id stringlengths 9 11 | document_id stringlengths 8 8 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
example-0 | 18653395 | [
{
"id": "passage-0",
"type": "abstract",
"text": [
"Methotrexate and leucovorin double-modulated 5-fluorouracil combined with cisplatin (MPFL) in metastatic/recurrent head and neck cancer. BACKGROUND: To determine the efficacy and safety profile of the combination of cisplatin and 5-fluorouracil ... | [
{
"id": "entity-0-0",
"type": "DISEASE",
"text": [
"metastatic/recurrent head and neck cancer"
],
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94,
135
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],
"normalized": []
},
{
"id": "entity-0-1",
"type": "DISEASE",
"text": [
"metastatic/recurrent squamous cell... | [] | [] | [] |
example-1 | 18556142 | [
{
"id": "passage-1",
"type": "abstract",
"text": [
"Dose escalation of gemcitabine is possible with concurrent chest three-dimensional rather than two-dimensional radiotherapy: a phase I trial in patients with stage III non-small-cell lung cancer. PURPOSE: To determine in a Phase I study the maxi... | [
{
"id": "entity-1-0",
"type": "DISEASE",
"text": [
"non-small-cell lung cancer"
],
"offsets": [
[
168,
194
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"normalized": []
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{
"id": "entity-1-1",
"type": "DISEASE",
"text": [
"non-small-cell lung cancer"
],
"offsets"... | [] | [] | [] |
example-2 | 18600584 | [
{
"id": "passage-2",
"type": "abstract",
"text": [
"Morphine-6-glucuronide, an active morphine metabolite for the potential treatment of post-operative pain. Morphine-6-glucuronide (M6G) is an active metabolite of morphine that is being developed by CeNeS Pharmaceuticals as an alternative to morp... | [
{
"id": "entity-2-0",
"type": "DISEASE",
"text": [
"post-operative pain"
],
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85,
104
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],
"normalized": []
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{
"id": "entity-2-1",
"type": "DISEASE",
"text": [
"postoperative pain"
],
"offsets": [
[
... | [] | [] | [] |
example-3 | 18773883 | [
{
"id": "passage-3",
"type": "abstract",
"text": [
"La3+ binds to BiP/GRP78 and induces unfolded protein response in HepG2 cells. The effects of La3+ on the unfolded protein response signaling pathways were investigated in human hepatoblastoma HepG2 cells. Our data showed that La3+ could induce u... | [] | [] | [] | [] |
example-4 | 18778717 | [
{
"id": "passage-4",
"type": "abstract",
"text": [
"The effects of 1,4-benzoquinone on c-Myb and topoisomerase II in K-562 cells. Exposure to benzene, a ubiquitous environmental pollutant, has been linked to leukemia, although the mechanism of benzene-initiated leukemogenesis remains unclear. Ben... | [
{
"id": "entity-4-0",
"type": "ADVERSE",
"text": [
"leukemia"
],
"offsets": [
[
157,
165
]
],
"normalized": []
}
] | [] | [] | [] |
example-5 | 18640217 | [
{
"id": "passage-5",
"type": "abstract",
"text": [
"Fragrance material review on alpha-bisabolol. A toxicologic and dermatologic review of alpha-bisabolol when used as a fragrance ingredient is presented."
],
"offsets": [
[
0,
153
]
]
}
] | [] | [] | [] | [] |
example-6 | 18704008 | [
{
"id": "passage-6",
"type": "abstract",
"text": [
"Experimental models of sepsis and their clinical relevance. Sepsis remains a major cause of morbidity and mortality mainly because of sepsis-induced multiple organ dysfunction. In contrast to preclinical studies, most clinical trials of promisin... | [
{
"id": "entity-6-0",
"type": "DISEASE",
"text": [
"sepsis"
],
"offsets": [
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23,
29
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"normalized": []
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{
"id": "entity-6-1",
"type": "DISEASE",
"text": [
"Sepsis"
],
"offsets": [
[
61,
67
]... | [] | [] | [] |
example-7 | 18606837 | [
{
"id": "passage-7",
"type": "abstract",
"text": [
"Efficient clearance of Aspergillus fumigatus in murine lungs by an ultrashort antimicrobial lipopeptide, palmitoyl-lys-ala-DAla-lys. Aspergillus fumigatus is an opportunistic fungal pathogen responsible for invasive aspergillosis in immunocompro... | [
{
"id": "entity-7-0",
"type": "DISEASE",
"text": [
"aspergillosis"
],
"offsets": [
[
217,
230
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"normalized": []
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{
"id": "entity-7-1",
"type": "DISEASE",
"text": [
"aspergillosis"
],
"offsets": [
[
351,
... | [] | [] | [] |
example-8 | 18711350 | [
{
"id": "passage-8",
"type": "abstract",
"text": [
"Allogeneic SCT in refractory or relapsed adult ALL is effective without prior reinduction chemotherapy. We present 60 patients with refractory (n=8) or relapsed (n=52) adult ALL who received allogeneic hematopoietic SCT (HSCT) with (n=41) or wit... | [
{
"id": "entity-8-0",
"type": "DISEASE",
"text": [
"relapsed adult ALL"
],
"offsets": [
[
32,
50
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],
"normalized": []
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{
"id": "entity-8-1",
"type": "DISEASE",
"text": [
"ALL"
],
"offsets": [
[
175,
... | [] | [] | [] |
example-9 | 18590766 | [
{
"id": "passage-9",
"type": "abstract",
"text": [
"Perception of validity of clinical and preclinical methods for assessment of torsades de pointes liability. In 2007 a meeting on drug-induced torsades de pointes (TdP) was held in London, UK, under the auspices of the British Society for Cardiov... | [
{
"id": "entity-9-0",
"type": "DISEASE",
"text": [
"torsades de pointes"
],
"offsets": [
[
77,
96
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],
"normalized": []
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{
"id": "entity-9-1",
"type": "ADVERSE",
"text": [
"torsades de pointes"
],
"offsets": [
[
... | [] | [] | [] |
example-10 | 18942662 | [
{
"id": "passage-10",
"type": "abstract",
"text": [
"Patient willingness to undergo chemotherapy and thoracic radiotherapy for locally advanced non-small cell lung cancer. OBJECTIVES: To determine how Japanese patients with lung cancer weigh the chance of cure and potential survival against the p... | [
{
"id": "entity-10-0",
"type": "DISEASE",
"text": [
"non-small cell lung cancer"
],
"offsets": [
[
91,
117
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],
"normalized": []
},
{
"id": "entity-10-1",
"type": "DISEASE",
"text": [
"lung cancer"
],
"offsets": [
[
... | [] | [] | [] |
example-11 | 18698850 | [
{
"id": "passage-11",
"type": "abstract",
"text": [
"Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: cellular iron chelation mediating cytotoxic activity. Thiosemicarbazones derived from acetylpyrazines were prepared by condensing an acetylpyrazine... | [
{
"id": "entity-11-0",
"type": "ADVERSE",
"text": [
"cytotoxic activity"
],
"offsets": [
[
131,
149
]
],
"normalized": []
},
{
"id": "entity-11-1",
"type": "ADVERSE",
"text": [
"cytotoxic effects"
],
"offsets": [
[
... | [] | [] | [] |
example-12 | 18560533 | [
{
"id": "passage-12",
"type": "abstract",
"text": [
"Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: oncogenic and immunomodulations involving the action of tumor necrosis factor. BACKGROUND: Cadmium is implicated in prostate carcinogenesis, but its oncogen... | [
{
"id": "entity-12-0",
"type": "ADVERSE",
"text": [
"prostate carcinogenesis"
],
"offsets": [
[
205,
228
]
],
"normalized": []
}
] | [] | [] | [] |
example-13 | 18826176 | [
{
"id": "passage-13",
"type": "abstract",
"text": [
"Methylated bismuth, but not bismuth citrate or bismuth glutathione, induces cyto- and genotoxic effects in human cells in vitro. Bismuth compounds are widely used in industrial processes and products. In medicine, bismuth salts have been applie... | [
{
"id": "entity-13-0",
"type": "ADVERSE",
"text": [
"genotoxic effects"
],
"offsets": [
[
86,
103
]
],
"normalized": []
},
{
"id": "entity-13-1",
"type": "DISEASE",
"text": [
"Helicobacter pylori infections"
],
"offsets": [
... | [] | [] | [] |
example-14 | 18636394 | [
{
"id": "passage-14",
"type": "abstract",
"text": [
"Integrated disinfection by-products research: assessing reproductive and developmental risks posed by complex disinfection by-product mixtures. This article presents a toxicologically-based risk assessment strategy for identifying the individua... | [
{
"id": "entity-14-0",
"type": "ADVERSE",
"text": [
"Developmental toxicity"
],
"offsets": [
[
480,
502
]
],
"normalized": []
}
] | [] | [] | [] |
example-15 | 18596603 | [
{
"id": "passage-15",
"type": "abstract",
"text": [
"Chemoprevention in postmenopausal women. Several large, prospective trials have evaluated tamoxifen compared with placebo for breast cancer risk reduction in women at increased risk of breast cancer. Combined results from these trials demonstra... | [
{
"id": "entity-15-0",
"type": "DISEASE",
"text": [
"breast cancer"
],
"offsets": [
[
127,
140
]
],
"normalized": []
},
{
"id": "entity-15-1",
"type": "DISEASE",
"text": [
"breast cancer"
],
"offsets": [
[
186,... | [] | [] | [] |
example-16 | 18664513 | [
{
"id": "passage-16",
"type": "abstract",
"text": [
"DNA damage and repair detected by the comet assay in lymphocytes of african petrol attendants: a pilot study. Petrol attendants are exposed to petrol volatile organic compounds (VOCs) which may have genotoxic and carcinogenic effects. The singl... | [
{
"id": "entity-16-0",
"type": "ADVERSE",
"text": [
"carcinogenic effects"
],
"offsets": [
[
214,
234
]
],
"normalized": []
}
] | [] | [] | [] |
example-17 | 18569277 | [
{
"id": "passage-17",
"type": "abstract",
"text": [
"Menorrhagia and severe menstrual pain related to the use of adalimumab in a psoriatic. The case is reported of a 32-year-old morbidly obese white woman who used adalimumab 40 mg every other week for 4 months for psoriatic arthritis, psoriasis v... | [
{
"id": "entity-17-0",
"type": "ADVERSE",
"text": [
"Menorrhagia"
],
"offsets": [
[
0,
11
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],
"normalized": []
},
{
"id": "entity-17-1",
"type": "ADVERSE",
"text": [
"menstrual pain"
],
"offsets": [
[
23,
... | [] | [] | [] |
example-18 | 18636785 | [
{
"id": "passage-18",
"type": "abstract",
"text": [
"Effects of stratification on data mining in the US Vaccine Adverse Event Reporting System (VAERS). BACKGROUND: Vaccines are administered differentially according to age and sex, and disease patterns also vary among people of different age and s... | [] | [] | [] | [] |
example-19 | 18803960 | [
{
"id": "passage-19",
"type": "abstract",
"text": [
"Brain development: anatomy, connectivity, adaptive plasticity, and toxicity. The developing brain is inherently more vulnerable to injury than the adult brain because brain development is extraordinarily complex, with periods of unique suscepti... | [
{
"id": "entity-19-0",
"type": "ADVERSE",
"text": [
"neurodevelopmental disorders"
],
"offsets": [
[
812,
840
]
],
"normalized": []
},
{
"id": "entity-19-1",
"type": "ADVERSE",
"text": [
"subclinical brain dysfunction"
],
"o... | [] | [] | [] |
example-20 | 18642029 | [
{
"id": "passage-20",
"type": "abstract",
"text": [
"Impact of different anticancer regimens on biomarkers of angiogenesis in patients with advanced hepatocellular cancer. OBJECTIVE: Advanced hepatocellular cancer (HCC) is a highly vascularised tumor with limited treatment options. We wanted to e... | [
{
"id": "entity-20-0",
"type": "DISEASE",
"text": [
"hepatocellular cancer"
],
"offsets": [
[
96,
117
]
],
"normalized": []
},
{
"id": "entity-20-1",
"type": "DISEASE",
"text": [
"hepatocellular cancer"
],
"offsets": [
... | [] | [] | [] |
example-21 | 18835419 | [
{
"id": "passage-21",
"type": "abstract",
"text": [
"In vitro investigation of oxide nanoparticle and carbon nanotube toxicity and intracellular accumulation in A549 human pneumocytes. If released in the environment, nanomaterials might be inhaled by populations and cause damage to the deepest re... | [
{
"id": "entity-21-0",
"type": "ADVERSE",
"text": [
"nanotubes toxicity"
],
"offsets": [
[
1177,
1195
]
],
"normalized": []
},
{
"id": "entity-21-1",
"type": "ADVERSE",
"text": [
"cytotoxicity"
],
"offsets": [
[
... | [] | [] | [] |
example-22 | 18544904 | [
{
"id": "passage-22",
"type": "abstract",
"text": [
"Points to consider on the non-clinical safety evaluation of anticancer drugs. Since malignant tumors are life-threatening, the death rate from these diseases is high, and existing therapies have limited effectiveness, it is desired to provide n... | [
{
"id": "entity-22-0",
"type": "DISEASE",
"text": [
"malignant tumors"
],
"offsets": [
[
85,
101
]
],
"normalized": []
}
] | [] | [] | [] |
example-23 | 18812021 | [
{
"id": "passage-23",
"type": "abstract",
"text": [
"Delivery of daunorubicin to cancer cells with decreased toxicity by association with a lipidic nanoemulsion that binds to LDL receptors. A lipidic nanoemulsion termed LDE concentrates in neoplastic cells after injection into the bloodstream and... | [
{
"id": "entity-23-0",
"type": "ADVERSE",
"text": [
"cytotoxicity"
],
"offsets": [
[
534,
546
]
],
"normalized": []
},
{
"id": "entity-23-1",
"type": "ADVERSE",
"text": [
"animal toxicity"
],
"offsets": [
[
551... | [] | [] | [] |
example-24 | 18751929 | [
{
"id": "passage-24",
"type": "abstract",
"text": [
"The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats. The current therapeutic advance in which future drugs are designed to possess varied pharmacological... | [
{
"id": "entity-24-0",
"type": "DISEASE",
"text": [
"Alzheimer's disease"
],
"offsets": [
[
602,
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]
],
"normalized": []
},
{
"id": "entity-24-1",
"type": "DISEASE",
"text": [
"AD"
],
"offsets": [
[
623,
... | [] | [] | [] |
example-25 | 18555464 | [
{
"id": "passage-25",
"type": "abstract",
"text": [
"High dose chemotherapy and autologous stem cell transplantation in patients with multiple myeloma: the experience of a single haematological unit. PURPOSE: To study the toxicity of high dose chemotherapy (HDCT) in multiple myeloma (MM) patients... | [
{
"id": "entity-25-0",
"type": "DISEASE",
"text": [
"multiple myeloma"
],
"offsets": [
[
81,
97
]
],
"normalized": []
},
{
"id": "entity-25-1",
"type": "DISEASE",
"text": [
"multiple myeloma"
],
"offsets": [
[
... | [] | [] | [] |
example-26 | 18612759 | [
{
"id": "passage-26",
"type": "abstract",
"text": [
"Clinical and radiological features of brain neurotoxicity caused by antitumor and immunosuppressant treatments. Antitumor and immunosuppressant treatment-related neurotoxicity can determine nonspecific clinical syndromes. Exclusion of other pos... | [
{
"id": "entity-26-0",
"type": "ADVERSE",
"text": [
"brain neurotoxicity"
],
"offsets": [
[
38,
57
]
],
"normalized": []
},
{
"id": "entity-26-1",
"type": "ADVERSE",
"text": [
"neurotoxicity"
],
"offsets": [
[
... | [] | [] | [] |
example-27 | 18690972 | [
{
"id": "passage-27",
"type": "abstract",
"text": [
"Drotrecogin alfa (activated) in the treatment of severe sepsis. Severe sepsis and septic shock are common in the critically ill patient and account for considerable morbidity and mortality not to mention the high associated costs. Advances in o... | [
{
"id": "entity-27-0",
"type": "DISEASE",
"text": [
"sepsis"
],
"offsets": [
[
56,
62
]
],
"normalized": []
},
{
"id": "entity-27-1",
"type": "DISEASE",
"text": [
"sepsis"
],
"offsets": [
[
72,
78
... | [] | [] | [] |
example-28 | 18614266 | [
{
"id": "passage-28",
"type": "abstract",
"text": [
"Current regulatory toxicology perspectives on the development of herbal medicines to prescription drug products in the United States. Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug ... | [
{
"id": "entity-28-0",
"type": "DISEASE",
"text": [
"perianal warts"
],
"offsets": [
[
546,
560
]
],
"normalized": []
},
{
"id": "entity-28-1",
"type": "ADVERSE",
"text": [
"acute toxicity"
],
"offsets": [
[
10... | [] | [] | [] |
example-29 | 18840496 | [
{
"id": "passage-29",
"type": "abstract",
"text": [
"Genotoxicity of topoisomerase II inhibitors: an anti-infective perspective. At present, an inevitable consequence of a chemical's inhibitory activity on key regulators of DNA topology in bacteria, the type II topoisomerases, is a less pronounce... | [
{
"id": "entity-29-0",
"type": "ADVERSE",
"text": [
"genotoxicity"
],
"offsets": [
[
806,
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]
],
"normalized": []
},
{
"id": "entity-29-1",
"type": "ADVERSE",
"text": [
"genotoxicity"
],
"offsets": [
[
979,
... | [] | [] | [] |
example-30 | 18790714 | [
{
"id": "passage-30",
"type": "abstract",
"text": [
"Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Saffron (dried stigmas of Crocus sativus L.) has been used as a spice, food colorant and medicinal plant for millennia. In this study cytotoxic effect ... | [
{
"id": "entity-30-0",
"type": "ADVERSE",
"text": [
"cytotoxic effect"
],
"offsets": [
[
228,
244
]
],
"normalized": []
},
{
"id": "entity-30-1",
"type": "ADVERSE",
"text": [
"saffron toxicity"
],
"offsets": [
[
... | [] | [] | [] |
example-31 | 18951238 | [
{
"id": "passage-31",
"type": "abstract",
"text": [
"Synthesis of some pyrazolyl benzenesulfonamide derivatives as dual anti-inflammatory antimicrobial agents. Four series of pyrazolylbenzenesulfonamide derivatives were synthesized and evaluated for their anti-inflammatory activity using cotton p... | [
{
"id": "entity-31-0",
"type": "ADVERSE",
"text": [
"granuloma"
],
"offsets": [
[
259,
268
]
],
"normalized": []
},
{
"id": "entity-31-1",
"type": "ADVERSE",
"text": [
"edema"
],
"offsets": [
[
301,
306... | [] | [] | [] |
example-32 | 18690095 | [
{
"id": "passage-32",
"type": "abstract",
"text": [
"Multicenter phase II study of capecitabine plus oxaliplatin as a first-line therapy in Chinese patients with advanced gastric cancer. The efficacy of chemotherapy for advanced gastric cancer with palliative intent compared with supportive care ... | [
{
"id": "entity-32-0",
"type": "DISEASE",
"text": [
"gastric cancer"
],
"offsets": [
[
118,
132
]
],
"normalized": []
},
{
"id": "entity-32-1",
"type": "DISEASE",
"text": [
"gastric cancer"
],
"offsets": [
[
17... | [] | [] | [] |
example-33 | 18854394 | [
{
"id": "passage-33",
"type": "abstract",
"text": [
"Lack of therapeutic effect of the histone deacetylase inhibitor vorinostat in patients with metastatic radioiodine-refractory thyroid carcinoma. CONTEXT: Aberrant histone deacetylase activity is seen in a variety of malignancies, and histone de... | [
{
"id": "entity-33-0",
"type": "DISEASE",
"text": [
"metastatic radioiodine-refractory thyroid carcinoma"
],
"offsets": [
[
92,
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]
],
"normalized": []
},
{
"id": "entity-33-1",
"type": "DISEASE",
"text": [
"thyroid cancer"
],... | [] | [] | [] |
example-34 | 18585919 | [
{
"id": "passage-34",
"type": "abstract",
"text": [
"Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity. G1-phase cyclin D1 (cD1) expression has been documented in post-mitotic neurons undergoing apoptosis, leading others to propose that attempted cell cycle... | [
{
"id": "entity-34-0",
"type": "ADVERSE",
"text": [
"neurotoxicity"
],
"offsets": [
[
76,
89
]
],
"normalized": []
},
{
"id": "entity-34-1",
"type": "ADVERSE",
"text": [
"Seizure"
],
"offsets": [
[
504,
... | [] | [] | [] |
example-35 | 18627268 | [
{
"id": "passage-35",
"type": "abstract",
"text": [
"Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. Highly active antiretroviral treatment has resulted in dramatically increased life expectancy among patients with HIV infection wh... | [
{
"id": "entity-35-0",
"type": "DISEASE",
"text": [
"infectious diseases"
],
"offsets": [
[
10,
29
]
],
"normalized": []
},
{
"id": "entity-35-1",
"type": "DISEASE",
"text": [
"HIV infection"
],
"offsets": [
[
... | [] | [] | [] |
example-36 | 18693154 | [
{
"id": "passage-36",
"type": "abstract",
"text": [
"Adapalene 0.1% and benzoyl peroxide 2.5% as a fixed-dose combination gel is as well tolerated as the individual components alone in terms of cumulative irritancy. International guidelines recommend the combination of retinoids (e.g. adapalene, ... | [
{
"id": "entity-36-0",
"type": "DISEASE",
"text": [
"acne"
],
"offsets": [
[
291,
295
]
],
"normalized": []
},
{
"id": "entity-36-1",
"type": "DISEASE",
"text": [
"acne"
],
"offsets": [
[
465,
469
... | [] | [] | [] |
example-37 | 18602129 | [
{
"id": "passage-37",
"type": "abstract",
"text": [
"Gene expression profiles in the cerebellum and hippocampus following exposure to a neurotoxicant, Aroclor 1254: developmental effects. The developmental consequences of exposure to the polychlorinated biphenyls (PCBs) have been widely studied, ... | [] | [] | [] | [] |
example-38 | 18666210 | [
{
"id": "passage-38",
"type": "abstract",
"text": [
"Cognitive effects of hormone therapy in men with prostate cancer: a review. BACKGROUND: Men who receive androgen-deprivation therapy (ADT) for prostate cancer experience several side effects from this treatment. A few recent studies have examin... | [
{
"id": "entity-38-0",
"type": "DISEASE",
"text": [
"prostate cancer"
],
"offsets": [
[
49,
64
]
],
"normalized": []
},
{
"id": "entity-38-1",
"type": "DISEASE",
"text": [
"prostate cancer"
],
"offsets": [
[
14... | [] | [] | [] |
example-39 | 18751444 | [
{
"id": "passage-39",
"type": "abstract",
"text": [
"Paclitaxel and pegylated liposomal doxorubicin in recurrent head and neck cancer: clinical and unexpected pharmacokinetic interactions. BACKGROUND: The combination of paclitaxel (PTX) with pegylated liposomal doxorubicin (PLD) is an interesting... | [
{
"id": "entity-39-0",
"type": "DISEASE",
"text": [
"recurrent head and neck cancer"
],
"offsets": [
[
50,
80
]
],
"normalized": []
},
{
"id": "entity-39-1",
"type": "DISEASE",
"text": [
"recurrent head and neck cancer"
],
"... | [] | [] | [] |
example-40 | 18607570 | [
{
"id": "passage-40",
"type": "abstract",
"text": [
"Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells. Denbinobin is a phenanthraquinone derivative present in the stems of Ephemerantha lonchophylla. We showed that denbinob... | [] | [] | [] | [] |
example-41 | 18542079 | [
{
"id": "passage-41",
"type": "abstract",
"text": [
"Effect of treatment with epoetin-beta on survival, tumour progression and thromboembolic events in patients with cancer: an updated meta-analysis of 12 randomised controlled studies including 2301 patients. Epoetin-beta is used to treat patient... | [
{
"id": "entity-41-0",
"type": "DISEASE",
"text": [
"tumour progression"
],
"offsets": [
[
51,
69
]
],
"normalized": []
},
{
"id": "entity-41-1",
"type": "DISEASE",
"text": [
"thromboembolic events"
],
"offsets": [
[
... | [] | [] | [] |
example-42 | 18614347 | [
{
"id": "passage-42",
"type": "abstract",
"text": [
"Effect of fluticasone propionate/salmeterol (250/50 microg) or salmeterol (50 microg) on COPD exacerbations. OBJECTIVES: COPD exacerbations are associated with significant morbidity and mortality. This randomized, double-blind, parallel-group, ... | [
{
"id": "entity-42-0",
"type": "DISEASE",
"text": [
"COPD exacerbations"
],
"offsets": [
[
89,
107
]
],
"normalized": []
},
{
"id": "entity-42-1",
"type": "DISEASE",
"text": [
"COPD exacerbations"
],
"offsets": [
[
... | [] | [] | [] |
example-43 | 18759760 | [
{
"id": "passage-43",
"type": "abstract",
"text": [
"Efficacy of fractionated gemtuzumab ozogamicin combined with cytarabine in advanced childhood myeloid leukaemia. Gemtuzumab ozogamicin (GO) monotherapy is reported to yield a 20-30% response rate in advanced acute myeloid leukaemia (AML). This ... | [
{
"id": "entity-43-0",
"type": "DISEASE",
"text": [
"myeloid leukaemia"
],
"offsets": [
[
94,
111
]
],
"normalized": []
},
{
"id": "entity-43-1",
"type": "DISEASE",
"text": [
"acute myeloid leukaemia"
],
"offsets": [
[... | [] | [] | [] |
example-44 | 18622679 | [
{
"id": "passage-44",
"type": "abstract",
"text": [
"Effect of linezolid against postneurosurgical meningitis caused by methicillin-resistant Staphylococcus epidermidis: case report. A 67-year-old man who had twice previously undergone operations for a tuberculum sellae meningioma was admitted to... | [
{
"id": "entity-44-0",
"type": "ADVERSE",
"text": [
"postneurosurgical meningitis"
],
"offsets": [
[
28,
56
]
],
"normalized": []
},
{
"id": "entity-44-1",
"type": "DISEASE",
"text": [
"tuberculum sellae meningioma"
],
"offs... | [] | [] | [] |
example-45 | 18628507 | [
{
"id": "passage-45",
"type": "abstract",
"text": [
"Angio-oedema as an unusual tolerable side effect of voriconazole therapy. Voriconazole (VRC) has not previously been reported to cause angio-oedema. Here, we report a case of angio-oedema associated with VRC therapy. A 37-year-old woman with re... | [
{
"id": "entity-45-0",
"type": "DISEASE",
"text": [
"Angio-oedema"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "entity-45-1",
"type": "DISEASE",
"text": [
"angio-oedema"
],
"offsets": [
[
136,
... | [] | [] | [] |
example-46 | 18657019 | [
{
"id": "passage-46",
"type": "abstract",
"text": [
"Extended- and continuous-cycle oral contraceptives. Five new oral contraceptives, classified as extended- or continuous-cycle oral contraceptives, have been approved by the United States Food and Drug Administration. These agents have various c... | [
{
"id": "entity-46-0",
"type": "ADVERSE",
"text": [
"change in bleeding pattern"
],
"offsets": [
[
1406,
1432
]
],
"normalized": []
},
{
"id": "entity-46-1",
"type": "ADVERSE",
"text": [
"breakthrough bleeding"
],
"offsets":... | [] | [] | [] |
example-47 | 18828020 | [
{
"id": "passage-47",
"type": "abstract",
"text": [
"Phase II trial of S-1 and concurrent radiotherapy in patients with locally advanced pancreatic cancer. PURPOSE: S-1 has a favorable effect in unresectable pancreatic cancer and a potential radiosensitizer. In addition, daily oral administration... | [
{
"id": "entity-47-0",
"type": "DISEASE",
"text": [
"pancreatic cancer"
],
"offsets": [
[
84,
101
]
],
"normalized": []
},
{
"id": "entity-47-1",
"type": "DISEASE",
"text": [
"pancreatic cancer"
],
"offsets": [
[
... | [] | [] | [] |
example-48 | 18938110 | [
{
"id": "passage-48",
"type": "abstract",
"text": [
"Induction of mucosal tolerance in SLE: a sniff or a sip away from ameliorating lupus? Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by aberrant immune responses against intracellularly derived self antigens. Treatmen... | [
{
"id": "entity-48-0",
"type": "DISEASE",
"text": [
"SLE"
],
"offsets": [
[
34,
37
]
],
"normalized": []
},
{
"id": "entity-48-1",
"type": "DISEASE",
"text": [
"Systemic lupus erythematosus"
],
"offsets": [
[
8... | [] | [] | [] |
example-49 | 18759348 | [
{
"id": "passage-49",
"type": "abstract",
"text": [
"Biochemical mechanism of acetaminophen (APAP) induced toxicity in melanoma cell lines. In this work, we investigated the biochemical mechanism of acetaminophen (APAP) induced toxicity in SK-MEL-28 melanoma cells using tyrosinase enzyme as a mol... | [
{
"id": "entity-49-0",
"type": "DISEASE",
"text": [
"cancer"
],
"offsets": [
[
252,
258
]
],
"normalized": []
},
{
"id": "entity-49-1",
"type": "ADVERSE",
"text": [
"melanoma cell toxicity"
],
"offsets": [
[
91... | [] | [] | [] |
example-50 | 18952618 | [
{
"id": "passage-50",
"type": "abstract",
"text": [
"Hepatic safety of tipranavir plus ritonavir (TPV/r)-based antiretroviral combinations: effect of hepatitis virus co-infection and pre-existing fibrosis. OBJECTIVES: The aim of this study was to evaluate the incidence and risk factors of severe ... | [
{
"id": "entity-50-0",
"type": "DISEASE",
"text": [
"hepatitis virus co-infection"
],
"offsets": [
[
97,
125
]
],
"normalized": []
},
{
"id": "entity-50-1",
"type": "DISEASE",
"text": [
"fibrosis"
],
"offsets": [
[
... | [] | [] | [] |
example-51 | 18721818 | [
{
"id": "passage-51",
"type": "abstract",
"text": [
"18beta-Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti-cancer drug toxicity. Defects in mitochondrial function have been shown to participate in the induction of cell deat... | [
{
"id": "entity-51-0",
"type": "ADVERSE",
"text": [
"drug toxicity"
],
"offsets": [
[
135,
148
]
],
"normalized": []
},
{
"id": "entity-51-1",
"type": "ADVERSE",
"text": [
"synergistic toxic effect"
],
"offsets": [
[
... | [] | [] | [] |
example-52 | 18759504 | [
{
"id": "passage-52",
"type": "abstract",
"text": [
"Role of the nitro functionality in the DNA binding of 3-nitro-10-methylbenzothiazolo[3,2-a]quinolinium chloride. Interest in DNA binding drugs has increased in recent years due to their importance in the treatment of genome-related diseases, li... | [
{
"id": "entity-52-0",
"type": "DISEASE",
"text": [
"genome-related diseases"
],
"offsets": [
[
218,
241
]
],
"normalized": []
},
{
"id": "entity-52-1",
"type": "DISEASE",
"text": [
"cancer"
],
"offsets": [
[
2... | [] | [] | [] |
example-53 | 18641546 | [
{
"id": "passage-53",
"type": "abstract",
"text": [
"AcylMPAG plasma concentrations and mycophenolic acid-related side effects in patients undergoing renal transplantation are not related to the UGT2B7-840G>A gene polymorphism. Mycophenolic acid (MPA) is metabolized primarily by glucuronidation t... | [
{
"id": "entity-53-0",
"type": "ADVERSE",
"text": [
"mycophenolic acid-related side effects"
],
"offsets": [
[
35,
73
]
],
"normalized": []
},
{
"id": "entity-53-1",
"type": "ADVERSE",
"text": [
"diarrhea"
],
"offsets": [
... | [] | [] | [] |
example-54 | 18704471 | [
{
"id": "passage-54",
"type": "abstract",
"text": [
"Relationship between airborne pollen count and treatment outcome in Japanese cedar pollinosis patients. In Japan, information on daily Japanese cedar pollen counts is made public during pollen season. If symptom severity and treatment outcome a... | [
{
"id": "entity-54-0",
"type": "DISEASE",
"text": [
"pollinosis"
],
"offsets": [
[
83,
93
]
],
"normalized": []
},
{
"id": "entity-54-1",
"type": "DISEASE",
"text": [
"seasonal allergic rhinitis"
],
"offsets": [
[
... | [] | [] | [] |
example-55 | 18690337 | [
{
"id": "passage-55",
"type": "abstract",
"text": [
"Clinical implications of clopidogrel resistance. The benefits of clopidogrel in the treatment and prevention of coronary artery disease are well established, however, not all individuals respond in the same way to clopidogrel; there are patient... | [
{
"id": "entity-55-0",
"type": "DISEASE",
"text": [
"coronary artery disease"
],
"offsets": [
[
113,
136
]
],
"normalized": []
},
{
"id": "entity-55-1",
"type": "ADVERSE",
"text": [
"adverse cardiovascular events"
],
"offset... | [] | [] | [] |
example-56 | 18844846 | [
{
"id": "passage-56",
"type": "abstract",
"text": [
"Vitamin D: criteria for safety and efficacy. The functional status indicator for vitamin D, for both safety and efficacy, is serum 25-hydroxyvitamin D concentration. Efficacy for several health endpoints requires levels of 80 nmol/L or higher. ... | [] | [] | [] | [] |
example-57 | 18774727 | [
{
"id": "passage-57",
"type": "abstract",
"text": [
"Synergistic cytotoxic effect of different sized ZnO nanoparticles and daunorubicin against leukemia cancer cells under UV irradiation. Failure of chemotherapy to the malignant tumor is usually induced by multidrug resistance (MDR). The developm... | [
{
"id": "entity-57-0",
"type": "ADVERSE",
"text": [
"cytotoxic effect"
],
"offsets": [
[
12,
28
]
],
"normalized": []
},
{
"id": "entity-57-1",
"type": "DISEASE",
"text": [
"malignant tumor"
],
"offsets": [
[
1... | [] | [] | [] |
example-58 | 18560212 | [
{
"id": "passage-58",
"type": "abstract",
"text": [
"Partial peroxisome proliferator-activated receptor agonist angiotensin receptor blockers. Potential multipronged strategy in stroke prevention. BACKGROUND AND PURPOSE: Although their primary mechanism of action is blood pressure lowering, emerg... | [
{
"id": "entity-58-0",
"type": "DISEASE",
"text": [
"stroke"
],
"offsets": [
[
125,
131
]
],
"normalized": []
},
{
"id": "entity-58-1",
"type": "DISEASE",
"text": [
"insulin resistance"
],
"offsets": [
[
426,
... | [] | [] | [] |
example-59 | 18821393 | [
{
"id": "passage-59",
"type": "abstract",
"text": [
"Nonclinical aspects of biopharmaceutical development: discussion of case studies at a PhRMA-FDA workshop. Robust assessments of the nonclinical safety profile of biopharmaceuticals are best developed on a scientifically justified, case-by-case ... | [
{
"id": "entity-59-0",
"type": "ADVERSE",
"text": [
"reproductive toxicity"
],
"offsets": [
[
1208,
1229
]
],
"normalized": []
}
] | [] | [] | [] |
example-60 | 18755865 | [
{
"id": "passage-60",
"type": "abstract",
"text": [
"Clinical features and therapeutic management of subglottic stenosis in patients with Wegener's granulomatosis. The objective of the study was to evaluate the clinical features, response to treatment, and long-term outcome of subglottic stenosis... | [
{
"id": "entity-60-0",
"type": "DISEASE",
"text": [
"subglottic stenosis"
],
"offsets": [
[
48,
67
]
],
"normalized": []
},
{
"id": "entity-60-1",
"type": "DISEASE",
"text": [
"Wegener's granulomatosis"
],
"offsets": [
... | [] | [] | [] |
example-61 | 18620786 | [
{
"id": "passage-61",
"type": "abstract",
"text": [
"Recent developments in the treatment of aggressive non-Hodgkin lymphoma. SUMMARY: Options for treating aggressive non-Hodgkin lymphoma (NHL) have expanded in recent years. In phase 3 clinical trials, giving rituximab with cyclophosphamide, vinc... | [
{
"id": "entity-61-0",
"type": "DISEASE",
"text": [
"non-Hodgkin lymphoma"
],
"offsets": [
[
51,
71
]
],
"normalized": []
},
{
"id": "entity-61-1",
"type": "DISEASE",
"text": [
"non-Hodgkin lymphoma"
],
"offsets": [
[
... | [] | [] | [] |
example-62 | 18753950 | [
{
"id": "passage-62",
"type": "abstract",
"text": [
"Factors affecting sensitivity of distortion-product otoacoustic emissions to ototoxic hearing loss. OBJECTIVES: (1) To determine the ototoxicity detection rate (sensitivity) for distortion-product otoacoustic emissions (DPOAEs) testing in adult... | [
{
"id": "entity-62-0",
"type": "ADVERSE",
"text": [
"ototoxic hearing loss"
],
"offsets": [
[
77,
98
]
],
"normalized": []
},
{
"id": "entity-62-1",
"type": "ADVERSE",
"text": [
"ototoxicity"
],
"offsets": [
[
... | [] | [] | [] |
example-63 | 18671473 | [
{
"id": "passage-63",
"type": "abstract",
"text": [
"A new lipoglycopeptide: telavancin. The increase in infections caused by resistant Gram-positive organisms has led to an urgent need for new antibiotics. Telavancin is a rapidly bactericidal lipoglycopeptide with multiple mechanisms of action, ... | [
{
"id": "entity-63-0",
"type": "DISEASE",
"text": [
"renal impairment"
],
"offsets": [
[
855,
871
]
],
"normalized": []
},
{
"id": "entity-63-1",
"type": "ADVERSE",
"text": [
"taste disturbance"
],
"offsets": [
[
... | [] | [] | [] |
example-64 | 18581028 | [
{
"id": "passage-64",
"type": "abstract",
"text": [
"Acute generalised exanthematous pustulosis and toxic epidermal necrolysis induced by carbamazepine. Acute generalised exanthematous pustulosis and Stevens-Johnson syndrome (toxic epidermal necrolysis spectrum of severe cutaneous drug reactions)... | [
{
"id": "entity-64-0",
"type": "ADVERSE",
"text": [
"Acute generalised exanthematous pustulosis"
],
"offsets": [
[
0,
42
]
],
"normalized": []
},
{
"id": "entity-64-1",
"type": "ADVERSE",
"text": [
"toxic epidermal necrolysis"
]... | [] | [] | [] |
example-65 | 18549882 | [
{
"id": "passage-65",
"type": "abstract",
"text": [
"Proteasome activation by hepatitis C core protein is reversed by ethanol-induced oxidative stress. BACKGROUND & AIMS: The proteasome is a major cellular proteinase. Its activity is modulated by cellular oxidants. Hepatitis C core protein and et... | [] | [] | [] | [] |
example-66 | 18798698 | [
{
"id": "passage-66",
"type": "abstract",
"text": [
"Evolving concepts in liver tissue modeling and implications for in vitro toxicology. The development of human cell models stably expressing functional properties of the in vivo cells they are derived from for predicting toxicity of chemicals is... | [
{
"id": "entity-66-0",
"type": "ADVERSE",
"text": [
"chronic toxicity"
],
"offsets": [
[
1142,
1158
]
],
"normalized": []
}
] | [] | [] | [] |
example-67 | 18763324 | [
{
"id": "passage-67",
"type": "abstract",
"text": [
"Mycophenolate mofetil-related gastrointestinal mucosal injury: variable injury patterns, including graft-versus-host disease-like changes. Mycophenolate mofetil (MMF) is a commonly used immunosuppressive drug used in the management of transplan... | [
{
"id": "entity-67-0",
"type": "ADVERSE",
"text": [
"gastrointestinal mucosal injury"
],
"offsets": [
[
30,
61
]
],
"normalized": []
},
{
"id": "entity-67-1",
"type": "ADVERSE",
"text": [
"graft-versus-host disease"
],
"offs... | [] | [] | [] |
example-68 | 18775466 | [
{
"id": "passage-68",
"type": "abstract",
"text": [
"Broccoli flower head extract reduces mitomycin-C induced sister chromatid exchange in cultured human lymphocytes. This study is a continuation of our previous work [Murugan, S.S., Balakrishnamurthy, P., Mathew, Y.J., 2007. Antimutagenic effect ... | [] | [] | [] | [] |
example-69 | 18793295 | [
{
"id": "passage-69",
"type": "abstract",
"text": [
"Establishing causality in the assessment of safety of medicines for children. BACKGROUND: Data on safety of medicines in children typically arises from various sources, rendering assessment of causality challenging. METHODS: We outline these so... | [] | [] | [] | [] |
example-70 | 18695700 | [
{
"id": "passage-70",
"type": "abstract",
"text": [
"The effect of thiazolidinediones on BMD and osteoporosis. Thiazolidinediones, also known as glitazones, are insulin-sensitizing medications that account for approximately 21% of oral antihyperglycemic drugs used in the US. Although the main the... | [
{
"id": "entity-70-0",
"type": "DISEASE",
"text": [
"BMD"
],
"offsets": [
[
36,
39
]
],
"normalized": []
},
{
"id": "entity-70-1",
"type": "DISEASE",
"text": [
"osteoporosis"
],
"offsets": [
[
44,
56
... | [] | [] | [] |
example-71 | 18707870 | [
{
"id": "passage-71",
"type": "abstract",
"text": [
"Raltitrexed (Tomudex) versus standard leucovorin-modulated bolus 5-fluorouracil: Results from the randomised phase III Pan-European Trial in Adjuvant Colon Cancer 01 (PETACC-1). OBJECTIVES: PETACC-1 assessed if raltitrexed is non-inferior to 5-... | [
{
"id": "entity-71-0",
"type": "DISEASE",
"text": [
"Colon Cancer"
],
"offsets": [
[
150,
162
]
],
"normalized": []
},
{
"id": "entity-71-1",
"type": "DISEASE",
"text": [
"colon cancer"
],
"offsets": [
[
353,
... | [] | [] | [] |
example-72 | 18636418 | [
{
"id": "passage-72",
"type": "abstract",
"text": [
"Identifying patterns of adverse event reporting for four members of the angiotensin II receptor blockers class of drugs: revisiting the Weber effect. PURPOSE: To evaluate the evidence for temporal reporting patterns, such as the Weber effect, i... | [] | [] | [] | [] |
example-73 | 18597652 | [
{
"id": "passage-73",
"type": "abstract",
"text": [
"Pharmacogenetics of Crohn's disease. The considerable interindividual differences in efficacy and side effects of commonly used medications in Crohn's disease are partly owing to genetic polymorphisms. Many genetic variants have been studied in... | [
{
"id": "entity-73-0",
"type": "DISEASE",
"text": [
"Crohn's disease"
],
"offsets": [
[
20,
35
]
],
"normalized": []
},
{
"id": "entity-73-1",
"type": "DISEASE",
"text": [
"Crohn's disease"
],
"offsets": [
[
14... | [] | [] | [] |
example-74 | 18840369 | [
{
"id": "passage-74",
"type": "abstract",
"text": [
"Pharmacokinetic and safety profile of rupatadine when coadministered with azithromycin at steady-state levels: a randomized, open-label, two-way, crossover, Phase I study. BACKGROUND: Rupatadine is an oral active antihistamine and platelet-acti... | [
{
"id": "entity-74-0",
"type": "DISEASE",
"text": [
"allergic rhinitis"
],
"offsets": [
[
302,
319
]
],
"normalized": []
},
{
"id": "entity-74-1",
"type": "DISEASE",
"text": [
"chronic urticaria"
],
"offsets": [
[
... | [] | [] | [] |
example-75 | 18676805 | [
{
"id": "passage-75",
"type": "abstract",
"text": [
"Pluripotent stem cell lines. The derivation of human embryonic stem cells 10 years ago ignited an explosion of public interest in stem cells, yet this achievement depended on prior decades of research on mouse embryonic carcinoma cells and embr... | [] | [] | [] | [] |
example-76 | 18789051 | [
{
"id": "passage-76",
"type": "abstract",
"text": [
"Advances in plasma skin regeneration. Plasma skin regeneration (PSR) is a novel method of resurfacing that uses plasma energy to create a thermal effect on the skin. PSR is different from lasers, light sources, and ablative lasers in that it is... | [
{
"id": "entity-76-0",
"type": "DISEASE",
"text": [
"wound"
],
"offsets": [
[
407,
412
]
],
"normalized": []
},
{
"id": "entity-76-1",
"type": "DISEASE",
"text": [
"rhytides of the body"
],
"offsets": [
[
722,
... | [] | [] | [] |
example-77 | 18634931 | [
{
"id": "passage-77",
"type": "abstract",
"text": [
"Hydrogen peroxide induces heme oxygenase-1 and dentin sialophosphoprotein mRNA in human pulp cells. Although the induction of heme oxygenase-1 (HO-1) by hydrogen peroxide (H2O2) has been reported, the HO-1 and odontoblastic differentiation-indu... | [] | [] | [] | [] |
example-78 | 18761239 | [
{
"id": "passage-78",
"type": "abstract",
"text": [
"Pharmacokinetics of levobupivacaine 0.5% after superficial or combined (deep and superficial) cervical plexus block in patients undergoing minimally invasive parathyroidectomy. STUDY OBJECTIVE: To evaluate the pharmacokinetic profile of 0.35 mL... | [
{
"id": "entity-78-0",
"type": "ADVERSE",
"text": [
"cardiovascular toxicity"
],
"offsets": [
[
1854,
1877
]
],
"normalized": []
}
] | [] | [] | [] |
example-79 | 18575136 | [
{
"id": "passage-79",
"type": "abstract",
"text": [
"Genotoxicity evaluation of drinking water sources in human peripheral blood lymphocytes using the comet assay. The potential harm of organic pollutants in drinking water to human health is widely focused on in the world; more and more pollutant... | [
{
"id": "entity-79-0",
"type": "ADVERSE",
"text": [
"Genotoxicity"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "entity-79-1",
"type": "ADVERSE",
"text": [
"genotoxicity"
],
"offsets": [
[
411,
... | [] | [] | [] |
example-80 | 18843612 | [
{
"id": "passage-80",
"type": "abstract",
"text": [
"WITHDRAWN: Multi-agent chemotherapy for early breast cancer. BACKGROUND: There have been many randomised trials of adjuvant prolonged polychemotherapy among women with early breast cancer, and an updated overview of their results is presented. ... | [
{
"id": "entity-80-0",
"type": "DISEASE",
"text": [
"breast cancer"
],
"offsets": [
[
46,
59
]
],
"normalized": []
},
{
"id": "entity-80-1",
"type": "DISEASE",
"text": [
"breast cancer"
],
"offsets": [
[
175,
... | [] | [] | [] |
End of preview. Expand in Data Studio
Dataset Card for SCAI Disease
SCAI Disease is a dataset annotated in 2010 with mentions of diseases and adverse effects. It is a corpus containing 400 randomly selected MEDLINE abstracts generated using ‘Disease OR Adverse effect’ as a PubMed query. This evaluation corpus was annotated by two individuals who hold a Master’s degree in life sciences.
Citation Information
@inproceedings{gurulingappa:lrec-ws10,
author = {Harsha Gurulingappa and Roman Klinger and Martin Hofmann-Apitius and Juliane Fluck},
title = {An Empirical Evaluation of Resources for the Identification of Diseases and Adverse Effects in Biomedical Literature},
booktitle = {LREC Workshop on Building and Evaluating Resources for Biomedical Text Mining},
year = {2010},
}
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