id stringlengths 7 9 | document_id stringlengths 7 8 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
IEPA.d0 | 1645753 | [
{
"id": "IEPA.d0.s0",
"type": "",
"text": [
"Oxytocin stimulates IP3 production in dose-dependent fashion as well"
],
"offsets": [
[
0,
68
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]
}
] | [
{
"id": "IEPA.d0.s0.e0",
"type": "",
"text": [
"Oxytocin"
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0,
8
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{
"id": "IEPA.d0.s0.e1",
"type": "",
"text": [
"IP3"
],
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20,
23
]
],
... | [] | [] | [
{
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"arg2_id": "IEPA.d0.s0.e1",
"normalized": []
}
] |
IEPA.d1 | 1936930 | [
{
"id": "IEPA.d1.s1",
"type": "",
"text": [
"Phosphoinositide hydrolysis, resulting in inositol trisphosphate (IP3) and diacylglycerol (DG) formation, has been implicated in oxytocin-stimulated pulsatile secretion of prostaglandin F2 alpha (PGF2 alpha) from uterine endometrium of sheep and other m... | [
{
"id": "IEPA.d1.s1.e0",
"type": "",
"text": [
"inositol trisphosphate"
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42,
64
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{
"id": "IEPA.d1.s1.e1",
"type": "",
"text": [
"oxytocin"
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[
129,
... | [] | [] | [
{
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"type": "PPI",
"arg1_id": "IEPA.d1.s1.e0",
"arg2_id": "IEPA.d1.s1.e1",
"normalized": []
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] |
IEPA.d2 | 1963324 | [
{
"id": "IEPA.d2.s2",
"type": "",
"text": [
"SP ewes also had greater incorporation of [3H]inositol into inositol trisphosphate (IP3) (+3449%, p less than 0.01) and total inositol phosphate (IP) (+760%, p less than 0.08), in response to oxytocin, than did oCSP ewes (+553 and +168% for IP3 and tota... | [
{
"id": "IEPA.d2.s2.e0",
"type": "",
"text": [
"inositol trisphosphate"
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[
60,
82
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{
"id": "IEPA.d2.s2.e1",
"type": "",
"text": [
"inositol phosphate"
],
"offsets": [
[
12... | [] | [] | [
{
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{
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"arg1_id": "IEPA.d2.s2.e1",
"arg2_id": "IEPA.d2.s2.e2",
"normalized": []
},
{
"id": "IEPA.d2.s2.i2",
"ty... |
IEPA.d3 | 2163308 | [
{
"id": "IEPA.d3.s4",
"type": "",
"text": [
"Inositol 1,4,5-trisphosphate and oxytocin binding in human myometrium"
],
"offsets": [
[
0,
69
]
]
}
] | [
{
"id": "IEPA.d3.s4.e0",
"type": "",
"text": [
"Inositol 1,4,5-trisphosphate"
],
"offsets": [
[
0,
28
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],
"normalized": []
},
{
"id": "IEPA.d3.s4.e1",
"type": "",
"text": [
"oxytocin"
],
"offsets": [
[
33,
... | [] | [] | [] |
IEPA.d4 | 2229283 | [
{
"id": "IEPA.d4.s5",
"type": "",
"text": [
"The effects of prostaglandin F2 alpha (PGF2 alpha) on intracellular Ca2+ concentration ([Ca2+]i) and inositol phosphate (IP) generation in human myometrial cells were evaluated and compared to the effects of oxytocin"
],
"offsets": [
[
... | [
{
"id": "IEPA.d4.s5.e0",
"type": "",
"text": [
"inositol phosphate"
],
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[
101,
119
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],
"normalized": []
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{
"id": "IEPA.d4.s5.e1",
"type": "",
"text": [
"oxytocin"
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"offsets": [
[
208,
2... | [] | [] | [
{
"id": "IEPA.d4.s6.i0",
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"arg2_id": "IEPA.d4.s6.e1",
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{
"id": "IEPA.d4.s7.i0",
"type": "PPI",
"arg1_id": "IEPA.d4.s7.e0",
"arg2_id": "IEPA.d4.s7.e1",
"normalized": []
}
] |
IEPA.d8 | 7581972 | [
{
"id": "IEPA.d8.s14",
"type": "",
"text": [
"The objectives of this study were to evaluate and compare the actions of endothelin-1 (ET-1), oxytocin, prostaglandin F2 alpha (PGF2 alpha) and inositol 1,4,5-trisphosphate (IP3) on 45Ca2+ mobilization in permeabilized rat myometrial cells and to exami... | [
{
"id": "IEPA.d8.s14.e0",
"type": "",
"text": [
"oxytocin"
],
"offsets": [
[
94,
102
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],
"normalized": []
},
{
"id": "IEPA.d8.s14.e1",
"type": "",
"text": [
"inositol 1,4,5-trisphosphate"
],
"offsets": [
[
144... | [] | [] | [
{
"id": "IEPA.d8.s16.i0",
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"arg1_id": "IEPA.d8.s16.e0",
"arg2_id": "IEPA.d8.s16.e1",
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{
"id": "IEPA.d8.s17.i0",
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"arg1_id": "IEPA.d8.s17.e0",
"arg2_id": "IEPA.d8.s17.e1",
"normalized": []
}
] |
IEPA.d9 | 7619502 | [
{
"id": "IEPA.d9.s18",
"type": "",
"text": [
"Oxytocin induced a biphasic increase in the intracellular Ca2+ concentration of porcine myometrial cells: participation of a pertussis toxin-insensitive G-protein, inositol 1,4,5-trisphosphate-sensitive Ca2+ pool, and Ca2+ channels"
],
"offsets... | [
{
"id": "IEPA.d9.s18.e0",
"type": "",
"text": [
"Oxytocin"
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[
0,
8
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"normalized": []
},
{
"id": "IEPA.d9.s18.e1",
"type": "",
"text": [
"inositol 1,4,5-trisphosphate"
],
"offsets": [
[
164,
... | [] | [] | [
{
"id": "IEPA.d9.s19.i0",
"type": "PPI",
"arg1_id": "IEPA.d9.s19.e0",
"arg2_id": "IEPA.d9.s19.e1",
"normalized": []
},
{
"id": "IEPA.d9.s20.i0",
"type": "PPI",
"arg1_id": "IEPA.d9.s20.e0",
"arg2_id": "IEPA.d9.s20.e1",
"normalized": []
},
{
"id": "IEPA.d9.s21.i0",
... |
IEPA.d10 | 7700473 | [
{
"id": "IEPA.d10.s22",
"type": "",
"text": [
"Amyloid beta protein disruption of cholinergic and growth factor phospholipase C signals could underlie cognitive and neurodegerative aspects of Alzheimer's disease"
],
"offsets": [
[
0,
164
]
]
}
] | [
{
"id": "IEPA.d10.s22.e0",
"type": "",
"text": [
"Amyloid"
],
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[
0,
7
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],
"normalized": []
},
{
"id": "IEPA.d10.s22.e1",
"type": "",
"text": [
"phospholipase C"
],
"offsets": [
[
65,
80
... | [] | [] | [
{
"id": "IEPA.d10.s22.i0",
"type": "PPI",
"arg1_id": "IEPA.d10.s22.e0",
"arg2_id": "IEPA.d10.s22.e1",
"normalized": []
}
] |
IEPA.d11 | 7781763 | [
{
"id": "IEPA.d11.s23",
"type": "",
"text": [
"Amyloid beta protein (25-35) stimulation of phospholipases A, C and D activities of LA-N-2 cells"
],
"offsets": [
[
0,
96
]
]
},
{
"id": "IEPA.d11.s24",
"type": "",
"text": [
"[3H]Inositol ... | [
{
"id": "IEPA.d11.s23.e0",
"type": "",
"text": [
"Amyloid"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "IEPA.d11.s23.e1",
"type": "",
"text": [
"phospholipases"
],
"offsets": [
[
44,
58
... | [] | [] | [
{
"id": "IEPA.d11.s23.i0",
"type": "PPI",
"arg1_id": "IEPA.d11.s23.e0",
"arg2_id": "IEPA.d11.s23.e1",
"normalized": []
},
{
"id": "IEPA.d11.s25.i0",
"type": "PPI",
"arg1_id": "IEPA.d11.s25.e0",
"arg2_id": "IEPA.d11.s25.e1",
"normalized": []
},
{
"id": "IEPA.d11.s2... |
IEPA.d12 | 7876266 | [
{
"id": "IEPA.d12.s29",
"type": "",
"text": [
"These results suggest that APP-S secretion and A beta production in NT2N neurons are regulated by the muscarinic/phospholipase C signal transduction pathway"
],
"offsets": [
[
0,
156
]
]
}
] | [
{
"id": "IEPA.d12.s29.e0",
"type": "",
"text": [
"APP-S"
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[
27,
32
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],
"normalized": []
},
{
"id": "IEPA.d12.s29.e1",
"type": "",
"text": [
"A beta"
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[
47,
53
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... | [] | [] | [
{
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"normalized": []
},
{
"id": "IEPA.d12.s29.i1",
"type": "PPI",
"arg1_id": "IEPA.d12.s29.e1",
"arg2_id": "IEPA.d12.s29.e2",
"normalized": []
}
] |
IEPA.d13 | 7884548 | [
{
"id": "IEPA.d13.s30",
"type": "",
"text": [
"Current interest in reducing heart disease risks by diet involves attention to total fat; saturated, monounsaturated, polyunsaturated and trans fatty acids, as well as dietary cholesterol, soluble fiber, salt, alcohol, antioxidants, dietary alteration... | [
{
"id": "IEPA.d13.s30.e0",
"type": "",
"text": [
"cholesterol"
],
"offsets": [
[
176,
187
]
],
"normalized": []
},
{
"id": "IEPA.d13.s30.e1",
"type": "",
"text": [
"flavonoid"
],
"offsets": [
[
317,
326... | [] | [] | [] |
IEPA.d14 | 7960031 | [
{
"id": "IEPA.d14.s31",
"type": "",
"text": [
"This indicates that the calcium response to OT application was principally associated with activation of the IP3-sensitive calcium stores"
],
"offsets": [
[
0,
137
]
]
}
] | [
{
"id": "IEPA.d14.s31.e0",
"type": "",
"text": [
"OT"
],
"offsets": [
[
44,
46
]
],
"normalized": []
},
{
"id": "IEPA.d14.s31.e1",
"type": "",
"text": [
"IP3"
],
"offsets": [
[
109,
112
]
],
... | [] | [] | [] |
IEPA.d15 | 7986826 | [
{
"id": "IEPA.d15.s32",
"type": "",
"text": [
"The beta amyloid protein fragments had diverse effects on phosphoinositide-specific phospholipase C (PI-PLC) as assayed in rat cortical membranes"
],
"offsets": [
[
0,
145
]
]
}
] | [
{
"id": "IEPA.d15.s32.e0",
"type": "",
"text": [
"amyloid"
],
"offsets": [
[
9,
16
]
],
"normalized": []
},
{
"id": "IEPA.d15.s32.e1",
"type": "",
"text": [
"phospholipase C"
],
"offsets": [
[
84,
99
... | [] | [] | [
{
"id": "IEPA.d15.s32.i0",
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"arg1_id": "IEPA.d15.s32.e0",
"arg2_id": "IEPA.d15.s32.e1",
"normalized": []
}
] |
IEPA.d16 | 8324162 | [
{
"id": "IEPA.d16.s33",
"type": "",
"text": [
"They are needed for the catabolism of cholesterol, bile acids, and steroid hormones; they hydrolyze a number of flavonoid glycosides to anticarcinogens; and they detoxify certain carcinogens"
],
"offsets": [
[
0,
190
... | [
{
"id": "IEPA.d16.s33.e0",
"type": "",
"text": [
"cholesterol"
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[
38,
49
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"normalized": []
},
{
"id": "IEPA.d16.s33.e1",
"type": "",
"text": [
"flavonoid"
],
"offsets": [
[
112,
121
... | [] | [] | [] |
IEPA.d17 | 8527814 | [
{
"id": "IEPA.d17.s34",
"type": "",
"text": [
"The aim of this study was to investigate the effects of hCG, hCG plus oxytocin and oxytocin on [3H] inositol phosphate (IP) formations in porcine myometrial cells obtained from ovariectomized and cyclic gilts"
],
"offsets": [
[
0... | [
{
"id": "IEPA.d17.s34.e0",
"type": "",
"text": [
"oxytocin"
],
"offsets": [
[
70,
78
]
],
"normalized": []
},
{
"id": "IEPA.d17.s34.e1",
"type": "",
"text": [
"oxytocin"
],
"offsets": [
[
83,
91
]... | [] | [] | [
{
"id": "IEPA.d17.s34.i0",
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"arg2_id": "IEPA.d17.s34.e2",
"normalized": []
},
{
"id": "IEPA.d17.s34.i1",
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"arg2_id": "IEPA.d17.s34.e2",
"normalized": []
},
{
"id": "IEPA.d17.s3... |
IEPA.d18 | 8597679 | [
{
"id": "IEPA.d18.s40",
"type": "",
"text": [
"The relative risks between highest and lowest quarters of flavonoid intake adjusted for age, smoking, serum cholesterol concentration, blood pressure, and body mass index were 0.69 (95% confidence interval 0.53 to 0.90) and 0.54 (0.33 to 0.87) for tot... | [
{
"id": "IEPA.d18.s40.e0",
"type": "",
"text": [
"flavonoid"
],
"offsets": [
[
58,
67
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],
"normalized": []
},
{
"id": "IEPA.d18.s40.e1",
"type": "",
"text": [
"cholesterol"
],
"offsets": [
[
108,
119
... | [] | [] | [] |
IEPA.d19 | 8647319 | [
{
"id": "IEPA.d19.s41",
"type": "",
"text": [
"Granulosa cells were isolated from bovine preovulatory follicles and cultured for 3 days with or without OT in medium supplemented with either insulin (1 microgram/ml) + 1% fetal calf serum (FCS), which maintains basal estradiol secretion, or low dose... | [
{
"id": "IEPA.d19.s41.e0",
"type": "",
"text": [
"OT"
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"offsets": [
[
105,
107
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],
"normalized": []
},
{
"id": "IEPA.d19.s41.e1",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
143,
150
]
... | [] | [] | [] |
IEPA.d20 | 8713996 | [
{
"id": "IEPA.d20.s42",
"type": "",
"text": [
"We propose that OT binds to specific OT receptors (OTR) on the endometrium to stimulate phosphoinositide (PI) hydrolysis, thereby activating the inositol trisphosphate (IP3)-diacylglycerol (DAG) second-messenger system to promote pulsatile PGF2 alpha ... | [
{
"id": "IEPA.d20.s42.e0",
"type": "",
"text": [
"OT"
],
"offsets": [
[
16,
18
]
],
"normalized": []
},
{
"id": "IEPA.d20.s42.e1",
"type": "",
"text": [
"IP3"
],
"offsets": [
[
169,
172
]
],
... | [] | [] | [
{
"id": "IEPA.d20.s42.i0",
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"arg2_id": "IEPA.d20.s42.e1",
"normalized": []
},
{
"id": "IEPA.d20.s43.i0",
"type": "PPI",
"arg1_id": "IEPA.d20.s43.e0",
"arg2_id": "IEPA.d20.s43.e1",
"normalized": []
},
{
"id": "IEPA.d20.s4... |
IEPA.d21 | 8713999 | [
{
"id": "IEPA.d21.s45",
"type": "",
"text": [
"These data suggest that cAMP-dependent phosphorylation at a step involving GTP-binding protein/PLC coupling can exert a negative effect on the stimulation of IP3 formation by oxytocin and thereby affect contraction/relaxation in the myometrium"
],... | [
{
"id": "IEPA.d21.s45.e0",
"type": "",
"text": [
"IP3"
],
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[
158,
161
]
],
"normalized": []
},
{
"id": "IEPA.d21.s45.e1",
"type": "",
"text": [
"oxytocin"
],
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[
175,
183
]
... | [] | [] | [
{
"id": "IEPA.d21.s45.i0",
"type": "PPI",
"arg1_id": "IEPA.d21.s45.e0",
"arg2_id": "IEPA.d21.s45.e1",
"normalized": []
}
] |
IEPA.d22 | 8735881 | [
{
"id": "IEPA.d22.s46",
"type": "",
"text": [
"Once the abnormally phosphorylated abnormal prion protein isoform agent is initiated, any stress event ensuing in adult life induces a nerve growth factor-mediated synthesis of normal cellular prion protein isoform that aggregates to abnormally phosph... | [
{
"id": "IEPA.d22.s46.e0",
"type": "",
"text": [
"prion protein"
],
"offsets": [
[
44,
57
]
],
"normalized": []
},
{
"id": "IEPA.d22.s46.e1",
"type": "",
"text": [
"prion protein"
],
"offsets": [
[
193,
... | [] | [] | [
{
"id": "IEPA.d22.s46.i0",
"type": "PPI",
"arg1_id": "IEPA.d22.s46.e3",
"arg2_id": "IEPA.d22.s46.e4",
"normalized": []
}
] |
IEPA.d23 | 8735882 | [
{
"id": "IEPA.d23.s47",
"type": "",
"text": [
"The resulting abnormally phosphorylated PrPsc aggregates to freshly synthesized PrPc, transforming it into same; due to a system of positive feedback invoked by the organophosphate-induced blockage of a prion protein-specific protein kinase."
],
... | [
{
"id": "IEPA.d23.s47.e0",
"type": "",
"text": [
"PrPsc"
],
"offsets": [
[
40,
45
]
],
"normalized": []
},
{
"id": "IEPA.d23.s47.e1",
"type": "",
"text": [
"PrPc"
],
"offsets": [
[
80,
84
]
],... | [] | [] | [
{
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"type": "PPI",
"arg1_id": "IEPA.d23.s47.e2",
"arg2_id": "IEPA.d23.s47.e3",
"normalized": []
}
] |
IEPA.d24 | 8739893 | [
{
"id": "IEPA.d24.s48",
"type": "",
"text": [
"The aim of the present study was to investigate how oxytocin given subcutaneously (SC) and intracerebroventricularly (ICV) influences the secretion of insulin, glucagon and glucose and to investigate whether the effect on these variables of suckling i... | [
{
"id": "IEPA.d24.s48.e0",
"type": "",
"text": [
"oxytocin"
],
"offsets": [
[
52,
60
]
],
"normalized": []
},
{
"id": "IEPA.d24.s48.e1",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
151,
158
... | [] | [] | [
{
"id": "IEPA.d24.s48.i0",
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"arg2_id": "IEPA.d24.s48.e1",
"normalized": []
},
{
"id": "IEPA.d24.s49.i0",
"type": "PPI",
"arg1_id": "IEPA.d24.s49.e0",
"arg2_id": "IEPA.d24.s49.e1",
"normalized": []
},
{
"id": "IEPA.d24.s5... |
IEPA.d25 | 8771561 | [
{
"id": "IEPA.d25.s54",
"type": "",
"text": [
"The responses of serum oxytocin (OT) and vasopressin (AVP) to the serotonergic HT1A agonist buspirone (15 mg p.o.) or the HTD1 agonist sumatriptan (6 mg injected subcutaneously) were evaluated in 7 normal men either in basal conditions or during an in... | [
{
"id": "IEPA.d25.s54.e0",
"type": "",
"text": [
"oxytocin"
],
"offsets": [
[
23,
31
]
],
"normalized": []
},
{
"id": "IEPA.d25.s54.e1",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
249,
256
... | [] | [] | [
{
"id": "IEPA.d25.s55.i0",
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"arg2_id": "IEPA.d25.s55.e1",
"normalized": []
}
] |
IEPA.d26 | 8777160 | [
{
"id": "IEPA.d26.s56",
"type": "",
"text": [
"The SGR and RGR also had different endocrine profiles with, for example, twice as high oxytocin (p < 0.01) and insulin levels (p < 0.01) in RGR compared to the SGR"
],
"offsets": [
[
0,
163
]
]
}
] | [
{
"id": "IEPA.d26.s56.e0",
"type": "",
"text": [
"oxytocin"
],
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[
87,
95
]
],
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},
{
"id": "IEPA.d26.s56.e1",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
111,
118
... | [] | [] | [] |
IEPA.d27 | 8795088 | [
{
"id": "IEPA.d27.s57",
"type": "",
"text": [
"8-OH-DPAT also increased insulin and decreased CCK and somatostatin levels, effects that were blocked by pretreatment with the oxytocin antagonist"
],
"offsets": [
[
0,
146
]
]
},
{
"id": "IEPA.d27.s58",... | [
{
"id": "IEPA.d27.s57.e0",
"type": "",
"text": [
"insulin"
],
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[
25,
32
]
],
"normalized": []
},
{
"id": "IEPA.d27.s57.e1",
"type": "",
"text": [
"oxytocin"
],
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[
127,
135
... | [] | [] | [
{
"id": "IEPA.d27.s57.i0",
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{
"id": "IEPA.d27.s58.i0",
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"arg2_id": "IEPA.d27.s58.e1",
"normalized": []
},
{
"id": "IEPA.d27.s5... |
IEPA.d28 | 8851493 | [
{
"id": "IEPA.d28.s60",
"type": "",
"text": [
"In HVSMC both oxytocin and AVP increased inositol 1,4,5-trisphosphate (IP3) production and [Ca2+]i response, but the efficacy of the responses was greater for oxytocin than AVP"
],
"offsets": [
[
0,
176
]
]
}
... | [
{
"id": "IEPA.d28.s60.e0",
"type": "",
"text": [
"oxytocin"
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[
14,
22
]
],
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},
{
"id": "IEPA.d28.s60.e1",
"type": "",
"text": [
"inositol 1,4,5-trisphosphate"
],
"offsets": [
[
41... | [] | [] | [
{
"id": "IEPA.d28.s60.i0",
"type": "PPI",
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"arg2_id": "IEPA.d28.s60.e1",
"normalized": []
}
] |
IEPA.d31 | 8886594 | [
{
"id": "IEPA.d31.s63",
"type": "",
"text": [
"OT may rapidly stimulate inositol (1,4,5)-trisphosphate (IP3) and diacylglycerol (DAG) formation, consistent with the concept of rapid activation of a second-messenger system"
],
"offsets": [
[
0,
174
]
]
},
... | [
{
"id": "IEPA.d31.s63.e0",
"type": "",
"text": [
"OT"
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[
0,
2
]
],
"normalized": []
},
{
"id": "IEPA.d31.s63.e1",
"type": "",
"text": [
"inositol (1,4,5)-trisphosphate"
],
"offsets": [
[
25,
... | [] | [] | [
{
"id": "IEPA.d31.s63.i0",
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},
{
"id": "IEPA.d31.s64.i0",
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"arg2_id": "IEPA.d31.s64.e1",
"normalized": []
},
{
"id": "IEPA.d31.s6... |
IEPA.d32 | 8952001 | [
{
"id": "IEPA.d32.s66",
"type": "",
"text": [
"Gamma-aminobutyric acid mediation of the inhibitory effect of nitric oxide on the arginine vasopressin and oxytocin responses to insulin-induced hypoglycemia"
],
"offsets": [
[
0,
157
]
]
},
{
"id": "IEP... | [
{
"id": "IEPA.d32.s66.e0",
"type": "",
"text": [
"oxytocin"
],
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[
107,
115
]
],
"normalized": []
},
{
"id": "IEPA.d32.s66.e1",
"type": "",
"text": [
"insulin"
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"offsets": [
[
129,
136
... | [] | [] | [
{
"id": "IEPA.d32.s66.i0",
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},
{
"id": "IEPA.d32.s67.i0",
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"arg2_id": "IEPA.d32.s67.e1",
"normalized": []
},
{
"id": "IEPA.d32.s6... |
IEPA.d33 | 8987334 | [
{
"id": "IEPA.d33.s71",
"type": "",
"text": [
"Correlation between the stimulatory effect of oxytocin on the formation of inositol phosphates and the oxytocin receptor level in the pregnant rabbit myometrium"
],
"offsets": [
[
0,
160
]
]
},
{
"id": "... | [
{
"id": "IEPA.d33.s71.e0",
"type": "",
"text": [
"oxytocin"
],
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[
46,
54
]
],
"normalized": []
},
{
"id": "IEPA.d33.s71.e1",
"type": "",
"text": [
"inositol phosphates"
],
"offsets": [
[
75,
... | [] | [] | [
{
"id": "IEPA.d33.s71.i0",
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},
{
"id": "IEPA.d33.s72.i0",
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"arg2_id": "IEPA.d33.s72.e2",
"normalized": []
},
{
"id": "IEPA.d33.s7... |
IEPA.d34 | 9003017 | [
{
"id": "IEPA.d34.s80",
"type": "",
"text": [
"Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue"
],
"offsets": [
[
0,
99
]
]
},
{
"id": "IEPA.d34.s81",
"type": "",
"text": [
"To establi... | [
{
"id": "IEPA.d34.s80.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
36,
42
]
],
"normalized": []
},
{
"id": "IEPA.d34.s80.e1",
"type": "",
"text": [
"uncoupling protein"
],
"offsets": [
[
47,
65... | [] | [] | [] |
IEPA.d36 | 9005971 | [
{
"id": "IEPA.d36.s87",
"type": "",
"text": [
"Wortmannin converts insulin but not oxytocin from an antilipolytic to a lipolytic agent in the presence of forskolin"
],
"offsets": [
[
0,
116
]
]
},
{
"id": "IEPA.d36.s88",
"type": "",
"text": [... | [
{
"id": "IEPA.d36.s87.e0",
"type": "",
"text": [
"insulin"
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20,
27
]
],
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},
{
"id": "IEPA.d36.s87.e1",
"type": "",
"text": [
"oxytocin"
],
"offsets": [
[
36,
44
]
... | [] | [] | [] |
IEPA.d37 | 9013600 | [
{
"id": "IEPA.d37.s91",
"type": "",
"text": [
"These findings support the concept that the mitochondrial metabolism of nutrient molecules is an event sufficient to acutely augment insulin release from the beta cell, to increase phospholipase C-mediated phosphoinositide hydrolysis, and to induce ti... | [
{
"id": "IEPA.d37.s91.e0",
"type": "",
"text": [
"insulin"
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133,
140
]
],
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},
{
"id": "IEPA.d37.s91.e1",
"type": "",
"text": [
"phospholipase C"
],
"offsets": [
[
181,
1... | [] | [] | [] |
IEPA.d38 | 9057099 | [
{
"id": "IEPA.d38.s92",
"type": "",
"text": [
"2) IGF-1, IGF-2, and insulin also induced a Ca2+ mobilization from the endoplasmic reticulum: phospholipase C (PLC) inhibitors, neomycin, or U-73122 partially blocked the intracellular [Ca2+]i increase induced by IGF-1 and insulin and totally inhibite... | [
{
"id": "IEPA.d38.s92.e0",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
21,
28
]
],
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},
{
"id": "IEPA.d38.s92.e1",
"type": "",
"text": [
"phospholipase C"
],
"offsets": [
[
94,
109
... | [] | [] | [
{
"id": "IEPA.d38.s92.i0",
"type": "PPI",
"arg1_id": "IEPA.d38.s92.e1",
"arg2_id": "IEPA.d38.s92.e2",
"normalized": []
}
] |
IEPA.d39 | 9126376 | [
{
"id": "IEPA.d39.s93",
"type": "",
"text": [
"Homogeneous liposome immunoassay for insulin using phospholipase C from Clostridium perfringens"
],
"offsets": [
[
0,
95
]
]
},
{
"id": "IEPA.d39.s94",
"type": "",
"text": [
"Insulin was co... | [
{
"id": "IEPA.d39.s93.e0",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
37,
44
]
],
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},
{
"id": "IEPA.d39.s93.e1",
"type": "",
"text": [
"phospholipase C"
],
"offsets": [
[
51,
66
... | [] | [] | [] |
IEPA.d40 | 9135570 | [
{
"id": "IEPA.d40.s96",
"type": "",
"text": [
"Roles of GTP and phospholipase C in the potentiation of Ca(2+)-induced insulin secretion by glucose in rat pancreatic islets"
],
"offsets": [
[
0,
124
]
]
},
{
"id": "IEPA.d40.s97",
"type": "",
"... | [
{
"id": "IEPA.d40.s96.e0",
"type": "",
"text": [
"phospholipase C"
],
"offsets": [
[
17,
32
]
],
"normalized": []
},
{
"id": "IEPA.d40.s96.e1",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
71,
78
... | [] | [] | [] |
IEPA.d41 | 9142890 | [
{
"id": "IEPA.d41.s100",
"type": "",
"text": [
"Regulation of insulin secretion via ATP-sensitive K+ channel independent mechanisms: role of phospholipase C"
],
"offsets": [
[
0,
108
]
]
},
{
"id": "IEPA.d41.s101",
"type": "",
"text": [
... | [
{
"id": "IEPA.d41.s100.e0",
"type": "",
"text": [
"insulin"
],
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[
14,
21
]
],
"normalized": []
},
{
"id": "IEPA.d41.s100.e1",
"type": "",
"text": [
"phospholipase C"
],
"offsets": [
[
93,
10... | [] | [] | [
{
"id": "IEPA.d41.s100.i0",
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"arg2_id": "IEPA.d41.s100.e1",
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},
{
"id": "IEPA.d41.s101.i0",
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"arg1_id": "IEPA.d41.s101.e0",
"arg2_id": "IEPA.d41.s101.e1",
"normalized": []
},
{
"id": "IEPA.... |
IEPA.d43 | 9177227 | [
{
"id": "IEPA.d43.s108",
"type": "",
"text": [
"Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation"
],
"offsets": [
[
0,
79
]
]
},
{
"id": "IEPA.d43.s109",
"type": "",
"text": [
"Here we show that leptin alt... | [
{
"id": "IEPA.d43.s108.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
13,
19
]
],
"normalized": []
},
{
"id": "IEPA.d43.s108.e1",
"type": "",
"text": [
"uncoupling protein-2"
],
"offsets": [
[
23,
... | [] | [] | [
{
"id": "IEPA.d43.s108.i0",
"type": "PPI",
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"normalized": []
},
{
"id": "IEPA.d43.s109.i0",
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"arg1_id": "IEPA.d43.s109.e0",
"arg2_id": "IEPA.d43.s109.e1",
"normalized": []
},
{
"id": "IEPA.... |
IEPA.d44 | 9186274 | [
{
"id": "IEPA.d44.s112",
"type": "",
"text": [
"Further, the oxytocin-induced activation of IK(sl) was effectively antagonized by 5 x 10(-8) mol/l U-73122 or 5 x 10(-6) mol/l 2-nitro-4-carboxyphenyl N,N-diphenylcarbamate (inhibitors of the cell membrane phospholipase C), as well as by intracellula... | [
{
"id": "IEPA.d44.s112.e0",
"type": "",
"text": [
"oxytocin"
],
"offsets": [
[
13,
21
]
],
"normalized": []
},
{
"id": "IEPA.d44.s112.e1",
"type": "",
"text": [
"inositol-1,4,5-trisphosphate"
],
"offsets": [
[
... | [] | [] | [] |
IEPA.d45 | 9187302 | [
{
"id": "IEPA.d45.s114",
"type": "",
"text": [
"Cellular preincubation with 200 microg/ml antibodies against the inositolphosphoglycan (IPG) moiety of the GPI-anchor (Ab(IPG)), or depletion in GPI-anchored proteins by cellular pretreatment with 0.5 U/ml PI-PLC, 1 mM insulin and 2 HU/ml streptolysi... | [
{
"id": "IEPA.d45.s114.e0",
"type": "",
"text": [
"PLC"
],
"offsets": [
[
209,
212
]
],
"normalized": []
},
{
"id": "IEPA.d45.s114.e1",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
219,
226
]... | [] | [] | [] |
IEPA.d48 | 9252501 | [
{
"id": "IEPA.d48.s123",
"type": "",
"text": [
"Leptin increases uncoupling protein expression and energy expenditure"
],
"offsets": [
[
0,
69
]
]
},
{
"id": "IEPA.d48.s124",
"type": "",
"text": [
"Leptin increased BAT UCP mRNA levels g... | [
{
"id": "IEPA.d48.s123.e0",
"type": "",
"text": [
"Leptin"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "IEPA.d48.s123.e1",
"type": "",
"text": [
"uncoupling protein"
],
"offsets": [
[
17,
35... | [] | [] | [
{
"id": "IEPA.d48.s123.i0",
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"id": "IEPA.d48.s124.i0",
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"arg2_id": "IEPA.d48.s124.e1",
"normalized": []
},
{
"id": "IEPA.... |
IEPA.d52 | 9305858 | [
{
"id": "IEPA.d52.s135",
"type": "",
"text": [
"Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin"
],
"offsets": [
[
0,
119
]
]
},
{
"id": "IEPA.d52.s136",
"type": "",
"tex... | [
{
"id": "IEPA.d52.s135.e0",
"type": "",
"text": [
"Uncoupling protein-3"
],
"offsets": [
[
0,
20
]
],
"normalized": []
},
{
"id": "IEPA.d52.s135.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
113,
... | [] | [] | [
{
"id": "IEPA.d52.s135.i0",
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},
{
"id": "IEPA.d52.s136.i0",
"type": "PPI",
"arg1_id": "IEPA.d52.s136.e0",
"arg2_id": "IEPA.d52.s136.e1",
"normalized": []
}
] |
IEPA.d54 | 9366557 | [
{
"id": "IEPA.d54.s138",
"type": "",
"text": [
"This effect is maximal at 10(-8) M AVP (a concentration clearly above the normal physiological range of AVP concentrations) and involves the V2 receptor pathway, while activation of protein kinase C or changes in intracellular calcium are ineffective... | [
{
"id": "IEPA.d54.s138.e0",
"type": "",
"text": [
"AVP"
],
"offsets": [
[
104,
107
]
],
"normalized": []
},
{
"id": "IEPA.d54.s138.e1",
"type": "",
"text": [
"AVP"
],
"offsets": [
[
35,
38
]
]... | [] | [] | [] |
IEPA.d55 | 9369264 | [
{
"id": "IEPA.d55.s139",
"type": "",
"text": [
"After protein kinase C activity was functionally depleted by treating cells with phorbol 12-myristate 13-acetate for 24 hours, AVP did not augment IL-1beta-induced NO production"
],
"offsets": [
[
0,
177
]
]
... | [
{
"id": "IEPA.d55.s139.e0",
"type": "",
"text": [
"protein kinase C"
],
"offsets": [
[
6,
22
]
],
"normalized": []
},
{
"id": "IEPA.d55.s139.e1",
"type": "",
"text": [
"AVP"
],
"offsets": [
[
127,
130
... | [] | [] | [
{
"id": "IEPA.d55.s140.i0",
"type": "PPI",
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"arg2_id": "IEPA.d55.s140.e1",
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},
{
"id": "IEPA.d55.s141.i0",
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"arg1_id": "IEPA.d55.s141.e0",
"arg2_id": "IEPA.d55.s141.e1",
"normalized": []
},
{
"id": "IEPA.... |
IEPA.d57 | 9389497 | [
{
"id": "IEPA.d57.s146",
"type": "",
"text": [
"Activation of EGFR overexpressing 3T3-L1 adipocytes leads to a 3.4 +/- 1.2-fold stimulation of PLC activity over basal levels vs. only 1.06 +/- 0.01-fold stimulation by insulin."
],
"offsets": [
[
0,
177
]
]
... | [
{
"id": "IEPA.d57.s146.e0",
"type": "",
"text": [
"PLC"
],
"offsets": [
[
95,
98
]
],
"normalized": []
},
{
"id": "IEPA.d57.s146.e1",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
169,
176
]
... | [] | [] | [
{
"id": "IEPA.d57.s146.i0",
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},
{
"id": "IEPA.d57.s147.i0",
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"arg1_id": "IEPA.d57.s147.e0",
"arg2_id": "IEPA.d57.s147.e1",
"normalized": []
}
] |
IEPA.d58 | 9397959 | [
{
"id": "IEPA.d58.s150",
"type": "",
"text": [
"We have recently shown that AVP causes a protein kinase C (PKC)-dependent increase in ACTH release and biosynthesis in ovine anterior pituitary cells"
],
"offsets": [
[
0,
149
]
]
},
{
"id": "IEPA.d58.s... | [
{
"id": "IEPA.d58.s150.e0",
"type": "",
"text": [
"AVP"
],
"offsets": [
[
28,
31
]
],
"normalized": []
},
{
"id": "IEPA.d58.s150.e1",
"type": "",
"text": [
"protein kinase C"
],
"offsets": [
[
41,
57
... | [] | [] | [
{
"id": "IEPA.d58.s150.i0",
"type": "PPI",
"arg1_id": "IEPA.d58.s150.e0",
"arg2_id": "IEPA.d58.s150.e1",
"normalized": []
},
{
"id": "IEPA.d58.s151.i0",
"type": "PPI",
"arg1_id": "IEPA.d58.s151.e0",
"arg2_id": "IEPA.d58.s151.e1",
"normalized": []
}
] |
IEPA.d60 | 9459490 | [
{
"id": "IEPA.d60.s155",
"type": "",
"text": [
"The activity of the MAPKs, induced by AVP or PMA was inhibited by downregulation of protein kinase C (PKC), by the tyrosine kinase inhibitor genistein and by MAPK kinase (MEK) inhibitor, PD98059"
],
"offsets": [
[
0,
194... | [
{
"id": "IEPA.d60.s155.e0",
"type": "",
"text": [
"AVP"
],
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[
38,
41
]
],
"normalized": []
},
{
"id": "IEPA.d60.s155.e1",
"type": "",
"text": [
"protein kinase C"
],
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[
84,
100
... | [] | [] | [
{
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"arg2_id": "IEPA.d60.s156.e1",
"normalized": []
}
] |
IEPA.d61 | 9473570 | [
{
"id": "IEPA.d61.s157",
"type": "",
"text": [
"Secreted form of beta-amyloid precursor protein activates protein kinase C and phospholipase Cgamma1 in cultured embryonic rat neocortical cells"
],
"offsets": [
[
0,
144
]
]
},
{
"id": "IEPA.d61.s158",... | [
{
"id": "IEPA.d61.s157.e0",
"type": "",
"text": [
"beta-amyloid"
],
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[
17,
29
]
],
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},
{
"id": "IEPA.d61.s157.e1",
"type": "",
"text": [
"phospholipase Cgamma1"
],
"offsets": [
[
79,... | [] | [] | [
{
"id": "IEPA.d61.s157.i0",
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"arg2_id": "IEPA.d61.s158.e1",
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}
] |
IEPA.d62 | 9505272 | [
{
"id": "IEPA.d62.s159",
"type": "",
"text": [
"Oxytocin-treated male rats had increased circulating levels of cholecystokinin, a tendency to increased plasma levels of insulin (p = 0.066), and relatively more adipose tissue in the thigh and interscapular region, compared with controls"
],
... | [
{
"id": "IEPA.d62.s159.e0",
"type": "",
"text": [
"Oxytocin"
],
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0,
8
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],
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},
{
"id": "IEPA.d62.s159.e1",
"type": "",
"text": [
"insulin"
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[
121,
128
... | [] | [] | [
{
"id": "IEPA.d62.s159.i0",
"type": "PPI",
"arg1_id": "IEPA.d62.s159.e0",
"arg2_id": "IEPA.d62.s159.e1",
"normalized": []
}
] |
IEPA.d63 | 9520493 | [
{
"id": "IEPA.d63.s160",
"type": "",
"text": [
"However, in brown fat, we observed a 2-3-fold increase in the expression of UCP1 in response to dietary fat challenge, which may be related to diet-induced elevations in plasma leptin levels"
],
"offsets": [
[
0,
190
... | [
{
"id": "IEPA.d63.s160.e0",
"type": "",
"text": [
"UCP1"
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76,
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},
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"id": "IEPA.d63.s160.e1",
"type": "",
"text": [
"leptin"
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177,
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]
... | [] | [] | [
{
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"arg2_id": "IEPA.d63.s160.e1",
"normalized": []
}
] |
IEPA.d65 | 9561804 | [
{
"id": "IEPA.d65.s163",
"type": "",
"text": [
"Vasopressin-induced activation of protein kinase C in renal epithelial cells"
],
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[
0,
76
]
]
},
{
"id": "IEPA.d65.s164",
"type": "",
"text": [
"AVP induced a biphasic increase... | [
{
"id": "IEPA.d65.s163.e0",
"type": "",
"text": [
"Vasopressin"
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0,
11
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],
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},
{
"id": "IEPA.d65.s163.e1",
"type": "",
"text": [
"protein kinase C"
],
"offsets": [
[
34,
... | [] | [] | [
{
"id": "IEPA.d65.s163.i0",
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},
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"arg2_id": "IEPA.d65.s164.e1",
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},
{
"id": "IEPA.... |
IEPA.d66 | 9575789 | [
{
"id": "IEPA.d66.s166",
"type": "",
"text": [
"However, the AVP-dependent stimulation required activation of protein kinase C (PKC), whereas the inhibition was PKC independent, indicating that the NGF-induced signaling pathways leading to inhibition and stimulation of HCO3- absorption are distinc... | [
{
"id": "IEPA.d66.s166.e0",
"type": "",
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"AVP"
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13,
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},
{
"id": "IEPA.d66.s166.e1",
"type": "",
"text": [
"protein kinase C"
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62,
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... | [] | [] | [
{
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"arg2_id": "IEPA.d66.s166.e1",
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}
] |
IEPA.d67 | 9593725 | [
{
"id": "IEPA.d67.s167",
"type": "",
"text": [
"Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin"
],
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[
0,
157
]
]
},
{
"id": "IE... | [
{
"id": "IEPA.d67.s167.e0",
"type": "",
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"phospholipase C-gamma"
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[
41,
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],
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},
{
"id": "IEPA.d67.s167.e1",
"type": "",
"text": [
"PLCgamma"
],
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115,
... | [] | [] | [
{
"id": "IEPA.d67.s167.i0",
"type": "PPI",
"arg1_id": "IEPA.d67.s167.e1",
"arg2_id": "IEPA.d67.s167.e2",
"normalized": []
}
] |
IEPA.d70 | 9633016 | [
{
"id": "IEPA.d70.s171",
"type": "",
"text": [
"Inhibition of 5-HT3 serotonergic receptors with ondansetron (4 or 8 mg) did not modify the basal secretion of AVP and OT and the OT response to insulin-induced hypoglycemia"
],
"offsets": [
[
0,
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]
]
}
] | [
{
"id": "IEPA.d70.s171.e0",
"type": "",
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"OT"
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118,
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},
{
"id": "IEPA.d70.s171.e1",
"type": "",
"text": [
"OT"
],
"offsets": [
[
129,
131
]
]... | [] | [] | [
{
"id": "IEPA.d70.s171.i0",
"type": "PPI",
"arg1_id": "IEPA.d70.s171.e1",
"arg2_id": "IEPA.d70.s171.e2",
"normalized": []
}
] |
IEPA.d71 | 9634587 | [
{
"id": "IEPA.d71.s172",
"type": "",
"text": [
"HvSPY coexpression largely abolished GA3-induced activity of an alpha-amylase promoter."
],
"offsets": [
[
0,
87
]
]
}
] | [
{
"id": "IEPA.d71.s172.e0",
"type": "",
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"GA3"
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[
37,
40
]
],
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},
{
"id": "IEPA.d71.s172.e1",
"type": "",
"text": [
"alpha-amylase"
],
"offsets": [
[
64,
77
... | [] | [] | [
{
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"type": "PPI",
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"arg2_id": "IEPA.d71.s172.e1",
"normalized": []
}
] |
IEPA.d72 | 9640660 | [
{
"id": "IEPA.d72.s173",
"type": "",
"text": [
"Treatment with (+)-trifluoro-ABA strongly inhibited the gibberellic acid-inducible expression of alpha-amylase I-1 encoded by RAmy1A in the aleurone layers of embryoless half-seeds at the levels of transcription, protein synthesis, and enzyme activit... | [
{
"id": "IEPA.d72.s173.e0",
"type": "",
"text": [
"gibberellic acid"
],
"offsets": [
[
56,
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],
"normalized": []
},
{
"id": "IEPA.d72.s173.e1",
"type": "",
"text": [
"alpha-amylase"
],
"offsets": [
[
97,
... | [] | [] | [
{
"id": "IEPA.d72.s173.i0",
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"arg1_id": "IEPA.d72.s173.e0",
"arg2_id": "IEPA.d72.s173.e1",
"normalized": []
}
] |
IEPA.d73 | 9642681 | [
{
"id": "IEPA.d73.s174",
"type": "",
"text": [
"Furthermore, treatment of isolated rat diaphragms and adipocytes with PIG-P as well as with other agents exerting partially insulin-mimetic activity, such as PI-specific phospholipase C (PLC) and the sulfonylurea glimepiride, triggered tyrosine phosp... | [
{
"id": "IEPA.d73.s174.e0",
"type": "",
"text": [
"insulin"
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[
124,
131
]
],
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},
{
"id": "IEPA.d73.s174.e1",
"type": "",
"text": [
"phospholipase C"
],
"offsets": [
[
170,
... | [] | [] | [] |
IEPA.d74 | 9648822 | [
{
"id": "IEPA.d74.s176",
"type": "",
"text": [
"Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins"
],
"offsets": [
[
0,
127
]
]
},
{
"id": "IEPA.d74.s177",
"type": "",
... | [
{
"id": "IEPA.d74.s176.e0",
"type": "",
"text": [
"leptin"
],
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[
16,
22
]
],
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},
{
"id": "IEPA.d74.s176.e1",
"type": "",
"text": [
"uncoupling proteins"
],
"offsets": [
[
108,
... | [] | [] | [
{
"id": "IEPA.d74.s176.i0",
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"arg2_id": "IEPA.d74.s177.e1",
"normalized": []
},
{
"id": "IEPA.... |
IEPA.d76 | 9660095 | [
{
"id": "IEPA.d76.s182",
"type": "",
"text": [
"Melatonin inhibits oxytocin response to insulin-induced hypoglycemia, but not to angiotensin II in normal men"
],
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[
0,
109
]
]
},
{
"id": "IEPA.d76.s183",
"type": "",
"text": [
... | [
{
"id": "IEPA.d76.s182.e0",
"type": "",
"text": [
"oxytocin"
],
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[
19,
27
]
],
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},
{
"id": "IEPA.d76.s182.e1",
"type": "",
"text": [
"insulin"
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[
40,
47
... | [] | [] | [
{
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},
{
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"type": "PPI",
"arg1_id": "IEPA.d76.s184.e0",
"arg2_id": "IEPA.d76.s184.e1",
"normalized": []
}
] |
IEPA.d77 | 9662044 | [
{
"id": "IEPA.d77.s185",
"type": "",
"text": [
"Although osmotic stimuli cause an increase in nitric oxide synthase (NOS) activity as well as synthesis of AVP and oxytocin in the paraventricular (PVN) and supraoptic nuclei (SON), it is not known whether NOS activity in the hypothalamus changes in ... | [
{
"id": "IEPA.d77.s185.e0",
"type": "",
"text": [
"oxytocin"
],
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[
115,
123
]
],
"normalized": []
},
{
"id": "IEPA.d77.s185.e1",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
334,
341
... | [] | [] | [
{
"id": "IEPA.d77.s186.i0",
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"arg1_id": "IEPA.d77.s186.e0",
"arg2_id": "IEPA.d77.s186.e1",
"normalized": []
}
] |
IEPA.d79 | 9673007 | [
{
"id": "IEPA.d79.s189",
"type": "",
"text": [
"OT evokes the release of Ca2+ from IP3-sensitive intracellular stores"
],
"offsets": [
[
0,
69
]
]
}
] | [
{
"id": "IEPA.d79.s189.e0",
"type": "",
"text": [
"OT"
],
"offsets": [
[
0,
2
]
],
"normalized": []
},
{
"id": "IEPA.d79.s189.e1",
"type": "",
"text": [
"IP3"
],
"offsets": [
[
35,
38
]
],
... | [] | [] | [] |
IEPA.d80 | 9682828 | [
{
"id": "IEPA.d80.s190",
"type": "",
"text": [
"To explore the possible roles of the hypothalamic melanocortin system in leptin action, we examined the effects of intracerebroventricular (i.c.v.) injection of leptin with or without SHU9119, a potent antagonist of alpha-melanocyte stimulating hormo... | [
{
"id": "IEPA.d80.s190.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
73,
79
]
],
"normalized": []
},
{
"id": "IEPA.d80.s190.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
161,
167
]... | [] | [] | [
{
"id": "IEPA.d80.s191.i0",
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},
{
"id": "IEPA.d80.s192.i0",
"type": "PPI",
"arg1_id": "IEPA.d80.s192.e0",
"arg2_id": "IEPA.d80.s192.e1",
"normalized": []
}
] |
IEPA.d81 | 9685679 | [
{
"id": "IEPA.d81.s193",
"type": "",
"text": [
"It has been established that amyloid beta peptide (AbetaP) activates phospholipase A2, phospholipase C and phospholipase D of LA-N-2 cells and other cell types"
],
"offsets": [
[
0,
159
]
]
},
{
"id": "... | [
{
"id": "IEPA.d81.s193.e0",
"type": "",
"text": [
"amyloid"
],
"offsets": [
[
29,
36
]
],
"normalized": []
},
{
"id": "IEPA.d81.s193.e1",
"type": "",
"text": [
"phospholipase C"
],
"offsets": [
[
87,
10... | [] | [] | [
{
"id": "IEPA.d81.s193.i0",
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"arg1_id": "IEPA.d81.s194.e0",
"arg2_id": "IEPA.d81.s194.e1",
"normalized": []
}
] |
IEPA.d82 | 9688683 | [
{
"id": "IEPA.d82.s195",
"type": "",
"text": [
"Neural site of leptin influence on neuropeptide Y signaling pathways altering feeding and uncoupling protein"
],
"offsets": [
[
0,
108
]
]
},
{
"id": "IEPA.d82.s196",
"type": "",
"text": [
... | [
{
"id": "IEPA.d82.s195.e0",
"type": "",
"text": [
"leptin"
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"offsets": [
[
15,
21
]
],
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},
{
"id": "IEPA.d82.s195.e1",
"type": "",
"text": [
"uncoupling protein"
],
"offsets": [
[
90,
... | [] | [] | [
{
"id": "IEPA.d82.s195.i0",
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},
{
"id": "IEPA.d82.s197.i0",
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"arg1_id": "IEPA.d82.s197.e0",
"arg2_id": "IEPA.d82.s197.e1",
"normalized": []
}
] |
IEPA.d83 | 9689469 | [
{
"id": "IEPA.d83.s198",
"type": "",
"text": [
"Furthermore, immunocytochemical studies showed the A beta-induced neuronal MAC expression on the SH-SY5Y cells after CD59 was removed by PIPLC or blocked by anti-CD59 antibody"
],
"offsets": [
[
0,
175
]
]
}
... | [
{
"id": "IEPA.d83.s198.e0",
"type": "",
"text": [
"A beta"
],
"offsets": [
[
51,
57
]
],
"normalized": []
},
{
"id": "IEPA.d83.s198.e1",
"type": "",
"text": [
"PIPLC"
],
"offsets": [
[
137,
142
]
... | [] | [] | [] |
IEPA.d84 | 9698023 | [
{
"id": "IEPA.d84.s199",
"type": "",
"text": [
"Effect of residual endogenous insulin secretion on the abnormal oxytocin response to hypoglycaemia in insulin-dependent diabetics"
],
"offsets": [
[
0,
129
]
]
},
{
"id": "IEPA.d84.s200",
"type": ""... | [
{
"id": "IEPA.d84.s199.e0",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
30,
37
]
],
"normalized": []
},
{
"id": "IEPA.d84.s199.e1",
"type": "",
"text": [
"oxytocin"
],
"offsets": [
[
64,
72
... | [] | [] | [
{
"id": "IEPA.d84.s199.i0",
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},
{
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"arg1_id": "IEPA.d84.s200.e0",
"arg2_id": "IEPA.d84.s200.e1",
"normalized": []
},
{
"id": "IEPA.... |
IEPA.d85 | 9722564 | [
{
"id": "IEPA.d85.s204",
"type": "",
"text": [
"A barley gene encoding a novel DNA-binding protein (HRT) was identified by southwestern screening with baits containing a gibberellin phytohormone response element from an alpha-amylase promoter"
],
"offsets": [
[
0,
194... | [
{
"id": "IEPA.d85.s204.e0",
"type": "",
"text": [
"gibberellin"
],
"offsets": [
[
122,
133
]
],
"normalized": []
},
{
"id": "IEPA.d85.s204.e1",
"type": "",
"text": [
"alpha-amylase"
],
"offsets": [
[
172,
... | [] | [] | [
{
"id": "IEPA.d85.s204.i0",
"type": "PPI",
"arg1_id": "IEPA.d85.s204.e0",
"arg2_id": "IEPA.d85.s204.e1",
"normalized": []
}
] |
IEPA.d86 | 9777024 | [
{
"id": "IEPA.d86.s205",
"type": "",
"text": [
"These observations suggest that bradykinin, like oxytocin, activates phospholipase C which generates IP3 with a subsequent release of Ca2+ from intracellular stores followed by store-operated Ca2+ influx"
],
"offsets": [
[
0,
... | [
{
"id": "IEPA.d86.s205.e0",
"type": "",
"text": [
"oxytocin"
],
"offsets": [
[
49,
57
]
],
"normalized": []
},
{
"id": "IEPA.d86.s205.e1",
"type": "",
"text": [
"IP3"
],
"offsets": [
[
101,
104
]
... | [] | [] | [
{
"id": "IEPA.d86.s205.i0",
"type": "PPI",
"arg1_id": "IEPA.d86.s205.e0",
"arg2_id": "IEPA.d86.s205.e1",
"normalized": []
}
] |
IEPA.d87 | 9792538 | [
{
"id": "IEPA.d87.s206",
"type": "",
"text": [
"These findings led us to conclude that inositol trisphosphate [corrected] causes Ca2+ mobilization by muscarinic activation of PLC, leading to intracellular translocation of insulin granules to the ready-releasable pool in pancreatic beta-cells via C... | [
{
"id": "IEPA.d87.s206.e0",
"type": "",
"text": [
"PLC"
],
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[
127,
130
]
],
"normalized": []
},
{
"id": "IEPA.d87.s206.e1",
"type": "",
"text": [
"insulin"
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[
174,
181
]... | [] | [] | [
{
"id": "IEPA.d87.s206.i0",
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"arg2_id": "IEPA.d87.s206.e1",
"normalized": []
}
] |
IEPA.d88 | 9792555 | [
{
"id": "IEPA.d88.s207",
"type": "",
"text": [
"To elucidate the pathophysiologic significance of UCP3 and UCP2 in the effect of TZDs on glucose metabolism and energy expenditure, we examined their basal mRNA levels in the WAT, brown adipose tissue (BAT), and skeletal muscle from Wistar fatty rats... | [
{
"id": "IEPA.d88.s207.e0",
"type": "",
"text": [
"UCP3"
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50,
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]
],
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},
{
"id": "IEPA.d88.s207.e1",
"type": "",
"text": [
"UCP2"
],
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[
59,
63
]
]... | [] | [] | [] |
IEPA.d89 | 9795377 | [
{
"id": "IEPA.d89.s209",
"type": "",
"text": [
"UCP2, UCP3 and leptin gene expression: modulation by food restriction and leptin"
],
"offsets": [
[
0,
80
]
]
},
{
"id": "IEPA.d89.s210",
"type": "",
"text": [
"To determine the effects of... | [
{
"id": "IEPA.d89.s209.e0",
"type": "",
"text": [
"UCP2"
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[
0,
4
]
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},
{
"id": "IEPA.d89.s209.e1",
"type": "",
"text": [
"UCP3"
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[
6,
10
]
],
... | [] | [] | [
{
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"arg2_id": "IEPA.d89.s209.e3",
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},
{
"id": "IEPA.... |
IEPA.d90 | 9862499 | [
{
"id": "IEPA.d90.s213",
"type": "",
"text": [
"DNase1 footprints suggest the involvement of at least three types of transcription factors in the regulation of alpha-Amy2/A by gibberellin"
],
"offsets": [
[
0,
139
]
]
},
{
"id": "IEPA.d90.s214",
... | [
{
"id": "IEPA.d90.s213.e0",
"type": "",
"text": [
"alpha-Amy2/A"
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[
112,
124
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],
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},
{
"id": "IEPA.d90.s213.e1",
"type": "",
"text": [
"gibberellin"
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[
128,
... | [] | [] | [
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"arg2_id": "IEPA.d90.s214.e1",
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}
] |
IEPA.d91 | 9863156 | [
{
"id": "IEPA.d91.s215",
"type": "",
"text": [
"Oxytocin-stimulated insulin release in a clonal beta-cell line RINm5F: involvement of phospholipase C-dependent and -independent pathways."
],
"offsets": [
[
0,
138
]
]
},
{
"id": "IEPA.d91.s216",
"... | [
{
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"type": "",
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"insulin"
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20,
27
]
],
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},
{
"id": "IEPA.d91.s215.e1",
"type": "",
"text": [
"phospholipase C"
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86,
10... | [] | [] | [
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},
{
"id": "IEPA.... |
IEPA.d92 | 9867073 | [
{
"id": "IEPA.d92.s225",
"type": "",
"text": [
"In isolated adipocytes, the loss of almost half the 18S RNA content over a 24-hour incubation was prevented in the presence of insulin but not oxytocin or epidermal growth factor (EGF)"
],
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0,
184
]
... | [
{
"id": "IEPA.d92.s225.e0",
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127,
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{
"id": "IEPA.d92.s225.e1",
"type": "",
"text": [
"oxytocin"
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[
143,
151
... | [] | [] | [] |
IEPA.d93 | 9870709 | [
{
"id": "IEPA.d93.s226",
"type": "",
"text": [
"Further investigation suggested that activation of protein kinase C (PKC), which is part of the AVP-induced intracellular signalling pathway, is necessary and sufficient for the generation of the synergistic response, although it is not obligatory fo... | [
{
"id": "IEPA.d93.s226.e0",
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51,
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},
{
"id": "IEPA.d93.s226.e1",
"type": "",
"text": [
"AVP"
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[
96,
99
... | [] | [] | [
{
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"arg2_id": "IEPA.d93.s226.e1",
"normalized": []
}
] |
IEPA.d94 | 9876242 | [
{
"id": "IEPA.d94.s227",
"type": "",
"text": [
"Oxytocin (OT) is more expressed in the TEC/TNC than vasopressin (VP); insulin-like growth factor 2 (IGF-2) thymic expression predominates over IGF-1, and much more over (pro)insulin"
],
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0,
181
]
... | [
{
"id": "IEPA.d94.s227.e0",
"type": "",
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0,
8
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],
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},
{
"id": "IEPA.d94.s227.e1",
"type": "",
"text": [
"(pro)insulin"
],
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[
169,
181
... | [] | [] | [] |
IEPA.d96 | 9892233 | [
{
"id": "IEPA.d96.s231",
"type": "",
"text": [
"Downregulation of uncoupling protein 2 mRNA in white adipose tissue and uncoupling protein 3 mRNA in skeletal muscle during the early stages of leptin treatment"
],
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[
0,
160
]
]
},
{
"id": ... | [
{
"id": "IEPA.d96.s231.e0",
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"uncoupling protein 2"
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18,
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],
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},
{
"id": "IEPA.d96.s231.e1",
"type": "",
"text": [
"uncoupling protein 3"
],
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[
... | [] | [] | [
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},
{
"id": "IEPA.... |
IEPA.d97 | 9893131 | [
{
"id": "IEPA.d97.s234",
"type": "",
"text": [
"The specific protein kinase C (PKC) inhibitor chelerythrine (5 micrometers) inhibited PTH-, AVP-, PGE2-, and adenosine-stimulated Ca2+ reabsorption by 77%, 67%, 79%, and 100%, respectively"
],
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[
0,
188
... | [
{
"id": "IEPA.d97.s234.e0",
"type": "",
"text": [
"protein kinase C"
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[
13,
29
]
],
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},
{
"id": "IEPA.d97.s234.e1",
"type": "",
"text": [
"AVP"
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[
92,
95
... | [] | [] | [
{
"id": "IEPA.d97.s234.i0",
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},
{
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"arg1_id": "IEPA.d97.s235.e0",
"arg2_id": "IEPA.d97.s235.e1",
"normalized": []
}
] |
IEPA.d98 | 9920656 | [
{
"id": "IEPA.d98.s236",
"type": "",
"text": [
"We observed that primary microglial cultures and the THP-1 monocytic cell line are stimulated by fibrillar beta-amyloid and prion peptides to activate identical tyrosine kinase-dependent inflammatory signal transduction cascades"
],
"offsets"... | [
{
"id": "IEPA.d98.s236.e0",
"type": "",
"text": [
"prion"
],
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[
124,
129
]
],
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},
{
"id": "IEPA.d98.s236.e1",
"type": "",
"text": [
"tyrosine kinase"
],
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[
161,
1... | [] | [] | [
{
"id": "IEPA.d98.s236.i0",
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"arg1_id": "IEPA.d98.s236.e0",
"arg2_id": "IEPA.d98.s236.e1",
"normalized": []
}
] |
IEPA.d99 | 9920735 | [
{
"id": "IEPA.d99.s237",
"type": "",
"text": [
"Enhanced phosphoinositide hydrolysis via overexpression of phospholipase C beta1 or delta1 inhibits stimulus-induced insulin release in insulinoma MIN6 cells."
],
"offsets": [
[
0,
158
]
]
},
{
"id": "I... | [
{
"id": "IEPA.d99.s237.e0",
"type": "",
"text": [
"phospholipase C"
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[
59,
74
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},
{
"id": "IEPA.d99.s237.e1",
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117,
1... | [] | [] | [
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}
] |
IEPA.d100 | 9924739 | [
{
"id": "IEPA.d100.s239",
"type": "",
"text": [
"If daily oxytocin injections are repeated over a 5-day period, blood pressure is decreased by 10-20 mmHg, the withdrawal latency to heat stimuli is prolonged, cortisol levels are decreased and insulin and cholecystokinin levels are increased"
],... | [
{
"id": "IEPA.d100.s239.e0",
"type": "",
"text": [
"oxytocin"
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9,
17
]
],
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},
{
"id": "IEPA.d100.s239.e1",
"type": "",
"text": [
"insulin"
],
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[
193,
200
... | [] | [] | [
{
"id": "IEPA.d100.s239.i0",
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"arg1_id": "IEPA.d100.s239.e0",
"arg2_id": "IEPA.d100.s239.e1",
"normalized": []
}
] |
IEPA.d104 | 10066625 | [
{
"id": "IEPA.d104.s243",
"type": "",
"text": [
"In addition, abscisic acid-mediated inhibition of gibberellin-stimulated responses seems to depend on the activation of a phospholipase D during induction of alpha-amylase in barley aleurone cells as well as on a putative acetyltransferase involved ... | [
{
"id": "IEPA.d104.s243.e0",
"type": "",
"text": [
"gibberellin"
],
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[
50,
61
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],
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},
{
"id": "IEPA.d104.s243.e1",
"type": "",
"text": [
"alpha-amylase"
],
"offsets": [
[
158,
... | [] | [] | [] |
IEPA.d106 | 10070167 | [
{
"id": "IEPA.d106.s245",
"type": "",
"text": [
"Protein kinase C (PKC) inhibitors reversed AVP inhibition, whereas PKC activator inhibited nitrite production"
],
"offsets": [
[
0,
109
]
]
},
{
"id": "IEPA.d106.s246",
"type": "",
"text": [
... | [
{
"id": "IEPA.d106.s245.e0",
"type": "",
"text": [
"Protein kinase C"
],
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[
0,
16
]
],
"normalized": []
},
{
"id": "IEPA.d106.s245.e1",
"type": "",
"text": [
"AVP"
],
"offsets": [
[
43,
46
... | [] | [] | [
{
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"arg1_id": "IEPA.d106.s246.e0",
"arg2_id": "IEPA.d106.s246.e1",
"normalized": []
}
] |
IEPA.d107 | 10080713 | [
{
"id": "IEPA.d107.s247",
"type": "",
"text": [
"Molecular characterization of catalytic-subunit cDNA sequences encoding protein phosphatases 1 and 2A and study of their roles in the gibberellin-dependent Osamy-c expression in rice"
],
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[
0,
182
]
... | [
{
"id": "IEPA.d107.s247.e0",
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[
134,
145
]
],
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},
{
"id": "IEPA.d107.s247.e1",
"type": "",
"text": [
"Osamy-c"
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[
156,
1... | [] | [] | [
{
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"arg2_id": "IEPA.d107.s248.e1",
"normalized": []
},
{
"id": ... |
IEPA.d109 | 10098482 | [
{
"id": "IEPA.d109.s256",
"type": "",
"text": [
"Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between messenger ribonucleic acid and protein expression"
],
"offsets": [
[
0,
142
]
]
},
{
"id": "IEPA.d109.s257",... | [
{
"id": "IEPA.d109.s256.e0",
"type": "",
"text": [
"leptin"
],
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[
12,
18
]
],
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},
{
"id": "IEPA.d109.s256.e1",
"type": "",
"text": [
"uncoupling protein"
],
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[
47,
... | [] | [] | [
{
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},
{
"id": "IEPA.d109.s259.i0",
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"arg2_id": "IEPA.d109.s259.e2",
"normalized": []
},
{
"id": ... |
IEPA.d111 | 10102788 | [
{
"id": "IEPA.d111.s269",
"type": "",
"text": [
"Plasma oxytocin, and some functionally related peptides (CCK, gastrin, somatostatin and insulin), were measured by standard radioimmunoassay techniques"
],
"offsets": [
[
0,
151
]
]
}
] | [
{
"id": "IEPA.d111.s269.e0",
"type": "",
"text": [
"oxytocin"
],
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[
7,
15
]
],
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},
{
"id": "IEPA.d111.s269.e1",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
88,
95
... | [] | [] | [] |
IEPA.d112 | 10198105 | [
{
"id": "IEPA.d112.s270",
"type": "",
"text": [
"Analyses of hormone regulation of expression of mRNA for the aleurone RNase revealed that, like the pattern for alpha-amylase, mRNA levels increased in the presence of gibberellic acid, and its antagonist abscisic acid prevented this effect"
],
... | [
{
"id": "IEPA.d112.s270.e0",
"type": "",
"text": [
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],
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[
112,
125
]
],
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},
{
"id": "IEPA.d112.s270.e1",
"type": "",
"text": [
"gibberellic acid"
],
"offsets": [
[
168... | [] | [] | [
{
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{
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"arg1_id": "IEPA.d112.s271.e0",
"arg2_id": "IEPA.d112.s271.e1",
"normalized": []
}
] |
IEPA.d113 | 10235637 | [
{
"id": "IEPA.d113.s272",
"type": "",
"text": [
"The experiments were concluded by taking blood samples for later analysis of plasma glucose and plasma levels of the following hormones: insulin, gastrin, CCK, glucagon, somatostatin, oxytocin and corticosterone"
],
"offsets": [
[
... | [
{
"id": "IEPA.d113.s272.e0",
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"insulin"
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137,
144
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],
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},
{
"id": "IEPA.d113.s272.e1",
"type": "",
"text": [
"oxytocin"
],
"offsets": [
[
184,
192
... | [] | [] | [] |
IEPA.d114 | 10331406 | [
{
"id": "IEPA.d114.s274",
"type": "",
"text": [
"In normal pancreatic islets, UCP-2 is upregulated by leptin and is low in leptin-resistant islets of ZDF rats"
],
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[
0,
109
]
]
},
{
"id": "IEPA.d114.s275",
"type": "",
"text": [
... | [
{
"id": "IEPA.d114.s274.e0",
"type": "",
"text": [
"UCP-2"
],
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[
29,
34
]
],
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},
{
"id": "IEPA.d114.s274.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
53,
59
]
... | [] | [] | [
{
"id": "IEPA.d114.s274.i0",
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"arg1_id": "IEPA.d114.s274.e0",
"arg2_id": "IEPA.d114.s274.e1",
"normalized": []
}
] |
IEPA.d117 | 10364415 | [
{
"id": "IEPA.d117.s285",
"type": "",
"text": [
"The second class of mutant, gse (GA sensitivity), differed principally in GA sensitivity, requiring approximately 100-fold higher [GA3] for both leaf elongation and alpha-amylase production by aleurone"
],
"offsets": [
[
0,
... | [
{
"id": "IEPA.d117.s285.e0",
"type": "",
"text": [
"GA"
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33,
35
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],
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},
{
"id": "IEPA.d117.s285.e1",
"type": "",
"text": [
"GA"
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[
74,
76
]
],
... | [] | [] | [
{
"id": "IEPA.d117.s285.i0",
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"arg1_id": "IEPA.d117.s285.e2",
"arg2_id": "IEPA.d117.s285.e3",
"normalized": []
}
] |
IEPA.d118 | 10375750 | [
{
"id": "IEPA.d118.s286",
"type": "",
"text": [
"Phorbol myristate acetate (TPA), an activator of PKC, elicited an increase of MAPK activity, but did not further influence the level of AVP4-8-enhanced MAPK activity; Nevertheless, the extent of CaMKII activation was attenuated by TPA"
],
"o... | [
{
"id": "IEPA.d118.s286.e0",
"type": "",
"text": [
"PKC"
],
"offsets": [
[
49,
52
]
],
"normalized": []
},
{
"id": "IEPA.d118.s286.e1",
"type": "",
"text": [
"AVP"
],
"offsets": [
[
136,
139
]
... | [] | [] | [] |
IEPA.d119 | 10394640 | [
{
"id": "IEPA.d119.s287",
"type": "",
"text": [
"The gibberellin-responsive elements conserved in cereal alpha-amylase genes are not included in the 5'-upstream region of Rep1 or RepA"
],
"offsets": [
[
0,
134
]
]
}
] | [
{
"id": "IEPA.d119.s287.e0",
"type": "",
"text": [
"gibberellin"
],
"offsets": [
[
4,
15
]
],
"normalized": []
},
{
"id": "IEPA.d119.s287.e1",
"type": "",
"text": [
"alpha-amylase"
],
"offsets": [
[
56,
... | [] | [] | [
{
"id": "IEPA.d119.s287.i0",
"type": "PPI",
"arg1_id": "IEPA.d119.s287.e0",
"arg2_id": "IEPA.d119.s287.e1",
"normalized": []
}
] |
IEPA.d120 | 10405973 | [
{
"id": "IEPA.d120.s288",
"type": "",
"text": [
"Furthermore, our 14C-acetate-labeling studies showed a 50% reduction in cholesteryl ester synthesis in the presence of either flavonoid, which could account for the reduction in net apoB secretion caused by incubation with these compounds"
],
... | [
{
"id": "IEPA.d120.s288.e0",
"type": "",
"text": [
"cholesteryl ester"
],
"offsets": [
[
72,
89
]
],
"normalized": []
},
{
"id": "IEPA.d120.s288.e1",
"type": "",
"text": [
"flavonoid"
],
"offsets": [
[
126,
... | [] | [] | [
{
"id": "IEPA.d120.s288.i0",
"type": "PPI",
"arg1_id": "IEPA.d120.s288.e0",
"arg2_id": "IEPA.d120.s288.e1",
"normalized": []
}
] |
IEPA.d121 | 10432317 | [
{
"id": "IEPA.d121.s289",
"type": "",
"text": [
"An inhibitor of PKC, Ro31-8220 (10 microM), abolished the ability of PDBu to decrease [Ca(2+)](i), without affecting the response to maximal or submaximal concentrations of AVP"
],
"offsets": [
[
0,
176
]
]
... | [
{
"id": "IEPA.d121.s289.e0",
"type": "",
"text": [
"PKC"
],
"offsets": [
[
16,
19
]
],
"normalized": []
},
{
"id": "IEPA.d121.s289.e1",
"type": "",
"text": [
"AVP"
],
"offsets": [
[
173,
176
]
... | [] | [] | [] |
IEPA.d122 | 10433228 | [
{
"id": "IEPA.d122.s290",
"type": "",
"text": [
"Effects of intravenously infused leptin on insulin sensitivity and on the expression of uncoupling proteins in brown adipose tissue"
],
"offsets": [
[
0,
131
]
]
},
{
"id": "IEPA.d122.s291",
"type"... | [
{
"id": "IEPA.d122.s290.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
33,
39
]
],
"normalized": []
},
{
"id": "IEPA.d122.s290.e1",
"type": "",
"text": [
"uncoupling proteins"
],
"offsets": [
[
88,
... | [] | [] | [
{
"id": "IEPA.d122.s290.i0",
"type": "PPI",
"arg1_id": "IEPA.d122.s290.e0",
"arg2_id": "IEPA.d122.s290.e1",
"normalized": []
},
{
"id": "IEPA.d122.s291.i0",
"type": "PPI",
"arg1_id": "IEPA.d122.s291.e0",
"arg2_id": "IEPA.d122.s291.e1",
"normalized": []
},
{
"id": ... |
IEPA.d126 | 10477827 | [
{
"id": "IEPA.d126.s299",
"type": "",
"text": [
"The expression of uterine UCP2 and UCP3 were up-regulated by 3.2- and 1.5-fold, respectively, during the late stage of pregnancy with an increase of WAT leptin mRNA expression and exogenous administration of leptin resulted in induction of the uteri... | [
{
"id": "IEPA.d126.s299.e0",
"type": "",
"text": [
"UCP2"
],
"offsets": [
[
26,
30
]
],
"normalized": []
},
{
"id": "IEPA.d126.s299.e1",
"type": "",
"text": [
"UCP3"
],
"offsets": [
[
35,
39
]
... | [] | [] | [
{
"id": "IEPA.d126.s299.i0",
"type": "PPI",
"arg1_id": "IEPA.d126.s299.e3",
"arg2_id": "IEPA.d126.s299.e4",
"normalized": []
},
{
"id": "IEPA.d126.s299.i1",
"type": "PPI",
"arg1_id": "IEPA.d126.s299.e3",
"arg2_id": "IEPA.d126.s299.e5",
"normalized": []
},
{
"id": ... |
IEPA.d127 | 10480887 | [
{
"id": "IEPA.d127.s301",
"type": "",
"text": [
"PI-PLC treatment of fetal guinea pig brain cultures substantially reduced the amount of Abeta40 and Abeta42 in the medium but had no effect on sAPPalpha"
],
"offsets": [
[
0,
152
]
]
},
{
"id": "IEPA.d... | [
{
"id": "IEPA.d127.s301.e0",
"type": "",
"text": [
"PI-PLC"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "IEPA.d127.s301.e1",
"type": "",
"text": [
"Abeta40"
],
"offsets": [
[
88,
95
]
... | [] | [] | [
{
"id": "IEPA.d127.s301.i0",
"type": "PPI",
"arg1_id": "IEPA.d127.s301.e0",
"arg2_id": "IEPA.d127.s301.e1",
"normalized": []
},
{
"id": "IEPA.d127.s301.i1",
"type": "PPI",
"arg1_id": "IEPA.d127.s301.e0",
"arg2_id": "IEPA.d127.s301.e2",
"normalized": []
},
{
"id": ... |
IEPA.d128 | 10492523 | [
{
"id": "IEPA.d128.s303",
"type": "",
"text": [
"A neurotoxic fragment of amyloid, Abeta 25-35, incubated in the presence of endogenous Ca2+, increased significantly the PI-PLC activity of normoxic brain"
],
"offsets": [
[
0,
154
]
]
},
{
"id": "IEPA... | [
{
"id": "IEPA.d128.s303.e0",
"type": "",
"text": [
"amyloid"
],
"offsets": [
[
25,
32
]
],
"normalized": []
},
{
"id": "IEPA.d128.s303.e1",
"type": "",
"text": [
"PI-PLC"
],
"offsets": [
[
121,
127
... | [] | [] | [
{
"id": "IEPA.d128.s303.i0",
"type": "PPI",
"arg1_id": "IEPA.d128.s303.e0",
"arg2_id": "IEPA.d128.s303.e1",
"normalized": []
},
{
"id": "IEPA.d128.s304.i0",
"type": "PPI",
"arg1_id": "IEPA.d128.s304.e0",
"arg2_id": "IEPA.d128.s304.e1",
"normalized": []
},
{
"id": ... |
IEPA.d129 | 10516126 | [
{
"id": "IEPA.d129.s307",
"type": "",
"text": [
"Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats"
],
"offsets": [
[
0,
96
]
]
},
{
"id": "IEPA.d129.s308",
"type": "",
"text": [
"To furthe... | [
{
"id": "IEPA.d129.s307.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
24,
30
]
],
"normalized": []
},
{
"id": "IEPA.d129.s307.e1",
"type": "",
"text": [
"uncoupling protein"
],
"offsets": [
[
36,
... | [] | [] | [] |
IEPA.d130 | 10527454 | [
{
"id": "IEPA.d130.s312",
"type": "",
"text": [
"Amyloid beta peptide 25-35 modulates hydrolysis of phosphoinositides by membrane phospholipase(s) C of adult brain cortex"
],
"offsets": [
[
0,
121
]
]
},
{
"id": "IEPA.d130.s313",
"type": "",
... | [
{
"id": "IEPA.d130.s312.e0",
"type": "",
"text": [
"Amyloid"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "IEPA.d130.s312.e1",
"type": "",
"text": [
"phospholipase(s) C"
],
"offsets": [
[
81,
... | [] | [] | [
{
"id": "IEPA.d130.s312.i0",
"type": "PPI",
"arg1_id": "IEPA.d130.s312.e0",
"arg2_id": "IEPA.d130.s312.e1",
"normalized": []
},
{
"id": "IEPA.d130.s313.i0",
"type": "PPI",
"arg1_id": "IEPA.d130.s313.e0",
"arg2_id": "IEPA.d130.s313.e1",
"normalized": []
},
{
"id": ... |
IEPA.d131 | 10562440 | [
{
"id": "IEPA.d131.s316",
"type": "",
"text": [
"Vasopressin stimulates tyrosine phosphorylation by activation of PKC in the rat smooth muscle cell line, A-10"
],
"offsets": [
[
0,
109
]
]
},
{
"id": "IEPA.d131.s317",
"type": "",
"text": [
... | [
{
"id": "IEPA.d131.s316.e0",
"type": "",
"text": [
"Vasopressin"
],
"offsets": [
[
0,
11
]
],
"normalized": []
},
{
"id": "IEPA.d131.s316.e1",
"type": "",
"text": [
"PKC"
],
"offsets": [
[
65,
68
... | [] | [] | [
{
"id": "IEPA.d131.s316.i0",
"type": "PPI",
"arg1_id": "IEPA.d131.s316.e0",
"arg2_id": "IEPA.d131.s316.e1",
"normalized": []
},
{
"id": "IEPA.d131.s317.i0",
"type": "PPI",
"arg1_id": "IEPA.d131.s317.e0",
"arg2_id": "IEPA.d131.s317.e1",
"normalized": []
},
{
"id": ... |
End of preview. Expand
in Data Studio
Dataset Card for IEPA
The IEPA benchmark PPI corpus is designed for relation extraction. It was created from 303 PubMed abstracts, each of which contains a specific pair of co-occurring chemicals.
Citation Information
@ARTICLE{ding2001mining,
title = "Mining {MEDLINE}: abstracts, sentences, or phrases?",
author = "Ding, J and Berleant, D and Nettleton, D and Wurtele, E",
journal = "Pac Symp Biocomput",
pages = "326--337",
year = 2002,
address = "United States",
language = "en"
}
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