id stringlengths 1 3 | document_id stringlengths 11 13 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
0 | PMID-12484699 | [
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"Regulation of transforming growth factor-beta signaling and vascular diseases.\n\nPURPOSE: Members of the transforming growth factor (TGF)-beta superfamily play critical roles in regulation of various cellular functions. Dysregulation o... | [
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1 | PMID-16268479 | [
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"Domain 5 of cleaved high molecular weight kininogen inhibits endothelial cell migration through Akt.\n\nDomain 5 (D5) of cleaved high molecular weight kininogen (HKa) inhibits angiogenesis in vivo and endothelial cell migration in vitro... | [
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2 | PMID-11121230 | [
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"RNA damage and inhibition of neoplastic endothelial cell growth: effects of human and amphibian ribonucleases.\n\nAngiogenesis defines the many steps involved in the growth and migration of endothelial cell-derived blood vessels. This p... | [
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3 | PMID-12610665 | [
{
"id": "PMID-12610665__text",
"type": "abstract",
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"Arteriogenesis: the development and growth of collateral arteries.\n\nIn patients with atherosclerotic vascular diseases, collateral vessels bypassing major arterial obstructions have frequently been observed. This may explain why some ... | [
{
"id": "PMID-12610665_T2",
"type": "Multi-tissue_structure",
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"id": "PMID-12610665_T3",
"type": "Multi-tissue_structure",
"text": [
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"ref_id": "PMID-12610665_T11"
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... | [] | [] |
4 | PMID-17462601 | [
{
"id": "PMID-17462601__text",
"type": "abstract",
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"An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody.\n\nPlatelet-derived growth factor (PDGF) and its receptors (PDGFR) play important roles in tu... | [
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"type": "Gene_or_gene_product",
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... | [
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5 | PMID-19369582 | [
{
"id": "PMID-19369582__text",
"type": "abstract",
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"Characterization of the metabolic changes underlying growth factor angiogenic activation: identification of new potential therapeutic targets.\n\nAngiogenesis is a fundamental process to normal and abnormal tissue growth and repair, whi... | [
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... | [] |
6 | PMID-10589785 | [
{
"id": "PMID-10589785__text",
"type": "abstract",
"text": [
"The antiangiogenic agent linomide inhibits the growth rate of von Hippel-Lindau paraganglioma xenografts to mice.\n\nThe aim of this study was to ascertain the potential usefulness of the antiangiogenic compound linomide for treatment o... | [
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"role": "Theme",
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... | [] | [] |
7 | PMID-12140030 | [
{
"id": "PMID-12140030__text",
"type": "abstract",
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"Optimizing treatment of choroidal neovascularization feeder vessels associated with age-related macular degeneration.\n\nPURPOSE: To optimize the method of treating choroidal neovascularization (CNV) associated with age-related macular ... | [
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... | [
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8 | PMID-11238633 | [
{
"id": "PMID-11238633__text",
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"IL-12 inhibition of endothelial cell functions and angiogenesis depends on lymphocyte-endothelial cell cross-talk.\n\nIn vivo IL-12-dependent tumor inhibition rests on the ability of IL-12 to activate a CD8-mediated cytotoxicity, inhibi... | [
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[
... | [
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9 | PMID-16310808 | [
{
"id": "PMID-16310808__text",
"type": "abstract",
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"Effect of thalidomide affecting VEGF secretion, cell migration, adhesion and capillary tube formation of human endothelial EA.hy 926 cells.\n\nAngiogenesis, new blood vessel formation, is a multistep process, precisely regulated by pro-... | [
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"VEGF"
],
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... | [
{
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"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16310808_T4"
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... | [
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10 | PMID-15725689 | [
{
"id": "PMID-15725689__text",
"type": "abstract",
"text": [
"Role of thrombogenic factors in the development of atherosclerosis.\n\nHemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute ... | [
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"text": [
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"role": "Cause",
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... | [
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11 | PMID-10771470 | [
{
"id": "PMID-10771470__text",
"type": "abstract",
"text": [
"Active hair growth (anagen) is associated with angiogenesis.\n\nAfter the completion of skin development, angiogenesis, i.e., the growth of new capillaries from pre-existing blood vessels, is held to occur in the skin only under patholo... | [
{
"id": "PMID-10771470_T2",
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"id": "PMID-10771470_T3",
"type": "Tissue",
"text": [
"capillaries"
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[
... | [
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"arguments": [
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{
"id": ... | [] | [] |
12 | PMID-18835936 | [
{
"id": "PMID-18835936__text",
"type": "abstract",
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"Angiogenesis associated with visceral and subcutaneous adipose tissue in severe human obesity.\n\nOBJECTIVE: The expansion of adipose tissue is linked to the development of its vasculature. However, the regulation of adipose tissue angi... | [
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"id": "PMID-18835936_T3",
"type": "Tissue",
"text": [
"subcutaneous adipose tissue"
],
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... | [
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"id": "PMID-18835936_E1",
"type": "Development",
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"text": [
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"arguments": [
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"role": "Theme",
"ref_id": "PMID-18835936_T4"
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... | [
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}
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13 | PMID-12823209 | [
{
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"type": "abstract",
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"Prognostic value of p53 protein expression and vascular endothelial growth factor expression in resected squamous cell carcinoma of the esophagus.\n\nThe most common genetic alterations found in a wide variety of cancers are p53 tumor s... | [
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14 | PMID-10487573 | [
{
"id": "PMID-10487573__text",
"type": "abstract",
"text": [
"External beam radiotherapy for subretinal neovascularization in age-related macular degeneration: is this treatment efficient?\n\nPURPOSE: Control of the natural course of subretinal neovascularization (SRNV) in age-related macular dege... | [
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"macular"
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222,
... | [
{
"id": "PMID-10487573_E3",
"type": "Breakdown",
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"arguments": [
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"role": "Theme",
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... | [] | [] |
15 | PMID-10978899 | [
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"text": [
"Urokinase receptor: a molecular organizer in cellular communication.\n\nIn a variety of cell types, the glycolipid-anchored urokinase receptor (uPAR) is colocalized pericellularly with components of the plasminogen activation system and... | [
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"type": "Gene_or_gene_product",
"text": [
"glycolipid-anchored u... | [
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"type": "Gene_expression",
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... | [
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16 | PMID-16398404 | [
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"The differential regulation of human telomerase reverse transcriptase and vascular endothelial growth factor may contribute to the clinically more aggressive behavior of p63-positive breast carcinomas.\n\np63, a p53 homologue, is a myoe... | [
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"type": "Gene_or_gene_product",
"text": [
"vascul... | [
{
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"type": "Regulation",
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"arguments": [
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... | [
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... | [] |
17 | PMID-19236257 | [
{
"id": "PMID-19236257__text",
"type": "abstract",
"text": [
"Aflibercept (AVE0005): an alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors.\n\nBACKGROUND: Aberrant angiogenesis is a landmark feature in cancer, which is important for proliferation, growth... | [
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"id": "PMID-19236257_T2",
"type": "Drug_or_compound",
"text": [
"AVE0005"
],
"offsets": [
... | [
{
"id": "PMID-19236257_E14",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibit"
],
"offsets": [
[
489,
496
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19236257_E15"
},
... | [
{
"id": "PMID-19236257_1",
"entity_ids": [
"PMID-19236257_T1",
"PMID-19236257_T2"
]
}
] | [
{
"id": "PMID-19236257_R1",
"type": "frag",
"arg1_id": "PMID-19236257_T19",
"arg2_id": "PMID-19236257_T20",
"normalized": []
}
] |
18 | PMID-17960624 | [
{
"id": "PMID-17960624__text",
"type": "abstract",
"text": [
"Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-37 increases ovarian cancer cell proliferation and invasion.\n\nThe role of the pro-inflammatory peptide, LL-37, and its pro-form, human cationic antimi... | [
{
"id": "PMID-17960624_T2",
"type": "Gene_or_gene_product",
"text": [
"hCAP-18"
],
"offsets": [
[
54,
61
]
],
"normalized": []
},
{
"id": "PMID-17960624_T3",
"type": "Gene_or_gene_product",
"text": [
"LL-37"
],
"offsets": [
... | [
{
"id": "PMID-17960624_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"overexpress"
],
"offsets": [
[
16,
27
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-17960624_T2"
}
]
},
... | [
{
"id": "PMID-17960624_1",
"entity_ids": [
"PMID-17960624_T8",
"PMID-17960624_T9"
]
}
] | [
{
"id": "PMID-17960624_R1",
"type": "frag",
"arg1_id": "PMID-17960624_T30",
"arg2_id": "PMID-17960624_T31",
"normalized": []
},
{
"id": "PMID-17960624_R2",
"type": "frag",
"arg1_id": "PMID-17960624_T24",
"arg2_id": "PMID-17960624_T25",
"normalized": []
}
] |
19 | PMID-2418866 | [
{
"id": "PMID-2418866__text",
"type": "abstract",
"text": [
"Retinal revascularisation in diabetic retinopathy.\n\nThe case history of a 33-year-old diabetic patient who has had diabetes for 24 years is presented. When first seen in 1975 he had bilateral proliferative retinopathy with new vessels ... | [
{
"id": "PMID-2418866_T2",
"type": "Multi-tissue_structure",
"text": [
"vessels"
],
"offsets": [
[
227,
234
]
],
"normalized": []
},
{
"id": "PMID-2418866_T3",
"type": "Tissue",
"text": [
"capillary"
],
"offsets": [
[
... | [
{
"id": "PMID-2418866_E1",
"type": "Development",
"trigger": {
"text": [
"appearance"
],
"offsets": [
[
571,
581
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-2418866_T9"
}
]
},
{
... | [] | [] |
20 | PMID-16893130 | [
{
"id": "PMID-16893130__text",
"type": "abstract",
"text": [
"[Autologous bone marrow stem cell or peripheral blood endothelial progenitor cell therapy in patients with peripheral limb ischaemia]\n\nNo effective medical therapies have been developed sofar to enhance blood flow in the legs of patie... | [
{
"id": "PMID-16893130_T1",
"type": "Cell",
"text": [
"bone marrow stem cell"
],
"offsets": [
[
12,
33
]
],
"normalized": []
},
{
"id": "PMID-16893130_T3",
"type": "Cell",
"text": [
"peripheral blood endothelial progenitor cell"
... | [
{
"id": "PMID-16893130_E14",
"type": "Development",
"trigger": {
"text": [
"development"
],
"offsets": [
[
540,
551
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16893130_T15"
}
]
},
... | [] | [] |
21 | PMID-19050907 | [
{
"id": "PMID-19050907__text",
"type": "abstract",
"text": [
"Evaluation of electrical stimulation for ischemic wound therapy: a feasibility study using the lapine wound model.\n\nChronic wounds are a major secondary complication for many people with impaired mobility. Electrical stimulation (ES) ... | [
{
"id": "PMID-19050907_T2",
"type": "Gene_or_gene_product",
"text": [
"alpha2 (I) collagen"
],
"offsets": [
[
1162,
1181
]
],
"normalized": []
},
{
"id": "PMID-19050907_T3",
"type": "Gene_or_gene_product",
"text": [
"COL-I"
],
... | [
{
"id": "PMID-19050907_E10",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
1293,
1303
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19050907_T11"
}
]
... | [
{
"id": "PMID-19050907_1",
"entity_ids": [
"PMID-19050907_T2",
"PMID-19050907_T3"
]
},
{
"id": "PMID-19050907_2",
"entity_ids": [
"PMID-19050907_T5",
"PMID-19050907_T6"
]
},
{
"id": "PMID-19050907_3",
"entity_ids": [
"PMID-19050907_T8",
"PM... | [] |
22 | PMID-12724285 | [
{
"id": "PMID-12724285__text",
"type": "abstract",
"text": [
"Possible role of cyclooxygenase II in the acquisition of ovarian luteal function in rodents.\n\nThe development of the corpus luteum (CL), which involves angiogenesis, is essential for the establishment of early pregnancy. We investigat... | [
{
"id": "PMID-12724285_T1",
"type": "Gene_or_gene_product",
"text": [
"cyclooxygenase II"
],
"offsets": [
[
17,
34
]
],
"normalized": []
},
{
"id": "PMID-12724285_T2",
"type": "Multi-tissue_structure",
"text": [
"ovarian luteal"
... | [
{
"id": "PMID-12724285_E3",
"type": "Development",
"trigger": {
"text": [
"development"
],
"offsets": [
[
98,
109
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12724285_T4"
}
]
},
{... | [
{
"id": "PMID-12724285_1",
"entity_ids": [
"PMID-12724285_T4",
"PMID-12724285_T5"
]
}
] | [] |
23 | PMID-19605361 | [
{
"id": "PMID-19605361__text",
"type": "abstract",
"text": [
"MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover.\n\nThe formation of new blood vessels from pre-existing ones requires highly coordinated restructuring of endothelial cells (EC) and the surrounding ex... | [
{
"id": "PMID-19605361_T2",
"type": "Gene_or_gene_product",
"text": [
"MEK5"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "PMID-19605361_T3",
"type": "Gene_or_gene_product",
"text": [
"ERK5"
],
"offsets": [
... | [
{
"id": "PMID-19605361_E5",
"type": "Localization",
"trigger": {
"text": [
"migration"
],
"offsets": [
[
47,
56
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19605361_T6"
}
]
},
{
... | [
{
"id": "PMID-19605361_1",
"entity_ids": [
"PMID-19605361_T9",
"PMID-19605361_T10"
]
}
] | [] |
24 | PMID-3985123 | [
{
"id": "PMID-3985123__text",
"type": "abstract",
"text": [
"Mast cells and tumors. The specific enhancement of tumor proliferation in vitro.\n\nMast cells were found to be unique among the peritoneal leukocytes by virtue of their capacity to enhance profoundly the proliferation of a variety of tu... | [
{
"id": "PMID-3985123_T1",
"type": "Cell",
"text": [
"Mast cells"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "PMID-3985123_T2",
"type": "Pathological_formation",
"text": [
"tumors"
],
"offsets": [
[
... | [
{
"id": "PMID-3985123_E16",
"type": "Positive_regulation",
"trigger": {
"text": [
"enhance"
],
"offsets": [
[
596,
603
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-3985123_E17"
}
]
}... | [] | [] |
25 | PMID-16720995 | [
{
"id": "PMID-16720995__text",
"type": "abstract",
"text": [
"GDP and AGE receptors: mechanisms of peritoneal damage.\n\nLong-term peritoneal dialysis (PD) is limited by morphological changes of the peritoneal membrane. Structural changes were promoted by toxicity of glucose degradation products (... | [
{
"id": "PMID-16720995_T1",
"type": "Drug_or_compound",
"text": [
"GDP"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "PMID-16720995_T2",
"type": "Drug_or_compound",
"text": [
"AGE"
],
"offsets": [
[
... | [
{
"id": "PMID-16720995_E1",
"type": "Breakdown",
"trigger": {
"text": [
"damage"
],
"offsets": [
[
48,
54
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16720995_T3"
}
]
},
{
"id... | [
{
"id": "PMID-16720995_1",
"entity_ids": [
"PMID-16720995_T6",
"PMID-16720995_T7"
]
},
{
"id": "PMID-16720995_2",
"entity_ids": [
"PMID-16720995_T10",
"PMID-16720995_T11"
]
},
{
"id": "PMID-16720995_3",
"entity_ids": [
"PMID-16720995_T26",
... | [] |
26 | PMID-19622586 | [
{
"id": "PMID-19622586__text",
"type": "abstract",
"text": [
"EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation.\n\nPURPOSE: Antiangiogenic therapy is considered as an effective strategy for controlling the growth and metastasis of tumors. Among a myriad of biological act... | [
{
"id": "PMID-19622586_T1",
"type": "Drug_or_compound",
"text": [
"EPOX"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "PMID-19622586_T5",
"type": "Gene_or_gene_product",
"text": [
"Mcl-1"
],
"offsets": [
[
... | [
{
"id": "PMID-19622586_E4",
"type": "Catabolism",
"trigger": {
"text": [
"degradation"
],
"offsets": [
[
30,
41
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19622586_T5"
}
]
},
{
... | [
{
"id": "PMID-19622586_1",
"entity_ids": [
"PMID-19622586_T15",
"PMID-19622586_T16"
]
},
{
"id": "PMID-19622586_2",
"entity_ids": [
"PMID-19622586_T43",
"PMID-19622586_T44"
]
},
{
"id": "PMID-19622586_3",
"entity_ids": [
"PMID-19622586_T57",
... | [] |
27 | PMID-11835401 | [
{
"id": "PMID-11835401__text",
"type": "abstract",
"text": [
"Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors.\n\nInteractions among growth factors, cells, a... | [
{
"id": "PMID-11835401_T2",
"type": "Gene_or_gene_product",
"text": [
"PDGF"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "PMID-11835401_T4",
"type": "Cellular_component",
"text": [
"matrix"
],
"offsets": [
... | [
{
"id": "PMID-11835401_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"Inhibition"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-11835401_T9"
},
{
... | [
{
"id": "PMID-11835401_1",
"entity_ids": [
"PMID-11835401_T15",
"PMID-11835401_T16"
]
}
] | [] |
28 | PMID-15331370 | [
{
"id": "PMID-15331370__text",
"type": "abstract",
"text": [
"Enhanced IGF-1 expression improves smooth muscle cell engraftment after cell transplantation.\n\nThe functional benefit of cell transplantation after a myocardial infarction is diminished by early cell losses. IGF-1 enhances cell prolif... | [
{
"id": "PMID-15331370_T3",
"type": "Gene_or_gene_product",
"text": [
"IGF-1"
],
"offsets": [
[
9,
14
]
],
"normalized": []
},
{
"id": "PMID-15331370_T4",
"type": "Cell",
"text": [
"smooth muscle cell"
],
"offsets": [
... | [
{
"id": "PMID-15331370_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"Enhanced"
],
"offsets": [
[
0,
8
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-15331370_E2"
}
]
},
... | [
{
"id": "PMID-15331370_1",
"entity_ids": [
"PMID-15331370_T8",
"PMID-15331370_T9"
]
}
] | [] |
29 | PMID-16374459 | [
{
"id": "PMID-16374459__text",
"type": "abstract",
"text": [
"Regulation of skin microvasculature angiogenesis, cell migration, and permeability by a specific inhibitor of PKCalpha.\n\nActivation of protein kinase C (PKC) induces phenotypic changes in the morphology of microvascular endothelial ce... | [
{
"id": "PMID-16374459_T2",
"type": "Tissue",
"text": [
"skin microvasculature"
],
"offsets": [
[
14,
35
]
],
"normalized": []
},
{
"id": "PMID-16374459_T6",
"type": "Gene_or_gene_product",
"text": [
"PKCalpha"
],
"offsets":... | [
{
"id": "PMID-16374459_E8",
"type": "Regulation",
"trigger": {
"text": [
"changes"
],
"offsets": [
[
177,
184
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16374459_T13"
}
]
},
{
... | [
{
"id": "PMID-16374459_1",
"entity_ids": [
"PMID-16374459_T10",
"PMID-16374459_T11"
]
}
] | [] |
30 | PMID-14555793 | [
{
"id": "PMID-14555793__text",
"type": "abstract",
"text": [
"Therapeutic angiogenesis: a complex problem requiring a sophisticated approach.\n\nBlood and vascular disorders underlie a plethora of pathologic conditions and are the single most frequent cause of human disease. Ischemia, involving re... | [
{
"id": "PMID-14555793_T2",
"type": "Organism_substance",
"text": [
"Blood"
],
"offsets": [
[
81,
86
]
],
"normalized": []
},
{
"id": "PMID-14555793_T4",
"type": "Organism_substance",
"text": [
"blood"
],
"offsets": [
... | [
{
"id": "PMID-14555793_E1",
"type": "Breakdown",
"trigger": {
"text": [
"dysfunction"
],
"offsets": [
[
306,
317
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-14555793_T5"
}
]
},
{
... | [] | [
{
"id": "PMID-14555793_R1",
"type": "frag",
"arg1_id": "PMID-14555793_T7",
"arg2_id": "PMID-14555793_T8",
"normalized": []
},
{
"id": "PMID-14555793_R2",
"type": "frag",
"arg1_id": "PMID-14555793_T3",
"arg2_id": "PMID-14555793_T20",
"normalized": []
}
] |
31 | PMID-16907772 | [
{
"id": "PMID-16907772__text",
"type": "abstract",
"text": [
"Formation of new bone during vertical distraction osteogenesis of the human mandible is related to the presence of blood vessels.\n\nWe examined the effect of distraction rate on blood vessel growth in intramembraneous ossification afte... | [
{
"id": "PMID-16907772_T1",
"type": "Tissue",
"text": [
"bone"
],
"offsets": [
[
17,
21
]
],
"normalized": []
},
{
"id": "PMID-16907772_T2",
"type": "Organ",
"text": [
"mandible"
],
"offsets": [
[
76,
8... | [
{
"id": "PMID-16907772_E5",
"type": "Growth",
"trigger": {
"text": [
"growth"
],
"offsets": [
[
190,
196
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16907772_T6"
}
]
},
{
"id"... | [] | [] |
32 | PMID-19695243 | [
{
"id": "PMID-19695243__text",
"type": "abstract",
"text": [
"Metronomic 5-fluorouracil, oxaliplatin and irinotecan in colorectal cancer.\n\nMetronomic chemotherapy (the frequent, long term, low dose administration of chemotherapeutic drugs) is a promising therapy because it enhances the anti-endo... | [
{
"id": "PMID-19695243_T1",
"type": "Drug_or_compound",
"text": [
"5-fluorouracil"
],
"offsets": [
[
11,
25
]
],
"normalized": []
},
{
"id": "PMID-19695243_T2",
"type": "Drug_or_compound",
"text": [
"oxaliplatin"
],
"offsets... | [
{
"id": "PMID-19695243_E13",
"type": "Localization",
"trigger": {
"text": [
"secretion"
],
"offsets": [
[
744,
753
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19695243_T14"
}
]
},
... | [
{
"id": "PMID-19695243_1",
"entity_ids": [
"PMID-19695243_T14",
"PMID-19695243_T15"
]
},
{
"id": "PMID-19695243_2",
"entity_ids": [
"PMID-19695243_T7",
"PMID-19695243_T8"
]
},
{
"id": "PMID-19695243_3",
"entity_ids": [
"PMID-19695243_T9",
"... | [
{
"id": "PMID-19695243_R1",
"type": "frag",
"arg1_id": "PMID-19695243_T16",
"arg2_id": "PMID-19695243_T17",
"normalized": []
},
{
"id": "PMID-19695243_R2",
"type": "frag",
"arg1_id": "PMID-19695243_T39",
"arg2_id": "PMID-19695243_T40",
"normalized": []
}
] |
33 | PMID-15015551 | [
{
"id": "PMID-15015551__text",
"type": "abstract",
"text": [
"Morphogenesis of embryonic CNS vessels.\n\nThis chapter focuses on the morphology of blood vessel formation in and around the early central nervous system (CNS, i.e., brain and spinal cord) of avian embryos. We discuss cell lineages, pr... | [
{
"id": "PMID-15015551_T1",
"type": "Multi-tissue_structure",
"text": [
"embryonic CNS vessels"
],
"offsets": [
[
17,
38
]
],
"normalized": []
},
{
"id": "PMID-15015551_T5",
"type": "Multi-tissue_structure",
"text": [
"blood vessel"... | [
{
"id": "PMID-15015551_E4",
"type": "Development",
"trigger": {
"text": [
"formation"
],
"offsets": [
[
96,
105
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-15015551_T5"
}
]
},
{
... | [
{
"id": "PMID-15015551_1",
"entity_ids": [
"PMID-15015551_T6",
"PMID-15015551_T7"
]
}
] | [] |
34 | PMID-18565374 | [
{
"id": "PMID-18565374__text",
"type": "abstract",
"text": [
"Contemporary perspectives on vital pulp therapy: views from the endodontists and pediatric dentists.\n\nThe purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symp... | [
{
"id": "PMID-18565374_T1",
"type": "Tissue",
"text": [
"pulp"
],
"offsets": [
[
35,
39
]
],
"normalized": []
},
{
"id": "PMID-18565374_T2",
"type": "Tissue",
"text": [
"pulp"
],
"offsets": [
[
217,
221... | [
{
"id": "PMID-18565374_E1",
"type": "Planned_process",
"trigger": {
"text": [
"therapy"
],
"offsets": [
[
40,
47
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-18565374_T1"
}
]
},
{
... | [] | [] |
35 | PMID-18469146 | [
{
"id": "PMID-18469146__text",
"type": "abstract",
"text": [
"Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells.\n\nPhysiological angiogenesis is regulated by various factors, including signaling through vascular endothelial growth factor (VEGF) receptors. We previo... | [
{
"id": "PMID-18469146_T1",
"type": "Drug_or_compound",
"text": [
"ethanol"
],
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[
6,
13
]
],
"normalized": []
},
{
"id": "PMID-18469146_T4",
"type": "Gene_or_gene_product",
"text": [
"VEGF receptor"
],
"offsets":... | [
{
"id": "PMID-18469146_E2",
"type": "Negative_regulation",
"trigger": {
"text": [
"disrupts"
],
"offsets": [
[
23,
31
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-18469146_E1"
},
{
... | [] | [] |
36 | PMID-8874381 | [
{
"id": "PMID-8874381__text",
"type": "abstract",
"text": [
"Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo.\n\nVascular endothelial growth factor (VEGF) is a naturally secreted endothelial cell-specific mitoge... | [
{
"id": "PMID-8874381_T1",
"type": "Gene_or_gene_product",
"text": [
"vascular endothelial growth factor"
],
"offsets": [
[
58,
92
]
],
"normalized": []
},
{
"id": "PMID-8874381_T2",
"type": "Gene_or_gene_product",
"text": [
"Vascul... | [
{
"id": "PMID-8874381_E9",
"type": "Development",
"trigger": {
"text": [
"development"
],
"offsets": [
[
386,
397
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-8874381_T10"
}
]
},
{... | [
{
"id": "PMID-8874381_1",
"entity_ids": [
"PMID-8874381_T2",
"PMID-8874381_T3"
]
}
] | [
{
"id": "PMID-8874381_R1",
"type": "frag",
"arg1_id": "PMID-8874381_T8",
"arg2_id": "PMID-8874381_T23",
"normalized": []
}
] |
37 | PMID-12727857 | [
{
"id": "PMID-12727857__text",
"type": "abstract",
"text": [
"Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression.\n\nThe expression of endothelial cell (EC) adhesion molecules involved in leukocyte-vessel wall interactions i... | [
{
"id": "PMID-12727857_T1",
"type": "Pathological_formation",
"text": [
"Tumor"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "PMID-12727857_T5",
"type": "Cell",
"text": [
"leukocyte"
],
"offsets": [
[
... | [
{
"id": "PMID-12727857_E3",
"type": "Regulation",
"trigger": {
"text": [
"modulates"
],
"offsets": [
[
19,
28
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12727857_E4"
},
{
"... | [] | [] |
38 | PMID-10978248 | [
{
"id": "PMID-10978248__text",
"type": "abstract",
"text": [
"Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells.\n\nVasodilator-stimulated phosphoprotein (VASP) is highly expressed in vascular endothelial cells, where it has been i... | [
{
"id": "PMID-10978248_T1",
"type": "Gene_or_gene_product",
"text": [
"Vasodilator-stimulated phosphoprotein"
],
"offsets": [
[
0,
37
]
],
"normalized": []
},
{
"id": "PMID-10978248_T3",
"type": "Cellular_component",
"text": [
"stre... | [
{
"id": "PMID-10978248_E2",
"type": "Development",
"trigger": {
"text": [
"formation"
],
"offsets": [
[
86,
95
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10978248_T4"
}
]
},
{
... | [
{
"id": "PMID-10978248_1",
"entity_ids": [
"PMID-10978248_T6",
"PMID-10978248_T7"
]
}
] | [
{
"id": "PMID-10978248_R1",
"type": "frag",
"arg1_id": "PMID-10978248_T45",
"arg2_id": "PMID-10978248_T41",
"normalized": []
}
] |
39 | PMID-15623651 | [
{
"id": "PMID-15623651__text",
"type": "abstract",
"text": [
"2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma.\n\nPURPOSE: Head and neck squamous cell carcinomas have been reported... | [
{
"id": "PMID-15623651_T1",
"type": "Drug_or_compound",
"text": [
"2-methoxyestradiol"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "PMID-15623651_T4",
"type": "Gene_or_gene_product",
"text": [
"hypoxia-inducible factor ... | [
{
"id": "PMID-15623651_E2",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibits"
],
"offsets": [
[
19,
27
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-15623651_T1"
},
{
... | [
{
"id": "PMID-15623651_1",
"entity_ids": [
"PMID-15623651_T20",
"PMID-15623651_T21"
]
}
] | [
{
"id": "PMID-15623651_R1",
"type": "frag",
"arg1_id": "PMID-15623651_T40",
"arg2_id": "PMID-15623651_T41",
"normalized": []
}
] |
40 | PMID-19292679 | [
{
"id": "PMID-19292679__text",
"type": "abstract",
"text": [
"The effect of perfluorocarbon-based artificial oxygen carriers on tissue-engineered trachea.\n\nThe biological effect of the perfluorocarbon-based artificial oxygen carrier (Oxygent) was investigated in tissue-engineered trachea (TET) c... | [
{
"id": "PMID-19292679_T2",
"type": "Drug_or_compound",
"text": [
"perfluorocarbon"
],
"offsets": [
[
14,
29
]
],
"normalized": []
},
{
"id": "PMID-19292679_T3",
"type": "Drug_or_compound",
"text": [
"oxygen"
],
"offsets": [... | [
{
"id": "PMID-19292679_E38",
"type": "Negative_regulation",
"trigger": {
"text": [
"slow"
],
"offsets": [
[
1795,
1799
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-19292679_T33"
},
{... | [
{
"id": "PMID-19292679_1",
"entity_ids": [
"PMID-19292679_T9",
"PMID-19292679_T10"
]
}
] | [] |
41 | PMID-11425277 | [
{
"id": "PMID-11425277__text",
"type": "abstract",
"text": [
"Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs.\n\nIn animal or cell culture studies, the growth and spread of cancer can be slowed by many nutr... | [
{
"id": "PMID-11425277_T3",
"type": "Pathological_formation",
"text": [
"cancer"
],
"offsets": [
[
34,
40
]
],
"normalized": []
},
{
"id": "PMID-11425277_T6",
"type": "Pathological_formation",
"text": [
"cancer"
],
"offsets"... | [
{
"id": "PMID-11425277_E1",
"type": "Regulation",
"trigger": {
"text": [
"controlling"
],
"offsets": [
[
22,
33
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11425277_E2"
}
]
},
{
... | [] | [] |
42 | PMID-707591 | [
{
"id": "PMID-707591__text",
"type": "abstract",
"text": [
"Subretinal neovascularization following rubella retinopathy.\n\nA 17-year-old girl and an 11-year-old girl with rubella retinopathy had decreased vision in one eye secondary to subretinal neovascularization and hemorrhage. In both cases a... | [
{
"id": "PMID-707591_T2",
"type": "Organ",
"text": [
"eye"
],
"offsets": [
[
158,
161
]
],
"normalized": []
},
{
"id": "PMID-707591_T1000",
"type": "Organism",
"text": [
"girl"
],
"offsets": [
[
76,
80
... | [
{
"id": "PMID-707591_E1",
"type": "Blood_vessel_development",
"trigger": {
"text": [
"neovascularization"
],
"offsets": [
[
11,
29
]
]
},
"arguments": []
},
{
"id": "PMID-707591_E2",
"type": "Blood_vessel_development... | [] | [] |
43 | PMID-10816661 | [
{
"id": "PMID-10816661__text",
"type": "abstract",
"text": [
"Alpha-melanocyte-stimulating hormone modulates activation of NF-kappa B and AP-1 and secretion of interleukin-8 in human dermal fibroblasts.\n\nAlpha-melanocyte-stimulating hormone (alpha-MSH) has evolved as a mediator of diverse biolog... | [
{
"id": "PMID-10816661_T1",
"type": "Gene_or_gene_product",
"text": [
"Alpha-melanocyte-stimulating hormone"
],
"offsets": [
[
0,
36
]
],
"normalized": []
},
{
"id": "PMID-10816661_T4",
"type": "Gene_or_gene_product",
"text": [
"NF-... | [
{
"id": "PMID-10816661_E3",
"type": "Positive_regulation",
"trigger": {
"text": [
"activation"
],
"offsets": [
[
47,
57
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10816661_T4"
}
]
... | [
{
"id": "PMID-10816661_1",
"entity_ids": [
"PMID-10816661_T10",
"PMID-10816661_T9"
]
},
{
"id": "PMID-10816661_2",
"entity_ids": [
"PMID-10816661_T36",
"PMID-10816661_T35"
]
},
{
"id": "PMID-10816661_3",
"entity_ids": [
"PMID-10816661_T25",
... | [] |
44 | PMID-11381168 | [
{
"id": "PMID-11381168__text",
"type": "abstract",
"text": [
"Effects of morphological patterning on endothelial cell migration.\n\nThe migration of vascular endothelial cells (ECs) plays an important role in vascular remodeling. Here we studied the effects of cell morphology on the migration of b... | [
{
"id": "PMID-11381168_T3",
"type": "Cell",
"text": [
"endothelial cell"
],
"offsets": [
[
39,
55
]
],
"normalized": []
},
{
"id": "PMID-11381168_T6",
"type": "Cell",
"text": [
"vascular endothelial cells"
],
"offsets": [
... | [
{
"id": "PMID-11381168_E2",
"type": "Localization",
"trigger": {
"text": [
"migration"
],
"offsets": [
[
56,
65
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11381168_T3"
}
]
},
{
... | [
{
"id": "PMID-11381168_1",
"entity_ids": [
"PMID-11381168_T6",
"PMID-11381168_T8"
]
}
] | [] |
45 | PMID-12920663 | [
{
"id": "PMID-12920663__text",
"type": "abstract",
"text": [
"Proliferative diabetic retinopathy is associated with a low level of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor. a pilot study.\n\nRetinopathy is the most common microvascular diab... | [
{
"id": "PMID-12920663_T2",
"type": "Gene_or_gene_product",
"text": [
"pigment epithelium-derived factor"
],
"offsets": [
[
110,
143
]
],
"normalized": []
},
{
"id": "PMID-12920663_T3",
"type": "Gene_or_gene_product",
"text": [
"PED... | [
{
"id": "PMID-12920663_E20",
"type": "Localization",
"trigger": {
"text": [
"migration"
],
"offsets": [
[
808,
817
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12920663_T21"
}
]
},
... | [
{
"id": "PMID-12920663_1",
"entity_ids": [
"PMID-12920663_T14",
"PMID-12920663_T15"
]
},
{
"id": "PMID-12920663_2",
"entity_ids": [
"PMID-12920663_T11",
"PMID-12920663_T12"
]
},
{
"id": "PMID-12920663_3",
"entity_ids": [
"PMID-12920663_T2",
... | [] |
46 | PMID-18319331 | [
{
"id": "PMID-18319331__text",
"type": "abstract",
"text": [
"Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma.\n\nWe hypothesized that signaling through multiple mitogen-activated protein kinase (MAPK) kinase (MKK) pathways is essential for the... | [
{
"id": "PMID-18319331_T2",
"type": "Gene_or_gene_product",
"text": [
"Mitogen-activated protein kinase kinase"
],
"offsets": [
[
0,
39
]
],
"normalized": []
},
{
"id": "PMID-18319331_T6",
"type": "Pathological_formation",
"text": [
... | [
{
"id": "PMID-18319331_E24",
"type": "Negative_regulation",
"trigger": {
"text": [
"inactivates"
],
"offsets": [
[
480,
491
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-18319331_T22"
},
... | [
{
"id": "PMID-18319331_1",
"entity_ids": [
"PMID-18319331_T8",
"PMID-18319331_T11"
]
},
{
"id": "PMID-18319331_2",
"entity_ids": [
"PMID-18319331_T22",
"PMID-18319331_T23"
]
}
] | [
{
"id": "PMID-18319331_R1",
"type": "frag",
"arg1_id": "PMID-18319331_T9",
"arg2_id": "PMID-18319331_T3",
"normalized": []
},
{
"id": "PMID-18319331_R2",
"type": "frag",
"arg1_id": "PMID-18319331_T10",
"arg2_id": "PMID-18319331_T3",
"normalized": []
}
] |
47 | PMID-19080335 | [
{
"id": "PMID-19080335__text",
"type": "abstract",
"text": [
"Effect of transplanted mesenchymal stem cells from rats of different ages on the improvement of heart function after acute myocardial infarction.\n\nBACKGROUND: Mesenchymal stem cells (MSCs) transplantation is of therapeutic potential a... | [
{
"id": "PMID-19080335_T2",
"type": "Cell",
"text": [
"mesenchymal stem cells"
],
"offsets": [
[
23,
45
]
],
"normalized": []
},
{
"id": "PMID-19080335_T3",
"type": "Organ",
"text": [
"heart"
],
"offsets": [
[
... | [
{
"id": "PMID-19080335_E1",
"type": "Planned_process",
"trigger": {
"text": [
"transplanted"
],
"offsets": [
[
10,
22
]
]
},
"arguments": [
{
"role": "Instrument",
"ref_id": "PMID-19080335_T2"
}
]... | [
{
"id": "PMID-19080335_1",
"entity_ids": [
"PMID-19080335_T5",
"PMID-19080335_T6"
]
},
{
"id": "PMID-19080335_2",
"entity_ids": [
"PMID-19080335_T17",
"PMID-19080335_T18"
]
}
] | [] |
48 | PMID-19509166 | [
{
"id": "PMID-19509166__text",
"type": "abstract",
"text": [
"Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma.\n\nPURPOSE: Tumor fibroblasts (TF) have been suggested to play an essential role... | [
{
"id": "PMID-19509166_T1",
"type": "Cell",
"text": [
"Fibroblast growth factor receptor 2-positive fibroblasts"
],
"offsets": [
[
0,
56
]
],
"normalized": []
},
{
"id": "PMID-19509166_T2",
"type": "Gene_or_gene_product",
"text": [
... | [
{
"id": "PMID-19509166_E3",
"type": "Development",
"trigger": {
"text": [
"progression"
],
"offsets": [
[
119,
130
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19509166_T6"
}
]
},
... | [
{
"id": "PMID-19509166_1",
"entity_ids": [
"PMID-19509166_T20",
"PMID-19509166_T21"
]
},
{
"id": "PMID-19509166_2",
"entity_ids": [
"PMID-19509166_T7",
"PMID-19509166_T9"
]
},
{
"id": "PMID-19509166_3",
"entity_ids": [
"PMID-19509166_T15",
... | [] |
49 | PMID-12154044 | [
{
"id": "PMID-12154044__text",
"type": "abstract",
"text": [
"Inhibition of angiogenesis by the cancer chemopreventive agent conjugated linoleic acid.\n\nDietary conjugated linoleic acid (CLA) has been shown previously to inhibit rat mammary carcinogenesis. In addition to direct effects on mammary... | [
{
"id": "PMID-12154044_T3",
"type": "Drug_or_compound",
"text": [
"conjugated linoleic acid"
],
"offsets": [
[
63,
87
]
],
"normalized": []
},
{
"id": "PMID-12154044_T4",
"type": "Drug_or_compound",
"text": [
"conjugated linoleic ac... | [
{
"id": "PMID-12154044_E9",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibiting"
],
"offsets": [
[
354,
364
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12154044_E10"
},
... | [
{
"id": "PMID-12154044_1",
"entity_ids": [
"PMID-12154044_T4",
"PMID-12154044_T5"
]
},
{
"id": "PMID-12154044_2",
"entity_ids": [
"PMID-12154044_T43",
"PMID-12154044_T44"
]
}
] | [
{
"id": "PMID-12154044_R1",
"type": "frag",
"arg1_id": "PMID-12154044_T50",
"arg2_id": "PMID-12154044_T51",
"normalized": []
},
{
"id": "PMID-12154044_R2",
"type": "frag",
"arg1_id": "PMID-12154044_T49",
"arg2_id": "PMID-12154044_T51",
"normalized": []
},
{
"id": ... |
50 | PMID-19082449 | [
{
"id": "PMID-19082449__text",
"type": "abstract",
"text": [
"Clinical significance of chicken ovalbumin upstream promoter-transcription factor II expression in human colorectal cancer.\n\nChicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) plays an essential role in angiogenes... | [
{
"id": "PMID-19082449_T2",
"type": "Gene_or_gene_product",
"text": [
"chicken ovalbumin upstream promoter-transcription factor II"
],
"offsets": [
[
25,
84
]
],
"normalized": []
},
{
"id": "PMID-19082449_T3",
"type": "Pathological_formation"... | [
{
"id": "PMID-19082449_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
85,
95
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19082449_T2"
}
]
},
... | [
{
"id": "PMID-19082449_1",
"entity_ids": [
"PMID-19082449_T4",
"PMID-19082449_T5"
]
},
{
"id": "PMID-19082449_2",
"entity_ids": [
"PMID-19082449_T36",
"PMID-19082449_T37"
]
}
] | [] |
51 | PMID-10543260 | [
{
"id": "PMID-10543260__text",
"type": "abstract",
"text": [
"Increased serum levels of vascular endothelial growth factor in patients with renal cell carcinoma.\n\nNeovascularization, an essential event for the growth of solid tumors, is regulated by a number of angiogenic factors. One such facto... | [
{
"id": "PMID-10543260_T1",
"type": "Organism_substance",
"text": [
"serum"
],
"offsets": [
[
10,
15
]
],
"normalized": []
},
{
"id": "PMID-10543260_T2",
"type": "Gene_or_gene_product",
"text": [
"vascular endothelial growth factor"... | [
{
"id": "PMID-10543260_E7",
"type": "Growth",
"trigger": {
"text": [
"growth"
],
"offsets": [
[
148,
154
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10543260_T8"
}
]
},
{
"id"... | [
{
"id": "PMID-10543260_1",
"entity_ids": [
"PMID-10543260_T10",
"PMID-10543260_T11"
]
},
{
"id": "PMID-10543260_2",
"entity_ids": [
"PMID-10543260_T17",
"PMID-10543260_T4"
]
}
] | [] |
52 | PMID-15034798 | [
{
"id": "PMID-15034798__text",
"type": "abstract",
"text": [
"Role of thrombin in angiogenesis and tumor progression.\n\nClinical, laboratory, histopathological, and pharmacological evidence support the notion that the coagulation system, which is activated in most cancer patients, plays an import... | [
{
"id": "PMID-15034798_T1",
"type": "Gene_or_gene_product",
"text": [
"thrombin"
],
"offsets": [
[
8,
16
]
],
"normalized": []
},
{
"id": "PMID-15034798_T4",
"type": "Gene_or_gene_product",
"text": [
"thrombin"
],
"offsets":... | [
{
"id": "PMID-15034798_E7",
"type": "Growth",
"trigger": {
"text": [
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... | [] |
53 | PMID-19075960 | [
{
"id": "PMID-19075960__text",
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[
... | [
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},
{
"id": "P... |
54 | PMID-16407289 | [
{
"id": "PMID-16407289__text",
"type": "abstract",
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{
"id": "PMID-16407289_T1",
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37,
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},
{
"id": "PMID-16407289_T2",
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... | [
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"P... | [] |
55 | PMID-12384438 | [
{
"id": "PMID-12384438__text",
"type": "abstract",
"text": [
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{
"id": "PMID-12384438_T2",
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],
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},
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"id": "PMID-12384438_T6",
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},
... | [
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"normalized": []
}
] |
56 | PMID-18043872 | [
{
"id": "PMID-18043872__text",
"type": "abstract",
"text": [
"Tumor microenvironment, a dangerous society leading to cancer metastasis. From mechanisms to therapy and prevention.\n\nCancer is no longer considered by scientists just a jumble of mutated cells. To grow, invade and metastasize, a trea... | [
{
"id": "PMID-18043872_T1",
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0,
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"text": [
"host cells"
],
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[
... | [
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"id": "PMID-18043872_E1",
"type": "Growth",
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"grow"
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]
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},
{
"id": ... | [] | [
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"arg2_id": "PMID-18043872_T4",
"normalized": []
}
] |
57 | PMID-19654314 | [
{
"id": "PMID-19654314__text",
"type": "abstract",
"text": [
"Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity.\n\nRecruiting a new blood supply is a rate-limiting step in tumor progression. In a three-dimensional model o... | [
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"id": "PMID-19654314_T3",
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0,
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... | [
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... | [
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"PMID-19654314_T19"
]
}
] | [] |
58 | PMID-19372461 | [
{
"id": "PMID-19372461__text",
"type": "abstract",
"text": [
"Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells.\n\nOBJECTIVE: Vascular endothelial growth factor receptor 2 (VEGFR2) is a receptor tyrosine kinase that regulates vascular physiology. However, mechanism(s)... | [
{
"id": "PMID-19372461_T2",
"type": "Gene_or_gene_product",
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0,
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"id": "PMID-19372461_T5",
"type": "Gene_or_gene_product",
"text": [
"VEGFR2"
],
"offsets":... | [
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"id": "PMID-19372461_E1",
"type": "Regulation",
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11,
21
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19372461_E4"
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{
... | [
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"PMID-19372461_T45",
"PMID-19372461_T46"
]
}
] | [] |
59 | PMID-19446450 | [
{
"id": "PMID-19446450__text",
"type": "abstract",
"text": [
"AngiomiRs--key regulators of angiogenesis.\n\nThe formation of new blood vessels through the process of angiogenesis is critical in vascular development and homeostasis. Aberrant angiogenesis leads to a variety of diseases, such as isch... | [
{
"id": "PMID-19446450_T1",
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0,
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},
{
"id": "PMID-19446450_T4",
"type": "Multi-tissue_structure",
"text": [
"blood vessels"
],
"of... | [
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"id": "PMID-19446450_E8",
"type": "Development",
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"role": "Theme",
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},
... | [
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}
] | [
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"arg2_id": "PMID-19446450_T35",
"normalized": []
}
] |
60 | PMID-15586242 | [
{
"id": "PMID-15586242__text",
"type": "abstract",
"text": [
"Hypoxia-responsive element-mediated soluble Tie2 vector exhibits an anti-angiogenic activity in vitro under hypoxic condition.\n\nHypoxia-inducible factor-1 (HIF-1) is one of the key mammalian transcription factors and shows increased l... | [
{
"id": "PMID-15586242_T3",
"type": "Gene_or_gene_product",
"text": [
"Tie2"
],
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44,
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},
{
"id": "PMID-15586242_T5",
"type": "Gene_or_gene_product",
"text": [
"Hypoxia-inducible factor-1"
],... | [
{
"id": "PMID-15586242_E7",
"type": "Binding",
"trigger": {
"text": [
"binds"
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375,
380
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},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-15586242_T11"
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{
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},
{
"id": "PMID-15586242_3",
"entity_ids": [
"PMID-15586242_T16",
"... | [] |
61 | PMID-15225208 | [
{
"id": "PMID-15225208__text",
"type": "abstract",
"text": [
"Matrix metalloproteinase activity and immunohistochemical profile of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 during human dermal wound healing.\n\nProteolytic activity is required for the turnover o... | [
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"id": "PMID-15225208_T1",
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0,
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{
"id": "PMID-15225208_T2",
"type": "Gene_or_gene_product",
"text": [
"-9"
],
... | [
{
"id": "PMID-15225208_E15",
"type": "Positive_regulation",
"trigger": {
"text": [
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],
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"arguments": [
{
"role": "Theme",
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... | [] | [
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},
{
"id": ... |
62 | PMID-19489226 | [
{
"id": "PMID-19489226__text",
"type": "abstract",
"text": [
"[Activation of sterol regulatory element binding protein and its involvement in endothelial cell migration]\n\nOBJECTIVE: To study the activation of sterol regulatory element binding protein (SREBP) and its critical role in endothelial ... | [
{
"id": "PMID-19489226_T2",
"type": "Gene_or_gene_product",
"text": [
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],
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},
{
"id": "PMID-19489226_T6",
"type": "Cell",
"text": [
"endothelial c... | [
{
"id": "PMID-19489226_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"Activation"
],
"offsets": [
[
1,
11
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19489226_T2"
}
]
}... | [
{
"id": "PMID-19489226_1",
"entity_ids": [
"PMID-19489226_T8",
"PMID-19489226_T9"
]
}
] | [] |
63 | PMID-11912515 | [
{
"id": "PMID-11912515__text",
"type": "abstract",
"text": [
"Upregulation of vascular endothelial growth factor receptors is associated with advanced neuroblastoma.\n\nBACKGROUND: Angiogenesis is essential for tumor growth and relies on the production of angiogenic factors. Vascular endothelial g... | [
{
"id": "PMID-11912515_T2",
"type": "Gene_or_gene_product",
"text": [
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],
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16,
60
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],
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},
{
"id": "PMID-11912515_T5",
"type": "Pathological_formation",
"text": [... | [
{
"id": "PMID-11912515_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"Upregulation"
],
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0,
12
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]
},
"arguments": [
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"role": "Theme",
"ref_id": "PMID-11912515_T2"
}
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... | [
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"id": "PMID-11912515_1",
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"PMID-11912515_T8"
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}
] | [
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"arg1_id": "PMID-11912515_T23",
"arg2_id": "PMID-11912515_T24",
"normalized": []
},
{
"id": ... |
64 | PMID-18313522 | [
{
"id": "PMID-18313522__text",
"type": "abstract",
"text": [
"Radiation retinopathy is treatable with anti-vascular endothelial growth factor bevacizumab (Avastin).\n\nPURPOSE: To report on bevacizumab treatment for radiation retinopathy affecting the macula. PATIENTS AND METHODS: Twenty-one patie... | [
{
"id": "PMID-18313522_T2",
"type": "Gene_or_gene_product",
"text": [
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],
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45,
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},
{
"id": "PMID-18313522_T3",
"type": "Drug_or_compound",
"text": [
"bevacizu... | [
{
"id": "PMID-18313522_E1",
"type": "Planned_process",
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"text": [
"treatment"
],
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138,
147
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]
},
"arguments": [
{
"role": "Instrument",
"ref_id": "PMID-18313522_T5"
}
]
... | [
{
"id": "PMID-18313522_1",
"entity_ids": [
"PMID-18313522_T3",
"PMID-18313522_T4"
]
}
] | [] |
65 | PMID-12869564 | [
{
"id": "PMID-12869564__text",
"type": "abstract",
"text": [
"The role of organ vascularization and lipoplex-serum initial contact in intravenous murine lipofection.\n\nFollowing intravenous administration of cationic lipid-DNA complexes (lipoplexes) into mice, transfection (lipofection) occurs pr... | [
{
"id": "PMID-12869564_T2",
"type": "Drug_or_compound",
"text": [
"lipoplex"
],
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38,
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"id": "PMID-12869564_T3",
"type": "Organism_substance",
"text": [
"serum"
],
"offsets": [
... | [
{
"id": "PMID-12869564_E6",
"type": "Localization",
"trigger": {
"text": [
"entrapment"
],
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288,
298
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12869564_T7"
},
{
... | [] | [] |
66 | PMID-14500555 | [
{
"id": "PMID-14500555__text",
"type": "abstract",
"text": [
"Transcriptional and post-translation regulation of the Tie1 receptor by fluid shear stress changes in vascular endothelial cells.\n\nThe interaction between the vascular endothelium and hemodynamic forces (and more specifically, fluid s... | [
{
"id": "PMID-14500555_T2",
"type": "Gene_or_gene_product",
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],
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55,
68
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],
"normalized": []
},
{
"id": "PMID-14500555_T3",
"type": "Cell",
"text": [
"vascular endothelial cells"
],
"o... | [
{
"id": "PMID-14500555_E1",
"type": "Regulation",
"trigger": {
"text": [
"regulation"
],
"offsets": [
[
37,
47
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-14500555_E3"
}
]
},
{
... | [] | [] |
67 | PMID-18600526 | [
{
"id": "PMID-18600526__text",
"type": "abstract",
"text": [
"The role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in tumor behavior.\n\nPlatelet-derived endothelial cell growth-factor (PD-ECGF) is similar to the pyrimidine enzyme thymidine phosphorylase (TP). A high... | [
{
"id": "PMID-18600526_T1",
"type": "Gene_or_gene_product",
"text": [
"platelet-derived endothelial cell growth factor"
],
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[
12,
59
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],
"normalized": []
},
{
"id": "PMID-18600526_T3",
"type": "Gene_or_gene_product",
"text": ... | [
{
"id": "PMID-18600526_E10",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
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238,
248
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-18600526_T11"
}
]
... | [
{
"id": "PMID-18600526_1",
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},
{
"id": "PMID-18600526_2",
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"PMID-18600526_T29"
]
},
{
"id": "PMID-18600526_3",
"entity_ids": [
"PMID-18600526_T35",
... | [] |
68 | PMID-16470244 | [
{
"id": "PMID-16470244__text",
"type": "abstract",
"text": [
"Pericytes limit tumor cell metastasis.\n\nPreviously we observed that neural cell adhesion molecule (NCAM) deficiency in beta tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficien... | [
{
"id": "PMID-16470244_T1",
"type": "Cell",
"text": [
"Pericytes"
],
"offsets": [
[
0,
9
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],
"normalized": []
},
{
"id": "PMID-16470244_T3",
"type": "Cell",
"text": [
"tumor cell"
],
"offsets": [
[
16,
... | [
{
"id": "PMID-16470244_E2",
"type": "Localization",
"trigger": {
"text": [
"metastasis"
],
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27,
37
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16470244_T3"
}
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},
{
... | [
{
"id": "PMID-16470244_1",
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},
{
"id": "PMID-16470244_2",
"entity_ids": [
"PMID-16470244_T11",
"PMID-16470244_T25"
]
}
] | [] |
69 | PMID-17305525 | [
{
"id": "PMID-17305525__text",
"type": "abstract",
"text": [
"New vectors and strategies for cardiovascular gene therapy.\n\nCardiovascular diseases are the major cause of morbidity and mortality in both men and women in industrially developed countries. These disorders may result from impaired an... | [
{
"id": "PMID-17305525_T8",
"type": "Multi-tissue_structure",
"text": [
"vein grafts"
],
"offsets": [
[
469,
480
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],
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},
{
"id": "PMID-17305525_T9",
"type": "Drug_or_compound",
"text": [
"AAV serotypes"
],
"... | [
{
"id": "PMID-17305525_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"impaired"
],
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[
223,
231
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-17305525_E2"
}
]
... | [] | [] |
70 | PMID-15876269 | [
{
"id": "PMID-15876269__text",
"type": "abstract",
"text": [
"Rofecoxib as adjunctive therapy for haemophilic arthropathy.\n\nJoint haemorrhage and subsequent haemophilic arthropathy are significant complications in haemophilia. The pathophysiology involves inflammation and angiogenesis. Cyclooxyg... | [
{
"id": "PMID-15876269_T1",
"type": "Drug_or_compound",
"text": [
"Rofecoxib"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "PMID-15876269_T2",
"type": "Multi-tissue_structure",
"text": [
"Joint"
],
"offsets": [
... | [
{
"id": "PMID-15876269_E1",
"type": "Regulation",
"trigger": {
"text": [
"affect"
],
"offsets": [
[
380,
386
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-15876269_T9"
}
]
},
{
... | [
{
"id": "PMID-15876269_1",
"entity_ids": [
"PMID-15876269_T6",
"PMID-15876269_T5"
]
}
] | [] |
71 | PMID-17016553 | [
{
"id": "PMID-17016553__text",
"type": "abstract",
"text": [
"Imaging tumor angiogenesis.\n\nSince the discovery of vascular-specific growth factors with angiogenic activity, there has been a significant effort to develop cancer drugs that restrict tumorigenesis by targeting the blood supply. In t... | [
{
"id": "PMID-17016553_T1",
"type": "Pathological_formation",
"text": [
"tumor"
],
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[
8,
13
]
],
"normalized": []
},
{
"id": "PMID-17016553_T3",
"type": "Gene_or_gene_product",
"text": [
"vascular-specific growth factors... | [
{
"id": "PMID-17016553_E2",
"type": "Growth",
"trigger": {
"text": [
"regrowth"
],
"offsets": [
[
459,
467
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-17016553_T9"
}
]
},
{
"i... | [] | [] |
72 | PMID-8686754 | [
{
"id": "PMID-8686754__text",
"type": "abstract",
"text": [
"Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin.\n\nWe have identified several mech... | [
{
"id": "PMID-8686754_T3",
"type": "Cell",
"text": [
"endothelial cell"
],
"offsets": [
[
15,
31
]
],
"normalized": []
},
{
"id": "PMID-8686754_T4",
"type": "Gene_or_gene_product",
"text": [
"vascular permeability factor"
],
... | [
{
"id": "PMID-8686754_E2",
"type": "Localization",
"trigger": {
"text": [
"migration"
],
"offsets": [
[
32,
41
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-8686754_T3"
}
]
},
{
... | [
{
"id": "PMID-8686754_1",
"entity_ids": [
"PMID-8686754_T14",
"PMID-8686754_T15"
]
},
{
"id": "PMID-8686754_2",
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"PMID-8686754_T4",
"PMID-8686754_T31"
]
},
{
"id": "PMID-8686754_3",
"entity_ids": [
"PMID-8686754_T9",
"PMID-86... | [
{
"id": "PMID-8686754_R1",
"type": "frag",
"arg1_id": "PMID-8686754_T21",
"arg2_id": "PMID-8686754_T22",
"normalized": []
}
] |
73 | PMID-17157465 | [
{
"id": "PMID-17157465__text",
"type": "abstract",
"text": [
"Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer.\n\nThe last 7 years have seen over seven times as many publications indexed by Medline dealing with pomegranate and Punica granatum... | [
{
"id": "PMID-17157465_T1",
"type": "Organism_substance",
"text": [
"juice"
],
"offsets": [
[
690,
695
]
],
"normalized": []
},
{
"id": "PMID-17157465_T2",
"type": "Tissue",
"text": [
"peel"
],
"offsets": [
[
7... | [
{
"id": "PMID-17157465_E1",
"type": "Cell_proliferation",
"trigger": {
"text": [
"proliferation"
],
"offsets": [
[
1140,
1153
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-17157465_T12"
}
... | [] | [] |
74 | PMID-12405260 | [
{
"id": "PMID-12405260__text",
"type": "abstract",
"text": [
"Brn-3a, a neuronal transcription factor of the POU gene family: indications for its involvement in cancer and angiogenesis.\n\nBrn-3a, a member of the POU gene family (so-called because of the similarity with the group of transcription ... | [
{
"id": "PMID-12405260_T1",
"type": "Gene_or_gene_product",
"text": [
"Brn-3a"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "PMID-12405260_T5",
"type": "Gene_or_gene_product",
"text": [
"Brn-3a"
],
"offsets": [
... | [
{
"id": "PMID-12405260_E16",
"type": "Gene_expression",
"trigger": {
"text": [
"superexpression"
],
"offsets": [
[
642,
657
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12405260_T18"
}
... | [] | [] |
75 | PMID-19700757 | [
{
"id": "PMID-19700757__text",
"type": "abstract",
"text": [
"A key role for the integrin alpha2beta1 in experimental and developmental angiogenesis.\n\nThe alpha2beta1 integrin receptor plays a key role in angiogenesis. Here we investigated the effects of small molecule inhibitors (SMIs) designed... | [
{
"id": "PMID-19700757_T1",
"type": "Gene_or_gene_product",
"text": [
"integrin alpha2beta1"
],
"offsets": [
[
19,
39
]
],
"normalized": []
},
{
"id": "PMID-19700757_T3",
"type": "Gene_or_gene_product",
"text": [
"alpha2beta1 integr... | [
{
"id": "PMID-19700757_E20",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibited"
],
"offsets": [
[
671,
680
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19700757_E21"
},
... | [] | [
{
"id": "PMID-19700757_R1",
"type": "frag",
"arg1_id": "PMID-19700757_T4",
"arg2_id": "PMID-19700757_T6",
"normalized": []
}
] |
76 | PMID-1388088 | [
{
"id": "PMID-1388088__text",
"type": "abstract",
"text": [
"Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat.\n\nInterleukin-1 (IL-1) synthesis in the brain is stimulated by mechanical injury and IL-1 mimics some effects of injury, such as gliosis an... | [
{
"id": "PMID-1388088_T1",
"type": "Gene_or_gene_product",
"text": [
"Interleukin-1 receptor antagonist"
],
"offsets": [
[
0,
33
]
],
"normalized": []
},
{
"id": "PMID-1388088_T5",
"type": "Cell",
"text": [
"neuronal"
],
"of... | [
{
"id": "PMID-1388088_E3",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibits"
],
"offsets": [
[
34,
42
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-1388088_E4"
},
{
... | [
{
"id": "PMID-1388088_1",
"entity_ids": [
"PMID-1388088_T18",
"PMID-1388088_T20"
]
},
{
"id": "PMID-1388088_2",
"entity_ids": [
"PMID-1388088_T7",
"PMID-1388088_T8"
]
}
] | [] |
77 | PMID-17210799 | [
{
"id": "PMID-17210799__text",
"type": "abstract",
"text": [
"Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation.\n\n20-Hydroxyeicosatetraenoic acid (20-HETE) is formed by the omega-hydrox... | [
{
"id": "PMID-17210799_T2",
"type": "Gene_or_gene_product",
"text": [
"vascular endothelial growth factor"
],
"offsets": [
[
14,
48
]
],
"normalized": []
},
{
"id": "PMID-17210799_T4",
"type": "Drug_or_compound",
"text": [
"20-hydro... | [
{
"id": "PMID-17210799_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"Activation"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-17210799_T2"
}
]
}... | [
{
"id": "PMID-17210799_1",
"entity_ids": [
"PMID-17210799_T21",
"PMID-17210799_T22"
]
},
{
"id": "PMID-17210799_2",
"entity_ids": [
"PMID-17210799_T19",
"PMID-17210799_T20"
]
},
{
"id": "PMID-17210799_3",
"entity_ids": [
"PMID-17210799_T46",
... | [
{
"id": "PMID-17210799_R1",
"type": "frag",
"arg1_id": "PMID-17210799_T11",
"arg2_id": "PMID-17210799_T12",
"normalized": []
},
{
"id": "PMID-17210799_R2",
"type": "frag",
"arg1_id": "PMID-17210799_T83",
"arg2_id": "PMID-17210799_T26",
"normalized": []
}
] |
78 | PMID-19318806 | [
{
"id": "PMID-19318806__text",
"type": "abstract",
"text": [
"The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis.\n\nThe transformation of normal melanocytes, or melanocyte stem cells, to melanoma, is a complex process involving multiple mechanisms. Loss of tumor suppressor pr... | [
{
"id": "PMID-19318806_T1",
"type": "Gene_or_gene_product",
"text": [
"semaphorin 7A"
],
"offsets": [
[
4,
17
]
],
"normalized": []
},
{
"id": "PMID-19318806_T2",
"type": "Gene_or_gene_product",
"text": [
"Plexin C1"
],
"off... | [
{
"id": "PMID-19318806_E9",
"type": "Development",
"trigger": {
"text": [
"progression"
],
"offsets": [
[
537,
548
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19318806_T10"
}
]
},
... | [
{
"id": "PMID-19318806_1",
"entity_ids": [
"PMID-19318806_T14",
"PMID-19318806_T15"
]
}
] | [] |
79 | PMID-16406676 | [
{
"id": "PMID-16406676__text",
"type": "abstract",
"text": [
"Regulation of tumor angiogenesis by thrombospondin-1.\n\nAngiogenesis plays a critical role in the growth and metastasis of tumors. Thrombospondin-1 (TSP-1) is a potent angiogenesis inhibitor, and down-regulation of TSP-1 has been sugge... | [
{
"id": "PMID-16406676_T2",
"type": "Pathological_formation",
"text": [
"tumor"
],
"offsets": [
[
14,
19
]
],
"normalized": []
},
{
"id": "PMID-16406676_T4",
"type": "Gene_or_gene_product",
"text": [
"thrombospondin-1"
],
"o... | [
{
"id": "PMID-16406676_E12",
"type": "Negative_regulation",
"trigger": {
"text": [
"down-regulation"
],
"offsets": [
[
195,
210
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16406676_T13"
}... | [
{
"id": "PMID-16406676_1",
"entity_ids": [
"PMID-16406676_T38",
"PMID-16406676_T39"
]
},
{
"id": "PMID-16406676_2",
"entity_ids": [
"PMID-16406676_T8",
"PMID-16406676_T9"
]
}
] | [] |
80 | PMID-19514363 | [
{
"id": "PMID-19514363__text",
"type": "abstract",
"text": [
"[Role of the tumor suppressor ARF in oncogenesis]\n\nThe paper reviews the data available in the literature on a role of the tumor suppressor ARF in oncogenesis and considers the structure of a gene encoding ARF protein. The p53-depende... | [
{
"id": "PMID-19514363_T1",
"type": "Pathological_formation",
"text": [
"tumor"
],
"offsets": [
[
13,
18
]
],
"normalized": []
},
{
"id": "PMID-19514363_T2",
"type": "Gene_or_gene_product",
"text": [
"ARF"
],
"offsets": [
... | [
{
"id": "PMID-19514363_E13",
"type": "Negative_regulation",
"trigger": {
"text": [
"inactivation"
],
"offsets": [
[
587,
599
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19514363_T14"
}
... | [] | [] |
81 | PMID-12414659 | [
{
"id": "PMID-12414659__text",
"type": "abstract",
"text": [
"Roles of cell adhesion molecules in tumor angiogenesis induced by cotransplantation of cancer and endothelial cells to nude rats.\n\nRoles of cell adhesion molecules mediating the interaction of cancer and endothelial cells in tumor ang... | [
{
"id": "PMID-12414659_T2",
"type": "Pathological_formation",
"text": [
"tumor"
],
"offsets": [
[
36,
41
]
],
"normalized": []
},
{
"id": "PMID-12414659_T6",
"type": "Cell",
"text": [
"cancer"
],
"offsets": [
[
... | [
{
"id": "PMID-12414659_E5",
"type": "Planned_process",
"trigger": {
"text": [
"cotransplantation"
],
"offsets": [
[
66,
83
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12414659_T1000"
},
... | [
{
"id": "PMID-12414659_1",
"entity_ids": [
"PMID-12414659_T21",
"PMID-12414659_T22"
]
}
] | [
{
"id": "PMID-12414659_R1",
"type": "frag",
"arg1_id": "PMID-12414659_T10",
"arg2_id": "PMID-12414659_T11",
"normalized": []
},
{
"id": "PMID-12414659_R2",
"type": "frag",
"arg1_id": "PMID-12414659_T6",
"arg2_id": "PMID-12414659_T7",
"normalized": []
},
{
"id": "P... |
82 | PMID-16221381 | [
{
"id": "PMID-16221381__text",
"type": "abstract",
"text": [
"The merits of vascular targeting for gynecologic malignancies.\n\nNeovascularization is an early and critical step in tumor development and progression. Tumor vessels are distinct from their normal counterparts morphologically as well a... | [
{
"id": "PMID-16221381_T4",
"type": "Pathological_formation",
"text": [
"tumor"
],
"offsets": [
[
116,
121
]
],
"normalized": []
},
{
"id": "PMID-16221381_T5",
"type": "Multi-tissue_structure",
"text": [
"Tumor vessels"
],
"... | [
{
"id": "PMID-16221381_E2",
"type": "Development",
"trigger": {
"text": [
"progression"
],
"offsets": [
[
138,
149
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16221381_T4"
}
]
},
... | [] | [] |
83 | PMID-17488804 | [
{
"id": "PMID-17488804__text",
"type": "abstract",
"text": [
"Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.\n\nFrequent coffee consumption has been associate... | [
{
"id": "PMID-17488804_T2",
"type": "Drug_or_compound",
"text": [
"Caffeine"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "PMID-17488804_T4",
"type": "Drug_or_compound",
"text": [
"adenosine"
],
"offsets": [
... | [
{
"id": "PMID-17488804_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibits"
],
"offsets": [
[
9,
17
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-17488804_T2"
},
{
... | [
{
"id": "PMID-17488804_1",
"entity_ids": [
"PMID-17488804_T60",
"PMID-17488804_T61"
]
},
{
"id": "PMID-17488804_2",
"entity_ids": [
"PMID-17488804_T22",
"PMID-17488804_T23"
]
},
{
"id": "PMID-17488804_3",
"entity_ids": [
"PMID-17488804_T15",
... | [
{
"id": "PMID-17488804_R1",
"type": "frag",
"arg1_id": "PMID-17488804_T57",
"arg2_id": "PMID-17488804_T60",
"normalized": []
},
{
"id": "PMID-17488804_R2",
"type": "frag",
"arg1_id": "PMID-17488804_T58",
"arg2_id": "PMID-17488804_T61",
"normalized": []
}
] |
84 | PMID-18537682 | [
{
"id": "PMID-18537682__text",
"type": "abstract",
"text": [
"Research advances of endostatin and its short internal fragments.\n\nEndostatin, the C-terminal fragment of collagen XVIII, is a potent angiogenesis inhibitor. At present, there are a large number of research papers on endostatin. Howev... | [
{
"id": "PMID-18537682_T1",
"type": "Gene_or_gene_product",
"text": [
"endostatin"
],
"offsets": [
[
21,
31
]
],
"normalized": []
},
{
"id": "PMID-18537682_T2",
"type": "Gene_or_gene_product",
"text": [
"Endostatin"
],
"offs... | [
{
"id": "PMID-18537682_E1",
"type": "Blood_vessel_development",
"trigger": {
"text": [
"angiogenesis"
],
"offsets": [
[
134,
146
]
]
},
"arguments": []
},
{
"id": "PMID-18537682_E2",
"type": "Blood_vessel_development... | [] | [] |
85 | PMID-2255190 | [
{
"id": "PMID-2255190__text",
"type": "abstract",
"text": [
"Expression of basic fibroblast growth factor in normal human tissues.\n\nThe distribution of basic fibroblast growth factor (bFGF) was studied immunohistochemically in fresh frozen sections of normal human tissues. Immunodetection was pe... | [
{
"id": "PMID-2255190_T2",
"type": "Gene_or_gene_product",
"text": [
"basic fibroblast growth factor"
],
"offsets": [
[
14,
44
]
],
"normalized": []
},
{
"id": "PMID-2255190_T3",
"type": "Tissue",
"text": [
"tissues"
],
"off... | [
{
"id": "PMID-2255190_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"Expression"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-2255190_T2"
}
]
},
{
... | [
{
"id": "PMID-2255190_1",
"entity_ids": [
"PMID-2255190_T5",
"PMID-2255190_T6"
]
}
] | [
{
"id": "PMID-2255190_R1",
"type": "frag",
"arg1_id": "PMID-2255190_T20",
"arg2_id": "PMID-2255190_T21",
"normalized": []
}
] |
86 | PMID-18669910 | [
{
"id": "PMID-18669910__text",
"type": "abstract",
"text": [
"Allogeneic injection of fetal membrane-derived mesenchymal stem cells induces therapeutic angiogenesis in a rat model of hind limb ischemia.\n\nBone marrow-derived mesenchymal stem cells (BM-MSC) have been demonstrated to be an attracti... | [
{
"id": "PMID-18669910_T2",
"type": "Cell",
"text": [
"fetal membrane-derived mesenchymal stem cells"
],
"offsets": [
[
24,
69
]
],
"normalized": []
},
{
"id": "PMID-18669910_T6",
"type": "Organism_subdivision",
"text": [
"hind limb... | [
{
"id": "PMID-18669910_E1",
"type": "Planned_process",
"trigger": {
"text": [
"injection"
],
"offsets": [
[
11,
20
]
]
},
"arguments": [
{
"role": "Instrument",
"ref_id": "PMID-18669910_T2"
}
]
... | [
{
"id": "PMID-18669910_1",
"entity_ids": [
"PMID-18669910_T7",
"PMID-18669910_T9"
]
},
{
"id": "PMID-18669910_2",
"entity_ids": [
"PMID-18669910_T11",
"PMID-18669910_T12"
]
},
{
"id": "PMID-18669910_3",
"entity_ids": [
"PMID-18669910_T13",
... | [] |
87 | PMID-19758109 | [
{
"id": "PMID-19758109__text",
"type": "abstract",
"text": [
"AVE8062: a new combretastatin derivative vascular disrupting agent.\n\nAngiogenesis has an essential role in promoting and supporting tumor growth and it is an important therapeutic target. The tumor vascular network is the result of pr... | [
{
"id": "PMID-19758109_T1",
"type": "Drug_or_compound",
"text": [
"AVE8062"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "PMID-19758109_T2",
"type": "Multi-tissue_structure",
"text": [
"vascular"
],
"offsets": [
... | [
{
"id": "PMID-19758109_E5",
"type": "Positive_regulation",
"trigger": {
"text": [
"supporting"
],
"offsets": [
[
121,
131
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19758109_E7"
}
]
... | [
{
"id": "PMID-19758109_1",
"entity_ids": [
"PMID-19758109_T25",
"PMID-19758109_T28"
]
},
{
"id": "PMID-19758109_2",
"entity_ids": [
"PMID-19758109_T19",
"PMID-19758109_T21"
]
},
{
"id": "PMID-19758109_3",
"entity_ids": [
"PMID-19758109_T50",
... | [] |
88 | PMID-1869637 | [
{
"id": "PMID-1869637__text",
"type": "abstract",
"text": [
"Intracerebral grafting of cultured autologous skin fibroblasts into the rat striatum: an assessment of graft size and ultrastructure.\n\nTo identify a suitable donor cell population for gene therapy applications to the central nervous sy... | [
{
"id": "PMID-1869637_T2",
"type": "Cell",
"text": [
"skin fibroblasts"
],
"offsets": [
[
46,
62
]
],
"normalized": []
},
{
"id": "PMID-1869637_T3",
"type": "Multi-tissue_structure",
"text": [
"striatum"
],
"offsets": [
... | [
{
"id": "PMID-1869637_E1",
"type": "Planned_process",
"trigger": {
"text": [
"Intracerebral grafting"
],
"offsets": [
[
0,
22
]
]
},
"arguments": [
{
"role": "Instrument",
"ref_id": "PMID-1869637_T2"
... | [] | [] |
89 | PMID-17981770 | [
{
"id": "PMID-17981770__text",
"type": "abstract",
"text": [
"Role of telomeres in vascular senescence.\n\nTelomeres are DNA regions composed of TTAGGG repeats that are located at the ends of chromosomes. Specific proteins associate with the telomeres and form non-nucleosomal DNA-protein complexes... | [
{
"id": "PMID-17981770_T3",
"type": "Cellular_component",
"text": [
"chromosomes"
],
"offsets": [
[
128,
139
]
],
"normalized": []
},
{
"id": "PMID-17981770_T5",
"type": "Cellular_component",
"text": [
"chromosome"
],
"offse... | [
{
"id": "PMID-17981770_E1",
"type": "Breakdown",
"trigger": {
"text": [
"dysfunction"
],
"offsets": [
[
607,
618
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-17981770_T9"
}
]
},
{
... | [] | [] |
90 | PMID-10752531 | [
{
"id": "PMID-10752531__text",
"type": "abstract",
"text": [
"Vascular proliferation and enhanced expression of endothelial nitric oxide synthase in human peritoneum exposed to long-term peritoneal dialysis.\n\nLong-term peritoneal dialysis (PD) is associated with alterations in peritoneal permeab... | [
{
"id": "PMID-10752531_T3",
"type": "Multi-tissue_structure",
"text": [
"Vascular"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "PMID-10752531_T5",
"type": "Gene_or_gene_product",
"text": [
"endothelial nitric oxide synth... | [
{
"id": "PMID-10752531_E2",
"type": "Development",
"trigger": {
"text": [
"proliferation"
],
"offsets": [
[
9,
22
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10752531_T3"
}
]
},
{... | [
{
"id": "PMID-10752531_1",
"entity_ids": [
"PMID-10752531_T9",
"PMID-10752531_T8"
]
},
{
"id": "PMID-10752531_2",
"entity_ids": [
"PMID-10752531_T30",
"PMID-10752531_T31"
]
}
] | [] |
91 | PMID-17532651 | [
{
"id": "PMID-17532651__text",
"type": "abstract",
"text": [
"Medical therapy for intermittent claudication.\n\nMedical therapy to improve symptoms, stabilise the underlying vascular disease and improve lower limb outcomes is an important and effective adjunct to lifestyle modification and surgica... | [
{
"id": "PMID-17532651_T2",
"type": "Organism_subdivision",
"text": [
"lower limb"
],
"offsets": [
[
139,
149
]
],
"normalized": []
},
{
"id": "PMID-17532651_T3",
"type": "Gene_or_gene_product",
"text": [
"phosphodiesterase III"
... | [
{
"id": "PMID-17532651_E1",
"type": "Planned_process",
"trigger": {
"text": [
"treated"
],
"offsets": [
[
722,
729
]
]
},
"arguments": [
{
"role": "Instrument",
"ref_id": "PMID-17532651_T5"
},
{... | [] | [] |
92 | PMID-1377534 | [
{
"id": "PMID-1377534__text",
"type": "abstract",
"text": [
"Angiogenesis--biomedical technology.\n\nAll of these studies show that angiogenesis research can benefit from new biomedical technology tools currently being developed, as well as contribute by providing new technologies that can be used... | [] | [
{
"id": "PMID-1377534_E1",
"type": "Blood_vessel_development",
"trigger": {
"text": [
"angiogenesis"
],
"offsets": [
[
69,
81
]
]
},
"arguments": []
},
{
"id": "PMID-1377534_E2",
"type": "Blood_vessel_development",
... | [] | [] |
93 | PMID-19637749 | [
{
"id": "PMID-19637749__text",
"type": "abstract",
"text": [
"[Ambiguity role of neutrophils in oncogenesis]\n\nThe review is focused on the participation of polymorphonuclear granulocytes (neutrophils) in development and spreading of a tumor. We consider both the well known functions of neutrophi... | [
{
"id": "PMID-19637749_T1",
"type": "Cell",
"text": [
"neutrophils"
],
"offsets": [
[
19,
30
]
],
"normalized": []
},
{
"id": "PMID-19637749_T2",
"type": "Cell",
"text": [
"polymorphonuclear granulocytes"
],
"offsets": [
... | [
{
"id": "PMID-19637749_E1",
"type": "Development",
"trigger": {
"text": [
"development"
],
"offsets": [
[
142,
153
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19637749_T4"
}
]
},
... | [
{
"id": "PMID-19637749_1",
"entity_ids": [
"PMID-19637749_T13",
"PMID-19637749_T14"
]
}
] | [] |
94 | PMID-19118244 | [
{
"id": "PMID-19118244__text",
"type": "abstract",
"text": [
"Involvement of PTEN promoter methylation in cerebral cavernous malformations.\n\nBACKGROUND AND PURPOSE: Cerebral cavernous malformations (CCMs) are prevalent cerebral vascular lesions involving aberrant angiogenesis. However, the under... | [
{
"id": "PMID-19118244_T2",
"type": "Gene_or_gene_product",
"text": [
"PTEN"
],
"offsets": [
[
15,
19
]
],
"normalized": []
},
{
"id": "PMID-19118244_T4",
"type": "Gene_or_gene_product",
"text": [
"Phosphatase and tension homolog de... | [
{
"id": "PMID-19118244_E1",
"type": "DNA_methylation",
"trigger": {
"text": [
"methylation"
],
"offsets": [
[
29,
40
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19118244_T2"
},
{
... | [
{
"id": "PMID-19118244_1",
"entity_ids": [
"PMID-19118244_T4",
"PMID-19118244_T5"
]
},
{
"id": "PMID-19118244_2",
"entity_ids": [
"PMID-19118244_T56",
"PMID-19118244_T65"
]
}
] | [
{
"id": "PMID-19118244_R1",
"type": "frag",
"arg1_id": "PMID-19118244_T63",
"arg2_id": "PMID-19118244_T43",
"normalized": []
},
{
"id": "PMID-19118244_R2",
"type": "frag",
"arg1_id": "PMID-19118244_T64",
"arg2_id": "PMID-19118244_T47",
"normalized": []
}
] |
95 | PMID-18996355 | [
{
"id": "PMID-18996355__text",
"type": "abstract",
"text": [
"A novel integrin alpha5beta1 antagonistic peptide, A5-1, screened by Protein Chip system as a potent angiogenesis inhibitor.\n\nIntegrin alpha5beta1 immobilized on a ProteoChip was used to screen new antagonistic peptides from multiple ... | [
{
"id": "PMID-18996355_T1",
"type": "Gene_or_gene_product",
"text": [
"integrin alpha5beta1"
],
"offsets": [
[
8,
28
]
],
"normalized": []
},
{
"id": "PMID-18996355_T2",
"type": "Gene_or_gene_product",
"text": [
"A5-1"
],
"o... | [
{
"id": "PMID-18996355_E6",
"type": "Binding",
"trigger": {
"text": [
"interaction"
],
"offsets": [
[
375,
386
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-18996355_T8"
},
{
... | [
{
"id": "PMID-18996355_1",
"entity_ids": [
"PMID-18996355_T10",
"PMID-18996355_T11"
]
}
] | [] |
96 | PMID-17040495 | [
{
"id": "PMID-17040495__text",
"type": "abstract",
"text": [
"Collagen-poly glycolic acid hybrid matrix with basic fibroblast growth factor accelerated angiogenesis and granulation tissue formation in diabetic mice.\n\nBecause poor skin wound healing associated with diabetes is thought to be partl... | [
{
"id": "PMID-17040495_T2",
"type": "Gene_or_gene_product",
"text": [
"Collagen"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "PMID-17040495_T3",
"type": "Drug_or_compound",
"text": [
"poly glycolic acid"
],
"offs... | [
{
"id": "PMID-17040495_E7",
"type": "Development",
"trigger": {
"text": [
"formation"
],
"offsets": [
[
126,
135
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-17040495_T9"
}
]
},
{
... | [] | [] |
97 | PMID-16556061 | [
{
"id": "PMID-16556061__text",
"type": "abstract",
"text": [
"Circulating endothelial cells in malignant disease.\n\nCancer is a disease largely dependent on neoangiogenesis. Cancer neoangiogenesis is often disordered and abnormal, with evidence of coexisting vascular endothelial dysfunction. A no... | [
{
"id": "PMID-16556061_T1",
"type": "Cell",
"text": [
"endothelial cells"
],
"offsets": [
[
12,
29
]
],
"normalized": []
},
{
"id": "PMID-16556061_T5",
"type": "Tissue",
"text": [
"vascular endothelial"
],
"offsets": [
... | [
{
"id": "PMID-16556061_E19",
"type": "Breakdown",
"trigger": {
"text": [
"damage"
],
"offsets": [
[
617,
623
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16556061_T21"
}
]
},
{
... | [
{
"id": "PMID-16556061_1",
"entity_ids": [
"PMID-16556061_T16",
"PMID-16556061_T17"
]
},
{
"id": "PMID-16556061_2",
"entity_ids": [
"PMID-16556061_T11",
"PMID-16556061_T12"
]
},
{
"id": "PMID-16556061_3",
"entity_ids": [
"PMID-16556061_T27",
... | [] |
98 | PMID-19481797 | [
{
"id": "PMID-19481797__text",
"type": "abstract",
"text": [
"Promoting angiogenesis via manipulation of VEGF responsiveness with notch signaling.\n\nPromoting angiogenesis via delivery of vascular endothelial growth factor (VEGF) and other angiogenic factors is both a potential therapy for cardio... | [
{
"id": "PMID-19481797_T5",
"type": "Gene_or_gene_product",
"text": [
"VEGF"
],
"offsets": [
[
43,
47
]
],
"normalized": []
},
{
"id": "PMID-19481797_T10",
"type": "Gene_or_gene_product",
"text": [
"vascular endothelial growth facto... | [
{
"id": "PMID-19481797_E3",
"type": "Regulation",
"trigger": {
"text": [
"manipulation"
],
"offsets": [
[
27,
39
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19481797_T5"
},
{
... | [
{
"id": "PMID-19481797_1",
"entity_ids": [
"PMID-19481797_T10",
"PMID-19481797_T11"
]
}
] | [] |
99 | PMID-14604834 | [
{
"id": "PMID-14604834__text",
"type": "abstract",
"text": [
"Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels.\n\nThe vascular insulin-like growth factor (IGF)-1 system includes the IGFs, the IGF-1 receptor (IGF-1R), and multiple binding proteins.... | [
{
"id": "PMID-14604834_T1",
"type": "Gene_or_gene_product",
"text": [
"IGF-1"
],
"offsets": [
[
40,
45
]
],
"normalized": []
},
{
"id": "PMID-14604834_T2",
"type": "Gene_or_gene_product",
"text": [
"IGF-1R"
],
"offsets": [
... | [
{
"id": "PMID-14604834_E24",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
"offsets": [
[
1242,
1252
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-14604834_T25"
}
]
... | [
{
"id": "PMID-14604834_1",
"entity_ids": [
"PMID-14604834_T8",
"PMID-14604834_T9"
]
}
] | [] |
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