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10,002,200 | The objective of this study was to determine if the relationship between dietary folic acid and liver folacin concentration could serve as a quantitative standard response curve for a folacin bioassay. This paper examines the time required for liver folacin depletion, the effect of the supplementation period on the range of the linear response and the precision of the standard curve. Male weanling Fisher strain rats were offered a low folacin diet for 31 days. At the end of the depletion period rats were assigned to diets containing 0. 0.25, 0.5, 1.0, 2.0 or 4.0 mg added folic acid/kg of diet. Total liver folacin was measured on three animals from each group after 2, 4, 7, 14, and 28 days on the repletion diets. The liver folacin response curves at 7, 14, and 28 days had a linear range of 4, 2, and 1 mg of folic acid per kg of diet with standard errors equal to 11, 6, and 7% of the slopes respectively. The 28 day repletion period gives the most sensitive standard range. These responses establish that liver folacin concentration is suitable for use as the response variable in the folacin bioassay. With appropriate controls the model should be useful for bioassay of folacin in natural materials. | [
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10,002,201 | Erythrocyte filterability, fragility, and membrane proteins in folic acid deficient guinea pigs. | [
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10,002,202 | The purpose of this study was to determine if erythrocytes from folic acid-deficient guinea pigs could be used as a model for the study of defects which have been reported in megaloblastic anemic patients. Reported defects include decreased deformability and abnormal membrane proteins. Red cell filterability was studied with polycarbonate sieves and cellulose filters. Membrane proteins were analyzed by polyacrylamide gel electrophoresis in sodium in sodium dodecyl sulfate. Severe folate deficiency in guinea pigs caused no change in erythrocyte filterability or membrane proteins. Thus, the defects which have been reported in human folic acid or vitamin B-12 deficiency are not present in all animals with the same nutrient deficiency. Folate deficiency, however, did cause guinea pig erythrocytes to be markedly less susceptible to hypotonic lysis than cells from control animals, a feature which is not characteristic of human megaloblastic anemia. | [
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10,002,203 | Ethanol ingestion during pregnancy: effects on pregnant rats and their offspring. | [
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10,002,204 | A dose-response effect of ethanol intake on pregnant rats and their offspring has been studied. Ingestion of 36% ethanol diet reduced daily food consumption and attenuated gain in body weight relative to mothers fed control diet ad libitum. Mean values of survived litter size and body weight of offspring were significantly less than those of controls, although pair-fed controls ingested the same amount of food as ethanol-fed mothers. Offspring of 36% ethanol-fed animals failed to "catch up" in body weight relative to control pups. In contrast, feeding of 20% or 13% ethanol liquid diet did not adversely affect mothers and their offspring. Finally, administration of ethanol as 20% v/v drinking solution ad libitum resulted in decreased food intake as well as gain in body weight of pregnant rats and their offspring. The data suggest that ethanol ingestion in relatively smaller doses had no effect on maternal weight, litter size survival and growth of offspring, whereas relatively high ethanol doses adversely affected pregnant rats and their offspring. | [
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10,002,205 | Managing the health of the employee. | [
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10,002,206 | In summary, we now visualize the ideal preventive-health program as one which identifies target subpopulations with precision; intervenes in those populations with selectivity based on anticipated yield; modifies and tailors each intervention to maximize its individual effectiveness; and delivers the whole program through health-care delivery machinery that can itself be managed for maximum efficiency. This cannot be done without sophisticated information processing capability which permits the individualization of intervention. Consequently, most prevention and health maintenance efforts in the work setting are, for a time at least, going to have to be satisfied with less than ideal characteristics and less than optimum cost-effective ratios. That does not mean that there is nothing that can be done, or that all current programs are obsolete, or that no results can be achieved. It does mean that professionals and managers who are planning and directing such programs will increase their success to the extent that their programs can be made consistent with the principles involved, to the extent that all programs can be tailored to fit individual employee circumstances, and to the extent that the whole health-care management effort can be integrated into one smoothly functioning, efficient system. | [
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10,002,207 | Routine chest x-ray examinations in occupational medicine. | [
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10,002,208 | Epidemiology in the workplace: the problem of misclassification. | [
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10,002,209 | Strategies for recognition and quantification of misclassification are presented. Misclassification occurs when a subject is placed in the wrong "exposure" or the wrong "outcome" category as a result of the failure of an index measurement to reflect exposure or disease accurately. Data from a Health Hazard Evaluation illustrate how misclassification may result in an unwarranted etiologic assumption. Data from a lung cancer screening program illustrate how misclassification may result in erroneous estimates of disease prevalence. | [
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10,002,210 | Executive work perceptions and the quality of working life. | [
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10,002,211 | Stress in the police service. | [
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10,002,212 | In this study, the sources of stress among supervisory police officers were explored. It was found that one of the major sources of stress across all managerial levels among the police was the perception that the police service was inhibited by unnecessary bureaucratic and outside obstacles, e.g., increased paperwork, interdepartmental politics, lack of adequate planning and resources and the inability of the courts to prosecute offenders. It was also found that junior and middle supervisory police officers were adversely affected by lack of available manpower and long working hours, whereas senior officers were affected more by the conflict in maintaining positive policing as well as good community relations. | [
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10,002,213 | Smoking and duration of asbestos exposure in the production of functional and roentgenographic abnormalities in shipyard workers. | [
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10,002,214 | Functional and roentgenographic abnormalities in 131 asbestos-exposed shipyard workers were assessed in terms of duration of asbestos exposure and smoking history to determine the relative contributions of these factors. Both exposure and smoking contributed to the frequency of abnormalities in FEV1 and FVC. In contrast, airways obstruction (FEV1/FVC less than 70%) was unrelated to exposure but correlated closely with smoking. Abnormalities in DLCO were minimally associated with asbestos exposure, but were strongly related to smoking history, suggesting that diffusion impairment in these workers is more likely to be related to smoking and emphysema than to interstitial disease. Significant roentgenographic pleural abnormalities were associated with both duration of exposure and smoking. Interstitial disease did not correlate with exposure and was only mildly associated with smoking. Smoking contributes to many of the functional and roentgenographic abnormalities in asbestos-exposed workers. | [
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10,002,215 | Orienting medical students in occupational medicine. | [
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10,002,216 | Once again medical schools are actively putting together training programs in occupational medicine. Government funding is making it possible to add to the curriculum some interesting programs which introduce medical students to occupational medicine. The key to lasting success of any such undergraduate program lies in the cooperation of local industries in allowing students to make on-site plant tours. Additional interest and assistance from a large industrial union, a major workers' compensation carrier, and related government agencies have helped solve our unique needs in this field. | [
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10,002,218 | Consideration regarding infection during hospital employment. | [
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10,002,219 | Among the most important responsibilities of a hospital's employees' health service is the prevention or prompt identification of infectious illnesses among staff members. Infections constitute a major health hazard of hospital employment and, both intrinsically or as a consequence of subsequent transmission to hospitalized patients, can have devastating consequences. The risks associated with tuberculosis, viral hepatitis, rubella, herpes, meningococcal disease, and scabies are generally acknowledged and methods of control have been suggested. In addition, immunizations against diphtheria and influenza have been advised under certain circumstances. Respiratory syncytial virus and pertussis probably account for some upper respiratory tract illnesses among personnel and may lead to serious morbidity in pediatric patients. Laboratory-acquired infections can be diverse and exotic. Control measures should include surveillance, appropriate immunizations, epidemiologic investigation coordinated with infection control, antibiotic prophylaxis when indicated and environmental safeguards. | [
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10,002,220 | Lung cancer rates and the heights of miners. | [
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10,002,221 | Seminar on antibiotics VIII chloramphenicol. | [
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10,002,222 | Identification of androgen-dependent glycoproteins in the hamster epididymis and their association with spermatozoa. | [
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10,002,223 | Androgen-dependent epididymal proteins were investigated in the hamster. The stimulation of labelled amino acid incorporation, as well as the colour intensity of bands stained with Coomassie Blue after electrophoresis of the epididymal cytosol from castrated animals with and without androgen replacement, were used as semi-quantitative criteria for evaluation. These techniques allowed the identification of 6 androgen-sensitive bands (EP) with the following relative electrophoretic mobilities with respect to albumin: EP1 = 0.8; EP2 = 1.11; EP3 = 1.21; EP4 = 1.31; EP5 = 1.52; EP6 = 1.63. The proteins EP1, EP3 and EP4 were also found in fluid from the cauda epididymidis. Extraction of spermatozoa from the distal corpus and cauda epididymidis with 0.25 and 0.5 M-NaCl yielded appreciable amounts of EP2 and EP3 but these bands were not detected in extracts of spermatozoa from proximal segments. The approximate molecular weights were 651 400 for EP1, 42 500 for EP2, 23 800 for EP3, 20 400 for EP4, 26 100 for EP5 and 41 000 for EP6. All bands stained as glycoproteins with periodic acid--Schiff reagent. | [
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10,002,224 | Relation of electrical activity to luminal transport in the cauda epididymidis of the rat in vitro. | [
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10,002,225 | Droplets of stained paraffin oil were injected into the lumen of the rat cauda epididymidis through a microcapillary in vitro at a mean distance of 36 /+- 8 cm from the beginning of the ductus deferens. The location of a droplet was marked on a 6-channel recorder graph after each event of electrical activity of the wall musculature. Transport of the droplets consisted of pendular movements. The droplet moved in the direction of the spread of electrical activity then returned almost to its original position during reflux. The net distance for transport was dependent on the direction of the spread of activity and on the percentage of the non-propagating activity. The mean probability for the spread of the electrical activity towards the ductus deferens between the pairs of the electrodes was 0.54 and the mean net transport was 6.2 /+- 1.8 )s.e.m.) mm/h, towards the ductus deferens in 7 out of 10 ducts. | [
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10,002,226 | Structure and gametogenic potential of seminiferous tubules in ageing mice. | [
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10,002,227 | The gametogenic potential of young male CBA/Ca mice aged 4-5 months was compared with that of animals 20-23 months of age which had recently ceased to sire offspring. The older mice had substantially lower circulating levels of testosterone and smaller testes. Testicular and epididymal spermatozoa were reduced in number, had more abnormal forms and fewer were progressively motile. Ageing seminiferous tubules varied in the degree of functional atrophy from complete depletion of germ cells to maintenance of sperm production. They were enclosed by a thickened basal lamina and more collagenous connective tissue and occasionally allowed the penetration of lanthanum between Sertoli cells into the ad-luminal compartment. There was no evidence of autosensitization to sperm antigens. | [
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10,002,228 | Time relations of squirrel monkey (Saimiri sciureus) sperm capacitation and ovum maturation in an in-vitro fertilization system. | [
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10,002,229 | First polar body expulsion in the squirrel monkey ovum occurred at an average of 13.1 h after hCG injection when observed in culture but could occur as early as 5 h after hCG. the mean time for extrusion of the second polar body was 4.7 h after insemination of the culture with freshly ejaculated spermatozoa (16.3 h after hCG). The earliest time, and therefore also that of sperm capacitation, was 2 h after insemination. First cleavage occurred 16.2 h after insemination. | [
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10,002,230 | Analysis of stage-specific protein synthesis during spermatogenesis of the mouse by two-dimensional gel electrophoresis. | [
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10,002,231 | Cells were labelled by intratesticular injection of [35S]methionine. After 14-16 h the relative rates of incorporation of label in spermatocytes, early spermatids and late spermatids were 10:2:1 respectively. Approximately 15% of the soluble (100 000 g supernatant) and 20% of the particulate proteins solubilized by NP-40 (from the 100 000 g pellet) that were detectable on two-dimensional gels showed stage-specific synthesis. A large number of proteins were detectable only in post-meiotic cells and may be valuable for studying the control of gene expression in haploid cells. | [
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10,002,232 | Inhibition of the guinea-pig sperm acrosome reaction by a low molecular weight factor(s) in epididymal fluid and serum. | [
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10,002,233 | In protein-deficient minimal culture medium, acrosome reactions of motile guinea-pig spermatozoa were first evident after 30 min and maximal by 2 h. Addition of 5% (v/v) of guinea-pig serum filtrate or human plasma filtrate, obtained by passing these fluids through an Amicon UM-2 ultrafiltration membrane, prevented the sperm acrosome reaction during a 4-h incubation, but did not inhibit sperm motility. A similar inhibitory effect was found in porcine epididymal fluid. The factor(s) in porcine epididymal fluid effectively inhibited acrosome reactions if it was added to uncapacitated spermatozoa but failed to decapacitate sperm cells capacitated in Ca2+-free medium. Preliminary characterization of the factor(s) in porcine epididymal fluid indicate that it is a small organic molecule, stable to heat (90 degrees C), soluble in methanol, sparingly soluble in ethanol and insoluble in ether, chloroform or acetone; it also appears to have no net charge at pH values between 4 and 10. | [
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10,002,234 | Separation of sperm pairs and sperm-egg interaction in the opossum, Didelphis virginiana. | [
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10,002,235 | Uterine blood flow and uterine arterial, venous and luminal concentrations of oestrogens on days 11, 13 and 15 after oestrus in pregnant and non-pregnant sows. | [
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10,002,236 | Concentrations of oestradiol-17 beta and oestrone were measured in the uterine arterial and venous blood of anaesthetized sows on Days 11, 13 or 15 of the oestrous cycle or of pregnancy. Uterine arterial blood flow and the amounts of oestradiol-17 beta and oestrone in uterine flushings were determined in the same animals. In pregnant animals arterial and venous concentrations were significantly different (P less than 0.05) for oestradiol-17 beta on Days 11 and 13 and for oestrone on Day 15. Uterine content of both steroids was consistently greater in pregnant than in non-pregnant animals with a peak on Day 13. Uterine arterial blood increased from Day 11 to 13 of pregnancy then declined (P less than 0.08) by Day 15; no change in uterine blood flow occurred on the corresponding days of the oestrous cycle. | [
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] |
10,002,237 | Morphology, histology and steroid hormones of the gonads in intersex pigs. | [
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10,002,238 | Studies of 3 genetically female, intersex pigs revealed that only one showed oestrous cycles and lordosis, the other 2 exhibited various components of male sexual behaviour. Each uterus was a patent bicornuate structure, but 5 of the oviducts were incompletely formed. Two of the animals had bilateral ovotestes, whilst the third had a functional ovary on the right and an ovotestis on the left. The small ovarian portion of each ovotestis contained Graafian follicles which did not respond to a systemic injection of PMSG. The major portion of each ovotestis consisted of extensive interstitial tissue and seminiferous tubules devoid of germ cells. A structure closely resembling an epididymis adjoined the ovotestes. Concentrations of oestradiol and progesterone in plasma corresponded with those expected in the follicular phase of an oestrous cycle, but concentrations of testosterone represented approximately one-tenth of the values found in mature boars. | [
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10,002,239 | In-vitro zona-lytic activity in uterine fluid from ovariectomized mice treated with oestradiol-17 beta and progesterone. | [
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10,002,240 | Mouse embryos collected before implantation were incubated in vitro for 24 h with fluid rinsed from the uteri of ovariectomized female mice injected with progesterone, oestradiol-17 beta + progesterone, oestradiol-17 beta + progesterone, or oestradiol-17 beta alone. Although none of the zonae was completely dissolved, those incubated in fluid from animals treated with oestradiol + progesterone were subsequently more soluble in sodium thiocyanate (NaSCN) than those incubated similarly in control buffer, indicating a sublytic change during the incubation with uterine washings. Zonae incubated in fluid from animals injected with either hormone alone did not undergo such a change. | [
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10,002,241 | Motor activity of the human Fallopian tube in vitro in relation to plasma concentration of oestradiol and progesterone, and the influence of noradrenaline. | [
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] |
10,002,242 | The contractile pattern of the human Fallopian tube was studied in preparations from the ampullary and isthmic regions mounted in an organ bath for measurement of longitudinal and circular smooth muscle activity. The material was obtained during the follicular, ovulatory, and luteal phases of the cycle as defined primarily from plasma oestrogen and progesterone values. The frequency of the spontaneous contractions increased progressively during the follicular phase to become maximal around ovulation. There was no consistent difference between isthmus and ampulla; the circular musculature had a higher frequency than the longitudinal during the ovulatory phase. Noradrenaline (3 x 10(-6) M) in general potentiated the difference in frequency seen between the ovulatory phase on the one hand and the follicular and luteal phases on the other. Contractile activity, assessed by planimetric integration of the curve on the pen-recorder trace, increased markedly during the ovulatory phase in all types of smooth muscle preparations. Exogenous noradrenaline inhibited spontaneous motor activity in preparations from pregnant or post-menopausal women or from women taking combined-type oral contraceptives. This effect was most marked in the circular muscle. Thus the different regions of the human Fallopian tube in vitro show various patterns of spontaneous motor activity in relation to the plasma steroid concentrations furing the menstrual cycle. Responses to exogenous noradrenaline also varied, indicating that the effects of endogenous noradrenaline released from sympathetic nerves may vary similarly. | [
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10,002,243 | Prolactin response in beef cows and heifers suckling one or two calves. | [
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10,002,244 | Blood was collected, at 5-min intervals for 3 h, via jugular cannulation every 14 days during the first 4 months post partum from beef cows and heifers, 4 suckling 2 calves and 4 suckling 1 calf. Calves were isolated from the dams to prevent suckling for approximately 4 h before and 2 1/2 h during sampling to obtain baseline values for prolactin, measured by radioimmunoassay. During the last 30 min of sampling, calves were allowed to suck. Milk samples were also collected at 28-day intervals from 60 females, 30 with twins and 30 with single calves. beginning 2 weeks after calving and continuing until calves were weaned at 180 days of age. No differences were observed between dams with 1 and 2 calves for baseline plasma prolactin level or for prolactin response to the suckling stimulus by 1 or 2 calves. However, milk prolactin concentration was significantly higher (P less than 0.01) for dams with 2 calves, probably reflecting the more frequent suckling that occurs with twins. Milk prolactin value in this study was not highly correlated with the post-partum interval to first ovulation from another study on these animals. It is concluded that prolactin is not significantly higher (P less than 0.01) for dams with 2 calves, probably reflecting the more frequent suckling that occurs with twins. Milk prolactin value in this study was not highly correlated with the post-partum interval to first ovulation from another study on these animals. It is concluded that prolactin is not significantly higher (P less than 0.01) for dams with 2 calves, probably reflecting the more frequent suckling that occurs with twins. Milk prolactin value in this study was not highly correlated with the post-partum interval to first ovulation from another study on these animals. It is concluded that prolactin is not the primary factor controlling the longer post-partum interval to first ovulation in beef cattle with twins. | [
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10,002,245 | Effects of the uterus and mid-pregnancy conceptus on luteal lifespan of the rat. | [
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10,002,246 | Hysterectomy on or after Day 10 resulted in a quick return of pseudopregnant rats to oestrus but the interval to oestrus in pregnant rats was significantly longer (P less than 0.01), indicating that the gravid uterine horn interfered with uterine-induced luteolysis by Day 10. When pseudopregnant rats were injected with extracts of conceptuses or pregnant rat serum (PRS), samples collected on Days 10 or 12 of pregnancy delayed the return to oestrus (P less than 0.01 for conceptus extracts, P less than 0.05 for PRS) and serum progesterone concentrations on Day 13 of pseudopregnancy were higher (P less than 0.01) than in controls. Bioassays utilizing mammary development or inhibition of oestrus in virgin cyclic rats as endpoints failed to detect lactogenic activity in Day 10 conceptus extracts or PRS, and radioreceptor assays using bovine prolactin (NIH-B5) as a standard showed that Day 10 extracts had only about 2--3% of the lactogenic activity found in Day 12 extracts. Injections of dilutions of Day 12 extracts with 2 or 4 times the lactogenic activity as Day 10 extracts did not extend pseudopregnancy. These results suggest that by Day 10 the conceptus produces a factor capable of interfering with luteolysis and that this factor is not placental lactogen. | [
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10,002,247 | Survival of preimplantation embryos in the uteri of mice induced to superovulate and subsequently ovariectomized. | [
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10,002,248 | The effect of ovariectomy-induced hormonal deprivation for 3, 5, 7 or 9 days on the capacity of the mouse uterus to maintain large numbers of blastocysts was studied. Both the percentage of pregnant females and the number of embryos per female decreased from 90% with 18.89 embryos per female after 3 days to 40%, with 4.63 embryos per female, after 9 days of hormonal deprivation. The capacity of embryos from superovulating donors to implant in pseudopregnant recipients was unimpaired during the first 5 days of hormonal deprivation but was significantly impaired after 7 days. | [
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10,002,249 | Myoelectrical changes in the uterus of the sheep around parturition. | [
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10,002,250 | Myoelectrical activity in the uterus of late-pregnant sheep was recorded by the chronic implantation of bipolar electrodes in the myometrium. Three distinct patterns of electrical activity were recognizable: irregular trains of action potentials (greater than 120 sec), long spike bursts (7--120 sec), or short spike bursts (less than 7 sec) each exhibiting high (greater than 100 muV) or low (50--100 muV) amplitude. The duration of spike activity was expressed as the myoelectrical index (MI), i.e. the fraction of the hour during which a given category of activity is exhibited. The increase in the overall MI which represents daily average values regardless of the class of amplitude from 72 h pre partum up to parturition was significantly (P less than 0.05) more pronounced in the uterine horn than in the body of the uterus. During the last 6--7 days of gestation high-amplitude irregular trains and long spike bursts were significantly (P less than 0.05) more frequent than these activity patterns with low amplitude. Regardless of the amplitude, the incidence of irregular trains began to decline rapidly 48 h pre partum with an abrupt cessation following parturition. The frequency of long spike bursts increased 72 h pre partum to reach a maximum which coincided with parturition. | [
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10,002,251 | Tomorrow's medicine: art and science or commerce and industry? | [
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10,002,252 | Plasma concentrations of progesterone and 13,14-dihydro-15-keto prostaglandin F-2 alpha in pregnant, pseudopregnant and hysterectomized pseudopregnant mice. | [
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10,002,253 | Hysterectomized pseudopregnant mice had plasma progesterone concentrations on Days 6, 8, 10 or 12 after mating that were greater (P less than 0.05) than those of intact pseudopregnant mice and lower (P less than 0.01) than those of pregnant mice. Concentrations of 13,14-dihydro-15-keto-prostaglandin F-2 alpha on Days 6, 7, 8, 9 or 10 after mating were lower (P less than 0.05) in pregnant and higher (P less than 0.01) in intact pseudopregnant mice than in hysterectomized pseudopregnant mice. The results support the conclusion that there are uterine and extra-uterine luteolytic mechanisms which are mediated by prostaglandin and are perhaps functional by Day 6 of pregnancy. | [
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10,002,257 | Business and medicine: the pursuit of human health. | [
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10,002,258 | Resident preferences for the clinical teaching of ambulatory care. | [
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10,002,259 | The content and teaching behaviors of clinical teaching in ambulatory care and, in particular, in family practice centers are important to residents as they attempt to learn the varied aspects of patient care. This paper is based on a study of family medicine residents' preferences for the content areas of family medicine emphasized by those attending physicians perceived by the residents as the "best" clinical teachers in their respective centers. Also included in the study were the specific teaching behaviors of those same clinical teachers. A statistical analysis of the preferences of residents provided an indication of the dimensions of clinical teaching in resident education. Further, certain individual characteristics of residents were found to influence their perceptions. It was concluded that selected content areas should receive more emphasis and that the human aspects of clinical teaching are more important than technical teaching skills. These perceptions were helpful in suggesting ways of improving the teaching of residents and faculty development. | [
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10,002,260 | Personality characteristics of women entering medical school over a 10-year period. | [
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] |
10,002,261 | Personality characteristics of entering women medical students, as determined by their responses to the Omnibus Personality Inventory and the Minnesota Multiphasic Personality Inventory, are similar over the past decade. These women, as in the past, are independent, socially outgoing, sensitive, concerned about others, optimistic, well adjusted, and active and possess a positive self-image. Changing societal attitudes toward women's roles and the increased numbers of women admitted to medical school have not resulted in more diversity of personality types among women students. Rather they have opened the door to larger numbers of women with personalities similar to those of women entering a decade ago. Reasons for the difficulties that women students express today in finding role models among their faculty are suggested. | [
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10,002,262 | Faculty and house staff attitudes toward cancer status and comparison. | [
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] |
10,002,263 | This study describes a survey of attitudes toward cancer held by faculty and house staff physicians in a major teaching hospital. The instrument was designed to measure the two groups' (a) responses to declaratory statements about cancer and cancer patient management, (b) anticipated reactions to situations involving cancer, and (c) perceptions of each other relative to cancer-oriented issues. Data obtained from this project indicated significant differences between the perceptions of faculty and house staff members as to their counterpart's approach to cancer. In addition, the study has specific implications for increased attention toward attitudes and interpersonal communication as factors for improved cancer education in medical schools. | [
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10,002,264 | Effect of audiovisual cancer programs on patients and families. | [
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10,002,265 | Four new audiovisual programs about cancer and cancer treatment were evaluated. A total of 240 cancer patients, their families, and their friends were asked to complete self-report questionnaires before and after watching a program to determine the effects of the program on their knowledge of cancer, anxiety levels, and perceived ability to communicate with the staff. Education and race were the only demographic or medical variables that contributed to knowledge scores. Patients' anxiety levels were significantly lower than those of families. Neither anxiety nor knowledge was a function of time from diagnosis. This study demonstrates that audiovisual programs can effectively increase patients' understanding of their disease, decrease anxiety, and facilitate communication with staff. | [
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] |
10,002,266 | The new MCAT and its relationship to medical student performance-year two. | [
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10,002,268 | Differences in empathy: a preliminary analysis. | [
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10,002,269 | Using interaction analysis to evaluate the faculty in a human behavior course. | [
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10,002,270 | Family practice. | [
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10,002,271 | Radiation therapy. | [
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10,002,272 | Broadcasting science and medical news: the responsibilities and obligations. | [
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10,002,273 | Catamenial pneumothorax. | [
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10,002,274 | Seminar in perinatology: respiratory distress due to listeriosis. | [
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] |
10,002,275 | Radiologic seminar CCXVIX: Intrarenal colic -- a common problem with an unusual presentation. | [
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] |
10,002,276 | Taste and smell: the neglected senses. | [
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10,002,277 | The biological parabola: a look at serum cholesterol. | [
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10,002,278 | Nitrous oxide-oxygen sedation. | [
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10,002,279 | Antiarrhythmic agents during pregnancy. | [
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10,002,280 | Sleep paralysis and nocturnal seizure disorder. | [
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] |
10,002,281 | Overdose of benzodiazepines. | [
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10,002,283 | The advantages of small-gauge spinal needles. | [
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10,002,284 | Intravenous potassium chloride therapy. | [
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10,002,285 | Methacholine challenge. | [
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] |
10,002,286 | Medical students and medical school. | [
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10,002,287 | Bromocriptine reduces pituitary tumor size and hypersection. Requiem for pituitary surgery? | [
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10,002,288 | Twelve patients with pituitary tumor whose prior treatment included surgery and radiotherapy in four, surgery alone in four, radiotherapy alone in one, and none in three were studied. Nine had hyperprolactinemia, two had elevated serum growth hormones, and one had no pituitary hormone excess. Visual field defects were present in six. All had pituitary-gonadal insufficiency manifested as impotence or amenorrhea. All were tested with bromocriptine, 7.5 to 25 mg daily, and followed up for eight to 27 (mean 15) months. Serum prolactin levels decreased to normal in seven of nine patients. Serum growth hormone values were normalized in both acromegalics. When hormone levels were reduced to normal, pituitary tumor size decreased. Vision was restored to normal in five of six patients, including one patient with pituitary tumor but no pituitary hormone excess. Bromocriptine corrects the physiological defects associated with pituitary tumors that have been incompletely treated with surgery, radiotherapy, or both and may be a useful primary treatment for patients with pituitary tumors. | [
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10,002,289 | An evaluation of a plastic strip thermometer. | [
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10,002,290 | The Clinitemp Fever Detector (a registered trademark for the Clinitemp Co, Indianapolis) is a plastic strip thermometer designed to be placed on the forehead and to detect body temperature by changing color. In a sample of 613 patients, we evaluated the ability of the Clinitemp to detect fevers detected by traditional mercury/glass thermometers. When a Clinitemp reading of 37.8 degrees C (100 degrees F) was used to demark fever, the Clinitemp detected 34% of the clinically significant fevers detected by the mercury/glass thermometers. The sensitivity of the Clinitemp rose to .81 when a Clinitemp reading of 37.2 degrees C (99 degrees F) was used to demark fever. The accuracy of the Clinitemp was affected by variations in ambient air temperature. A reassessment of previously published evaluations of plastic strip thermometers suggest that our results are consistent with other experimental findings. We conclude that the Clinitemp is unacceptable as a substitute for the mercury/glass thermometer. | [
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10,002,291 | Duration of vidarabine therapy in biopsy-negative herpes simplex encephalitis. | [
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10,002,292 | Vidarabine therapy reduces mortality due to herpes simplex encephalitis (HSE) from 70% to 40% at one year. Treatment with vidarabine is commonly terminated five days after biopsy in suspected HSE if herpes simplex virus is not isolated from the biopsy specimen. However, as demonstrated by this case report, virus distribution in brain tissue may be patchy, even within the temporal lobe. In addition, several technical factors in the process of virus isolation can result in falsely negative results at five days. To protect this subgroup of patients with HSE, a full ten-day course of antiviral therapy should be considered for patients with focal encephalitis whose biopsy results are negative, provided that HSE remains the principal diagnostic possibility. However, the potential benefit of vidarabine treatment must be weighed against the risk of side effects, particularly cerebral edema. For optimum care, patients with presumed HSE should be transferred to centers whose personnel have expertise in the diagnosis and management of this disease. | [
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10,002,293 | Herpes simplex virus encephalitis. | [
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10,002,294 | Platelets and the environment. | [
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10,002,295 | The diverse nature of cancer cells: one reason therapy can fail. | [
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10,002,296 | Pediatric CVAs linked to lipid abnormalities. | [
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] |
10,002,297 | Taste loss persists after head/neck irradiation. | [
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10,002,298 | Phenylpropanolamine. | [
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] |
10,002,299 | Treatment of rattlesnake bites. | [
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