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10,006,401 | Normal laughter is a unique human behavior with characteristic facial and respiratory patterns elicited by a variety of stimulus conditions. The neuroanatomy remains poorly defined but three levels seem likely: a) a cortical level; b) a bulbar, or effector, level; and 3) a synkinetic, or integrative, level probably at ... | [
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10,006,402 | Sociocultural determinants of the help-seeking behavior of patients with mental illness. | [
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10,006,403 | This descriptive study employed semistructured interviewing and questionnaire administration to delineate the sociocultural determinants of the help-seeking process in 48 psychiatric patients. The help-seeking process is considered in two stages. The first stage starts from the recognition of initial symptoms and ends ... | [
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10,006,404 | Family history of suicidal behavior among suicide attempters. | [
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10,006,405 | Efforts to predict suicide and attempted suicide are hampered by their relative rarity on the one hand and the inadequate specificity of clinical characteristics and relevant antecedent events on the other; that is, these features are found widely among the nonsuicidal as well. In an effort to further understand these ... | [
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10,006,406 | Bilateral electrodermal habituation-dishabituation and resting EEG in remitted schizophrenics. | [
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10,006,407 | This study examined bilateral electrodermal responding, heart rate, and resting EEG in schizophrenics who were not psychotic at the time of testing. Twenty-four carefully diagnosed, remitted schizophrenics were compared to 22 medical outpatient controls. Subjects were exposed to 17 pure tones; the 16th tone differed in... | [
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10,006,408 | Influence of innervation on the levels of noradrenaline and serotonin in the circumvallate papilla of the rat. | [
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10,006,409 | The levels and the distribution of monoamines within the rat circumvallate papilla have been studied. Noradrenaline was found in the connective tissue underlying the taste buds, whereas serotonin was located in the basal area of the gustatory epithelium but not inside the taste buds. Following denervation, noradrenalin... | [
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10,006,410 | Thalamic center for the lateral line system in the catfish Ictalurus nebulosus: evoked potential evidence. | [
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10,006,411 | By means of evoked potential methods, a lateral line center in the thalamus of the bullhead catfish is here identified. The locus of this lateral line center corresponds to the mechanoreceptive thalamic zone and/or torothalamic tract identified by anatomical means. The thalamic lateral line area responds to acoustic st... | [
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10,006,412 | Identification and localization of catecholamines in the nervous system of Limulus polyphemus. | [
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10,006,413 | The concentrations of various catecholamines in the nervous system of the horseshoe crab Limulus polyphemus have been determined by high-performance liquid chromatography with electrochemical detection. Dopamine, norepinephrine, epinephrine, and their precursor L-Dopa were present in appreciable quantities in discrete ... | [
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10,006,414 | Chemoreception in gastropod molluscs: electron microscopy of putative receptor cells. | [
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10,006,415 | Scanning and transmission electron microscopy of the external surface of the gastropod mollusc Pleurobranchaea californica has revealed a new exteroreceptor, characterized by dense cilia (ac.200/cell) that project from an intraepithelial soma and exhibit dilated, discoid-shaped tips. The exteroreceptor is found in high... | [
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10,006,416 | Neuritic growth and neuroma formation by an isolated molluscan ganglion. | [
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10,006,417 | The isolated, paired buccal ganglia of the snail Helisoma trivolvis were cultured in vivo (i.e., in host snails) for periods up to 377 days. Such ganglia typically become enveloped in a white mass of fibrous tissue which reaches a maximum plateau of size within four weeks. The scanning electron microscope revealed the ... | [
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10,006,418 | Developmental changes in the folate-dependent enzymes of de novo purine biosynthesis in rat brain. | [
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10,006,419 | The activities of the two folate-dependent enzymes in the de novo purine biosynthetic pathway (e.g., glycinamide ribonucleotide transformylase and aminoimidazolecarboxamide ribonucleotide transformylase), have been evaluated as a function of age in crude extracts from rat brain, liver, kidney, and spleen. The activitie... | [
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10,006,420 | Characterization of catecholamine-storage organelles in transplantable phaeochromocytoma and adrenal glands of rats. | [
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10,006,421 | The properties of the catecholamine-storing organelles from transplantable rat phaeochromocytoma and rat adrenal glands were compared by density gradient centrifugation. It was shown that tumour granules are more heterogeneous and less dense than adrenal granules. Both granule preparations can take up catecholamines an... | [
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10,006,422 | Characteristics of protein carboxyl methylation in the rat hypothalamus. | [
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10,006,423 | The formation of methyl-labeled S-adenosylmethionine (AdoMet) and methyl esters of endogenous methyl-acceptor proteins (MAPs) was studied in a synaptosomal preparation from the rat hypothalamus labeled with L-[methyl-3H]methionine. Incubation of synaptosomes with L-[methyl-3H]methionine resulted in a rapid labeling of ... | [
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10,006,424 | Choline uptake in cultured human Y79 retinoblastoma cells: effect of polyunsaturated fatty acid compositional modifications. | [
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10,006,425 | Choline uptake in Y79 human retinoblastoma cells occurs through two kinetically distinguishable processes. The high-affinity system shows little sodium or energy dependence, and it does not appear to be linked to acetyl CoA; choline O-acetyltransferase. When the cells are grown in a culture medium containing 10% fetal ... | [
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10,006,426 | Testosterone 5 alpha-reductase in spinal cord of Xenopus laevis. | [
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10,006,427 | Testosterone 5 alpha-reductase, the enzyme that converts testosterone to 5 alpha-dihydrotestosterone, is present in the spinal cord of Xenopus laevis. In adult males the enzymatic activity is optimal at pH 7.4 and 27 degrees C; the apparent Km is 2.0 x 10(-5) M and the Vmax is 10.0 pmol/mg protein/h. Enzymatic activity... | [
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10,006,428 | Acid:coenzyme A ligase in brain: fatty acid specificity in cellular and subcellular fractions. | [
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10,006,429 | We measured long-chain fatty acid: coenzyme A (CoA) ligase (EC 6.2.1.3) activity with four fatty acids in brain homogenates, and cellular and subcellular fractions to determine whether there are differences in activity that could be correlated with differences in fatty acid composition and metabolism. In rat brain homo... | [
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10,006,430 | On the significance of endogenous 3-methoxytyramine for the effects of centrally acting drugs on dopamine release in the rat brain. | [
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10,006,431 | 3-Methoxytyramine (3-MT) was measured in the striata of rats killed by microwave radiation. Apomorphine, gamma-butyrolactone (GBL), and reserpine decreased the 3-MT content. A slight but transient increase in 3-MT was observed after haloperidol. The turnover rate of 3-MT was unchanged 60 min after haloperidol treatment... | [
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10,006,432 | Phosphatidylserine enhancement of [3H]gamma-aminobutyric acid uptake by rat whole brain synaptosomes. | [
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10,006,433 | [3H]gamma-Aminobutyric acid ([3H]GABA) binding to purified lipids was examined in an organic solvent-aqueous partition system. In addition, the [3H]GABA binding capacity in the partition system was compared with the capacity of lipids to alter sodium-dependent [3H]GABA uptake into synaptosomes isolated from rat whole b... | [
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10,006,434 | Regional blood-brain barrier permeability to amino acids after portacaval anastomosis. | [
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10,006,435 | The influx of phenylalanine, tryptophan, leucine, and lysine across the blood-brain barrier of individual brain structures was studied in rats 7--8 weeks after a portacaval shunt or sham operation. The method involved a brief infusion of labeled amino acid in tracer quantity and quantitative autoradiography. The cleara... | [
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10,006,436 | Dopamine beta-hydroxylase and other glycoproteins from the soluble content and the membranes of adrenal chromaffin granules: isolation and carbohydrate analysis. | [
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-0.07635993510484695,
0.0... |
10,006,437 | Chromogranin A and two other proteins (A1 and A2) of the soluble proteins of bovine chromaffin granules were isolated by extraction from polyacrylamide gels after electrophoresis. The carbohydrate content of these proteins was 5%, with galactose, N-acetylgalactosamine, and sialic acid as the main sugars. Membranes of c... | [
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0.018825... |
10,006,438 | Deamination of 5-hydroxytryptamine by both forms of monoamine oxidase in the rat brain. | [
0.06074612960219383,
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0.030664948746562004,
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0.04839903861284256,
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0.07190... |
10,006,439 | Km and Vmax values of monoamine oxidase (MAO) A and B towards 5-hydroxytryptamine were determined for rat brain homogenates after the in vitro inhibition of one of the two forms by the selective inhibitors clorgyline and l-deprenyl. Km values of 178 and 1170 microM, and Vmax values of 0.73 and 0.09 nmol . mg protein-1 ... | [
0.05266299098730087,
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0.0... |
10,006,440 | Sympathetic regulation of circadian rhythm of serotonin N-acetyltransferase activity in pineal gland of infant rat. | [
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0.0363... |
10,006,441 | The circadian rhythms of serotonin N-acetyltransferase activity in the pineal glands of infant and adult rats were compared. The nighttime increase of N-acetyltransferase activity in the pineals of infant rats was blocked by removal of superior cervical ganglion or by pretreatment with reserpine, l-propranolol, and cyc... | [
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0.0450489... |
10,006,442 | The regional concentrations of S-adenosyl-L-methionine, S-adenosyl-L-homocysteine, and adenosine in rat brain. | [
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0.07... |
10,006,443 | The concentrations of S-adenosyl-L-methionine (SAM), S-adenosyl-L-homocysteine (SAH), and adenosine (Ado) were determined in whole brain and rat brain regions by HPLC. The whole brain contains, respectively, 22 nmol, 1 nmol, and 65 nmol of SAM, SAH, and Ado per g of wet tissue. Their distribution indicated that SAM and... | [
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0.03062320500612259,
0.0509821... |
10,006,444 | Generalized N-acetylneuraminic acid storage disease: quantitation and identification of the monosaccharide accumulating in brain and other tissues. | [
0.01207255944609642,
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0.003878... |
10,006,445 | Brain and other tissues from a patient with extensive neonatal ascites and clinical symptoms suggestive of a severe neurovisceral storage disorder were examined following autopsy for the accumulation of oligosaccharides. This carbohydrate analysis revealed the presence of large amounts (3--21) mumol/g fresh weight) of ... | [
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10,006,446 | Studies on the presence of angiotensin II in rat brain. | [
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10,006,447 | Angiotensin II-like immunoreactivity was extracted from brains of bilaterally nephrectomized rats with several different extraction procedures (90% methanol, distilled water, 6 M urea, 0.1 N HCl, and 2 M acetic acid). The activity was measured with radioimmunoassays using three different antisera, two of which had been... | [
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10,006,448 | Cellular level of purine compounds in ischemic gerbil brain by high performance liquid chromatography. | [
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10,006,449 | The cellular level of AtP and related compounds in ischemic gerbil brain was investigated by high performance liquid chromatography (HPLC). Brain samples were obtained in situ following ligation of the common carotid artery. AMP and ADP peaks in the brain extracts in the ischemic group became much larger whereas the AT... | [
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0.03... |
10,006,450 | The effects of chronic manganese chloride treatment expressed as age-dependent, transient changes in rat brain synaptosomal uptake of amines. | [
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0.11851... |
10,006,451 | As a result of chronic manganese treatment of rats from conception onwards, a decrease was observed in the uptake of dopamine, but not of noradrenaline or serotonin, by synaptosomes isolated from hypothalamus, striatum, and midbrain and in choline uptake by hypothalamic synaptosomes obtained from 70-90-day-old animals.... | [
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0.09610787034034729,
0.055989... |
10,006,452 | Effects of anticonvulsants on the formation of gamma-hydroxybutyrate from gamma-aminobutyrate in rat brain. | [
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0.01497... |
10,006,453 | The conversion of gamma-aminobutyrate (GABA) via succinic semialdehyde to gamma-hydroxybutyrate has been examined in rat brain homogenates. A number of anticonvulsants, including sodium valproate and phenobarbitone, inhibited this metabolic pathway. These results are interpreted in the light of the characteristics of a... | [
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10,006,454 | Monoamine oxidase-catalyzed metabolism of 3,4-dihydroxyphenylethylamine in the dopaminergic synaptosomes from rat corpus striatum. | [
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0... |
10,006,455 | This communication describes conditions under which the monoamine oxidase-catalyzed metabolism of 3,4-dihydroxyphenylethylamine can be assayed in dopaminergic synaptosomes from the rat striatum. In contrast to the activity of the isolated enzyme or that of free mitochondria, the synaptosomal reaction exhibits sigmoidal... | [
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0.0635... |
10,006,456 | Myoadenylate deaminase deficiency or not? Observations on two brothers with exercise-induced muscle pain. | [
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0.08... |
10,006,457 | This paper describes 2 brothers with increasingly severe exercise-induced muscle pain and stiffness, beginning in adolescence. Histochemical studies showed that myoadenylate deaminase activity was absent in the propositus, but present in his younger brother. Biochemical examination of muscle homogenates confirmed these... | [
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10,006,458 | Collagen types in neuromuscular diseases. | [
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10,006,459 | The striking proliferation of connective tissue characteristic of the muscular dystrophies can be attributed predominantly to an increase in endomysial and perimysial type III collagen. Carriers of muscular dystrophy occasionally revealed a slight increase in anti-type III collagen fluorescence, but no abnormalities in... | [
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0.0941... |
10,006,460 | The maturation of the ventral root-spinal cord transitional zone. Part 2. A quantitative ultrastructural study of the dynamics of its early development. | [
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0.0... |
10,006,461 | Stereological methods were used to calculate the proportions made up by the various tissue components of the transitional zone between C7 ventral spinal nerve rootlets and the spinal cord in Wistar albino rats at 1, 4 and 12 days after birth. The zone is about 20 micrometer deep at each age studied. Astrocyte processes... | [
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10,006,462 | Central core disease. Study of a family with five affected generations. | [
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0.03578830510377884,
-0.063... |
10,006,463 | A family is described in which at least 37 members in five generations living in Australia have suffered from a rare congenital myopathy--central core disease (CCD). Histochemical and ultrastructural features typical of CCD were present on muscle biopsy. Although there are variations in clinical expression, a relativel... | [
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0... |
10,006,464 | Degeneration of the central nervous system associated with celiac disease. | [
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10,006,465 | The following report describes a 57-year-old man with celiac disease who developed a progressive and fatal neurologic disorder despite intensive medical and nutritional care. The clinical and pathological CNS findings in this patient are compared with those of 9 previously reported patients with well documented celiac ... | [
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10,006,466 | Dopamine-beta-hydroxylase (DBH) in idiopathic torsion dystonia (ITD). | [
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0.02189163863658905,
0.02... |
10,006,467 | Dopamine-beta-hydroxylase (DBH) has been reported to be elevated in the serum of patients with idiopathic torsion dystonia. We have examined the levels in jewish patients suffering from that disease and found levels comparable to those of age-and sex-matched controls. | [
0.011216127313673496,
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0... |
10,006,468 | Pathology of peripheral nerves in metachromatic leucodystrophy. A comparative study of ten cases. | [
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0.025754... |
10,006,469 | Results of qualitative and quantitative studies on 1 to 13 peripheral nerves from 10 cases (6 late infantile, 2 juvenile and 2 adult cases) of metachromatic leucodystrophy (MLD) are reported. Peripheral nerve biopsies are still useful despite the arylsulphatase A assays on leucocytes and cultured fibroblasts, since the... | [
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0.07123974710702896,
-0.0257840845733881,
0.0210936... |
10,006,470 | Oculopharyngeal muscular dystrophy. An autopsied case from the French-Canadian kindred. | [
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0.020314857363700867,
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0.0068... |
10,006,471 | We report the complete autopsy findings of a 60-year-old, 12th generation member of the French-Canadian family originally described with oculopharyngeal muscular dystrophy. This report represents the second complete autopsy described in this disease. We show that oculopharyngeal muscular dystrophy is a systemic myopath... | [
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0.01... |
10,006,472 | Conduction velocity in nerve fibres with axonal atrophy due to chronic beta, beta'-iminodiproprionitrile (IDPN). | [
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0.1148... |
10,006,473 | Serial measurements of maximal motor nerve conduction velocity and muscle action potential amplitude were made on 2 groups of rats for up to 16 months. Group A received 0.05% IDPN in drinking water. Group B received a single injection of 1 g/kg i.p. In the chronically intoxicated animals conduction velocity progressive... | [
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10,006,474 | Axon number and size distribution in the developing feline inferior alveolar nerve. | [
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10,006,475 | The number and size distribution of axons in the developing feline inferior alveolar nerve (IAN) were examined by electron microscopy. Seven cat fetuses and thirty kittens and cats aged from 25 days post conception (dpc) to 11 years were used. The total number of IAN axons increased from 4,400 to 16-17,000 between 25 a... | [
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0.0773... |
10,006,476 | Adenylate cyclase in Duchenne fibroblasts. | [
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0.04770853370428085,
0.1... |
10,006,477 | Virus-induced demyelination in herpes simplex virus-infected mice. | [
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0.06626904755830765,
0.0264539... |
10,006,478 | Herpes simplex virus (HSV) infection of the mouse trigeminal ganglia and the brain stem is associated with demyelination of axons in the central part of the trigeminal root and inflammatory cell infiltration and perivascular demyelination in the brain stem. Cyclophosphamide (CPA) treatment prior to or soon after HSV in... | [
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0.05318424105644226,
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0.028... |
10,006,479 | Olivopontocerebellar atrophy. A review of 117 cases. | [
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0... |
10,006,480 | Fifty-four cases of familial OPCA (FOPCA) and sixty-three cases of sporadic OPCA (SOPCA) have been gathered from the literature. The data concerning age at onset, duration of the disease, frequency of symptoms and the various localizations of lesions have been evaluated. In comparison with SOPCA, the disease begins ear... | [
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10,006,481 | Diabetic proximal neuropathy. Clinical and electromyographic studies. | [
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10,006,482 | Clinical and electromyographic findings in 27 diabetics with proximal lower extremity weakness were analyzed. Two groups could be distinguished: patients in whom electromyographic findings were restricted to the clinically involved parts of the lower extremity (group A) and those in whom an associated distal symmetric,... | [
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10,006,483 | Glial fibrillary changes induced by kainic acid in organotypic culture of the rat cerebellum. | [
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0.029479... |
10,006,484 | Comparison of extracellular space in the mature and aging rat brain using a new technique. | [
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0.0536... |
10,006,485 | A new technique for measuring extracellular space in the rat brain has been developed. It involves opening the blood-brain barrier with a bolus of hyperosmotic sucrose followed by a high-pressure perfusion of the cerebral vasculature with an isotonic solution containing an impermeant radioactive tracer, [3H]sucrose. Af... | [
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0.051870062947273254,
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0.11117... |
10,006,486 | Neuropathology, pathogenesis, and neuropsychiatric sequelae of Reye syndrome. | [
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0.12... |
10,006,487 | A clinico-pathologic correlation can be established for those survivors of Reye syndrome in the higher clinical stages who have sustained irreversible and often major neuropsychiatric deficits. The neuropathologic substrate for the clinical manifestations of mental retardation, recurrent seizures, movement disorders, s... | [
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10,006,488 | Electrophysiological findings including single fibre EMG in a family with mitochondrial myopathy. | [
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0.06209947168827057,
0.0142711... |
10,006,489 | Nerve conduction studies, conventional and quantitative concentric needle EMG and single fibre ENG were performed on 5 clinically affected and 7 clinically asymptomatic members of a family with a mitochondrial myopathy manifesting as a facioscapulohumeral syndrome. Abnormalities of nerve conduction present in 3 clinica... | [
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0.0337... |
10,006,490 | Maintenance of dorsal horn somatotopic organization and increased high-threshold response after single-root or spared-root deafferentiation in cats. | [
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0.07030032... |
10,006,491 | Behavioral effect of local cooling in temporal lobe of monkeys. | [
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0.048326... |
10,006,492 | Response characteristics of cochlear nucleus neurons to 500-Hz tones and noise: findings relating to frequency-following potentials. | [
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10,006,493 | Luminance coding of briefly presented stimuli in area 17 of the rhesus monkey. | [
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0.06337... |
10,006,494 | Repetitive firing in trigeminal mesencephalic tract neurons and trigeminal motoneurons. | [
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0.011640721000730991,
0.044... |
10,006,495 | Properties of Golgi-Mazzoni afferents in cat knee joint capsule, as revealed by mechanical studies of isolated joint capsule. | [
-0.012337644584476948,
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0.129194... |
10,006,496 | Properties of Ruffini afferents revealed by stress analysis of isolated sections of cat knee capsule. | [
0.04204515740275383,
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0.048376694321632385,
0.09426... |
10,006,497 | Motor organization of Tritonia swimming. I. Quantitative analysis of swim behavior and flexion neuron firing patterns. | [
0.019594185054302216,
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0.09... |
10,006,498 | Motor organization of Tritonia swimming. II. Synaptic drive to flexion neurons from premotor interneurons. | [
0.01642785780131817,
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0.10837624222040176,
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0.07966... |
10,006,499 | Motor organization of Tritonia swimming. III. Contribution of intrinsic membrane properties to flexion neuron burst formation. | [
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0.09838072210550308,
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0.0867... |
10,006,500 | Clinical and pathological study of meningiomas of the first two decades of life. | [
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0.020912790670990944,
-0.12826335430145264,
0.02395634539425373,
-0.022845368832349777,
0.0578... |
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