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10,006,101 | A life-span study was carried out on longevity, pathologic lesions, growth, lean body mass and selected aspects of muscle of barrier-maintained SPF Fischer 344 rats fed either ad libitum (Group A) or 60% of the ad libitum intake (Group R). Food restriction was as effective in prolonging the life of already long-lived S... | [
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10,006,102 | Early light microscopic changes in chronic progressive nephrosis in several strains of aging laboratory rats. | [
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10,006,103 | The kidneys of 441 full-lifespan rats of Wistar (WAG/Rij) and Brown Norway (BN/Bi) strains and a Sprague-Dawley stock were evaluated histologically for chronic progressive nephrosis. Age- and strain-related susceptibility to chronic progressive nephrosis, in terms of degree of lifetime pathological change, was characte... | [
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10,006,104 | Intestinal morphology and cell production rate in aging rats. | [
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10,006,105 | Age-related changes in the gut were investigated in male gnotobiotic rats, living in a controlled and constant environment until death. Parameters of the regenerative compartment of the jejunum and ileum were the cell production rate (measured by a stathmokinetic technique), the number of crypts, and the crypt:villus r... | [
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10,006,106 | Brain damage, stress, and life span: an experimental study. | [
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10,006,107 | Mice received frontal pole transections or sham operations, and approximately half in each group experienced cold stress five times throughout their lives. On two occasions certain selected animals were subjected to cold + restraint stress. Neither the brain lesions nor the cold stress affected life span. The stressors... | [
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10,006,108 | Wechsler Memory Scale Scores, selective attrition, and distance from death. | [
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10,006,109 | Age differences in mental synthesis. | [
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10,006,110 | In a series of three experiments, a mental synthesis task was administered to groups of college students and older adults. Simple symmetrical or asymmetrical straightline patterns were divided into two parts; the two parts were presented either sequentially or simultaneously. Participants were instructed to mentally co... | [
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10,006,111 | The relationship between classification and questioning strategies among adults. | [
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10,006,112 | Adults ranging from 30 to 90 were administered the Twenty Questions Task to evaluate questioning strategies and the Picture Pairing Test to assess classification preferences. With respect to the Twenty Questions Task, the results indicated that the percentage of constraint-seeking questions decreased while the percenta... | [
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10,006,113 | Age and iconic read-out. | [
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10,006,114 | Letter recognition was investigated in 16 young adults (mean age = 21) and in 16 older men (mean age =64) by exposing seven-letter strings for brief periods followed by a mask. Young adults were able to identify three letters at a rate of 27 msec per letter, a value which is typical of other reports. Any additional let... | [
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10,006,115 | Encoding strategies used by young and elderly adults in a keeping track task. | [
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10,006,116 | College students and older adults (mean ages 20.4 and 71.5 years) performed in a "keeping track" task that required them to recall, in response to probe questions, the most recently presented of each of a fixed set of categories. Questions alternated with presentations of new sets of items. Response accuracy, reaction ... | [
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10,006,117 | An analysis of the effect of aging on recognition memory. | [
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10,006,118 | The effect of aging on recognition memory processing is analyzed in terms of a stimulus-sampling model of recognition memory with parameters representing encoding effectiveness and stimulus overlap or interference. A standard study-test paradigm with a 2-alternative-forced-choice test was used with older and younger ad... | [
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10,006,119 | Age and academic-professional honors. | [
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10,006,120 | This report analyzes variations in the age distribution of individuals at selection to three prominent positions in the academic-professional community. Nobel prizewinner, president of a scientific or professional association, and president of a major research-oriented university. The mean ages of the individuals in ea... | [
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10,006,121 | Changing aged nonmetropolitan migration patterns, 1955 to 1960 and 1965 to 1970. | [
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10,006,122 | One type of population redistribution is discussed in this paper. It is the migration of older people between metropolitan and nonmetropolitan locations as it has occurred over two decades. Net migration studies have documented the metropolitan-to-nonmetropolitan turnaround but have not been able to connect the origin ... | [
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10,006,123 | An ecological model of mental health among small-town rural elderly. | [
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10,006,124 | The present study models the impact of three domains of environmental variables (ecological/architectural, psychosocial, and personal) on the mental health and well-being of 989 community-based rural elderly (65 years or older) in 18 small Kansas towns. Utilizing standard structured interview data, we employed a holdou... | [
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10,006,125 | The consequences of childlessness on the social-psychological well-being of older women. | [
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10,006,126 | On the other hand: some comments on Sigelman's palmistry. | [
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10,006,127 | Responding to a negative assessment by Daniel W. Sigelman of the social impact of current efforts to promote competition in the medical marketplace, Blumstein argues that, since the competitive strategy is designed to rationalize health care delivery, it should be evaluated independently of the issue of financing healt... | [
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10,006,128 | Regulation and competition: an examination of "the consumer choice health plan". | [
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10,006,129 | Legislation to enact the "Consumer Choice Health Plan" is promoted as a step toward competition and away from regulation. This characterization is misleading. The tax provisions in this plan include potentially beneficial reforms, but have offsetting effects that impair economic efficiency. The plan's regulatory provis... | [
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10,006,130 | Managerial innovation and health policy: theoretical perspectives and research implications. | [
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10,006,131 | Stimulated by a variety of external pressures, managerial innovation is likely to become more common in health care organizations. Relatively little is known, however, about the phenomenon. This paper develops a framework for the analysis of managerial innovation in health care organizations, based on the premise that ... | [
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10,006,132 | Legislating hospital bed reduction: the Michigan experience. | [
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10,006,133 | A variety of programs aimed at health care cost containment have been initiated at the state level. This article presents a case study of one state's effort to deal with health care cost issues, focusing on the formulation of adoption of legislation to reduce the number of hospital beds. The Michigan bed-reduction legi... | [
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10,006,134 | Contracting state mental hospital systems. | [
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10,006,135 | The predominant approach to contracting state mental hospital systems has been to close individual hospitals. Such a policy creates conflict between state government and the affected workers and communities. Closing of hospitals has been motivated by an implicit assumption on the part of state policy-makers that there ... | [
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10,006,136 | Improving health care policy research. | [
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10,006,137 | Interest in health care policy research has grown significantly over the past decade. This paper makes a number of suggestions for improving the quality of health care policy research and its influence on policymaking. These include suggestions for: 1) improving the way in which problems are identified and defined; 2) ... | [
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10,006,138 | A pyramid model of health manpower in the 1980s. | [
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10,006,139 | In little more than a decade, the problems and issues relating to the supply of, and demand for, skilled health manpower in the United States have shifted dramatically. Where the key words in the late 1960s were "shortage," "crisis," and "expansion of training capacity," the major concerns on the threshold of the 1980s... | [
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10,006,140 | Differences by sex in economic returns associated with physician specialization. | [
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10,006,141 | Women comprised only 8.8 percent of active physicians in the United States in 1977. However, recent trends in the sex composition of medical school classes indicate that women will make up at least one-fourth of total physician supply in the future. Consequently, the effect of sex-composition changes on the supply of p... | [
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10,006,142 | Economic dependency, health services, and health: the case of Lesotho. | [
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10,006,143 | This article is concerned with two factors affecting the health status of the people of Lesotho: (1) the nation's function as a reserve labor economy (that is, the primary source of income for about half the country's male labor force is employment in South Africa); and (2) the health care system (its size, composition... | [
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10,006,144 | Evaluation of the Robert Wood Johnson Health Policy Fellowship program: a synopsis. | [
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10,006,145 | Enterotoxin A and B production in strains of Staphylococcus aureus isolated from human beings and foods. | [
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10,006,146 | The production of enterotoxin A and B by strains of Staphylococcus aureus isolated from nasal swabs of healthy carriers, from lesions of hospital patients and from foods unconnected with outbreaks of food-poisoning was investigated. Sixty-six strains of S. aureus were obtained from human beings, two produced enterotoxi... | [
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10,006,147 | The effect of time in lairage on the frequency of salmonella infection in slaughtered pigs. | [
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10,006,148 | Groups of pigs were brought to an abattior by truck and approximately 25 were killed on each of the next 3 days. While the pigs were in lairage they were given water but were not fed. After slaughter the caecal contents of all pigs were cultured to detect Salmonella spp. The organism was isolated from 70% of 145 pigs k... | [
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10,006,149 | Is a bed centre in a hospital a hygienic hazard? | [
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10,006,150 | The contamination of linen and air in a bed centre, supply station and ward were compared, as well as the contamination of gowns used by the staff working in the 'clean' and the 'dirty' rooms of the bed-centre. The contamination of linen and air was low and there was no significant difference between the tested areas. ... | [
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10,006,151 | A comparison of the results of the brucellosis radioimmunoassay and other serological test in experimentally infected cattle. | [
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10,006,152 | The serology of 27 heifers found to be positive to culture after inoculation with Brucella abortus strain 544, was studied. Eighteen heifers had previously been vaccinated with strain 19 or strain 45/20 and nine were unvaccinated. Post-infection serum samples were tested for Brucella antibodies by radioimmunoassay (RIA... | [
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10,006,153 | Shigella species from Addis Ababa: frequency of isolation and in vitro drug sensitivity. | [
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10,006,154 | One hundred and five shigella isolates from Addis Ababa were studied to determine serogroup frequency and in vitro antibacterial drug sensitivity. About 70% of the isolates were Shigella flexneri followed by Sh. dysenteriae (15%), Sh. boydii (10%) and Sh. sonnei (5%). All or most of the strains were susceptible to ceph... | [
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10,006,155 | The sanitary condition of rural drinking water in a Nile Delta village. I. Parasitological assessment of 'zir' stored and direct tap water. | [
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10,006,156 | The bacterial flora of neonates with congenital abnormalities of the gastro-intestinal tract. | [
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10,006,157 | The development of the bacterial flora of neonates with congenital abnormalities of the gastro-intestinal tract was studied in 31 infants during the first 10 days of life. Specimens were collected from the umbilicus, mouth and gastro-intestinal tract on the pre-operative day, at operation and on post-operative days 1, ... | [
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10,006,158 | Influenza surveillance in England and Wales using routine statistics. Development of 'cusum' graphs to compare 12 previous winters and to monitor the 1980/81 winter. | [
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10,006,159 | Surveillance of influenza in England and Wales is made by monitoring weekly data. Principal indices are deaths, sickness-benefit claims (SBC), laboratory reports and observations from general practitioners (GPs). The 12 winter 1968/9 to 1979/80 have been studied to see which indices best described size and timing of in... | [
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10,006,160 | Observations on the epidemiology of lumpy skin disease in Kenya. | [
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10,006,161 | Lumpy skin disease virus strains isolated in Kenya over a period of some 20 years have proved to be serologically identical. They were indistinguishable by indirect fluorescent antibody and serum neutralization test from the South African Neethling and West African serotypes. These two serological methods proved of val... | [
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10,006,162 | Inhibition of human natural killer cell activity by cytophilic immunoglobulin G. | [
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10,006,163 | The natural killer (NK) cell activity of human peripheral blood mononuclear cells (PBL) was found to be increased after incubation at 37 degrees C for 2 hr. The observed increase was shown to be associated with release from inhibition by human serum factors, because incubation in autologous serum interfered with augmen... | [
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10,006,164 | Studies on natural killer (NK) cells. III. The effects of in vitro culture on spontaneous cytotoxicity of murine spleen cells. | [
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10,006,165 | In vitro culture of normal lymphohemopoietic cells is a complex event leading to the generation of a diverse group of effector cells. When murine spleen cells are cultured by themselves in fetal calf serum containing medium for up to 9 days, at least 3 distinct subpopulations of cytotoxic effectors can be distinguished... | [
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10,006,166 | Lysis of hapten-labeled cells by anti-hapten IgG and complement: effect of cell surface hapten density. | [
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10,006,167 | Rabbit anti-methotrexate (MTX) IgG antibody was used to study the effect of MTX density on sheep red cells on the lysis of cells by complement (C). Under conditions in which the density of IgG did not vary, the number of lytic IgG complexes remained approximately the same when the average distance between MTX molecules... | [
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10,006,168 | Ultrastructural events in the translocation of polymeric IgA by rat hepatocytes. | [
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10,006,169 | It has been proposed that polymeric IgA is translocated from plasma to bile across hepatocytes of the rat liver by a secretory component-mediated, vesicular transport. To define the ultrastructural details of the proposed transport mechanism, we employed peroxidase-labeled antibody immunocytochemistry to localize secre... | [
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10,006,170 | Dna isolated from DNA/anti-DNA antibody immune complexes in systemic lupus erythematosus is rich in guanine-cytosine content. | [
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10,006,171 | DNA fragments were isolated from DNA/anti-DNA antibody immune complexes of systemic lupus erythematosus. Hybridization experiments indicated that DNA isolated from immune complexes originates from human nuclear DNA. Two classes of DNA were identified by polyacrylamide gel electrophoresis. The m.w. of small fragments wa... | [
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10,006,172 | Human host response to Giardia lamblia. I. Spontaneous killing by mononuclear leukocytes in vitro. | [
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10,006,173 | To understand host resistance to Giardia lamblia infection, we investigated the capacity of human peripheral blood effector cells to kill G. lamblia trophozoites. Peripheral blood was obtained from 12 healthy, uninfected individuals without detectable IgG anti-G. lamblia antibody or known exposure to G. lamblia. Isolat... | [
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10,006,174 | Adoptive transfer of modulation of granuloma formation and hepatosplenic disease in murine schistosomiasis japonica by serum from chronically infected animals. | [
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0.04510911926627159,
0.011921576224267483,
0.03769944980740547,
0.13620470464229584,
0.03637... |
10,006,175 | The course of disease due to Schistosoma japonicum in C57BL/6J mice was examined. Animals infected with 25 cercariae of the Philippine strain of S. japonicum for 9 wk develop a peak portal hypertension of 13 +/- 0.6 cm H2O and mean hepatic granuloma area of 459 X 10(3) micrometers 2. By 30 wk, disease manifestations we... | [
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0.14601747691631317,
0.052... |
10,006,176 | Interactions of bacterial lipopolysaccharide with acute-phase rabbit serum and isolation of two forms of rabbit serum amyloid A. | [
0.030487526208162308,
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0.03132252022624016,
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0.05806... |
10,006,177 | Mixing lipopolysaccharide (LPS, Salmonella minnesota R595) with acute-phase rabbit serum (APRS) results in the formation of two types of complexes. The two complexes are separable from each other and from LPS by CsCl density gradient ultracentrifugation. LPS alone had density 1.38 g/cm3, complex 1.3 had density 1.3 +/-... | [
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0.07... |
10,006,178 | Lymphokine modulation of fibroblast proliferation. | [
0.058081790804862976,
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0.011311708949506283,
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10,006,179 | In an experimental model of interstitial nephritis resulting in fibrosis, lymphokines secreted by a common population of antigen-reactive T lymphocytes have been shown to exert a bidirectional influence on fibroblast proliferation and collagen synthesis. We report that these lymphokines can be chromatographically separ... | [
0.008847154676914215,
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0.059... |
10,006,180 | Determination of a glucose-containing tetrasaccharide in urine by radioimmunoassay. | [
0.032110150903463364,
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0.026351265609264374,
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0.00128443434368819,
0.044344... |
10,006,181 | A radioimmunoassay is described that allows rapid determination of a urinary oligosaccharide -- Glc alpha 1-6Glc alpha 1-4Glc alpha 1-4Glc [(Glc)4] -- at concentrations greater than 2 pmol/microliter. Antibodies produced in rabbits immunized with the phenethylamine derivative of (Glc)4 coupled to keyhole limpet hemocya... | [
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0.04324240982532501,
0.03563564643263817,
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0.09... |
10,006,182 | ELISA for antibody measurement: aspects related to data expression. | [
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0.0324341282248497,
0.... |
10,006,183 | In an ELISA for antitoxoplasma IgG (antigen-coated polystyrene beads, horseradish peroxidase-coupled IgG or staphylococcal protein A), 3 modes of expressing the analytical results were considered, i.e. end-point antibody titre, untransformed absorbance reading at a single sample dilution, and antibody-activity unit fro... | [
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0.06437826156616211,
0.049068... |
10,006,184 | Separation of mononuclear and polymorphonuclear leucocytes from human blood by the one-step Hypaque-Ficoll method is dependent on blood column height. | [
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0.01... |
10,006,185 | Further observations have been made in relation to separation of mononuclear (MN) and polymorphonuclear (PMN) leucocytes from human blood by the one-step procedure involving centrifugation of the blood on Hypaque-Ficoll medium. The distance separating the MN and PMN cell fractions was dependent on the height of the blo... | [
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0.005370655097067356,
0... |
10,006,186 | A cautionary note on the use of lentil lectin affinity chromatography in the presence of sodium deoxycholate. | [
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0.012382804416120052,
0.0... |
10,006,187 | When affinity chromatography with lentil lectin (LcH)-Sepharose was carried out in 0.5% (w/v) sodium deoxycholate (DOC), 10 mm Tris, pH 8.2, LcH consistently appeared in the 0.1 M alpha-methyl-mannoside (alpha-MeMan)-eluted fraction. Eluted LcH was recovered in both the control and specific immunoprecipitates with anti... | [
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0.0... |
10,006,188 | Development of solid-phase immunoassay using chemiluminescent IgG conjugates. | [
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0.05942492559552193,
0.04... |
10,006,189 | Solid-phase luminescent immunoassay (LIA) was studied using mainly aminobutyl-ethylisoluminol-IgG conjugates. Different solid-phase supports such as immunobeads, polystyrene balls and tubes gave comparable results although tubes were preferred in most of the assays because of the better linearity and reproducibility ob... | [
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0.01360367052257061,
0.045298218727111816,
0.04241... |
10,006,190 | Electron microscopic identification of Langerhans cells in the dermal infiltrates of mycosis fungoides. | [
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0.003304364625364542,
0.05585557... |
10,006,191 | The importance of the physical interaction between epidermal Langerhans cells and malignant cells in mycosis fungoides (MF) has been stressed recently. To further evaluate this concept, electron microscopic study was carried out to identify whether or not Langerhans cells are also present in the dermal infiltrates of M... | [
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0.029367558658123016,
0.00658990... |
10,006,192 | New melanogenesis and photobiological processes in activation and proliferation of precursor melanocytes after UV-exposure: ultrastructural differentiation of precursor melanocytes from Langerhans cells. | [
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0.06313... |
10,006,193 | Photobiological processes involving new melanogenesis after exposure to ultraviolet (UV) light were experimentally studied in C57 black adult mice by histochemistry, cytochemistry, and autoradiography. The trunk and the plantar region of the foot, where no functioning melanocytes were present before exposure, were expo... | [
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0.10123... |
10,006,194 | Retinoic acid modulation of ultraviolet light-induced epidermal ornithine decarboxylase activity. | [
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0.0484248... |
10,006,195 | Irradiation of skin with ultraviolet light of sunburn range (UVB) leads to a large and rapid induction of the polyamine biosynthetic enzyme ornithine decarboxylase in the epidermis. Induction of epidermal ornithine decarboxylase also occurs following application of the tumor promoting agent 12-0-tetradecanoylphorbol-13... | [
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0.06265957653522491,
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0.04761272668838501,
0.061573... |
10,006,196 | Isolation and lipid biochemical characterization of stratum corneum membrane complexes: implications for the cutaneous permeability barrier. | [
-0.03228918835520744,
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0.009709901176393032,
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0.0006914858822710812,
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0.030... |
10,006,197 | The melanin pigmentary disorder in a family with Hermansky-Pudlak syndrome. | [
-0.03567853942513466,
0.014290443621575832,
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0.031534988433122635,
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-0.... |
10,006,198 | The albinotic skin and hair of 2 patients with Hermansky-Pudlak syndrome were investigated by light and electron microscopy. Incubation of hairbulbs and epidermis in 1-dopa revealed a weak tyrosinase activity. The epidermal melanocyte population was of normal density. The most striking feature was the presence of numer... | [
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0.001624582801014185,
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0.06453738361597061,
-0.0741056427359581,
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10,006,199 | Psoriasis and the risk of cancer. | [
0.03810105472803116,
0.06615987420082092,
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0.04140103980898857,
0.006933326832950115,
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0.0385427363216877,
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-0.0439... |
10,006,200 | To test the validity of the common hypothesis that patients with psoriasis have an inherently lower susceptibility to cancer, we prospectively studied 1367 patients with severe psoriasis who enrolled in a clinical trial of oral methoxsalen photochemotherapy for treatment of psoriasis for an average of 3.2 yr. The incid... | [
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0.028858955949544907,
0.010573276318609715,
-0.02576853521168232,
0.03903184458613396,
-0.0127... |
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