text",
"type": "abstract",
"text": [
"Signaling through the lymphotoxin-beta receptor stimulates HIV-1 replication alone and in cooperation with soluble or membrane-bound TNF-alpha. \nThe level of ongoing HIV-1 replication within an individual is critical to HIV-1 pathogene... | [
{
"id": "PMID-10229841_T1",
"type": "Protein",
"text": [
"lymphotoxin-beta receptor"
],
"offsets": [
[
22,
47
]
],
"normalized": []
},
{
"id": "PMID-10229841_T2",
"type": "Protein",
"text": [
"TNF-alpha"
],
"offsets": [
... | [] | [] | [] |
149 | PMID-7843230 | [
{
"id": "PMID-7843230__text",
"type": "abstract",
"text": [
"Biphasic control of nuclear factor-kappa B activation by the T cell receptor complex: role of tumor necrosis factor alpha. \nThe regulation of nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex in primary hum... | [
{
"id": "PMID-7843230_T1",
"type": "Protein",
"text": [
"tumor necrosis factor alpha"
],
"offsets": [
[
94,
121
]
],
"normalized": []
},
{
"id": "PMID-7843230_T2",
"type": "Protein",
"text": [
"p50"
],
"offsets": [
[
... | [] | [] | [] |
150 | PMID-8015553 | [
{
"id": "PMID-8015553__text",
"type": "abstract",
"text": [
"Nonpituitary human prolactin gene transcription is independent of Pit-1 and differentially controlled in lymphocytes and in endometrial stroma. \nExpression of the human PRL (hPRL) gene in extrapituitary sites such as the uterus (decidua... | [
{
"id": "PMID-8015553_T1",
"type": "Protein",
"text": [
"prolactin"
],
"offsets": [
[
19,
28
]
],
"normalized": []
},
{
"id": "PMID-8015553_T2",
"type": "Protein",
"text": [
"Pit-1"
],
"offsets": [
[
66,
... | [] | [] | [] |
152 | PMID-8773576 | [
{
"id": "PMID-8773576__text",
"type": "abstract",
"text": [
"The role of early growth response gene 1 (egr-1) in regulation of the immune response. \nThe induction of immediate early genes in cells of the immune system is critical to determining the ultimate outcome of exposure to antigen. The imp... | [
{
"id": "PMID-8773576_T1",
"type": "Protein",
"text": [
"early growth response gene 1"
],
"offsets": [
[
12,
40
]
],
"normalized": []
},
{
"id": "PMID-8773576_T2",
"type": "Protein",
"text": [
"egr-1"
],
"offsets": [
[... | [] | [] | [] |
153 | PMID-1945879 | [
{
"id": "PMID-1945879__text",
"type": "abstract",
"text": [
"One base pair change abolishes the T cell-restricted activity of a kB-like proto-enhancer element from the interleukin 2 promoter. \nThe inducible, T cell-specific enhancers of murine and human Interleukin 2 (Il-2) genes contain the kB-l... | [
{
"id": "PMID-1945879_T1",
"type": "Protein",
"text": [
"interleukin 2"
],
"offsets": [
[
107,
120
]
],
"normalized": []
},
{
"id": "PMID-1945879_T2",
"type": "Protein",
"text": [
"Interleukin 2"
],
"offsets": [
[
... | [] | [] | [] |
159 | PMID-10438731 | [
{
"id": "PMID-10438731__text",
"type": "abstract",
"text": [
"C/EBPbeta and GATA-1 synergistically regulate activity of the eosinophil granule major basic protein promoter: implication for C/EBPbeta activity in eosinophil gene expression. \nEosinophil granule major basic protein (MBP) is expressed... | [
{
"id": "PMID-10438731_T1",
"type": "Protein",
"text": [
"C/EBPbeta"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "PMID-10438731_T2",
"type": "Protein",
"text": [
"GATA-1"
],
"offsets": [
[
14,
... | [] | [] | [] |
160 | PMID-9312192 | [
{
"id": "PMID-9312192__text",
"type": "abstract",
"text": [
"Evidence that calcineurin is rate-limiting for primary human lymphocyte activation. \nCyclosporine (CsA) is both a clinical immunosuppressive drug and a probe to dissect intracellular signaling pathways. In vitro, CsA inhibits lymphocyte... | [
{
"id": "PMID-9312192_T1",
"type": "Protein",
"text": [
"IFN-gamma"
],
"offsets": [
[
908,
917
]
],
"normalized": []
},
{
"id": "PMID-9312192_T2",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
922,
... | [] | [] | [] |
161 | PMID-9649186 | [
{
"id": "PMID-9649186__text",
"type": "abstract",
"text": [
"Oxidative stress suppresses transcription factor activities in stimulated lymphocytes. \nEffects of oxidative stress on stimulation-dependent signal transduction, leading to IL-2 expression, were studied. Purified quiescent human blood T... | [
{
"id": "PMID-9649186_T1",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
173,
177
]
],
"normalized": []
}
] | [] | [] | [] |
163 | PMID-9341756 | [
{
"id": "PMID-9341756__text",
"type": "abstract",
"text": [
"Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-kappa B. \nRecent studies from our laboratory have indic... | [
{
"id": "PMID-9341756_T1",
"type": "Protein",
"text": [
"intracellular adhesion molecule (ICAM)-1"
],
"offsets": [
[
743,
783
]
],
"normalized": []
},
{
"id": "PMID-9341756_T2",
"type": "Protein",
"text": [
"vascular cell adhesion m... | [] | [] | [] |
164 | PMID-2023633 | [
{
"id": "PMID-2023633__text",
"type": "abstract",
"text": [
"HIV enhancer activity perpetuated by NF-kappa B induction on infection of monocytes [see comments] \nPermissiveness to replication of human immunodeficiency virus (HIV) differs in T lymphocytes and macrophages. In T cells, HIV transcript... | [] | [] | [] | [] |
168 | PMID-10082134 | [
{
"id": "PMID-10082134__text",
"type": "abstract",
"text": [
"Cobalt chloride-induced signaling in endothelium leading to the augmented adherence of sickle red blood cells and transendothelial migration of monocyte-like HL-60 cells is blocked by PAF-receptor antagonist. \nIn response to hypoxia, s... | [
{
"id": "PMID-10082134_T1",
"type": "Protein",
"text": [
"PAF-receptor"
],
"offsets": [
[
184,
196
]
],
"normalized": []
},
{
"id": "PMID-10082134_T2",
"type": "Protein",
"text": [
"VCAM-1"
],
"offsets": [
[
72... | [] | [] | [] |
170 | PMID-7565732 | [
{
"id": "PMID-7565732__text",
"type": "abstract",
"text": [
"Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. \nT-lymphocyte proliferation is suppressed by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], th... | [
{
"id": "PMID-7565732_T1",
"type": "Protein",
"text": [
"interleukin-2"
],
"offsets": [
[
34,
47
]
],
"normalized": []
},
{
"id": "PMID-7565732_T2",
"type": "Protein",
"text": [
"NFATp"
],
"offsets": [
[
89,
... | [] | [] | [] |
172 | PMID-8018558 | [
{
"id": "PMID-8018558__text",
"type": "abstract",
"text": [
"Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation. \nThe present work has studied mechanisms responsible for induction of early growth response 1 (EGR-1) gene expression du... | [
{
"id": "PMID-8018558_T1",
"type": "Protein",
"text": [
"early growth response 1"
],
"offsets": [
[
14,
37
]
],
"normalized": []
},
{
"id": "PMID-8018558_T2",
"type": "Protein",
"text": [
"early growth response 1"
],
"offset... | [] | [] | [] |
176 | PMID-2234062 | [
{
"id": "PMID-2234062__text",
"type": "abstract",
"text": [
"Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs. \nWe have cloned and characterized a mitogen-inducible gene isolated from human T cells that predicts ... | [] | [] | [] | [] |
178 | PMID-8934542 | [
{
"id": "PMID-8934542__text",
"type": "abstract",
"text": [
"Cell specific expression of human Bruton's agammaglobulinemia tyrosine kinase gene (Btk) is regulated by Sp1- and Spi-1/PU.1-family members. \nBruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase involved in... | [
{
"id": "PMID-8934542_T1",
"type": "Protein",
"text": [
"Bruton's agammaglobulinemia tyrosine kinase"
],
"offsets": [
[
34,
77
]
],
"normalized": []
},
{
"id": "PMID-8934542_T2",
"type": "Protein",
"text": [
"Btk"
],
"offset... | [] | [] | [] |
179 | PMID-10358756 | [
{
"id": "PMID-10358756__text",
"type": "abstract",
"text": [
"Transcriptional regulation of T lymphocyte development and function. \nThe development and function of T lymphocytes are regulated tightly by signal transduction pathways that include specific cell-surface receptors, intracellular signa... | [
{
"id": "PMID-10358756_T1",
"type": "Protein",
"text": [
"Ikaros"
],
"offsets": [
[
410,
416
]
],
"normalized": []
},
{
"id": "PMID-10358756_T2",
"type": "Protein",
"text": [
"LKLF"
],
"offsets": [
[
418,
... | [] | [] | [] |
180 | PMID-1386962 | [
{
"id": "PMID-1386962__text",
"type": "abstract",
"text": [
"The development of functionally responsive T cells. \nThe work reviewed in this article separates T cell development into four phases. First is an expansion phase prior to TCR rearrangement, which appears to be correlated with programmin... | [
{
"id": "PMID-1386962_T1",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
1766,
1770
]
],
"normalized": []
},
{
"id": "PMID-1386962_T2",
"type": "Protein",
"text": [
"IL-2R alpha"
],
"offsets": [
[
2063,... | [] | [] | [] |
183 | PMID-8054477 | [
{
"id": "PMID-8054477__text",
"type": "abstract",
"text": [
"Positive and negative regulation of IL-2 gene expression: role of multiple regulatory sites. \nInterleukin 2 (IL-2) is an important lymphokine required in the process of T cell activation, proliferation, clonal expansion and differentiat... | [
{
"id": "PMID-8054477_T1",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
36,
40
]
],
"normalized": []
},
{
"id": "PMID-8054477_T2",
"type": "Protein",
"text": [
"Interleukin 2"
],
"offsets": [
[
94,
... | [] | [] | [] |
187 | PMID-9834092 | [
{
"id": "PMID-9834092__text",
"type": "abstract",
"text": [
"Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50. \nActivation of T lymphocytes by Ags or cytokines results in... | [
{
"id": "PMID-9834092_T1",
"type": "Protein",
"text": [
"STAT1"
],
"offsets": [
[
42,
47
]
],
"normalized": []
},
{
"id": "PMID-9834092_T2",
"type": "Protein",
"text": [
"p50"
],
"offsets": [
[
172,
175... | [] | [] | [] |
188 | PMID-8018594 | [
{
"id": "PMID-8018594__text",
"type": "abstract",
"text": [
"Effects of prostaglandin E2 on Th0-type human T cell clones: modulation of functions of nuclear proteins involved in cytokine production. \nThe effects of prostaglandin E2 (PGE2) on cytokine production and proliferation of the CD4+ human... | [
{
"id": "PMID-8018594_T1",
"type": "Protein",
"text": [
"CD4"
],
"offsets": [
[
226,
229
]
],
"normalized": []
},
{
"id": "PMID-8018594_T2",
"type": "Protein",
"text": [
"IL-4"
],
"offsets": [
[
507,
51... | [] | [] | [] |
189 | PMID-9933632 | [
{
"id": "PMID-9933632__text",
"type": "abstract",
"text": [
"NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro. \nDuring beneficial inflammation, potentially tissue-damaging granulocytes undergo apoptosis before being cleared by phagocytes in a non-phlogistic man... | [
{
"id": "PMID-9933632_T1",
"type": "Protein",
"text": [
"tumor necrosis factor-alpha"
],
"offsets": [
[
906,
933
]
],
"normalized": []
},
{
"id": "PMID-9933632_T2",
"type": "Protein",
"text": [
"TNF-alpha"
],
"offsets": [
... | [] | [] | [] |
192 | PMID-9057086 | [
{
"id": "PMID-9057086__text",
"type": "abstract",
"text": [
"Differentiation of U-937 promonocytic cells by etoposide and ICRF-193, two antitumour DNA topoisomerase II inhibitors with different mechanisms of action. \nWe have compared the action on U-937 human promonocytic leukemia cells of two DN... | [
{
"id": "PMID-9057086_T1",
"type": "Protein",
"text": [
"EGR-1"
],
"offsets": [
[
1519,
1524
]
],
"normalized": []
}
] | [] | [] | [] |
End of preview. Expand
in Data Studio
Dataset Card for GENIA Relation Corpus
The extraction of various relations stated to hold between biomolecular entities is one of the most frequently addressed information extraction tasks in domain studies. Typical relation extraction targets involve protein-protein interactions or gene regulatory relations. However, in the GENIA corpus, such associations involving change in the state or properties of biomolecules are captured in the event annotation.
The GENIA corpus relation annotation aims to complement the event annotation of the corpus by capturing (primarily) static relations, relations such as part-of that hold between entities without (necessarily) involving change.
Citation Information
@inproceedings{pyysalo-etal-2009-static,
title = "Static Relations: a Piece in the Biomedical Information Extraction Puzzle",
author = "Pyysalo, Sampo and
Ohta, Tomoko and
Kim, Jin-Dong and
Tsujii, Jun{'}ichi",
booktitle = "Proceedings of the {B}io{NLP} 2009 Workshop",
month = jun,
year = "2009",
address = "Boulder, Colorado",
publisher = "Association for Computational Linguistics",
url = "https://aclanthology.org/W09-1301",
pages = "1--9",
}
@article{article,
author = {Ohta, Tomoko and Pyysalo, Sampo and Kim, Jin-Dong and Tsujii, Jun'ichi},
year = {2010},
month = {10},
pages = {917-28},
title = {A reevaluation of biomedical named entity - term relations},
volume = {8},
journal = {Journal of bioinformatics and computational biology},
doi = {10.1142/S0219720010005014}
}
@MISC{Hoehndorf_applyingontology,
author = {Robert Hoehndorf and Axel-cyrille Ngonga Ngomo and Sampo Pyysalo and Tomoko Ohta and Anika Oellrich and
Dietrich Rebholz-schuhmann},
title = {Applying ontology design patterns to the implementation of relations in GENIA},
year = {}
}
- Downloads last month
- 54