id stringlengths 9 10 | document_id stringlengths 6 8 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
example-0 | 10335724 | [
{
"id": "passage-0",
"type": "abstract",
"text": [
" Serial measurements of antineutrophil cytoplasmic autoantibodies in patients with systemic vasculitis. PURPOSE: To assess the value of serial determinations of antineutrophil cytoplasmic autoantibodies (ANCA) for monitoring disease act... | [] | [] | [] | [] |
example-1 | 9719587 | [
{
"id": "passage-1",
"type": "abstract",
"text": [
"The synthesis of a range of 3-hydroxy-4(1H)-pyridinones with potential for the chelation of iron(III) is described. The pKa values of respective ligands and the stability constants of their iron(III) complexes are presented. The distribution coef... | [
{
"id": "entity-1-0",
"type": "IUPAC",
"text": [
"3-hydroxy-4(1H)-pyridinones"
],
"offsets": [
[
28,
55
]
],
"normalized": []
},
{
"id": "entity-1-1",
"type": "TRIVIAL",
"text": [
"iron(III)"
],
"offsets": [
[
... | [] | [] | [] |
example-2 | 3625710 | [
{
"id": "passage-2",
"type": "abstract",
"text": [
"A series of analogues of the analgesic dipeptide derivative H-Lys-Trp(NPS)-OMe has been designed to determine the influence of the (2-nitrophenyl)sulfenyl (NPS) moiety on the activity. The syntheses and antinociceptive effects of these analogues ... | [
{
"id": "entity-2-0",
"type": "",
"text": [
"H-Lys-Trp(NPS)-OMe"
],
"offsets": [
[
60,
78
]
],
"normalized": []
},
{
"id": "entity-2-1",
"type": "PARTIUPAC",
"text": [
"(2-nitrophenyl)sulfenyl"
],
"offsets": [
[
... | [] | [] | [] |
example-3 | 2153828 | [
{
"id": "passage-3",
"type": "abstract",
"text": [
"A series of substituted 1,4-dihydronaphthoquinones, hydroindoloquinones, benzofuran-4,7-dihydroquinones, and benzothiophene-4,7-dihydroquinones were synthesized and evaluated for inhibitory activity against 5-lipoxygenase. These compounds were fo... | [
{
"id": "entity-3-0",
"type": "IUPAC",
"text": [
"1,4-dihydronaphthoquinones"
],
"offsets": [
[
24,
50
]
],
"normalized": []
},
{
"id": "entity-3-1",
"type": "TRIVIAL",
"text": [
"hydroindoloquinones"
],
"offsets": [
[... | [] | [] | [] |
example-4 | 8817480 | [
{
"id": "passage-4",
"type": "abstract",
"text": [
" The regulation of total creatine content in a myoblast cell line. Total cellular creatine content is an important bioenergetic parameter in skeletal muscle. To understand its regulation we investigated creatine transport and accumulatio... | [
{
"id": "entity-4-0",
"type": "TRIVIAL",
"text": [
"creatine"
],
"offsets": [
[
33,
41
]
],
"normalized": []
},
{
"id": "entity-4-1",
"type": "TRIVIAL",
"text": [
"creatine"
],
"offsets": [
[
91,
99
... | [] | [] | [] |
example-5 | 12742193 | [
{
"id": "passage-5",
"type": "abstract",
"text": [
"12742193 Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. The aim of this study was to assess, firstly, if exclusion of central noradrenergic areas in the hypothalamus and brain stem with... | [
{
"id": "entity-5-0",
"type": "IUPAC",
"text": [
"clonidine hydrochloride"
],
"offsets": [
[
61,
84
]
],
"normalized": []
},
{
"id": "entity-5-1",
"type": "IUPAC",
"text": [
"clonidine hydrochloride"
],
"offsets": [
[
... | [] | [] | [] |
example-6 | 16682228 | [
{
"id": "passage-6",
"type": "abstract",
"text": [
"16682228 Heterologous expression of lipoprotein-associated phospholipase A2 in different expression systems. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a key enzyme involved in atherosclerosis, and has been considered as a new tar... | [] | [] | [] | [] |
example-7 | 10639285 | [
{
"id": "passage-7",
"type": "abstract",
"text": [
"A series of 2-(diethylamino)thieno1,3?xazin-4-ones was synthesized and evaluated in vitro for inhibitory activity toward human leukocyte elastase (HLE). The Gewald thiophene synthesis was utilized to obtain several ethyl 2-aminothiophene-3-carbox... | [
{
"id": "entity-7-0",
"type": "IUPAC",
"text": [
"2-(diethylamino)thieno1,3?xazin-4-ones"
],
"offsets": [
[
12,
50
]
],
"normalized": []
},
{
"id": "entity-7-1",
"type": "TRIVIAL",
"text": [
"thiophene"
],
"offsets": [
... | [] | [] | [] |
example-8 | 17371003 | [
{
"id": "passage-8",
"type": "abstract",
"text": [
"Structure-activity relationships have been investigated for inhibition of DNA-dependent protein kinase (DNA-PK) and ATM kinase by a series of pyran-2-ones, pyran-4-ones, thiopyran-4-ones, and pyridin-4-ones. A wide range of IC50 values were obser... | [
{
"id": "entity-8-0",
"type": "FAMILY",
"text": [
"pyran-2-ones"
],
"offsets": [
[
142,
154
]
],
"normalized": []
},
{
"id": "entity-8-1",
"type": "FAMILY",
"text": [
"pyran-4-ones"
],
"offsets": [
[
156,
... | [] | [] | [] |
example-9 | 6780324 | [
{
"id": "passage-9",
"type": "abstract",
"text": [
" Differential effects of luteinizing hormone-releasing hormone on follicle-stimulating hormone-dependent responses in rat granulosa cells and Sertoli cells in vitro. The abilities of LHRH and a potent LHRH agonist ([D-Ser-(But),6, des-Gl... | [
{
"id": "entity-9-0",
"type": "",
"text": [
"[D-Ser-(But),6, des-Gly-NH210]LHRH ethylamide"
],
"offsets": [
[
224,
269
]
],
"normalized": []
},
{
"id": "entity-9-1",
"type": "TRIVIAL",
"text": [
"diethylstilbestrol"
],
"offs... | [] | [] | [] |
example-10 | 12672235 | [
{
"id": "passage-10",
"type": "abstract",
"text": [
"We have previously described (RS)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid (4-AHCP) as a highly effective agonist at non-N-methyl-d-aspartate (non-NMDA) glutamate (Glu) receptors in vivo, which is more potent... | [
{
"id": "entity-10-0",
"type": "IUPAC",
"text": [
"(RS)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid"
],
"offsets": [
[
29,
111
]
],
"normalized": []
},
{
"id": "entity-10-1",
"type": "ABBREVIATION",
"text... | [] | [] | [] |
example-11 | 7205876 | [
{
"id": "passage-11",
"type": "abstract",
"text": [
"The synthesis of aminoaceto-2',6'-xylidides substituted on the amide nitrogen with 2-(diethylamino)ethyl, 2-aminoethyl, 2-hydroxyethyl, and 2-ethoxyethyl groups is described. The 2-aminoethyl derivatives were prepared by treatment of N-(2-phthal... | [
{
"id": "entity-11-0",
"type": "IUPAC",
"text": [
"aminoaceto-2',6'-xylidides"
],
"offsets": [
[
17,
43
]
],
"normalized": []
},
{
"id": "entity-11-1",
"type": "MODIFIER",
"text": [
"substituted"
],
"offsets": [
[
... | [] | [] | [] |
example-12 | 2104934 | [
{
"id": "passage-12",
"type": "abstract",
"text": [
"Some novel 6-fluoro-7-substituted-1,4-dihydro-4-oxoquinoline-3-carboxylic acids have been prepared. At the N-1 position \"standard\" substitution was employed with the ethyl, cyclopropyl, and p-fluorophenyl groups being used. At C-7 the introduc... | [
{
"id": "entity-12-0",
"type": "IUPAC",
"text": [
"6-fluoro-7-substituted-1,4-dihydro-4-oxoquinoline-3-carboxylic acids"
],
"offsets": [
[
11,
79
]
],
"normalized": []
},
{
"id": "entity-12-1",
"type": "PARTIUPAC",
"text": [
"ethyl"... | [] | [] | [] |
example-13 | 2329575 | [
{
"id": "passage-13",
"type": "abstract",
"text": [
"The thermal Fischer indolization of hydrazones resulting from 4-hydrazino-5-methyl-1H-pyridin-2-one and various beta- and alpha-tetralones led to 4-methyl-6,7-dihydro-2H,5H-pyrido[4,3- b]benzo[e]indol-1-ones and 4-methyl-11-dihydro-2H,5H-pyrido[... | [
{
"id": "entity-13-0",
"type": "FAMILY",
"text": [
"hydrazones"
],
"offsets": [
[
36,
46
]
],
"normalized": []
},
{
"id": "entity-13-1",
"type": "IUPAC",
"text": [
"4-hydrazino-5-methyl-1H-pyridin-2-one"
],
"offsets": [
... | [] | [] | [] |
example-14 | 596853 | [
{
"id": "passage-14",
"type": "abstract",
"text": [
"596853 [Synthesis and properties of carminomycinone derivatives] The possibility of chemical modification of carminomycinone-aglycone (II) of carminomicin, a side product in the antibiotic production was studied. The methyl group C-14 was func... | [
{
"id": "entity-14-0",
"type": "TRIVIAL",
"text": [
"carminomycinone"
],
"offsets": [
[
37,
52
]
],
"normalized": []
},
{
"id": "entity-14-1",
"type": "MODIFIER",
"text": [
"derivatives"
],
"offsets": [
[
53,
... | [] | [] | [] |
example-15 | 7040662 | [
{
"id": "passage-15",
"type": "abstract",
"text": [
"Adenosine 5'-triphosphate (ATP) derivatives of the types N6-R-ATP [R = (CH2)nNHCOCH2I, (CH2)nNHCO-(CH2)mNHCOCH2I, or (CH2)nCON(Me)(CH2)mN(Me)CO(CH2)nNHCOCH2I], N6-Me-N6-R-ATP [R = (CH2)nN-(Me)CO(CH2)mNHCOCH2I], and 8-R-ATP [R = NM(CH2)nNHCOCH2I]... | [
{
"id": "entity-15-0",
"type": "ABBREVIATION",
"text": [
"ATP"
],
"offsets": [
[
27,
30
]
],
"normalized": []
},
{
"id": "entity-15-1",
"type": "MODIFIER",
"text": [
"derivatives"
],
"offsets": [
[
32,
... | [] | [] | [] |
example-16 | 2944474 | [
{
"id": "passage-16",
"type": "abstract",
"text": [
"2944474 Effect of recombinant human fibroblast interferon and mezerein on growth, differentiation, immune interferon binding and tumor associated antigen expression in human melanoma cells. The combination of recombinant human fibroblast inter... | [
{
"id": "entity-16-0",
"type": "TRIVIAL",
"text": [
"mezerein"
],
"offsets": [
[
63,
71
]
],
"normalized": []
},
{
"id": "entity-16-1",
"type": "TRIVIAL",
"text": [
"mezerein"
],
"offsets": [
[
293,
301... | [] | [] | [] |
example-17 | 16033265 | [
{
"id": "passage-17",
"type": "abstract",
"text": [
"Degarelix (FE200486, Ac-d-2Nal(1)-d-4Cpa(2)-d-3Pal(3)-Ser(4)-4Aph(l-Hor)(5)-d-4Aph(Cbm)(6)-Leu(7)-ILys(8)-Pro(9)-d-Ala( )-NH(2)) is a potent and very long acting antagonist of gonadotropin-releasing hormone (GnRH) after subcutaneous administrat... | [
{
"id": "entity-17-0",
"type": "TRIVIALVAR",
"text": [
"FE200486"
],
"offsets": [
[
11,
19
]
],
"normalized": []
},
{
"id": "entity-17-1",
"type": "",
"text": [
"Ac-d-2Nal(1)-d-4Cpa(2)-d-3Pal(3)-Ser(4)-4Aph(l-Hor)(5)-d-4Aph(Cbm)(6)-... | [] | [] | [] |
example-18 | 16329601 | [
{
"id": "passage-18",
"type": "abstract",
"text": [
" [Method of determination of biogenic amines in wines by high-performance liquid chromatography with fluorescence detector and ultraviolet detector] OBJECTIVE: A pre-column derivation reversed-phase high-performance liquid chromatograp... | [
{
"id": "entity-18-0",
"type": "FAMILY",
"text": [
"amines"
],
"offsets": [
[
47,
53
]
],
"normalized": []
},
{
"id": "entity-18-1",
"type": "TRIVIAL",
"text": [
"tryptamine"
],
"offsets": [
[
311,
321
... | [] | [] | [] |
example-19 | 3656362 | [
{
"id": "passage-19",
"type": "abstract",
"text": [
"The isomeric 4-(3-chloro-4-hydroxyphenyl)- and 4-(4-chloro-3-hydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines, the N-methyl derivative of the 4-(4-chloro-3-hydroxyphenyl) isomer, and 4-(3-hydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline were synthesi... | [
{
"id": "entity-19-0",
"type": "PARTIUPAC",
"text": [
"4-(3-chloro-4-hydroxyphenyl)-"
],
"offsets": [
[
13,
42
]
],
"normalized": []
},
{
"id": "entity-19-1",
"type": "IUPAC",
"text": [
"4-(4-chloro-3-hydroxyphenyl)-1,2,3,4-tetrahyd... | [] | [] | [] |
example-20 | 14998335 | [
{
"id": "passage-20",
"type": "abstract",
"text": [
"In a continuing effort to design small-molecule inhibitors of dihydrofolate reductase (DHFR) that combine the enzyme-binding selectivity of 2,4-diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine (trimethoprim, TMP) with the potency of 2,4-diamino-5... | [
{
"id": "entity-20-0",
"type": "IUPAC",
"text": [
"2,4-diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine"
],
"offsets": [
[
140,
191
]
],
"normalized": []
},
{
"id": "entity-20-1",
"type": "TRIVIAL",
"text": [
"trimethoprim"
],
... | [] | [] | [] |
example-21 | 9120816 | [
{
"id": "passage-21",
"type": "abstract",
"text": [
" Parenteral hydroxypropyl cyclodextrins: intravenous and intracerebral administration of lipophiles. Hydroxypropyl cyclodextrins are nontoxic carbohydrate derivatives of moderate molecular weight ( Da) which form water-soluble ... | [
{
"id": "entity-21-0",
"type": "IUPAC",
"text": [
"hydroxypropyl cyclodextrins"
],
"offsets": [
[
20,
47
]
],
"normalized": []
},
{
"id": "entity-21-1",
"type": "IUPAC",
"text": [
"Hydroxypropyl cyclodextrins"
],
"offsets": ... | [] | [] | [] |
example-22 | 6264792 | [
{
"id": "passage-22",
"type": "abstract",
"text": [
"6264792 Inhibition of renin secretion by intrarenal alpha-adrenoceptor blockade. This study was designed to determine whether renal alpha-adrenoceptors can mediate tonic neural stimulation of renin secretion. The effect of alpha-adrenoceptor b... | [
{
"id": "entity-22-0",
"type": "TRIVIAL",
"text": [
"phenoxybenzamine"
],
"offsets": [
[
256,
272
]
],
"normalized": []
},
{
"id": "entity-22-1",
"type": "ABBREVIATION",
"text": [
"POB"
],
"offsets": [
[
274,
... | [] | [] | [] |
example-23 | 5808825 | [
{
"id": "passage-23",
"type": "abstract",
"text": [
" Metabolism of D- and L-glyceraldehyde in adipose tissue: a stereochemical probe for glycerokinase activity. Distributions of (14)C have been determined in free glycerol, in glycerol from triglycerides, in glucose from glycogen, and in ... | [
{
"id": "entity-23-0",
"type": "IUPAC",
"text": [
"D-"
],
"offsets": [
[
23,
25
]
],
"normalized": []
},
{
"id": "entity-23-1",
"type": "IUPAC",
"text": [
"L-glyceraldehyde"
],
"offsets": [
[
30,
46
... | [] | [] | [] |
example-24 | 12553880 | [
{
"id": "passage-24",
"type": "abstract",
"text": [
" Attenuation of glucocorticoid functions in an Anx-A1-/- cell line. The Ca(2+)- and phospholipid-binding protein Anx-A1 (annexin 1; lipocortin 1) has been described both as an inhibitor of phospholipase A(2) (PLA(2)) activity and as a ... | [
{
"id": "entity-24-0",
"type": "FAMILY",
"text": [
"glucocorticoid"
],
"offsets": [
[
25,
39
]
],
"normalized": []
},
{
"id": "entity-24-1",
"type": "FAMILY",
"text": [
"glucocorticoid"
],
"offsets": [
[
257,
... | [] | [] | [] |
example-25 | 14591846 | [
{
"id": "passage-25",
"type": "abstract",
"text": [
"14591846 Cognitive assessment of geriatric schizophrenic patients with severe impairment. There is evidence that some elderly patients with chronic schizophrenia experience marked impairments in cognitive functioning. Assessment of these patie... | [] | [] | [] | [] |
example-26 | 721701 | [
{
"id": "passage-26",
"type": "abstract",
"text": [
" Evidence for messenger ribonucleic acid of an ammonium-inducible glutamate dehydrogenase and synthesis, covalent modification, and degradation of enzyme subunits in uninduced Chlorella sorokiniana cells. The cells of Chlorella sorokini... | [
{
"id": "entity-26-0",
"type": "TRIVIAL",
"text": [
"nitrate"
],
"offsets": [
[
261,
268
]
],
"normalized": []
},
{
"id": "entity-26-1",
"type": "IUPAC",
"text": [
"polyadenylic acid"
],
"offsets": [
[
845,
... | [] | [] | [] |
example-27 | 1350435 | [
{
"id": "passage-27",
"type": "abstract",
"text": [
" Nucleotide regulation of heat-stable enterotoxin receptor binding and of guanylate cyclase activation. Certain nucleotides were found to regulate the binding of the Escherichia coli heat-stable enterotoxin (STa) to its receptor in pig ... | [
{
"id": "entity-27-0",
"type": "FAMILY",
"text": [
"Nucleotide"
],
"offsets": [
[
9,
19
]
],
"normalized": []
},
{
"id": "entity-27-1",
"type": "FAMILY",
"text": [
"nucleotides"
],
"offsets": [
[
121,
1... | [] | [] | [] |
example-28 | 6292417 | [
{
"id": "passage-28",
"type": "abstract",
"text": [
"The syntheses of (3RS,4RS)-4-hydroxypiperidine-3-carboxylic acid (4), (3RS,5SR)-5-hydroxypiperidine-3-carboxylic acid ( ), (3RS,4SR)-4-acetamidopiperidine-3-carboxylic acid ( ), and (3RS,5SR)-5-acetamidopiperidine-3-carboxylic acid (18), relat... | [
{
"id": "entity-28-0",
"type": "IUPAC",
"text": [
"(3RS,4RS)-4-hydroxypiperidine-3-carboxylic acid"
],
"offsets": [
[
17,
64
]
],
"normalized": []
},
{
"id": "entity-28-1",
"type": "IUPAC",
"text": [
"(3RS,5SR)-5-hydroxypiperidine-3... | [] | [] | [] |
example-29 | 16946562 | [
{
"id": "passage-29",
"type": "abstract",
"text": [
"16946562 Novel genetic variations and haplotypes of hepatocyte nuclear factor 4alpha (HNF4A) found in Japanese type II diabetic patients. Thirty-nine single nucleotide variations, including 16 novel ones, were found in the 5' promoter region, ... | [] | [] | [] | [] |
example-30 | 15620433 | [
{
"id": "passage-30",
"type": "abstract",
"text": [
" Predictive clinical parameters for therapeutic efficacy of rosiglitazone in Korean type 2 diabetes mellitus. This study evaluated the efficacy of rosiglitazone in non-obese and obese Korean type 2 diabetic patients of long duration. A... | [
{
"id": "entity-30-0",
"type": "TRIVIAL",
"text": [
"rosiglitazone"
],
"offsets": [
[
69,
82
]
],
"normalized": []
},
{
"id": "entity-30-1",
"type": "TRIVIAL",
"text": [
"rosiglitazone"
],
"offsets": [
[
157,
... | [] | [] | [] |
example-31 | 2231607 | [
{
"id": "passage-31",
"type": "abstract",
"text": [
"The synthesis of 2'-fluoro- -propargyl-5,8-dideazafolic acid and its 2-desamino, 2-desamino-2-hydroxymethyl, and 2-desamino-2-methoxy analogues is described. In general the synthetic route involved the coupling of diethyl N-[2-fluoro-4-(prop-2-... | [
{
"id": "entity-31-0",
"type": "IUPAC",
"text": [
"2'-fluoro-10-propargyl-5,8-dideazafolic acid"
],
"offsets": [
[
17,
61
]
],
"normalized": []
},
{
"id": "entity-31-1",
"type": "PARTIUPAC",
"text": [
"2-desamino"
],
"offset... | [] | [] | [] |
example-32 | 11985471 | [
{
"id": "passage-32",
"type": "abstract",
"text": [
"A novel class of 5-substituted acyclic pyrimidine nucleosides, 1-[(2-hydroxyethoxy)methyl]-5-(1-azidovinyl)uracil (9a), 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]-5-(1-azidovinyl)uracil (9b), and 1-[4-hydroxy-3-(hydroxymethyl)-1-butyl]-5-(1-a... | [
{
"id": "entity-32-0",
"type": "IUPAC",
"text": [
"5-substituted acyclic pyrimidine nucleosides"
],
"offsets": [
[
17,
61
]
],
"normalized": []
},
{
"id": "entity-32-1",
"type": "IUPAC",
"text": [
"1-[(2-hydroxyethoxy)methyl]-5-(1-a... | [] | [] | [] |
example-33 | 10813108 | [
{
"id": "passage-33",
"type": "abstract",
"text": [
" Antiestrogens reduce plasma levels of endothelin-1 without affecting nitrate levels in breast cancer patients. Tamoxifen protects against myocardial infarction through mechanisms that are poorly understood. We studied the effects of t... | [
{
"id": "entity-33-0",
"type": "IUPAC",
"text": [
"nitrate"
],
"offsets": [
[
79,
86
]
],
"normalized": []
},
{
"id": "entity-33-1",
"type": "TRIVIAL",
"text": [
"Tamoxifen"
],
"offsets": [
[
122,
131
... | [] | [] | [] |
example-34 | 2299637 | [
{
"id": "passage-34",
"type": "abstract",
"text": [
"A series of new 5-(1-hydroxy-2-iodoethyl)-2'-deoxyuridine and uridine compounds (11, 16) was synthesized by the regiospecific addition of HOI to the vinyl substituent of 5-vinyl-2'-deoxyuridine ( ), 5-vinyl-2'-fluoro-2'-deoxyuridine ( ), 5-v... | [
{
"id": "entity-34-0",
"type": "IUPAC",
"text": [
"5-(1-hydroxy-2-iodoethyl)-2'-deoxyuridine"
],
"offsets": [
[
16,
57
]
],
"normalized": []
},
{
"id": "entity-34-1",
"type": "TRIVIAL",
"text": [
"uridine"
],
"offsets": [
... | [] | [] | [] |
example-35 | 3735316 | [
{
"id": "passage-35",
"type": "abstract",
"text": [
"N-Methylacetazolamide was shown to be active topically in reducing intraocular pressure (IOP) to a small but statistically significant level in the normotensive rabbit eye. In vivo experiments with N-methylacetazolamide suggest that ocular metab... | [
{
"id": "entity-35-0",
"type": "IUPAC",
"text": [
"N-methylacetazolamide"
],
"offsets": [
[
198,
219
]
],
"normalized": []
},
{
"id": "entity-35-1",
"type": "TRIVIAL",
"text": [
"acetazolamide"
],
"offsets": [
[
... | [] | [] | [] |
example-36 | 6827523 | [
{
"id": "passage-36",
"type": "abstract",
"text": [
"Condensation of 14-bromodaunorubicin with thiols in methanol, in the presence of potassium carbonate, resulted in the formation of 14-thia analogues of the antitumor antibiotic adriamycin. However, similar condensation of N-(trifluoroacetyl)-14-... | [
{
"id": "entity-36-0",
"type": "IUPAC",
"text": [
"14-bromodaunorubicin"
],
"offsets": [
[
16,
36
]
],
"normalized": []
},
{
"id": "entity-36-1",
"type": "FAMILY",
"text": [
"thiols"
],
"offsets": [
[
42,
... | [] | [] | [] |
example-37 | 10783907 | [
{
"id": "passage-37",
"type": "abstract",
"text": [
" Enalapril in subantihypertensive dosage attenuates kidney proliferation and functional recovery in normotensive ablation nephropathy of the rat. Most studies on the antiproliferative action of angiotensin converting enzyme inhibitors ... | [
{
"id": "entity-37-0",
"type": "TRIVIAL",
"text": [
"Enalapril"
],
"offsets": [
[
10,
19
]
],
"normalized": []
},
{
"id": "entity-37-1",
"type": "TRIVIAL",
"text": [
"enalapril"
],
"offsets": [
[
616,
6... | [] | [] | [] |
example-38 | 9082041 | [
{
"id": "passage-38",
"type": "abstract",
"text": [
" Replacing dietary palmitic acid with elaidic acid (t-C18:1 delta9) depresses HDL and increases CETP activity in cebus monkeys. The question whether dietary trans fatty acids affect lipoprotein metabolism similarly to specific saturated... | [
{
"id": "entity-38-0",
"type": "IUPAC",
"text": [
"palmitic acid"
],
"offsets": [
[
27,
40
]
],
"normalized": []
},
{
"id": "entity-38-1",
"type": "IUPAC",
"text": [
"elaidic acid"
],
"offsets": [
[
46,
... | [] | [] | [] |
example-39 | 10447954 | [
{
"id": "passage-39",
"type": "abstract",
"text": [
"Radiolabeled m-iodobenzylguanidine (MIBG) is a tumor-seeking radioactive drug used in the diagnosis and treatment of pheochromocytomas and neuroblastomas. It is transported into the tumor cells by the neuronal norepinephrine (NE) transporter (NE... | [
{
"id": "entity-39-0",
"type": "IUPAC",
"text": [
"m-iodobenzylguanidine"
],
"offsets": [
[
13,
34
]
],
"normalized": []
},
{
"id": "entity-39-1",
"type": "ABBREVIATION",
"text": [
"MIBG"
],
"offsets": [
[
36,
... | [] | [] | [] |
example-40 | 11358723 | [
{
"id": "passage-40",
"type": "abstract",
"text": [
"11358723 Influence of estrogens on the androgen metabolism in different subunits of human hair follicles. The molecular pathways involved in estrogen-mediated induction of hair growth in androgenetic alopecia are unknown. Some authors found th... | [
{
"id": "entity-40-0",
"type": "FAMILY",
"text": [
"estrogens"
],
"offsets": [
[
23,
32
]
],
"normalized": []
},
{
"id": "entity-40-1",
"type": "FAMILY",
"text": [
"androgen"
],
"offsets": [
[
40,
48
... | [] | [] | [] |
example-41 | 12890682 | [
{
"id": "passage-41",
"type": "abstract",
"text": [
" Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells. Lysophosphatidate (LPA) mediates multiple cellular responses via heterot... | [
{
"id": "entity-41-0",
"type": "TRIVIAL",
"text": [
"lysophosphatidate"
],
"offsets": [
[
45,
62
]
],
"normalized": []
},
{
"id": "entity-41-1",
"type": "TRIVIAL",
"text": [
"Lysophosphatidate"
],
"offsets": [
[
... | [] | [] | [] |
example-42 | 2229079 | [
{
"id": "passage-42",
"type": "abstract",
"text": [
" Thyrotropin modulates low density lipoprotein binding activity in FRTL-5 thyroid cells. FRTL-5 cells possess high affinity low density lipoprotein (LDL) receptors which bind, internalize, and degrade LDL. When FRTL-5 cells are deprived... | [
{
"id": "entity-42-0",
"type": "IUPAC",
"text": [
"8-Br-cAMP"
],
"offsets": [
[
889,
898
]
],
"normalized": []
},
{
"id": "entity-42-1",
"type": "TRIVIAL",
"text": [
"cycloheximide"
],
"offsets": [
[
962,
... | [] | [] | [] |
example-43 | 8230102 | [
{
"id": "passage-43",
"type": "abstract",
"text": [
"In order to develop tracers with higher specific activity to supplant the currently used [3H]-8-OH-DPAT [8-hydroxy-2-(N,N-di-n-propylamino)tetralin] for in vitro and in vivo evaluation of 5-HT1A receptors, a new radioiodinated ligand was prepare... | [
{
"id": "entity-43-0",
"type": "IUPAC",
"text": [
"[3H]-8-OH-DPAT"
],
"offsets": [
[
89,
103
]
],
"normalized": []
},
{
"id": "entity-43-1",
"type": "IUPAC",
"text": [
"8-hydroxy-2-(N,N-di-n-propylamino)tetralin"
],
"offsets... | [] | [] | [] |
example-44 | 10479279 | [
{
"id": "passage-44",
"type": "abstract",
"text": [
"The synthesis and pharmacological profile of a series of neuroprotective adenosine agonists are described. Novel A(1) agonists with potent central nervous system effects and diminished influence on the cardiovascular system are reported and comp... | [
{
"id": "entity-44-0",
"type": "IUPAC",
"text": [
"2-chloro-N-(1-phenoxy-2-propyl)adenosine"
],
"offsets": [
[
376,
416
]
],
"normalized": []
},
{
"id": "entity-44-1",
"type": "TRIVIALVAR",
"text": [
"NNC 21-0041"
],
"offset... | [] | [] | [] |
example-45 | 1732554 | [
{
"id": "passage-45",
"type": "abstract",
"text": [
"A series of 8-(trifluoromethyl)-substituted quinolones has been prepared and evaluated for in vitro and in vivo antibacterial activity, and phototolerance in a mouse phototolerance assay. These analogues were compared to the corresponding series... | [
{
"id": "entity-45-0",
"type": "IUPAC",
"text": [
"8-(trifluoromethyl)-substituted quinolones"
],
"offsets": [
[
12,
54
]
],
"normalized": []
},
{
"id": "entity-45-1",
"type": "PARTIUPAC",
"text": [
"6,8-difluoro-"
],
"offse... | [] | [] | [] |
example-46 | 3761308 | [
{
"id": "passage-46",
"type": "abstract",
"text": [
"This study emphasizes the importance of the metabolic conversion of the enantiomers of 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) into their catechol analogues, the enantiomers of 3-(3,4-dihydroxyphenyl)-N-n-propylpiperidine. These isomers... | [
{
"id": "entity-46-0",
"type": "IUPAC",
"text": [
"3-(3-hydroxyphenyl)-N-n-propylpiperidine"
],
"offsets": [
[
87,
127
]
],
"normalized": []
},
{
"id": "entity-46-1",
"type": "ABBREVIATION",
"text": [
"3-PPP"
],
"offsets": [... | [] | [] | [] |
example-47 | 1512594 | [
{
"id": "passage-47",
"type": "abstract",
"text": [
"1512594 Genetic absence epilepsy in rats from Strasbourg--a review. We have selected a strain of rats and designated it the Genetic Absence Epilepsy Rat from Strasbourg (GAERS). In this strain, of the animals present recurrent generalized... | [
{
"id": "entity-47-0",
"type": "TRIVIAL",
"text": [
"ethosuccimide"
],
"offsets": [
[
694,
707
]
],
"normalized": []
},
{
"id": "entity-47-1",
"type": "TRIVIAL",
"text": [
"trimethadione"
],
"offsets": [
[
709,... | [] | [] | [] |
example-48 | 11879044 | [
{
"id": "passage-48",
"type": "abstract",
"text": [
" Diphenol activation of the monophenolase and diphenolase activities of field bean (Dolichos lablab) polyphenol oxidase. This paper reports a study on the hydroxylation of ferulic acid and tyrosine by field bean (Dolichos lablab) polyp... | [
{
"id": "entity-48-0",
"type": "FAMILY",
"text": [
"Diphenol"
],
"offsets": [
[
10,
18
]
],
"normalized": []
},
{
"id": "entity-48-1",
"type": "IUPAC",
"text": [
"ferulic acid"
],
"offsets": [
[
182,
19... | [] | [] | [] |
example-49 | 8960550 | [
{
"id": "passage-49",
"type": "abstract",
"text": [
"In the present investigation, the last two possible modes of generating conformationally semirigid diacylglycerol (DAG) analogues embedded into five-membered ring lactones as templates III and IV are investigated. The first two templates studied... | [
{
"id": "entity-49-0",
"type": "TRIVIAL",
"text": [
"diacylglycerol"
],
"offsets": [
[
99,
113
]
],
"normalized": []
},
{
"id": "entity-49-1",
"type": "ABBREVIATION",
"text": [
"DAG"
],
"offsets": [
[
115,
... | [] | [] | [] |
End of preview. Expand in Data Studio
Dataset Card for SCAI Chemical
SCAI Chemical is a corpus of MEDLINE abstracts that has been annotated to give an overview of the different chemical name classes found in MEDLINE text.
Citation Information
@inproceedings{kolarik:lrec-ws08,
author = {Kol{'a}{ r}ik, Corinna and Klinger, Roman and Friedrich, Christoph M and Hofmann-Apitius, Martin and Fluck, Juliane},
title = {Chemical Names: {T}erminological Resources and Corpora Annotation},
booktitle = {LREC Workshop on Building and Evaluating Resources for Biomedical Text Mining},
year = {2008},
}
- Downloads last month
- 143